Page last updated: 2024-10-30

methadone and Headache

methadone has been researched along with Headache in 12 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"A refractory chronic migraine (RCM) accompanied by medication-overuse headache (MOH) is an extremely disabling disease."5.62Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study. ( Benemei, S; Bettiol, A; Chiarugi, A; De Cesaris, F; Galli, V; Geppetti, P; Lombardi, N; Lupi, C; Mannaioni, G; Occupati, B; Pracucci, C, 2021)
"Thirty-three consecutive patients with primary chronic daily headache were managed according to a treatment pathway which involved sequential administration of divalproex sodium, amitriptyline, amitriptyline plus phenelzine, or methadone."5.09Management of chronic daily headache utilizing a uniform treatment pathway. ( Rothrock, JF, 1999)
" She developed post-dural puncture headache (PDPH) on the third postpartum day which was managed by palliative measures: bed rest (patient's position of choice), increased hydration (water: 3 litres po per day), lysine acetyl salicylate (5."3.70Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour. ( Agustí, M; Carrero, EJ; Fábregas, N; Fernández, C; Valldeoriola, F, 1998)
" The most frequent treatment-emergent non-OWS adverse events were headache, nausea, constipation, and neck pain."2.82Switching Opioid-Dependent Patients From Methadone to Morphine: Safety, Tolerability, and Methadone Pharmacokinetics. ( Cape, G; Devane, J; Friedhoff, L; Glue, P; Gray, A; Harland, S; Howes, J; Hung, CT; Hung, N; Lam, F; Lockhart, M; Tunnicliff, D; Weis, H, 2016)
"This trial was aimed to estimate the pharmacokinetic interaction between voriconazole and methadone at steady state in male patients on methadone therapy and to characterize the safety and tolerability profile during the coadministration."2.73Pharmacokinetic interaction between voriconazole and methadone at steady state in patients on methadone therapy. ( Foster, G; Labadie, R; Liu, P; Sharma, A; Somoza, E, 2007)
" Plasma concentrations and pharmacokinetic parameters of R- and S-methadone isomers were determined on days -1, 7, and 14 and of TMC125 on days 7 and 14."2.73Pharmacokinetic and pharmacodynamic study of the concomitant administration of methadone and TMC125 in HIV-negative volunteers. ( De Smedt, G; Hoetelmans, RM; Kakuda, TN; Peeters, M; Schöller-Gyüre, M; Stevens, T; van den Brink, W; Vanaken, H; Vandermeulen, K; Woodfall, B, 2008)
"A refractory chronic migraine (RCM) accompanied by medication-overuse headache (MOH) is an extremely disabling disease."1.62Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study. ( Benemei, S; Bettiol, A; Chiarugi, A; De Cesaris, F; Galli, V; Geppetti, P; Lombardi, N; Lupi, C; Mannaioni, G; Occupati, B; Pracucci, C, 2021)
"Long-term drug abuse detrimentally affects the stomatognathic system, as expressed in a high prevalence of oral motor behavior and signs and symptoms of TMD."1.31Oral motor parafunctions among heavy drug addicts and their effects on signs and symptoms of temporomandibular disorders. ( Gavish, A; Gazit, E; Halachmi, M; Volfin, G; Winocur, E, 2001)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's2 (16.67)18.2507
2000's5 (41.67)29.6817
2010's1 (8.33)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Benemei, S1
Lupi, C1
De Cesaris, F1
Lombardi, N1
Bettiol, A1
Chiarugi, A1
Geppetti, P1
Galli, V1
Pracucci, C1
Occupati, B1
Mannaioni, G1
Glue, P1
Cape, G1
Tunnicliff, D1
Lockhart, M1
Lam, F1
Gray, A1
Hung, N1
Hung, CT1
Harland, S1
Devane, J1
Howes, J1
Weis, H1
Friedhoff, L1
Farahmand, N1
Drennan, D1
Junkins, S1
Ashwath, ML1
Ajjan, M1
Culclasure, T1
Liu, P1
Foster, G1
Labadie, R1
Somoza, E1
Sharma, A1
Schöller-Gyüre, M1
van den Brink, W1
Kakuda, TN1
Woodfall, B1
De Smedt, G1
Vanaken, H1
Stevens, T1
Peeters, M1
Vandermeulen, K1
Hoetelmans, RM1
Carrero, EJ1
Agustí, M1
Fábregas, N1
Valldeoriola, F1
Fernández, C1
Rothrock, JF1
Winocur, E1
Gavish, A1
Volfin, G1
Halachmi, M1
Gazit, E1
DePierro, K1
Resnick, RB1
Volavka, J1
Freedman, AM1
Thomas, M1
Tamarkin, NR1
Goodwin, FK1
Axelrod, J1

Trials

4 trials available for methadone and Headache

ArticleYear
Switching Opioid-Dependent Patients From Methadone to Morphine: Safety, Tolerability, and Methadone Pharmacokinetics.
    Journal of clinical pharmacology, 2016, Volume: 56, Issue:8

    Topics: Adult; Analgesics, Opioid; Double-Blind Method; Drug Substitution; Female; Headache; Humans; Ibogain

2016
Pharmacokinetic interaction between voriconazole and methadone at steady state in patients on methadone therapy.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:1

    Topics: Adult; Antifungal Agents; Area Under Curve; Back Pain; Dose-Response Relationship, Drug; Double-Blin

2007
Pharmacokinetic and pharmacodynamic study of the concomitant administration of methadone and TMC125 in HIV-negative volunteers.
    Journal of clinical pharmacology, 2008, Volume: 48, Issue:3

    Topics: Adult; Area Under Curve; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combinat

2008
Management of chronic daily headache utilizing a uniform treatment pathway.
    Headache, 1999, Volume: 39, Issue:9

    Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Dru

1999

Other Studies

8 other studies available for methadone and Headache

ArticleYear
Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021, Volume: 42, Issue:3

    Topics: Female; Headache; Headache Disorders, Secondary; Humans; Methadone; Middle Aged; Migraine Disorders;

2021
Patient education and self-advocacy: queries and responses on pain management.
    Journal of pain & palliative care pharmacotherapy, 2008, Volume: 22, Issue:4

    Topics: Caffeine; Chronic Pain; Headache; Humans; Methadone; Pain Management; Sleep Apnea Syndromes

2008
Methadone-induced bradycardia.
    The Journal of emergency medicine, 2005, Volume: 29, Issue:1

    Topics: Administration, Oral; Adult; Bradycardia; Diagnosis, Differential; Electrocardiography; Headache; Hu

2005
Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:9

    Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, No

1998
Oral motor parafunctions among heavy drug addicts and their effects on signs and symptoms of temporomandibular disorders.
    Journal of orofacial pain, 2001,Winter, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Bruxism; Case-Control Studies; Chi-Square Distribution; Cocaine-Related Disorders

2001
Preserving the character of Vermont for the good of the citizenry.
    Journal of substance abuse treatment, 1985, Volume: 2, Issue:1

    Topics: Acetaminophen; Adult; Dextropropoxyphene; Drug Combinations; Headache; Humans; Legislation, Drug; Ma

1985
Studies of EN-1639A (naltrexone): a new narcotic antagonist.
    The American journal of psychiatry, 1974, Volume: 131, Issue:6

    Topics: Administration, Oral; Adult; Cyclazocine; Cyclopropanes; Dose-Response Relationship, Drug; Headache;

1974
Rapid elevation of biogenic amine metabolites in human CSF following probenecid.
    Life sciences. Pt. 1: Physiology and pharmacology, 1970, Dec-15, Volume: 9, Issue:24

    Topics: Administration, Oral; Affective Symptoms; Dihydroxyphenylalanine; Female; Headache; Humans; Hydroxyi

1970