methadone has been researched along with HbS Disease in 8 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " There is little information on methadone use for SCD pain." | 5.22 | Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease. ( Deych, E; Frei-Jones, M; Horst, J; Kharasch, ED; Shannon, W, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nnoli, A | 1 |
| Seligman, NS | 1 |
| Dysart, K | 1 |
| Baxter, JK | 1 |
| Ballas, SK | 1 |
| LeBlanc, Z | 1 |
| Vance, C | 1 |
| Payne, J | 1 |
| Zhang, J | 1 |
| Hilliard, L | 1 |
| Lebensburger, JD | 1 |
| Howard, TH | 1 |
| Upadhya, B | 1 |
| Ntim, W | 1 |
| Brandon Stacey, R | 1 |
| Henderson, R | 1 |
| Leedy, D | 1 |
| O'Brien, FX | 1 |
| Knovich, MA | 1 |
| Horst, J | 2 |
| Frei-Jones, M | 1 |
| Deych, E | 1 |
| Shannon, W | 1 |
| Kharasch, ED | 2 |
| Wu, H | 1 |
| Wang, D | 1 |
| Ruan, X | 1 |
| Shaiova, L | 1 |
| Wallenstein, D | 1 |
| Porter, BO | 1 |
| Coyne, PJ | 1 |
| Smith, WR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methadone in Pediatric and Adult Sickle Cell Patients[NCT00761085] | 47 participants (Actual) | Interventional | 2008-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Pain relief score using the 10CM VAS, which has a pain scale of 0-10, with 0=no pain and 10=worst pain experienced (NCT00761085)
Timeframe: 72 hr
| Intervention | units on a scale (Mean) |
|---|---|
| Methadone-Children | 8 |
| Morphine-Children | 4 |
| Methadone-Adults | 5 |
| Morphine-Adults | 5 |
R-Methadone AUC (NCT00761085)
Timeframe: 96 hr
| Intervention | (hr*ng/ml) (Mean) |
|---|---|
| Methadone-Children | 523 |
| Morphine-Children | 0 |
| Methadone-Adults | 637 |
| Morphine-Adults | 0 |
1 trial available for methadone and HbS Disease
| Article | Year |
|---|---|
Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.
Topics: Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Child; Female; Humans; Male; Methadone; Pain | 2016 |
7 other studies available for methadone and HbS Disease
| Article | Year |
|---|---|
Opioid Utilization by Pregnant Women with Sickle Cell Disease and the Risk of Neonatal Abstinence Syndrome.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Case-Control Studies; Female; Humans; Incidence; Met | 2018 |
Management of severe chronic pain with methadone in pediatric patients with sickle cell disease.
Topics: Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Child; Chronic Pain; Cohort Studies; Female; Hu | 2018 |
Prolongation of QTc intervals and risk of death among patients with sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Death, Sudden, Cardiac; Echocardiography; Electrocardiography; Female; F | 2013 |
Comment on: Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Child; Humans; Methadone | 2017 |
Reply to comment on: Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Child; Humans; Methadone | 2017 |
Outpatient management of sickle cell pain with chronic opioid pharmacotherapy.
Topics: Adult; Ambulatory Care; Analgesics, Opioid; Anemia, Sickle Cell; Female; Fentanyl; Humans; Male; Met | 2004 |
Methadone-related Torsades de Pointes in a sickle cell patient treated for chronic pain.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Male; Methadone; Pain; Torsades de Pointes | 2005 |