methadone and HIV
methadone has been researched along with HIV in 16 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Whether HIV-positive injecting drug users (IDUs) are at higher risk of developing drug resistance mutations (DRMs) after methadone maintenance therapy (MMT) than any other HIV-positive population is unclear." | 7.96 | No Increase in HIV Drug Resistance Mutations among Injecting Drug Users on Methadone Maintenance Therapy: A Prospective Cohort Study. ( Abdullah, AS; Hu, X; Huang, C; Huang, J; Jiang, J; Lao, F; Liang, B; Liang, H; Liu, H; Luo, C; Ning, C; Yang, Q; Yang, Y; Ye, L; Zang, N; Zhang, Y, 2020) |
| "Ongoing drug use during methadone maintenance treatment (MMT) negatively affects outcomes of HIV/AIDS care and treatment for drug users." | 7.78 | Multilevel predictors of concurrent opioid use during methadone maintenance treatment among drug users with HIV/AIDS. ( Duong, AT; Houston, S; Jacobs, P; Mills, S; Nguyen, LT; Ohinmaa, A; Tran, BX, 2012) |
| " A bibliographic review was conducted to evaluate the impact of adherence to heroin dependence treatment on human immunodeficiency virus (HIV) transmission and to identify interventions proven to be effective in improving adherence." | 7.72 | Adherence to heroin dependence therapies and human immunodeficiency virus/acquired immunodeficiency syndrome infection rates among drug abusers. ( De Castro, S; Sabaté, E, 2003) |
| "Investigators at the University of Pennsylvania School of Medicine have found that HIV replication in vitro is promoted by the opiate methadone." | 7.71 | Methadone may promote HIV replication: study. ( Douglas, SD, 2001) |
| "Treatment with isoniazid was beneficial in HIV-infected, tuberculin-positive IDUs." | 5.32 | Effectiveness of isoniazid treatment for latent tuberculosis infection among human immunodeficiency virus (HIV)-infected and HIV-uninfected injection drug users in methadone programs. ( Amofa, J; Driver, CR; Fujiwara, PI; Gourevitch, MN; Highley, E; Kaye, K; Munsiff, SS; Rubino, MA; Scholten, JN; Seewald, R; Trim, C, 2003) |
| " However, there are no special HCV or HIV (human immunodeficiency virus)-related intervention programs that are tailored for drug users in China; to fill this gap, the purpose of this study was to explore HCV and HIV-related knowledge among drug users in MMT (methadone maintenance treatment) sites of China and to investigate the effectiveness of HCV and HIV-related education for improving the knowledge of IDUs (injection drug users) and their awareness of infection." | 5.30 | DOES IT WORK? -a randomized controlled trial to test the efficacy of HCV and HIV-related education on drug users in MMT, China. ( Du, J; Huang, LP; Li, Z; Li, ZB; Wang, J; Zhan, GL; Zhang, JY; Zhang, L; Zhao, M, 2019) |
| "Methadone clinic-based directly observed antiretroviral therapy (DOT) has been shown to be more efficacious for improving adherence and suppressing human immunodeficiency virus (HIV) load than antiretroviral self-administration." | 5.15 | Lack of sustained improvement in adherence or viral load following a directly observed antiretroviral therapy intervention. ( Arnsten, JH; Berg, KM; Heo, M; Li, X; Litwin, AH, 2011) |
| "Whether HIV-positive injecting drug users (IDUs) are at higher risk of developing drug resistance mutations (DRMs) after methadone maintenance therapy (MMT) than any other HIV-positive population is unclear." | 3.96 | No Increase in HIV Drug Resistance Mutations among Injecting Drug Users on Methadone Maintenance Therapy: A Prospective Cohort Study. ( Abdullah, AS; Hu, X; Huang, C; Huang, J; Jiang, J; Lao, F; Liang, B; Liang, H; Liu, H; Luo, C; Ning, C; Yang, Q; Yang, Y; Ye, L; Zang, N; Zhang, Y, 2020) |
| "Ongoing drug use during methadone maintenance treatment (MMT) negatively affects outcomes of HIV/AIDS care and treatment for drug users." | 3.78 | Multilevel predictors of concurrent opioid use during methadone maintenance treatment among drug users with HIV/AIDS. ( Duong, AT; Houston, S; Jacobs, P; Mills, S; Nguyen, LT; Ohinmaa, A; Tran, BX, 2012) |
| " A bibliographic review was conducted to evaluate the impact of adherence to heroin dependence treatment on human immunodeficiency virus (HIV) transmission and to identify interventions proven to be effective in improving adherence." | 3.72 | Adherence to heroin dependence therapies and human immunodeficiency virus/acquired immunodeficiency syndrome infection rates among drug abusers. ( De Castro, S; Sabaté, E, 2003) |
| "DOT should be considered for substance users attending methadone maintenance clinics who are at high risk of nonadherence." | 2.76 | Directly observed antiretroviral therapy in substance abusers receiving methadone maintenance therapy does not cause increased drug resistance. ( Arnsten, JH; Berg, KM; Brust, JC; Heo, M; Li, X; Litwin, AH, 2011) |
| "Treatment with isoniazid was beneficial in HIV-infected, tuberculin-positive IDUs." | 1.32 | Effectiveness of isoniazid treatment for latent tuberculosis infection among human immunodeficiency virus (HIV)-infected and HIV-uninfected injection drug users in methadone programs. ( Amofa, J; Driver, CR; Fujiwara, PI; Gourevitch, MN; Highley, E; Kaye, K; Munsiff, SS; Rubino, MA; Scholten, JN; Seewald, R; Trim, C, 2003) |
| "Using the 1993 clinical definition of AIDS, we found that the hazard ratio (HR) of progression to AIDS declined for enrollees over time in comparison with the referent group of persons enrolled in 1986-1987." | 1.30 | Temporal trends in the progression of human immunodeficiency virus disease in a cohort of drug users. ( Buono, D; Chang, CJ; Gourevitch, MN; Klein, RS; Schoenbaum, EE; Webber, MP, 1998) |
Research
Studies (16)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Zhang, JY | 1 |
| Li, ZB | 1 |
| Zhang, L | 1 |
| Wang, J | 1 |
| Huang, LP | 1 |
| Zhan, GL | 1 |
| Li, Z | 1 |
| Du, J | 1 |
| Zhao, M | 1 |
| Wu, KH | 1 |
| Juan, SC | 1 |
| Chan, CH | 1 |
| Chou, SY | 1 |
| Chan, HY | 1 |
| Huang, C | 1 |
| Ye, L | 1 |
| Abdullah, AS | 1 |
| Liang, B | 1 |
| Jiang, J | 1 |
| Ning, C | 1 |
| Zang, N | 1 |
| Zhang, Y | 1 |
| Yang, Y | 1 |
| Hu, X | 1 |
| Yang, Q | 1 |
| Luo, C | 1 |
| Lao, F | 1 |
| Liu, H | 1 |
| Liang, H | 1 |
| Huang, J | 1 |
| Culbert, GJ | 1 |
| Waluyo, A | 1 |
| Wang, M | 1 |
| Putri, TA | 1 |
| Bazazi, AR | 1 |
| Altice, FL | 1 |
| Wang, L | 1 |
| Wei, X | 1 |
| Wang, X | 1 |
| Li, J | 1 |
| Li, H | 1 |
| Jia, W | 1 |
| Suntharasamai, P | 1 |
| Martin, M | 1 |
| Vanichseni, S | 1 |
| van Griensven, F | 1 |
| Mock, PA | 1 |
| Pitisuttithum, P | 1 |
| Tappero, JW | 1 |
| Sangkum, U | 1 |
| Kitayaporn, D | 1 |
| Gurwith, M | 1 |
| Choopanya, K | 1 |
| Brust, JC | 1 |
| Litwin, AH | 2 |
| Berg, KM | 2 |
| Li, X | 2 |
| Heo, M | 2 |
| Arnsten, JH | 2 |
| Tran, BX | 1 |
| Ohinmaa, A | 1 |
| Mills, S | 1 |
| Duong, AT | 1 |
| Nguyen, LT | 1 |
| Jacobs, P | 1 |
| Houston, S | 1 |
| De Castro, S | 1 |
| Sabaté, E | 1 |
| Scholten, JN | 1 |
| Driver, CR | 1 |
| Munsiff, SS | 1 |
| Kaye, K | 1 |
| Rubino, MA | 1 |
| Gourevitch, MN | 2 |
| Trim, C | 1 |
| Amofa, J | 1 |
| Seewald, R | 1 |
| Highley, E | 1 |
| Fujiwara, PI | 1 |
| Esteban, J | 1 |
| de la Cruz Pellín, M | 1 |
| Gimeno, C | 1 |
| Barril, J | 1 |
| Mora, E | 1 |
| Giménez, J | 1 |
| Vilanova, E | 1 |
| Raffa, JD | 1 |
| Tossonian, HK | 1 |
| Grebely, J | 1 |
| Petkau, AJ | 1 |
| DeVlaming, S | 1 |
| Conway, B | 1 |
| Webber, MP | 1 |
| Schoenbaum, EE | 1 |
| Buono, D | 1 |
| Chang, CJ | 1 |
| Klein, RS | 1 |
| Douglas, SD | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reducing Hepatitis C Virus (HCV)/Human Immunodeficient Virus (HIV) Risk Behaviors Among Injection Drug Users in China[NCT01647191] | 240 participants (Actual) | Interventional | 2011-07-01 | Completed | |||
| A Phase III Trial to Determine the Efficacy of AIDSVAX B/E Vaccine in Intravenous Drug Users in Bangkok, Thailand[NCT00006327] | Phase 3 | 2,500 participants | Interventional | 1999-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trials
4 trials available for methadone and HIV
| Article | Year |
|---|---|
DOES IT WORK? -a randomized controlled trial to test the efficacy of HCV and HIV-related education on drug users in MMT, China.
Topics: Adult; Awareness; China; Cluster Analysis; Drug Users; Efficiency, Organizational; Female; Health Kn | 2019 |
Factors associated with incarceration and incident human immunodeficiency virus (HIV) infection among injection drug users participating in an HIV vaccine trial in Bangkok, Thailand, 1999-2003.
Topics: Adult; AIDS Vaccines; Amphetamine-Related Disorders; Double-Blind Method; Female; HIV; HIV Infection | 2009 |
Directly observed antiretroviral therapy in substance abusers receiving methadone maintenance therapy does not cause increased drug resistance.
Topics: Adult; Amino Acid Substitution; Analgesics, Opioid; Anti-HIV Agents; Directly Observed Therapy; Drug | 2011 |
Lack of sustained improvement in adherence or viral load following a directly observed antiretroviral therapy intervention.
Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Directly Observed The | 2011 |
Other Studies
12 other studies available for methadone and HIV
| Article | Year |
|---|---|
Factors Affecting Changes of Cluster of Differentiation 4 Cell Counts Among Human Immunodeficiency Virus-positive People Who Inject Heroin and Receive Methadone Maintenance Treatment.
Topics: Cell Count; Cell Differentiation; Heroin; HIV; HIV Infections; Humans; Longitudinal Studies; Methado | 2020 |
No Increase in HIV Drug Resistance Mutations among Injecting Drug Users on Methadone Maintenance Therapy: A Prospective Cohort Study.
Topics: Adult; China; Cohort Studies; Drug Resistance; Drug Users; Female; HIV; HIV Infections; Humans; Main | 2020 |
Adherence to Antiretroviral Therapy Among Incarcerated Persons with HIV: Associations with Methadone and Perceived Safety.
Topics: Adult; Antiretroviral Therapy, Highly Active; Cross-Sectional Studies; HIV; HIV Infections; Humans; | 2019 |
Long-term effects of methadone maintenance treatment with different psychosocial intervention models.
Topics: Adult; China; Counseling; Female; Follow-Up Studies; Hepatitis C; HIV; HIV Infections; Humans; Male; | 2014 |
Multilevel predictors of concurrent opioid use during methadone maintenance treatment among drug users with HIV/AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Analgesics, Opioid; Cohort Studies; Demography; Drug User | 2012 |
Adherence to heroin dependence therapies and human immunodeficiency virus/acquired immunodeficiency syndrome infection rates among drug abusers.
Topics: Acquired Immunodeficiency Syndrome; Heroin; Heroin Dependence; HIV; HIV Seroprevalence; Humans; Meth | 2003 |
Effectiveness of isoniazid treatment for latent tuberculosis infection among human immunodeficiency virus (HIV)-infected and HIV-uninfected injection drug users in methadone programs.
Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Antitubercular Agents; Female; HIV; HIV Infectio | 2003 |
Detection of clinical interactions between methadone and anti-retroviral compounds using an enantioselective capillary electrophoresis for methadone analysis.
Topics: Adult; Anti-Retroviral Agents; Cocaine; Drug Interactions; Electrophoresis, Capillary; Heroin; HIV; | 2004 |
Intermediate highly active antiretroviral therapy adherence thresholds and empirical models for the development of drug resistance mutations.
Topics: Adult; Antiretroviral Therapy, Highly Active; Canada; CD4 Lymphocyte Count; Drug Resistance, Viral; | 2008 |
Southwest China opens methadone clinics in border areas to prevent spread of HIV.
Topics: Ambulatory Care Facilities; China; HIV; HIV Infections; Humans; Methadone; Rural Population; Substan | 2008 |
Temporal trends in the progression of human immunodeficiency virus disease in a cohort of drug users.
Topics: Acquired Immunodeficiency Syndrome; Adult; Cohort Studies; Disease Progression; Female; Health Servi | 1998 |
Methadone may promote HIV replication: study.
Topics: HIV; HIV Long Terminal Repeat; Humans; Methadone; Receptors, CCR5; Virus Replication | 2001 |