methadone has been researched along with Fetal Death in 16 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Moderately strong evidence indicates lower risk of preterm birth, greater birth weight and larger head circumference with buprenorphine treatment of maternal opioid use disorder during pregnancy compared with methadone treatment, and no greater harms." | 4.93 | Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child. ( Amick, HR; Jones, HE; Joyce, AR; Kim, MM; Mann, AL; Murrelle, EL; Zedler, BK, 2016) |
| "Although methadone maintenance is the standard treatment of opiate addiction in pregnancy, opinion as to its utility is divided." | 3.73 | Methadone maintenance program in a Swiss perinatal center: (I): Management and outcome of 89 pregnancies. ( Arlettaz, R; Hebisch, G; Kashiwagi, M; Lauper, U; Zimmermann, R, 2005) |
| " Heroin abuse declined while methadone usage increased during those years." | 3.65 | The narcotic-dependent mother: fetal and neonatal consequences. ( Albin, S; Eidelman, A; Gartner, LM; Kandall, SR; Lee, KS; Lowinson, J, 1977) |
| " The same dosage levels of BP and methadone were also given to pseudopregnant rats (PSP) with an induced decidual cell reaction (DCR) in an attempt to distinguish whether adverse effects occur in the maternal or fetal compartment or both." | 1.27 | A comparative study of the reproductive effects of methadone and benzo[a]pyrene in the pregnant and pseudopregnant rat. ( Bui, QQ; Tran, MB; West, WL, 1986) |
| "Methadone appears to cause deficits in behavioral development which can be detected at weaning." | 1.26 | Methadone exposure in utero: effects on open-field activity in weanling rats. ( Freeman, PR, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (87.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zedler, BK | 1 |
| Mann, AL | 1 |
| Kim, MM | 1 |
| Amick, HR | 1 |
| Joyce, AR | 1 |
| Murrelle, EL | 1 |
| Jones, HE | 1 |
| Kashiwagi, M | 1 |
| Arlettaz, R | 1 |
| Lauper, U | 1 |
| Zimmermann, R | 1 |
| Hebisch, G | 1 |
| Freeman, PR | 1 |
| Lichtblau, L | 1 |
| Sparber, SB | 1 |
| Geber, WF | 1 |
| Schramm, LC | 1 |
| Kandall, SR | 1 |
| Albin, S | 1 |
| Gartner, LM | 1 |
| Lee, KS | 1 |
| Eidelman, A | 1 |
| Lowinson, J | 1 |
| Wolven, A | 1 |
| Archer, S | 1 |
| Connaughton, JF | 1 |
| Finnegan, LP | 1 |
| Schut, J | 1 |
| Emich, JP | 1 |
| Chandler, JM | 1 |
| Robie, PW | 1 |
| Schoolar, JC | 1 |
| Desmond, MM | 1 |
| Davis, RC | 1 |
| Chappel, JN | 1 |
| Mejia-Zelaya, A | 1 |
| Madden, J | 1 |
| Hutchings, DE | 1 |
| Hunt, HF | 1 |
| Towey, JP | 1 |
| Rosen, TS | 1 |
| Gorinson, HS | 1 |
| Ellwood, DA | 1 |
| Sutherland, P | 1 |
| Kent, C | 1 |
| O'Connor, M | 1 |
| Bui, QQ | 1 |
| Tran, MB | 1 |
| West, WL | 1 |
| Blinick, G | 2 |
| Jerez, E | 1 |
| Wallach, RC | 1 |
| Buchenauer, D | 1 |
| Turnbow, M | 1 |
| Peters, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal Symptomatology[NCT03740243] | Phase 4 | 0 participants (Actual) | Interventional | 2018-11-30 | Withdrawn (stopped due to No enrollment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for methadone and Fetal Death
| Article | Year |
|---|---|
Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Fetal Death; F | 2016 |
Toxicology of LAAM.
Topics: Animals; Behavior, Animal; Body Weight; Dogs; Dose-Response Relationship, Drug; Drinking; Drug Admin | 1976 |
14 other studies available for methadone and Fetal Death
| Article | Year |
|---|---|
Methadone maintenance program in a Swiss perinatal center: (I): Management and outcome of 89 pregnancies.
Topics: Adult; Birth Weight; Cocaine-Related Disorders; Cohort Studies; Dose-Response Relationship, Drug; Dr | 2005 |
Methadone exposure in utero: effects on open-field activity in weanling rats.
Topics: Animals; Animals, Suckling; Birth Weight; Dose-Response Relationship, Drug; Exploratory Behavior; Fe | 1980 |
Opiate withdrawal in utero increases neonatal morbidity in the rat.
Topics: Animals; Drug Tolerance; Embryo Implantation; Female; Fetal Death; Humans; Litter Size; Methadone; M | 1981 |
Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Animals; Central Nervous System; Female; Fetal Deat | 1975 |
The narcotic-dependent mother: fetal and neonatal consequences.
Topics: Adult; Female; Fetal Death; Fetus; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Inf | 1977 |
Current concepts in the management of the pregnant opiate addict.
Topics: Administration, Oral; Anesthesia, Conduction; Anesthesia, Obstetrical; Birth Weight; Counseling; Fem | 1975 |
The effects of methadone on maternal-fetal interactions in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dose-Response Relationship, Drug; Female; Fetal D | 1975 |
Clinical observations on methadone-maintained pregnancies.
Topics: Administration, Oral; Adult; Birth Weight; Counseling; Dose-Response Relationship, Drug; Female; Fet | 1975 |
Methadone during pregnancy in the rat: dose level effects on maternal and perinatal mortality and growth in the offspring.
Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Body Weight; Female; Fetal Death; Fetus; Gestati | 1976 |
Maternal narcotic addiction: pregnancy outcome in patients managed by a specialized drug-dependency antenatal clinic.
Topics: Adolescent; Adult; Female; Fetal Death; Health Facilities; Heroin Dependence; Humans; Infant, Newbor | 1987 |
A comparative study of the reproductive effects of methadone and benzo[a]pyrene in the pregnant and pseudopregnant rat.
Topics: Animals; Benzo(a)pyrene; Female; Fetal Death; Fetal Resorption; Litter Size; Methadone; Nucleotides, | 1986 |
Methadone maintenance, pregnancy, and progeny.
Topics: Administration, Oral; Adult; Apgar Score; Birth Weight; Female; Fetal Death; Heroin; Heroin Dependen | 1973 |
Effect of chronic methadone adminstration on pregnant rats and their offspring.
Topics: Animals; Animals, Newborn; Body Weight; Embryonic and Fetal Development; Female; Fertility; Fetal De | 1974 |
Menstrual function and pregnancy in narcotics addicts treated with methadone.
Topics: Abortion, Spontaneous; Adult; Amenorrhea; Female; Fetal Death; Humans; Infant, Newborn; Menstruation | 1968 |