Page last updated: 2024-10-30

methadone and Fetal Death

methadone has been researched along with Fetal Death in 16 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.

Research Excerpts

ExcerptRelevanceReference
"Moderately strong evidence indicates lower risk of preterm birth, greater birth weight and larger head circumference with buprenorphine treatment of maternal opioid use disorder during pregnancy compared with methadone treatment, and no greater harms."4.93Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child. ( Amick, HR; Jones, HE; Joyce, AR; Kim, MM; Mann, AL; Murrelle, EL; Zedler, BK, 2016)
"Although methadone maintenance is the standard treatment of opiate addiction in pregnancy, opinion as to its utility is divided."3.73Methadone maintenance program in a Swiss perinatal center: (I): Management and outcome of 89 pregnancies. ( Arlettaz, R; Hebisch, G; Kashiwagi, M; Lauper, U; Zimmermann, R, 2005)
" Heroin abuse declined while methadone usage increased during those years."3.65The narcotic-dependent mother: fetal and neonatal consequences. ( Albin, S; Eidelman, A; Gartner, LM; Kandall, SR; Lee, KS; Lowinson, J, 1977)
" The same dosage levels of BP and methadone were also given to pseudopregnant rats (PSP) with an induced decidual cell reaction (DCR) in an attempt to distinguish whether adverse effects occur in the maternal or fetal compartment or both."1.27A comparative study of the reproductive effects of methadone and benzo[a]pyrene in the pregnant and pseudopregnant rat. ( Bui, QQ; Tran, MB; West, WL, 1986)
"Methadone appears to cause deficits in behavioral development which can be detected at weaning."1.26Methadone exposure in utero: effects on open-field activity in weanling rats. ( Freeman, PR, 1980)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199014 (87.50)18.7374
1990's0 (0.00)18.2507
2000's1 (6.25)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zedler, BK1
Mann, AL1
Kim, MM1
Amick, HR1
Joyce, AR1
Murrelle, EL1
Jones, HE1
Kashiwagi, M1
Arlettaz, R1
Lauper, U1
Zimmermann, R1
Hebisch, G1
Freeman, PR1
Lichtblau, L1
Sparber, SB1
Geber, WF1
Schramm, LC1
Kandall, SR1
Albin, S1
Gartner, LM1
Lee, KS1
Eidelman, A1
Lowinson, J1
Wolven, A1
Archer, S1
Connaughton, JF1
Finnegan, LP1
Schut, J1
Emich, JP1
Chandler, JM1
Robie, PW1
Schoolar, JC1
Desmond, MM1
Davis, RC1
Chappel, JN1
Mejia-Zelaya, A1
Madden, J1
Hutchings, DE1
Hunt, HF1
Towey, JP1
Rosen, TS1
Gorinson, HS1
Ellwood, DA1
Sutherland, P1
Kent, C1
O'Connor, M1
Bui, QQ1
Tran, MB1
West, WL1
Blinick, G2
Jerez, E1
Wallach, RC1
Buchenauer, D1
Turnbow, M1
Peters, MA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal Symptomatology[NCT03740243]Phase 40 participants (Actual)Interventional2018-11-30Withdrawn (stopped due to No enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for methadone and Fetal Death

ArticleYear
Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child.
    Addiction (Abingdon, England), 2016, Volume: 111, Issue:12

    Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Fetal Death; F

2016
Toxicology of LAAM.
    NIDA research monograph, 1976, Issue:8

    Topics: Animals; Behavior, Animal; Body Weight; Dogs; Dose-Response Relationship, Drug; Drinking; Drug Admin

1976

Other Studies

14 other studies available for methadone and Fetal Death

ArticleYear
Methadone maintenance program in a Swiss perinatal center: (I): Management and outcome of 89 pregnancies.
    Acta obstetricia et gynecologica Scandinavica, 2005, Volume: 84, Issue:2

    Topics: Adult; Birth Weight; Cocaine-Related Disorders; Cohort Studies; Dose-Response Relationship, Drug; Dr

2005
Methadone exposure in utero: effects on open-field activity in weanling rats.
    The International journal of neuroscience, 1980, Volume: 11, Issue:4

    Topics: Animals; Animals, Suckling; Birth Weight; Dose-Response Relationship, Drug; Exploratory Behavior; Fe

1980
Opiate withdrawal in utero increases neonatal morbidity in the rat.
    Science (New York, N.Y.), 1981, May-22, Volume: 212, Issue:4497

    Topics: Animals; Drug Tolerance; Embryo Implantation; Female; Fetal Death; Humans; Litter Size; Methadone; M

1981
Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster.
    American journal of obstetrics and gynecology, 1975, Dec-01, Volume: 123, Issue:7

    Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Animals; Central Nervous System; Female; Fetal Deat

1975
The narcotic-dependent mother: fetal and neonatal consequences.
    Early human development, 1977, Volume: 1, Issue:2

    Topics: Adult; Female; Fetal Death; Fetus; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Inf

1977
Current concepts in the management of the pregnant opiate addict.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Administration, Oral; Anesthesia, Conduction; Anesthesia, Obstetrical; Birth Weight; Counseling; Fem

1975
The effects of methadone on maternal-fetal interactions in the rat.
    The Journal of pharmacology and experimental therapeutics, 1975, Volume: 192, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dose-Response Relationship, Drug; Female; Fetal D

1975
Clinical observations on methadone-maintained pregnancies.
    Addictive diseases, 1975, Volume: 2, Issue:1-2

    Topics: Administration, Oral; Adult; Birth Weight; Counseling; Dose-Response Relationship, Drug; Female; Fet

1975
Methadone during pregnancy in the rat: dose level effects on maternal and perinatal mortality and growth in the offspring.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 197, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Body Weight; Female; Fetal Death; Fetus; Gestati

1976
Maternal narcotic addiction: pregnancy outcome in patients managed by a specialized drug-dependency antenatal clinic.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1987, Volume: 27, Issue:2

    Topics: Adolescent; Adult; Female; Fetal Death; Health Facilities; Heroin Dependence; Humans; Infant, Newbor

1987
A comparative study of the reproductive effects of methadone and benzo[a]pyrene in the pregnant and pseudopregnant rat.
    Toxicology, 1986, Dec-15, Volume: 42, Issue:2-3

    Topics: Animals; Benzo(a)pyrene; Female; Fetal Death; Fetal Resorption; Litter Size; Methadone; Nucleotides,

1986
Methadone maintenance, pregnancy, and progeny.
    JAMA, 1973, Jul-30, Volume: 225, Issue:5

    Topics: Administration, Oral; Adult; Apgar Score; Birth Weight; Female; Fetal Death; Heroin; Heroin Dependen

1973
Effect of chronic methadone adminstration on pregnant rats and their offspring.
    The Journal of pharmacology and experimental therapeutics, 1974, Volume: 189, Issue:1

    Topics: Animals; Animals, Newborn; Body Weight; Embryonic and Fetal Development; Female; Fertility; Fetal De

1974
Menstrual function and pregnancy in narcotics addicts treated with methadone.
    Nature, 1968, Jul-13, Volume: 219, Issue:5150

    Topics: Abortion, Spontaneous; Adult; Amenorrhea; Female; Fetal Death; Humans; Infant, Newborn; Menstruation

1968