Page last updated: 2024-10-30

methadone and HIV

methadone has been researched along with HIV in 16 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.

Research Excerpts

ExcerptRelevanceReference
"Whether HIV-positive injecting drug users (IDUs) are at higher risk of developing drug resistance mutations (DRMs) after methadone maintenance therapy (MMT) than any other HIV-positive population is unclear."7.96No Increase in HIV Drug Resistance Mutations among Injecting Drug Users on Methadone Maintenance Therapy: A Prospective Cohort Study. ( Abdullah, AS; Hu, X; Huang, C; Huang, J; Jiang, J; Lao, F; Liang, B; Liang, H; Liu, H; Luo, C; Ning, C; Yang, Q; Yang, Y; Ye, L; Zang, N; Zhang, Y, 2020)
"Ongoing drug use during methadone maintenance treatment (MMT) negatively affects outcomes of HIV/AIDS care and treatment for drug users."7.78Multilevel predictors of concurrent opioid use during methadone maintenance treatment among drug users with HIV/AIDS. ( Duong, AT; Houston, S; Jacobs, P; Mills, S; Nguyen, LT; Ohinmaa, A; Tran, BX, 2012)
" A bibliographic review was conducted to evaluate the impact of adherence to heroin dependence treatment on human immunodeficiency virus (HIV) transmission and to identify interventions proven to be effective in improving adherence."7.72Adherence to heroin dependence therapies and human immunodeficiency virus/acquired immunodeficiency syndrome infection rates among drug abusers. ( De Castro, S; Sabaté, E, 2003)
"Investigators at the University of Pennsylvania School of Medicine have found that HIV replication in vitro is promoted by the opiate methadone."7.71Methadone may promote HIV replication: study. ( Douglas, SD, 2001)
"Treatment with isoniazid was beneficial in HIV-infected, tuberculin-positive IDUs."5.32Effectiveness of isoniazid treatment for latent tuberculosis infection among human immunodeficiency virus (HIV)-infected and HIV-uninfected injection drug users in methadone programs. ( Amofa, J; Driver, CR; Fujiwara, PI; Gourevitch, MN; Highley, E; Kaye, K; Munsiff, SS; Rubino, MA; Scholten, JN; Seewald, R; Trim, C, 2003)
" However, there are no special HCV or HIV (human immunodeficiency virus)-related intervention programs that are tailored for drug users in China; to fill this gap, the purpose of this study was to explore HCV and HIV-related knowledge among drug users in MMT (methadone maintenance treatment) sites of China and to investigate the effectiveness of HCV and HIV-related education for improving the knowledge of IDUs (injection drug users) and their awareness of infection."5.30DOES IT WORK? -a randomized controlled trial to test the efficacy of HCV and HIV-related education on drug users in MMT, China. ( Du, J; Huang, LP; Li, Z; Li, ZB; Wang, J; Zhan, GL; Zhang, JY; Zhang, L; Zhao, M, 2019)
"Methadone clinic-based directly observed antiretroviral therapy (DOT) has been shown to be more efficacious for improving adherence and suppressing human immunodeficiency virus (HIV) load than antiretroviral self-administration."5.15Lack of sustained improvement in adherence or viral load following a directly observed antiretroviral therapy intervention. ( Arnsten, JH; Berg, KM; Heo, M; Li, X; Litwin, AH, 2011)
"Whether HIV-positive injecting drug users (IDUs) are at higher risk of developing drug resistance mutations (DRMs) after methadone maintenance therapy (MMT) than any other HIV-positive population is unclear."3.96No Increase in HIV Drug Resistance Mutations among Injecting Drug Users on Methadone Maintenance Therapy: A Prospective Cohort Study. ( Abdullah, AS; Hu, X; Huang, C; Huang, J; Jiang, J; Lao, F; Liang, B; Liang, H; Liu, H; Luo, C; Ning, C; Yang, Q; Yang, Y; Ye, L; Zang, N; Zhang, Y, 2020)
"Ongoing drug use during methadone maintenance treatment (MMT) negatively affects outcomes of HIV/AIDS care and treatment for drug users."3.78Multilevel predictors of concurrent opioid use during methadone maintenance treatment among drug users with HIV/AIDS. ( Duong, AT; Houston, S; Jacobs, P; Mills, S; Nguyen, LT; Ohinmaa, A; Tran, BX, 2012)
" A bibliographic review was conducted to evaluate the impact of adherence to heroin dependence treatment on human immunodeficiency virus (HIV) transmission and to identify interventions proven to be effective in improving adherence."3.72Adherence to heroin dependence therapies and human immunodeficiency virus/acquired immunodeficiency syndrome infection rates among drug abusers. ( De Castro, S; Sabaté, E, 2003)
"DOT should be considered for substance users attending methadone maintenance clinics who are at high risk of nonadherence."2.76Directly observed antiretroviral therapy in substance abusers receiving methadone maintenance therapy does not cause increased drug resistance. ( Arnsten, JH; Berg, KM; Brust, JC; Heo, M; Li, X; Litwin, AH, 2011)
"Treatment with isoniazid was beneficial in HIV-infected, tuberculin-positive IDUs."1.32Effectiveness of isoniazid treatment for latent tuberculosis infection among human immunodeficiency virus (HIV)-infected and HIV-uninfected injection drug users in methadone programs. ( Amofa, J; Driver, CR; Fujiwara, PI; Gourevitch, MN; Highley, E; Kaye, K; Munsiff, SS; Rubino, MA; Scholten, JN; Seewald, R; Trim, C, 2003)
"Using the 1993 clinical definition of AIDS, we found that the hazard ratio (HR) of progression to AIDS declined for enrollees over time in comparison with the referent group of persons enrolled in 1986-1987."1.30Temporal trends in the progression of human immunodeficiency virus disease in a cohort of drug users. ( Buono, D; Chang, CJ; Gourevitch, MN; Klein, RS; Schoenbaum, EE; Webber, MP, 1998)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.25)18.2507
2000's7 (43.75)29.6817
2010's6 (37.50)24.3611
2020's2 (12.50)2.80

Authors

AuthorsStudies
Zhang, JY1
Li, ZB1
Zhang, L1
Wang, J1
Huang, LP1
Zhan, GL1
Li, Z1
Du, J1
Zhao, M1
Wu, KH1
Juan, SC1
Chan, CH1
Chou, SY1
Chan, HY1
Huang, C1
Ye, L1
Abdullah, AS1
Liang, B1
Jiang, J1
Ning, C1
Zang, N1
Zhang, Y1
Yang, Y1
Hu, X1
Yang, Q1
Luo, C1
Lao, F1
Liu, H1
Liang, H1
Huang, J1
Culbert, GJ1
Waluyo, A1
Wang, M1
Putri, TA1
Bazazi, AR1
Altice, FL1
Wang, L1
Wei, X1
Wang, X1
Li, J1
Li, H1
Jia, W1
Suntharasamai, P1
Martin, M1
Vanichseni, S1
van Griensven, F1
Mock, PA1
Pitisuttithum, P1
Tappero, JW1
Sangkum, U1
Kitayaporn, D1
Gurwith, M1
Choopanya, K1
Brust, JC1
Litwin, AH2
Berg, KM2
Li, X2
Heo, M2
Arnsten, JH2
Tran, BX1
Ohinmaa, A1
Mills, S1
Duong, AT1
Nguyen, LT1
Jacobs, P1
Houston, S1
De Castro, S1
Sabaté, E1
Scholten, JN1
Driver, CR1
Munsiff, SS1
Kaye, K1
Rubino, MA1
Gourevitch, MN2
Trim, C1
Amofa, J1
Seewald, R1
Highley, E1
Fujiwara, PI1
Esteban, J1
de la Cruz Pellín, M1
Gimeno, C1
Barril, J1
Mora, E1
Giménez, J1
Vilanova, E1
Raffa, JD1
Tossonian, HK1
Grebely, J1
Petkau, AJ1
DeVlaming, S1
Conway, B1
Webber, MP1
Schoenbaum, EE1
Buono, D1
Chang, CJ1
Klein, RS1
Douglas, SD1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Reducing Hepatitis C Virus (HCV)/Human Immunodeficient Virus (HIV) Risk Behaviors Among Injection Drug Users in China[NCT01647191]240 participants (Actual)Interventional2011-07-01Completed
A Phase III Trial to Determine the Efficacy of AIDSVAX B/E Vaccine in Intravenous Drug Users in Bangkok, Thailand[NCT00006327]Phase 32,500 participants Interventional1999-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

4 trials available for methadone and HIV

ArticleYear
DOES IT WORK? -a randomized controlled trial to test the efficacy of HCV and HIV-related education on drug users in MMT, China.
    BMC infectious diseases, 2019, Sep-05, Volume: 19, Issue:1

    Topics: Adult; Awareness; China; Cluster Analysis; Drug Users; Efficiency, Organizational; Female; Health Kn

2019
Factors associated with incarceration and incident human immunodeficiency virus (HIV) infection among injection drug users participating in an HIV vaccine trial in Bangkok, Thailand, 1999-2003.
    Addiction (Abingdon, England), 2009, Volume: 104, Issue:2

    Topics: Adult; AIDS Vaccines; Amphetamine-Related Disorders; Double-Blind Method; Female; HIV; HIV Infection

2009
Directly observed antiretroviral therapy in substance abusers receiving methadone maintenance therapy does not cause increased drug resistance.
    AIDS research and human retroviruses, 2011, Volume: 27, Issue:5

    Topics: Adult; Amino Acid Substitution; Analgesics, Opioid; Anti-HIV Agents; Directly Observed Therapy; Drug

2011
Lack of sustained improvement in adherence or viral load following a directly observed antiretroviral therapy intervention.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2011, Volume: 53, Issue:9

    Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Directly Observed The

2011

Other Studies

12 other studies available for methadone and HIV

ArticleYear
Factors Affecting Changes of Cluster of Differentiation 4 Cell Counts Among Human Immunodeficiency Virus-positive People Who Inject Heroin and Receive Methadone Maintenance Treatment.
    Journal of addiction medicine, 2020, Volume: 14, Issue:6

    Topics: Cell Count; Cell Differentiation; Heroin; HIV; HIV Infections; Humans; Longitudinal Studies; Methado

2020
No Increase in HIV Drug Resistance Mutations among Injecting Drug Users on Methadone Maintenance Therapy: A Prospective Cohort Study.
    Current HIV research, 2020, Volume: 18, Issue:5

    Topics: Adult; China; Cohort Studies; Drug Resistance; Drug Users; Female; HIV; HIV Infections; Humans; Main

2020
Adherence to Antiretroviral Therapy Among Incarcerated Persons with HIV: Associations with Methadone and Perceived Safety.
    AIDS and behavior, 2019, Volume: 23, Issue:8

    Topics: Adult; Antiretroviral Therapy, Highly Active; Cross-Sectional Studies; HIV; HIV Infections; Humans;

2019
Long-term effects of methadone maintenance treatment with different psychosocial intervention models.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Adult; China; Counseling; Female; Follow-Up Studies; Hepatitis C; HIV; HIV Infections; Humans; Male;

2014
Multilevel predictors of concurrent opioid use during methadone maintenance treatment among drug users with HIV/AIDS.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Adult; Analgesics, Opioid; Cohort Studies; Demography; Drug User

2012
Adherence to heroin dependence therapies and human immunodeficiency virus/acquired immunodeficiency syndrome infection rates among drug abusers.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Dec-15, Volume: 37 Suppl 5

    Topics: Acquired Immunodeficiency Syndrome; Heroin; Heroin Dependence; HIV; HIV Seroprevalence; Humans; Meth

2003
Effectiveness of isoniazid treatment for latent tuberculosis infection among human immunodeficiency virus (HIV)-infected and HIV-uninfected injection drug users in methadone programs.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Dec-15, Volume: 37, Issue:12

    Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Antitubercular Agents; Female; HIV; HIV Infectio

2003
Detection of clinical interactions between methadone and anti-retroviral compounds using an enantioselective capillary electrophoresis for methadone analysis.
    Toxicology letters, 2004, Jun-15, Volume: 151, Issue:1

    Topics: Adult; Anti-Retroviral Agents; Cocaine; Drug Interactions; Electrophoresis, Capillary; Heroin; HIV;

2004
Intermediate highly active antiretroviral therapy adherence thresholds and empirical models for the development of drug resistance mutations.
    Journal of acquired immune deficiency syndromes (1999), 2008, Mar-01, Volume: 47, Issue:3

    Topics: Adult; Antiretroviral Therapy, Highly Active; Canada; CD4 Lymphocyte Count; Drug Resistance, Viral;

2008
Southwest China opens methadone clinics in border areas to prevent spread of HIV.
    The AIDS reader, 2008, Volume: 18, Issue:3

    Topics: Ambulatory Care Facilities; China; HIV; HIV Infections; Humans; Methadone; Rural Population; Substan

2008
Temporal trends in the progression of human immunodeficiency virus disease in a cohort of drug users.
    Epidemiology (Cambridge, Mass.), 1998, Volume: 9, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Adult; Cohort Studies; Disease Progression; Female; Health Servi

1998
Methadone may promote HIV replication: study.
    AIDS alert, 2001, Volume: 16, Issue:9

    Topics: HIV; HIV Long Terminal Repeat; Humans; Methadone; Receptors, CCR5; Virus Replication

2001