methadone has been researched along with Heart Diseases in 8 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There are few studies that describe cardiac adverse events in patients prescribed methadone for pain management." | 7.80 | Methadone for pain and the risk of adverse cardiac outcomes. ( Delate, T; Kurz, D; Price, LC; Shanahan, R; Wobeter, B, 2014) |
| "There are few studies that describe cardiac adverse events in patients prescribed methadone for pain management." | 3.80 | Methadone for pain and the risk of adverse cardiac outcomes. ( Delate, T; Kurz, D; Price, LC; Shanahan, R; Wobeter, B, 2014) |
| "Abstract Methadone maintenance therapy is an established treatment for heroin dependence." | 3.79 | Functional genetic polymorphisms in CYP2C19 gene in relation to cardiac side effects and treatment dose in a methadone maintenance cohort. ( Chang, YS; Chen, AC; Chen, CH; Ho, IK; Hsiao, CF; Huang, CL; Kuo, HW; Lin, KM; Lin, L; Liu, ML; Liu, SC; Liu, SW; Liu, YL; Su, LW; Tan, HK; Tsou, HH; Wang, SC; Wu, CS; Wu, HY; Yang, YH, 2013) |
| "Methadone is a synthetic opioid, a pure agonist of the μ receptor." | 1.62 | Forensic pathological study of methadone-related deaths in the Genoa (Italy) district: A six-year study. ( Barranco, R; Bedocchi, D; Bonsignore, A; Drommi, M; Errico, S; Ventura, F, 2021) |
| "Parenteral substance abuse is widespread." | 1.27 | Primary care of parenteral substance abusers. ( Williams, A, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Errico, S | 1 |
| Bedocchi, D | 1 |
| Drommi, M | 1 |
| Barranco, R | 1 |
| Bonsignore, A | 1 |
| Ventura, F | 1 |
| Pilgrim, JL | 1 |
| McDonough, M | 1 |
| Drummer, OH | 1 |
| Wang, SC | 1 |
| Ho, IK | 1 |
| Tsou, HH | 1 |
| Liu, SW | 1 |
| Hsiao, CF | 1 |
| Chen, CH | 1 |
| Tan, HK | 1 |
| Lin, L | 1 |
| Wu, CS | 1 |
| Su, LW | 1 |
| Huang, CL | 1 |
| Yang, YH | 1 |
| Liu, ML | 1 |
| Lin, KM | 1 |
| Liu, SC | 1 |
| Wu, HY | 1 |
| Kuo, HW | 1 |
| Chen, AC | 1 |
| Chang, YS | 1 |
| Liu, YL | 1 |
| Price, LC | 1 |
| Wobeter, B | 1 |
| Delate, T | 1 |
| Kurz, D | 1 |
| Shanahan, R | 1 |
| Perrin-Terrin, A | 1 |
| Pathak, A | 1 |
| Lapeyre-Mestre, M | 1 |
| Besson, J | 2 |
| Eap, C | 1 |
| Rougemont-Buecking, A | 1 |
| Simon, O | 2 |
| Nikolov, C | 1 |
| Bonsack, C | 1 |
| Gothuey, I | 1 |
| Eap, CB | 1 |
| Khazaal, Y | 1 |
| Montagrin, Y | 1 |
| Rihs-Middel, M | 1 |
| Tissot, H | 1 |
| Tomei, A | 1 |
| Zumwald, C | 1 |
| Zullino, D | 1 |
| Williams, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery: A Randomized, Double-Blinded Controlled Trial[NCT02747875] | 26 participants (Actual) | Interventional | 2016-09-30 | Terminated (stopped due to Drug Shortage) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The distribution of the total opioid dose in the first 24 hours will be evaluated by randomization group (methadone vs. fentanyl) and differences between groups will be tested. It is hypothesized that compared to fentanyl, methadone administered intraoperative will result in a significantly lower total opioid dose (morphine or oxycodone) during the first 24 hour postoperative period. Assuming no difference between the two treatment strategies in the population, a total sample size of 52 in each group will provide 80% power to detect an effect size of 0.1. Significance will be measured as a 30% reduction in postoperative pain requirement. (NCT02747875)
Timeframe: 24 hours
| Intervention | mg postop morphine equivelant 24hr (Mean) |
|---|---|
| Control - Fentanyl | 0.55 |
| Treatment - Methadone | 0.48 |
Opioid-related adverse events will be monitored closely and a secondary analysis will compare the incidence of side effects between the two groups during the first 24-hour postoperative period. The Pearson's contingency chi-square test will be used to evaluate any differences between the randomization groups in opioid-related adverse events during the first 24-hour postoperative period. (NCT02747875)
Timeframe: 24 hours
| Intervention | events (Mean) | |||
|---|---|---|---|---|
| Ondansetron Doses | Emesis Episodes | Hypoventilation Episodes | Arrhythmias | |
| Control - Fentanyl | 3.81 | 2.72 | 0 | 0 |
| Treatment - Methadone | 3.43 | 2.08 | 0 | 0 |
1 review available for methadone and Heart Diseases
| Article | Year |
|---|---|
[Addiction].
Topics: Gambling; Heart Diseases; Humans; Internet; Marijuana Abuse; Methadone; Substance-Related Disorders | 2008 |
1 trial available for methadone and Heart Diseases
| Article | Year |
|---|---|
QT interval prolongation: prevalence, risk factors and pharmacovigilance data among methadone-treated patients in France.
Topics: Adult; Death, Sudden; Death, Sudden, Cardiac; Female; France; Heart Diseases; Humans; Long QT Syndro | 2011 |
6 other studies available for methadone and Heart Diseases
| Article | Year |
|---|---|
Forensic pathological study of methadone-related deaths in the Genoa (Italy) district: A six-year study.
Topics: Adult; Analgesics, Opioid; Blood Alcohol Content; Child, Preschool; Female; Forensic Pathology; Hear | 2021 |
A review of methadone deaths between 2001 and 2005 in Victoria, Australia.
Topics: Adolescent; Adult; Australia; Cause of Death; Chronic Pain; Dose-Response Relationship, Drug; Female | 2013 |
Functional genetic polymorphisms in CYP2C19 gene in relation to cardiac side effects and treatment dose in a methadone maintenance cohort.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cohort Studies; Cytochrome P-450 CYP2C19; Dose-Response Relati | 2013 |
Methadone for pain and the risk of adverse cardiac outcomes.
Topics: Age Factors; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Heart Diseases; Humans; M | 2014 |
[Addictions].
Topics: Cannabis; Eye Movements; Gambling; Heart Diseases; Methadone; Narcotics; Physician-Patient Relations | 2006 |
Primary care of parenteral substance abusers.
Topics: Acquired Immunodeficiency Syndrome; Administration, Intranasal; Antibodies, Viral; Body Weight; Coca | 1986 |