methadone has been researched along with Headache in 12 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A refractory chronic migraine (RCM) accompanied by medication-overuse headache (MOH) is an extremely disabling disease." | 5.62 | Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study. ( Benemei, S; Bettiol, A; Chiarugi, A; De Cesaris, F; Galli, V; Geppetti, P; Lombardi, N; Lupi, C; Mannaioni, G; Occupati, B; Pracucci, C, 2021) |
| "Thirty-three consecutive patients with primary chronic daily headache were managed according to a treatment pathway which involved sequential administration of divalproex sodium, amitriptyline, amitriptyline plus phenelzine, or methadone." | 5.09 | Management of chronic daily headache utilizing a uniform treatment pathway. ( Rothrock, JF, 1999) |
| " She developed post-dural puncture headache (PDPH) on the third postpartum day which was managed by palliative measures: bed rest (patient's position of choice), increased hydration (water: 3 litres po per day), lysine acetyl salicylate (5." | 3.70 | Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour. ( Agustí, M; Carrero, EJ; Fábregas, N; Fernández, C; Valldeoriola, F, 1998) |
| " The most frequent treatment-emergent non-OWS adverse events were headache, nausea, constipation, and neck pain." | 2.82 | Switching Opioid-Dependent Patients From Methadone to Morphine: Safety, Tolerability, and Methadone Pharmacokinetics. ( Cape, G; Devane, J; Friedhoff, L; Glue, P; Gray, A; Harland, S; Howes, J; Hung, CT; Hung, N; Lam, F; Lockhart, M; Tunnicliff, D; Weis, H, 2016) |
| "This trial was aimed to estimate the pharmacokinetic interaction between voriconazole and methadone at steady state in male patients on methadone therapy and to characterize the safety and tolerability profile during the coadministration." | 2.73 | Pharmacokinetic interaction between voriconazole and methadone at steady state in patients on methadone therapy. ( Foster, G; Labadie, R; Liu, P; Sharma, A; Somoza, E, 2007) |
| " Plasma concentrations and pharmacokinetic parameters of R- and S-methadone isomers were determined on days -1, 7, and 14 and of TMC125 on days 7 and 14." | 2.73 | Pharmacokinetic and pharmacodynamic study of the concomitant administration of methadone and TMC125 in HIV-negative volunteers. ( De Smedt, G; Hoetelmans, RM; Kakuda, TN; Peeters, M; Schöller-Gyüre, M; Stevens, T; van den Brink, W; Vanaken, H; Vandermeulen, K; Woodfall, B, 2008) |
| "A refractory chronic migraine (RCM) accompanied by medication-overuse headache (MOH) is an extremely disabling disease." | 1.62 | Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study. ( Benemei, S; Bettiol, A; Chiarugi, A; De Cesaris, F; Galli, V; Geppetti, P; Lombardi, N; Lupi, C; Mannaioni, G; Occupati, B; Pracucci, C, 2021) |
| "Long-term drug abuse detrimentally affects the stomatognathic system, as expressed in a high prevalence of oral motor behavior and signs and symptoms of TMD." | 1.31 | Oral motor parafunctions among heavy drug addicts and their effects on signs and symptoms of temporomandibular disorders. ( Gavish, A; Gazit, E; Halachmi, M; Volfin, G; Winocur, E, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Benemei, S | 1 |
| Lupi, C | 1 |
| De Cesaris, F | 1 |
| Lombardi, N | 1 |
| Bettiol, A | 1 |
| Chiarugi, A | 1 |
| Geppetti, P | 1 |
| Galli, V | 1 |
| Pracucci, C | 1 |
| Occupati, B | 1 |
| Mannaioni, G | 1 |
| Glue, P | 1 |
| Cape, G | 1 |
| Tunnicliff, D | 1 |
| Lockhart, M | 1 |
| Lam, F | 1 |
| Gray, A | 1 |
| Hung, N | 1 |
| Hung, CT | 1 |
| Harland, S | 1 |
| Devane, J | 1 |
| Howes, J | 1 |
| Weis, H | 1 |
| Friedhoff, L | 1 |
| Farahmand, N | 1 |
| Drennan, D | 1 |
| Junkins, S | 1 |
| Ashwath, ML | 1 |
| Ajjan, M | 1 |
| Culclasure, T | 1 |
| Liu, P | 1 |
| Foster, G | 1 |
| Labadie, R | 1 |
| Somoza, E | 1 |
| Sharma, A | 1 |
| Schöller-Gyüre, M | 1 |
| van den Brink, W | 1 |
| Kakuda, TN | 1 |
| Woodfall, B | 1 |
| De Smedt, G | 1 |
| Vanaken, H | 1 |
| Stevens, T | 1 |
| Peeters, M | 1 |
| Vandermeulen, K | 1 |
| Hoetelmans, RM | 1 |
| Carrero, EJ | 1 |
| Agustí, M | 1 |
| Fábregas, N | 1 |
| Valldeoriola, F | 1 |
| Fernández, C | 1 |
| Rothrock, JF | 1 |
| Winocur, E | 1 |
| Gavish, A | 1 |
| Volfin, G | 1 |
| Halachmi, M | 1 |
| Gazit, E | 1 |
| DePierro, K | 1 |
| Resnick, RB | 1 |
| Volavka, J | 1 |
| Freedman, AM | 1 |
| Thomas, M | 1 |
| Tamarkin, NR | 1 |
| Goodwin, FK | 1 |
| Axelrod, J | 1 |
4 trials available for methadone and Headache
| Article | Year |
|---|---|
Switching Opioid-Dependent Patients From Methadone to Morphine: Safety, Tolerability, and Methadone Pharmacokinetics.
Topics: Adult; Analgesics, Opioid; Double-Blind Method; Drug Substitution; Female; Headache; Humans; Ibogain | 2016 |
Pharmacokinetic interaction between voriconazole and methadone at steady state in patients on methadone therapy.
Topics: Adult; Antifungal Agents; Area Under Curve; Back Pain; Dose-Response Relationship, Drug; Double-Blin | 2007 |
Pharmacokinetic and pharmacodynamic study of the concomitant administration of methadone and TMC125 in HIV-negative volunteers.
Topics: Adult; Area Under Curve; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combinat | 2008 |
Management of chronic daily headache utilizing a uniform treatment pathway.
Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Dru | 1999 |
8 other studies available for methadone and Headache
| Article | Year |
|---|---|
Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study.
Topics: Female; Headache; Headache Disorders, Secondary; Humans; Methadone; Middle Aged; Migraine Disorders; | 2021 |
Patient education and self-advocacy: queries and responses on pain management.
Topics: Caffeine; Chronic Pain; Headache; Humans; Methadone; Pain Management; Sleep Apnea Syndromes | 2008 |
Methadone-induced bradycardia.
Topics: Administration, Oral; Adult; Bradycardia; Diagnosis, Differential; Electrocardiography; Headache; Hu | 2005 |
Unilateral trigeminal and facial nerve palsies associated with epidural analgesia in labour.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, No | 1998 |
Oral motor parafunctions among heavy drug addicts and their effects on signs and symptoms of temporomandibular disorders.
Topics: Adolescent; Adult; Bruxism; Case-Control Studies; Chi-Square Distribution; Cocaine-Related Disorders | 2001 |
Preserving the character of Vermont for the good of the citizenry.
Topics: Acetaminophen; Adult; Dextropropoxyphene; Drug Combinations; Headache; Humans; Legislation, Drug; Ma | 1985 |
Studies of EN-1639A (naltrexone): a new narcotic antagonist.
Topics: Administration, Oral; Adult; Cyclazocine; Cyclopropanes; Dose-Response Relationship, Drug; Headache; | 1974 |
Rapid elevation of biogenic amine metabolites in human CSF following probenecid.
Topics: Administration, Oral; Affective Symptoms; Dihydroxyphenylalanine; Female; Headache; Humans; Hydroxyi | 1970 |