methadone has been researched along with Encephalopathy, Toxic in 11 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we report a patient who developed acute bilateral hearing loss, ataxia and paraparesis subsequently to intravenous methadone-abuse." | 4.02 | Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments. ( Haessner, S; Johnen, A; Landmeyer, NC; Meyer Zu Hörste, G; Pawlitzki, M; Repple, J; Schulte-Mecklenbeck, A; Wiendl, H, 2021) |
| "Methadone use as a second-line agent for severe cancer-related pain is increasing in the field of hospice and palliative care." | 3.85 | Methadone-Induced Neurotoxicity in Advanced Cancer: A Case Report. ( Hartwig, KN; Hoff, AM; Rosielle, DA, 2017) |
| "Methadone-induced toxic encephalopathy is an extremely rare form of toxic encephalopathy which typically demonstrates abnormal imaging findings in the dentate nuclei or cerebellum." | 1.51 | Methadone-induced Toxic Encephalopathy In Pediatric Patients: Two Case Reports. ( Chieng, JSL; Khoo, HW; Ng, CH; Tiong, SC, 2019) |
| "These findings represent a toxic encephalopathy and have been reported in previous cases of heroin intoxication by inhalation, but rarely following opioid ingestion." | 1.35 | Severe cerebellitis following methadone poisoning. ( Devile, CJ; MacLennan, SC; Mills, F; Saunders, DE, 2008) |
| "Methadone is a synthetic opioid agonist and N-methyl-D-aspartate (NMDA) receptor antagonist that is being increasingly used in pain management, particularly for pain that is resistant to conventional opioids." | 1.33 | Rotation to methadone after opioid dose escalation: How should individualization of dosing occur? ( Booth, CM; Cottrell, W; Seccareccia, D; Zimmermann, C, 2005) |
| "The methadone solution was heated in an aluminum pot to reduce the volume and then injected intravenously (IV)." | 1.33 | Aluminum toxicity following IV use of oral methadone solution. ( Friesen, MS; Gair, RD; Purssell, RA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Tiong, SC | 1 |
| Chieng, JSL | 1 |
| Khoo, HW | 1 |
| Ng, CH | 1 |
| Repple, J | 1 |
| Haessner, S | 1 |
| Johnen, A | 1 |
| Landmeyer, NC | 1 |
| Schulte-Mecklenbeck, A | 1 |
| Pawlitzki, M | 1 |
| Wiendl, H | 1 |
| Meyer Zu Hörste, G | 1 |
| Hoff, AM | 1 |
| Hartwig, KN | 1 |
| Rosielle, DA | 1 |
| Razmkon, A | 1 |
| Bakhtazad, A | 1 |
| Zanin, A | 1 |
| Masiero, S | 1 |
| Severino, MS | 1 |
| Calderone, M | 1 |
| Da Dalt, L | 1 |
| Laverda, AM | 1 |
| Yuan, W | 1 |
| Williams, BN | 1 |
| Chung, KS | 1 |
| Carson, S | 1 |
| Glassman, D | 1 |
| Vadivelu, N | 1 |
| Zimmermann, C | 1 |
| Seccareccia, D | 1 |
| Booth, CM | 1 |
| Cottrell, W | 1 |
| Friesen, MS | 1 |
| Purssell, RA | 1 |
| Gair, RD | 1 |
| Anselmo, M | 1 |
| Campos Rainho, A | 1 |
| do Carmo Vale, M | 1 |
| Estrada, J | 1 |
| Valente, R | 1 |
| Correia, M | 1 |
| Vieira, JP | 1 |
| Barata, D | 1 |
| Mills, F | 1 |
| MacLennan, SC | 1 |
| Devile, CJ | 1 |
| Saunders, DE | 1 |
11 other studies available for methadone and Encephalopathy, Toxic
| Article | Year |
|---|---|
Methadone-induced Toxic Encephalopathy In Pediatric Patients: Two Case Reports.
Topics: Analgesics, Opioid; Cerebellar Diseases; Child, Preschool; Diffusion Magnetic Resonance Imaging; Enc | 2019 |
Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments.
Topics: Administration, Intravenous; Analgesics, Opioid; Ataxia; Brain; Brain Diseases; Brain Edema; Cogniti | 2021 |
Methadone-Induced Neurotoxicity in Advanced Cancer: A Case Report.
Topics: Analgesics, Opioid; Humans; Male; Methadone; Middle Aged; Neoplasms; Neurotoxicity Syndromes; Pain; | 2017 |
Possible mechanisms of rapid neurological deterioration and acute hydrocephalus in drug abusers.
Topics: Cerebellar Diseases; Child, Preschool; Diagnosis, Differential; Female; Humans; Magnetic Resonance I | 2009 |
A delayed methadone encephalopathy: clinical and neuroradiological findings.
Topics: Brain; Child, Preschool; Encephalitis; Female; Humans; Magnetic Resonance Imaging; Methadone; Neurol | 2010 |
Naloxone successfully counters life-threatening toxicity of benzodiazepine in a patient in methadone-maintenance treatment.
Topics: Benzodiazepines; Heroin Dependence; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Narcoti | 2012 |
Successful treatment of hydromorphone-induced neurotoxicity and hyperalgesia.
Topics: Humans; Hydromorphone; Hyperalgesia; Male; Methadone; Middle Aged; Narcotics; Neurotoxicity Syndrome | 2004 |
Rotation to methadone after opioid dose escalation: How should individualization of dosing occur?
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Hydromorphone; Methadone; Midd | 2005 |
Aluminum toxicity following IV use of oral methadone solution.
Topics: Adult; Aluminum; Chelating Agents; Deferoxamine; Humans; Injections, Intravenous; Male; Methadone; N | 2006 |
Methadone intoxication in a child: toxic encephalopathy?
Topics: Analgesics, Opioid; Brain Diseases; Child, Preschool; Humans; Male; Methadone; Neurotoxicity Syndrom | 2006 |
Severe cerebellitis following methadone poisoning.
Topics: Cerebellar Diseases; Child, Preschool; Diagnosis, Differential; Female; Humans; Magnetic Resonance I | 2008 |