methadone has been researched along with Emesis in 20 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of ondansetron 4 mg was compared with metoclopramide 10 mg for the prevention of post-operative nausea and vomiting in patients after major gynaecological abdominal surgery." | 9.08 | Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery. ( Chen, PP; Chui, PT; Gin, T, 1996) |
| "The effect of morphine, methadone and pethidine injected into the cerebral ventricle of the unanesthetized cat upon emesis produced by nicotine induced similarly was investigated." | 7.66 | Inhibition by morphine and morphine-like drugs of nicotine-induced emesis in cats. ( Beleslin, DB; Krstić, SK; Mićić, D; Stefanović-Denić, K; Strbac, M, 1981) |
| "To compare the effects of morphine (MOR), methadone (MET), butorphanol (BUT) and tramadol (TRA), in combination with acepromazine, on sedation, cardiorespiratory variables, body temperature and incidence of emesis in dogs." | 5.14 | Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine, in dogs. ( Assis, HM; Campagnol, D; Junior, AR; Monteiro, ER; Quitzan, JG, 2009) |
| "The efficacy of ondansetron 4 mg was compared with metoclopramide 10 mg for the prevention of post-operative nausea and vomiting in patients after major gynaecological abdominal surgery." | 5.08 | Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery. ( Chen, PP; Chui, PT; Gin, T, 1996) |
| "The effect of morphine, methadone and pethidine injected into the cerebral ventricle of the unanesthetized cat upon emesis produced by nicotine induced similarly was investigated." | 3.66 | Inhibition by morphine and morphine-like drugs of nicotine-induced emesis in cats. ( Beleslin, DB; Krstić, SK; Mićić, D; Stefanović-Denić, K; Strbac, M, 1981) |
| " Narcotics are used for the euphoria they provide; however, chronic use results in physiological and psychological changes." | 2.37 | Narcotic withdrawal in the emergency department. ( Freitas, PM, 1985) |
| " The median elimination half-life of methadone in healthy subjects was 33-46 h depending on the method used to calculate this parameter." | 1.30 | The pharmacokinetics of methadone in healthy subjects and opiate users. ( Calvert, R; Feely, M; Hay, AW; Raistrick, D; Rostami-Hodjegan, A; Shires, S; Tucker, GT; Wolff, K, 1997) |
| "To assess the effect of opioid substitution (substituting one member of the opioid class for another) on the incidence and severity of adverse effects in palliative care patients who experience unacceptable, refractory adverse effects when taking an opioid drug." | 1.30 | Opioid substitution to reduce adverse effects in cancer pain management. ( Ashby, MA; Jackson, KA; Martin, P, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (65.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bonnet, U | 1 |
| Stratmann, U | 1 |
| Isbruch, K | 1 |
| Monteiro, ER | 1 |
| Junior, AR | 1 |
| Assis, HM | 1 |
| Campagnol, D | 1 |
| Quitzan, JG | 1 |
| Beleslin, DB | 1 |
| Krstić, SK | 1 |
| Stefanović-Denić, K | 1 |
| Strbac, M | 1 |
| Mićić, D | 1 |
| Hyndman, J | 1 |
| Chen, PP | 1 |
| Chui, PT | 2 |
| Gin, T | 2 |
| Wolff, K | 1 |
| Rostami-Hodjegan, A | 1 |
| Shires, S | 1 |
| Hay, AW | 1 |
| Feely, M | 1 |
| Calvert, R | 1 |
| Raistrick, D | 1 |
| Tucker, GT | 1 |
| Ashby, MA | 1 |
| Martin, P | 1 |
| Jackson, KA | 1 |
| Lal, H | 1 |
| Gianutsos, G | 1 |
| Puri, SK | 1 |
| Zelson, C | 1 |
| Kampehl, HJ | 1 |
| Benad, G | 1 |
| Freitas, PM | 1 |
| Grosz, HJ | 1 |
| Vandam, LD | 1 |
| Kerr, F | 1 |
| Donald, KW | 1 |
| Holcenberg, JS | 1 |
| Dundee, JW | 2 |
| Jones, PO | 1 |
| Reddy, AM | 1 |
| Harper, RG | 1 |
| Stern, G | 1 |
| Loan, WB | 1 |
| Morrison, JD | 1 |
| Tamarkin, NR | 1 |
| Goodwin, FK | 1 |
| Axelrod, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325] | Phase 3 | 24 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Does Intraoperative Methadone Prevent Postoperative Pain in Bariatric Surgery?[NCT02775474] | Phase 4 | 32 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Clinical Effectiveness and Safety of Intraoperative Methadone in Patients Undergoing Laparoscopic Hysterectomy: a Prospective, Double-blind, Randomised Controlled Trial[NCT03908060] | 126 participants (Actual) | Interventional | 2019-05-06 | Active, not recruiting | |||
| The Effect of Methadone on Perioperative Analgesia After Posterior Lumbar Fusion - A Randomized, Placebo-controlled, Double-blinded Study[NCT01125059] | 0 participants (Actual) | Interventional | 2010-05-31 | Withdrawn (stopped due to Unable to fulfill recruitment) | |||
| The Influence of Pharmacogenetics on Methadone Dose, Safety, and Outcomes After Spine Fusion[NCT01677650] | Phase 1 | 0 participants (Actual) | Interventional | 2014-03-31 | Withdrawn (stopped due to Investigator moved to new institution) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for methadone and Emesis
| Article | Year |
|---|---|
Narcotic withdrawal in the emergency department.
Topics: Clonidine; Emergency Service, Hospital; Endorphins; Humans; Methadone; Narcotics; Nervous System Dis | 1985 |
Drug therapy: analgetic drugs--the potent analgetics.
Topics: Analgesics; Blood Circulation; Fentanyl; Humans; Intestines; Levallorphan; Meperidine; Methadone; Me | 1972 |
Editorial: Analgesia in myocardial infarction.
Topics: Analgesia; Analgesics; Animals; Blood Pressure; Cyclizine; Heart Arrest; Heroin; Humans; Injections, | 1974 |
5 trials available for methadone and Emesis
| Article | Year |
|---|---|
Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine, in dogs.
Topics: Acepromazine; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Body T | 2009 |
Comparison of ondansetron and metoclopramide for the prevention of post-operative nausea and vomiting after major gynaecological surgery.
Topics: Adolescent; Adult; Analgesics, Opioid; Antiemetics; Double-Blind Method; Female; Humans; Hysterectom | 1996 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
A double-blind randomised trial comparing postoperative analgesia after perioperative loading doses of methadone or morphine.
Topics: Adult; Analgesia; Double-Blind Method; Female; Heart Rate; Humans; Hysterectomy; Injections, Intrave | 1992 |
Narcotic withdrawal symptoms in heroin users treated with propranolol.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Clinical Trials as Topic; Female; Heroin; Hu | 1972 |
The prevention of analgesic-induced nausea and vomiting by cyclizine.
Topics: Analgesia; Clinical Trials as Topic; Codeine; Cyclizine; Female; Humans; Levorphanol; Male; Meperidi | 1968 |
12 other studies available for methadone and Emesis
| Article | Year |
|---|---|
[No opiates against cannabis hyperemesis syndrome].
Topics: Adult; Antiemetics; Dronabinol; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combina | 2014 |
Inhibition by morphine and morphine-like drugs of nicotine-induced emesis in cats.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Emetics; Female; Injections, Intraventricular; Male | 1981 |
Oral premedication with methadone, promethazine and diclofenac.
Topics: Administration, Oral; Anxiety; Diclofenac; Female; Humans; Male; Methadone; Pain, Postoperative; Pre | 1993 |
The pharmacokinetics of methadone in healthy subjects and opiate users.
Topics: Adolescent; Adult; Biological Availability; Female; Half-Life; Humans; Male; Metabolic Clearance Rat | 1997 |
Opioid substitution to reduce adverse effects in cancer pain management.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hospice Care; Humans; Male; Medical A | 1999 |
A comparison of narcotic analgesics with neuroleptics on behavioral measures of dopaminergic activity.
Topics: Aggression; Amphetamine; Analgesics, Opioid; Animals; Apomorphine; Behavior, Animal; Brain; Cataleps | 1975 |
Acute management of neonatal addiction.
Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant | 1975 |
[Dipidolor (piritramid)--a new morphine-like analgesic].
Topics: Analgesics; Drug Evaluation; Humans; Methadone; Respiration; Vomiting | 1975 |
Treatment of overdose and withdrawal of abused drugs.
Topics: Amphetamine; Cathartics; Charcoal; Diuretics; Gastric Lavage; Hallucinogens; Humans; Hypnotics and S | 1973 |
Observations on heroin and methadone withdrawal in the newborn.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Heroin; Humans; Infant, Newborn; Infant, Newbo | 1971 |
Studies of drugs given before anaesthesia. XIX. The opiates.
Topics: Analgesics; Diazepam; Female; Fentanyl; Heroin; Humans; Levorphanol; Male; Meperidine; Methadone; Mo | 1970 |
Rapid elevation of biogenic amine metabolites in human CSF following probenecid.
Topics: Administration, Oral; Affective Symptoms; Dihydroxyphenylalanine; Female; Headache; Humans; Hydroxyi | 1970 |