methadone has been researched along with Fetal Growth Retardation in 27 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Fetal Growth Retardation: Failure of a FETUS to attain expected GROWTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to evaluate the effect of substitution therapy in heroin addicted pregnant women on the course of pregnancy, perinatal outcomes and course of the neonatal abstinence syndrome." | 9.13 | Prospective randomised comparative study of the effect of buprenorphine, methadone and heroin on the course of pregnancy, birthweight of newborns, early postpartum adaptation and course of the neonatal abstinence syndrome (NAS) in women followed up in the ( Binder, T; Vavrinková, B, 2008) |
| "Data from this non-randomized comparison suggest that buprenorphine may offer advantages for treatment of opiate dependence during pregnancy." | 7.74 | Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series. ( Heilig, M; Kakko, J; Sarman, I, 2008) |
| "The aim of the study was to analyze the neonatal impact of a methadone maintenance program in pregnancy, and the social resources of the families involved." | 7.73 | Methadone maintenance program in pregnancy in a Swiss perinatal center (II): neonatal outcome and social resources. ( Arlettaz, R; Bucher, HU; Das-Kundu, S; Fauchère, JC; Kashiwagi, M; Lang, A, 2005) |
| "The aim of the study was to evaluate the effect of substitution therapy in heroin addicted pregnant women on the course of pregnancy, perinatal outcomes and course of the neonatal abstinence syndrome." | 5.13 | Prospective randomised comparative study of the effect of buprenorphine, methadone and heroin on the course of pregnancy, birthweight of newborns, early postpartum adaptation and course of the neonatal abstinence syndrome (NAS) in women followed up in the ( Binder, T; Vavrinková, B, 2008) |
| "In our theoretical cohort, treatment of OUD with buprenorphine during pregnancy resulted in 2413 fewer cases of neonatal opioid withdrawal syndrome, 1089 fewer preterm births, 299 fewer cases of fetal growth restriction, 32 fewer stillbirths, and 13 fewer cases of cerebral palsy compared to methadone treatment." | 4.12 | Cost effectiveness of buprenorphine vs. methadone for pregnant people with opioid use disorder. ( Caughey, AB; Hersh, AR; John, C; Robin, AM, 2022) |
| "In infants of methadone-prescribed opioid-dependent mothers mean birth weight was 259 g [95% confidence interval (CI) 214-303 g; P<0." | 3.80 | Reduced fetal growth in methadone-maintained pregnancies is not fully explained by smoking or socio-economic deprivation. ( Dryden, C; Mactier, H; Shipton, D; Tappin, DM, 2014) |
| " Growth restriction was independent of the last maternal methadone dose and the cumulative methadone dose during pregnancy." | 3.76 | Growth restriction in pregnancies of opioid-dependent mothers. ( Cook, CM; Jones, MP; Liu, AJ; Nanan, R; Sithamparanathan, S, 2010) |
| "Statistically birth weight of newborns was significantly lowest in the group of heroin-addicted women as compared to the group receiving substitution with buprenorphine p<0." | 3.74 | [The effect of substitution therapy on the birth weight of the newborn, its postpartum adaptation, trophic and course of the neonatal abstinence syndrome]. ( Binder, T; Vavrinková, B, 2007) |
| "Data from this non-randomized comparison suggest that buprenorphine may offer advantages for treatment of opiate dependence during pregnancy." | 3.74 | Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series. ( Heilig, M; Kakko, J; Sarman, I, 2008) |
| "The aim of the study was to analyze the neonatal impact of a methadone maintenance program in pregnancy, and the social resources of the families involved." | 3.73 | Methadone maintenance program in pregnancy in a Swiss perinatal center (II): neonatal outcome and social resources. ( Arlettaz, R; Bucher, HU; Das-Kundu, S; Fauchère, JC; Kashiwagi, M; Lang, A, 2005) |
| " Persistent weight retardation at 12 months was correlated with methadone dosage during pregnancy, but not the need for phenobarbitone therapy." | 3.69 | Infants born to narcotic dependent mothers: physical growth patterns in the first 12 months of life. ( Chant, DC; Gray, PH; Hayes, AJ; Tudehope, DI; Vance, JC, 1997) |
| "Illicit drug abuse, as well as smoking, are known risk factors in the development of intrauterine growth retardation." | 1.28 | [Drug dependence, smoking and fetal growth retardation]. ( Hanzal, E; Hoffmann, G; Kölbl, H, 1992) |
| "There are multiple causes for intrauterine growth retardation but one etiology proposed is maternal drugs." | 1.27 | Maternal drug therapy: effect on fetal and neonatal growth and neurobehavior. ( Hill, RM; Tennyson, LM, 1986) |
| "The increased rate of prematurity, intrauterine growth retardation, and perinatal complications associated with perinatal exposure to cocaine or methamphetamine was greater than that predicted by coexisting risk factors and was consistent with the pharmacologic properties of these drugs." | 1.27 | Perinatal cocaine and methamphetamine exposure: maternal and neonatal correlates. ( Dixon, SD; Oro, AS, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (29.63) | 18.7374 |
| 1990's | 9 (33.33) | 18.2507 |
| 2000's | 6 (22.22) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Robin, AM | 1 |
| Hersh, AR | 1 |
| John, C | 1 |
| Caughey, AB | 1 |
| Mactier, H | 1 |
| Shipton, D | 1 |
| Dryden, C | 1 |
| Tappin, DM | 1 |
| Jones, HE | 1 |
| Terplan, M | 1 |
| Friedman, CJ | 1 |
| Walsh, J | 1 |
| Jansson, LM | 1 |
| Liu, AJ | 1 |
| Sithamparanathan, S | 1 |
| Jones, MP | 1 |
| Cook, CM | 1 |
| Nanan, R | 1 |
| Arlettaz, R | 1 |
| Kashiwagi, M | 1 |
| Das-Kundu, S | 1 |
| Fauchère, JC | 1 |
| Lang, A | 1 |
| Bucher, HU | 1 |
| Vavrinková, B | 2 |
| Binder, T | 2 |
| Kakko, J | 1 |
| Heilig, M | 1 |
| Sarman, I | 1 |
| Harris, VJ | 1 |
| Srinivasan, G | 1 |
| Wapner, RJ | 1 |
| Fitzsimmons, J | 1 |
| Ross, RD | 1 |
| Rudrauff, ME | 1 |
| Kurtz, AB | 1 |
| Finnegan, LP | 2 |
| Wong, WM | 1 |
| Lao, TT | 1 |
| Vance, JC | 1 |
| Chant, DC | 1 |
| Tudehope, DI | 1 |
| Gray, PH | 1 |
| Hayes, AJ | 1 |
| Cayol, V | 1 |
| Corcos, M | 1 |
| Clervoy, P | 1 |
| Speranza, M | 1 |
| Siney, C | 1 |
| Shaw, NJ | 1 |
| McCarthy, JE | 1 |
| Connaughton, JF | 1 |
| Reeser, D | 1 |
| Schut, J | 1 |
| Jones, KL | 1 |
| Chernoff, GF | 1 |
| Lam, SK | 1 |
| To, WK | 1 |
| Duthie, SJ | 1 |
| Ma, HK | 1 |
| Chang, G | 1 |
| Carroll, KM | 1 |
| Behr, HM | 1 |
| Kosten, TR | 1 |
| Hanzal, E | 1 |
| Hoffmann, G | 1 |
| Kölbl, H | 1 |
| Vering, A | 1 |
| Seeger, J | 1 |
| Becker, S | 1 |
| Halberstadt, E | 1 |
| Bender, HG | 1 |
| Kattner, E | 2 |
| Hein, PR | 1 |
| Schatorjé, JS | 1 |
| Frencken, HJ | 1 |
| Segers, MF | 1 |
| Thomas, CM | 1 |
| Maas, U | 1 |
| Koch, S | 1 |
| Schfer, A | 1 |
| Obladen, M | 1 |
| Hill, RM | 1 |
| Tennyson, LM | 1 |
| Oro, AS | 1 |
| Dixon, SD | 1 |
| Doberczak, TM | 1 |
| Thornton, JC | 1 |
| Bernstein, J | 1 |
| Kandall, SR | 1 |
| Bussolino, S | 1 |
| Tibaldi, C | 1 |
| Mansueto, MG | 1 |
| Todros, T | 1 |
| Geda, O | 1 |
| Sanfelici, C | 1 |
| Gagliardi, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407] | 55 participants (Actual) | Interventional | 2017-04-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for methadone and Fetal Growth Retardation
| Article | Year |
|---|---|
Infants of drug-dependent mothers.
Topics: Abnormalities, Drug-Induced; Female; Fetal Alcohol Spectrum Disorders; Fetal Growth Retardation; Her | 1983 |
[Pregnancy and drug abuse: current situation and therapeutic strategies].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Female; Fetal Growth Retardation; Hepatit | 2000 |
Drugs and chemicals associated with intrauterine growth deficiency.
Topics: Abnormalities, Drug-Induced; Adult; Aminopterin; Animals; Disease Models, Animal; Ethanol; Female; F | 1978 |
[Findings in newborn infants following drug abuse or drug weaning in the mother].
Topics: Abnormalities, Drug-Induced; Adult; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Inf | 1991 |
1 trial available for methadone and Fetal Growth Retardation
| Article | Year |
|---|---|
Prospective randomised comparative study of the effect of buprenorphine, methadone and heroin on the course of pregnancy, birthweight of newborns, early postpartum adaptation and course of the neonatal abstinence syndrome (NAS) in women followed up in the
Topics: Adult; Birth Weight; Buprenorphine; Female; Fetal Growth Retardation; Heroin; Heroin Dependence; Hum | 2008 |
22 other studies available for methadone and Fetal Growth Retardation
| Article | Year |
|---|---|
Cost effectiveness of buprenorphine vs. methadone for pregnant people with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Cerebral Palsy; Cost-Benefit Analysis; Female; Fetal Growth Retar | 2022 |
Reduced fetal growth in methadone-maintained pregnancies is not fully explained by smoking or socio-economic deprivation.
Topics: Adult; Analgesics, Opioid; Birth Weight; Cohort Studies; Female; Fetal Growth Retardation; Head; Hum | 2014 |
Commentary on Mactier et al. (2014): Methadone-assisted treatment and the complexity of influences on fetal development.
Topics: Analgesics, Opioid; Birth Weight; Female; Fetal Growth Retardation; Humans; Male; Methadone; Opioid- | 2014 |
Growth restriction in pregnancies of opioid-dependent mothers.
Topics: Adult; Body Mass Index; Dose-Response Relationship, Drug; Epidemiologic Methods; Female; Fetal Growt | 2010 |
Methadone maintenance program in pregnancy in a Swiss perinatal center (II): neonatal outcome and social resources.
Topics: Adult; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fetal | 2005 |
[The effect of substitution therapy on the birth weight of the newborn, its postpartum adaptation, trophic and course of the neonatal abstinence syndrome].
Topics: Apgar Score; Birth Weight; Buprenorphine; Female; Fetal Growth Retardation; Heroin Dependence; Human | 2007 |
Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series.
Topics: Birth Weight; Buprenorphine; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Infant Mor | 2008 |
A quantitative evaluation of fetal growth failure in a drug-abusing population.
Topics: Abnormalities, Drug-Induced; Female; Fetal Growth Retardation; Gestational Age; Humans; Methadone; P | 1981 |
Abnormal umbilical artery flow velocity waveform--a sign of fetal narcotic withdrawal?
Topics: Adult; Blood Flow Velocity; Cesarean Section; Female; Fetal Growth Retardation; Fetal Monitoring; He | 1997 |
Infants born to narcotic dependent mothers: physical growth patterns in the first 12 months of life.
Topics: Adult; Cohort Studies; Female; Fetal Growth Retardation; Growth; Humans; Infant; Infant, Newborn; Me | 1997 |
Methadone dependence and its effects on consecutive pregnancies.
Topics: Adolescent; Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Fetal Growth Retardation; | 2000 |
Perinatal addiction: outcome and management.
Topics: Abruptio Placentae; Apgar Score; Breech Presentation; Cesarean Section; Counseling; Female; Fetal Gr | 1977 |
Narcotic addiction in pregnancy with adverse maternal and perinatal outcome.
Topics: Adult; Female; Fetal Growth Retardation; Heroin Dependence; Hong Kong; Humans; Infant, Low Birth Wei | 1992 |
Improving treatment outcome in pregnant opiate-dependent women.
Topics: Adult; Combined Modality Therapy; Female; Fetal Growth Retardation; Follow-Up Studies; Heroin; Heroi | 1992 |
[Drug dependence, smoking and fetal growth retardation].
Topics: Acid-Base Equilibrium; Adult; Birth Weight; Drug Synergism; Female; Fetal Growth Retardation; Gestat | 1992 |
[Heroin abuse and methadone substitution in pregnancy].
Topics: Asphyxia Neonatorum; Cardiotocography; Dose-Response Relationship, Drug; Female; Fetal Growth Retard | 1992 |
The effect of chronic oral methadone treatment on monkey chorionic gonadotropin, estradiol, dehydroepiandrosterone sulfate, progesterone, prolactin and cortisol levels during pregnancy in the cynomolgus monkey (Macaca fascicularis).
Topics: Animals; Birth Weight; Chorionic Gonadotropin; Dehydroepiandrosterone; Estradiol; Female; Fetal Grow | 1991 |
[Prenatal development and postnatal morbidity of newborn infants of HIV positive mothers].
Topics: Birth Weight; Female; Fetal Growth Retardation; Gestational Age; HIV Seropositivity; Humans; Infant, | 1990 |
Maternal drug therapy: effect on fetal and neonatal growth and neurobehavior.
Topics: Aminopterin; Amphetamines; Animals; Anticoagulants; Anticonvulsants; Antihypertensive Agents; Birth | 1986 |
Perinatal cocaine and methamphetamine exposure: maternal and neonatal correlates.
Topics: Apgar Score; Birth Weight; Child Behavior; Cocaine; Female; Fetal Growth Retardation; Gestational Ag | 1987 |
Impact of maternal drug dependency on birth weight and head circumference of offspring.
Topics: Adult; Birth Weight; Female; Fetal Growth Retardation; Fetus; Head; Humans; Infant, Newborn; Methado | 1987 |
[Substance dependence and pregnancy. Experience in care].
Topics: Adult; Female; Fetal Growth Retardation; Heroin; Heroin Dependence; Humans; Methadone; Pregnancy; Pr | 1986 |