methadone has been researched along with Drug Withdrawal Symptoms in 1094 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One of the most efficacious treatments for cocaine abuse is contingency management (CM), but little research has explored the impact of AD on abstinence outcomes, particularly among patients in methadone maintenance." | 9.15 | Concurrent alcohol dependence among methadone-maintained cocaine abusers is associated with greater abstinence. ( Byrne, SA; Petry, NM, 2011) |
| "To evaluate the efficacy of methylnaltrexone, the first peripheral opioid receptor antagonist, in treating chronic methadone-induced constipation." | 9.09 | Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial. ( Foss, JF; Karrison, T; Moss, J; O'Connor, M; Osinski, J; Roizen, MF; Yuan, CS, 2000) |
| "This research evaluated the efficacy of an Anxiety Reduction program designed to reduce anxiety early in methadone detoxification and thereby facilitate dose reduction." | 9.05 | Methadone dose decreases and anxiety reduction. ( Hall, SM; Kushner, M; Loeb, PC, 1984) |
| " Thus, the present study aimed to investigate whether the damaging effects of morphine dependence were reversed by the spontaneous morphine withdrawal or incubation with methadone and/or naloxone in Sertoli (TM4) cells using an in- vitro cell model of morphine dependence." | 8.02 | Morphine dependence and withdrawal-induced changes in mouse Sertoli cell (TM4) line: Evaluation of apoptotic, inflammatory and oxidative stress biomarkers. ( Miladi-Gorji, H; Pourhassanali, N; Zarbakhsh, S, 2021) |
| "This study was designed to examine whether treadmill exercise would attenuate the severity of physical dependence, methadone-induced anxiety, depression and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment (MMT)." | 7.88 | Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment. ( Alizadeh, M; Miladi-Gorji, H; Zahedi-Khorasani, M, 2018) |
| " Factors influencing adherence to buprenorphine during pregnancy have not been identified." | 7.88 | Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence. ( Catlin, D; Coker, JL; Knight, B; Ray-Griffith, S; Stowe, ZN, 2018) |
| "To identify maternal and neonatal factors that impact response to methadone therapy for neonatal abstinence syndrome." | 7.77 | Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. ( Akinbi, H; Isemann, B; Meinzen-Derr, J, 2011) |
| "To report the occurrence of bradycardia associated with the use of methadone administered to prevent withdrawal in an infant with physical tolerance following long-term opioid therapy in the pediatric intensive care unit setting." | 7.73 | Bradycardia during methadone therapy in an infant. ( Tobias, JD; Wheeler, AD, 2006) |
| "To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy." | 7.72 | Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004) |
| "The volume of feeds, changes in infant body weight, as well as occurrence of adverse clinical effects in infants withdrawing from methadone were studied during the first month of life." | 7.70 | Hyperphagia in neonates withdrawing from methadone. ( Kastner, B; Martinez, A; Taeusch, HW, 1999) |
| "An atypical depression, resembling beta-phenylethylamine (PEA) deficiency states, frequently complicates methadone withdrawal." | 7.67 | Depression during methadone withdrawal: no role for beta-phenylethylamine. ( Chuang, LW; Karoum, F; Kaufmann, CA; Kreek, MJ, 1984) |
| "The authors describe their experience with methadone treatment in pregnancy." | 7.67 | Methadone in pregnancy: clinical-toxicological aspects. ( Chiarotti, M; De Giovanni, N; Falasconi, AM; Offidani, C, 1986) |
| "The course of pregnancy and delivery in 28 women under closely supervised methadone maintenance (group 1) was compared with that of 57 women using heroin or methadone under less controlled circumstances (group 2) and with that of 30 women free of mood-altering medications (group 3)." | 7.65 | Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs. ( Adamsons, K; Stimmel, B, 1976) |
| "Methadone is a synthetic opioid that binds to the κ-opioid receptor with a low affinity." | 6.79 | The association of genetic polymorphisms in the κ-opioid receptor 1 gene with body weight, alcohol use, and withdrawal symptoms in patients with methadone maintenance. ( Chang, YS; Chen, AC; Chen, CH; Chung, RH; Fang, CP; Ho, IK; Hsiao, CF; Huang, BH; Kuo, HW; Lin, KM; Liu, SC; Liu, YL; Shih, YH; Tsou, HH; Wang, SC; Wu, HY, 2014) |
| " Although these specific dosing procedures would not necessarily be used in clinical settings, they provide a procedural template that might be applied safely and effectively with a broader range of treatment-seeking individuals." | 6.72 | Early impact of methadone induction for heroin dependence: differential effects of two dose sequences in a randomized controlled study. ( Greenwald, MK, 2006) |
| "Methadone patients had lower baseline MHPG levels." | 6.70 | Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients. ( Charney, DS; Kosten, TR; Krystal, JH; Petrakis, IL; Southwick, SM; Stine, SM, 2002) |
| "A retrospective, inception cohort, nonrandomized control design was employed to evaluate the effects of daily vs twice daily dosing of methadone on opiate/cocaine use, and noncompliance with urine toxicology requests in methadone-maintained pregnant women, n = 45." | 6.68 | Methadone dosing and pregnancy: impact on program compliance. ( DePetrillo, PB; Rice, JM, 1995) |
| "Menopause is a natural process that occurs in women's lives as part of normal aging." | 5.34 | Exploring the prevalence of menopause symptoms in midlife women in methadone maintenance treatment. ( Tuchman, E, 2007) |
| "Induction onto buprenorphine during pregnancy may be more challenging than induction onto methadone." | 5.17 | Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention. ( Coyle, MG; Fischer, G; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; Stine, SM, 2013) |
| "Opioid detoxification is not an effective stand-alone treatment for heroin dependence but is nevertheless an essential step in the path to recovery." | 5.15 | Outpatient versus inpatient opioid detoxification: a randomized controlled trial. ( Day, E; Strang, J, 2011) |
| " One of the most efficacious treatments for cocaine abuse is contingency management (CM), but little research has explored the impact of AD on abstinence outcomes, particularly among patients in methadone maintenance." | 5.15 | Concurrent alcohol dependence among methadone-maintained cocaine abusers is associated with greater abstinence. ( Byrne, SA; Petry, NM, 2011) |
| "Methadone maintenance has been an effective pharmacotherapy for the treatment of heroin dependence for nearly four decades." | 5.11 | Methadone doses of 100 mg or greater are more effective than lower doses at suppressing heroin self-administration in opioid-dependent volunteers. ( Bigelow, GE; Brasser, SM; Donny, EC; Stitzer, ML; Walsh, SL, 2005) |
| "To evaluate the efficacy of methylnaltrexone, the first peripheral opioid receptor antagonist, in treating chronic methadone-induced constipation." | 5.09 | Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial. ( Foss, JF; Karrison, T; Moss, J; O'Connor, M; Osinski, J; Roizen, MF; Yuan, CS, 2000) |
| " During general anesthesia lasting about six hours with methohexital or propofol, naloxone was administered with doubling of the dose every 15 minutes with a starting bolus dose of 0." | 5.08 | Alternative strategies of opiate detoxification: evaluation of the so-called ultra-rapid detoxification. ( Gastpar, M; Kaube, H; Kienbaum, P; Klein, S; Peters, J; Scherbaum, N, 1998) |
| "Clonidine's actions and efficacy in mental disorders are reviewed and examined." | 5.06 | Psychiatric indications for clonidine: the neuropharmacologic and clinical basis. ( Bond, WS, 1986) |
| "This research evaluated the efficacy of an Anxiety Reduction program designed to reduce anxiety early in methadone detoxification and thereby facilitate dose reduction." | 5.05 | Methadone dose decreases and anxiety reduction. ( Hall, SM; Kushner, M; Loeb, PC, 1984) |
| "We included all studies of methadone used to facilitate weaning from continuous opioid infusions in pediatric critical care patients, including medical, cardiac, and surgical patients, excluding case reports and studies treating neonatal abstinence syndrome, or acute or chronic pain." | 4.95 | The use of methadone to facilitate opioid weaning in pediatric critical care patients: a systematic review of the literature and meta-analysis. ( Dervan, LA; Watson, RS; Wolf, FM; Yaghmai, B, 2017) |
| " In the United States there are medications available to treat tobacco use disorders (nicotine replacement, bupropion, and varenicline), alcohol use disorders (naltrexone and acamprosate), and opioid use disorders (methadone and buprenorphine)." | 4.93 | Pharmacotherapy for Substance Use Disorders. ( Klein, JW, 2016) |
| " In this commentary, we briefly summarize the extant literature on pharmacotherapies in opioid-maintained smokers and contribute new data investigating the contribution of bupropion on smoking outcomes in 81 methadone- and buprenorphine-maintained participants from two randomized trials of financial incentives for smoking cessation." | 4.91 | Are Pharmacotherapies Ineffective in Opioid-Dependent Smokers? Reflections on the Scientific Literature and Future Directions. ( Miller, ME; Sigmon, SC, 2015) |
| "Methadone is prescribed in France as a maintenance treatment for heroin dependence since 1969." | 4.89 | [When and how to detoxify clients from methadone maintenance treatment?]. ( Bloch, V; Dugarin, J; Dupuy, G; Ksouda, K; Laqueille, X; Lépine, JP; Vorspan, F, 2013) |
| " However, concerns about neonatal abstinence syndrome (NAS) in methadone-exposed neonates have resulted in efforts to withdraw women from methadone during pregnancy or to use buprenorphine, a mixed agonist/antagonist opiate in place of methadone." | 4.88 | Intrauterine abstinence syndrome (IAS) during buprenorphine inductions and methadone tapers: can we assure the safety of the fetus? ( McCarthy, JJ, 2012) |
| "Methadone hydrochloride is a mu-opioid agonist that has been used for the treatment of pain and for the management and maintenance of opioid withdrawal for over 50 years." | 4.81 | Clinical use of methadone. ( Goode, JV; Layson-Wolf, C; Small, RE, 2002) |
| " Opioid exposure during pregnancy included 16 202 pregnancies exposed to codeine, 4540 to oxycodone, 1244 to tramadol, 260 to methadone (dispensed for pain), 90 to hydromorphone, and 63 to morphine compared with 25 710 exposed to hydrocodone." | 4.12 | Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns. ( Bateman, BT; Esposito, DB; Hernández-Díaz, S; Huybrechts, KF; Mogun, H; Straub, L; Werler, MM, 2022) |
| " Thus, the present study aimed to investigate whether the damaging effects of morphine dependence were reversed by the spontaneous morphine withdrawal or incubation with methadone and/or naloxone in Sertoli (TM4) cells using an in- vitro cell model of morphine dependence." | 4.02 | Morphine dependence and withdrawal-induced changes in mouse Sertoli cell (TM4) line: Evaluation of apoptotic, inflammatory and oxidative stress biomarkers. ( Miladi-Gorji, H; Pourhassanali, N; Zarbakhsh, S, 2021) |
| "This study was designed to examine whether treadmill exercise would attenuate the severity of physical dependence, methadone-induced anxiety, depression and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment (MMT)." | 3.88 | Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment. ( Alizadeh, M; Miladi-Gorji, H; Zahedi-Khorasani, M, 2018) |
| " Factors influencing adherence to buprenorphine during pregnancy have not been identified." | 3.88 | Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence. ( Catlin, D; Coker, JL; Knight, B; Ray-Griffith, S; Stowe, ZN, 2018) |
| "Comprehensive cerebral metabolites involved in morphine dependence have not been well explored." | 3.78 | (1) H-nuclear magnetic resonance-based metabonomic analysis of brain in rhesus monkeys with morphine treatment and withdrawal intervention. ( Bu, Q; Cen, X; Deng, P; Deng, Y; Duan, J; Hu, C; Hu, Z; Li, Y; Shao, X; Yan, G; Zhao, J; Zhao, Y; Zhou, J; Zhu, R, 2012) |
| "To identify maternal and neonatal factors that impact response to methadone therapy for neonatal abstinence syndrome." | 3.77 | Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. ( Akinbi, H; Isemann, B; Meinzen-Derr, J, 2011) |
| "To report the occurrence of bradycardia associated with the use of methadone administered to prevent withdrawal in an infant with physical tolerance following long-term opioid therapy in the pediatric intensive care unit setting." | 3.73 | Bradycardia during methadone therapy in an infant. ( Tobias, JD; Wheeler, AD, 2006) |
| "Five patients presented with acute esotropia within days of heroin withdrawal, and two patients developed exotropia related to heroin or methadone intake." | 3.72 | Heroin and strabismus. ( Landau, K; Sutter, FK, 2003) |
| "To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy." | 3.72 | Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004) |
| "In 61 patients with the ICD-10 diagnosis "heroin dependence" an evaluation of subjective well-being with consideration given to coexisting symptoms prior to and 4 months after initiation of methadone maintenance." | 3.71 | [Subjective wellbeing and somatic markers in methadone substitution. Evaluation of 61 heroin addicts]. ( Ertl, M; Giacomuzzi, SM; Hinterhuber, H; Kemmler, G; Richter, R; Riemer, Y; Rössler, H, 2001) |
| "The volume of feeds, changes in infant body weight, as well as occurrence of adverse clinical effects in infants withdrawing from methadone were studied during the first month of life." | 3.70 | Hyperphagia in neonates withdrawing from methadone. ( Kastner, B; Martinez, A; Taeusch, HW, 1999) |
| " Compared to patients with pre-existing heroin, codeine, or morphine abuse respectively, patients from the methadone maintenance programme had significantly higher (P<0." | 3.70 | Safety, efficacy, and long-term results of a modified version of rapid opiate detoxification under general anaesthesia: a prospective study in methadone, heroin, codeine and morphine addicts. ( Hensel, M; Kox, WJ, 2000) |
| " All nine patients met DSM-III-R criteria for concurrent cocaine and heroin dependence, were neurologically normal, were negative for the human immunodeficiency virus, and had normal clinical brain MRI scans." | 3.69 | Abnormal cerebral metabolism in polydrug abusers during early withdrawal: a 31P MR spectroscopy study. ( Christensen, JD; Cohen, BM; Holman, BL; Kaufman, MJ; Levin, JM; Mendelson, JH; Renshaw, PF, 1996) |
| " Both of the mothers were on methadone maintenance for narcotic dependency prior to the diagnosis of pregnancy." | 3.68 | Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate. ( Hinderliter, SA; Sutton, LR, 1990) |
| "To determine whether sublingual naloxone could precipitate withdrawal in opioid-dependent subjects, naloxone was administered in increasing doses (0-8 mg in four or six sessions conducted over 2 days) to six heroin abusers and three methadone (30 mg/day, p." | 3.68 | Effects of sublingually given naloxone in opioid-dependent human volunteers. ( Bigelow, GE; Liebson, IA; Preston, KL, 1990) |
| "An atypical depression, resembling beta-phenylethylamine (PEA) deficiency states, frequently complicates methadone withdrawal." | 3.67 | Depression during methadone withdrawal: no role for beta-phenylethylamine. ( Chuang, LW; Karoum, F; Kaufmann, CA; Kreek, MJ, 1984) |
| "The authors describe their experience with methadone treatment in pregnancy." | 3.67 | Methadone in pregnancy: clinical-toxicological aspects. ( Chiarotti, M; De Giovanni, N; Falasconi, AM; Offidani, C, 1986) |
| "Female rats were given different doses of methadone for the whole duration of pregnancy." | 3.67 | Fetal addiction to methadone: postnatal abstinence syndrome and development of visual evoked potentials. ( Onofrj, M; Pinto, F; Pola, P; Tempesta, E; Torrioli, MG, 1986) |
| "This article explores the issues raised by methadone maintenance during pregnancy with a focus on intervention techniques for the drug counselor." | 3.67 | When the client is pregnant: information for counselors. ( Williams, A, 1985) |
| "The effects of maternal use of methadone during pregnancy on tests of thyroid function were studied in 14 women and their offspring." | 3.66 | Effects of methadone on thyroid function in mother, fetus, and newborn. ( Chandavasu, O; Dube, SK; Evans, HE; Glass, L; Jhaveri, RC; Khan, F; Rosenfeld, W; Salazar, JD, 1980) |
| " One, 3, 7, 10 and 14 days after the drug was administered rats were injected with naloxone hydrochloride (10 mg/kg) and during the following 4 hours body weights, core temperature and behavioral signs such as diarrhea, writhing, teeth chattering and wet dog shakes were recorded." | 3.66 | Dependence in rats after one injection of heroin-, LAAM- or hydromorphone-zinc tannate. ( Baskerville, JC; Brands, B; Gowdey, CW; Hirst, M, 1979) |
| "Biofeedback was used as a means to relieve stress and anxiety for methadone patients." | 3.66 | Biofeedback application to drug addiction in the University of Colorado drug rehabilitation program. ( Brinkman, DN, 1978) |
| " Heroin abuse declined while methadone usage increased during those years." | 3.65 | The narcotic-dependent mother: fetal and neonatal consequences. ( Albin, S; Eidelman, A; Gartner, LM; Kandall, SR; Lee, KS; Lowinson, J, 1977) |
| "The course of pregnancy and delivery in 28 women under closely supervised methadone maintenance (group 1) was compared with that of 57 women using heroin or methadone under less controlled circumstances (group 2) and with that of 30 women free of mood-altering medications (group 3)." | 3.65 | Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs. ( Adamsons, K; Stimmel, B, 1976) |
| "A pregnant patient in the midtrimester of pregnancy was begun on a methadone detoxification program." | 3.65 | Fetal stress from methadone withdrawal. ( Davis, R; Gumpel, JA; Madden, J; Mejia-Zelaya, A; Zuspan, FP, 1975) |
| " Morphine was detected in significant amounts in maternal and fetal urine regardless of whether the mother was on a methadone program or whether she denied any use of heroin during the last trimester of pregnancy." | 3.65 | A study of factors that influence the severity of neonatal narcotic withdrawal. ( Chavez, CJ; Ostrea, EM; Strauss, ME, 1975) |
| "Drug addiction during pregnancy has been managed in two ways: the detoxification program and the methadone-maintenance treatment program." | 3.65 | Drug addiction in pregnancy and the neonate. ( Ackerman, BD; Blinick, G; Jerez, E; Wallach, RC, 1976) |
| " In this exploratory analysis, we examined the effect of recent cannabis use on opioid use, craving, and withdrawal symptoms, in individuals participating in a trial comparing flexible buprenorphine/naloxone (BUP/NX) take-home dosing model to witnessed ingestion of methadone." | 3.30 | Differential effect of cannabis use on opioid agonist treatment outcomes: Exploratory analyses from the OPTIMA study. ( Bakouni, H; Bastien, G; Brissette, S; Elkrief, L; Hébert, FO; Jutras-Aswad, D; Le Foll, B; Ledjiar, O; Lim, R; Marsan, S; McAnulty, C; Socias, ME, 2023) |
| "Pain, drug cravings, and opioid withdrawal symptoms can interfere with substance use disorder or opioid tapering treatment goals." | 3.11 | Hyperbaric Oxygen Therapy for Pain, Opioid Withdrawal, and Related Symptoms: A Pilot Randomized Controlled Trial. ( Bindler, RJ; Layton, ME; Quock, RM; Stanek, K; Wilson, M, 2022) |
| "Pharmacotherapeutic options for the treatment of opioid withdrawal are limited by abuse potential, adverse effects, and lack of availability of existing drugs." | 3.01 | Efficacy and safety of tramadol in the treatment of opioid withdrawal: A meta-analysis of randomized controlled trials. ( Maiti, R; Mishra, BR; Mohapatra, D; Padhan, M, 2023) |
| "Fifteen men with opioid use disorder on methadone maintenance treatment have been enrolled from an addiction treatment center as an experimental group in this case-controlled study." | 2.90 | Adjuvant laser meridian massage in men with opioid use disorder on methadone maintenance treatment: Protocol for a case-controlled study. ( Hu, WL; Hung, YC; Kuo, CE; Liu, CT; Tsai, MC; Wu, SY; Wu, TC, 2019) |
| "Methadone maintenance treatment (MMT) is an effective way to address opioid use disorder and prevent overdose; however, few jails and prisons in the United States initiate or continue people who are incarcerated on MMT." | 2.87 | A randomized, open label trial of methadone continuation versus forced withdrawal in a combined US prison and jail: Findings at 12 months post-release. ( Brinkley-Rubinstein, L; Dauria, E; Larney, S; Macmadu, A; McKenzie, M; Rich, J; Zaller, N, 2018) |
| "During induction/stabilisation, withdrawal symptoms subsided more slowly for buprenorphine/naloxone than for methadone, and craving was significantly higher in the buprenorphine/naloxone group ( p<0." | 2.84 | Buprenorphine/naloxone versus methadone and lofexidine in community stabilisation and detoxification: A randomised controlled trial of low dose short-term opiate-dependent individuals. ( Coulton, S; Diaper, AM; Law, FD; Melichar, JK; Myles, JS; Nutt, DJ, 2017) |
| "Besides simply managing withdrawal symptoms, clinicians can further improve the care of patients with OUD through initiating maintenance treatment with MOUD, ideally with opioids used in the initial management of withdrawal." | 2.82 | Management of opioid withdrawal and initiation of medications for opioid use disorder in the hospital setting. ( Angermaier, G; Carswell, N; Castaneda, C; Delgado, F, 2022) |
| "Novel buprenorphine dosing strategies have emerged with an aim to transition patients from opioid agonists to buprenorphine without prerequisite opioid withdrawal." | 2.82 | Factors that distinguish opioid withdrawal during induction with buprenorphine microdosing: a configurational analysis. ( D M, S; E J, M; K K, A, 2022) |
| " Serial blood samples were taken for pharmacokinetic analysis." | 2.80 | Effect of steady-state faldaprevir on the pharmacokinetics of steady-state methadone and buprenorphine-naloxone in subjects receiving stable addiction management therapy. ( Adeniji, A; Elgadi, M; Huang, F; Joseph, D; Riesenberg, RR; Schobelock, MJ; Vince, BD; Webster, LR, 2015) |
| " Rilpivirine decreased methadone minimum and maximum plasma concentrations (Cmin ; Cmax ) and area under the plasma concentration-time curve versus methadone alone (least-square mean ratio; 90% confidence interval) by 22% (0." | 2.79 | The effect of rilpivirine on the pharmacokinetics of methadone in HIV-negative volunteers. ( Buelens, A; Crauwels, HM; Hoetelmans, RM; Stevens, M; van Heeswijk, RP; Vandevoorde, A, 2014) |
| "Methadone is a synthetic opioid that binds to the κ-opioid receptor with a low affinity." | 2.79 | The association of genetic polymorphisms in the κ-opioid receptor 1 gene with body weight, alcohol use, and withdrawal symptoms in patients with methadone maintenance. ( Chang, YS; Chen, AC; Chen, CH; Chung, RH; Fang, CP; Ho, IK; Hsiao, CF; Huang, BH; Kuo, HW; Lin, KM; Liu, SC; Liu, YL; Shih, YH; Tsou, HH; Wang, SC; Wu, HY, 2014) |
| " The minimum plasma concentration in the dosing interval (C(min)), the maximum plasma concentration (Cmax), and the area under the plasma concentration-time curve from h 0 (time of administration) to 24 h postdose (AUC(0-24)) for R-methadone were reduced by 31%, 29%, and 29%, respectively, in the presence of telaprevir." | 2.78 | Pharmacokinetic interaction between telaprevir and methadone. ( Boogaerts, G; De Paepe, E; Garg, V; Snoeys, J; van Heeswijk, R; Van Solingen-Ristea, R; Vandevoorde, A; Verboven, P; Vinck, P; Witek, J, 2013) |
| "Dolutegravir (DTG) is an investigational integrase inhibitor for treatment of HIV infection." | 2.78 | Dolutegravir does not affect methadone pharmacokinetics in opioid-dependent, HIV-seronegative subjects. ( Bala, U; Chen, S; Geoffroy, P; Mark, S; Peppercorn, A; Piscitelli, S; Savina, P; Song, I; Wajima, T, 2013) |
| "Gabapentin is a potentially useful drug in alleviating the hyperexcitatory painful states in the control of opiate dependence in acute detoxification and the stabilization phase." | 2.78 | The effects of gabapentin on methadone based addiction treatment: a randomized controlled trial. ( Alavinia, M; Moghadam, MS, 2013) |
| "The methadone was then decreased to once daily and tapered off over the next 10 days." | 2.76 | A trial of methadone tapering schedules in pediatric intensive care unit patients exposed to prolonged sedative infusions. ( Bowens, CD; Breitzka, RL; Sheeran, PW; Thompson, DG; Thompson, JA; Thompson, MT, 2011) |
| "The influence of alcohol use on opioid dependence is a major problem that warrants a search for more effective treatment strategies." | 2.76 | Problem drinking and low-dose naltrexone-assisted opioid detoxification. ( Gorelick, DA; Mannelli, P; Patkar, AA; Peindl, K; Tharwani, HM; Wu, LT, 2011) |
| "The intensity of withdrawal in opiate dependence shows a high inter-individual variability." | 2.74 | Intensity of opiate withdrawal in relation to the 825C>T polymorphism of the G-protein beta 3 subunit gene. ( Augener, S; Bachmann, HS; Bonnet, U; Lieb, B; Scherbaum, N; Siffert, W; Specka, M, 2009) |
| "Methadone has been shown to increase cigarette smoking in a dose-dependent manner, whereas smoking/nicotine has been shown to increase methadone self-administration and reinforcing properties." | 2.74 | Methadone-nicotine interactions in methadone maintenance treatment patients. ( Brands, B; Elkader, AK; Selby, P; Sproule, BA, 2009) |
| "Methadone is an effective therapy for heroin addiction, but the public health benefits are compromised by diversion and injection of prescribed methadone." | 2.74 | The acceptability, safety, and tolerability of methadone/naloxone in a 50:1 ratio. ( Bell, J; Graham, R; Korompay, K; Rizzo, S; Ryan, A; Shearer, J; Sindhusake, D; Somogyi, AA, 2009) |
| "But, number and severity of withdrawal symptoms in methadone+TENS group were significantly lower than methadone group during tenth and fourteenth days." | 2.73 | A randomized effectiveness trial of methadone, TENS and methadone plus TENS in management of opiate withdrawal symptoms. ( Bakhshani, NM; Lashkaripour, K; Sadjadi, SA, 2008) |
| "The aim of this study was to determine, using methadone pharmacokinetic properties, whether methadone dosage adjustments are needed on initiation of treatment with pegIFN alfa-2b for HCV in methadone-maintained HIV-positive patients." | 2.73 | Effects of pegylated interferon alfa-2b on the pharmacokinetic and pharmacodynamic properties of methadone: a prospective, nonrandomized, crossover study in patients coinfected with hepatitis C and HIV receiving methadone maintenance treatment. ( Arnsten, JH; Berk, SI; Du, E; Gourevitch, MN; Litwin, AH; Soloway, I, 2007) |
| "5mg) may be an effective mechanism for safely dosing this medication in persons with higher levels of physical dependence." | 2.73 | Sublingual buprenorphine/naloxone precipitated withdrawal in subjects maintained on 100mg of daily methadone. ( Bigelow, GE; Rosado, J; Strain, EC; Walsh, SL, 2007) |
| "Methadone maintenance treatment clinic." | 2.73 | Melatonin for perceived sleep disturbances associated with benzodiazepine withdrawal among patients in methadone maintenance treatment: a double-blind randomized clinical trial. ( Adelson, M; Bar-Hamburger, R; Hetzroni, T; Peles, E; Schreiber, S, 2007) |
| " The major aims were to compare the efficacy of Bup and Meth in a flexible dosing regimen and to identify possible predictors of outcome." | 2.73 | Retention rate and substance use in methadone and buprenorphine maintenance therapy and predictors of outcome: results from a randomized study. ( Koller, G; Kuefner, H; Soyka, M; Zingg, C, 2008) |
| " Although these specific dosing procedures would not necessarily be used in clinical settings, they provide a procedural template that might be applied safely and effectively with a broader range of treatment-seeking individuals." | 2.72 | Early impact of methadone induction for heroin dependence: differential effects of two dose sequences in a randomized controlled study. ( Greenwald, MK, 2006) |
| " However, it is not known if this is due to changes in bioavailability or if this phenomenon is stereoselective." | 2.72 | Stereoselective quantification of methadone and a d(6)-labeled isotopomer using high performance liquid chromatography-atmospheric pressure chemical ionization mass-spectrometry: application to a pharmacokinetic study in a methadone maintained subject. ( Foster, DJ; Heinkele, G; Morton, EB; Mürdter, TE; Somogyi, AA, 2006) |
| "Severity of opioid dependence, and performance on two successive runs of the Wisconsin Card Sorting Test (WCST), were assessed in 39 right-handed male and female methadone patients who had been randomly assigned to either a recently dosed (n=21) or 24 hr abstinent (n=18) condition." | 2.71 | Neuropsychological correlates of opioid dependence and withdrawal. ( Lyvers, M; Yakimoff, M, 2003) |
| " Fifty-one patients were inducted onto buprenorphine using the same dosing protocol with the first dose of 4 mg buprenorphine." | 2.71 | Cessation of methadone maintenance treatment using buprenorphine: transfer from methadone to buprenorphine and subsequent buprenorphine reductions. ( Bell, J; Breen, CL; Harris, SJ; Hawken, L; Lenné, M; Lintzeris, N; Mattick, RP; Mendoza, E; Ritter, AJ, 2003) |
| "Objective and subjective withdrawal symptoms showed largely identical outcomes and were equally low in the two groups for those who remained in the study." | 2.71 | Rapid detoxification from opioid dependence under general anaesthesia versus standard methadone tapering: abstinence rates and withdrawal distress experiences. ( De Jong, CA; Heinen, N; Koning, JP; Krabbe, PF; Laheij, RJ; van Cauter, RM, 2003) |
| "In conclusion, neither the intensity of withdrawal symptoms nor the intensity of heroin craving constitutes the primary reason for premature termination of detoxification." | 2.71 | [Is premature termination of opiate detoxification due to intensive withdrawal or craving?]. ( Heppekausen, K; Rist, F; Scherbaum, N, 2004) |
| " In comparison to (R)-methadone, plasma nor- and dinor-LAAM concentrations fluctuated little over the dosing interval." | 2.71 | Evaluation of levo-alpha-acetylmethdol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal: a pharmacokinetic and pharmacodynamic analysis. ( Bochner, F; Newcombe, DA; Somogyi, AA; White, JM, 2004) |
| " Withdrawal scores at the time of dosing were higher in the TOP patients (9." | 2.71 | Comparison of tincture of opium and methadone to control opioid withdrawal in a Thai treatment centre. ( Ali, R; Bochner, F; Foster, DJ; Jittiwutikarn, J; Somogyi, AA; White, JM, 2004) |
| "Methadone was first given to all patients within 24h of treatment admission." | 2.71 | Randomized controlled study transitioning opioid-dependent pregnant women from short-acting morphine to buprenorphine or methadone. ( Jasinski, DR; Johnson, RE; Jones, HE; Milio, L, 2005) |
| " The mean area under the methadone concentration curve 0-24 h (AUC(0,24 h)) was also significantly reduced from 12341 (range 3682-34147) to 5309 (range 2430-10349) ng ml(-1) h in the presence of efavirenz, P = 0." | 2.70 | The pharmacokinetics of methadone in HIV-positive patients receiving the non-nucleoside reverse transcriptase inhibitor efavirenz. ( Back, DJ; Barry, MG; Clarke, SM; Gibbons, SE; Mulcahy, FM; Reynolds, HE; Tjia, J, 2001) |
| "Methadone patients had lower baseline MHPG levels." | 2.70 | Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients. ( Charney, DS; Kosten, TR; Krystal, JH; Petrakis, IL; Southwick, SM; Stine, SM, 2002) |
| "Significant differences in levels of withdrawal symptoms were found on days 11, 13-15 and 17-20, symptoms resolving most rapidly in the 5-day lofexidine treatment group, whilst withdrawal responses in the 10-day lofexidine treatment group were intermediate between the 5-day lofexidine and standard methadone treatment conditions." | 2.69 | Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification. ( Bearn, J; Gossop, M; Strang, J, 1998) |
| "Objective and subjective withdrawal symptoms were measured until urine was free of drugs and patients had no withdrawal symptoms." | 2.69 | Opiate detoxification under anesthesia: no apparent benefit but suppression of thyroid hormones and risk of pulmonary and renal failure. ( Hirtl, C; Pfab, R; Zilker, T, 1999) |
| " Comparisons of physiological and subjective measures collected in agonist exposure sessions indicate that LAAM is not less potent than methadone under acute dosing conditions." | 2.69 | Relative potency of levo-alpha-acetylmethadol and methadone in humans under acute dosing conditions. ( Bigelow, GE; Buchhalter, AR; Eissenberg, T; Stitzer, ML; Walsh, SL, 1999) |
| " Subjective symptoms and pharmacodynamic measures were assessed throughout the study period." | 2.69 | Three oral formulations of methadone. A clinical and pharmacodynamic comparison. ( Freeman, K; Gourevitch, MN; Hartel, D; Hecht, J; Lowinson, J; Marion, I; Tenore, P, 1999) |
| "Naloxone treatment, in opioid-addicted patients, induced a marked increase in catecholamine plasma concentrations, metabolism, and cardiovascular stimulation during anesthesia with both propofol and methohexital." | 2.69 | Acute detoxification of opioid-addicted patients with naloxone during propofol or methohexital anesthesia: a comparison of withdrawal symptoms, neuroendocrine, metabolic, and cardiovascular patterns. ( Gastpar, M; Kienbaum, P; Michel, MC; Peters, J; Scherbaum, N; Thürauf, N, 2000) |
| "Trazodone is a non-tricyclic antidepressant drug with specific antagonistic activities at 5-HT(2) and alpha-1 adrenoceptors." | 2.69 | Combined use of trazodone-naltrexone versus clonidine-naltrexone in rapid withdrawal from methadone treatment. A comparative inpatient study. ( Conte, G; De Risio, S; Pozzi, G, 2000) |
| "Withdrawal symptoms were significantly less severe on days 4-7, and 9-13, in the naltrexone/lofexidine combination group." | 2.69 | Naltrexone and lofexidine combination treatment compared with conventional lofexidine treatment for in-patient opiate detoxification. ( Bearn, J; Buntwal, N; Gossop, M; Strang, J, 2000) |
| "A retrospective, inception cohort, nonrandomized control design was employed to evaluate the effects of daily vs twice daily dosing of methadone on opiate/cocaine use, and noncompliance with urine toxicology requests in methadone-maintained pregnant women, n = 45." | 2.68 | Methadone dosing and pregnancy: impact on program compliance. ( DePetrillo, PB; Rice, JM, 1995) |
| "Amantadine was well tolerated." | 2.68 | Amantadine does not reduce cocaine use or craving in cocaine-dependent methadone maintenance patients. ( Handelsman, L; Limpitlaw, L; Paris, P; Schmeidler, J; Stimmel, B; Williams, D, 1995) |
| " Testing consisted of three daily sessions of fixed cocaine dosing (four injections; 0, 16 and 48 mg/70 kg) and three daily sessions of cocaine self-administration with a choice procedure (16, 32 and 48 mg/70 kg vs." | 2.68 | Effects of methadone or buprenorphine maintenance on the subjective and reinforcing effects of intravenous cocaine in humans. ( Fischman, MW; Foltin, RW, 1996) |
| "The lofexidine treatment more severe symptoms from day 3 to 7 and again on day 10 (the last day of treatment), but thereafter both groups showed a similar progressive symptom decline." | 2.68 | Randomised double-blind comparison of lofexidine and methadone in the in-patient treatment of opiate withdrawal. ( Bearn, J; Gossop, M; Strang, J, 1996) |
| "Buprenorphine (BUP) is an alternative to methadone (METH) maintenance." | 2.68 | A protocol to switch high-dose, methadone-maintained subjects to buprenorphine. ( Connerney, I; Fischman, MW; Foltin, RW; Levin, FR, 1997) |
| "Naloxone produced marked opiate withdrawal symptoms." | 2.68 | Buprenorphine and naloxone interactions in methadone maintenance patients. ( Batki, SL; Brown, J; Jones, RT; Mendelson, J; Welm, S, 1997) |
| " The formulation prepared from tablets provides flexible dosing in patients undergoing rapid withdrawal from methadone." | 2.68 | Formulation and stability of naltrexone oral liquid for rapid withdrawal from methadone. ( Fawcett, JP; Morgan, NC; Woods, DJ, 1997) |
| "Clonidine was more effective than lefetamine in suppressing withdrawal in the first 3 days of treatment (day 3: F = 4." | 2.67 | Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine. ( Janiri, L; Mannelli, P; Persico, AM; Serretti, A; Tempesta, E, 1994) |
| "No methadone-treated patient required modification of the therapeutic regimen, whereas eight of eleven placebo-treated patients needed treatment with methadone." | 2.67 | Assessment and management of opioid withdrawal symptoms in buprenorphine-dependent subjects. ( Camí, J; Fernández, T; Ollé, JM; Peri, JM; San, L; Torrens, M, 1992) |
| "Methadone pretreatments may provide a convenient mechanism for the production and examination of long-term mu-opiate receptor physical dependence." | 2.67 | Time course of naloxone-precipitated withdrawal after acute methadone exposure in humans. ( Bigelow, GE; Felch, LJ; June, HL; Stitzer, ML; Wright, C, 1991) |
| "Precipitated withdrawal symptoms were mild and related to dose of buprenorphine." | 2.67 | Treatment of heroin addicts using buprenorphine. ( Kleber, HD; Kosten, TR; Morgan, C, 1991) |
| "Demand for treatments for severe opioid use disorder is increasing worldwide." | 2.66 | Clinical benefits and risks of N-methyl-d-aspartate receptor antagonists to treat severe opioid use disorder: A systematic review. ( Fluyau, D; Pierre, CG; Revadigar, N, 2020) |
| " Physiologic measures and subject- and observer-rated behavioral responses were measured before dosing and for 2 hr after drug administration." | 2.66 | Butorphanol-precipitated withdrawal in opioid-dependent human volunteers. ( Bigelow, GE; Liebson, IA; Preston, KL, 1988) |
| " Although buprenorphine dose was not associated with retention or illicit opioid use, patterns of withdrawal symptoms differed among dosage groups during the 30 day study." | 2.66 | Buprenorphine detoxification from opioid dependence: a pilot study. ( Kleber, HD; Kosten, TR, 1988) |
| "Clonidine appears to be a safe and efficacious outpatient treatment for opiate withdrawal, although the results were less favorable than those obtained in open or inpatient studies." | 2.66 | Clonidine in outpatient detoxification from methadone maintenance. ( Charney, D; Gaspari, J; Hogan, I; Kleber, HD; Kosten, T; O'Connor, C; Riordan, CE; Rounsaville, B, 1985) |
| " Patients randomly assigned to the gradual group (group G) began 4-mg/wk reduction the Monday of week 9 and reached zero dosage (placebo) the Monday of week 23; patients in the abrupt group (group A) continued to receive 50, 50, and 65 mg until the Monday of week 23, when their dosage was dropped to zero (placebo)." | 2.65 | Methadyl acetate (LAAM) in the treatment of heroin addicts. II. Double-blind comparison of gradual and abrupt detoxification. ( Goldstein, A; Inturrisi, CE; Judson, BA, 1983) |
| "Lofexidine might prove to be a safer and more effective nonopiate treatment for opiate withdrawal, especially for ambulatory outpatients; controlled studies are required to confirm this possibility." | 2.65 | Opiate withdrawal using lofexidine, a clonidine analogue with fewer side effects. ( Geyer, G; Resnick, RB; Washton, AM, 1983) |
| " Outcome measures included retention to the end of the dosing schedule, use of illicit drugs during treatment, subjective discomfort, satisfaction, staff ratings of global progress, and durability of change at a three-month follow-up." | 2.65 | Withdrawal from heroin in three or six weeks. Comparison of methadyl acetate and methadone. ( Hargreaves, WA; Sorensen, JL; Weinberg, JA, 1982) |
| " Under controlled inpatient conditions established to assess dosage guidelines and to examine specific signs and symptoms of withdrawal, ten (91%) of 11 patients were able to withdraw completely from methadone therapy by the end of a six-day period." | 2.65 | Clonidine and naltrexone. A safe, effective, and rapid treatment of abrupt withdrawal from methadone therapy. ( Braverman, P; Charney, DS; Heninger, GR; Kleber, HD; Murburg, M; Redmond, DE; Riordan, CE; Sternberg, DE, 1982) |
| "Clonidine hydrochloride was found to be effective in the treatment of methadone hydrochloride withdrawal." | 2.65 | The clinical use of clonidine in abrupt withdrawal from methadone. Effects on blood pressure and specific signs and symptoms. ( Charney, DS; Heninger, GR; Kleber, HD; Redmond, DE; Sternberg, DE, 1981) |
| "Buprenorphine was evaluated for its abuse potential and utility in treating narcotic addiction." | 2.64 | Human pharmacology and abuse potential of the analgesic buprenorphine: a potential agent for treating narcotic addiction. ( Griffith, JD; Jasinski, DR; Pevnick, JS, 1978) |
| " The initial dosage was 24 mg/day for methadone hydrochloride and 800 mg/day for propoxyphene napsylate." | 2.64 | Heroin detoxification. A comparison of propoxyphene and methadone. ( Bleich, RN; Casas, SK; Russell, BA; Tennant, FS, 1975) |
| "Methadone chlorhydrate has been administred to opiate addicts either for a short period with a decreasing dosage as a withdrawal cure, or for longterm treatments as a basis of a maintenance program." | 2.64 | [A French experience with methadone]. ( Cuche, H; Deniker, P; Loo, H; Zarifian, E, 1975) |
| "Memantine was well tolerated with similar rates of adverse effects between treatment groups." | 2.61 | Adjunctive memantine for opioid use disorder treatment: A systematic review. ( Brown, JN; Elias, AM; Pepin, MJ, 2019) |
| "Buprenorphine was superior to clonidine in controlling severe withdrawal symptoms in an outpatient setting (RR 0." | 2.58 | Pharmacological therapies for management of opium withdrawal. ( Amato, L; Amin-Esmaeili, M; Gholami, J; Hoseinie, L; Rahimi-Movaghar, A; Yousefi-Nooraie, R, 2018) |
| ": Medication-assisted treatment for opioid use disorder (OUD), which incorporates methadone, buprenorphine, or naltrexone, has been shown to reduce all-cause mortality rates in patients with this disease-and the numbers of patients receiving such treatment is substantial." | 2.58 | CE: Acute Pain Management for People with Opioid Use Disorder. ( Broglio, K; Matzo, M, 2018) |
| "Our study of the available oral treatments for opioid dependence has revealed that no current treatment can actually claim to be fully effective." | 2.55 | Opioid Addiction: Social Problems Associated and Implications of Both Current and Possible Future Treatments, including Polymeric Therapeutics for Giving Up the Habit of Opioid Consumption. ( Benéitez, MC; Gil-Alegre, ME, 2017) |
| "Methadone is a synthetic opioid analgesic with potential advantages over other commonly used opioids." | 2.53 | Methadone analgesia in the critically ill. ( Elefritz, JL; Lyaker, MR; Murphy, CV; Papadimos, TJ, 2016) |
| "Substance use disorders are common in primary care settings, but detection, assessment, and management are seldom undertaken." | 2.50 | Addiction disorders. ( Duncan, MH; Merrill, JO, 2014) |
| "Methadone treatment has been 'programmatic', with a one-size-fits-all approach that in part reflects the perceived need to impose discipline on deviant individuals." | 2.50 | Pharmacological maintenance treatments of opiate addiction. ( Bell, J, 2014) |
| "Constant refinement of opioid dependence (OD) therapies is a condition to promote treatment access and delivery." | 2.48 | Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives. ( Bhatia, KS; Lee, T; Mannelli, P; Peindl, KS; Wu, LT, 2012) |
| " Different approaches, such as weight-based and formula-based methods, have been used to determine the initial methadone dosing regimen." | 2.48 | Selection of the initial methadone regimen for the management of iatrogenic opioid abstinence syndrome in critically ill children. ( Boyles, KA; Johnson, PN; Miller, JL, 2012) |
| "Opioid dependence is a significant public health problem associated with high risk for relapse if treatment is not ongoing." | 2.48 | Opioid detoxification and naltrexone induction strategies: recommendations for clinical practice. ( Bisaga, A; Kosten, T; Nunes, EV; O'Connor, PG; Sigmon, SC; Woody, G, 2012) |
| "Treatment for opiate addiction requires long-term management." | 2.48 | Maintenance medication for opiate addiction: the foundation of recovery. ( Bart, G, 2012) |
| "Opioid dependence is becoming a more common problem in the United States that gives rise to many negative health and social consequences for both individuals and society as a whole." | 2.47 | Opioid dependence. ( Benich, JJ, 2011) |
| "Pharmacological approaches incorporate the continuation of usual medications (or equivalent), short-term use of sometimes much higher than average doses of additional opioid, and prescription of non-opioid and adjuvant drugs, aiming to improve pain relief and attenuate opioid tolerance and/or opioid-induced hyperalgesia." | 2.47 | Acute pain management in opioid-tolerant patients: a growing challenge. ( Huxtable, CA; MacIntyre, PE; Roberts, LJ; Somogyi, AA, 2011) |
| "Pharmacotherapy of opioid addiction alone is usually insufficient, and a complete treatment should also include effective psychosocial support or other interventions." | 2.46 | The pharmacological treatment of opioid addiction--a clinical perspective. ( Bramness, J; Gossop, M; Lobmaier, P; Waal, H, 2010) |
| "Methadone has been the standard medication for the management of heroin craving." | 2.46 | Heroin anticraving medications: a systematic review. ( Amar, R; Casarella, J; Drexler, K; Fareed, A; Vayalapalli, S, 2010) |
| "This review extends a prior meta-analysis of acupuncture's utility for treating opioid detoxification, addressing the efficacy of acupuncture when combined with allopathic therapies." | 2.45 | A meta-analysis of acupuncture combined with opioid receptor agonists for treatment of opiate-withdrawal symptoms. ( Bao, YP; Epstein, DH; Liu, TT; Lu, L; Shi, J, 2009) |
| "Methadone is a long-acting synthetic opioid with high affinity for various opioid receptors, especially for m-opioid receptors." | 2.45 | [Methadone treatment and its dangers]. ( Jodziūniene, L; Lazauskas, R; Reingardiene, D, 2009) |
| "The development of effective treatments for opioid dependence is of great importance given the devastating consequences of the disease." | 2.45 | Opioid dependence treatment: options in pharmacotherapy. ( Dodrill, CL; Kosten, TR; Stotts, AL, 2009) |
| "While opioid dependence has more treatment agents available than other abused drugs, none are curative." | 2.44 | Pharmacologic treatments for opioid dependence: detoxification and maintenance options. ( Kleber, HD, 2007) |
| "Methadone maintenance treatment (MMT) has not been officially approved by the Chinese government for widespread implementation, but some pilot studies are currently underway." | 2.43 | Opiate addiction in China: current situation and treatments. ( Cubells, JF; Tang, YL; Zhao, C; Zhao, D, 2006) |
| "Opioid dependence is a chronic and relapsing medical disorder with a well-established neurobiological basis." | 2.43 | Opioid dependence: rationale for and efficacy of existing and new treatments. ( Fiellin, DA; Friedland, GH; Gourevitch, MN, 2006) |
| "Buprenorphine has been studied extensively since 1978 when it was initially proposed as an alternative to methadone for treatment of opioid dependence." | 2.42 | Clinical efficacy of buprenorphine: comparisons to methadone and placebo. ( Ling, W; Wesson, DR, 2003) |
| "Cardiac arrhythmias have been reported with methadone and levomethadyl, but not with buprenorphine." | 2.42 | Treating opioid dependence. Growing implications for primary care. ( Krantz, MJ; Mehler, PS, 2004) |
| "The present essay on drug addiction deals, under the escort of empirical knowledges emanating from medico-legal toxicology, mainly with the behavioural, neurobiological, forensic and pharmacotherapeutical aspects of drug seeking and taking behaviour." | 2.40 | [Drug addiction--origin, development and pharmacological intervention]. ( Pasi, A; Qu, B, 1997) |
| "The scale of drug dependence has grown dramatically in the past quarter-century." | 2.40 | WHO Expert Committee on Drug Dependence. Thirtieth report. ( , 1998) |
| "This paper describes the mechanisms of opiate dependence and opiate withdrawal and reviews the available instruments for the measurement of withdrawal." | 2.39 | Opiate withdrawal. ( Farrell, M, 1994) |
| "The acquired immunodeficiency syndrome (AIDS) has recently emerged as a serious medical complication of parenteral substance abuse." | 2.37 | Major medical problems and detoxification treatment of parenteral drug-abusing alcoholics. ( Novick, DM, 1984) |
| "Clonidine is a central alpha adrenergic agonist which can be used to treat the opiate withdrawal syndrome." | 2.37 | Clonidine and the treatment of the opiate withdrawal syndrome. ( Gossop, M, 1988) |
| " Narcotics are used for the euphoria they provide; however, chronic use results in physiological and psychological changes." | 2.37 | Narcotic withdrawal in the emergency department. ( Freitas, PM, 1985) |
| " The dosing of various drugs currently in use is also discussed." | 2.37 | The neonatal narcotic abstinence syndrome: a brief review. ( Calabrese, JR; Gulledge, AD, 1985) |
| "A cross-sectional, descriptive study was conducted using the daily methadone dosing records from shelters in Tshwane between March 2020 and September 2020." | 1.91 | Methadone use for acute opioid withdrawal in Tshwane shelters during the COVID-19 lockdown. ( Bhoora, U; Janse van Rensburg, M; Siemens, JA, 2023) |
| "The chapters on opioid dependence in the 26 editions of Cecil Textbook of Medicine published from 1927 through 2020." | 1.72 | Pharmacological Management of Heroin Withdrawal Syndrome: A Century of Expert Opinions in Cecil Textbook of Medicine. ( Manu, P; Rogozea, LM; Shulman, M, 2022) |
| "Methadone was administered during 150 episodes of care for 142 unique patients, the majority of whom were male (73%), white (67%), and used fentanyl (85%)." | 1.72 | Bridge clinic implementation of "72-hour rule" methadone for opioid withdrawal management: Impact on opioid treatment program linkage and retention in care. ( Christine, PJ; Evans, J; Farrell, NM; Kehoe, J; Kim, TW; Laks, J; Taylor, JL; Walley, AY; Weinstein, ZM; White, CS, 2022) |
| "Opioid withdrawal symptoms were experienced by 54 participants (93%) whilst taking tramadol." | 1.72 | Managing acute opioid withdrawal with tramadol during COVID-19 lockdown in a peri-urban setting. ( Bhoora, U; Gloeck, NR; Scheibe, A, 2022) |
| "Methadone is frequently used to prevent withdrawal symptoms secondary to intended therapeutic opiate exposure." | 1.62 | Iatrogenic Opiate Withdrawal in Pediatric Patients: Implementation of a Standardized Methadone Weaning Protocol and Withdrawal Assessment Tool. ( Izquierdo, M; Lavandosky, G; Rodriguez, JC; Stevens, JS; Walters, RA, 2021) |
| " Currently, the morphine dosing strategies are empiric, not optimal and associated with longer hospital stay." | 1.62 | Model-Based Approach to Improve Clinical Outcomes in Neonates With Opioid Withdrawal Syndrome Using Real-World Data. ( Aduroja, O; Biggs, JM; El-Metwally, D; Gopalakrishnan, M; Wijekoon, N, 2021) |
| "Methadone maintenance treatment (MMT) is effective in decreasing opioid use or facilitating abstinence." | 1.62 | Impulsivity and craving in subjects with opioid use disorder on methadone maintenance treatment. ( Du, J; Jiang, H; Li, J; Mandali, A; Ren, Q; Sun, B; Voon, V; Weidacker, K; Whiteford, S; Zhang, C; Zhang, Y; Zhou, H; Zhou, Z, 2021) |
| "Buprenorphine is a partial opioid agonist commonly used to treat opioid dependence." | 1.62 | Managing opioid withdrawal precipitated by buprenorphine with buprenorphine. ( Hayes, V; Lintzeris, N; Oakley, B; Wilson, H, 2021) |
| "Buprenorphine/naloxone has a lower abuse potential than buprenorphine and should therefore be prioritized as the prescribed drug." | 1.51 | Non-prescribed use of methadone and buprenorphine prior to opioid substitution treatment: lifetime prevalence, motives, and drug sources among people with opioid dependence in five Swedish cities. ( Johnson, B; Richert, T, 2019) |
| "The buprenorphine dose was further increased based on clinical judgment." | 1.51 | Transitioning Hospitalized Patients with Opioid Use Disorder from Methadone to Buprenorphine without a Period of Opioid Abstinence Using a Microdosing Protocol. ( Calcaterra, SL; Smith, C; Terasaki, D, 2019) |
| "Unfortunately, treatment of opioid dependence is difficult, particularly because of codependence - for example, on alcohol or other drugs of abuse." | 1.48 | Disulfiram attenuates morphine or methadone withdrawal syndrome in mice. ( Bujalska-Zadrożny, M; de Cordé, A; Filip, M; Kleczkowska, P; Krząścik, P; Wolińska, R, 2018) |
| "Seventy-seven patients with heroin addiction were enrolled." | 1.48 | The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users. ( Chen, KC; Chen, PS; Chen, WT; Lee, IH; Lee, LT; Lee, SY; Lin, SH; Lu, RB; Tsai, HC; Yang, YK, 2018) |
| " Here, we examined whether moderate doses of methadone carry any benefits over chronic use of equianalgesic morphine, the prototypical opioid." | 1.38 | Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice. ( Enquist, J; Ferwerda, M; Milan-Lobo, L; Whistler, JL, 2012) |
| " Clinically significant MDIs included withdrawal symptoms, which were found among MMTP patients co-administered with buprenorphine or tramadol; severe QTc prolongation effect, which might be associated with use of haloperidol or droperidol; and additive CNS and respiratory depression, which could result from use of methadone in combination with chlorpromazine or thioridazine." | 1.38 | Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan. ( Lee, HY; Li, JH; Tang, HP; Wu, JS; Wu, LT; Yen, CF, 2012) |
| "Buprenorphine as maintenance treatment of opioid dependence during pregnancy has promise and may offer some benefits, but more research is needed, especially regarding induction of actively addicted women during pregnancy." | 1.38 | Treatment of opioid dependence in the setting of pregnancy. ( Martin, PR; Young, JL, 2012) |
| "366 methadone maintenance treatment patients in Taiwan were recruited and genotyped." | 1.38 | UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients. ( Chen, ACh; Chen, CH; Chen, YT; Fang, CP; Ho, IK; Hsiao, CF; Hsu, YT; Huang, CL; Kuo, HW; Lin, L; Liu, CT; Liu, ML; Liu, SC; Liu, YL; Shih, YH; Su, LW; Tan, HK; Tian, JN; Tsou, HH; Wu, CS; Yang, YH; Yang, YT, 2012) |
| "The aims of the present study were to characterize the relationship between plasma racemic methadone and its enantiomers' concentrations with respect to their pharmacodynamic effects and to investigate the influence of potential covariates on the pharmacodynamic parameters in patients on methadone maintenance treatment (MMT)." | 1.38 | Pharmacokinetic-pharmacodynamic modeling of mood and withdrawal symptoms in relation to plasma concentrations of methadone in patients undergoing methadone maintenance treatment. ( Iqbal, MZ; Lagundoye, O; Lennard, MS; Rostami-Hodjegan, A; Seivewright, N; Shiran, MR; Tucker, GT, 2012) |
| "Patterns of symptom reports may have clinical implications for maternal and fetal health during pregnancy for OM women including optimization of opioid dosing regimens, education regarding maternal nutritional intake and preventing postnatal depression, thereby ensuring maternal health and fetal development during pregnancy and enhancing mother-infant bonding and healthy child development postnatally." | 1.38 | Patterns of symptom reporting during pregnancy comparing opioid maintained and control women. ( Fisk, A; Gordon, AL; Lopatko, OV; Pearson, V; Stacey, H; White, JM; Woods, A, 2012) |
| "Methadone dose was titrated daily, and plasma concentrations were measured." | 1.37 | Usefulness of methadone plasma concentration measurement in patients receiving nevirapine or efavirenz. ( Besson, J; Cavassini, M; Eap, CB; Favrat, B; Monnat, M; Pelet, A, 2011) |
| "Further analyses on specific withdrawal symptoms in COWS showed that the genetic variants in rs4646440 are significantly associated with heart rate (allele type p = 0." | 1.37 | Genetic polymorphisms in CYP3A4 are associated with withdrawal symptoms and adverse reactions in methadone maintenance patients. ( Chen, ACh; Chen, CH; Chou, SY; Fang, KC; Fang, YC; Ho, IK; Hsiao, CF; Hsu, YT; Huang, CL; Lin, KM; Lin, YF; Liu, ML; Liu, SC; Liu, YL; Su, LW; Tian, JN; Tsou, HH; Wang, SC; Yu, CJ, 2011) |
| "We describe the first case of stress cardiomyopathy secondary to a drug-drug interaction." | 1.36 | First case of stress cardiomyopathy as a result of methadone withdrawal secondary to drug-drug interaction. ( Lemesle, F; Nicola, W; Pierre Jonville-Béra, A, 2010) |
| "Methadone patients were more likely to report feeling uncomfortable the first few days, having side/withdrawal effects during treatment, and being concerned about continued dependency on medication after release." | 1.36 | Heroin-dependent inmates' experiences with buprenorphine or methadone maintenance. ( Awgu, E; Magura, S; Rosenblum, A, 2010) |
| " Seventeen methadone patients (7 depressed and 10 not depressed) had pharmacokinetic and pharmacodynamic assessments (opioid withdrawal, drug effects, and mood) over one 24-hour dosing interval." | 1.35 | Major depressive disorder and patient satisfaction in relation to methadone pharmacokinetics and pharmacodynamics in stabilized methadone maintenance patients. ( Brands, B; Dunn, E; Elkader, AK; Selby, P; Sproule, BA, 2009) |
| "Methadone is a proven first-line treatment in opioid dependence but few studies have addressed the efficacy of different isoforms of methadone or the transfer from one form to the other." | 1.35 | Feasability and safety of transfer from racemic methadone to (R)-methadone in primary care: clinical results from an open study. ( Soyka, M; Zingg, C, 2009) |
| " Dosage for methadone and gender may be the risk factors of craving change." | 1.35 | [Change and influence factors of craving for patients after 6 month methadone maintenance treatment]. ( Chen, M; Li, X; Ou, Q; Sun, Z; Tan, H; Zhang, H, 2009) |
| "This case report introduces methadone withdrawal symptoms experienced by a heroin addict who used MRT for a period of four months." | 1.35 | [A case report on methadone withdrawal syndrome]. ( Chuang, P, 2009) |
| " This can be achieved by converting the regular dosage into the equivalent in diazepam and then reducing this dosage by a maximum of 25% a week." | 1.35 | [Guideline 'Medicinal care for drug addicts in penal institutions']. ( Arends, MT; de Haan, HA; Klazinga, NS; van Everdingen, JJ; Westra, M, 2009) |
| "Methadone was used (71." | 1.35 | Prescription opioid use, misuse, and diversion among street drug users in New York City. ( Davis, WR; Johnson, BD, 2008) |
| " Nonetheless, the finding of a dose-response effect supports one of the basic principles of clinical practice during detoxification, namely the matching of the medication withdrawal schedule to the pre-admission opiate dose." | 1.35 | Influence of the dose on the severity of opiate withdrawal symptoms during methadone detoxification. ( Bearn, J; de Wet, C; Glasper, A; Gossop, M; Reed, L, 2008) |
| "Opioid dependence is a complex medical condition affecting neurocognitive and physical functioning." | 1.35 | Ethical and human rights imperatives to ensure medication-assisted treatment for opioid dependence in prisons and pre-trial detention. ( Bruce, RD; Schleifer, RA, 2008) |
| "The first phase of withdrawal symptoms was attributed to the antagonistic effect of naltrexone, which possibly also improved under the weakening of naltrexone." | 1.34 | Naltrexone-assisted rapid methadone discontinuation: a pilot study. ( Besson, J; Camarasa, X; Khazaal, Y; Zullino, DF, 2007) |
| "The SOWS measures withdrawal symptoms at the time of assessment." | 1.34 | Psychometric evaluation of the Dutch version of the Subjective Opiate Withdrawal Scale (SOWS). ( De Jong, CA; Dijkstra, BA; Krabbe, PF; Riezebos, TG; van der Staak, CP, 2007) |
| "Self-medication for withdrawal symptoms is one plausible hypothesis." | 1.34 | Risk factors for methadone outside treatment programs: implications for HIV treatment among injection drug users. ( Galai, N; Gern, R; Kirk, GD; Mehta, SH; O'Driscoll, P; Ompad, DC; Vlahov, D, 2007) |
| "Menopause is a natural process that occurs in women's lives as part of normal aging." | 1.34 | Exploring the prevalence of menopause symptoms in midlife women in methadone maintenance treatment. ( Tuchman, E, 2007) |
| " Blood samples and pharmacodynamic data were collected 10-12 times over a 24-h inter-dosing interval." | 1.33 | Within- and between- subject variability in methadone pharmacokinetics and pharmacodynamics in methadone maintenance subjects. ( Bochner, F; Foster, DJ; Hanna, J; Salter, A; Somogyi, AA; White, JM, 2005) |
| " The reason for the large range in dosage may be multifactorial." | 1.33 | Free and bound enantiomers of methadone and its metabolite, EDDP in methadone maintenance treatment: relationship to dosage? ( Eichhorst, JC; Etter, ML; Fern, B; George, S; Graybiel, K; Kapur, B; Lehotay, DC; Selby, P; Wildenboer, W, 2005) |
| " Equally important perioperative treatment principles are stabilization of physical dependence by substitution with methadone (for heroin addicts) or benzodiazepines/clonidine (for alcohol, sedatives and hypnotics addiction), avoidance of stress and craving, thorough intraoperative and postoperative stress relief by using regional techniques or systematically higher than normal dosages of anesthetics and opioids, strict avoidance of inadequate dosage of analgetics, postoperative optimization of regional or systemic analgesia by non-opioids and coanalgetics and consideration of the complex physical and psychological characteristics and comorbidities." | 1.33 | [Anesthesia and analgesia in addicts: basis for establishing a standard operating procedure]. ( Heid, F; Jage, J, 2006) |
| " The pronounced and variable fluctuations in methadone disposition evident in these patients highlight the need for an individualized approach to patient dosing and monitoring." | 1.33 | Fluctuations in (R,S)-methadone pharmacokinetics and response among long-term methadone maintenance patients. ( Dyer, KR; Mitchell, TB; Newcombe, D; Somogyi, AA; White, JM, 2006) |
| " This retrospective chart review provides an exploratory examination of newborns treated with either methadone or paregoric for opioid withdrawal and outlines dosage ranges and intervals, side effects, and clinical outcomes of the two regimens." | 1.33 | A chart review comparing paregoric to methadone in the treatment of neonatal opioid withdrawal. ( Wunsch, MJ, 2006) |
| "No miscarriages were observed in the second trimester (n = 54; incidence rate ratio = 0 compared to population norms (95% CI = 0-3." | 1.32 | Is opiate detoxification unsafe in pregnancy? ( Bearn, J; Luty, J; Nikolaou, V, 2003) |
| "Lopinavir is a potent inducer of methadone metabolism, and treatment with L/R requires clinical monitoring and increased methadone doses in some patients, whereas ritonavir has no significant effect on methadone metabolism." | 1.32 | The protease inhibitor lopinavir-ritonavir may produce opiate withdrawal in methadone-maintained patients. ( Friedland, G; Jatlow, P; McCance-Katz, EF; Rainey, PM, 2003) |
| "Comorbid psychiatric disorders did not appear to influence methadone effectiveness, but psychopharmacological treatment associated with methadone was associated with a lower rate of urine samples positive for drug use." | 1.32 | Long-term methadone maintenance effectiveness: psychosocial and pharmacological variables. ( Ferri, M; Gerra, G; Polidori, E; Santoro, G; Sternieri, E; Zaimovic, A, 2003) |
| " With time the dosing often increases because of tolerance." | 1.32 | Methadone dosage for prevention of opioid withdrawal in children. ( Cimino, M; Fletcher, JE; Heard, AM; Heard, CM; Kielma, D; Siddappa, R, 2003) |
| "Methadone was tapered and discontinued prior to ROD and Naltrexone was administered in increasing daily doses." | 1.32 | Unexpected delirium during Rapid Opioid Detoxification (ROD). ( Golden, SA; Sakhrani, DL, 2004) |
| "This hyperalgesia is evident in people with a history of heroin use and is not modified by methadone or buprenorphine treatment but is reduced by long-term abstinence from opioids." | 1.32 | Pleasure into pain: the consequences of long-term opioid use. ( White, JM, 2004) |
| "Methadone dosage was also correlated with both duration of neonatal hospitalization and neonatal abstinence score (r(s) =." | 1.31 | Relationship between maternal methadone dosage and neonatal withdrawal. ( Dashe, JS; Jackson, GL; Olscher, DA; Sheffield, JS; Todd, SJ; Wendel, GD, 2002) |
| "Tramadol hydrochloride is a centrally acting analgesic with a partial affinity for the opiate receptor (mu), having an analgesic potency estimated to be one tenth that of morphine." | 1.31 | Methadone detoxification of tramadol dependence. ( DeGuiseppe, B; Leo, RJ; Narendran, R, 2000) |
| "The methadone group was slower to process all sentences compared with family members." | 1.31 | The processing of automatic thoughts of drug use and craving in opiate-dependent individuals. ( Feldtkeller, BT; Law, F; Myles, J; Nutt, DJ; Weinstein, AM, 2000) |
| "Peak fentanyl infusion rate was 5." | 1.31 | Enteral methadone to expedite fentanyl discontinuation and prevent opioid abstinence syndrome in the PICU. ( Cash, J; Lugo, RA; MacLaren, R; Pribble, CG; Vernon, DD, 2001) |
| "Opioid agonist effects and opioid withdrawal symptoms were assessed prior to heroin challenge." | 1.31 | High-dose methadone produces superior opioid blockade and comparable withdrawal suppression to lower doses in opioid-dependent humans. ( Bigelow, GE; Donny, EC; Eissenberg, T; Stitzer, ML; Walsh, SL, 2002) |
| "Most patients do not recognise their withdrawal symptoms, and often the symptoms are mistaken simply as pain." | 1.31 | [Opioid treatment of pain in angina pectoris]. ( Eriksen, J; Hermann, CK, 2002) |
| "Psychological and physiological withdrawal symptoms and some positive factors were studied in 10 methadone maintenance treatment patients during methadone dose reduction." | 1.30 | Patient perceptions of psychological and physiological withdrawal symptoms and positive factors associated with gradual withdrawal from methadone maintenance treatment: a prospective study. ( Borg, S; Eklund, C; Hiltunen, AJ; Melin, L, 1997) |
| "Methadone exposed pups were more active and vocalized more when injected with naltrexone than with saline." | 1.30 | Neonatal withdrawal following pre- and postnatal exposure to methadone in the rat. ( Barr, GA; Hamowy, AS; Hutchings, DE; Liu, PY; Wang, S; Zmitrovich, A, 1998) |
| "Women with mild withdrawal symptoms were given clonidine initially, and methadone was substituted if symptoms persisted." | 1.30 | Opioid detoxification in pregnancy. ( Dashe, JS; Jackson, GL; Olscher, DA; Wendel, GD; Zane, EH, 1998) |
| "Withdrawal symptoms were still present 24 h after detoxification and 80% of the patients relapsed during a 6-month follow-up." | 1.30 | Ultra-rapid opiate detoxification using deep sedation with oral midazolam: short and long-term results. ( Bertschy, G; Cucchia, AT; Ferrero, F; Monnat, M; Spagnoli, J, 1998) |
| " The estimates of pharmacokinetic parameters based on unbound plasma concentrations did not differ between groups, with the sole exception of the unbound apparent volume of distribution." | 1.30 | Altered plasma and brain disposition and pharmacodynamics of methadone in abstinent rats. ( Calvo, R; Garrido, MJ; Trocóniz, IF; Valle, M, 1999) |
| "Methadone has two roles in human immunodeficiency viral infection: pain management and treatment of opioid abuse." | 1.30 | Methadone withdrawal when starting an antiretroviral regimen including nevirapine. ( Heelon, MW; Meade, LB, 1999) |
| "To determine plasma racemic methadone concentration-effect relationships for subjective and objective responses and whether pharmacokinetic and/or pharmacodynamic factors influence withdrawal severity." | 1.30 | Steady-state pharmacokinetics and pharmacodynamics in methadone maintenance patients: comparison of those who do and do not experience withdrawal and concentration-effect relationships. ( Bochner, F; Dyer, KR; Foster, DJ; Menelaou, A; Somogyi, AA; White, JM, 1999) |
| "Treatment with propofol is effective in the case of a patient with a serious withdrawal syndrome secondary to naltrexone overdose during methadone therapy." | 1.30 | Emergency therapeutical approach simulating ultrarapid opioid detoxification in methadone withdrawal precipitated by erroneous administration of naltrexone. ( Barelli, A; De Giacomo, M; Gaspari, R; Mannelli, P; Stefanelli, A, 1999) |
| "Methadone has been effectively used in the treatment of opiate dependence." | 1.30 | A therapeutic use of the methadone fluvoxamine drug interaction. ( DeMaria, PA; Serota, RD, 1999) |
| "1." | 1.29 | Methadone anonymous: a 12-step program. Reducing the stigma of methadone use. ( McGonagle, D, 1994) |
| "Methadone is a typical mu-opioid receptor agonist that is widely used for maintenance and detoxification treatment of opiate-dependent patients." | 1.29 | Methadone withdrawal psychosis. ( Galynker, II; Levinson, I; Rosenthal, RN, 1995) |
| "Buprenorphine is an opioid partial agonist being developed for possible use in the treatment of opioid dependence." | 1.29 | Buprenorphine effects in methadone-maintained volunteers: effects at two hours after methadone. ( Bigelow, GE; Liebson, IA; Preston, KL; Strain, EC, 1995) |
| " A good dose-response relationship was found between the 100% suppressive withdrawal sign doses of DHE and the degree of withdrawal sign in heroin addicts." | 1.29 | [Clinical assessment of physical dependence potential of dihydroetorphine hydrochloride (DHE)]. ( Cai, ZJ; Ge, Y; Li, M; Sun, WL, 1994) |
| " The switch to oral agents must take into consideration the differences in potency, half-life, and oral bioavailability between the agents." | 1.29 | Outpatient therapy of iatrogenic drug dependency following prolonged sedation in the pediatric intensive care unit. ( Deshpande, JK; Gregory, DF; Tobias, JD, 1994) |
| "Methadone treatment for opioid dependence needs to be promoted and liberalized, especially because the oral route of administration eliminates the risks accompanying drug injection." | 1.29 | Inadequate treatment of opioid dependence due to society's attitudes and beliefs. ( Blansfield, HN, 1996) |
| "3." | 1.29 | Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism. ( Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Ruiz, F, 1996) |
| " Three scoring systems to quantify dose-response relationships for withdrawal are described: (1) using the mean number of withdrawal behaviors per animal within each treatment group; (2) using the sum of the percentage of animals within a treatment group displaying each of the withdrawal behaviors; and (3) a modification of these, to further isolate the naloxone-induced component of the withdrawal score, that is, subtraction of data obtained from saline-challenged animals from those of naloxone-challenged rats." | 1.29 | The induction and quantitation of methadone dependence in the rat. ( Hope, W; Pierce, TL; Raper, C, 1996) |
| "Buprenorphine (BUP) is a partial opioid agonist whose effects on BE levels were examined in six former heroin addicts and 14 methadone-maintained patients before and after being switched to sublingual BUP 2 mg daily for 1 month." | 1.28 | Beta endorphin levels during heroin, methadone, buprenorphine, and naloxone challenges: preliminary findings. ( Kosten, TR; Kreek, MJ; Morgan, C, 1992) |
| "Clonidine has been used to assist opiate detoxification in the past 10 years." | 1.28 | Two cases of clonidine abuse/dependence in methadone-maintained patients. ( Lauzon, P, 1992) |
| "4 mg/ml for morphine and methadone, respectively, were achieved using an ascending dosage schedule." | 1.28 | Morphine and methadone dependence in the rat: withdrawal and brain met-enkephalin levels. ( Olley, JE; Pierce, TL; Tiong, GK, 1992) |
| "Clonidine doses used were lower than in similar studies and all patients were alert and mobile throughout withdrawal." | 1.28 | Clonidine versus long- and short-term methadone-aided withdrawal from opiates. An uncontrolled comparison. ( Bradley, B; Gossop, M; Griffiths, P; Kasvikis, Y; Marks, I, 1990) |
| "The metyrapone test was administered to 15 former heroin addicts: 10 (8 male, 2 female) in steady-state methadone maintenance therapy (30 to 90 mg/d) and 5 (3 male, 2 female) in the final phase of a slow methadone dose reduction procedure (0 to 10 mg/d)." | 1.28 | Metyrapone-induced withdrawal symptoms. ( Hartman, N; Kennedy, JA; Khuri, E; Kreek, MJ; Sbriglio, R, 1990) |
| "Patients reported mild opiate withdrawal symptoms after initiation of CBZ treatment." | 1.28 | Carbamazepine treatment of cocaine dependence in methadone maintenance patients with dual opiate-cocaine addiction. ( Halikas, JA; Kemp, KD; Kuhn, KL, 1989) |
| "All ten cases reported little or no withdrawal symptoms after the last injection containing small amounts of heroin." | 1.27 | Street pharmacology: uses of cocaine and heroin in the treatment of addiction. ( Goldsmith, D; Hunt, DE; Lipton, DS; Strug, D, 1984) |
| "Clonidine treatment of NNAS remains strictly investigational at this time." | 1.27 | Clonidine treatment of neonatal narcotic abstinence syndrome. ( Caruso, KA; Cohen, DJ; Ehrenkranz, RA; Hoder, EL; Kleber, HD; Leckman, JF; Poulsen, J, 1984) |
| "85% of the newborns had withdrawal symptoms and 12% had convulsions the severity of which was not correlated with the type of drug abuse." | 1.27 | Investigation of 89 children born by drug-dependent mothers. I. Neonatal course. ( Andersen, GE; Buckley, W; Friis-Hansen, B; Olofsson, M, 1983) |
| " On reduction of opioid dosage he had visual and auditory hallucinations and showed deterioration of consciousness progressing to coma." | 1.27 | Unusual opioid withdrawal syndrome. A case-report. ( Grochow, LB; Hausheer, F; Kumor, KM, 1987) |
| "Methadone was shown to partially block the decrease in diet intake and the weight loss seen during morphine withdrawal." | 1.27 | Aspects of abstinence after morphine ingestion. ( Eriksson, PS; Rönnbäck, L; Rosengren, L; Wronski, A; Zeuchner, J, 1987) |
| "Clonidine-naltrexone treatment should succeed with patients receiving methadone doses up to 50 mg/day, facilitate naltrexone maintenance, and apply to many clinical settings." | 1.27 | The combined use of clonidine and naltrexone as a rapid, safe, and effective treatment of abrupt withdrawal from methadone. ( Charney, DS; Heninger, GR; Kleber, HD, 1986) |
| " These data suggest that maternal drug abuse and increased methadone dosage during pregnancy may predispose infants to the development of strabismus." | 1.27 | Occurrence of strabismus in infants born to drug-dependent women. ( Calhoun, JH; Ehrlich, S; Finnegan, LP; Matteucci, T; Nelson, LB, 1987) |
| "Monkeys receiving acetylmethadol thrice weekly were more active on dosing days, and less active on between-dose days, than while drug-free." | 1.27 | Variability in simian motor and social behavior with alternating-day acetylmethadol. ( Crowley, TJ; Macdonald, MJ; Zerbe, G, 1985) |
| "Naloxone failed to produce a significant increase in ACTH in methadone addicts while opiate-naive normal volunteers demonstrated a significant naloxone-induced release of ACTH." | 1.26 | Evidence for an endorphin dysfunction in methadone addicts: lack of ACTH response to naloxone. ( Extein, I; Finn, LB; Gold, MS; Kleber, HD; Martin, DA; Pottash, AL; Sweeney, DR, 1981) |
| "Clonidine-treated patients had significantly fewer symptoms than a comparable group of opioid addicts abruptly withdrawn from methadone." | 1.26 | Clonidine suppresses the opioid abstinence syndrome without clonidine-withdrawal symptoms: a blind inpatient study. ( Kleber, HD; Redmond, DE; Uhde, TW, 1980) |
| "The duration of opioid dependence was positively correlated with fraction I values." | 1.26 | Endorphin levels in opioid-dependent human subjects: a longitudinal study. ( Krivoy, W; McLellan, AT; O'Brien, CP; Terenius, L; Wahlström, A, 1982) |
| "That naloxone's effect was an expression of opiate withdrawal and not due to antagonism of depressed motility is also supported by the observation that naloxone significantly reduced the hatchability of opiate-exposed chicks and not of control chicks." | 1.26 | Prenatal withdrawal from opiates interferes with hatching of otherwise viable chick fetuses. ( Kuwahara, MD; Sparber, SB, 1981) |
| " Methadone dosing adjustments should be anticipated when phenytoin is initiated or discontinued in methadone-maintained patients." | 1.26 | Phenytoin-induced methadone withdrawal. ( Benowitz, NL; Jaffery, NF; Kreek, MJ; Pond, SM; Tong, TG, 1981) |
| "Early withdrawal symptoms persisted for three to four months, and mean growth parameters continued along their respective percentiles." | 1.26 | Early growth patterns of methadone-addicted infants. ( Burns, WJ; Chasnoff, IJ; Hatcher, R, 1980) |
| "Methadone HCl was administered daily to four stump-tailed macaques." | 1.26 | Sustained ingestion of methadone and the sleep of monkeys. ( Beck, EC; Dustman, RE; Snyder, EW, 1978) |
| "Methadone was given passively for 2 weeks by continuous i." | 1.26 | Effects of methadone and morphine maintenance on drug-seeking behavior in the dog. ( Jones, BE; Prada, JA, 1977) |
| "Thrombocytosis was not related to withdrawal symptoms or treatment (phenobarbital or paregoric)." | 1.26 | Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users. ( Burstein, Y; Giardina, PJ; Kandall, SR; Peterson, CM; Rausen, AR; Siljestrom, K, 1979) |
| "This incidence of SIDS was 5." | 1.26 | Sudden unexpected death in infants of narcotic-dependent mothers. ( Falciglia, H; Kandall, SR; Rajegowda, BK, 1978) |
| "When methadone was administered on a divided dosage regimen, there was a dramatic clinical improvement in both patients and a marked flattening of the curve of serum methadone levels." | 1.26 | Serum methadone as an aid in managing methadone maintenance patients. ( Thornton, TL; Wahl, GF; Walton, RG, 1978) |
| " It is suggested that reduction of methadone dosage in late pregnancy results in reduced incidence of withdrawal but must be carefully carried out." | 1.26 | Observation and treatment of neonatal narcotic withdrawal. ( Chappel, JN; Davis, R; Gumpel, J; Madden, JD; Mejia, A; Zuspan, F, 1977) |
| "Neonatal withdrawal symptoms appear to be related to individual variation in maternal metabolism of the drug, placental transfer of methadone, and most importantly, to the individual variations in the rate of excretion of methadone as reflected in the neonatal plasma t 1/2." | 1.26 | Pharmacologic observations on the neonatal withdrawal syndrome. ( Pippenger, CE; Rosen, TS, 1976) |
| " Nocturnal sleep was not markedly altered during the chronic administration of methadone." | 1.25 | Human sleep and EEG through a cycle of methadone dependence. ( Kay, DC, 1975) |
| " No significant association was found between maternal dosage of methadone in the last trimester of pregnancy and lentth of gestation, birth weight, or the reported presence of withdrawal symptoms in the neonate." | 1.25 | Results of 313 consecutive live births of infants delivered to patients in the New York City Methadone Maintenance Treatment Program. ( Bashkow, S; Calko, D; Newman, RG, 1975) |
| " Heroin addicts maintained on high dosage methadone (80-150 mg/day) also had depressed testosterone levels." | 1.25 | Plasma testosterone levels in heroin addiction and during methadone maintenance. ( Mendelson, JE; Mendelson, JH; Patch, VD, 1975) |
| "Naloxone hydrochloride was administered by regional intravenous injection (three patients) or by instillation into the conjunctival sac (10 patients) in addicts receiving methadone maintenance." | 1.25 | Ocular absorption of naloxone in narcotic addicts. ( Duncalf, D; Foldes, FF; Jeyaram, C; Tarter, R, 1975) |
| " Plasma testosterone levels decreased signifcantly when heroin dosage was between 45 and 65 mg/day contrasted to predrug base-line levels." | 1.25 | Effects of heroin and methadone on plasma cortisol and testosterone. ( Ellingboe, J; McDougle, M; Mendelson, JH; Meyer, RE; Mirin, SM, 1975) |
| " The maximum dosage permitted was 120 mg." | 1.25 | Control of methadone dosage by patients. ( Goldstein, A; Hansteen, RW; Horns, WH, 1975) |
| "Morphine was withdrawn by washing out the reservoir with drug vehicle." | 1.25 | An implanted reservoir of morphine solution for rapid induction of physical dependence in rats. ( Goode, PG, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 589 (53.84) | 18.7374 |
| 1990's | 165 (15.08) | 18.2507 |
| 2000's | 180 (16.45) | 29.6817 |
| 2010's | 124 (11.33) | 24.3611 |
| 2020's | 36 (3.29) | 2.80 |
| Authors | Studies |
|---|---|
| Pourhassanali, N | 1 |
| Zarbakhsh, S | 1 |
| Miladi-Gorji, H | 3 |
| Olsen, Y | 1 |
| Achuff, BJ | 1 |
| Lemming, K | 1 |
| Causey, JC | 1 |
| Sembera, KA | 1 |
| Checchia, PA | 1 |
| Heinle, JS | 1 |
| Ghanayem, NS | 1 |
| Manu, P | 1 |
| Rogozea, LM | 1 |
| Shulman, M | 1 |
| Wilson, M | 1 |
| Bindler, RJ | 1 |
| Stanek, K | 1 |
| Layton, ME | 1 |
| Quock, RM | 1 |
| Taylor, JL | 1 |
| Laks, J | 1 |
| Christine, PJ | 1 |
| Kehoe, J | 1 |
| Evans, J | 1 |
| Kim, TW | 1 |
| Farrell, NM | 1 |
| White, CS | 1 |
| Weinstein, ZM | 1 |
| Walley, AY | 3 |
| Carswell, N | 1 |
| Angermaier, G | 1 |
| Castaneda, C | 1 |
| Delgado, F | 1 |
| Townsend, EA | 2 |
| Blough, BE | 1 |
| Epstein, DH | 7 |
| Negus, SS | 4 |
| Shaham, Y | 1 |
| Banks, ML | 3 |
| Esposito, DB | 1 |
| Huybrechts, KF | 1 |
| Werler, MM | 1 |
| Straub, L | 1 |
| Hernández-Díaz, S | 1 |
| Mogun, H | 1 |
| Bateman, BT | 1 |
| Yue, JL | 1 |
| Yuan, K | 1 |
| Bao, YP | 2 |
| Meng, SQ | 1 |
| Shi, L | 1 |
| Fang, Q | 1 |
| Guo, XJ | 1 |
| Cao, L | 1 |
| Sun, YK | 1 |
| Lu, TS | 1 |
| Zeng, N | 1 |
| Yan, W | 1 |
| Han, Y | 1 |
| Sun, J | 1 |
| Shi, J | 4 |
| Kosten, TR | 21 |
| Xue, YX | 1 |
| Wu, P | 1 |
| Lu, L | 4 |
| Ford, J | 1 |
| Harthan, A | 1 |
| McGarvey, J | 1 |
| Mischler, M | 1 |
| K K, A | 1 |
| E J, M | 1 |
| D M, S | 1 |
| Bhoora, U | 2 |
| Gloeck, NR | 1 |
| Scheibe, A | 1 |
| Terasaki, D | 2 |
| Kulick, B | 1 |
| Calcaterra, S | 1 |
| Ray, L | 1 |
| Elkrief, L | 1 |
| Bastien, G | 1 |
| McAnulty, C | 1 |
| Bakouni, H | 1 |
| Hébert, FO | 1 |
| Socias, ME | 1 |
| Le Foll, B | 1 |
| Lim, R | 1 |
| Ledjiar, O | 1 |
| Marsan, S | 1 |
| Brissette, S | 1 |
| Jutras-Aswad, D | 1 |
| Dwivedi, I | 1 |
| Caldwell, AB | 1 |
| Zhou, D | 1 |
| Wu, W | 1 |
| Subramaniam, S | 1 |
| Haddad, GG | 1 |
| Martin, M | 1 |
| Englander, H | 1 |
| Calcaterra, SL | 2 |
| King, CE | 1 |
| Wood, DN | 1 |
| Koo, J | 1 |
| Cutler, AB | 1 |
| Vesel, TP | 1 |
| Padhan, M | 1 |
| Maiti, R | 1 |
| Mohapatra, D | 1 |
| Mishra, BR | 1 |
| Siemens, JA | 1 |
| Janse van Rensburg, M | 1 |
| Metpally, RP | 1 |
| Krishnamurthy, S | 1 |
| Moran, KM | 1 |
| Weller, AE | 1 |
| Crist, RC | 1 |
| Reiner, BC | 1 |
| Doyle, GA | 1 |
| Ferraro, TN | 1 |
| Radhakrishna, U | 1 |
| Bahado-Singh, R | 1 |
| Troiani, V | 1 |
| Berrettini, WH | 1 |
| Walters, RA | 1 |
| Izquierdo, M | 1 |
| Rodriguez, JC | 1 |
| Stevens, JS | 1 |
| Lavandosky, G | 1 |
| Hu, WL | 1 |
| Tsai, MC | 1 |
| Kuo, CE | 1 |
| Liu, CT | 2 |
| Wu, SY | 1 |
| Wu, TC | 1 |
| Hung, YC | 1 |
| Elias, AM | 1 |
| Pepin, MJ | 1 |
| Brown, JN | 1 |
| Fluyau, D | 1 |
| Revadigar, N | 1 |
| Pierre, CG | 1 |
| Tripathi, R | 1 |
| Rao, R | 1 |
| Dhawan, A | 1 |
| Jain, R | 1 |
| Sinha, S | 1 |
| Lodi, S | 1 |
| Li, Y | 3 |
| Bernson, D | 1 |
| Babakhanlou-Chase, H | 1 |
| Land, T | 1 |
| Larochelle, MR | 1 |
| Akbari, P | 1 |
| Najafi, M | 1 |
| Rezaei, AM | 1 |
| Kinasz, KR | 1 |
| Herbst, ED | 1 |
| Kalapatapu, RK | 1 |
| Jones, S | 1 |
| Jack, B | 1 |
| Kirby, J | 1 |
| Wilson, TL | 1 |
| Murphy, PN | 1 |
| Abbaszadeh-Mashkani, S | 1 |
| Hoque, SS | 1 |
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| Rothstein, P | 1 |
| Gould, JB | 1 |
| Jorgensen, F | 1 |
| Zavell, PM | 1 |
| Inaba, DS | 1 |
| Gay, GR | 2 |
| Whitehead, CA | 1 |
| Newmeyer, JA | 1 |
| Bergin, D | 1 |
| Triplett, JN | 1 |
| Beeler, GW | 1 |
| Ghosh, PK | 1 |
| Maslansky, RA | 1 |
| Smith, BB | 1 |
| Blachley, PH | 1 |
| Ryan, J | 1 |
| Rolde, EJ | 1 |
| Statzer, DE | 1 |
| Cassidy, WJ | 1 |
| Poze, RS | 1 |
| Sheppard, CW | 1 |
| Smith, DE | 1 |
| Glatt, M | 1 |
| Cary, W | 1 |
| Masó, G | 1 |
| Swartz, DP | 1 |
| Leblanc, W | 1 |
| Hussain, MZ | 1 |
| Harinath, M | 1 |
| Kumar, R | 1 |
| Stolerman, IP | 1 |
| Freed, EX | 1 |
| Fazzaro, J | 1 |
| Hymowitz, N | 1 |
| Tice, AD | 1 |
| Pierson, PS | 1 |
| Howard, P | 1 |
| Erikson, JH | 1 |
| Maidlow, ST | 1 |
| Berman, H | 1 |
| Hess, JP | 1 |
| Fraser, A | 1 |
| Annunziato, D | 1 |
| Reddy, AM | 1 |
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| Goode, PG | 1 |
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| Lipkowitz, MH | 1 |
| Schwartz, DW | 1 |
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| Berkelhamer, JE | 1 |
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| Idänpään-Heikkilä, P | 1 |
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| Williams, HR | 2 |
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| Lasagna, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adjuvant Laser Meridian Massage in Heroin Addicts With Methadone Treatment: an Observational Case-controlled Study[NCT04003077] | 30 participants (Anticipated) | Interventional | 2019-02-26 | Recruiting | |||
| Auricular Acupressure as an Adjunct Treatment for Opioid Tapering in a Pediatric Cardiac Intensive Care Unit: A Pilot Feasibility Study[NCT05025384] | 40 participants (Actual) | Interventional | 2021-10-25 | Completed | |||
| A Phase I, Open-Label, Single-Sequence Drug-Drug Interaction Trial in Subjects on Stable Methadone Maintenance Therapy, to Investigate the Potential Interaction Between Telaprevir 750 mg q8h and Methadone, at Steady-State[NCT00933283] | Phase 1 | 18 participants (Actual) | Interventional | 2009-07-31 | Completed | ||
| Maternal Opioid Treatment: Human Experimental Research[NCT00271219] | Phase 3 | 175 participants (Actual) | Interventional | 2005-07-31 | Completed | ||
| A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407] | 55 participants (Actual) | Interventional | 2017-04-20 | Completed | |||
| A Phase I, Open-label, Single-sequence Drug-drug Interaction Trial in Subjects on Stable Methadone Maintenance Therapy, to Investigate the Potential Interaction Between TMC278 25 mg q.d. and Methadone, at Steady-state.[NCT00744770] | Phase 1 | 13 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| Effect of Multiple Dosing With BI 201335 on the Safety, Pharmacokinetics and Pharmacodynamics of Steady-state Methadone and Buprenorphine/Naloxone in Subjects on Stable Addiction Management Therapy[NCT01637922] | Phase 1 | 34 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| Randomised, Controlled Clinical Study Regarding the Feasibility of Converting Opiate Dependents From Methadone Substitutes to Slow Release Morphine Sulphate (Sevre-Long™)[NCT01079117] | Phase 3 | 276 participants (Actual) | Interventional | 2006-10-31 | Completed | ||
| A Randomized Controlled Pilot Trial of Gabapentin for the Treatment of Benzodiazepine Abuse in Methadone Maintenance Patients[NCT00420771] | Phase 2 | 19 participants (Actual) | Interventional | 2007-01-31 | Completed | ||
| A Prospective, Randomized Trial of the Effect of Standard of Care Reduced Dose Versus Full Dose Buprenorphine/Naloxone in the Perioperative Period on Pain Control and Post Operative Opioid Use Disorder Symptoms[NCT03266445] | Phase 4 | 76 participants (Anticipated) | Interventional | 2018-10-05 | Not yet recruiting | ||
| Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit[NCT02025855] | Phase 4 | 46 participants (Anticipated) | Interventional | 2014-01-31 | Enrolling by invitation | ||
| Place of Low-Dose Naltrexone in Opiate Detoxification[NCT00135759] | Phase 2 | 174 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
| A Double Blind, Randomized Clinical Trial Comparing Postoperative Narcotic Usage in Patients Receiving Periarticular Liposomal Bupivicaine vs. Those Patients Receiving Standard Periarticular Joint Injections[NCT02682498] | Phase 4 | 38 participants (Actual) | Interventional | 2013-10-31 | Completed | ||
| Time to Detox: A Patient-Centered Comparison of Length of Detoxification Treatment and Time to Naltrexone Maintenance Therapy in Opioid-Dependent Individuals[NCT03678792] | Phase 3 | 0 participants (Actual) | Interventional | 2019-11-15 | Withdrawn (stopped due to Infeasible to conduct at this time.) | ||
| Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone in Human Subjects[NCT00504413] | Phase 1 | 20 participants (Anticipated) | Interventional | 2007-07-31 | Recruiting | ||
| Genetic, Epigenetic, Psychosocial, and Biological Determinants of Post-surgical Pain After Pectus or Spine Surgery[NCT04031716] | 600 participants (Anticipated) | Interventional | 2018-07-06 | Enrolling by invitation | |||
| [NCT00261183] | Phase 3 | 100 participants | Interventional | 2004-12-31 | Recruiting | ||
| Efficacy of Clonidine in the Treatment of Neonatal Abstinence Syndrome: A Prospective, Double Blind, Randomized Controlled Trial[NCT00510016] | Phase 2 | 80 participants (Actual) | Interventional | 2002-07-31 | Completed | ||
| Analgesic Efficacy of Testosterone Replacement in Hypogonadal Opioid-treated Chronic Pain Patients: A Pilot Study.[NCT00398034] | Phase 2 | 0 participants (Actual) | Interventional | 2006-10-30 | Withdrawn (stopped due to The original PI (David Siegel) Left the VA) | ||
| fMRI Imaging of Opioid Withdrawal in Healthy Human Volunteers[NCT01006707] | 15 participants (Actual) | Interventional | 2010-11-30 | Completed | |||
| Does Preoperative Pain Medication Management Influence Surgical Outcomes in Spinal Fusion: A Randomized Controlled Study[NCT04095624] | 84 participants (Anticipated) | Interventional | 2019-09-09 | Recruiting | |||
| Can Cognitive-bias Modification Training During Inpatient Alcohol Detoxification Reduce Relapse Rates Post-discharge?[NCT02634476] | 83 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| Cocaine Effects in Humans: Physiology and Behavior[NCT00000200] | Phase 2 | 19 participants (Actual) | Interventional | 1997-01-31 | Completed | ||
| An Innovative Digital Smoking Cessation Intervention for Low-Income Adults With Substance Use Disorder[NCT04419922] | 100 participants (Actual) | Observational | 2020-04-02 | Active, not recruiting | |||
| Participatory System Dynamics vs Audit and Feedback: A Cluster Randomized Trial of Mechanisms of Implementation Change to Expand Reach of Evidence-based Addiction and Mental Health Care[NCT04356274] | 720 participants (Anticipated) | Interventional | 2019-02-01 | Enrolling by invitation | |||
| Behavioral Pharmacological Examination of a Novel Buprenorphine Induction Method Among Individuals Who Use Fentanyl[NCT06089707] | Phase 3 | 25 participants (Anticipated) | Interventional | 2024-01-15 | Not yet recruiting | ||
| NanaBis™ an Oro-buccal Administered Equimolar d9-THC & CBD Formulation as Monotherapy for Management of Opioid Requiring Bone Pain Due to Metastatic Cancer: Phase 3 Multi Centre Blinded Randomized Withdrawal Active & Placebo Controlled Trial[NCT04808531] | Phase 3 | 360 participants (Anticipated) | Interventional | 2023-11-30 | Not yet recruiting | ||
| Examination of Palonosetron and Hydroxyzine Pre-treatment as a Possible Method to Reduce the Objective Signs of Experimentally-induced Acute Opioid Withdrawal in Humans: a Double-blind, Randomized, Placebo-controlled Crossover Study[NCT00661674] | 10 participants (Actual) | Interventional | 2008-04-30 | Completed | |||
| Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD: A Pilot Double-blind, Randomized Clinical Trial[NCT04759703] | Phase 2/Phase 3 | 80 participants (Anticipated) | Interventional | 2022-01-24 | Recruiting | ||
| 5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence[NCT01549652] | 133 participants (Actual) | Interventional | 2011-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00271219)
Timeframe: birth
| Intervention | cm (Mean) |
|---|---|
| A Methadone | 33.0 |
| B Buprenorphine | 33.8 |
(NCT00271219)
Timeframe: delivery until hospital discharge (min=2 days, max=79 days)
| Intervention | days (Mean) |
|---|---|
| A Methadone | 17.5 |
| B Buprenorphine | 10.0 |
NAS was measured with the MOTHER NAS scale, which includes 28 items, 19 of which are used for scoring and medication decisions. Scores can range from 0 to 42, with higher scores indicating more severe withdrawal. (NCT00271219)
Timeframe: minimum twice daily from birth until NAS no longer measured (min=10 days)
| Intervention | Score on the scale (Mean) |
|---|---|
| A Methadone | 12.8 |
| B Buprenorphine | 11.0 |
(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | percentage of HIV risk behaviors (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
Pregnant women maintained on an opioid agonist medication may require upward adjustment to their medication during the course of pregnant. The Dose Adequacy Measure represented a recordation of dosing adjustments during the course of the study. (NCT00271219)
Timeframe: from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | dose increase per trimester (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
The Addiction Severity Index is a structured clinical interview that assesses problem severity in 7 areas of functioning: alcohol use, drug use, medical, legal, employment, psychosocial, and psychiatric status. Each area of functioning yields a composite scale score between 0 and 1, with higher scores indicating greater problem severity in that area. Only the psychosocial index was examined in this study. (NCT00271219)
Timeframe: at delivery
| Intervention | Score on the scale (Mean) |
|---|---|
| Methadone | .014 |
| Buprenorphine | .088 |
(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | percentage of drug use (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
Neonatal abstinence syndrome (NAS) characterized by hyperirritability of the central nervous system and dysfunction in the autonomic nervous system, gastrointestinal tract, and respiratory system.11 When left untreated, NAS can result in serious illness (e.g., diarrhea, feeding difficulties, weight loss, and seizures) and death. (NCT00271219)
Timeframe: From birth until hospital discharge (min=4 days, max=10, depending on site)
| Intervention | participants (Number) |
|---|---|
| A Methadone | 41 |
| B Buprenorphine | 27 |
Total amount in mg (NCT00271219)
Timeframe: Start of NAS treatment until discontinuation of NAS treatment (min=0 days, max=76 days)
| Intervention | mg (Mean) |
|---|---|
| A Methadone | 10.4 |
| B Buprenorphine | 1.1 |
These are the unadjusted summary statistics on the original scale for area under the concentration time curve (AUC) of faldaprevir in plasma over a uniform dosing interval from 0 to 24 hours. (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [pg*h/ml] (Geometric Mean) | |
|---|---|---|
| BUPRENORPHINE with FDV (Day 9) | BUPRENORPHINE alone (Day 1) | |
| Buprenorphine/Naloxone (Suboxone) | 58700 | 54000 |
These are the unadjusted summary statistics on the original scale for steady-state plasma concentration of faldaprevir 24 hours after the last dose (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [pg/mL] (Geometric Mean) | |
|---|---|---|
| BUPRENORPHINE with FDV (Day 9) | BUPRENORPHINE alone (Day 1) | |
| Buprenorphine/Naloxone (Suboxone) | 1110 | 904 |
These are the unadjusted summary statistics on the original scale for the maximum measured concentration of faldaprevir in plasma at steady state. (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [pg/ml] (Geometric Mean) | |
|---|---|---|
| BUPRENORPHINE with FDV (Day 9) | BUPRENORPHINE alone (Day 1) | |
| Buprenorphine/Naloxone (Suboxone) | 7610 | 8240 |
These are the unadjusted summary statistics on the original scale for area under the concentration time curve (AUC) of faldaprevir in plasma over a uniform dosing interval from 0 to 24 hours. (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [pg*h/ml] (Geometric Mean) | |
|---|---|---|
| NALOXONE with FDV (Day 9) | NALOXONE alone (Day 1) N=12 | |
| Buprenorphine/Naloxone (Suboxone) | 971 | 1000 |
These are the unadjusted summary statistics on the original scale for steady-state plasma concentration of faldaprevir 24 hours after the last dose (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [pg/mL] (Geometric Mean) | |
|---|---|---|
| NALOXONE with FDV (Day 9) | NALOXONE alone (Day 1) | |
| Buprenorphine/Naloxone (Suboxone) | 23.4 | 25.6 |
These are the unadjusted summary statistics on the original scale for the maximum measured concentration of faldaprevir in plasma at steady state. (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [pg/mL] (Geometric Mean) | |
|---|---|---|
| NALOXONE with FDV (Day 9) | NALOXONE alone (Day 1) N=13 | |
| Buprenorphine/Naloxone (Suboxone) | 284 | 357 |
These are the unadjusted summary statistics on the original scale for area under the concentration time curve (AUC) of faldaprevir in plasma over a uniform dosing interval from 0 to 24 hours. (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [pg*h/ml] (Geometric Mean) | |
|---|---|---|
| NORBUPRENORPHINE with FDV (Day 9) | NORBUPRENORPHINE alone (Day 1) | |
| Buprenorphine/Naloxone (Suboxone) | 59200 | 42900 |
These are the unadjusted summary statistics on the original scale for steady-state plasma concentration of faldaprevir 24 hours after the last dose (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [pg/mL] (Geometric Mean) | |
|---|---|---|
| NORBUPRENORPHINE with FDV (Day 9) | NORBUPRENORPHINE alone (Day 1) | |
| Buprenorphine/Naloxone (Suboxone) | 2080 | 2010 |
These are the unadjusted summary statistics on the original scale for the maximum measured concentration of faldaprevir in plasma at steady state. (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [pg/mL] (Geometric Mean) | |
|---|---|---|
| NORBUPRENORPHINE with FDV (Day 9) | NORBUPRENORPHINE alone (Day 1) | |
| Buprenorphine/Naloxone (Suboxone) | 3690 | 2770 |
The OOWS is conducted by a trained independent examiner for either the presence or absence of the following symptoms during a 10 minute observation period at designated times during the trial. The minimum possible OOWS score is 0 and the maximum possible score is 13. Objective criteria: Yawning, Rhinorrhoea, Piloerection, perspiration, lacrimation, mydriasis, hot and cold flushes, restlessness, vomiting, tremors, anxiety, muscle twitches, abdominal cramps. Higher score indicates increasing severity of opiate withdrawal syndrome. (NCT01637922)
Timeframe: Baseline, Day 2, Day 3, Day 4, Day 5, Day 6, Day 7, Day 8, Day 9, Day 10, Day 11, Day 12 and End of treatment
| Intervention | units on a scale (Median) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 2 | Day 3 | Day 4 (N=15,18) | Day 5 (N=15,18) | Day 6 (N=15,18) | Day 7 (N=15,15) | Day 8 (N=15,15) | Day 9 (N=15,15) | Day 10 (N=15,15) | Day 11 (N=15,15) | Day 12 (N=15,15) | End of Treatment (EOT) (N=14,16) | |
| Buprenorphine/Naloxone (Suboxone) | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| Methadone Group | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
The SOWS is a subjective scale self-evaluated by the subject. The SOWS shows items reflecting the common motor, autonomic, gastrointestinal, musculo-skeletal, and psychic symptoms of opiate withdrawal. Subjects are instructed to rate each symptom on a scale of 0 to 4 (0=not at all, 1=a little, 2=moderately, 3=quite a bit, 4=extremely) at designated times [c.f. Section 3.1]. The minimum possible SOWS score is 0, the maximum 64. The following subjective criteria are answered by the subject using the scale below: 1) I feel anxious, 2) I feel like yawning 3) I am perspiring, 4) My eyes are watering, 5) My nose is running, 6) I have goose flesh, 7) I am shaking 8) I have hot flushes, 9) I have cold flushes, 10) My bones and muscles ache, 11) I feel restless, 12) I feel nauseous, 13) I feel like vomiting, 14) My muscles twitch, 15) I have cramps in my stomach, 16) I feel like shooting up now. Higher score indicates increasing severity of opiate withdrawal syndrome. (NCT01637922)
Timeframe: Baseline, Day 2, Day 3, Day 4, Day 5, Day 6, Day 7, Day 8, Day 9, Day 10, Day 11, Day 12 and End of treatment
| Intervention | units on a scale (Median) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Day 2 | Day 3 | Day 4 (N=15,18) | Day 5 (N=15,18) | Day 6 (N=15,18) | Day 7 (N=15,15) | Day 8 (N=15,15) | Day 9 (N=15,15) | Day 10 (N=15,15) | Day 11 (N=15,15) | Day 12 (N=15,15) | End of Treatment (EOT) (N=14,16) | |
| Buprenorphine/Naloxone (Suboxone) | -1.0 | 0.0 | 0.0 | -0.5 | -0.5 | -1.0 | -1.0 | -1.0 | -1.0 | -1.0 | -1.0 | -1.0 |
| Methadone Group | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
These are the unadjusted summary statistics on the original scale for area under the concentration time curve (AUC) of faldaprevir in plasma over a uniform dosing interval from 0 to 24 hours. (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [ng*h/mL] (Geometric Mean) | |
|---|---|---|
| R-methadone with FDV (Day 9) | R-methadone alone (Day 1) | |
| Methadone Group | 6990 | 5920 |
These are the unadjusted summary statistics on the original scale for steady-state plasma concentration of faldaprevir 24 hours after the last dose (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [ng/mL] (Geometric Mean) | |
|---|---|---|
| R-methadone with FDV (Day 9) | R-methadone alone (Day 1) | |
| Methadone Group | 235 | 210 |
These are the unadjusted summary statistics on the original scale for the maximum measured concentration of faldaprevir in plasma at steady state. (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [ng/ml] (Geometric Mean) | |
|---|---|---|
| R-methadone with FDV (Day 9) | R-methadone alone (Day 1) | |
| Methadone Group | 393 | 345 |
These are the unadjusted summary statistics on the original scale for area under the concentration time curve (AUC) of faldaprevir in plasma over a uniform dosing interval from 0 to 24 hours. (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [ng*h/ml] (Geometric Mean) | |
|---|---|---|
| S-methadone with FDV (Day 9) | S-methadone alone (Day 1) | |
| Methadone Group | 7610 | 6470 |
These are the unadjusted summary statistics on the original scale for steady-state plasma concentration of faldaprevir 24 hours after the last dose (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [ng/mL] (Geometric Mean) | |
|---|---|---|
| S-methadone with FDV (Day 9) | S-methadone alone (Day 1) | |
| Methadone Group | 231 | 207 |
These are the unadjusted summary statistics on the original scale for the maximum measured concentration of faldaprevir in plasma at steady state. (NCT01637922)
Timeframe: 0 hours, 0.5 hours, 1 hour, 1.5 hours, 2 hours, 2.5 hours, 3 hours, 4 hours, 6 hours, 8 hours, 12 hours and 24 hours on Day 1 and Day 9
| Intervention | [ng/mL] (Geometric Mean) | |
|---|---|---|
| S-methadone with FDV (Day 9) | S-methadone alone (Day 1) | |
| Methadone Group | 474 | 425 |
Comparing the mean reduction change in Benzodiazepine use per day when comparing the baseline week prior to study entry to the last week of study participation based on the Time Line Follow Back (NCT00420771)
Timeframe: data collected during 8 weeks of trial or length of participation
| Intervention | milligrams/day (Mean) |
|---|---|
| Active Medication | 4.0 |
| Placebo | 2.3 |
A comparison of group means between the control group and study group with regards to 48 hour opioid use. (NCT02682498)
Timeframe: 48 hours
| Intervention | morphine equivalents (Mean) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 5.32 |
| Standard Periarticular Joint Injection | 5.07 |
Opioid use will be monitored daily from the time of admission in comparison of standard knee injection post-operatively. (NCT02682498)
Timeframe: Up to 48 hours
| Intervention | Total Morphine Equivalents (Mean) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 100 |
| Standard Periarticular Joint Injection | 103 |
Examining the average daily patient pain score in comparison of standard knee injection post-operatively. The measure is the Visual-Analog-Scale (VAS) for subjective pain reporting. The minimum 0 (no pain) and the maximum is 10 (worst pain imagineable). There is only one measure in the scale (i.e. there are no subscales). Lower scores on the VAS scale equate to less pain and are therefore desirable. (NCT02682498)
Timeframe: Up to 48 hours
| Intervention | Visual Analog Scale Rating (Mean) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 4.75 |
| Standard Periarticular Joint Injection | 5.75 |
Examining the post-operative complication in comparison of standard knee injection post-operatively. (NCT02682498)
Timeframe: Up to 1 month
| Intervention | complications (Number) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 0 |
| Standard Periarticular Joint Injection | 0 |
Post anesthesia care unit (recovery room) opioid use in total mg morphine IV equivalent in comparison of standard knee injection post-operatively. (NCT02682498)
Timeframe: Up to 48 hours
| Intervention | Total morphine equivalents (Median) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 5 |
| Standard Periarticular Joint Injection | 5 |
The OOWS consists of 13 observable physical symptoms that are assessed over a five-minute observation period and scored as present (score of 1) or absent (score of 0). The total OOWS scores is determined by summing the scores of the 13 items. OOWS scores can range from a low of 0 to a high of 13. A score of 0 would suggest that no objective signs of withdrawal were observed while a score of 13 would suggest that every observable sign of withdrawal was observed. (NCT01006707)
Timeframe: 15 Minutes Following Ondansetron or Placebo Administration
| Intervention | units on a scale (Mean) |
|---|---|
| Ondansetron | 2.7 |
| Placebo | 2.2 |
The OOWS consists of 13 observable physical symptoms that are assessed over a five-minute observation period and scored as present (score of 1) or absent (score of 0). The total OOWS scores is determined by summing the scores of the 13 items. OOWS scores can range from a low of 0 to a high of 13. A score of 0 would suggest that no objective signs of withdrawal were observed while a score of 13 would suggest that every observable sign of withdrawal was observed. (NCT01006707)
Timeframe: 5 Minutes Following Ondansetron or Placebo Administration
| Intervention | units on a scale (Mean) |
|---|---|
| Ondansetron | 1 |
| Placebo | 2 |
The SOWS consists of 16 physical and emotional symptoms that are rated by the participant on a scale from 0 (not at all) to 4 (extremely), to indicate the extent to which the symptom describes how they are feeling at the time. The total SOWS score is determined by summing the scores of the 16 items. Scores range from a low of 0 to a high of 64. A score of 0 would suggest that the individual is experiencing no symptoms of withdrawal while a score of 64 would suggest that the individual is experiencing all 16 symptoms of withdrawal to the fullest extent possible. (NCT01006707)
Timeframe: 20 minutes following Ondansetron or Placebo administration
| Intervention | units on a scale (Mean) |
|---|---|
| Ondansetron | 5.7 |
| Placebo | 8.1 |
Changes are reporting using Spearman's correlation coefficient, using within-subject factors of time (pre-naloxone, post-naloxone) and pre-treatment (placebo, ondansetron). Changes in Objective Opioid Withdrawal Scale (OOWS) and Subjective Opioid Withdrawal Scale (SOWS) with correlation coefficient >0.45 are reported. The OOWS consists of 13 observable physical symptoms assessed over a 5-minute observation period and scored as present (score of 1) or absent (score of 0). The total OOWS scores is determined by summing the scores of the 13 items. OOWS scores can range from 0 to 13; lower scores correspond to fewer symptoms. SOWS consists of 16 physical and emotional symptoms rated by the participant on a scale from 0 (not at all) to 4 (extremely), to indicate the extent to which the symptom describes how they are feeling at the time. The total SOWS score is determined by summing the scores of the 16 items. Scores range from 0 to 64; lower scores correspond to fewer symptoms. (NCT01006707)
Timeframe: 36 minutes
| Intervention | correlation coefficient (Number) | |||||
|---|---|---|---|---|---|---|
| Left inferior frontal gyrus, orbital (OOWS) | Right inferior frontal gyrus, orbital (OOWS) | Right superior frontal gyrus, medial (SOWS) | Right inferior frontal gyrus, orbital (SOWS) | Left superior temporal gyrus (OOWS) | Left caudate head (SOWS) | |
| All Ondansetron | 0.519 | 0.562 | 0.478 | 0.486 | -0.612 | 0.475 |
"The OOWS is a 13-item instrument documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score possible = 13, minimum score possible = 0. T=15 minutes post naloxone administration coordinates with T = 180 (min) for the entire study session.~OOWS scores at T=180 is the primary outcome measure of the study compared with baseline OOWS scores at T=-30 (30 minutes prior to study medication administration). Reported time frames are in relation to time past since administration of study medications.~Mean post-Naloxone OOWS scores (+/- SEM) were determined for pretreatment groups" (NCT00661674)
Timeframe: Change from baseline in OOWS score at 180 minutes (15 minutes post naloxone administration)
| Intervention | units on a scale (OOWS Scale) (Mean) |
|---|---|
| Placebo | 3.5 |
| Palonosetron | 1.0 |
| Palonosetron + Hydroxyzine | 0 |
"The SOWS score is composed of 16 subjective symptoms rated on a scale of 0 to 4 (0=not at all, 4=extremely) based on what subjects were experiencing at the time of testing. 15 minutes post naloxone administration coordinates with T = 180 (min) for the entire study session.~The highest score possible (64) would indicate that the individual was experiencing every symptom of opioid withdrawal to the fullest extent possible while the lowest score (0) would indicate that the individual was not experiencing any symptoms of opioid withdrawal.~Mean post-naloxone SOWS scores (+/- SEM) were computed for pretreatment groups: Placebo, palonosetron, and palonosetron with hydroxyzine" (NCT00661674)
Timeframe: Change from baseline in SOWS score at 180 minutes (15 minutes post naloxone administration)
| Intervention | units on a scale (SOWS Scale) (Mean) |
|---|---|
| Placebo | 6.0 |
| Palonosetron | 4.0 |
| Palonosetron + Hydroxyzine | 3.5 |
The Beck Depression Inventory (a 21-item self-report multiple-choice inventory) yields a single summed score between 0 and 63; higher scores indicate more severe depression. Change is from baseline score (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken prior to receiving ondansetron or placebo, at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)
| Intervention | units on a scale (Mean) |
|---|---|
| Prevention of Opioid Withdrawal | -0.44 |
The VAS is a 0 to 100 millimeter scale where 0 corresponds to no pain and 100 to extreme pain, used by participants to indicated their level of pain over the last two weeks. Change is from baseline score for average level of pain (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken prior to receiving ondansetron or placebo, at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)
| Intervention | units on a scale (Mean) |
|---|---|
| Prevention of Opioid Withdrawal | -2.68 |
The Roland-Morris Disability Index is a 24-question instrument used to assess level of disability from lower back pain. Scores range from 0-24 with lower scores corresponding to fewer symptoms. Change is from baseline score (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken prior to receiving ondansetron or placebo, at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)
| Intervention | units on a scale (Mean) |
|---|---|
| Prevention of Opioid Withdrawal | -2.59 |
The Beck Depression Inventory (a 21-item self-report multiple-choice inventory) yields a single summed score between 0 and 63; higher scores indicate more severe depression. Change is from baseline score (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in BDIS (Ondansetron) | Change in BDIS (Placebo) | |
| Prevention of Physical Dependence | -0.6 | 0.2 |
"Originally developed by Handelsman, the Objective Opioid Withdrawal Scale (OOWS) score is a well-characterized measure of opioid withdrawal in humans, calculated as the sum of a 13-item physician assessment documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. The minimum score of 0 means the patient is not showing any signs of opioid withdrawal. The maximum score of 13 signifies all signs of opioid withdrawal to the largest extent possible.~Immediately prior to ondansetron or placebo administration a baseline OOWS score was taken. 30 minutes later participants received naloxone, then 15 minutes later an OOWS score was taken. If deemed necessary by the clinician, participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an OOWS score was taken. Change from the baseline OOWS score to the score assessed following the last naloxone dose is reported." (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in OOWS (Ondansetron) | Change in OOWS (Placebo) | |
| Prevention of Opioid Withdrawal | 3.6 | 3.6 |
"Originally developed by Handelsman, the OOWS score is a well-characterized measure of opioid withdrawal in humans, calculated as the sum of a 13-item physician assessment documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. The maximum score is 13 and suggests the patient is showing all signs of opioid withdrawal to the largest extent possible. The minimum score of 0 suggests the patient is not showing any signs of opioid withdrawal.~Immediately prior to ondansetron or placebo administration a baseline OOWS score was taken. 30 minutes later participants received naloxone, then 15 minutes later an OOWS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an OOWS score was taken. Change from the baseline OOWS score to the score assessed following the last naloxone dose is reported." (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in OOWS (Ondansetron) | Change in OOWS (Placebo) | |
| Prevention of Physical Dependence | 4.5 | 4.2 |
The VAS is a 0 to 100 millimeter scale where 0 corresponds to no pain and 100 to extreme pain, used by participants to indicated their level of pain over the last two weeks. Change is from baseline score for average level of pain (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in VAS Score (Ondansetron) | Change in VAS Score (Placebo) | |
| Prevention of Physical Dependence | -2.9 | -2.8 |
The Roland-Morris Disability Index is a 24-question instrument used to assess level of disability from lower back pain. Scores range from 0-24 with lower scores corresponding to fewer symptoms. Change is from baseline score (taken at the beginning of the first study visit, prior to beginning of titration into morphine) to the score taken after taking morphine for 30 days (score taken at the beginning of second study visit). (NCT01549652)
Timeframe: 2 study days 1 month apart (at the start of each study visit)
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in RMDI (Ondansetron) | Change in RMDI (Placebo) | |
| Prevention of Physical Dependence | -4.6 | -2.0 |
The Subjective Opioid Withdrawal Score (SOWS) score is calculated as the sum of 16 subjective patient-reported symptom scores rated on a scale of 0 to 4 (0=not at all, 4=extremely) based on what subjects were experiencing at the time of testing. A maximum score of 64 would suggest the patient is experiencing the symptoms of withdrawal to the maximum extent possible while the lowest score of 0 would suggest the patient is not experiencing any of the symptoms of withdrawal. Immediately prior to ondansetron or placebo administration a baseline SOWS score was taken. 30 minutes later participants received naloxone, then 15 minutes later an SOWS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an SOWS score was taken. Change from the baseline SOWS score to the score assessed following the last naloxone dose is reported (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in SOWS (Ondansetron) | Change in SOWS (Placebo) | |
| Prevention of Opioid Withdrawal | 12.5 | 12.2 |
The SOWS score is composed of 16 subjective symptoms rated on a scale of 0 to 4 (0=not at all, 4=extremely) based on what subjects were experiencing at the time of testing. A maximum score of 64 would suggest the patient is experiencing the symptoms of withdrawal to the maximum extent possible while the lowest score of 0 would suggest the patient is not experiencing any of the symptoms of withdrawal. Immediately prior to ondansetron or placebo administration a baseline SOWS score was taken. 30 minutes later participants received naloxone, then 15 minutes later an SOWS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an SOWS score was taken. Change from the baseline SOWS score to the score assessed following the last naloxone dose is reported (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in SOWS (Ondansetron) | Change in SOWS (Placebo) | |
| Prevention of Physical Dependence | 16.4 | 12.0 |
Profile of Mood States (POMS) is a 65-question survey of how participants have been feeling over the past week, assessing tension, depression, anger, fatigue, confusion and vigor. Each question is on a 5-point scale: 0 (not at all) to 4 (extremely). Overall score range: 0 to 200 (lower scores corresponding to fewer symptoms), calculated by adding total scores for tension, depression, anger, fatigue and confusing, and subtracting that total score from the total score for vigor. Immediately prior to ondansetron or placebo administration a baseline POMS score was taken. 30 minutes later participants received naloxone, then 15 minutes later a POMS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an POMS score was taken. Change from the baseline POMS score to the score assessed following the last naloxone dose is reported. (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in POMS Score (Ondansetron) | Change in POMS Score (Placebo) | |
| Prevention of Opioid Withdrawal | 29.3 | 28.3 |
(Profile of Mood States) POMS is a 65-question survey of how participants have been feeling over the past week, assessing tension, depression, anger, fatigue, confusion and vigor. Each question is on a 5-point scale: 0 (not at all) to 4 (extremely). Overall score range: 0 to 200 (lower scores corresponding to fewer symptoms), calculated by adding total scores for tension, depression, anger, fatigue and confusing, and subtracting that total score from the total score for vigor. Immediately prior to ondansetron or placebo administration a baseline POMS score was taken. 30 minutes later participants received naloxone, then 15 minutes later a POMS score was taken. If necessary (as deemed by the clinician), participants may have received a second naloxone dose (25 minutes following 1st naloxone dose), then 15 minutes later an POMS score was taken. Change from the baseline POMS score to the score assessed following the last naloxone dose is reported. (NCT01549652)
Timeframe: Baseline; 15 minutes following last naloxone dose
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Change in POMS (Ondansetron) | Change in POMS (Placebo) | |
| Prevention of Physical Dependence | 36.1 | 29.2 |
117 reviews available for methadone and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
What Is Addiction? History, Terminology, and Core Concepts.
Topics: Adolescent; Analgesics, Opioid; Behavior; Behavior, Addictive; Buprenorphine; Comprehensive Health C | 2022 |
Management of opioid withdrawal and initiation of medications for opioid use disorder in the hospital setting.
Topics: Analgesics, Opioid; Antiemetics; Benzodiazepines; Buprenorphine; Hospitals; Humans; Methadone; Naltr | 2022 |
Factors that distinguish opioid withdrawal during induction with buprenorphine microdosing: a configurational analysis.
Topics: Analgesics, Opioid; Buprenorphine; Heroin; Humans; Methadone; Narcotics; Opioid-Related Disorders; S | 2022 |
Efficacy and safety of tramadol in the treatment of opioid withdrawal: A meta-analysis of randomized controlled trials.
Topics: Bayes Theorem; Buprenorphine; Clonidine; Humans; Methadone; Narcotics; Opioid-Related Disorders; Ran | 2023 |
Adjunctive memantine for opioid use disorder treatment: A systematic review.
Topics: Analgesics, Opioid; Buprenorphine; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Hum | 2019 |
Medications Development for Treatment of Opioid Use Disorder.
Topics: Analgesics, Opioid; Buprenorphine; Choice Behavior; Drug Development; Evidence-Based Medicine; Human | 2021 |
Clinical benefits and risks of N-methyl-d-aspartate receptor antagonists to treat severe opioid use disorder: A systematic review.
Topics: Analgesics, Opioid; Excitatory Amino Acid Antagonists; Humans; Ketamine; Memantine; Methadone; Opiat | 2020 |
Opioids and sleep - a review of literature.
Topics: Analgesics, Opioid; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Slee | 2020 |
Case Report: Buprenorphine Induction Using Transdermal Buprenorphine in a Veteran With Opioid Use Disorder and Psychosis, Managing Precipitated Withdrawal.
Topics: Buprenorphine; Humans; Methadone; Opioid-Related Disorders; Psychotic Disorders; Substance Withdrawa | 2020 |
Psychosis after buprenorphine, heroin, methadone, morphine, oxycodone, and tramadol withdrawal: a systematic review.
Topics: Analgesics, Opioid; Buprenorphine; Heroin; Humans; Methadone; Morphine; Oxycodone; Psychotic Disorde | 2021 |
Opioid Addiction: Social Problems Associated and Implications of Both Current and Possible Future Treatments, including Polymeric Therapeutics for Giving Up the Habit of Opioid Consumption.
Topics: Analgesics, Opioid; Behavior, Addictive; Habits; Humans; Methadone; Opioid-Related Disorders; Substa | 2017 |
Pharmacological therapies for management of opium withdrawal.
Topics: Amantadine; Amines; Baclofen; Buprenorphine; Clonidine; Cyclohexanecarboxylic Acids; Gabapentin; gam | 2018 |
On the addictive power of gabapentinoids: a mini-review.
Topics: Adult; Amines; Animals; Comorbidity; Craving; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobu | 2018 |
Treatment of Perinatal Opioid Use Disorder.
Topics: Adult; Analgesics, Opioid; Decision Making; Female; Humans; Infant, Newborn; Methadone; Neonatal Abs | 2018 |
CE: Acute Pain Management for People with Opioid Use Disorder.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Middle Aged; Naltrexone; Narcotic Anta | 2018 |
Opioid tapering and weaning protocols in pediatric critical care units: a systematic review.
Topics: Analgesics, Opioid; Child; Critical Care; Humans; Intensive Care Units, Pediatric; Methadone; Substa | 2018 |
Methadone at tapered doses for the management of opioid withdrawal.
Topics: Humans; Methadone; Narcotics; Opiate Substitution Treatment; Opioid-Related Disorders; Randomized Co | 2013 |
Alpha2-adrenergic agonists for the management of opioid withdrawal.
Topics: Acute Disease; Adrenergic alpha-2 Receptor Agonists; Controlled Clinical Trials as Topic; Humans; Me | 2014 |
Addiction disorders.
Topics: Alcohol Deterrents; Analgesics, Opioid; Buprenorphine; Cognitive Behavioral Therapy; Comorbidity; Ha | 2014 |
Are Pharmacotherapies Ineffective in Opioid-Dependent Smokers? Reflections on the Scientific Literature and Future Directions.
Topics: Analgesics, Opioid; Bupropion; Forecasting; Humans; Methadone; Opioid-Related Disorders; Randomized | 2015 |
Alpha₂-adrenergic agonists for the management of opioid withdrawal.
Topics: Acute Disease; Adrenergic alpha-2 Receptor Agonists; Clonidine; Controlled Clinical Trials as Topic; | 2016 |
Pharmacotherapy for Substance Use Disorders.
Topics: Age Factors; Alcohol Deterrents; Alcoholism; Antidepressive Agents; Buprenorphine; Bupropion; Drug T | 2016 |
Methadone analgesia in the critically ill.
Topics: Adult; Analgesics, Opioid; Child; Critical Illness; Delirium; Humans; Intensive Care Units; Methadon | 2016 |
Treatment of Opioid-Use Disorders.
Topics: Adrenergic alpha-Agonists; Buprenorphine; Humans; Methadone; Opiate Substitution Treatment; Opioid-R | 2016 |
Caring for patients with opioid use disorder in the hospital.
Topics: Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Dru | 2016 |
Alpha-adrenergic Agonists for the Management of Opioid Withdrawal.
Topics: Adrenergic alpha-2 Receptor Agonists; Controlled Clinical Trials as Topic; Female; Humans; Male; Met | 2017 |
The use of methadone to facilitate opioid weaning in pediatric critical care patients: a systematic review of the literature and meta-analysis.
Topics: Analgesics, Opioid; Child; Critical Care; Humans; Methadone; Pain; Substance Withdrawal Syndrome | 2017 |
Buprenorphine for managing opioid withdrawal.
Topics: Acute Disease; Buprenorphine; Clonidine; Female; Humans; Male; Methadone; Narcotic Antagonists; Opia | 2017 |
A meta-analysis of acupuncture combined with opioid receptor agonists for treatment of opiate-withdrawal symptoms.
Topics: Acupuncture Therapy; Adult; Analgesics, Opioid; Combined Modality Therapy; Humans; Male; Medicine, C | 2009 |
[Methadone treatment and its dangers].
Topics: Adult; Analgesics, Opioid; Child, Preschool; Drug Interactions; Drug Overdose; Electrocardiography; | 2009 |
Opioid dependence treatment: options in pharmacotherapy.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Buprenorphine; Clinical Trials as Topic; Humans; Meth | 2009 |
The pharmacological treatment of opioid addiction--a clinical perspective.
Topics: Adrenergic Agonists; Analgesics, Opioid; Buprenorphine; Clonidine; Drug Therapy, Combination; Humans | 2010 |
Heroin anticraving medications: a systematic review.
Topics: Buprenorphine; Heroin; Heroin Dependence; Humans; Methadone; Naltrexone; Narcotic Antagonists; Narco | 2010 |
Opioid dependence.
Topics: Analgesics, Opioid; Behavior Therapy; Buprenorphine; Cognitive Behavioral Therapy; Humans; Methadone | 2011 |
Intrauterine abstinence syndrome (IAS) during buprenorphine inductions and methadone tapers: can we assure the safety of the fetus?
Topics: Buprenorphine; Epigenesis, Genetic; Female; Fetal Diseases; Humans; Methadone; Narcotics; Pregnancy; | 2012 |
Acute pain management in opioid-tolerant patients: a growing challenge.
Topics: Acute Disease; Analgesics; Analgesics, Opioid; Animals; Australia; Buprenorphine; Buprenorphine, Nal | 2011 |
Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives.
Topics: Biological Availability; Buprenorphine; Chemistry, Pharmaceutical; Humans; Methadone; Naltrexone; Na | 2012 |
Selection of the initial methadone regimen for the management of iatrogenic opioid abstinence syndrome in critically ill children.
Topics: Analgesics, Opioid; Child; Clinical Trials as Topic; Critical Illness; Disease Management; Dose-Resp | 2012 |
Opioid detoxification and naltrexone induction strategies: recommendations for clinical practice.
Topics: Adrenergic alpha-2 Receptor Agonists; Buprenorphine; Clinical Protocols; Clonidine; Drug Administrat | 2012 |
[When and how to detoxify clients from methadone maintenance treatment?].
Topics: Heroin Dependence; Humans; Inactivation, Metabolic; Maintenance Chemotherapy; Methadone; Narcotics; | 2013 |
Maintenance medication for opiate addiction: the foundation of recovery.
Topics: Analgesics, Opioid; Buprenorphine; Humans; Long-Term Care; Methadone; Naltrexone; Narcotic Antagonis | 2012 |
Medications development for opioid abuse.
Topics: Analgesics, Opioid; Buprenorphine; Choice Behavior; Endocannabinoids; Evidence-Based Medicine; Human | 2013 |
Pharmacological maintenance treatments of opiate addiction.
Topics: Buprenorphine; Drug Overdose; Heroin; Heroin Dependence; Humans; Methadone; Opiate Substitution Trea | 2014 |
Management of the hospitalized injection drug user.
Topics: Chronic Disease; Comorbidity; Female; Hospitalization; Humans; Male; Methadone; Pain; Severity of Il | 2002 |
Clinical efficacy of buprenorphine: comparisons to methadone and placebo.
Topics: Buprenorphine; Controlled Clinical Trials as Topic; Humans; Methadone; Narcotic Antagonists; Opioid- | 2003 |
Alpha2 adrenergic agonists for the management of opioid withdrawal.
Topics: Acute Disease; Controlled Clinical Trials as Topic; Humans; Methadone; Narcotics; Randomized Control | 2003 |
Methadone at tapered doses for the management of opioid withdrawal.
Topics: Humans; Methadone; Narcotics; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome | 2003 |
Methadone at tapered doses for the management of opioid withdrawal.
Topics: Humans; Methadone; Narcotics; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome | 2003 |
[Ultrashort withdrawal from opiate dependence].
Topics: Anesthesia; Humans; Methadone; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome | 2003 |
Clinical use of methadone.
Topics: Analgesics, Opioid; Biological Availability; Dosage Forms; Drug Administration Schedule; Drug Intera | 2002 |
Treating opioid dependence. Growing implications for primary care.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Buprenorphine; Europe; Humans; Methadone; Methadyl Acetate | 2004 |
Effectiveness of interventions on opiate withdrawal treatment: an overview of systematic reviews.
Topics: Adrenergic alpha-Agonists; Antidepressive Agents, Tricyclic; Buprenorphine; Humans; Methadone; Narco | 2004 |
Pharmacological treatments for substance use disorders.
Topics: Adrenergic beta-Antagonists; Alcohol Deterrents; Anti-Anxiety Agents; Benzodiazepines; Buprenorphine | 2004 |
Alpha2 adrenergic agonists for the management of opioid withdrawal.
Topics: Acute Disease; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Controlled Clinical | 2004 |
Methadone at tapered doses for the management of opioid withdrawal.
Topics: Humans; Methadone; Narcotics; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Subst | 2004 |
Methadone at tapered doses for the management of opioid withdrawal.
Topics: Humans; Methadone; Narcotics; Opioid-Related Disorders; Randomized Controlled Trials as Topic; Subst | 2005 |
[Benzodiazepine withdrawal in subjects on opiate substitution treatment].
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Heroin Dependence; Humans; Methadone; Narcotics; Substan | 2006 |
Opiate addiction in China: current situation and treatments.
Topics: Buprenorphine; China; Clonidine; Drugs, Chinese Herbal; HIV Infections; Humans; Methadone; Naltrexon | 2006 |
Opioid dependence: rationale for and efficacy of existing and new treatments.
Topics: Buprenorphine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Fe | 2006 |
Treatment of alcohol and other drug dependence.
Topics: Alcoholism; Behavior, Addictive; Comorbidity; Humans; Methadone; Naltrexone; Psychotherapy; Substanc | 2007 |
Methadone and buprenorphine treatment during pregnancy: what are the effects on infants?
Topics: Analgesics, Opioid; Buprenorphine; Female; Fetus; Humans; Infant, Low Birth Weight; Infant, Newborn; | 2007 |
Pharmacologic treatments for opioid dependence: detoxification and maintenance options.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Op | 2007 |
[Narcotic withdrawal syndrome. Therapeutic methods].
Topics: Acupuncture Therapy; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Analgesia; Brain; Centr | 1982 |
[Treatment of opiate withdrawal syndromes (historical review)].
Topics: Antipsychotic Agents; Clonidine; Drug Evaluation; History, 19th Century; History, 20th Century; Huma | 1984 |
Psychological characteristics and development of narcotic-addicted infants.
Topics: Child Behavior Disorders; Developmental Disabilities; Heroin; Humans; Infant, Newborn; Infant, Newbo | 1983 |
Multiple mechanisms of withdrawal from opioid drugs.
Topics: Acetylcholine; Adenine Nucleotides; Animals; Benzodiazepines; Calcium; Calmodulin; Clonidine; Condit | 1984 |
Behavioral effects of prenatal exposure to opiates.
Topics: Age Factors; Animals; Animals, Suckling; Behavior, Animal; Female; Heroin; Humans; Methadone; Mice; | 1983 |
Infants of drug-dependent mothers.
Topics: Abnormalities, Drug-Induced; Female; Fetal Alcohol Spectrum Disorders; Fetal Growth Retardation; Her | 1983 |
Major medical problems and detoxification treatment of parenteral drug-abusing alcoholics.
Topics: Acquired Immunodeficiency Syndrome; Alcoholism; Homosexuality; Humans; Hypnotics and Sedatives; Infe | 1984 |
New insights and treatments: opiate withdrawal and cocaine addiction.
Topics: Brain Chemistry; Clonidine; Cocaine; Dopamine; Humans; Methadone; Naltrexone; Norepinephrine; Substa | 1984 |
Psychotherapeutic treatment of opiate addiction.
Topics: Behavior Therapy; Goals; Humans; Male; Methadone; Opioid-Related Disorders; Psychotherapy; Social Be | 1981 |
Opiate withdrawal.
Topics: Animals; Brain; Conditioning, Classical; Humans; Methadone; Motivation; Naloxone; Narcotic Antagonis | 1994 |
Methadone during pregnancy: the search for a valid animal model.
Topics: Animals; Behavior, Animal; Child; Child, Preschool; Disease Models, Animal; Female; Heroin Dependenc | 1993 |
Common errors in the pharmacologic treatment of drug dependence and withdrawal.
Topics: Behavior Therapy; Buprenorphine; Clonidine; Humans; Lithium; Methadone; Narcotics; Nicotine; Psychot | 1994 |
Opiate detoxification protocols. A clinical manual.
Topics: Administration, Cutaneous; Clinical Protocols; Clonidine; Codeine; Female; Humans; Male; Methadone; | 1993 |
Opiate detoxification protocols. A clinical manual.
Topics: Administration, Cutaneous; Clinical Protocols; Clonidine; Codeine; Female; Humans; Male; Methadone; | 1993 |
Opiate detoxification protocols. A clinical manual.
Topics: Administration, Cutaneous; Clinical Protocols; Clonidine; Codeine; Female; Humans; Male; Methadone; | 1993 |
Opiate detoxification protocols. A clinical manual.
Topics: Administration, Cutaneous; Clinical Protocols; Clonidine; Codeine; Female; Humans; Male; Methadone; | 1993 |
Opiate addiction and the locus coeruleus. The clinical utility of clonidine, naltrexone, methadone, and buprenorphine.
Topics: Animals; Buprenorphine; Clonidine; Humans; Locus Coeruleus; Methadone; Naltrexone; Opioid-Related Di | 1993 |
What is important in drug misuse treatment?
Topics: Buprenorphine; Clonidine; Humans; Methadone; Naltrexone; Narcotic Antagonists; Substance Withdrawal | 1996 |
[Drug addiction--origin, development and pharmacological intervention].
Topics: Acupuncture Therapy; Adaptation, Physiological; Alcoholic Intoxication; Animals; Conditioning, Psych | 1997 |
Alcohol and drug dependence: diagnosis and management.
Topics: Adult; Analgesics, Opioid; Female; Humans; Medical History Taking; Methadone; Models, Psychological; | 1998 |
WHO Expert Committee on Drug Dependence. Thirtieth report.
Topics: Acute Disease; Cost of Illness; Cost-Benefit Analysis; Health Policy; Humans; Methadone; Narcotics; | 1998 |
[Drug-related emergencies with opiates].
Topics: Drug Overdose; Emergencies; Heroin Dependence; Humans; Internal Medicine; Methadone; Narcotics; Opio | 1999 |
[Drug withdrawal therapies].
Topics: Ambulatory Care; Buprenorphine; Combined Modality Therapy; Drug Administration Schedule; Humans; Met | 1999 |
[Drug substitution in heroin dependence with methadone].
Topics: Heroin Dependence; Humans; Life Style; Methadone; Patient Care Team; Social Environment; Substance A | 1999 |
Pharmacologic treatment of heroin-dependent patients.
Topics: Analgesics, Opioid; Buprenorphine; Counseling; Heroin Dependence; Humans; Mental Disorders; Methadon | 2000 |
The physical and psychosocial consequences of opioid addiction: an overview of changes in opioid treatment.
Topics: Humans; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance | 2000 |
Alpha2 adrenergic agonists for the management of opioid withdrawal.
Topics: Acute Disease; Humans; Methadone; Narcotics; Randomized Controlled Trials as Topic; Receptors, Adren | 2001 |
A meta-analysis comparing the effectiveness of buprenorphine and methadone.
Topics: Buprenorphine; Female; Humans; Male; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndr | 2000 |
Opioid tolerance in neonates: a state-of-the-art review.
Topics: Analgesics, Opioid; Child Development; Drug Tolerance; Humans; Infant, Newborn; Methadone; Morphine; | 2001 |
Methadone at tapered doses for the management of opioid withdrawal.
Topics: Humans; Methadone; Narcotics; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome | 2002 |
Alpha2-adrenergic agonists in opioid withdrawal.
Topics: Adrenergic alpha-Agonists; Clonidine; Confidence Intervals; Controlled Clinical Trials as Topic; Hum | 2002 |
Methadone at tapered doses for the management of opioid withdrawal.
Topics: Humans; Methadone; Narcotics; Randomized Controlled Trials as Topic; Substance Withdrawal Syndrome | 2002 |
Rx: 3x/week LAAM: alternative to methadone. Clinical studies: Phase I.
Topics: Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluat | 1976 |
The neonatal narcotic withdrawal syndrome: a therapeutic challenge.
Topics: Barbiturates; Chlorpromazine; Diazepam; Humans; Infant Care; Infant, Newborn; Infant, Newborn, Disea | 1975 |
Methadone maintenance and narcotic blocking drugs. Appendix.
Topics: Administration, Oral; Cyclazocine; Drug Tolerance; Heroin Dependence; Humans; Injections, Subcutaneo | 1977 |
The effect of maternal narcotic addiction on the newborn infant.
Topics: Abnormalities, Drug-Induced; Breast Feeding; Female; Fertility; Heroin Dependence; Humans; Infant Mo | 1977 |
Narcotic analgesics and aggression.
Topics: Aggression; Animals; Behavior, Animal; Electroshock; Humans; Methadone; Morphine; Parasympathomimeti | 1978 |
Detoxification from methadone: results and inferences.
Topics: Heroin Dependence; Humans; Methadone; Substance Withdrawal Syndrome | 1978 |
Introduction. Roc: 3x/week LAAM: alternative to methadone.
Topics: Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Evaluation, Preclinica | 1976 |
Drug interactions with methadone.
Topics: Adult; Aged; Chromatography, Gas; Drug Interactions; Feces; Female; Heroin Dependence; Humans; Liver | 1976 |
[Clonidine-naltrexone: a new technic for the detoxification of opiate addicts].
Topics: Clonidine; Drug Therapy, Combination; Humans; Methadone; Naltrexone; Narcotics; Opioid-Related Disor | 1990 |
Methadone maintenance in the treatment of opioid dependence. A current perspective.
Topics: Acquired Immunodeficiency Syndrome; Attitude of Health Personnel; Cocaine; Drug Interactions; Ethano | 1990 |
Cranial electrostimulation (CES) use in the detoxification of opiate-dependent patients.
Topics: Acupuncture Therapy; Brain; Electric Stimulation; Humans; Methadone; Narcotics; Substance Withdrawal | 1990 |
Clonidine and the treatment of the opiate withdrawal syndrome.
Topics: Clonidine; Humans; Hypotension; Methadone; Naltrexone; Narcotics; Substance Withdrawal Syndrome | 1988 |
The opioid-dependent patient with acute pain.
Topics: Acute Disease; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pain; Pain, Postoperative; Su | 1987 |
Treatment perspectives in drug misuse: the opiate paradigm.
Topics: Endorphins; Female; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Mal | 1987 |
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory.
Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Cloni | 1986 |
Developmental effects of narcotics.
Topics: Analysis of Variance; Animals; Body Weight; Female; Fetal Diseases; Growth; Humans; Methadone; Nalox | 1986 |
Narcotic withdrawal in the emergency department.
Topics: Clonidine; Emergency Service, Hospital; Endorphins; Humans; Methadone; Narcotics; Nervous System Dis | 1985 |
The neonatal narcotic abstinence syndrome: a brief review.
Topics: Chlorpromazine; Diazepam; Female; Humans; Infant, Newborn; Methadone; Narcotics; Opium; Phenobarbita | 1985 |
Interactions of narcotic antagonists with receptor sites.
Topics: Acetylcholine; Animals; Atropine; Binding Sites; Brain; Chromatography; Drug Tolerance; Electric Sti | 1973 |
Methadone and naloxone in combination (Naldone) for the treatment of heroin addicts.
Topics: Administration, Oral; Animals; Biological Availability; Dosage Forms; Dose-Response Relationship, Dr | 1973 |
Advances in the treatment of drug addiction.
Topics: Alcoholism; Amphetamine; Aversive Therapy; Barbiturates; Heroin; Humans; Lysergic Acid Diethylamide; | 1972 |
Methadone treatment of heroin addiction.
Topics: Dose-Response Relationship, Drug; Humans; Methadone; Substance Withdrawal Syndrome; Substance-Relate | 1973 |
Methadone.
Topics: Acetates; Administration, Oral; Adolescent; American Medical Association; Canada; Chemical Phenomena | 1973 |
Narcotic poisoning: a review of the literature.
Topics: Chemical and Drug Induced Liver Injury; Drug Contamination; Endocarditis; Heroin Dependence; Humans; | 1974 |
Effects of narcotics and narcotic antagonists on operant behavior.
Topics: Animals; Avoidance Learning; Behavior, Animal; Chlorpromazine; Columbidae; Conditioning, Operant; Cy | 1973 |
Narcotic poisoning of children (1) through accidental ingestion of methadone and (2) in utero.
Topics: Administration, Oral; Apgar Score; Birth Weight; Child; Child Care; Female; Gestational Age; Heroin | 1974 |
196 trials available for methadone and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Hyperbaric Oxygen Therapy for Pain, Opioid Withdrawal, and Related Symptoms: A Pilot Randomized Controlled Trial.
Topics: Adult; Analgesics, Opioid; Humans; Hyperbaric Oxygenation; Methadone; Opioid-Related Disorders; Oxyg | 2022 |
The effect of a methadone-initiated memory reconsolidation updating procedure in opioid use disorder: A translational study.
Topics: Animals; Heroin; Humans; Male; Methadone; Narcotics; Neoplasm Recurrence, Local; Opioid-Related Diso | 2022 |
Differential effect of cannabis use on opioid agonist treatment outcomes: Exploratory analyses from the OPTIMA study.
Topics: Analgesics, Opioid; Bayes Theorem; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cannabis | 2023 |
Adjuvant laser meridian massage in men with opioid use disorder on methadone maintenance treatment: Protocol for a case-controlled study.
Topics: Acupuncture Points; Adult; Analgesics, Opioid; Case-Control Studies; Humans; Lasers; Male; Massage; | 2019 |
The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment.
Topics: Adult; Analgesics, Opioid; Carotenoids; Cognition; Craving; Female; Humans; Male; Methadone; Substan | 2021 |
Lorcaserin treatment for extended-release naltrexone induction and retention for opioid use disorder individuals: A pilot, placebo-controlled randomized trial.
Topics: Adult; Animals; Benzazepines; Buprenorphine; Delayed-Action Preparations; Female; Humans; Injections | 2021 |
Comparing the effect of buprenorphine and methadone in the reduction of methamphetamine craving: a randomized clinical trial.
Topics: Adult; Amphetamine-Related Disorders; Analgesics, Opioid; Behavior, Addictive; Buprenorphine; Centra | 2017 |
Buprenorphine/naloxone versus methadone and lofexidine in community stabilisation and detoxification: A randomised controlled trial of low dose short-term opiate-dependent individuals.
Topics: Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Clonidine; Craving; Double-Blind Metho | 2017 |
A randomized, open label trial of methadone continuation versus forced withdrawal in a combined US prison and jail: Findings at 12 months post-release.
Topics: Adult; Analgesics, Opioid; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Op | 2018 |
Opioid-like effects of the neurokinin 1 antagonist aprepitant in patients maintained on and briefly withdrawn from methadone.
Topics: Adult; Antiemetics; Aprepitant; Behavior, Addictive; Cross-Over Studies; Double-Blind Method; Drug I | 2013 |
Pharmacokinetic interaction between telaprevir and methadone.
Topics: Adolescent; Adult; Antiviral Agents; Area Under Curve; Drug Interactions; Female; Humans; Male; Meth | 2013 |
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual | 2013 |
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual | 2013 |
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual | 2013 |
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual | 2013 |
Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure.
Topics: Adult; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Dose-Response Relationship, Dr | 2013 |
Dolutegravir does not affect methadone pharmacokinetics in opioid-dependent, HIV-seronegative subjects.
Topics: Adolescent; Adult; Aged; Drug Interactions; Female; Heterocyclic Compounds, 3-Ring; HIV Integrase In | 2013 |
The effects of gabapentin on methadone based addiction treatment: a randomized controlled trial.
Topics: Adult; Amines; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Therapy, C | 2013 |
The effect of rilpivirine on the pharmacokinetics of methadone in HIV-negative volunteers.
Topics: Adolescent; Adult; Analgesics, Opioid; Anti-HIV Agents; Drug Interactions; Drug Therapy, Combination | 2014 |
The association of genetic polymorphisms in the κ-opioid receptor 1 gene with body weight, alcohol use, and withdrawal symptoms in patients with methadone maintenance.
Topics: Adolescent; Adult; Alcohol Drinking; Body Weight; Genetic Association Studies; Haplotypes; Heroin De | 2014 |
Effect of steady-state faldaprevir on the pharmacokinetics of steady-state methadone and buprenorphine-naloxone in subjects receiving stable addiction management therapy.
Topics: Administration, Oral; Adult; Aminoisobutyric Acids; Buprenorphine; Buprenorphine, Naloxone Drug Comb | 2015 |
Self-reported cravings for heroin and cocaine during maintenance treatment with slow-release oral morphine compared with methadone: a randomized, crossover clinical trial.
Topics: Adult; Cocaine-Related Disorders; Cross-Over Studies; Female; Heroin Dependence; Humans; Male; Metha | 2015 |
No evidence for reduction of opioid-withdrawal symptoms by cannabis smoking during a methadone dose taper.
Topics: Adult; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Drug Therapy, Combination; Femal | 2015 |
Opium tincture versus methadone syrup in management of acute raw opium withdrawal: A randomized, double-blind, controlled trial.
Topics: Adolescent; Adult; Dosage Forms; Double-Blind Method; Humans; Male; Methadone; Middle Aged; Narcotic | 2016 |
Pilot trial of gabapentin for the treatment of benzodiazepine abuse or dependence in methadone maintenance patients.
Topics: Adolescent; Adult; Aged; Amines; Benzodiazepines; Combined Modality Therapy; Cyclohexanecarboxylic A | 2016 |
Ascending Single-Dose, Double-Blind, Placebo-Controlled Safety Study of Noribogaine in Opioid-Dependent Patients.
Topics: Adult; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; | 2016 |
The effect of stress on craving for methadone depends on the timing of last methadone dose.
Topics: Behavior, Addictive; Cold Temperature; Female; Heroin Dependence; Humans; Male; Methadone; Middle Ag | 2008 |
Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial.
Topics: Adult; Analgesics, Opioid; Community Mental Health Services; Disruptive, Impulse Control, and Conduc | 2009 |
Auricular acupuncture as an adjunct to opiate detoxification treatment: effects on withdrawal symptoms.
Topics: Acupuncture, Ear; Adult; Female; Humans; Male; Methadone; Narcotics; Opioid-Related Disorders; Patie | 2009 |
Cognitive functioning during methadone and buprenorphine treatment: results of a randomized clinical trial.
Topics: Analgesics, Opioid; Attention; Buprenorphine; Cognition; Humans; Memory; Methadone; Neuropsychologic | 2008 |
A randomized effectiveness trial of methadone, TENS and methadone plus TENS in management of opiate withdrawal symptoms.
Topics: Analgesics, Opioid; Analysis of Variance; Combined Modality Therapy; Humans; Male; Methadone; Opioid | 2008 |
Intensity of opiate withdrawal in relation to the 825C>T polymorphism of the G-protein beta 3 subunit gene.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Antihypertensive Agents; Blood Pressure; Clonidine; | 2009 |
Methadone-nicotine interactions in methadone maintenance treatment patients.
Topics: Adult; Double-Blind Method; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Narcoti | 2009 |
The acceptability, safety, and tolerability of methadone/naloxone in a 50:1 ratio.
Topics: Adult; Aged; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Heroin Dependence; | 2009 |
A double-blind, randomized, parallel group study to compare the efficacy, safety and tolerability of slow-release oral morphine versus methadone in opioid-dependent in-patients willing to undergo detoxification.
Topics: Adult; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Male; Methadone; Morphine; | 2009 |
Outpatient versus inpatient opioid detoxification: a randomized controlled trial.
Topics: Analgesics, Opioid; Clonidine; Female; Heroin; Heroin Dependence; Humans; Inpatients; Male; Methadon | 2011 |
A trial of methadone tapering schedules in pediatric intensive care unit patients exposed to prolonged sedative infusions.
Topics: Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedul | 2011 |
Concurrent alcohol dependence among methadone-maintained cocaine abusers is associated with greater abstinence.
Topics: Adult; Alcohol-Related Disorders; Cocaine-Related Disorders; Female; Follow-Up Studies; Humans; Male | 2011 |
Problem drinking and low-dose naltrexone-assisted opioid detoxification.
Topics: Adult; Alcohol Drinking; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Methadone; Na | 2011 |
Importance of gabapentin dose in treatment of opioid withdrawal.
Topics: Adult; Amines; Analgesics, Opioid; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relat | 2011 |
The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Clonidine; Disease Management; Dose-Respons | 2012 |
A stage I pilot study of acceptance and commitment therapy for methadone detoxification.
Topics: Adult; Counseling; Diagnostic and Statistical Manual of Mental Disorders; Fear; Female; Humans; Inac | 2012 |
Tramadol versus methadone for treatment of opiate withdrawal: a double-blind, randomized, clinical trial.
Topics: Adolescent; Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Double-Blind Method; Heroin | 2012 |
Ultrarapid high-dose methadone detoxification.
Topics: Adult; Dose-Response Relationship, Drug; Humans; Inactivation, Metabolic; Intubation, Intratracheal; | 2003 |
Neuropsychological correlates of opioid dependence and withdrawal.
Topics: Adolescent; Adult; Cognition Disorders; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Neu | 2003 |
Opioid detoxification with buprenorphine, clonidine, or methadone in hospitalized heroin-dependent patients with HIV infection.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adult; Buprenorphine; Clonidine; Dose-Response Rela | 2003 |
Cessation of methadone maintenance treatment using buprenorphine: transfer from methadone to buprenorphine and subsequent buprenorphine reductions.
Topics: Adult; Buprenorphine; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Methado | 2003 |
Rapid detoxification from opioid dependence under general anaesthesia versus standard methadone tapering: abstinence rates and withdrawal distress experiences.
Topics: Adolescent; Adult; Anesthesia, General; Female; Heroin; Heroin Dependence; Humans; Inactivation, Met | 2003 |
[Is premature termination of opiate detoxification due to intensive withdrawal or craving?].
Topics: Adolescent; Adult; Analgesics, Opioid; Female; Heroin Dependence; Humans; Male; Methadone; Middle Ag | 2004 |
Use of gabapentin for attenuation of symptoms following rapid opiate detoxification (ROD)--correlation with neurophysiological parameters--.
Topics: Acetates; Adult; Amines; Anesthesia; Anesthetics, Intravenous; Cyclohexanecarboxylic Acids; Electric | 2004 |
Evaluation of levo-alpha-acetylmethdol (LAAM) as an alternative treatment for methadone maintenance patients who regularly experience withdrawal: a pharmacokinetic and pharmacodynamic analysis.
Topics: Adult; Analysis of Variance; Cross-Over Studies; Female; Humans; Male; Methadone; Methadyl Acetate; | 2004 |
Comparison of tincture of opium and methadone to control opioid withdrawal in a Thai treatment centre.
Topics: Administration, Oral; Adult; Humans; Methadone; Middle Aged; Morphine; Narcotics; Opioid-Related Dis | 2004 |
Opioid craving and seeking behavior in physically dependent volunteers: effects of acute withdrawal and drug reinforcement opportunity.
Topics: Adult; Conditioning, Operant; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fentany | 2005 |
Randomized controlled study transitioning opioid-dependent pregnant women from short-acting morphine to buprenorphine or methadone.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Humans; Methadone; Morphine; Opioid-Related Disor | 2005 |
A new approach to preventing relapse in opiate addicts: a psychometric evaluation.
Topics: Administration, Oral; Adult; Affect; Delayed-Action Preparations; Drug Administration Schedule; Fema | 2006 |
Methadone doses of 100 mg or greater are more effective than lower doses at suppressing heroin self-administration in opioid-dependent volunteers.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Double-Blind Method; Heroin Dependence; | 2005 |
Opioid plasma concentrations in methadone-and buprenorphine-maintained patients.
Topics: Administration, Oral; Administration, Sublingual; Adolescent; Adult; Buprenorphine; Dose-Response Re | 2005 |
Early impact of methadone induction for heroin dependence: differential effects of two dose sequences in a randomized controlled study.
Topics: Adult; Affect; Female; Heroin Dependence; Humans; Logistic Models; Male; Methadone; Middle Aged; Sub | 2006 |
Relationship between plasma cortisol levels, withdrawal symptoms and craving in abstinent and treated heroin addicts.
Topics: Adult; Buprenorphine; Female; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Hydrocortisone; | 2006 |
Stereoselective quantification of methadone and a d(6)-labeled isotopomer using high performance liquid chromatography-atmospheric pressure chemical ionization mass-spectrometry: application to a pharmacokinetic study in a methadone maintained subject.
Topics: Administration, Oral; Adult; Area Under Curve; Atmospheric Pressure; Chromatography, High Pressure L | 2006 |
A randomized controlled trial of the therapeutic workplace for community methadone patients: a partial failure to engage.
Topics: Adolescent; Adult; Baltimore; Female; Humans; Male; Methadone; Sheltered Workshops; Substance Withdr | 2006 |
In-patient detoxification procedures, treatment retention, and post-treatment opiate use: comparison of lofexidine + naloxone, lofexidine + placebo, and methadone.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analgesics, Opioid; Clonidine; Cohort Studies; Double- | 2007 |
Composition of EEG oscillations and their temporal characteristics: methadone treatment.
Topics: Adult; Brain; Cortical Synchronization; Electroencephalography; Female; Humans; Male; Methadone; Nar | 2007 |
Effects of pegylated interferon alfa-2b on the pharmacokinetic and pharmacodynamic properties of methadone: a prospective, nonrandomized, crossover study in patients coinfected with hepatitis C and HIV receiving methadone maintenance treatment.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Antiviral Agents; Area Under Curve; Cross-Over Stud | 2007 |
Comparison of buprenorphine and methadone in the treatment of opiate withdrawal: possible advantages of buprenorphine for the treatment of opiate-benzodiazepine codependent patients?
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Buprenorphine; Diazepam; Female; Humans; Male; Methadon | 2007 |
Methadone dosing strategies in HIV-infected injection drug users enrolled in a directly observed therapy program.
Topics: Administration, Oral; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; | 2007 |
Sublingual buprenorphine/naloxone precipitated withdrawal in subjects maintained on 100mg of daily methadone.
Topics: Administration, Sublingual; Adult; Buprenorphine; Cognition Disorders; Double-Blind Method; Drug Com | 2007 |
Hemodynamic and cognitive effects of lofexidine and methadone coadministration: a pilot study.
Topics: Adolescent; Adult; Blood Pressure; Clonidine; Cognition; Dose-Response Relationship, Drug; Double-Bl | 2007 |
Melatonin for perceived sleep disturbances associated with benzodiazepine withdrawal among patients in methadone maintenance treatment: a double-blind randomized clinical trial.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Central Nervous System Depressants; Circad | 2007 |
PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users.
Topics: Adult; Anxiety; Caudate Nucleus; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Hero | 2008 |
Retention rate and substance use in methadone and buprenorphine maintenance therapy and predictors of outcome: results from a randomized study.
Topics: Adult; Analysis of Variance; Buprenorphine; Chi-Square Distribution; Double-Blind Method; Female; Hu | 2008 |
Propoxyphene form maintenance treatment of narcotic addiction.
Topics: Adult; Dextropropoxyphene; Humans; Methadone; Middle Aged; Opioid-Related Disorders; Substance Withd | 1981 |
Propoxyphene napsylate compared to methadone for opiate dependence.
Topics: Adult; Dextropropoxyphene; Electrocardiography; Electroencephalography; Humans; Male; Methadone; Opi | 1981 |
Clinical utility of clonidine in opiate withdrawal: a study of 100 patients.
Topics: Blood Pressure; Clinical Trials as Topic; Clonidine; Humans; Methadone; Naloxone; Norepinephrine; Op | 1981 |
Methadyl acetate (LAAM) in the treatment of heroin addicts. II. Double-blind comparison of gradual and abrupt detoxification.
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedul | 1983 |
Opiate withdrawal using lofexidine, a clonidine analogue with fewer side effects.
Topics: Adult; Ambulatory Care; Antihypertensive Agents; Clinical Trials as Topic; Clonidine; Humans; Male; | 1983 |
Alternative induction and crossover schedules for methadyl acetate.
Topics: Adolescent; Adult; Attitude to Health; Clinical Trials as Topic; Double-Blind Method; Drug Administr | 1984 |
Methadone dose decreases and anxiety reduction.
Topics: Adult; Anxiety; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Male; Methadone; Opioi | 1984 |
Neonatal methadone withdrawal. Effect of two treatment regimens.
Topics: Blood Pressure; Carbon Dioxide; Drug Administration Schedule; Female; Humans; Hydrogen-Ion Concentra | 1983 |
Naltrexone precipitated opiate withdrawal in methadone addicted human subjects: evidence for noradrenergic hyperactivity.
Topics: Adult; Blood Pressure; Brain; Female; Humans; Kinetics; Male; Methadone; Methoxyhydroxyphenylglycol; | 1984 |
Insomnia among addicts during supervised withdrawal from opiates: a comparison of oral methadone and electrostimulation.
Topics: Adult; Arousal; Electric Stimulation Therapy; Female; Humans; Male; Methadone; Opioid-Related Disord | 1984 |
Administration of meptazinol to opiate-dependent patients.
Topics: Adolescent; Adult; Azepines; Double-Blind Method; Female; Humans; Male; Meptazinol; Methadone; Opioi | 1983 |
Acupuncture in methadone withdrawal.
Topics: Acupuncture Therapy; Adult; Clinical Trials as Topic; Humans; Illicit Drugs; Male; Methadone; Motiva | 1980 |
Short-term detoxification with methadone.
Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Hero | 1981 |
Withdrawal from heroin in three or six weeks. Comparison of methadyl acetate and methadone.
Topics: Adult; Ambulatory Care; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Methadyl Acet | 1982 |
Initial methadone dose in treating opiate addiction.
Topics: Dose-Response Relationship, Drug; Double-Blind Method; Humans; Methadone; Naloxone; Narcotics; Opioi | 1982 |
Clonidine and naltrexone. A safe, effective, and rapid treatment of abrupt withdrawal from methadone therapy.
Topics: Adult; Blood Pressure; Clonidine; Double-Blind Method; Drug Administration Schedule; Female; Heart R | 1982 |
The clinical use of clonidine in abrupt withdrawal from methadone. Effects on blood pressure and specific signs and symptoms.
Topics: Adult; Blood Pressure; Clonidine; Female; Heart Rate; Humans; Male; Methadone; Substance Withdrawal | 1981 |
Intravenous infusion of beta-endorphin increases serum prolactin, but not growth hormone or cortisol, in depressed subjects and withdrawing methadone addicts.
Topics: Adult; Depression; Double-Blind Method; Endorphins; Female; Growth Hormone; Humans; Hydrocortisone; | 1980 |
A cooperative clinical study of methadyl acetate. II. Friday-only regimen.
Topics: Adult; Drug Administration Schedule; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; O | 1980 |
Precipitated withdrawal by pentazocine in methadone-maintained volunteers.
Topics: Adult; Behavior; Humans; Hydromorphone; Male; Methadone; Naloxone; Pentazocine; Psychomotor Performa | 1993 |
Investigating the influence of treatment philosophy on outcome of methadone maintenance.
Topics: Adult; Aftercare; Cohort Studies; Dose-Response Relationship, Drug; Female; Heroin Dependence; Human | 1995 |
Effects of buprenorphine and methadone in methadone-maintained subjects.
Topics: Administration, Oral; Adult; Buprenorphine; Dose-Response Relationship, Drug; Humans; Male; Methadon | 1995 |
Neurobehavioral treatment for cocaine-using methadone patients: a preliminary report.
Topics: Adult; Ambulatory Care; Cocaine; Cognitive Behavioral Therapy; Combined Modality Therapy; Comorbidit | 1994 |
Methadone dosing and pregnancy: impact on program compliance.
Topics: Ambulatory Care; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hu | 1995 |
Opiate dependence and withdrawal: preliminary assessment using single photon emission computerized tomography (SPECT).
Topics: Adult; Analysis of Variance; Basal Ganglia; Blood Pressure; Brain; Cerebral Cortex; Double-Blind Met | 1995 |
Reduction of opiate withdrawal-like symptoms by cocaine abuse during methadone and buprenorphine maintenance.
Topics: Adult; Buprenorphine; Cocaine; Comorbidity; Dose-Response Relationship, Drug; Double-Blind Method; D | 1994 |
Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Clonidine; Dose-Response Relationship, Drug; Double-Blind | 1994 |
Gamma-hydroxybutyric acid for treatment of opiate withdrawal syndrome.
Topics: Adult; Double-Blind Method; Heroin Dependence; Humans; Male; Methadone; Naloxone; Sodium Oxybate; Su | 1993 |
Assessment of nalmefene glucuronide as a selective gut opioid antagonist.
Topics: Adult; Arousal; Autonomic Nervous System; Constipation; Dose-Response Relationship, Drug; Gastrointe | 1995 |
Amantadine does not reduce cocaine use or craving in cocaine-dependent methadone maintenance patients.
Topics: Adult; Amantadine; Cocaine; Dopamine Agonists; Dose-Response Relationship, Drug; Double-Blind Method | 1995 |
Craving and drug reward: a comparison of methadone and clonidine in detoxifying opiate addicts.
Topics: Adrenergic alpha-Agonists; Behavior Therapy; Clonidine; Combined Modality Therapy; Dose-Response Rel | 1995 |
Effects of methadone or buprenorphine maintenance on the subjective and reinforcing effects of intravenous cocaine in humans.
Topics: Adult; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intraven | 1996 |
Buprenorphine versus methadone in the treatment of opioid dependence: self-reports, urinalysis, and addiction severity index.
Topics: Adolescent; Adult; Alcoholism; Buprenorphine; Cocaine; Double-Blind Method; Female; Heroin Dependenc | 1996 |
Randomised double-blind comparison of lofexidine and methadone in the in-patient treatment of opiate withdrawal.
Topics: Adolescent; Adult; Blood Pressure; Clonidine; Double-Blind Method; Female; Heroin Dependence; Humans | 1996 |
Opiate withdrawal with dextromethorphan.
Topics: Adult; Aged; Dextromethorphan; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Patient Sati | 1997 |
A protocol to switch high-dose, methadone-maintained subjects to buprenorphine.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Buprenorphine; Clonidine; Cocaine; Drug Administration Schedule | 1997 |
Dose dependent effects of yohimbine on methadone maintained patients.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Dose-Response Relationship, Drug; Double- | 1997 |
Buprenorphine and naloxone interactions in methadone maintenance patients.
Topics: Adult; Buprenorphine; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Methadone; | 1997 |
Formulation and stability of naltrexone oral liquid for rapid withdrawal from methadone.
Topics: Administration, Oral; Adult; Drug Compounding; Drug Stability; Female; Humans; Male; Methadone; Nalt | 1997 |
Effects of nicotine on methadone self-administration in humans.
Topics: Adult; Analysis of Variance; Behavior, Addictive; Carbon Monoxide; Drug Interactions; Female; Heroin | 1998 |
Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Clonidine; Dose-Response Relationship, Drug; D | 1998 |
Randomised double-blind comparison of lofexidine and clonidine in the out-patient treatment of opiate withdrawal.
Topics: Adrenergic alpha-Agonists; Adult; Ambulatory Care; Blood Pressure; Chi-Square Distribution; Clonidin | 1998 |
Alternative strategies of opiate detoxification: evaluation of the so-called ultra-rapid detoxification.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Anesthesia; Clonidine; Female; Humans; Male; Methadone | 1998 |
Opiate detoxification under anesthesia: no apparent benefit but suppression of thyroid hormones and risk of pulmonary and renal failure.
Topics: Acute Kidney Injury; Adult; Anesthesia; Codeine; Female; Heroin Dependence; Humans; Male; Methadone; | 1999 |
Relative potency of levo-alpha-acetylmethadol and methadone in humans under acute dosing conditions.
Topics: Adult; Analgesics, Opioid; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Heroin Depen | 1999 |
Oral and intravenous methadone use: some clinical and pharmacokinetic aspects.
Topics: Administration, Oral; Adult; Brief Psychiatric Rating Scale; Depressive Disorder; Dose-Response Rela | 1999 |
A pilot study of naltrexone-accelerated detoxification in opioid dependence.
Topics: Adolescent; Adult; Analgesics; Anti-Anxiety Agents; Clonidine; Conscious Sedation; Female; Flunitraz | 1999 |
Three oral formulations of methadone. A clinical and pharmacodynamic comparison.
Topics: Adult; Chemistry, Pharmaceutical; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind | 1999 |
Methylnaltrexone for reversal of constipation due to chronic methadone use: a randomized controlled trial.
Topics: Adult; Analgesics, Opioid; Constipation; Double-Blind Method; Female; Gastrointestinal Transit; Huma | 2000 |
Rapid opiate detoxication in outpatient treatment: relationship with naltrexone compliance.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Anti-Inflammatory Agents, Non-Steroidal; Baclofen; Clo | 2000 |
Acute detoxification of opioid-addicted patients with naloxone during propofol or methohexital anesthesia: a comparison of withdrawal symptoms, neuroendocrine, metabolic, and cardiovascular patterns.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Catecholamines; Female; Humans; Male; Methadon | 2000 |
Combined use of trazodone-naltrexone versus clonidine-naltrexone in rapid withdrawal from methadone treatment. A comparative inpatient study.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analysis of Variance; Clonidine; Drug Therapy, Combina | 2000 |
Naltrexone and lofexidine combination treatment compared with conventional lofexidine treatment for in-patient opiate detoxification.
Topics: Adult; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Dr | 2000 |
The relationship between mood state and plasma methadone concentration in maintenance patients.
Topics: Adult; Affect; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Diso | 2001 |
The pharmacokinetics of methadone in HIV-positive patients receiving the non-nucleoside reverse transcriptase inhibitor efavirenz.
Topics: Adult; Alkynes; Analgesics, Opioid; Benzoxazines; Cyclopropanes; Drug Interactions; Female; HIV Infe | 2001 |
Methadone tapering plus amantadine to detoxify heroin-dependent inpatients with or without an active cocaine use disorder: two randomised controlled trials.
Topics: Adolescent; Adult; Amantadine; Cocaine-Related Disorders; Comorbidity; Dose-Response Relationship, D | 2001 |
Heroin craving and drug use in opioid-maintained volunteers: effects of methadone dose variations.
Topics: Adult; Biological Availability; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; | 2002 |
Absence of opioid withdrawal symptoms in patients receiving methadone and the protease inhibitor lopinavir-ritonavir.
Topics: Adult; Analgesics, Opioid; Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Human | 2002 |
Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients.
Topics: Adrenergic alpha-Antagonists; Adult; Analgesics, Opioid; Anxiety; Blood Pressure; Double-Blind Metho | 2002 |
24-Hour opiate detoxification and antagonist induction at home--the 'Asturian method': a report on 1368 procedures.
Topics: Administration, Oral; Adult; Aftercare; Anti-Anxiety Agents; Benzodiazepines; Clonidine; Drug Implan | 2002 |
Prison based detoxification for opioid dependence: a randomised double blind controlled trial of lofexidine and methadone.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Clonidine; Double-Blind Method; Humans; Male; | 2002 |
Rx: 3x/week LAAM: alternative to methadone. Clinical studies: Phase I.
Topics: Analgesics; Analgesics, Opioid; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluat | 1976 |
Clonidine blocks acute opiate-withdrawal symptoms.
Topics: Acute Disease; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug Evaluation; Follow-Up | 1978 |
Early clinical studies of levo-alpha acetylmethadol (LAAM): an opiate for use in the medical treatment of chronic heroin dependence.
Topics: Arousal; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Admin | 1978 |
Urinary cyclic AMP excretion by methadone subjects during gradual and acute withdrawal.
Topics: Adult; Cyclic AMP; Heroin Dependence; Humans; Methadone; Substance Withdrawal Syndrome | 1977 |
Human pharmacology and abuse potential of the analgesic buprenorphine: a potential agent for treating narcotic addiction.
Topics: Adult; Blood Pressure; Buprenorphine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Do | 1978 |
Methadyl acetate and methadone. An open comparison.
Topics: Adult; Clinical Trials as Topic; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middl | 1977 |
Detoxification from methadone maintenance: double-blind comparison of two methods.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Methadone; Substance Wit | 1978 |
Noradrenergic hyperactivity in opiate withdrawal supported by clonidine reversal of opiate withdrawal.
Topics: Clinical Trials as Topic; Clonidine; Double-Blind Method; Heroin Dependence; Humans; Locus Coeruleus | 1979 |
Introduction. Roc: 3x/week LAAM: alternative to methadone.
Topics: Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Evaluation, Preclinica | 1976 |
Phase III clinical study of levo-alpha-acetylmethadol.
Topics: Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Emotions; Female; Follow-Up Studies; H | 1976 |
Heroin detoxification. A comparison of propoxyphene and methadone.
Topics: Adolescent; Adult; Community Health Services; Dextropropoxyphene; Drug Evaluation; Heroin Dependence | 1975 |
Withdrawal from methadone maintenance. Rate of withdrawal and expectation.
Topics: Adult; Drug Administration Schedule; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Met | 1977 |
Letter: Naloxone for diagnosis in methadone programs.
Topics: Clinical Trials as Topic; Heroin Dependence; Humans; Methadone; Naloxone; Personality Inventory; Sub | 1975 |
Propranolol in the treatment of opiate dependence -- a controlled study.
Topics: Adolescent; Adult; Clinical Trials as Topic; Euphoria; Female; Heart Rate; Humans; Male; Methadone; | 1975 |
[A French experience with methadone].
Topics: Administration, Oral; Adult; Ambulatory Care; Clinical Trials as Topic; Drug Tolerance; Female; Huma | 1975 |
Double-blind detoxification of methadone maintenance patients.
Topics: Administration, Oral; Adult; Consumer Behavior; Heroin Dependence; Humans; Methadone; Middle Aged; P | 1975 |
Assessment and management of opioid withdrawal symptoms in buprenorphine-dependent subjects.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Heroin Dependence; Humans; Male; Methadone; Neuro | 1992 |
Treatment of cocaine dependence in methadone maintenance clients: a pilot study comparing the efficacy of desipramine and amantadine.
Topics: Adolescent; Adult; Amantadine; Baltimore; Cocaine; Desipramine; Female; Follow-Up Studies; Humans; M | 1992 |
The dysphoria of heroin addiction.
Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Mood Disorders; | 1992 |
Phase II clinical trials of buprenorphine: detoxification and induction onto naltrexone.
Topics: Adult; Blood Pressure; Buprenorphine; Double-Blind Method; Female; Humans; Male; Methadone; Methoxyh | 1992 |
A randomized double-blind study of neuroelectric therapy in opiate and cocaine detoxification.
Topics: Adult; Cocaine; Double-Blind Method; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; | 1992 |
The calcium channel antagonist nifedipine causes confusion when used to treat opiate withdrawal in morphine-dependent patients.
Topics: Adult; Clonidine; Confusion; Double-Blind Method; Humans; Male; Methadone; Morphine Dependence; Nife | 1992 |
Hypercortisolism after opioid discontinuation in rapid detoxification of heroin addicts.
Topics: Adult; Circadian Rhythm; Clonidine; Double-Blind Method; Guanfacine; Heroin; Heroin Dependence; Huma | 1992 |
Calcitonin nasal spray reduces opioid withdrawal syndrome without modification of endogenous opioid secretion.
Topics: Administration, Intranasal; Adolescent; Adult; Calcitonin; Endorphins; Female; Humans; Male; Methado | 1992 |
Acute physical dependence in humans: repeated naloxone-precipitated withdrawal after a single dose of methadone.
Topics: Adult; Arousal; Humans; Male; Methadone; Middle Aged; Naloxone; Neurologic Examination; Opioid-Relat | 1991 |
Time course of naloxone-precipitated withdrawal after acute methadone exposure in humans.
Topics: Adult; Arousal; Humans; Injections, Intramuscular; Male; Metabolic Clearance Rate; Methadone; Naloxo | 1991 |
Clinical characteristics of naloxone-precipitated withdrawal in human opioid-dependent subjects.
Topics: Adult; Blood Pressure; Body Temperature; Cognition; Dose-Response Relationship, Drug; Humans; Infusi | 1992 |
Treatment of heroin addicts using buprenorphine.
Topics: Adult; Buprenorphine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heroin | 1991 |
Levels of opioid physical dependence in heroin addicts.
Topics: Adult; Drug Tolerance; Heroin; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Naloxone; Ne | 1991 |
Should opiate addicts be involved in controlling their own detoxification? A comparison of fixed versus negotiable schedules.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methado | 1991 |
Efficacy of clonidine, guanfacine and methadone in the rapid detoxification of heroin addicts: a controlled clinical trial.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Female; Guanfacine; Guanidines; Heroin Dependence; Huma | 1990 |
Comparison of linear versus inverse exponential methadone reduction curves in the detoxification of opiate addicts.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; | 1990 |
Cranial electrostimulation (CES) use in the detoxification of opiate-dependent patients.
Topics: Acupuncture Therapy; Brain; Electric Stimulation; Humans; Methadone; Narcotics; Substance Withdrawal | 1990 |
Comparison of oral preparations of heroin and methadone to stabilise opiate misusers as inpatients.
Topics: Administration, Oral; Adult; Double-Blind Method; Heroin; Humans; Methadone; Opioid-Related Disorder | 1990 |
Opioid antagonist challenges in buprenorphine maintained patients.
Topics: Administration, Sublingual; Adult; Buprenorphine; Dose-Response Relationship, Drug; Drug Therapy, Co | 1990 |
A clinical trial of buprenorphine: I. Comparison with methadone in the detoxification of heroin addicts. II. Examination of its opioid blocking properties.
Topics: Adult; Analysis of Variance; Buprenorphine; Clinical Trials as Topic; Heroin Dependence; Humans; Hyd | 1987 |
Butorphanol-precipitated withdrawal in opioid-dependent human volunteers.
Topics: Adult; Butorphanol; Cognition; Double-Blind Method; Humans; Hydromorphone; Injections, Intramuscular | 1988 |
Antagonist effects of nalbuphine in opioid-dependent human volunteers.
Topics: Adult; Dose-Response Relationship, Drug; Humans; Hydromorphone; Male; Methadone; Morphinans; Nalbuph | 1989 |
Chlordiazepoxide vs. methadone in opiate withdrawal: a preliminary double blind trial.
Topics: Adult; Chlordiazepoxide; Clinical Trials as Topic; Double-Blind Method; Female; Heroin Dependence; H | 1989 |
The Bethlem Study on NET: putting the record straight.
Topics: Clinical Trials as Topic; Double-Blind Method; Electric Stimulation Therapy; Humans; Methadone; Opio | 1989 |
How should opiate withdrawal be measured?
Topics: Arousal; Chlordiazepoxide; Clinical Trials as Topic; Double-Blind Method; Humans; Methadone; Nursing | 1989 |
Opiate withdrawal symptoms in response to 10-day and 21-day methadone withdrawal programmes.
Topics: Adult; Female; Heroin Dependence; Humans; Male; Methadone; Opioid-Related Disorders; Psychiatric Dep | 1989 |
A pilot study of a Neuro-Stimulator Device vs. methadone in alleviating opiate withdrawal symptoms.
Topics: Double-Blind Method; Electric Stimulation Therapy; Humans; Methadone; Opioid-Related Disorders; Pilo | 1989 |
Acute physical dependence in man: repeated naloxone-precipitated withdrawal after a single dose of methadone.
Topics: Double-Blind Method; Drug Administration Schedule; Humans; Methadone; Naloxone; Opioid-Related Disor | 1989 |
Buprenorphine detoxification from opioid dependence: a pilot study.
Topics: Adult; Buprenorphine; Clinical Trials as Topic; Female; Heroin Dependence; Humans; Male; Methadone; | 1988 |
Effects of information on the opiate withdrawal syndrome.
Topics: Adult; Female; Humans; Male; Methadone; Narcotics; Patient Education as Topic; Substance Withdrawal | 1988 |
Psychiatric indications for clonidine: the neuropharmacologic and clinical basis.
Topics: Animals; Anxiety; Bipolar Disorder; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug T | 1986 |
Clonidine treatment of the opiate withdrawal syndrome. A review of clinical trials of a theory.
Topics: Adrenergic Fibers; Animals; Antidepressive Agents, Tricyclic; Brain; Clinical Trials as Topic; Cloni | 1986 |
[Methadone, clonidine and levomepromazine in the treatment of opiate abstinence syndrome: double-blind clinical trial in heroin-addicted patients admitted to a general hospital for organic pathology].
Topics: Clonidine; Double-Blind Method; Female; Heroin; Hospitalization; Hospitals, General; Humans; Male; M | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Two new rating scales for opiate withdrawal.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Psychologi | 1987 |
Contingent methadone delivery: effects on illicit-opiate use.
Topics: Adult; Contraceptives, Oral, Combined; Dose-Response Relationship, Drug; Drug Administration Schedul | 1986 |
Success and failure at outpatient opioid detoxification. Evaluating the process of clonidine- and methadone-assisted withdrawal.
Topics: Adult; Ambulatory Care; Clinical Trials as Topic; Clonidine; Female; Follow-Up Studies; Humans; Male | 1985 |
Comparison of clinician ratings to self reports of withdrawal during clonidine detoxification of opiate addicts.
Topics: Adult; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Male; Methadone; Op | 1985 |
Clonidine in outpatient detoxification from methadone maintenance.
Topics: Adult; Ambulatory Care; Clonidine; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Diso | 1985 |
Limit setting on drug abuse in methadone maintenance patients.
Topics: Female; Humans; Illicit Drugs; Male; Methadone; Opioid-Related Disorders; Patient Compliance; Patien | 1985 |
Narcotic withdrawal symptoms in heroin users treated with propranolol.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Clinical Trials as Topic; Female; Heroin; Hu | 1972 |
Studies on the relationship between 5-hydroxytryptamine turnover in brain and tolerance and physical dependence in mice.
Topics: Animals; Aspirin; Brain; Cyclazocine; Drug Tolerance; Fenclonine; Humans; Levorphanol; Male; Methado | 1971 |
Propranolol in withdrawal from opiates.
Topics: Adult; Chloral Hydrate; Drug Therapy, Combination; Heroin Dependence; Humans; Methadone; Narcotic An | 1974 |
Methadyl acetate vs methadone. A double-blind study in heroin users.
Topics: Acetates; Administration, Oral; Adult; Amino Alcohols; Analysis of Variance; Benzene Derivatives; Cl | 1972 |
Detoxification of rehabilitated methadone-maintained patients.
Topics: Administration, Oral; Adult; Alcoholism; Black People; Clinical Trials as Topic; Family Characterist | 1973 |
A comparison of haloperidol with methadone in blocking heroin-withdrawal symptoms. A pilot study.
Topics: Adolescent; Adult; Clinical Trials as Topic; Haloperidol; Heroin Dependence; Humans; Methadone; Pilo | 1973 |
Low-dosage use of methadone in extended detoxification: An experimental comparison.
Topics: Adult; Ambulatory Care; Clinical Trials as Topic; Drug Evaluation; Female; Heroin Dependence; Hospit | 1974 |
Proceedings: Efficacy and side effects of three widely different methadone doses.
Topics: Adolescent; Adult; California; Clinical Trials as Topic; Community Health Services; Dose-Response Re | 1973 |
Physical versus psychological dependency during detoxification and maintenance.
Topics: Clinical Trials as Topic; Counseling; Georgia; Heroin Dependence; Humans; Male; Methadone; Methods; | 1973 |
Methadone--a reevaluation.
Topics: Administration, Oral; Affect; Blood Pressure; Body Temperature; Dose-Response Relationship, Drug; Dr | 1973 |
Comparison of acetylmethadol and methadone in the treatment of long-term heroin users. A pilot study.
Topics: Alcohols; Clinical Trials as Topic; Heroin; Humans; Methadone; Morphine Dependence; Placebos; Substa | 1970 |
Levomethadyl in maintenance treatment of opiate dependence.
Topics: Adult; Alcohols; Amphetamine; Barbiturates; Benzene Derivatives; Heroin; Humans; Injections, Intrave | 1972 |
785 other studies available for methadone and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Morphine dependence and withdrawal-induced changes in mouse Sertoli cell (TM4) line: Evaluation of apoptotic, inflammatory and oxidative stress biomarkers.
Topics: Analgesics, Opioid; Animals; Apoptosis; Biomarkers; Cell Line; Cyclic AMP; Glial Cell Line-Derived N | 2021 |
Opioid Weaning Protocol Using Morphine Compared With Nonprotocolized Methadone Associated With Decreased Dose and Duration of Opioid After Norwood Procedure.
Topics: Analgesics, Opioid; Child; Humans; Infant, Newborn; Methadone; Morphine; Norwood Procedures; Substan | 2022 |
Pharmacological Management of Heroin Withdrawal Syndrome: A Century of Expert Opinions in Cecil Textbook of Medicine.
Topics: Analgesics, Opioid; Buprenorphine; Clonidine; Expert Testimony; Heroin; Humans; Methadone; Narcotics | 2022 |
Bridge clinic implementation of "72-hour rule" methadone for opioid withdrawal management: Impact on opioid treatment program linkage and retention in care.
Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Opiate Substitution Treatment; Opioid-Related D | 2022 |
Effect of TRV130 and methadone on fentanyl-vs.-food choice and somatic withdrawal signs in opioid-dependent and post-opioid-dependent rats.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Fentanyl; Male; Methadone; Narcotics; Opioid-Related Dis | 2022 |
Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns.
Topics: Adult; Analgesics, Opioid; Codeine; Cohort Studies; Female; Humans; Hydrocodone; Hydromorphone; Infa | 2022 |
Implementation of an Opioid Weaning Protocol at a Tertiary Care Children's Hospital.
Topics: Analgesics, Opioid; Child; Female; Hospitals; Humans; Infant; Male; Methadone; Retrospective Studies | 2022 |
Managing acute opioid withdrawal with tramadol during COVID-19 lockdown in a peri-urban setting.
Topics: Adult; Analgesics, Opioid; Communicable Disease Control; COVID-19; Cross-Sectional Studies; Female; | 2022 |
Phenobarbital for alcohol withdrawal in the context of the opioid epidemic: a neglected caveat.
Topics: Alcoholism; Analgesics, Opioid; Buprenorphine; Humans; Methadone; Opiate Substitution Treatment; Opi | 2023 |
Methadone alters transcriptional programs associated with synapse formation in human cortical organoids.
Topics: Analgesics, Opioid; Brain; Female; Humans; Infant; Methadone; Opiate Substitution Treatment; Opioid- | 2023 |
Things We Do for No Reason™: Avoiding methadone for opioid withdrawal.
Topics: Analgesics, Opioid; Humans; Methadone; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syn | 2023 |
Sedation Weaning Initiative Targeting Methadone Exposure: Single Center Improvements in Withdrawal Symptoms and Hospital Length of Stay for Pediatric Cardiac Critical Care.
Topics: Child; Critical Care; Hospitals; Humans; Infant; Length of Stay; Methadone; Substance Withdrawal Syn | 2023 |
Methadone use for acute opioid withdrawal in Tshwane shelters during the COVID-19 lockdown.
Topics: Analgesics, Opioid; Communicable Disease Control; COVID-19; Cross-Sectional Studies; Humans; Methado | 2023 |
The imperative of clinical and molecular research on neonatal opioid withdrawal syndrome.
Topics: Analgesics, Opioid; Humans; Infant; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opioid | 2019 |
Iatrogenic Opiate Withdrawal in Pediatric Patients: Implementation of a Standardized Methadone Weaning Protocol and Withdrawal Assessment Tool.
Topics: Analgesics, Opioid; Child; Humans; Iatrogenic Disease; Methadone; Opiate Alkaloids; Substance Withdr | 2021 |
Association between mortality rates and medication and residential treatment after in-patient medically managed opioid withdrawal: a cohort analysis.
Topics: Adolescent; Adult; Buprenorphine; Cohort Studies; Drug Overdose; Female; Humans; Male; Massachusetts | 2020 |
Enriched Environment Ameliorates Cognitive Deficits and Locomotor Sensitization in Morphine-Withdrawn Rats Receiving Methadone Maintenance Treatment.
Topics: Animals; Cognitive Dysfunction; Locomotion; Male; Methadone; Morphine; Narcotics; Opiate Substitutio | 2020 |
Methadone-Assisted Opiate Withdrawal and Subsequent Heroin Abstinence: The Importance of Psychological Preparedness.
Topics: Adult; Analgesics, Opioid; Deprescriptions; Heroin; Heroin Dependence; Humans; Inpatients; Male; Met | 2021 |
Model-Based Approach to Improve Clinical Outcomes in Neonates With Opioid Withdrawal Syndrome Using Real-World Data.
Topics: Analgesics, Opioid; Electronic Health Records; Female; Hospitalization; Humans; Infant, Newborn; Len | 2021 |
Impulsivity and craving in subjects with opioid use disorder on methadone maintenance treatment.
Topics: Adult; Cognition; Craving; Executive Function; Female; Humans; Impulsive Behavior; Male; Methadone; | 2021 |
Methadone dose at delivery is not an accurate proxy for fetal exposure.
Topics: Buprenorphine; Humans; Infant, Newborn; Methadone; Opioid-Related Disorders; Substance Withdrawal Sy | 2021 |
Managing opioid withdrawal precipitated by buprenorphine with buprenorphine.
Topics: Analgesics, Opioid; Buprenorphine; Humans; Methadone; Narcotic Antagonists; Opioid-Related Disorders | 2021 |
European Court of Human Rights.
Topics: Adult; Buprenorphine; Europe; Female; Hospitals, State; Human Rights; Humans; Male; Methadone; Middl | 2020 |
Tobacco withdrawal among opioid-dependent smokers.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cigarette Smoking; Comorbidity; Craving; Female; Humans; M | 2018 |
Disulfiram attenuates morphine or methadone withdrawal syndrome in mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disulfiram; Male; Methadone; Mice; Mice, Inbred C57BL | 2018 |
Low dose intramuscular methadone for acute mild to moderate opioid withdrawal syndrome.
Topics: Adult; Analgesics, Opioid; Female; Humans; Injections, Intramuscular; Male; Methadone; Middle Aged; | 2018 |
Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment.
Topics: Animals; Anxiety; Depression; Exercise Test; Male; Maze Learning; Methadone; Morphine; Morphine Depe | 2018 |
The Association between the Level of Plasma Oxytocin and Craving among Former Heroin Users.
Topics: Adult; Behavior, Addictive; Craving; Female; Heroin Dependence; Humans; Male; Methadone; Opiate Subs | 2018 |
Management of opioid withdrawal symptoms.
Topics: Adrenergic alpha-2 Receptor Agonists; Buprenorphine; Clonidine; Humans; Methadone; Narcotic Antagoni | 2018 |
Expanded table: Some drugs for management of opioid withdrawal symptoms.
Topics: Adrenergic alpha-2 Receptor Agonists; Buprenorphine; Clonidine; Humans; Methadone; Narcotic Antagoni | 2018 |
Implementation of a Risk-Stratified Opioid and Benzodiazepine Weaning Protocol in a Pediatric Cardiac ICU.
Topics: Analgesics, Opioid; Benzodiazepines; Cardiovascular Diseases; Female; Humans; Hydromorphone; Infant; | 2018 |
Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence.
Topics: Adult; Buprenorphine; Factor Analysis, Statistical; Female; Humans; Infant, Newborn; Medication Adhe | 2018 |
Methadone to buprenorphine/naloxone induction without withdrawal utilizing transdermal fentanyl bridge in an inpatient setting-Azar method.
Topics: Administration, Cutaneous; Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Delayed-Act | 2018 |
Opioid Use Disorder and Incarceration - Hope for Ensuring the Continuity of Treatment.
Topics: Adult; Buprenorphine; Humans; Legislation, Medical; Male; Methadone; Narcotic Antagonists; Opiate Su | 2019 |
Rapid transition from methadone to buprenorphine using naltrexone-induced withdrawal: A case report.
Topics: Adult; Antidiarrheals; Antiemetics; Antipruritics; Buprenorphine; Clonidine; Deprescriptions; Drug S | 2019 |
Non-prescribed use of methadone and buprenorphine prior to opioid substitution treatment: lifetime prevalence, motives, and drug sources among people with opioid dependence in five Swedish cities.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cities; Drug Tra | 2019 |
Transitioning Hospitalized Patients with Opioid Use Disorder from Methadone to Buprenorphine without a Period of Opioid Abstinence Using a Microdosing Protocol.
Topics: Adult; Buprenorphine; Dose-Response Relationship, Drug; Drug Substitution; Female; Humans; Male; Met | 2019 |
Evaluation of a pharmacist-managed methadone taper*.
Topics: Adolescent; Analgesics, Opioid; Case-Control Studies; Child; Child, Preschool; Female; Hospitals, Pe | 2014 |
[No opiates against cannabis hyperemesis syndrome].
Topics: Adult; Antiemetics; Dronabinol; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combina | 2014 |
Methadone overdose and withdrawal in a tetraplegic patient: a case report.
Topics: Adult; Analgesics, Opioid; Drug Overdose; Female; Humans; Methadone; Pain; Quadriplegia; Spinal Cord | 2014 |
Methadone: who tapers, when, where, and how?*.
Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Opioid-Related Disorders; Pharmacists; Substanc | 2014 |
Exploring the Concepts of Abstinence and Recovery Through the Experiences of Long-Term Opiate Substitution Clients.
Topics: Analgesics, Opioid; Buprenorphine; Fear; Female; Humans; Male; Methadone; Middle Aged; Motivation; O | 2015 |
My trauma patient takes methadone: how do I manage his pain?
Topics: Accidents, Traffic; Analgesics, Opioid; Emergency Service, Hospital; Humans; Male; Methadone; Pain; | 2014 |
Failure to identify or effectively manage prescription opioid dependence acted as a gateway to heroin use-buprenorphine/naloxone treatment and recovery in a surgical patient.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Codeine; Disease Management; Female; Heroin; Heroin Depend | 2014 |
Adolescents at risk: pain pills to heroin: part II.
Topics: Adolescent; Analgesics, Opioid; Drug Overdose; Drug Substitution; Heroin; Heroin Dependence; Humans; | 2015 |
The relevance of the psychological evaluation in drug dependence.
Topics: Adult; Counseling; Humans; Methadone; Opioid-Related Disorders; Psychotherapy; Substance Withdrawal | 2014 |
Severe opioid withdrawal syndrome after a single dose of nalmefene.
Topics: Adult; Alcoholism; Analgesics, Opioid; Codeine; Contraindications; Drug Interactions; Humans; Male; | 2015 |
Simeprevir-induced severe withdrawal syndrome in an HIV/HCV coinfected patient on long-term maintenance methadone therapy.
Topics: Antiretroviral Therapy, Highly Active; Antiviral Agents; Coinfection; Drug Interactions; Hepatitis C | 2015 |
[Nalmefene and Opioid Withdrawal Syndrome: Analysis of the Global Pharmacovigilance Database for Adverse Drug Reactions].
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Alcoholism; Humans; Male; Methadone; Middle Ag | 2015 |
"I Kicked the Hard Way. I Got Incarcerated." Withdrawal from Methadone During Incarceration and Subsequent Aversion to Medication Assisted Treatments.
Topics: Adult; Female; Grounded Theory; Humans; Male; Methadone; Middle Aged; New York City; Opiate Substitu | 2016 |
US pledges better protection for babies born to addicts.
Topics: Adult; Child of Impaired Parents; Child Protective Services; Female; Heroin Dependence; Humans; Infa | 2016 |
The effect of chronic morphine or methadone exposure and withdrawal on clock gene expression in the rat suprachiasmatic nucleus and AA-NAT activity in the pineal gland.
Topics: Animals; Arginine Vasopressin; Circadian Rhythm; In Situ Hybridization; Male; Methadone; Morphine; N | 2016 |
Patients' Beliefs About Medications are Associated with Stated Preference for Methadone, Buprenorphine, Naltrexone, or no Medication-Assisted Therapy Following Inpatient Opioid Detoxification.
Topics: Adult; Buprenorphine; Delayed-Action Preparations; Female; Humans; Interviews as Topic; Male; Methad | 2016 |
Neonatal abstinence syndrome and the gastrointestinal tract.
Topics: Analgesics, Opioid; Buprenorphine; Child; Child, Preschool; Dysbiosis; Female; Gastrointestinal Trac | 2016 |
Sex and opioid maintenance dose influence response to naloxone in opioid-dependent humans: a retrospective analysis.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Methadyl Acetate; Naloxone | 2008 |
[Quality of life for drug abusers accepting methadone maintenance treatment].
Topics: Female; Humans; Male; Methadone; Opioid-Related Disorders; Quality of Life; Substance Withdrawal Syn | 2008 |
"Maintenance" treatment of addiction: to whose credit, and why it matters.
Topics: Analgesics, Opioid; Health Policy; Health Services Accessibility; Heroin Dependence; History, 20th C | 2009 |
Dysfunction of the hypothalamic-pituitary-adrenal axis in opioid dependent subjects: effects of acute and protracted abstinence.
Topics: Adrenocorticotropic Hormone; Adult; Benzodiazepines; Clonidine; Corticotropin-Releasing Hormone; Fem | 2008 |
Slow-release oral morphine for maintenance treatment of opioid addicts intolerant to methadone or with inadequate withdrawal suppression.
Topics: Adult; Delayed-Action Preparations; Female; Humans; Male; Methadone; Middle Aged; Morphine; Narcotic | 2008 |
Real-time electronic diary reports of cue exposure and mood in the hours before cocaine and heroin craving and use.
Topics: Adult; Affect; Ambulatory Care; Cocaine-Related Disorders; Combined Modality Therapy; Computers, Han | 2009 |
Major depressive disorder and patient satisfaction in relation to methadone pharmacokinetics and pharmacodynamics in stabilized methadone maintenance patients.
Topics: Adult; Depressive Disorder, Major; Diagnosis, Dual (Psychiatry); Female; Humans; Male; Methadone; Na | 2009 |
[Treatment of opioid withdrawal].
Topics: Buprenorphine; Humans; Methadone; Narcotics; Opioid-Related Disorders; Social Support; Substance Wit | 2009 |
Feasability and safety of transfer from racemic methadone to (R)-methadone in primary care: clinical results from an open study.
Topics: Adult; Feasibility Studies; Female; Follow-Up Studies; Humans; Male; Methadone; Narcotics; Opioid-Re | 2009 |
Buprenorphine withdrawal in a toddler.
Topics: Analgesics, Opioid; Buprenorphine; Child, Preschool; Critical Care; Emergency Medicine; Female; Huma | 2009 |
Incarceration and opioid withdrawal: the experiences of methadone patients and out-of-treatment heroin users.
Topics: Adult; Female; Heroin Dependence; Humans; Male; Methadone; Opioid-Related Disorders; Prisoners; Subs | 2009 |
Exploring the relationship between perceived inter-dose opioid withdrawal and patient characteristics in methadone maintenance treatment.
Topics: Adult; Affect; Anxiety; Behavior, Addictive; Female; Humans; Male; Methadone; Opioid-Related Disorde | 2009 |
[Change and influence factors of craving for patients after 6 month methadone maintenance treatment].
Topics: Adult; China; Female; Heroin Dependence; Humans; Male; Methadone; Substance Withdrawal Syndrome; Sur | 2009 |
Postnatal methadone withdrawal syndrome: hair analysis for detecting chronic exposure.
Topics: Gas Chromatography-Mass Spectrometry; Hair; Heroin Dependence; Humans; Immunoassay; Infant; Lethargy | 2010 |
[A case report on methadone withdrawal syndrome].
Topics: Adult; Heroin Dependence; Humans; Male; Methadone; Substance Withdrawal Syndrome | 2009 |
[Guideline 'Medicinal care for drug addicts in penal institutions'].
Topics: Analgesics, Opioid; Buprenorphine; Dose-Response Relationship, Drug; Humans; Methadone; Naloxone; Ne | 2009 |
Methadone maintenance treatment: the need to distinguish between holding dose, dose adequacy, satisfaction with methadone as a medication, and satisfaction with treatment.
Topics: Depressive Disorder, Major; Diagnosis, Dual (Psychiatry); Drug Administration Schedule; Humans; Meth | 2010 |
First case of stress cardiomyopathy as a result of methadone withdrawal secondary to drug-drug interaction.
Topics: Adult; Drug Interactions; Echocardiography; Electrocardiography; Humans; Male; Methadone; Naltrexone | 2010 |
Intravenous misuse of buprenorphine: characteristics and extent among patients undergoing drug maintenance therapy.
Topics: Administration, Sublingual; Adolescent; Adult; Age Factors; Analgesics, Opioid; Behavior, Addictive; | 2010 |
Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome.
Topics: Breast Feeding; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Infant, Premature | 2011 |
Daily life hour by hour, with and without cocaine: an ecological momentary assessment study.
Topics: Adult; Affect; Cocaine; Cocaine-Related Disorders; Cohort Studies; Computers, Handheld; Female; Hero | 2010 |
Medical treatment of opioid dependence within the South African context.
Topics: Buprenorphine; Drug Combinations; Drug Overdose; Humans; Methadone; Motivation; Naloxone; Narcotic A | 2010 |
The first 38 methadone maintenance treatment patients in Stockholm: 15-year follow-up with a main focus on detoxification from methadone.
Topics: Adult; Female; Follow-Up Studies; Humans; Illicit Drugs; Male; Methadone; Middle Aged; Narcotics; Op | 2011 |
Factors associated with complicated buprenorphine inductions.
Topics: Adult; Benzodiazepines; Buprenorphine; Community Health Centers; Dose-Response Relationship, Drug; F | 2010 |
Self-reported side effects in buprenorphine and methadone patients receiving antiretroviral therapy: results from the MANIF 2000 cohort study.
Topics: Anti-Retroviral Agents; Attitude to Health; Buprenorphine; Cohort Studies; Depression; Female; Franc | 2010 |
"Should I stay or should I go?" Coming off methadone and buprenorphine treatment.
Topics: Analgesics, Opioid; Buprenorphine; Consumer Health Information; Cross-Sectional Studies; Female; Hum | 2011 |
Heroin-dependent inmates' experiences with buprenorphine or methadone maintenance.
Topics: Adult; Buprenorphine; Heroin Dependence; Humans; Male; Methadone; Narcotics; New York City; Opiate S | 2010 |
MR spectroscopy in opiate maintenance therapy: association of glutamate with the number of previous withdrawals in the anterior cingulate cortex.
Topics: Adult; Analysis of Variance; Buprenorphine; Case-Control Studies; Female; Glutamic Acid; Gyrus Cingu | 2012 |
The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of substance use and related disorders. Part 2: Opioid dependence.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Buprenorphine; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2D | 2011 |
Usefulness of methadone plasma concentration measurement in patients receiving nevirapine or efavirenz.
Topics: Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Dose-Response Relations | 2011 |
Creating or preventing opioid addiction, finding the right dose.
Topics: Female; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Care Units, Pediatric; Male; Methadone; | 2011 |
Genetic polymorphisms in CYP3A4 are associated with withdrawal symptoms and adverse reactions in methadone maintenance patients.
Topics: Adult; Amitriptyline; Areca; Biomarkers, Pharmacological; Cytochrome P-450 CYP3A; Female; Genetic As | 2011 |
Sexual function of 612 male addicts treated by methadone.
Topics: Adult; Erectile Dysfunction; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Substance With | 2011 |
Outcome of heroin-dependent adolescents presenting for opiate substitution treatment.
Topics: Adolescent; Buprenorphine; Cohort Studies; Female; Heroin Dependence; Humans; Male; Methadone; Narco | 2012 |
Withdrawal treatment with clonidine after prolonged use of chloral hydrate in a pediatric intensive care patient.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Chloral Hydrate; Clonidine; Fentanyl; Humans; Hypnoti | 2011 |
Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Dose-Response Relationship, Drug; Drug Tolerance; End | 2012 |
[Abstinence from cocaine after long-term addiction].
Topics: Adaptation, Psychological; Adult; Behavior, Addictive; Cocaine-Related Disorders; Comorbidity; Crack | 2011 |
Strength in numbers: a step closer to standardising perinatal care for drug-misusing women and their infants.
Topics: Female; Humans; Methadone; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregna | 2012 |
Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Arrhythmias, Cardiac; Drug Interactions; Female; | 2012 |
Treatment of opioid dependence in the setting of pregnancy.
Topics: Adolescent; Alcohol-Related Disorders; Analgesics, Opioid; Buprenorphine; Child; Comorbidity; Delive | 2012 |
UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients.
Topics: Adult; Amitriptyline; Female; Genetic Association Studies; Glucuronosyltransferase; Haplotypes; Hero | 2012 |
Effect of lersivirine co-administration on pharmacokinetics of methadone in healthy volunteers.
Topics: Adolescent; Adult; Anti-HIV Agents; Area Under Curve; Chromatography, High Pressure Liquid; Drug Int | 2012 |
[Lactic acidosis due to thiamine deficiency].
Topics: Acidosis, Lactic; Anorexia; Asthenia; Buprenorphine; Cachexia; Humans; Male; Methadone; Middle Aged; | 2012 |
(1) H-nuclear magnetic resonance-based metabonomic analysis of brain in rhesus monkeys with morphine treatment and withdrawal intervention.
Topics: Animals; Brain; Disease Models, Animal; Female; Macaca mulatta; Magnetic Resonance Spectroscopy; Mal | 2012 |
Impact of enteral methadone on the ability to wean off continuously infused opioids in critically ill, mechanically ventilated adults: a case-control study.
Topics: Adult; Aged; Analgesics, Opioid; Case-Control Studies; Critical Illness; Enteral Nutrition; Female; | 2012 |
Association between cholesterol plasma levels and craving among heroin users.
Topics: Adult; Body Mass Index; Cholesterol; Female; Heroin; Heroin Dependence; Humans; Male; Methadone; Mid | 2012 |
Pharmacokinetic-pharmacodynamic modeling of mood and withdrawal symptoms in relation to plasma concentrations of methadone in patients undergoing methadone maintenance treatment.
Topics: Affect; Age Factors; Chromatography, Liquid; Cytochrome P-450 CYP3A; Female; Humans; Male; Mass Spec | 2012 |
Opioid overdose prevention with intranasal naloxone among people who take methadone.
Topics: Administration, Intranasal; Adult; Drug Overdose; Female; HIV Infections; Humans; Male; Massachusett | 2013 |
Opioid dependence.
Topics: Buprenorphine; Clonidine; Evidence-Based Medicine; Humans; Inactivation, Metabolic; Methadone; Nalox | 2012 |
Patterns of symptom reporting during pregnancy comparing opioid maintained and control women.
Topics: Adult; Buprenorphine; Case-Control Studies; Female; Humans; Methadone; Opiate Substitution Treatment | 2012 |
Predictive factors of persisting illicit drug use in hospitalized heroin addicts.
Topics: Adult; Chi-Square Distribution; Cocaine; Discriminant Analysis; Female; Heroin Dependence; Humans; I | 2002 |
Relationship between maternal methadone dosage and neonatal withdrawal.
Topics: Adult; Analysis of Variance; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration S | 2002 |
Discrimination of a single dose of morphine followed by naltrexone: substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependence.
Topics: Acute Disease; Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Male; Methadone; Morph | 2003 |
Major disruptions of sleep during treatment of the opiate withdrawal syndrome: differences between methadone and lofexidine detoxification treatments.
Topics: Clonidine; Humans; Methadone; Narcotic Antagonists; Narcotics; Sleep Wake Disorders; Substance Withd | 2003 |
Heroin and strabismus.
Topics: Adult; Diplopia; Esotropia; Female; Heroin; Humans; Male; Methadone; Narcotics; Retrospective Studie | 2003 |
[Opiates withdrawal syndrome after treatment with zidovudine + lamivudine + abcavir in patients with positivity for HIV and treated with methadone].
Topics: Adult; Anti-HIV Agents; Dideoxynucleosides; Drug Combinations; Humans; Lamivudine; Male; Methadone; | 2003 |
Is opiate detoxification unsafe in pregnancy?
Topics: Abortion, Spontaneous; Adult; Female; Heroin; Humans; Methadone; Obstetric Labor, Premature; Opioid- | 2003 |
The protease inhibitor lopinavir-ritonavir may produce opiate withdrawal in methadone-maintained patients.
Topics: HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Methadone; Narcotics; Opioid-Related Dis | 2003 |
Management of the narcotic withdrawal syndrome in the neonate.
Topics: Barbiturates; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exc | 1963 |
SURGERY ON THE NARCOTIC ADDICT.
Topics: Abscess; Asthma; Barbiturates; Cicatrix; Diagnosis; Hepatitis; Humans; Injections; Injections, Intra | 1964 |
A CLINICAL TRIAL OF A MIXTURE OF LEVORPHANOL AND LEVALLORPHAN AS AN ORAL ANALEGESIC.
Topics: Drug Therapy; Humans; Levallorphan; Levorphanol; Methadone; Neoplasms; Osteoarthritis; Pain; Substan | 1964 |
A MEDICAL TREATMENT FOR DIACETYLMORPHINE (HEROIN) ADDICTION. A CLINICAL TRIAL WITH METHADONE HYDROCHLORIDE.
Topics: Adolescent; Drug Therapy; Drug Tolerance; Heroin; Humans; Methadone; Substance Withdrawal Syndrome; | 1965 |
NARCOTIC DRUG ADDICTION: ONE YEAR'S EXPERIECES AT PILGRIM STATE HOSPITAL.
Topics: Drug Therapy; Hepatitis; Homosexuality; Hospitals, Psychiatric; Hospitals, State; Humans; Legislatio | 1965 |
Long-term methadone maintenance effectiveness: psychosocial and pharmacological variables.
Topics: Adult; Comorbidity; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heroin D | 2003 |
[Interaction between methadone and antiretrovirals (stavudine, indinavir, ritonavir, nevirapine)].
Topics: Anti-HIV Agents; Drug Interactions; Female; Humans; Indinavir; Male; Methadone; Narcotics; Nevirapin | 2003 |
Methadone dosage for prevention of opioid withdrawal in children.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; F | 2003 |
Severe intraoperative hypertension and opioid-resistant postoperative pain in a methadone-treated patient.
Topics: Adult; Analgesics, Opioid; Drug Resistance; Female; Hemodynamics; Humans; Hypertension; Intraoperati | 2003 |
[Relations between the care recipients and nurses. Auto-efficiency or urgency of resources].
Topics: Adaptation, Psychological; Adult; Efficiency; Female; Heroin Dependence; Humans; Methadone; Motivati | 2003 |
[Detoxification in withdrawal state in methadone maintenance patients].
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Data Interpretation, Statistical; Heroin Dependence; Hu | 2003 |
Outcomes of infants born to mothers receiving methadone for pain management in pregnancy.
Topics: Analgesics, Opioid; Chronic Disease; Delivery, Obstetric; Drug Administration Schedule; Female; Gest | 2004 |
The emperor' s new clothes.
Topics: Analgesics, Opioid; Buprenorphine; Clinical Trials as Topic; Clonidine; Heroin Dependence; Humans; M | 2003 |
Withdrawal symptoms during chronic transdermal fentanyl administration managed with oral methadone.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Analgesics, Opioid; Female; Fentanyl; Humans | 2004 |
Unexpected delirium during Rapid Opioid Detoxification (ROD).
Topics: Adult; Alcohol Withdrawal Delirium; Clonidine; Diagnostic and Statistical Manual of Mental Disorders | 2004 |
Pleasure into pain: the consequences of long-term opioid use.
Topics: Analgesics, Opioid; Drug Tolerance; Humans; Hyperalgesia; Methadone; Mood Disorders; Narcotics; Sens | 2004 |
Cerebral phosphorus metabolite and transverse relaxation time abnormalities in heroin-dependent subjects at onset of methadone maintenance treatment.
Topics: Adenosine Triphosphate; Adult; Basal Ganglia; Cerebral Cortex; Cross-Sectional Studies; Energy Metab | 2004 |
Jail management of arrestees/inmates enrolled in community methadone maintenance programs.
Topics: Heroin Dependence; Humans; Methadone; Prisoners; Substance Withdrawal Syndrome; United States | 2004 |
Subjective and physiological responses among racemic-methadone maintenance patients in relation to relative (S)- vs. (R)-methadone exposure.
Topics: Adult; Area Under Curve; Blood Pressure; Female; Heart Rate; Humans; Isomerism; Male; Methadone; Mid | 2004 |
Treating opiate addiction, Part I. Detoxification and maintenance.
Topics: Buprenorphine; Drug Combinations; Humans; Methadone; Naloxone; Narcotics; Opioid-Related Disorders; | 2004 |
Management of opiate detoxification in jails.
Topics: Acute Disease; Adrenergic alpha-Agonists; Clonidine; Health Care Surveys; Humans; Methadone; Narcoti | 2005 |
[Methadone and sleep apnea syndrome].
Topics: Adult; Brain; Clonidine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Drug Administr | 2005 |
The clinical management of substance misusers in police custody -- a survey of current practice.
Topics: Analgesics, Opioid; Attitude of Health Personnel; Codeine; Female; Forensic Medicine; Humans; Male; | 2005 |
Reversal of morphine, methadone and heroin induced effects in mice by naloxone methiodide.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Drug Interactions; Female; Heroin; Male; Methad | 2006 |
A comparison of voucher-delivery schedules for the initiation of cocaine abstinence.
Topics: Adult; Cocaine-Related Disorders; Female; Humans; Male; Methadone; Middle Aged; Motivation; Patient | 2005 |
Within- and between- subject variability in methadone pharmacokinetics and pharmacodynamics in methadone maintenance subjects.
Topics: Adult; Area Under Curve; Female; Heart Rate; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid | 2005 |
Low efficacy of non-opioid drugs in opioid withdrawal symptoms.
Topics: Adult; Buprenorphine; Drug Administration Schedule; Female; Humans; Inactivation, Metabolic; Male; M | 2005 |
Free and bound enantiomers of methadone and its metabolite, EDDP in methadone maintenance treatment: relationship to dosage?
Topics: Blood Proteins; Dose-Response Relationship, Drug; Humans; Methadone; Molecular Weight; Protein Bindi | 2005 |
Bradycardia during methadone therapy in an infant.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Bradycardia; Fentanyl; Humans; Infant; Male; Methadone | 2006 |
Choice between heroin and food in nondependent and heroin-dependent rhesus monkeys: effects of naloxone, buprenorphine, and methadone.
Topics: Animals; Buprenorphine; Disease Models, Animal; Feeding Behavior; Heroin; Heroin Dependence; Macaca | 2006 |
Slow tapering from methadone maintenance in a program encouraging indefinite maintenance.
Topics: Adult; Buprenorphine; Drug Administration Schedule; Female; Heroin Dependence; Humans; Male; Mental | 2006 |
Association between the DRD2 A1 allele and response to methadone and buprenorphine maintenance treatments.
Topics: Adult; Alleles; Analgesics, Opioid; Buprenorphine; Deoxyribonucleases, Type II Site-Specific; Female | 2006 |
Elimination of methadone benefits in the Oregon Health Plan and its effects on patients.
Topics: Eligibility Determination; Female; Financing, Personal; Follow-Up Studies; Health Policy; Humans; In | 2006 |
[Anesthesia and analgesia in addicts: basis for establishing a standard operating procedure].
Topics: Analgesics; Analgesics, Opioid; Anesthesia; Diagnosis, Dual (Psychiatry); Drug Tolerance; Humans; Hy | 2006 |
Fluctuations in (R,S)-methadone pharmacokinetics and response among long-term methadone maintenance patients.
Topics: Adolescent; Adult; Aged; Chromatography, High Pressure Liquid; Female; Heroin Dependence; Humans; Ma | 2006 |
Methadone doses upon multiple readmissions to inpatient detoxification: Clinical evidence for very moderate opioid tolerance.
Topics: Drug Tolerance; Female; Humans; Male; Methadone; Patient Readmission; Substance Withdrawal Syndrome | 2006 |
A chart review comparing paregoric to methadone in the treatment of neonatal opioid withdrawal.
Topics: Analgesics, Opioid; Documentation; Drug Administration Schedule; Female; Humans; Infant, Newborn; Ma | 2006 |
Depression in methadone maintenance treatment patients: rate and risk factors.
Topics: Adult; Benzodiazepines; Brief Psychiatric Rating Scale; Cocaine; Cocaine-Related Disorders; Comorbid | 2007 |
Naltrexone-assisted rapid methadone discontinuation: a pilot study.
Topics: Adult; Drug Evaluation, Preclinical; Female; Heroin Dependence; Humans; Male; Methadone; Naltrexone; | 2007 |
Electrophysiological evidence of the motivational salience of drug cues in opiate addiction.
Topics: Adult; Arousal; Attention; Cues; Electroencephalography; Event-Related Potentials, P300; Female; Her | 2007 |
Opiate exposure in breastfeeding newborns.
Topics: Analgesics, Opioid; Breast Feeding; Female; Humans; Infant, Newborn; Male; Methadone; Substance With | 2007 |
Client and counselor attitudes toward the use of medications for treatment of opioid dependence.
Topics: Adult; Ambulatory Care; Attitude of Health Personnel; Buprenorphine; Clonidine; Counseling; Culture; | 2007 |
Psychometric evaluation of the Dutch version of the Subjective Opiate Withdrawal Scale (SOWS).
Topics: Adult; Anxiety; Body Temperature; Body Temperature Regulation; Facial Expression; Heroin Dependence; | 2007 |
[Guidelines for acute detoxication and substitution treatment in persons unknown or only superficially known to the physician].
Topics: Buprenorphine; Drug Prescriptions; Humans; Inactivation, Metabolic; Methadone; Naloxone; Narcotic An | 2007 |
Chronic methadone treatment and repeated withdrawal impair cognition and increase the expression of apoptosis-related proteins in mouse brain.
Topics: Animals; Apoptosis Regulatory Proteins; Brain; Dose-Response Relationship, Drug; Male; Maze Learning | 2007 |
Risk factors for methadone outside treatment programs: implications for HIV treatment among injection drug users.
Topics: Adolescent; Adult; Analgesics, Opioid; Female; HIV Infections; Humans; Illicit Drugs; Male; Methadon | 2007 |
Does naltrexone affect craving in abstinent opioid-dependent patients?
Topics: Adult; Female; Heroin; Heroin Dependence; Humans; Longitudinal Studies; Male; Methadone; Middle Aged | 2007 |
Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers.
Topics: Adult; Blood Pressure; China; Cues; Heart Rate; Heroin Dependence; Humans; Male; Methadone; Mood Dis | 2007 |
Buprenorphine and methadone: a comparison of patient completion rates during inpatient detoxification.
Topics: Adolescent; Adult; Buprenorphine; Female; Follow-Up Studies; Hospitals, Teaching; Humans; Length of | 2007 |
Diphenoxylate hydrochloride dependency.
Topics: Adult; Antidiarrheals; Clonidine; Diphenoxylate; Dose-Response Relationship, Drug; Drug Therapy, Com | 2007 |
Prescription opioid use, misuse, and diversion among street drug users in New York City.
Topics: Administration, Intranasal; Adult; Aged; Analgesics, Opioid; Buprenorphine; Cocaine-Related Disorder | 2008 |
Influence of the dose on the severity of opiate withdrawal symptoms during methadone detoxification.
Topics: Adult; Female; Humans; Length of Stay; Male; Methadone; Opioid-Related Disorders; Severity of Illnes | 2008 |
Exploring the prevalence of menopause symptoms in midlife women in methadone maintenance treatment.
Topics: Adult; Chi-Square Distribution; Cross-Sectional Studies; Depression; Female; Health Surveys; HIV Inf | 2007 |
Use of methadone to combat withdrawal symptoms of dilaudid addiction; case report.
Topics: Behavior, Addictive; Drug-Related Side Effects and Adverse Reactions; Humans; Hydromorphone; Methado | 1949 |
Ethical and human rights imperatives to ensure medication-assisted treatment for opioid dependence in prisons and pre-trial detention.
Topics: Buprenorphine; Health Services Accessibility; Human Rights; Humans; Methadone; Narcotics; Opioid-Rel | 2008 |
Facilitation of avoidance behaviour in mice chronically treated with heroin or methadone.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Drug Administration Schedule; F | 2008 |
Chronic exposure of human macrophages in vitro to morphine and methadone induces a putative tolerant/dependent state.
Topics: Adolescent; Adult; Analysis of Variance; Cell Differentiation; Cells, Cultured; Dose-Response Relati | 2008 |
Rehabilitation and the narcotic addict: results of a comparative methadone withdrawal program.
Topics: Adolescent; Adult; British Columbia; Community Mental Health Services; Humans; Methadone; Psychother | 1967 |
Narcotics and medical practice. Medical use of morphine and morphine-like drugs and management of persons dependent on them.
Topics: Amphetamine; Barbiturates; Cannabis; Drug and Narcotic Control; Female; Heroin; Humans; Legislation, | 1967 |
Guanabenz acetate: a new, long-acting alpha-two adrenergic agonist for opioid withdrawal.
Topics: Adult; Blood Pressure; Delayed-Action Preparations; Female; Guanabenz; Guanidines; Heroin Dependence | 1984 |
Clonidine hydrochloride detoxification from methadone treatment--the value of naltrexone aftercare.
Topics: Adult; Aftercare; Attitude to Health; Clonidine; Female; Follow-Up Studies; Humans; Male; Methadone; | 1984 |
Clonidine and opiate withdrawal.
Topics: Clonidine; Humans; Methadone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1980 |
Outpatient clonidine detoxification.
Topics: Clonidine; Humans; Methadone; Outpatients; Patients; Substance Withdrawal Syndrome; Substance-Relate | 1981 |
Acute phase of drug withdrawal management by clothiapine (Entumin): a pilot project.
Topics: Adolescent; Adult; Alcoholism; Dibenzothiazepines; Female; Humans; Lysergic Acid Diethylamide; Male; | 1980 |
Substitution-detoxification and its role in the management of chronic benign pain.
Topics: Acute Disease; Analgesics, Opioid; Chronic Disease; Drug Administration Schedule; Humans; Hypnotics | 1982 |
Clinical comparison of propoxyphene napsylate and methadone in the treatment of opiate dependence.
Topics: Adult; Dextropropoxyphene; Double-Blind Method; Heroin Dependence; Humans; Male; Methadone; Middle A | 1982 |
Treatment of drug and addiction in London.
Topics: Evaluation Studies as Topic; Humans; Legislation, Drug; London; Methadone; Narcotics; Philosophy, Me | 1983 |
Contingency management of supplemental drug use during methadone maintenance treatment.
Topics: Alcohol Drinking; Anti-Anxiety Agents; Behavior Therapy; Benzodiazepines; Humans; Methadone; Narcoti | 1984 |
Progress report from the NIDA Addiction Research Center, Baltimore, Maryland.
Topics: Anti-Anxiety Agents; Buprenorphine; Double-Blind Method; Dronabinol; Drug Synergism; Heroin Dependen | 1984 |
[The need for psychopharmacologic therapy of drug addicts with acute hepatitis].
Topics: Acute Disease; Diazepam; Drug Therapy, Combination; Hepatitis; Heroin Dependence; Humans; Methadone; | 1984 |
Zinc tannate salts of heroin, LAAM and hydromorphone attenuate opiate withdrawal syndrome.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Codeine; Delayed-Action Preparations; Hero | 1980 |
Children of methadone-maintained mothers: follow-up to 18 months of age.
Topics: Abnormalities, Drug-Induced; Developmental Disabilities; Female; Follow-Up Studies; Humans; Infant; | 1982 |
Effect of acute methadone withdrawal on prostaglandin E-stimulated 3H-cyclic adenosine monophosphate accumulation in human platelets.
Topics: Adenylyl Cyclases; Blood Platelets; Cell Line; Cyclic AMP; Humans; Methadone; Morphine Dependence; N | 1980 |
Buprenorphrine: demonstration of physical dependence liability.
Topics: Animals; Buprenorphine; Drug Tolerance; Humans; Male; Methadone; Morphinans; Morphine; Naloxone; Rat | 1981 |
Urinary catecholamines, plasma renin activity and blood pressure in newborns: effects of narcotic withdrawal.
Topics: Catecholamines; Diastole; Female; Heroin; Humans; Hypertension; Infant, Newborn; Infant, Newborn, Di | 1981 |
Evidence for an endorphin dysfunction in methadone addicts: lack of ACTH response to naloxone.
Topics: Adrenocorticotropic Hormone; Endorphins; Humans; Male; Methadone; Naloxone; Opioid-Related Disorders | 1981 |
Methadone-induced endorphin dysfunction in addicts.
Topics: Adrenocorticotropic Hormone; Brain; Endorphins; Humans; Hydrocortisone; Male; Methadone; Naloxone; N | 1982 |
Recent advances in opiate detoxification: clonidine and lofexidine.
Topics: Clonidine; Humans; Methadone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1983 |
Relationship of plasma level and pharmacological activity of methadone.
Topics: Animals; Biotransformation; Brain; Dose-Response Relationship, Drug; Humans; Metabolic Clearance Rat | 1984 |
Self-administration of clonidine and oxazepam by methadone detoxification patients.
Topics: Adult; Clonidine; Humans; Male; Methadone; Opioid-Related Disorders; Oxazepam; Psychomotor Performan | 1984 |
Perinatal addiction: the effects of maternal narcotic and nonnarcotic substance abuse on the fetus and neonate.
Topics: Adult; Arousal; Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, D | 1984 |
Methadone detoxification: effects of methadone dose versus time in treatment.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Humans; | 1984 |
Phenomenology and theoretical basis of tolerance and dependence.
Topics: Adaptation, Psychological; Behavior; Chemoreceptor Cells; Drug Tolerance; Hemodynamics; Humans; Male | 1984 |
Various factors which affect the rate of development of tolerance and physical dependence to abused drugs.
Topics: Animals; Body Weight; Drug Tolerance; Humans; Methadone; Methadyl Acetate; Morphine; Naloxone; Rats; | 1984 |
Strategies to improve compliance with narcotic antagonists.
Topics: Combined Modality Therapy; Humans; Life Style; Methadone; Naloxone; Naltrexone; Opioid-Related Disor | 1984 |
Street pharmacology: uses of cocaine and heroin in the treatment of addiction.
Topics: Adult; Cocaine; Drug Interactions; Female; Heroin; Heroin Dependence; Humans; Illicit Drugs; Male; M | 1984 |
The Moro reaction: a scoring system for neonatal narcotic withdrawal.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pregnancy; Reflex, Startle; S | 1984 |
Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome.
Topics: Adult; Biotransformation; Female; Heroin Dependence; Humans; Male; Methadone; Phenobarbital; Substan | 1984 |
Methadone and naltrexone in the treatment of heroin dependence.
Topics: Heroin Dependence; Humans; Methadone; Naloxone; Naltrexone; Psychotherapy; Substance Withdrawal Synd | 1984 |
Neonatal opiate withdrawal alters the reactivity of adult rats to the hot-plate.
Topics: Animals; Dose-Response Relationship, Drug; Escape Reaction; Female; Humans; Male; Methadone; Methady | 1984 |
DSIP in the treatment of withdrawal syndromes from alcohol and opiates.
Topics: Adult; Delta Sleep-Inducing Peptide; Ethanol; Female; Heroin; Humans; Injections, Intravenous; Male; | 1984 |
Opiate withdrawal with clonidine.
Topics: Clonidine; Humans; Methadone; Nursing Assessment; Opioid-Related Disorders; Substance Withdrawal Syn | 1983 |
Clonidine treatment of neonatal narcotic abstinence syndrome.
Topics: Administration, Oral; Clonidine; Dose-Response Relationship, Drug; Humans; Infant, Newborn; Methadon | 1984 |
The clinical effectiveness of electrostimulation vs oral methadone in managing opiate withdrawal.
Topics: Adult; Electric Stimulation Therapy; Female; Humans; Male; Methadone; Opioid-Related Disorders; Subs | 1984 |
Drug addiction during pregnancy.
Topics: Birth Weight; Delivery, Obstetric; Female; Fetal Monitoring; Follow-Up Studies; Heroin; Heroin Depen | 1983 |
Methadone maintenance treatment: the other side of the coin.
Topics: Drug Tolerance; Euphoria; Heroin Dependence; Humans; Methadone; Opioid-Related Disorders; Personalit | 1983 |
Short-course diphenoxylate hydrochloride for treatment of methadone withdrawal symptoms.
Topics: Adult; Diphenoxylate; Female; Humans; Isonipecotic Acids; Male; Methadone; Pilot Projects; Substance | 1983 |
Patient perspectives of opiate withdrawal.
Topics: Attitude of Health Personnel; Attitude to Health; Humans; Male; Methadone; Opioid-Related Disorders; | 1983 |
Coordination of services to methadone mothers and their addicted newborns.
Topics: Child Abuse; Child Welfare; Child, Preschool; Female; Hospital Departments; Humans; Infant; Infant, | 1983 |
Overall evaluation of treatment modalities for heroin addiction in a toxicology unit.
Topics: Clonidine; Heroin Dependence; Hospital Units; Humans; Methadone; Morphine; Naloxone; Narcotics; Outc | 1983 |
Withdrawal tolerance and unidirectional non-cross-tolerance in narcotic pellet-implanted mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Etorphine; Heroin; Humans; | 1983 |
Opiate withdrawal increases ornithine decarboxylase activity which is otherwise unaltered in brains of dependent chicken fetuses.
Topics: Animals; Brain; Carboxy-Lyases; Chick Embryo; Humans; Methadone; Methadyl Acetate; Naloxone; Ornithi | 1983 |
Methadone, monoamine oxidase, and depression: opioid distribution and acute effects on enzyme activity.
Topics: Animals; Depression; Humans; Hypothalamus; Limbic System; Liver; Male; Methadone; Monoamine Oxidase; | 1983 |
Plasma testosterone and luteinizing hormone levels during levo-alpha-acetylmethadol maintenance and withdrawal.
Topics: Adult; Humans; Luteinizing Hormone; Male; Methadone; Methadyl Acetate; Opioid-Related Disorders; Pit | 1984 |
Depression during methadone withdrawal: no role for beta-phenylethylamine.
Topics: 2-Hydroxyphenethylamine; Adult; Depression; Female; Humans; Liver Function Tests; Male; Methadone; M | 1984 |
Single-day methadone dose alteration: detectability and symptoms.
Topics: Adult; Dose-Response Relationship, Drug; Humans; Individuality; Male; Methadone; Substance Withdrawa | 1984 |
Ventilatory response to carbon dioxide of infants following chronic prenatal methadone exposure.
Topics: Carbon Dioxide; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone; Oxygen; Partial | 1980 |
Methadone maintenance: a theoretical perspective.
Topics: Adolescent; Animals; Heroin Dependence; Humans; Internal-External Control; Methadone; Models, Psycho | 1980 |
Clonidine hydrochloride detoxification from methadone treatments: the value of naltrexone aftercare.
Topics: Adolescent; Clonidine; Humans; Inactivation, Metabolic; Methadone; Naloxone; Naltrexone; Opium; Subs | 1981 |
Type of pre-treatment income and response to treatment in methadone maintenance.
Topics: Data Collection; Employment; Humans; Income; Male; Methadone; Patient Admission; Population; Social | 1981 |
Dopamine and serum prolactin in methadone withdrawal.
Topics: Clonidine; Dopamine; Humans; Methadone; Prolactin; Substance Withdrawal Syndrome; Time Factors | 1981 |
[Clonidine in opiate withdrawal. I. Principles of application (author's transl)].
Topics: Clonidine; Humans; Methadone; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1982 |
Altered respiratory control in newborn puppies after chronic prenatal exposure to alpha-1-acetylmethadol (LAAM).
Topics: Animals; Animals, Newborn; Carbon Dioxide; Chloral Hydrate; Dogs; Female; Humans; Methadone; Methady | 1982 |
Self-regulated opioid detoxification by humans: effects of methadone pretreatment.
Topics: Adult; Humans; Male; Methadone; Opioid-Related Disorders; Premedication; Self Administration; Substa | 1982 |
Lofexidine blocks acute opiate withdrawal.
Topics: Antihypertensive Agents; Clonidine; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawa | 1982 |
Methodology for assessing agents that suppress methadone withdrawal: a study of baclofen.
Topics: Adult; Baclofen; Double-Blind Method; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders | 1982 |
Differential motor and state functioning in newborns of women on methadone.
Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pregnancy; | 1982 |
The effects of perinatal addiction on pulmonary function in the newborn.
Topics: Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lung; M | 1982 |
Clonidine in opiate withdrawal.
Topics: Clonidine; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1983 |
The emergence of maternal drug addiction as a problem in Ireland 1981.
Topics: Adolescent; Adult; Cesarean Section; Female; Heroin; Humans; Infant, Newborn; Ireland; Male; Materna | 1983 |
Pentazocine and tripelennamine ('T's and blue's'): effects on the fetus and neonate.
Topics: Adult; Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Opioid-Related | 1983 |
Excretion of catecholamine metabolites during methadone maintenance and withdrawal.
Topics: Adult; Epinephrine; Female; Heroin Dependence; Humans; Male; Metanephrine; Methadone; Methoxyhydroxy | 1983 |
Effect of the hypnotic flurazepam on the sleep of pentazocine and heroin addicts during withdrawal.
Topics: Adolescent; Adult; Flurazepam; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Pentazocine; | 1983 |
Investigation of 89 children born by drug-dependent mothers. I. Neonatal course.
Topics: Adult; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Infant, Small | 1983 |
Investigation of 89 children born by drug-dependent mothers. II. Follow-up 1-10 years after birth.
Topics: Adult; Child; Child Behavior Disorders; Child, Institutionalized; Child, Preschool; Female; Follow-U | 1983 |
When a narcotic addict is hospitalized.
Topics: Heroin Dependence; Hospitalization; Humans; Inactivation, Metabolic; Methadone; Opioid-Related Disor | 1980 |
The use of clonidine in detoxification from opiates.
Topics: Clonidine; Double-Blind Method; Humans; Methadone; Narcotics; Placebos; Substance Withdrawal Syndrom | 1980 |
Clonidine suppresses the opioid abstinence syndrome without clonidine-withdrawal symptoms: a blind inpatient study.
Topics: Adult; Clonidine; Double-Blind Method; Female; Humans; Male; Methadone; Opioid-Related Disorders; Su | 1980 |
Opiate withdrawal syndrome: acute and protracted aspects.
Topics: Humans; Methadone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Substance Withdrawal S | 1981 |
Endorphin levels in opioid-dependent human subjects: a longitudinal study.
Topics: Adult; Endorphins; Humans; Male; Methadone; Middle Aged; Naltrexone; Opioid-Related Disorders; Subst | 1982 |
Methadone treatment of pentazocine abuse.
Topics: Female; Humans; Methadone; Middle Aged; Pentazocine; Substance Withdrawal Syndrome; Substance-Relate | 1982 |
Effect of prior narcotic addiction on response to treatment of alcoholism.
Topics: Adolescent; Adult; Aged; Aging; Alcoholism; Female; Heroin Dependence; Humans; Male; Marriage; Metha | 1980 |
[Acupuncture in the heroin withdrawal syndrome].
Topics: Acupuncture Therapy; Adolescent; Adult; Heroin Dependence; Humans; Methadone; Substance Withdrawal S | 1982 |
[Drug withdrawal syndrome in the neonate].
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Psychotropic Drugs; Substance | 1982 |
Heroin addict responses to six weeks of detoxification with LAAM.
Topics: Adult; Heroin; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Patient Dropouts; Socia | 1982 |
Psychosis in the opioid addicted patient: assessment and treatment.
Topics: Adult; Chlorpromazine; Diagnosis, Differential; Double-Blind Method; Haloperidol; Heroin Dependence; | 1982 |
Outpatient opiate detoxification with clonidine.
Topics: Ambulatory Care; Clonidine; Double-Blind Method; Drug Therapy, Combination; Heroin Dependence; Human | 1982 |
Methadone outcome studies: is it more than the methadone?
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Met | 1982 |
Polydrug- and methadone-addicted newborns: a continuum of impairment?
Topics: Abnormalities, Drug-Induced; Birth Weight; Child Behavior; Female; Heroin Dependence; Humans; Infant | 1982 |
Infants born to narcotic-addicted mothers.
Topics: Child Development; Female; Heroin; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Metha | 1982 |
Lofexidine in abrupt methadone withdrawal.
Topics: Clonidine; Humans; Male; Methadone; Substance Withdrawal Syndrome | 1982 |
Effects of methadone on thyroid function in mother, fetus, and newborn.
Topics: Adolescent; Adult; Age Factors; Female; Fetal Blood; Humans; Infant, Newborn; Infant, Newborn, Disea | 1980 |
Suppression of withdrawal jumping: comparison of narcotic tolerance and dependence.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Male; Methadone; Mice; Mice, Inbr | 1980 |
Narcotic abstinence in dependent rats: EEG and behavioral correlates.
Topics: Animals; Behavior, Animal; Electroencephalography; Female; Humans; Methadone; Methadyl Acetate; Morp | 1980 |
Opiate withdrawal in utero increases neonatal morbidity in the rat.
Topics: Animals; Drug Tolerance; Embryo Implantation; Female; Fetal Death; Humans; Litter Size; Methadone; M | 1981 |
Prenatal withdrawal from opiates interferes with hatching of otherwise viable chick fetuses.
Topics: Animals; Chick Embryo; Humans; Methadone; Methadyl Acetate; Naloxone; Opioid-Related Disorders; Subs | 1981 |
Morphine challenges in levo-alpha-acetylmethadol (LAAM) post-addict rats.
Topics: Animals; Female; Humans; Methadone; Methadyl Acetate; Morphine; Rats; Sleep; Substance Withdrawal Sy | 1981 |
Withdrawal-like symptoms in young and adult rats maternally exposed to methadone.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Body Temperature Regulation; Body Weight; | 1981 |
Addictive behavior.
Topics: Conditioning, Psychological; Dose-Response Relationship, Drug; Humans; Legislation as Topic; Methado | 1980 |
[Neonatal withdrawal syndrome 2 cases of newborn infants of drug-addicted mothers].
Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Pregnancy; Substance Withdrawa | 1980 |
Phenytoin-induced methadone withdrawal.
Topics: Adult; Drug Administration Schedule; Drug Interactions; Humans; Male; Methadone; Phenytoin; Pyrrolid | 1981 |
Clonidine for narcotic withdrawal.
Topics: Clonidine; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1981 |
CSF-endorphins in heroin addicts during methadone maintenance and during withdrawal.
Topics: Adult; Endorphins; Female; Heroin Dependence; Humans; Male; Methadone; Radioligand Assay; Substance | 1981 |
Narcotic withdrawal in children under intense care therapy.
Topics: Child; Child, Preschool; Critical Care; Female; Humans; Male; Methadone; Narcotics; Respiration, Art | 1981 |
The clinical use of clonidine in outpatient detoxification from opiates.
Topics: Clonidine; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Methadone; Naltrexone; Opioi | 1981 |
The Neonatal Narcotic Withdrawal Index: a device for the improvement of care in the abstinence syndrome.
Topics: Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Opium; Pregnancy; Psy | 1981 |
Opiate detoxification with lofexidine.
Topics: Clonidine; Humans; Methadone; Norepinephrine; Substance Withdrawal Syndrome; Time Factors | 1981 |
Relationship of thyroid hormone levels to the severity of the narcotic withdrawal syndrome.
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Pregnancy; Prospective | 1981 |
[Newborn neonatal drug-withdrawal syndrome].
Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methadone; Opiu | 1981 |
Effect of methadone dosage on clonidine detoxification efficacy.
Topics: Clonidine; Double-Blind Method; Humans; Male; Methadone; Opioid-Related Disorders; Substance Withdra | 1980 |
[Jaundice in the newborn infant of a "poly-drug-dependent" mother. Heroin and methadone, G6PDH deficiency and antagonism in the enzymatic modulation].
Topics: Adult; Drug Antagonism; Female; Glucosephosphate Dehydrogenase Deficiency; Heroin Dependence; Humans | 1980 |
Clinical effects of beta-endorphin infusions.
Topics: Adult; Behavior; Depression; Double-Blind Method; Endorphins; Female; Heart Rate; Hemodynamics; Huma | 1980 |
T's and blues. Abuse of pentazocine and tripelennamine.
Topics: Humans; Injections, Intravenous; Methadone; Pentazocine; Substance Withdrawal Syndrome; Substance-Re | 1980 |
Clonidine for opiate detoxification: outpatient clinical trials.
Topics: Ambulatory Care; Clonidine; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Methadone; | 1980 |
Addiction to Distalgesic (dextropropoxyphene)
Topics: Dextropropoxyphene; Humans; Methadone; Substance Withdrawal Syndrome | 1980 |
Early growth patterns of methadone-addicted infants.
Topics: Adult; Female; Follow-Up Studies; Growth; Humans; Infant, Newborn; Methadone; Pregnancy; Substance W | 1980 |
From IM morphine to PO methadone.
Topics: Adult; Heroin Dependence; Humans; Male; Methadone; Morphine; Substance Withdrawal Syndrome | 1980 |
Conditioned responses to drug-related stimuli: is context crucial?
Topics: Adult; Conditioning, Classical; Humans; Male; Methadone; Narcotics; Opioid-Related Disorders; Recurr | 1995 |
Subjective and objective symptoms in relation to plasma methadone concentration in methadone patients.
Topics: Adult; Female; Humans; Male; Methadone; Opioid-Related Disorders; Regression Analysis; Substance Wit | 1995 |
Ondansetron and opiate craving. A novel pharmacological approach to addiction.
Topics: Female; Humans; Male; Methadone; Narcotics; Ondansetron; Substance Withdrawal Syndrome; Substance-Re | 1995 |
Clinical efficacy of gamma-hydroxybutyric acid in treatment of opiate withdrawal.
Topics: Adult; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Neurologic Examination | 1994 |
Methadone anonymous: a 12-step program. Reducing the stigma of methadone use.
Topics: Adult; Alcoholics Anonymous; Alcoholism; Comorbidity; Female; Heroin Dependence; Humans; Internal-Ex | 1994 |
Methadone withdrawal psychosis.
Topics: Adult; Female; Follow-Up Studies; Haloperidol; Humans; Male; Methadone; Middle Aged; Opioid-Related | 1995 |
Buprenorphine effects in methadone-maintained volunteers: effects at two hours after methadone.
Topics: Adult; Buprenorphine; Humans; Male; Methadone; Middle Aged; Naloxone; Opioid-Related Disorders; Psyc | 1995 |
[Benzodiazepines and methadone: a dangerous combination?].
Topics: Adult; Benzodiazepines; Drug Interactions; Humans; Methadone; Receptors, GABA-A; Substance Withdrawa | 1994 |
[Indications for benzodiazepines in the care of drug addicts].
Topics: Anti-Anxiety Agents; Benzodiazepines; Drug Prescriptions; France; Humans; Methadone; Substance Withd | 1994 |
[Are maintenance substitution practices indicated in the framework of health care of drug addicts?].
Topics: Buprenorphine; Clinical Trials as Topic; Heroin; Heroin Dependence; Humans; Methadone; Narcotics; Qu | 1994 |
[Clinical assessment of physical dependence potential of dihydroetorphine hydrochloride (DHE)].
Topics: Administration, Sublingual; Adolescent; Adult; Analgesics, Opioid; Etorphine; Female; Heroin; Heroin | 1994 |
Outpatient therapy of iatrogenic drug dependency following prolonged sedation in the pediatric intensive care unit.
Topics: Child; Female; Fentanyl; Humans; Iatrogenic Disease; Infant; Lorazepam; Male; Methadone; Midazolam; | 1994 |
Medical mismanagement in public methadone programs.
Topics: Adult; Community Mental Health Services; Dose-Response Relationship, Drug; Heroin Dependence; Humans | 1994 |
Medical mismanagement in public methadone programs.
Topics: Attitude of Health Personnel; Community Mental Health Services; Humans; Methadone; Opioid-Related Di | 1994 |
Methadone treatment of opioid withdrawal in intensive care patients.
Topics: Adult; Humans; Intensive Care Units; Methadone; Narcotics; Substance Withdrawal Syndrome; Ventilator | 1993 |
Phases of treatment: a practical approach to methadone maintenance treatment.
Topics: Combined Modality Therapy; Health Care Rationing; Heroin Dependence; Humans; Long-Term Care; Methado | 1994 |
[Withdrawal treatment of drug dependent patients with the aim of achieving abstinence].
Topics: Adolescent; Adult; Ambulatory Care; Female; Heroin Dependence; Humans; Illicit Drugs; Length of Stay | 1994 |
The acute effects of a rapid medical detoxification upon dysphoria and other psychopathology experienced by heroin abusers.
Topics: Adult; Cocaine; Comorbidity; Depressive Disorder; Heroin Dependence; Hospitalization; Humans; Male; | 1994 |
[A case from practice (238). Benzodiazepine withdrawal delirium in a multidrug addict].
Topics: Adult; Benzodiazepines; Diagnosis, Differential; Humans; Male; Marijuana Abuse; Methadone; Substance | 1994 |
Poppy tea dependence.
Topics: Adult; Codeine; Dose-Response Relationship, Drug; Humans; Male; Methadone; Opioid-Related Disorders; | 1993 |
[Evaluation of a drug withdrawal unit].
Topics: Adolescent; Adult; Female; Follow-Up Studies; Heroin Dependence; Humans; Length of Stay; Male; Metha | 1993 |
Organic mood syndrome associated with detoxification from methadone maintenance.
Topics: Adult; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Mo | 1993 |
[EMG abnormalities in REM sleep of addicted patients].
Topics: Adolescent; Adult; Alcohol Withdrawal Delirium; Alcoholism; Electromyography; Female; Humans; Male; | 1993 |
[Beta-carbolines (harman/norharman) are increased in heroin dependent patients].
Topics: Adult; Carbolines; Female; Harmine; Heroin Dependence; Humans; Male; Methadone; Substance Withdrawal | 1993 |
Availability of reliable serum methadone determination for management of symptomatic patients.
Topics: Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Male; Methadone; Middle A | 1995 |
Reliability of sequential naloxone challenge tests.
Topics: Adrenocorticotropic Hormone; Adult; Blood Pressure; Humans; Injections, Intravenous; Male; Methadone | 1995 |
Radioimmunoassay of drugs of abuse in hair. Part 2: The determination of methadone in the hair of known drug users.
Topics: Chemistry Techniques, Analytical; Female; Hair; Humans; Illicit Drugs; Inactivation, Metabolic; Male | 1995 |
Abnormal cerebral metabolism in polydrug abusers during early withdrawal: a 31P MR spectroscopy study.
Topics: Adult; Brain; Case-Control Studies; Cocaine; Heroin Dependence; Humans; Magnetic Resonance Imaging; | 1996 |
Influence of plasma-protein binding on analgesic effect of methadone in rats with spontaneous withdrawal.
Topics: Analgesics, Opioid; Animals; Male; Methadone; Morphine; Narcotics; Orosomucoid; Pain Measurement; Pr | 1996 |
Inadequate treatment of opioid dependence due to society's attitudes and beliefs.
Topics: Analgesics, Opioid; Behavior Therapy; Health Knowledge, Attitudes, Practice; Humans; Methadone; Opio | 1996 |
Methadone use during pregnancy.
Topics: Animals; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; Pregna | 1995 |
[Depressive disorders in management of drug dependent patients. Methadone maintenance].
Topics: Adult; Antidepressive Agents; Comorbidity; Depressive Disorder; Drug Interactions; Drug Therapy, Com | 1995 |
Abstinence symptomatology associated with cessation of chronic cocaine abuse among methadone-maintained patients.
Topics: Adult; Chronic Disease; Cocaine; Ethanol; Female; Humans; Male; Methadone; Substance Withdrawal Synd | 1996 |
Craving despite extremely high methadone dosage.
Topics: Dose-Response Relationship, Drug; Humans; Male; Metabolic Clearance Rate; Methadone; Middle Aged; Mo | 1996 |
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
Topics: Analgesics; Animals; Disulfides; Drug Combinations; Enkephalins; Indoles; Male; Meglumine; Methadone | 1996 |
Methadone maintenance and tuberculosis treatment.
Topics: Adult; Antibiotics, Antitubercular; Female; Humans; Methadone; Opioid-Related Disorders; Rifampin; S | 1996 |
Lack of a pharmacologic interaction between rifabutin and methadone in HIV-infected former injecting drug users.
Topics: Adult; AIDS-Related Opportunistic Infections; Dose-Response Relationship, Drug; Drug Interactions; D | 1996 |
The induction and quantitation of methadone dependence in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Drinking; Emulsions; Female; Methadone; Naloxone; Opioid- | 1996 |
[Opiate withdrawal in anesthesia (forced narcotic withdrawal, "turbo withdrawal") in narcotic dependence. Changes in withdrawal treatment--wishes and reality].
Topics: Adult; Anesthesia, General; Animals; Codeine; Female; Heroin Dependence; Humans; Male; Methadone; Na | 1996 |
Early recurrence of withdrawal symptoms under phenytoin and chronic alcohol use.
Topics: Adult; Alcoholism; Epilepsy, Generalized; Humans; Male; Methadone; Opioid-Related Disorders; Phenyto | 1997 |
Abstinence fear in methadone maintenance withdrawal: a possible obstacle for getting off methadone.
Topics: Adult; Analysis of Variance; Fear; Female; Heroin Dependence; Humans; Male; Methadone; Psychometrics | 1997 |
Subjective sleep-wake parameters in treatment-seeking opiate addicts.
Topics: Adult; Circadian Rhythm; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Pat | 1997 |
Patient perceptions of psychological and physiological withdrawal symptoms and positive factors associated with gradual withdrawal from methadone maintenance treatment: a prospective study.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Methado | 1997 |
l-alpha-Acetylmethadol, l-alpha-acetyl-N-normethadol and l-alpha-acetyl-N,N-dinormethadol: comparisons with morphine and methadone in suppression of the opioid withdrawal syndrome in the dog.
Topics: Analgesics, Opioid; Animals; Dogs; Dose-Response Relationship, Drug; Methadone; Methadyl Acetate; Mo | 1997 |
[Drug problem should not be penalized. Interview by Dr. med. vet. Susanne Kammerer].
Topics: Combined Modality Therapy; Heroin Dependence; Humans; Methadone; Socialization; Substance Withdrawal | 1997 |
Regulation of G protein-coupled receptor kinase 2 in brains of opiate-treated rats and human opiate addicts.
Topics: Adolescent; Adult; Animals; beta-Adrenergic Receptor Kinases; Brain; Cyclic AMP-Dependent Protein Ki | 1998 |
Patterns of symptom complaints in methadone maintenance patients.
Topics: Adult; Cross-Sectional Studies; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Rela | 1997 |
Neonatal withdrawal following pre- and postnatal exposure to methadone in the rat.
Topics: Animals; Animals, Newborn; Behavior, Animal; Female; Humans; Infant, Newborn; Male; Methadone; Motor | 1998 |
Pathological regional cerebral blood flow in opiate-dependent patients during withdrawal: a HMPAO-SPECT study.
Topics: Adult; Basal Ganglia; Brain; Cerebral Cortex; Cerebrovascular Circulation; Female; Heroin Dependence | 1998 |
Opioid detoxification in pregnancy.
Topics: Adult; Analgesics; Analgesics, Opioid; Chi-Square Distribution; Clonidine; Drug Therapy, Combination | 1998 |
[Ambulatory opiate withdrawal].
Topics: Ambulatory Care; Buprenorphine; Hospitalization; Humans; Methadone; Narcotics; Opioid-Related Disord | 1998 |
Plasma methadone concentrations as an indicator of opioid withdrawal symptoms and heroin use in a methadone maintenance program.
Topics: Adult; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Male; Methadone; Middle | 1998 |
Ultra-rapid opiate detoxification using deep sedation with oral midazolam: short and long-term results.
Topics: Administration, Oral; Adolescent; Adult; Anesthesia, General; Clonidine; Drug Therapy, Combination; | 1998 |
Altered plasma and brain disposition and pharmacodynamics of methadone in abstinent rats.
Topics: Analgesics, Opioid; Animals; Brain; Male; Methadone; Morphine; Rats; Rats, Sprague-Dawley; Substance | 1999 |
Continued heroin use during methadone treatment: relationships between frequency of use and reasons reported for heroin use.
Topics: Adult; Female; Heroin Dependence; Humans; Male; Methadone; Narcotics; Periodicity; Substance Withdra | 1999 |
Methadone withdrawal when starting an antiretroviral regimen including nevirapine.
Topics: Adult; Anti-HIV Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; E | 1999 |
Hyperphagia in neonates withdrawing from methadone.
Topics: Adult; Birth Weight; Body Weight; Female; Humans; Hyperphagia; Incidence; Infant, Newborn; Linear Mo | 1999 |
[Potential opiate withdrawal syndrome after ritonavir administration in a patient treated with methadone].
Topics: Adult; Analgesics, Opioid; HIV Protease Inhibitors; Humans; Male; Methadone; Ritonavir; Substance Wi | 1999 |
Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone.
Topics: Adult; Anti-HIV Agents; Drug Interactions; Female; HIV Infections; Humans; Male; Methadone; Middle A | 1999 |
Nevirapine-induced withdrawal symptoms in HIV patients on methadone maintenance programme: an alert.
Topics: Adult; Anti-HIV Agents; Drug Interactions; HIV Infections; Humans; Methadone; Narcotics; Nevirapine; | 1999 |
Steady-state pharmacokinetics and pharmacodynamics in methadone maintenance patients: comparison of those who do and do not experience withdrawal and concentration-effect relationships.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Pa | 1999 |
Is naltrexone a cure for heroin dependence?
Topics: Australia; Heroin Dependence; Humans; Methadone; Naltrexone; Narcotic Antagonists; Pilot Projects; S | 1999 |
Emergency therapeutical approach simulating ultrarapid opioid detoxification in methadone withdrawal precipitated by erroneous administration of naltrexone.
Topics: Adult; Anesthetics, Intravenous; Emergencies; Humans; Male; Methadone; Naltrexone; Narcotic Antagoni | 1999 |
Serendipitous rapid detoxification from opiates: the importance of time-dependent processes.
Topics: Adult; Heroin Dependence; Humans; Male; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Subs | 1999 |
A therapeutic use of the methadone fluvoxamine drug interaction.
Topics: Adult; Drug Interactions; Female; Fluvoxamine; Humans; Methadone; Narcotics; Opioid-Related Disorder | 1999 |
Decreased methadone effect after ritonavir initiation.
Topics: Analgesics, Opioid; Anti-HIV Agents; Diagnosis, Differential; Drug Interactions; Drug Therapy, Combi | 2000 |
Alpha 1-acid glycoprotein (AAG) and serum protein binding of methadone in heroin addicts with abstinence syndrome.
Topics: Adult; Blood Proteins; Heroin Dependence; Humans; Methadone; Narcotics; Orosomucoid; Protein Binding | 2000 |
Safety, efficacy, and long-term results of a modified version of rapid opiate detoxification under general anaesthesia: a prospective study in methadone, heroin, codeine and morphine addicts.
Topics: Adult; Anesthesia, General; Codeine; Female; Heroin Dependence; Humans; Male; Methadone; Morphine De | 2000 |
[Nevirapine induces abstinence symptoms in patients on a methadone maintenance program with HIV infection].
Topics: Adult; Analysis of Variance; Anti-HIV Agents; Chronic Disease; Drug Interactions; Drug Therapy, Comb | 2000 |
[Methadone withdrawal syndrome induced by nevirapine].
Topics: Adult; Female; Humans; Methadone; Nevirapine; Reverse Transcriptase Inhibitors; Substance Withdrawal | 2000 |
Nevirapine and methadone withdrawal.
Topics: Anti-HIV Agents; Drug Interactions; HIV Seropositivity; Humans; Methadone; Narcotics; Nevirapine; Su | 1999 |
Efavirenz decreases methadone blood concentrations.
Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Interactions; Female; HIV Infecti | 2000 |
Methadone withdrawal symptoms with nevirapine and efavirenz.
Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Interactions; HIV Infections; Hum | 2000 |
Comment: opiate withdrawal symptoms induced by antiretroviral drugs.
Topics: Alkynes; Analgesics, Opioid; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Humans; Methadone; Nevira | 2000 |
Methadone detoxification of tramadol dependence.
Topics: Acute Disease; Dose-Response Relationship, Drug; Female; Humans; Methadone; Middle Aged; Opioid-Rela | 2000 |
The processing of automatic thoughts of drug use and craving in opiate-dependent individuals.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Behavior, Addictive; Female; Humans; Male; Mental P | 2000 |
[Evolution and update of detoxification techniques for opiate addicts].
Topics: Animals; Buprenorphine; Humans; Methadone; Naloxone; Naltrexone; Narcotic Antagonists; Opioid-Relate | 2000 |
Withdrawal from methadone maintenance treatment: prognosis and participant perspectives.
Topics: Adult; Australia; Behavior, Addictive; Cross-Sectional Studies; Heroin Dependence; Humans; Methadone | 2001 |
Psychosis after ultrarapid opiate detoxification.
Topics: Alprazolam; Benzodiazepines; Drug Administration Schedule; Female; Humans; Hydrocodone; Methadone; M | 2001 |
Drugs of abuse--an analysis based on cases from the Kraków Department of Clinical Toxicology of Jagiellonian University College of Medicine in 1997-2000.
Topics: Adhesives; Adolescent; Adult; Age Distribution; Comorbidity; Drug Overdose; Female; Humans; Illicit | 2001 |
Effect of perinatal buprenorphine exposure on development in the rat.
Topics: Animals; Animals, Newborn; Buprenorphine; Drinking; Eating; Female; Growth; Litter Size; Methadone; | 2001 |
[Opioid addiction: P300 assessment in treatment by methadone substitution].
Topics: Adult; Discrimination, Psychological; Dose-Response Relationship, Drug; Event-Related Potentials, P3 | 2001 |
Narcotic withdrawal syndrome following gastric bypass--a difficult diagnosis.
Topics: Adult; Behavior, Addictive; Diagnosis, Differential; Female; Gastric Bypass; Humans; Methadone; Opio | 2001 |
[Subjective wellbeing in heroin withdrawal. With methadone the patient feels better].
Topics: Administration, Oral; Heroin Dependence; Humans; Methadone; Neurologic Examination; Quality of Life; | 2001 |
Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal.
Topics: Analgesics, Opioid; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Drug Tolerance; Endocyt | 2001 |
Enteral methadone to expedite fentanyl discontinuation and prevent opioid abstinence syndrome in the PICU.
Topics: Adolescent; Analgesics, Opioid; Child; Fentanyl; Humans; Intensive Care Units, Pediatric; Methadone; | 2001 |
[Subjective wellbeing and somatic markers in methadone substitution. Evaluation of 61 heroin addicts].
Topics: Adult; Female; Heroin Dependence; Humans; Male; Methadone; Neurologic Examination; Quality of Life; | 2001 |
Withdrawal from methadone maintenance treatment. Reasons for not trying to quit methadone.
Topics: Adult; Decision Making; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Subs | 2002 |
Undefined duration of opiate withdrawal induced by efavirenz in drug users with HIV infection and undergoing chronic methadone treatment.
Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Interactions; HIV Infections; Humans; Ki | 2002 |
[Persistent injecting practices in subjects on methadone or buprenorphine maintenance therapy. A study of 600 cases].
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Male; Methadone; Opioid-Related Disorders; | 2001 |
High-dose methadone produces superior opioid blockade and comparable withdrawal suppression to lower doses in opioid-dependent humans.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Dose-Response Relationship, Drug; Double-Blind Meth | 2002 |
[Opioid treatment of pain in angina pectoris].
Topics: Aged; Analgesics, Opioid; Angina, Unstable; Humans; Male; Methadone; Morphine; Substance Withdrawal | 2002 |
[Detoxication of heroin addicts in the area of Genoa].
Topics: Adolescent; Adult; Amino Acids; Clonidine; Diazepam; Female; Fructose; Heroin Dependence; Humans; Ma | 1979 |
Human sleep and EEG through a cycle of methadone dependence.
Topics: Adult; Brain Diseases; Dreams; Electroencephalography; Fourier Analysis; Heroin Dependence; Humans; | 1975 |
Editorial: Methadone maintenance.
Topics: Administration, Oral; Drug and Narcotic Control; Heroin Dependence; Humans; Methadone; Substance Wit | 1975 |
Letter: Treatment of accidental naltrexone-induced withdrawal.
Topics: Adult; Humans; Hydromorphone; Male; Methadone; Naloxone; Naltrexone; Substance Withdrawal Syndrome | 1976 |
Management of surgical problems in patients on methadone maintenance.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Cocaine; Female; Heroin Dependence; Humans; Hydromorph | 1976 |
Drug addiction in pregnancy.
Topics: Adult; Female; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newbor | 1976 |
Rifampicin and methadone withdrawal.
Topics: Adult; Bronchopneumonia; Drug Interactions; Female; Humans; Methadone; Rifampin; Substance Withdrawa | 1977 |
Late withdrawal symptoms in babies born to methadone addicts.
Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal | 1977 |
Clonidine in opiate withdrawal.
Topics: Clonidine; Humans; Male; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders | 1978 |
Dependence in rats after one injection of heroin-, LAAM- or hydromorphone-zinc tannate.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Heroin; Heroin Dependence; Humans; Hydromo | 1979 |
Animal-human correlates of narcotic dependence: a brief review.
Topics: Animals; Behavior Therapy; Conditioning, Operant; Disease Models, Animal; Dogs; Drug Tolerance; Hapl | 1978 |
The SAODAP cooperative studies of LAAM: unblinded comparison with methadone.
Topics: Drug Administration Schedule; Government Agencies; Heroin Dependence; Humans; Methadone; Methadyl Ac | 1978 |
The abstinence phobia.
Topics: Adaptation, Psychological; Anxiety; Heroin; Heroin Dependence; Humans; Methadone; Phobic Disorders; | 1979 |
Clonidine detoxification: a fourteen-day protocol for rapid opiate withdrawal.
Topics: Clonidine; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome; Time Factors | 1979 |
Clonidine hydrochloride: a nonopiate treatment for opiate withdrawal.
Topics: Clonidine; Humans; Methadone; Naltrexone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1979 |
Changes in brain cyclic AMP metabolism and acetylcholine and dopamine during narcotic dependence and withdrawal.
Topics: Acetylcholine; Acetylcholinesterase; Adenylyl Cyclases; Animals; Brain; Cerebral Cortex; Corpus Stri | 1975 |
Human sleep during chronic morphine intoxication.
Topics: Adult; Alpha Rhythm; Arousal; Delta Rhythm; Drug Tolerance; Humans; Male; Methadone; Morphine; Morph | 1975 |
1-alpha-acetylmethadol (LAAM), methadone and morphine abstinence in dependent rats: EEG and behavioral correlates.
Topics: Animals; Behavior, Animal; Electroencephalography; Electromyography; Female; Humans; Methadone; Meth | 1977 |
Sustained ingestion of methadone and the sleep of monkeys.
Topics: Animals; Haplorhini; Humans; Macaca; Methadone; Sleep; Sleep, REM; Substance Withdrawal Syndrome; Ti | 1978 |
Update of naltrexone treatment.
Topics: Adult; Conditioning, Psychological; Female; Humans; Male; Methadone; Naloxone; Naltrexone; Narcotics | 1978 |
Naltrexone in the treatment of opiate dependence.
Topics: Adolescent; Adult; Follow-Up Studies; Forecasting; Heroin Dependence; Humans; Male; Methadone; Nalox | 1978 |
[Detoxification practice in heroin addicts].
Topics: Adult; Aftercare; Biotransformation; Female; Heroin Dependence; Humans; Inactivation, Metabolic; Mal | 1979 |
Spontaneous vs. naloxone-induced abstinence in dependent rats self-administering L-alpha-acetylmethadol (LAAM) or morphine.
Topics: Animals; Female; Humans; Methadone; Methadyl Acetate; Morphine Dependence; Naloxone; Rats; Self Admi | 1979 |
Changes in adrenocorticotropic hormone (ACTH) and cortisol levels in drug addicts treated by a new and rapid detoxification procedure using acupuncture and naloxone.
Topics: Acupuncture Therapy; Adrenocorticotropic Hormone; Adult; Cyclic AMP; Electric Stimulation Therapy; E | 1979 |
A comparison of narcotic analgesics with neuroleptics on behavioral measures of dopaminergic activity.
Topics: Aggression; Amphetamine; Analgesics, Opioid; Animals; Apomorphine; Behavior, Animal; Brain; Cataleps | 1975 |
Pentazocine abuse and problems of withdrawal.
Topics: Antipsychotic Agents; Confusion; Delirium; Dose-Response Relationship, Drug; Female; Humans; Hypnoti | 1975 |
The use of diphenoxylate hydrochloride (Lomotil) in the management of the minor withdrawal syndrome during methadone detoxification: a clinical report.
Topics: Adult; Diphenoxylate; Humans; Isonipecotic Acids; Male; Methadone; Substance Withdrawal Syndrome; Su | 1977 |
Detoxification from methadone maintenance in a family-oriented program.
Topics: Adult; Family Therapy; Female; Humans; Male; Methadone; Substance Withdrawal Syndrome; Substance-Rel | 1977 |
Dental implications of narcotic addiction.
Topics: Dental Caries; Diet; Endocarditis; Hepatitis B; Humans; Methadone; Narcotics; Periodontal Diseases; | 1978 |
Management of pregnant drug-dependent women.
Topics: Family Therapy; Female; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant | 1978 |
Therapeutic detoxification of adolescent heroin addicts.
Topics: Adolescent; Age Factors; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; New | 1978 |
Perinatal addiction: outcome and management.
Topics: Abruptio Placentae; Apgar Score; Breech Presentation; Cesarean Section; Counseling; Female; Fetal Gr | 1977 |
Biofeedback application to drug addiction in the University of Colorado drug rehabilitation program.
Topics: Anxiety; Biofeedback, Psychology; Colorado; Costs and Cost Analysis; Electromyography; Heroin Depend | 1978 |
Effects of methadone and morphine maintenance on drug-seeking behavior in the dog.
Topics: Animals; Behavior, Animal; Dogs; Haplorhini; Humans; Methadone; Morphine; Papio; Rats; Self Administ | 1977 |
The effect of methadone on hypophyseal and peripheral glandular hormones during withdrawal.
Topics: Adult; Estrogens; Glucose Tolerance Test; Gonadotropin-Releasing Hormone; Hormones; Humans; Hydrocor | 1977 |
Opiates, catecholamines, behavior, and mood.
Topics: Adult; Behavior; Catecholamines; Emotions; Heroin; Humans; Male; Methadone; Methoxyhydroxyphenylglyc | 1978 |
Increased serum methadone levels in humans during naloxone-precipitated withdrawal [proceedings].
Topics: Humans; Methadone; Naloxone; Substance Withdrawal Syndrome | 1979 |
Decreased serum prolactin in opiate withdrawal and dopaminergic hyperactivity.
Topics: Clonidine; Humans; Methadone; Narcotics; Prolactin; Receptors, Dopamine; Substance Withdrawal Syndro | 1979 |
Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users.
Topics: Amphetamine; Cocaine; Diazepam; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Infant, | 1979 |
Rapid opiate detoxification: clinical evidence of antidepressant and antipanic effects of opiates.
Topics: Adult; Anxiety; Clonidine; Depression; Drug Therapy, Combination; Fear; Humans; Imipramine; Male; Me | 1979 |
[The effect of heroin and methadone on pregnancy and the newborn infant].
Topics: Female; Fetus; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Labor, | 1979 |
Perinatal drug abuse.
Topics: Amphetamines; Barbiturates; Cannabis; Cocaine; Female; Fetal Alcohol Spectrum Disorders; Heroin Depe | 1979 |
[Opium abuse in Sweden].
Topics: Heroin Dependence; Humans; Inactivation, Metabolic; Methadone; Opium; Substance Withdrawal Syndrome; | 1979 |
Urinary excretion of methadone during neonatal withdrawal: clinical application.
Topics: Age Factors; Dose-Response Relationship, Drug; Hemagglutination Inhibition Tests; Humans; Infant, Ne | 1979 |
Pain perception in drug-free and in methadone-maintained human ex-addicts.
Topics: Adult; Blood Pressure; Cold Temperature; Female; Humans; Informed Consent; Male; Methadone; Pain; Su | 1979 |
Outcomes of pregnancy for addicts receiving comprehensive care.
Topics: Adult; Bilirubin; Birth Weight; Comprehensive Health Care; Female; Gestational Age; Humans; Infant, | 1979 |
Methadone exposure in utero: developmental status at one and two years of age.
Topics: Aging; Female; Growth; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intelligence Test | 1979 |
Sudden unexpected death in infants of narcotic-dependent mothers.
Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Male; Maternal-Fetal | 1978 |
Tolerance, dependence and lethality in morphine-dependent mice after repeated oral administration of methadone.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Implants; Humans; Male; Methad | 1978 |
Narcotic abuse in pregnancy.
Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pre | 1979 |
Detoxification from methadone maintenance: the state of the art.
Topics: Follow-Up Studies; Heroin Dependence; Hospitalization; Humans; Methadone; Patient Participation; Psy | 1977 |
[Morphine intoxication and abstinence].
Topics: Dextropropoxyphene; Drug Tolerance; Heroin; Heroin Dependence; Humans; Methadone; Morphine; Morphine | 1977 |
Pharmacologic activity of beta-endorphin in man.
Topics: Analgesics; Dose-Response Relationship, Drug; Endorphins; Heroin Dependence; Humans; Methadone; Morp | 1977 |
Factors related to successful retention in methadone maintenance: a review.
Topics: Age Factors; Alcoholism; Dose-Response Relationship, Drug; Educational Status; Employment; Ethnicity | 1977 |
The narcotic-dependent mother: fetal and neonatal consequences.
Topics: Adult; Female; Fetal Death; Fetus; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Inf | 1977 |
Practical psychiatry in medicine. Part 10. Drug abuse and the addictions.
Topics: Amphetamines; Hallucinogens; Humans; Hypnotics and Sedatives; Methadone; Opium; Phencyclidine; Socio | 1978 |
Management of neonatal drug withdrawal.
Topics: Diazepam; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Seizures | 1978 |
beta-endorphin: subjective and objective effects during acute narcotic abstinence in man.
Topics: Adult; Endorphins; Humans; Male; Methadone; Substance Withdrawal Syndrome; Time Factors | 1978 |
Problems pertaining to the care of newborn infants of drug-addicted women.
Topics: Apnea; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Narcotics; P | 1978 |
Psychosocial care of the pregnant narcotic addict.
Topics: Behavior Therapy; Female; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infa | 1978 |
Abuse of amitriptyline.
Topics: Amitriptyline; Depression; Heroin Dependence; Humans; Methadone; Self Medication; Substance Withdraw | 1978 |
Clonidine may relieve opiate withdrawal symptoms.
Topics: Clonidine; Humans; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders | 1978 |
Serum methadone as an aid in managing methadone maintenance patients.
Topics: Adult; Attitude of Health Personnel; Drug Administration Schedule; Female; Heroin Dependence; Humans | 1978 |
Treatment of methadone withdrawal with cerebral electrotherapy (electrosleep).
Topics: Adolescent; Adult; Anxiety; Electronarcosis; Evaluation Studies as Topic; Heroin Dependence; Humans; | 1979 |
Fetal consequences of chronic methadone administration to pregnant rats: methadological problems.
Topics: Animals; Animals, Newborn; Birth Weight; Female; Fetus; Humans; Maternal-Fetal Exchange; Methadone; | 1975 |
Monkey motor stimulation and altered social behavior during chronic methadone administration.
Topics: Animals; Conditioning, Operant; Dominance-Subordination; Dose-Response Relationship, Drug; Feeding B | 1975 |
Observation and treatment of neonatal narcotic withdrawal.
Topics: Diazepam; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New | 1977 |
Conditioned narcotic withdrawal in humans.
Topics: Adult; Conditioning, Classical; Humans; Male; Methadone; Naloxone; Substance Withdrawal Syndrome | 1977 |
Experiences with 118 infants born to narcotic-using mothers. Does a lowered serum-ionized calcium level contribute to the symptoms of withdrawal?
Topics: Calcium; Female; Follow-Up Studies; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, New | 1977 |
Neonatal withdrawal symptoms associated with glutethimide (Doriden) addiction in the mother during pregnancy.
Topics: Female; Glutethimide; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, | 1977 |
Naloxone-precipitated withdrawal: a method for rapid induction onto naltrexone.
Topics: Adult; Drug Administration Schedule; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Met | 1977 |
Opium and heroin addicts in Laos. I. A comparative study.
Topics: Adolescent; Adult; Age Factors; Aged; Costs and Cost Analysis; Ethnicity; Female; Heroin Dependence; | 1977 |
Opium and heroin addicts in Laos. II. A study of matched pairs.
Topics: Adolescent; Adult; Age Factors; Aged; Costs and Cost Analysis; Ethnicity; Female; Heroin Dependence; | 1977 |
Success rate of detoxification from methadone maintenance in an ambulatory care unit.
Topics: Adolescent; Adult; Ambulatory Care; Female; Humans; Male; Methadone; Patient Compliance; Substance W | 1977 |
Methadone maintenance in a patient on chronic hemodialysis.
Topics: Aggression; Humans; Male; Methadone; Middle Aged; Morphine Dependence; Renal Dialysis; Substance Wit | 1977 |
Alcohol and opiate dependence; a review.
Topics: Alcoholism; Humans; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders | 1977 |
Maternal ingested methadone, body fluid methadone, and the neonatal withdrawal syndrome.
Topics: Amniotic Fluid; Body Fluids; Female; Fetal Blood; Fetus; Heroin Dependence; Humans; Infant, Newborn; | 1977 |
Effects of acute and chronic methadone treatment of the uptake of 3H-5-hydroxytryptamine in rat hypothalamus slices.
Topics: Animals; Dextrorphan; Female; Heroin; Humans; Hypothalamus; In Vitro Techniques; Levorphanol; Methad | 1976 |
Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Child, Preschool; Female; Follow-Up Studies; Heroin De | 1976 |
Successful detoxification from methadone maintenance. Follow-up study of 38 patients.
Topics: Alcoholism; Drug Evaluation; Humans; Methadone; Recurrence; Social Adjustment; Substance Withdrawal | 1976 |
Attentuation of precipitated abstinence in methadone-dependent rats by delta9-THC.
Topics: Animals; Cannabis; Dronabinol; Humans; Hypnotics and Sedatives; Methadone; Rats; Research Design; Su | 1976 |
Behavioural concomitants of prenatal addiction to narcotics.
Topics: Child Development; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Feta | 1976 |
Descriptive study of behavior during transition from heroin addict to methadone patient.
Topics: Female; Heroin Dependence; Humans; Life Style; Male; Methadone; Self Disclosure; Social Adjustment; | 1976 |
Alterations in brain endogenous histamine levels in rats after chronic morphine treatment and morphine withdrawal.
Topics: Animals; Body Weight; Brain; Brain Stem; Cerebral Cortex; Histamine; Humans; Male; Methadone; Morphi | 1976 |
Neonatal drug dependence: developmental and bio-cultural considerations.
Topics: Birth Weight; Family Characteristics; Female; Fetus; Humans; Infant Mortality; Infant, Newborn; Infa | 1976 |
Detoxification from methadone maintenance.
Topics: Humans; Methadone; Remission, Spontaneous; Substance Withdrawal Syndrome; Substance-Related Disorder | 1976 |
A clinical experience with LAAM.
Topics: Heroin Dependence; Humans; Methadone; Methadyl Acetate; Self Administration; Substance Withdrawal Sy | 1976 |
Actions and addiction liabilities of alpha-acetylmethadols in man. 1952 [proceedings].
Topics: Adult; Drug Administration Schedule; Humans; Male; Methadone; Methadyl Acetate; Miotics; Morphine De | 1976 |
Levomethadyl acetate: prolonged duration of opioid effects, including cross tolerance to heroin, in man. 1973 [proceedings].
Topics: Adult; Drug Tolerance; Heroin; Heroin Dependence; Humans; Male; Methadone; Methadyl Acetate; Middle | 1976 |
[Therapy of drug dependence in adolescents. Clinical aspects of somatic detoxification].
Topics: Adolescent; Adult; Age Factors; Doxepin; Female; Follow-Up Studies; Humans; Male; Methadone; Piracet | 1976 |
Metabolic disposition of 2-phenylethylamine and the role of depression in methadone-dependent and detoxified patients.
Topics: Adult; Depression; Female; Heroin Dependence; Humans; Male; Methadone; Phenethylamines; Substance Wi | 1976 |
Methadone maintenance treatment of narcotic addiction: a unit of medical care based on over 50,000 patient treatment years.
Topics: Crime; Education; Employment; Heroin Dependence; Humans; Methadone; New York City; Substance Withdra | 1976 |
Relationship of neonatal withdrawal to maternal methadone dose.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Preg | 1976 |
On understanding and treating narcotic dependence: a neuropsychopharmacological perspective.
Topics: Acetylcholine; Catecholamines; Dose-Response Relationship, Drug; Euphoria; Heroin Dependence; Humans | 1975 |
Interactions of narcotics, narcotic antagonists, and ethanol during acute, chronic, and withdrawal states.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Dextrorphan; Drug Interactions; Ethanol; Humans; Levorp | 1976 |
Effect of neurotone therapy during methadone detoxification.
Topics: Adult; Anxiety; Electric Stimulation Therapy; Female; Heroin Dependence; Humans; Male; Methadone; Mi | 1976 |
Pulmonary function studies in ex-heroin users.
Topics: Adult; Airway Obstruction; Female; Follow-Up Studies; Foreign-Body Reaction; Heroin Dependence; Huma | 1975 |
Results of 313 consecutive live births of infants delivered to patients in the New York City Methadone Maintenance Treatment Program.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Drug and Narcotic Control; Female; Fetus; Follow-Up St | 1975 |
Methadone assays in pregnant women and progeny.
Topics: Amniotic Fluid; Chromatography, Gas; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infa | 1975 |
Observations on methadone withdrawal in 16 neonates.
Topics: Adolescent; Adult; Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn | 1975 |
Plasma testosterone levels in heroin addiction and during methadone maintenance.
Topics: Adult; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Radioimmunoassay; Substance Withdraw | 1975 |
Plasma testosterone levels during chronic heroin use and protracted astinence. A study of Hong Kong addicts.
Topics: Adolescent; Adult; Depression, Chemical; Heroin Dependence; Hong Kong; Humans; Male; Methadone; Subs | 1975 |
Ocular absorption of naloxone in narcotic addicts.
Topics: Absorption; Adolescent; Adult; Conjunctiva; Galvanic Skin Response; Humans; Injections, Intravenous; | 1975 |
Fetal stress from methadone withdrawal.
Topics: Adrenal Glands; Amniocentesis; Amniotic Fluid; Epinephrine; Female; Fetus; Heroin Dependence; Humans | 1975 |
Propoxyphene napsylate detoxification.
Topics: Adult; Dextropropoxyphene; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Male; Methad | 1975 |
Guidelines for the management of hospitalized narcotics addicts.
Topics: Analgesia; Drug Administration Schedule; Drug Combinations; Drug Interactions; Female; Heroin; Hospi | 1975 |
Plasma levels and symptom complaints in patients maintained on daily dosage of methadone hydrochloride.
Topics: Blood Proteins; Body Weight; Heroin Dependence; Humans; Infant; Male; Methadone; Protein Binding; Se | 1975 |
Acute management of neonatal addiction.
Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant | 1975 |
Disposition of methadone and its relationship to severity of withdrawal in the newborn.
Topics: Administration, Oral; Chromatography, Gas; Dose-Response Relationship, Drug; Female; Fetal Blood; Ha | 1975 |
A study of factors that influence the severity of neonatal narcotic withdrawal.
Topics: Administration, Oral; Bilirubin; Birth Weight; Body Weight; Dose-Response Relationship, Drug; Enviro | 1975 |
Current concepts in the management of the pregnant opiate addict.
Topics: Administration, Oral; Anesthesia, Conduction; Anesthesia, Obstetrical; Birth Weight; Counseling; Fem | 1975 |
Neurological aspects of perinatal narcotic addiction and methadone treatment.
Topics: Auditory Perception; Autonomic Nervous System; Birth Weight; Central Nervous System Diseases; Child | 1975 |
Part II. Behavioral and electrophysiological characteristics of the addicted neonate.
Topics: Acoustic Stimulation; Arousal; Attention; Birth Weight; Electrophysiology; Evoked Potentials; Female | 1975 |
Neonatal addiction: a two-year study. Part I. Clinical and developmental characteristics of infants of mothers on methadone maintenance.
Topics: Administration, Oral; Age Factors; Attention; Birth Weight; Child Development; Diazepam; Dose-Respon | 1975 |
Differential effects of heroin and methadone on birth weights.
Topics: Birth Weight; Dose-Response Relationship, Drug; Female; Fetus; Gestational Age; Heroin Dependence; H | 1975 |
Cytogenetic risks to the offspring of pregnant addicts.
Topics: Chromosome Aberrations; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Karyotyping; Male | 1975 |
Pharmacological approaches to the treatment of morphine-type dependence.
Topics: Cyclazocine; Drug Therapy, Combination; Drug Tolerance; Humans; Methadone; Morphine Dependence; Nalo | 1975 |
Letter: Treatment of addicts.
Topics: Heroin Dependence; Humans; Methadone; Substance Withdrawal Syndrome | 1975 |
Effect of maternal heroin addiction on 67 liveborn neonates. Withdrawal symptoms, small body size, and small head circumference were frequent findings.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Birth Weight; Blood Glucose; Cephalomet | 1975 |
Blockade by narcotic drugs of naloxone-precipitated jumping in morphine-dependent mice.
Topics: Administration, Oral; Animals; Apomorphine; Behavior, Animal; Codeine; Dextropropoxyphene; Dose-Resp | 1975 |
The effects of methadone on maternal-fetal interactions in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dose-Response Relationship, Drug; Female; Fetal D | 1975 |
Possible role of brain histamine in morphine addiction.
Topics: Animals; Brain; Brain Stem; Cerebral Cortex; Histamine; Humans; Hypothalamus; Male; Methadone; Morph | 1975 |
Methadone dependence in the rat.
Topics: Animals; Body Weight; Humans; Male; Mathematics; Methadone; Rats; Recurrence; Substance Withdrawal S | 1975 |
Clinical observations on methadone-maintained pregnancies.
Topics: Administration, Oral; Adult; Birth Weight; Counseling; Dose-Response Relationship, Drug; Female; Fet | 1975 |
Narcotic addiction in the newborn: differences in behavior generated by methadone and heroin.
Topics: Adaptation, Physiological; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New | 1975 |
Misuse and abuse of diazepam: an increasingly common medical problem.
Topics: Adult; Diazepam; Drug Prescriptions; Heroin Dependence; Humans; Legislation, Drug; Male; Methadone; | 1975 |
Mood, primary heroin withdrawal, and acute methadone administration.
Topics: Adolescent; Adult; Emotions; Female; Heroin Dependence; Humans; Male; Methadone; Substance Withdrawa | 1975 |
Effects of heroin and methadone on plasma cortisol and testosterone.
Topics: Adult; Heroin; Heroin Dependence; Humans; Hydrocortisone; Male; Methadone; Substance Withdrawal Synd | 1975 |
Behavior of narcotics-addicted newborns.
Topics: Adult; Attention; Female; Habituation, Psychophysiologic; Heroin; Humans; Infant, Newborn; Infant, N | 1975 |
Changes in estradiol and cortisol production rates in men under the influence of narcotics.
Topics: Adrenal Glands; Adult; Estradiol; Humans; Hydrocortisone; Male; Methadone; Opium; Substance Withdraw | 1975 |
Experimental analysis of conditioning factors in human narcotic addiction.
Topics: Adult; Blood Pressure; Body Temperature; Conditioning, Operant; Humans; Male; Methadone; Motor Skill | 1975 |
l-alpha-acetylmethadol and methadone in Buffalo: safety and efficacy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Attitude of Health Personnel; Drug Evaluation; Heroin | 1975 |
LAAM (l-alpha-acetylmethadol) study in St. Louis.
Topics: Adolescent; Adult; Age Factors; Blood Pressure; Brain; Drug Evaluation; Evoked Potentials; Heroin De | 1975 |
Methadone-induced behavioral changes: circular movements, aggression, and electrophysiological aspects.
Topics: Aggression; Animals; Brain; Drug Tolerance; Humans; Male; Methadone; Mice; Motor Activity; Substance | 1975 |
Attenuation of precipitated abstinence in methadone-dependent rats by delta 9-THC.
Topics: Animals; Behavior, Animal; Cannabis; Dronabinol; Drug Tolerance; Humans; Male; Methadone; Morphine D | 1975 |
Control of methadone dosage by patients.
Topics: Community Participation; Evaluation Studies as Topic; Humans; Informed Consent; Methadone; Substance | 1975 |
Neonatal narcotic abstinence: Effects of pharmacotherapeutic agents and maternal drug usage on nutritive sucking behavior.
Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Opium; Phenob | 1976 |
A study of factors that influence the severity of neonatal narcotic withdrawal.
Topics: Apgar Score; Female; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lighting; | 1976 |
Rifampin-induced methadone withdrawal.
Topics: Adult; Aged; Drug Interactions; Heroin Dependence; Humans; Isoniazid; Male; Methadone; Middle Aged; | 1976 |
Behavioral and social effects of heroin self-administration and withdrawal.
Topics: Adult; Energy Metabolism; Humans; Male; Methadone; Narcotic Antagonists; Sleep; Social Behavior; Sub | 1976 |
Drug addiction in pregnancy and the neonate.
Topics: Alcoholic Intoxication; Birth Weight; Diazepam; Female; Heroin Dependence; Hospitalization; Humans; | 1976 |
Pharmacologic observations on the neonatal withdrawal syndrome.
Topics: Female; Half-Life; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kinetics; | 1976 |
[Role of the psychiatrist in the methadone program. Experiences from Frankfurt am Main].
Topics: Heroin Dependence; Humans; Methadone; Patient Care Team; Physician's Role; Psychiatry; Substance Wit | 1992 |
Treatment of crack cocaine use with carbamazepine.
Topics: Adult; Carbamazepine; Crack Cocaine; Day Care, Medical; Female; Follow-Up Studies; Heroin Dependence | 1992 |
Baclofen-assisted detoxification from opiates. A pilot study.
Topics: Adult; Baclofen; Female; Humans; Male; Methadone; Neurologic Examination; Opioid-Related Disorders; | 1992 |
Mr R: a case study of withdrawal.
Topics: Alcoholism; Clonidine; Cocaine; Humans; Male; Methadone; Middle Aged; Neurologic Examination; Opioid | 1992 |
Methadone maintenance detoxification fear: a study of its components.
Topics: Acquired Immunodeficiency Syndrome; Activities of Daily Living; Adaptation, Psychological; Adult; Fe | 1992 |
Sub-chronic exposure to opiates in the rat: effects on brain levels of substance P and calcitonin gene-related peptide during dependence and withdrawal.
Topics: Animals; Brain Chemistry; Calcitonin Gene-Related Peptide; Female; Methadone; Morphine; Narcotics; O | 1992 |
The use of plasma levels to optimize methadone maintenance treatment.
Topics: Adult; Drug Monitoring; Female; Humans; Male; Methadone; Narcotics; Opioid-Related Disorders; Substa | 1992 |
Use of cocaine to prevent opiate withdrawal.
Topics: Adult; Clinical Protocols; Cocaine; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Meth | 1992 |
Beta endorphin levels during heroin, methadone, buprenorphine, and naloxone challenges: preliminary findings.
Topics: Adult; beta-Endorphin; Buprenorphine; Female; Heroin; Humans; Male; Methadone; Middle Aged; Naloxone | 1992 |
Two cases of clonidine abuse/dependence in methadone-maintained patients.
Topics: Clonidine; Dose-Response Relationship, Drug; Female; Heroin Dependence; HIV Seropositivity; Humans; | 1992 |
Methadone dosage, program policies, and heroin use among methadone patients.
Topics: Dose-Response Relationship, Drug; Heroin; Heroin Dependence; Humans; Methadone; Patient Compliance; | 1992 |
Morphine and methadone dependence in the rat: withdrawal and brain met-enkephalin levels.
Topics: Animals; Behavior, Animal; Body Weight; Brain Chemistry; Drinking; Enkephalin, Methionine; Female; M | 1992 |
Epidural sufentanil for acute pain control in a patient with extreme opioid dependency.
Topics: Adult; Analgesia, Epidural; Analgesics; Female; Fentanyl; Humans; Methadone; Pain, Postoperative; Po | 1992 |
Plasma methadone measurements and their role in methadone detoxification programs.
Topics: Adult; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Methadone; Opioid-R | 1992 |
Withdrawal from methadone maintenance. Impact of a tapering network support program.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; He | 1992 |
Withdrawal from heroin and methadone.
Topics: Heroin; Heroin Dependence; Hospitalization; Humans; Methadone; Neurologic Examination; Opioid-Relate | 1991 |
[Drug substitution and withdrawal in pregnancy. Indication, side effects, acute status, monitoring and results].
Topics: Contraindications; Counseling; Drug Overdose; Female; Heroin Dependence; Humans; Infant, Newborn; Me | 1991 |
[Jurisprudence aspects of drug substitution and withdrawal in pregnancy].
Topics: Female; Germany; Humans; Infant, Newborn; Jurisprudence; Methadone; Neonatal Abstinence Syndrome; Pr | 1991 |
Illicit use of methadone in heroin addicts in Rome.
Topics: Adolescent; Adult; Drug Utilization; Female; Heroin Dependence; Humans; Legislation, Drug; Male; Met | 1991 |
A comparison of the withdrawal responses of heroin and methadone addicts during detoxification.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heroin; Heroin Depend | 1991 |
Methadone treatment in the pediatric intensive care unit.
Topics: Child; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome; Substance-Related | 1991 |
Metyrapone-induced withdrawal symptoms: symptoms in methadone-maintained patients.
Topics: Female; Humans; Male; Methadone; Metyrapone; Opioid-Related Disorders; Substance Withdrawal Syndrome | 1990 |
Double blind assessment of buprenorphine withdrawal in opiate-addicts.
Topics: Buprenorphine; Double-Blind Method; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawa | 1990 |
Outpatient comparison of buprenorphine and methadone maintenance. I. Effects on opiate use and self-reported adverse effects and withdrawal symptomatology.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Humans; Male; Methadone; Middle Aged; Naloxone; O | 1990 |
Similar efficacy of abrupt and gradual opiate detoxification.
Topics: Adult; Anesthesia, General; Female; Humans; Length of Stay; Male; Methadone; Methohexital; Naloxone; | 1991 |
Combined naloxone/methadone preparations for opiate substitution therapy.
Topics: Administration, Oral; Adult; Drug Combinations; Humans; Infusions, Intravenous; Methadone; Naloxone; | 1991 |
Rapid transition from methadone maintenance to naltrexone.
Topics: Flumazenil; Humans; Methadone; Midazolam; Naltrexone; Substance Withdrawal Syndrome | 1990 |
Prescribing smokable drugs.
Topics: Administration, Inhalation; Amphetamine; Cocaine; Heroin; Humans; Methadone; Substance Abuse, Intrav | 1990 |
Methadone as treatment for iatrogenic narcotic dependency in pediatric intensive care unit patients.
Topics: Analgesics, Opioid; Cardiac Surgical Procedures; Female; Humans; Infant; Infant, Newborn; Male; Meth | 1990 |
Carbamazepine for high-dose diazepam withdrawal in opiate users.
Topics: Adult; Carbamazepine; Diazepam; Female; Humans; Male; Methadone; Opioid-Related Disorders; Substance | 1991 |
Technique for greatly shortening the transition from methadone to naltrexone maintenance of patients addicted to opiates.
Topics: Adult; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Methadone; Mid | 1991 |
Clonidine versus long- and short-term methadone-aided withdrawal from opiates. An uncontrolled comparison.
Topics: Adult; Clonidine; Drug Administration Schedule; Female; Heroin; Heroin Dependence; Hospitalization; | 1990 |
Static and dynamic pupillometry for determination of the course of gradual detoxification of opiate-addicted patients.
Topics: Adult; Arousal; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Image Processin | 1990 |
Metyrapone-induced withdrawal symptoms.
Topics: Adult; Female; Heroin Dependence; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Male; Meth | 1990 |
Rifampin-induced methadone withdrawal in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Humans; Male; Methadone; Mycobacterium avium-intr | 1990 |
Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate.
Topics: Adult; Diazepam; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Infant, Newborn, Diseas | 1990 |
Effects of sublingually given naloxone in opioid-dependent human volunteers.
Topics: Administration, Sublingual; Adult; Arousal; Dose-Response Relationship, Drug; Heroin Dependence; Hum | 1990 |
Self-administration of clonidine, oxazepam, and hydromorphone by patients undergoing methadone detoxification.
Topics: Adult; Clonidine; Drug Administration Schedule; Humans; Hydromorphone; Male; Methadone; Opioid-Relat | 1985 |
Unusual opioid withdrawal syndrome. A case-report.
Topics: Aged; Colonic Neoplasms; Coma; Humans; Male; Methadone; Morphine; Neoplasm Recurrence, Local; Opium; | 1987 |
Butorphanol-precipitated withdrawal in opioid-dependent human volunteers.
Topics: Butorphanol; Heart Rate; Humans; Hydromorphone; Male; Methadone; Morphinans; Naloxone; Opioid-Relate | 1987 |
Evidence of single dose opioid dependence in 12- to 14-day-old chicken embryos.
Topics: 1-Methyl-3-isobutylxanthine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamid | 1989 |
Valproic acid, unlike other anticonvulsants, has no effect on methadone metabolism: two cases.
Topics: Adult; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Phenytoin | 1989 |
Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys.
Topics: Animals; Behavior, Animal; Female; Macaca mulatta; Male; Methadone; Naloxone; Receptors, Opioid; Sub | 1989 |
Naloxone applied to conjunctiva as a test for physical opiate dependence.
Topics: Administration, Topical; Adult; Conjunctiva; Evaluation Studies as Topic; Female; Humans; Male; Meth | 1989 |
Benzodiazepine addiction in heroin addicts.
Topics: Anti-Anxiety Agents; Benzodiazepines; Heroin Dependence; Humans; Methadone; Patient Dropouts; Substa | 1989 |
Naloxone challenge as a biological predictor of treatment outcome in opiate addicts.
Topics: Arousal; Depressive Disorder; Humans; Methadone; Naloxone; Opioid-Related Disorders; Personality Tes | 1989 |
Detoxification of the chemically dependent patient.
Topics: Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Syndrome; Substance-Related Disord | 1989 |
Carbamazepine treatment of cocaine dependence in methadone maintenance patients with dual opiate-cocaine addiction.
Topics: Carbamazepine; Cocaine; Combined Modality Therapy; Dose-Response Relationship, Drug; Humans; Methado | 1989 |
Use predicts treatment outcome, not opiate dependence or withdrawal.
Topics: Adult; Cocaine; Follow-Up Studies; Humans; Male; Methadone; Naloxone; Opioid-Related Disorders; Subs | 1989 |
Severity of precipitated opiate withdrawal predicts drug dependence by DSM-III-R criteria.
Topics: Adult; Female; Humans; Male; Methadone; Naloxone; Opioid-Related Disorders; Psychiatric Status Ratin | 1989 |
Neuro-electric therapy: criticisms of the 1984 Bethlem Study.
Topics: Electric Stimulation Therapy; Humans; Methadone; Opioid-Related Disorders; Substance Withdrawal Synd | 1989 |
Endogenous opioids in cerebrospinal fluid of opioid-dependent humans.
Topics: Adult; beta-Endorphin; Heroin Dependence; Humans; Male; Methadone; Naltrexone; Radioimmunoassay; Rad | 1988 |
Personality and demographic characteristics associated with the prescribing of psychoactive medications for methadone maintenance patients.
Topics: Anti-Anxiety Agents; Antidepressive Agents; Combined Modality Therapy; Drug Therapy, Combination; He | 1986 |
Extinguishing conditioned responses during opiate dependence treatment turning laboratory findings into clinical procedures.
Topics: Behavior Therapy; Combined Modality Therapy; Conditioning, Psychological; Desensitization, Psycholog | 1986 |
Medication management in patients with chronic non-malignant pain. A review of the use of a drug withdrawal protocol.
Topics: Analgesics, Opioid; Chronic Disease; Drug Combinations; Humans; Hypnotics and Sedatives; Methadone; | 1986 |
[The drug addict in prison: Medical response and its limitations].
Topics: Acquired Immunodeficiency Syndrome; Adult; Antipsychotic Agents; Female; Humans; Male; Methadone; Pr | 1988 |
Beta endorphin levels in CSF during methadone maintenance.
Topics: Adult; Aged; Aged, 80 and over; beta-Endorphin; Endorphins; Female; Humans; Hydrocortisone; Male; Me | 1987 |
Naltrexone.
Topics: Humans; Methadone; Naltrexone; Opioid-Related Disorders; Pain; Pituitary Gland; Receptors, Opioid; S | 1985 |
The effect of methadone addiction on cyclic nucleotide levels in regions of rat brain.
Topics: Amygdala; Animals; Brain; Cerebral Ventricles; Corpus Striatum; Cyclic AMP; Cyclic GMP; Male; Methad | 1986 |
Nature and incidence of conditioned responses in a methadone population: a comparison of laboratory, clinic, and naturalistic settings.
Topics: Conditioning, Psychological; Extinction, Psychological; Heart Rate; Humans; Laboratories; Male; Meth | 1986 |
Comparison of the effects of cocaine and d-amphetamine on the pharmacological actions of methadone.
Topics: Analgesia; Animals; Body Temperature; Cocaine; Dextroamphetamine; Drug Interactions; Male; Methadone | 1987 |
Abnormalities in thyroid function associated with chronic therapy with methadone.
Topics: Adolescent; Adult; Female; Humans; Male; Methadone; Substance Withdrawal Syndrome; Thyroid Gland; Th | 1988 |
Tapering from methadone maintenance: attitudes of clients and staff.
Topics: Adult; Attitude of Health Personnel; Attitude to Health; Drug Administration Schedule; Female; Human | 1988 |
The use of serum methadone levels in patients receiving methadone maintenance.
Topics: Dose-Response Relationship, Drug; Heroin Dependence; Humans; Methadone; Substance Withdrawal Syndrom | 1988 |
Prison medicine.
Topics: Acquired Immunodeficiency Syndrome; Female; Health Services; Humans; Male; Methadone; Pharmaceutical | 1988 |
Substitution therapy of opioid withdrawal.
Topics: Dextropropoxyphene; Heroin; Humans; Methadone; Substance Withdrawal Syndrome | 1986 |
Ophthalmic naloxone elicits abstinence in opioid-dependent subjects.
Topics: Humans; Methadone; Naloxone; Ophthalmic Solutions; Opioid-Related Disorders; Pupil; Substance Withdr | 1987 |
An investigation of withdrawal symptoms shown by opiate addicts during and subsequent to a 21-day in-patient methadone detoxification procedure.
Topics: Adult; Female; Heroin; Humans; Male; Methadone; Substance Withdrawal Syndrome; Time Factors | 1987 |
[Detoxication or physical weaning].
Topics: Clonidine; Depressive Disorder; Heroin Dependence; Humans; Methadone; Substance Withdrawal Syndrome | 1987 |
Management of narcotic dependent pregnancy.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Narcotics; Opioid-Related Disorders; | 1986 |
Aspects of abstinence after morphine ingestion.
Topics: Animals; Body Weight; Diarrhea; Dose-Response Relationship, Drug; Drinking; Male; Methadone; Methods | 1987 |
Assessing pathological detoxification fear among methadone maintenance patients: the DFSS.
Topics: Adult; Fear; Female; Humans; Inactivation, Metabolic; Male; Methadone; Opioid-Related Disorders; Psy | 1987 |
Calcitonin and prolactin serum levels in heroin addicts: study on a methadone treated group.
Topics: Adult; Calcitonin; Female; Heroin Dependence; Humans; Male; Methadone; Prolactin; Substance Withdraw | 1987 |
Prevalence and diagnostic reliability of methadone maintenance detoxification fear.
Topics: Adult; Fear; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Substance Withd | 1986 |
The combined use of clonidine and naltrexone as a rapid, safe, and effective treatment of abrupt withdrawal from methadone.
Topics: Adult; Blood Pressure; Clonidine; Drug Administration Schedule; Drug Therapy, Combination; Female; H | 1986 |
[The hospitalized drug addict. Social assistance and therapeutic care].
Topics: Adolescent; Adult; Female; Heroin Dependence; Hospitalization; Humans; Italy; Male; Methadone; Occup | 1986 |
Methadone in pregnancy: clinical-toxicological aspects.
Topics: Female; Humans; Infant, Newborn; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complicat | 1986 |
Mother-infant interaction in multiproblem families: finding those at risk.
Topics: Adult; Child Development; Female; Humans; Infant; Methadone; Mother-Child Relations; Opioid-Related | 1986 |
The influence of psychological factors on the opiate withdrawal syndrome.
Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Male; Methadone; Narcotics; Neurotic Disorders | 1986 |
Fetal addiction to methadone: postnatal abstinence syndrome and development of visual evoked potentials.
Topics: Animals; Electroencephalography; Evoked Potentials, Visual; Female; Maternal-Fetal Exchange; Methado | 1986 |
Conditioned responses in a methadone population. A comparison of laboratory, clinic, and natural settings.
Topics: Conditioning, Psychological; Environment; Extinction, Psychological; Heroin Dependence; Humans; Meth | 1986 |
[Substance dependence and pregnancy. Experience in care].
Topics: Adult; Female; Fetal Growth Retardation; Heroin; Heroin Dependence; Humans; Methadone; Pregnancy; Pr | 1986 |
Occurrence of strabismus in infants born to drug-dependent women.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Male; Methadone; Pregnancy; Pregnancy Complicati | 1987 |
[Drug therapy in overdose and withdrawal syndrome in heroin addicts].
Topics: Heroin; Heroin Dependence; Humans; Methadone; Naloxone; Psychotropic Drugs; Substance Withdrawal Syn | 1985 |
Variability in simian motor and social behavior with alternating-day acetylmethadol.
Topics: Animals; Circadian Rhythm; Humans; Macaca radiata; Male; Methadone; Methadyl Acetate; Motor Activity | 1985 |
[Rifampicin induces withdrawal symptoms in methadone users].
Topics: Adult; Drug Interactions; Heroin Dependence; Humans; Male; Methadone; Rifampin; Substance Withdrawal | 1986 |
Use of guanabenz in methadone withdrawal.
Topics: Adult; Clonidine; Female; Guanabenz; Guanidines; Humans; Methadone; Opioid-Related Disorders; Substa | 1985 |
Effect of chronic methadone administration on neuroendocrine function in young adult rats.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Endocrine Glands; H | 1985 |
When the client is pregnant: information for counselors.
Topics: Adult; Attitude of Health Personnel; Breast Feeding; Family Planning Services; Female; Guilt; Heroin | 1985 |
[Withdrawal symptoms and behavioral disorders in children of mothers taking heroin/methadone during pregnancy].
Topics: Adult; Child Behavior Disorders; Child Development; Child, Preschool; Female; Follow-Up Studies; Her | 1985 |
Medical aspects of large outdoor festivals.
Topics: Adolescent; Adult; Ambulances; Camping; England; Environmental Exposure; Female; First Aid; Fracture | 1972 |
Letter: Brain adenyl cyclase in methadone treatment of morphine dependency.
Topics: Adenylyl Cyclases; Animals; Brain; Humans; Male; Methadone; Morphine Dependence; Phosphoric Diester | 1973 |
Narcotic blockade.
Topics: Drug Tolerance; Follow-Up Studies; Heroin; Humans; Hydromorphone; Injections, Intravenous; Methadone | 1966 |
Narcotic blockade--a medical technique for stopping heroin use by addicts.
Topics: Euphoria; Heroin; Humans; Hydromorphone; Methadone; Morphine; Substance Withdrawal Syndrome; Substan | 1966 |
Heroin and cocaine addiction.
Topics: Adolescent; Adult; Amphetamine; Barbiturates; Cannabis; Cocaine; Dextroamphetamine; Ethanol; Female; | 1965 |
[Discussion on methadone programs in the Federal Republic of Germany].
Topics: Ambulatory Care; Female; Germany, West; Heroin Dependence; Hospitalization; Humans; Long-Term Care; | 1973 |
Letter: Pentazocine and neonatal withdrawal symptoms.
Topics: Female; Glutethimide; Humans; Infant, Newborn; Infant, Newborn, Diseases; Long-Term Care; Maternal-F | 1974 |
Detoxification of long-term methadone patients.
Topics: Adult; Female; Goals; Heroin Dependence; Humans; Long-Term Care; Male; Methadone; Motivation; New Yo | 1973 |
New choices for methadone maintenance patients: planned, voluntary long-term detoxification.
Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Long-Term Care; Male; Methadone; Substance Wit | 1973 |
[Voluntary detoxification therapy of young drug addicts in a medical clinic (author's transl)].
Topics: Adult; Alcoholism; Barbiturates; Cannabis; Diazepam; Drug Combinations; Drug Therapy, Combination; F | 1974 |
Suppression of craving and other signs of dependence in morphine-addicted monkeys by administration of alpha-methyl-para-tyrosine.
Topics: Animals; Female; Fenclonine; Haloperidol; Haplorhini; Humans; Hypothalamus; Injections, Intravenous; | 1972 |
Estriol excretion profiles in narcotic-addicted pregnant women.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Age Fact | 1972 |
Infant of the addicted mother.
Topics: Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Disea | 1973 |
Letter: Methadone maintenance.
Topics: Humans; Legislation, Drug; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders; Un | 1974 |
Methadone and chemotherapy in drug addiction. Genocidal or lifesaving?
Topics: Alcoholics Anonymous; Erectile Dysfunction; Ethics; Evaluation Studies as Topic; Follow-Up Studies; | 1974 |
A single-dose suppression test in morphine-dependent mice.
Topics: Aminopyrine; Analgesics; Animals; Behavior, Animal; Humans; Isonipecotic Acids; Levorphanol; Male; M | 1974 |
Short-term, ambulatory detoxification of opiate addicts using methadone.
Topics: Adolescent; Adult; Ambulatory Care; Germany, West; Heroin Dependence; Humans; Male; Methadone; Milit | 1974 |
The effect of a methadone treatment program upon pregnant heroin addicts and their newborn infants.
Topics: Adult; Birth Weight; Blood Glucose; Calcium; Female; Fetus; Gestational Age; Heroin Dependence; Huma | 1974 |
The heroin addict on the rehabilitation ward.
Topics: Administration, Oral; Alcoholism; Evaluation Studies as Topic; Follow-Up Studies; Heroin Dependence; | 1974 |
Psychoanalytic considerations of the etiology of compulsive drug use.
Topics: Affective Symptoms; Amphetamine; Barbiturates; Cocaine; Compulsive Behavior; Defense Mechanisms; Emo | 1974 |
Rating the presence and severity of opiate dependence.
Topics: Humans; Injections, Intramuscular; Methadone; Naloxone; Narcotics; Substance Withdrawal Syndrome; Su | 1974 |
Drug dependence: an age-old problem compounded by old age.
Topics: Aged; Alcoholism; Dementia; Drug Prescriptions; Drug Therapy; Geriatrics; Humans; Methadone; Pharmac | 1974 |
[Letter: Prescription of methadone to young drug addicts at outpatient clinics].
Topics: Ambulatory Care; Family Practice; Humans; Methadone; Norway; Substance Withdrawal Syndrome; Substanc | 1974 |
Methadone maintenance during pregnancy: pregnancy, birth, and neonate characteristics.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Gestational Age; Heroin Dependence; Humans; In | 1974 |
The relationship between age and-or negative experiences and success on a methadone maintenance program.
Topics: Adult; Age Factors; California; Educational Status; Employment; Female; Heroin Dependence; Humans; M | 1974 |
Evolution of a treatment approach for young heroin addicts. Comparison of three treatment modalities.
Topics: Adolescent; Adult; Black or African American; Crime; Employment; Female; Follow-Up Studies; Heroin D | 1974 |
Personality characteristics of heroin addicts in a methadone treatment program: an exploratory study.
Topics: Adult; Black or African American; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; P | 1974 |
Narcotic withdrawal syndrome caused by naltrexone.
Topics: Adult; Cyclopropanes; Drug Interactions; Female; Heroin Dependence; Humans; Infusions, Parenteral; M | 1974 |
Treating the drug-dependent veteran--perspective from a Veterans Administration Hospital.
Topics: Counseling; Heroin Dependence; Hospitals, Veterans; Humans; Male; Methadone; Military Medicine; Psyc | 1974 |
Methadone on demand as a heroin detoxification preocedure.
Topics: Adolescent; Child; Drug Administration Schedule; Female; Heroin Dependence; Humans; Interprofessiona | 1974 |
Clinical uses of the Brazelton Neonatal Scale.
Topics: Child Behavior; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Metha | 1974 |
Detoxification of rehabilitated methadone patients: frequency and predictors of long-term success.
Topics: Employment; Heroin Dependence; Humans; Methadone; Motivation; Probability; Remission, Spontaneous; S | 1974 |
[Editorial: The young drug user, his parents and his doctor (author's transl)].
Topics: Attitude to Health; Cannabis; Heroin Dependence; Humans; Lysergic Acid Diethylamide; Methadone; Pare | 1974 |
Induction of physical dependence on morphine, codeine and meperidine in the rat by continuous infusion.
Topics: Animals; Behavior, Animal; Body Weight; Codeine; Dose-Response Relationship, Drug; Humans; Infusions | 1974 |
A rat model of methadone addiction.
Topics: Animals; Behavior, Animal; Body Weight; Disease Models, Animal; Drinking Behavior; Drug Tolerance; F | 1974 |
Heroin addiction: a treatable disease.
Topics: Adolescent; Adult; Analgesics; California; Community Health Services; Counseling; Heroin; Heroin Dep | 1973 |
Low dosage methadone treatment of narcotic dependents in Hong Kong.
Topics: Heroin Dependence; Hong Kong; Humans; Methadone; Substance Withdrawal Syndrome; Substance-Related Di | 1974 |
Preoperative withdrawal symptoms with methadone maintenance.
Topics: Adult; Humans; Male; Methadone; Substance Withdrawal Syndrome; Surgical Procedures, Operative | 1972 |
Modification of precipitated morphine and methadone abstinence in mice by acetylcholine antagonists.
Topics: Acetylcholine; Animals; Atropine; Drug Combinations; Humans; Mecamylamine; Methadone; Mice; Morphine | 1973 |
Pregnancies of methadone patients. Findings in New York City Methadone Maintenance Treatment Program.
Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; | 1974 |
Newborn infants of mothers on methadone maintenance.
Topics: Body Weight; Camphor; Diazepam; Female; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, D | 1974 |
Methadone-maintained patients. Effect of methadone on plasma testosterone, FSH, LH, and prolactin.
Topics: Adult; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Methadone; Prolactin; Substa | 1974 |
Studies on physical dependence inducible by hours exposure of mice to morphine.
Topics: Analgesia; Animals; Behavior, Animal; Body Weight; Drug Tolerance; Humans; Infusions, Parenteral; In | 1972 |
A scoring system for abstinence syndrome in morphine dependent mice and application to evaluate morphine type dependence liability of drugs.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Humans; Male; Meperidine; Methadone; Mi | 1973 |
Analyses of methadone and other drugs in maternal and neonatal body fluids: use in evaluation of symptoms in a neonate of mother maintained on methadone.
Topics: Adult; Amniotic Fluid; Body Fluids; Escherichia coli Infections; Female; Fetal Blood; Heroin Depende | 1974 |
Heroin addiction and the role of methadone in its treatment.
Topics: Animals; Anxiety; Compulsive Behavior; Conditioning, Classical; Conditioning, Operant; Dogs; Drug To | 1972 |
Addiction and the community. (Narcotic substitution therapy).
Topics: Health Expenditures; History, 20th Century; Humans; Methadone; Morphine Dependence; Narcotic Antagon | 1972 |
Methadone fatalities in heroin addicts.
Topics: Adolescent; Adult; Alcoholism; Female; Geography; Heroin; Heroin Dependence; Humans; Male; Methadone | 1972 |
Methadone withdrawal in the treatment of heroin addiction.
Topics: Adult; Age Factors; Alcoholism; Black or African American; Community Mental Health Services; Educati | 1972 |
Methadone maintenance: myth and reality.
Topics: Costs and Cost Analysis; Criminal Psychology; Drug Tolerance; Evaluation Studies as Topic; Heroin; H | 1972 |
Surgical patients and drug abuse syndrome.
Topics: Adolescent; Adult; Aged; Amphetamine; Barbiturates; Female; Focal Infection; Hallucinogens; Humans; | 1973 |
Alcoholism among methadone patients: a specific treatment method.
Topics: Alcohol Drinking; Alcoholism; Disulfiram; Heroin; Heroin Dependence; Hospitalization; Humans; Methad | 1973 |
Self-destructive aspects of hard core addiction.
Topics: Adolescent; Adult; Attitude; Black or African American; Death; Depression; District of Columbia; Fem | 1973 |
The drug scene: acute drug syndromes.
Topics: Alcoholic Intoxication; Amphetamine; Atropa belladonna; Atropine; Barbiturates; Cannabis; Diagnosis, | 1973 |
Legal services as a tool in treating the addict.
Topics: Crime; Forensic Psychiatry; Hospitals, Psychiatric; Humans; Jurisprudence; Methadone; Narcotics; New | 1973 |
Methadone in the Southwest: a three-year follow-up of Chicano heroin addicts.
Topics: Adolescent; Adult; Alcoholism; Child; Criminal Psychology; Ethnicity; Female; Follow-Up Studies; Her | 1973 |
Treatment of neonatal withdrawal syndrome.
Topics: Chlorpromazine; Diazepam; Heroin Dependence; Humans; Infant, Newborn; Methadone; Opium; Phenobarbita | 1973 |
Group therapy in a methadone treatment program: an evaluation of changes in interpersonal behavior.
Topics: Adult; Evaluation Studies as Topic; Female; Heroin; Heroin Dependence; Humans; Interpersonal Relatio | 1973 |
Methadone maintenance: the effect of knowledge of dosage.
Topics: Attitude; Communication; Competitive Behavior; Female; Heroin; Heroin Dependence; Humans; Male; Meth | 1973 |
Guidelines for the withdrawal of narcotic and general depressant drugs.
Topics: Barbiturates; Dose-Response Relationship, Drug; Drug Tolerance; Female; Heroin; Humans; Hypnotics an | 1973 |
Treating today's heroin user.
Topics: Drug Tolerance; Heroin; Heroin Dependence; Humans; Injections, Intravenous; Methadone; Nalorphine; O | 1973 |
Non-addictive drug antagonist program in a community setting.
Topics: Adolescent; Adult; Age Factors; Allied Health Personnel; Ambulatory Care; Community Health Services; | 1973 |
Are methadone withdrawal patients overprotected?
Topics: Adult; Heroin; Heroin Dependence; Humans; Male; Methadone; Prisoners; Substance Withdrawal Syndrome; | 1973 |
Methadone maintenance programs.
Topics: Anxiety; Crime; Heroin; Heroin Dependence; Humans; Legislation as Topic; Methadone; Motivation; Subs | 1973 |
A heroin maintenance program in the United States?
Topics: Adolescent; Adult; Age Factors; Aged; Black or African American; Black People; Cannabis; Crime; Fema | 1973 |
Pentazocine in methadone hydrochloride maintenance.
Topics: Acute Disease; Administration, Oral; Humans; Injections, Intravenous; Methadone; Pentazocine; Substa | 1973 |
Naloxone for diagnosis in methadone programs.
Topics: Humans; Informed Consent; Injections, Intramuscular; Injections, Intravenous; Methadone; Nalorphine; | 1973 |
The politics of methadone treatment.
Topics: Adolescent; Adult; Counseling; Ethnicity; Female; Heroin; Heroin Dependence; Humans; Legislation, Dr | 1973 |
Methadone maintenance, pregnancy, and progeny.
Topics: Administration, Oral; Adult; Apgar Score; Birth Weight; Female; Fetal Death; Heroin; Heroin Dependen | 1973 |
[Psychiatric emergencies during pregnancy and in the puerperium].
Topics: Amphetamine; Cannabis; Emergencies; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lyse | 1973 |
Neonatal narcotic addiction. Comparative effects of maternal intake of heroin and methadone.
Topics: Adult; Apgar Score; Birth Weight; Chlorpromazine; Female; Gestational Age; Heroin Dependence; Humans | 1973 |
Method for self-administering methadone by the heroin addict.
Topics: Administration, Oral; Adult; Conditioning, Operant; Evaluation Studies as Topic; Female; Heroin Depe | 1973 |
The sodium concentration of parotid saliva in "hard" drug addicts.
Topics: Adolescent; Adult; Diagnosis, Differential; Electrodes; Heroin Dependence; Humans; Hydrogen-Ion Conc | 1973 |
Treatment of overdose and withdrawal of abused drugs.
Topics: Amphetamine; Cathartics; Charcoal; Diuretics; Gastric Lavage; Hallucinogens; Humans; Hypnotics and S | 1973 |
Narcotic poisoning: an epidemic disease.
Topics: Diazepam; Glucose; Hospitalization; Humans; Hyperglycemia; Methadone; Myelitis, Transverse; Myoglobi | 1973 |
Adolescents and short term, low dose methadone maintenance.
Topics: Adolescent; Adult; Age Factors; Connecticut; Drug Evaluation; Female; Heroin Dependence; Humans; Mal | 1973 |
Methadone maintenance during pregnancy.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pregnancy; | 1973 |
Voluntary detoxification of patients on methadone maintenance.
Topics: Adult; Attitude; Educational Status; Employment; Female; Heroin Dependence; Humans; Male; Methadone; | 1973 |
Methadone maintenance and methadone detoxification: a comparison of retention rates and client characteristics.
Topics: Adult; Age Factors; Attitude to Health; Counseling; Educational Status; Family Characteristics; Fema | 1973 |
A chemical alternative to the narcotic antagonist thesis.
Topics: Animals; Brain Chemistry; Conditioning, Psychological; Drug Tolerance; Heroin Dependence; Humans; Me | 1973 |
Addiction Research Center: pioneers still on the frontier.
Topics: Human Experimentation; Humans; Methadone; Narcotic Antagonists; Prisons; Research; Substance Withdra | 1973 |
Effect of dopaminergic stimulation or blockade on morphine-withdrawal aggression.
Topics: Aggression; Amphetamine; Animals; Apomorphine; Dihydroxyphenylalanine; Haloperidol; Humans; Male; Me | 1973 |
Editorial: Detoxification of methadone patients, and public policy.
Topics: Chronic Disease; Follow-Up Studies; Humans; Methadone; Politics; Recurrence; Substance Withdrawal Sy | 1973 |
Rehabilitation of patients on methadone programs.
Topics: Community Health Services; Heroin Dependence; Humans; Methadone; New York City; Social Adjustment; S | 1973 |
Distributed dosage interval scheduled pick-up vs. single dosage daily methadone pick-up in narcotic rehabilitation.
Topics: Chicago; Circadian Rhythm; Cooperative Behavior; Dose-Response Relationship, Drug; Heroin Dependence | 1973 |
Detoxification of well rehabilitated methadone maintained patients.
Topics: Adult; Alcohol Drinking; Female; Heroin Dependence; Humans; Male; Methadone; New York City; Prospect | 1973 |
Alcoholism in M.M.T.P. patients: etiological factors and treatment approaches.
Topics: Alcoholism; Chronic Disease; Family Therapy; Heroin Dependence; Humans; Liver Diseases; Methadone; N | 1973 |
A hypothesis concerning the difficulty of withdrawal from maintenance on methadone.
Topics: Anxiety; California; Community Health Services; Female; Heroin Dependence; Humans; Male; Methadone; | 1973 |
Techniques of withdrawal from methadone and their outcome over six months to two years.
Topics: Adult; Female; Heroin Dependence; Humans; Male; Methadone; Methods; Substance Withdrawal Syndrome; S | 1973 |
Physical symptom complaints of patients on methadone maintenance.
Topics: Constipation; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Male; Methadone; | 1973 |
Methadone pseudowithdrawal: etiological considerations.
Topics: Anxiety; Depression; Diagnosis, Differential; Heroin Dependence; Humans; Methadone; Substance Withdr | 1973 |
Results of 120 deliveries of patients in the New York City methadone maintenance treatment program.
Topics: Adolescent; Adult; Birth Weight; Delivery, Obstetric; Demography; Ethnicity; Female; Heroin Dependen | 1973 |
Observations on the sudden death of infants born to addicted mothers.
Topics: Adult; Death, Sudden; Female; Heroin Dependence; Humans; Infant; Infant Mortality; Infant, Newborn; | 1973 |
The effect of a methadone treatment program upon pregnant addicts and their infants.
Topics: Adult; Apgar Score; Female; Hepatitis; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; | 1973 |
Clinical evaluation of pregnant methadone maintenance patients and their newborn infants.
Topics: Adolescent; Adult; Community Health Services; Evaluation Studies as Topic; Female; Heroin Dependence | 1973 |
Treatment experiences with the pregnant addict.
Topics: Adolescent; Adult; Amniotic Fluid; Female; Gestational Age; Hepatitis; Heroin Dependence; Humans; In | 1973 |
Neonatal effects of heroin addiction and methadone-treated pregnancies. Preliminary report on 70 live births.
Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Infant, Ne | 1973 |
Pregnancy in the context of narcotic addiction and methadone maintenance.
Topics: Adult; Alcoholism; Barbiturates; Chicago; Female; Heroin Dependence; Humans; Infant Mortality; Infan | 1973 |
Naloxone for diagnosis of physical dependence in applicants to methadone programs.
Topics: Heroin Dependence; Humans; Injections, Intramuscular; Injections, Intravenous; Methadone; Naloxone; | 1973 |
Physiologic implications of methadone treatment.
Topics: Adult; Alcoholism; Drug Tolerance; Electrocardiography; Female; Heroin Dependence; Hospitalization; | 1973 |
Methadone effects on pregnancy and the newborn.
Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Ma | 1973 |
Alternatives to methadone.
Topics: Adult; Ambulatory Care; California; Conflict, Psychological; Counseling; Female; Heroin Dependence; | 1973 |
Late presentation of drug withdrawal symptoms in newborns.
Topics: Birth Weight; Camphor; Diazepam; Female; Gestational Age; Heroin Dependence; Humans; Infant; Infant, | 1974 |
Chlorodyne dependence.
Topics: Adult; Capsicum; Chloroform; Drug Combinations; Ethanol; Female; Humans; London; Male; Methadone; Mi | 1974 |
Narcotic withdrawal in the newborn infant.
Topics: Diazepam; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mate | 1974 |
Born with a habit. Infants of drug-addicted mothers.
Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Barbiturates; Camphor; Chlorpromazine; Codeine; Dia | 1974 |
[Methadone therapy].
Topics: Denmark; Humans; Identity Crisis; Methadone; Opium; Substance Withdrawal Syndrome; Substance-Related | 1974 |
Perinatal tips.
Topics: Chlorpromazine; Education, Medical, Continuing; Female; Humans; Infant, Newborn; Infant, Newborn, Di | 1974 |
The use of propoxyphene napsylate in the treatment of heroin and methadone addiction.
Topics: Adolescent; Adult; Child; Dextropropoxyphene; Female; Heroin Dependence; Humans; Male; Methadone; Mi | 1974 |
Reciprocal (push-pull) effects of morphine on single units in the ventromedian and lateral hypothalamus and influences on other nuclei: with a comment on methadone effects during withdrawal from morphine.
Topics: Amygdala; Animals; Cerebral Cortex; Depression, Chemical; Drug Interactions; Electrophysiology; Huma | 1974 |
Alterations in striatal acetylcholine, acetylcholine esterase and dopamine after methadone replacement in morphine-dependent rats.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Brain Chemistry; Corpus Striatum; Dopamine; Humans; Ma | 1974 |
Letter: Methadone maintenance.
Topics: Humans; Legislation, Drug; Methadone; Morphine Dependence; Substance Withdrawal Syndrome; United Sta | 1974 |
Drug abuse treatment programs. Kicking the habit.
Topics: History, 19th Century; History, 20th Century; Hospitalization; Humans; Methadone; Morphine Dependenc | 1971 |
A bibliography of the methadone maintenance treatment of heroin addiction.
Topics: Bibliographies as Topic; Heroin; Humans; Methadone; Morphine Dependence; Substance Withdrawal Syndro | 1970 |
Methadone maintenance therapy for heroin addiction. Some surgical considerations.
Topics: Adult; Cardiac Surgical Procedures; Curettage; Dextropropoxyphene; Dilatation; Female; Fracture Fixa | 1972 |
Preliminary experiences with the treatment of opiate addiction by methadone withdrawal.
Topics: Adult; Female; Heroin; Hospitalization; Humans; Male; Methadone; Psychotherapy; Substance Withdrawal | 1972 |
Heroin addiction during pregnancy.
Topics: Adolescent; Adult; Amniocentesis; Bilirubin; Birth Weight; Female; Gestational Age; Heroin; Humans; | 1972 |
Maintenance methadone treatment of drug dependency.
Topics: Administration, Oral; Adult; Constipation; Erectile Dysfunction; Evaluation Studies as Topic; Female | 1972 |
On the treatment of stimulant abuse.
Topics: Cyclazocine; Humans; Methadone; Morphine Dependence; Psychotherapy; Reinforcement, Social; Social Ch | 1972 |
Heroin addicts in a community mental health inpatient unit.
Topics: Adult; California; Community Mental Health Services; Female; Heroin; Hospitalization; Hospitals, Tea | 1972 |
The changing face of heroin addiction in the Haight-Ashbury.
Topics: Adolescent; Adult; Amphetamine; California; Cannabis; Child; Community Health Services; Female; Hero | 1972 |
Present-day methadone prescribing in England.
Topics: Dosage Forms; Drug Prescriptions; Drug Utilization; England; Heroin; Humans; Legislation, Drug; Meth | 1972 |
"Cold turkey" in the newborn.
Topics: Adult; Australia; Diagnosis, Differential; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; | 1972 |
Methadone withdrawal in newborn infants.
Topics: Female; Gestational Age; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal- | 1972 |
Helping alcoholics abstain: an implantable substance.
Topics: Alcohol Drinking; Alcoholism; Cannabis; Delayed-Action Preparations; Disulfiram; Heroin; Humans; Met | 1972 |
Resumption of morphine self-administration by ex-addict rats: an attempt to modify tendencies to relapse.
Topics: Animals; Disease Models, Animal; Drinking Behavior; Humans; Male; Methadone; Morphine; Morphine Depe | 1972 |
Syrup methadone consumption by rats.
Topics: Animals; Behavior; Drinking Behavior; Humans; Male; Methadone; Pharmaceutical Vehicles; Rats; Soluti | 1972 |
Methadone maintenance withdrawal.
Topics: Humans; Methadone; Prisons; Substance Withdrawal Syndrome; Substance-Related Disorders | 1972 |
Treatment of morphine-type dependence by withdrawal methods.
Topics: Barbiturates; Female; Heroin; Hospitalization; Humans; Male; Meperidine; Methadone; Morphine; Pregna | 1972 |
Detoxification of sick addicts in prison.
Topics: Administration, Oral; Adolescent; Heroin; Humans; Injections, Intravenous; Male; Methadone; New York | 1972 |
Sudden deaths in infants born to methadone-maintained addicts.
Topics: Adult; Apgar Score; Birth Weight; Death, Sudden; Female; Humans; Infant; Infant Mortality; Maternal- | 1972 |
Treatment of morphine-type dependence.
Topics: Female; Gestational Age; Heroin; Humans; Male; Methadone; Morphine Dependence; Pregnancy; Substance | 1972 |
[Morphine withdrawal treatment in 197 admissions for opiates].
Topics: Adult; Humans; Methadone; Morphine Dependence; Substance Withdrawal Syndrome | 1972 |
Critique of success with methadone maintenance.
Topics: Adult; Criminal Psychology; Employment; Evaluation Studies as Topic; Follow-Up Studies; Heroin; Hosp | 1972 |
The economics of heroin treatment.
Topics: Costs and Cost Analysis; Economics, Medical; Heroin; Hospitalization; Humans; Length of Stay; Methad | 1972 |
[Methadone treatment in opiate addiction].
Topics: Adolescent; Adult; Heroin; Humans; Israel; Methadone; Opium; Substance Withdrawal Syndrome; Substanc | 1972 |
Drug addiction in pregnancy. An obstetrician's experience.
Topics: Abortion, Induced; Abortion, Spontaneous; Amenorrhea; Anesthesia, Obstetrical; Female; Humans; Infan | 1972 |
Narcotic withdrawal in the newborn.
Topics: Birth Weight; Chlorpromazine; Cocaine; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, N | 1972 |
Neonatal addiction to methadone.
Topics: Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Methado | 1971 |
Observations on heroin and methadone withdrawal in the newborn.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Heroin; Humans; Infant, Newborn; Infant, Newbo | 1971 |
An implanted reservoir of morphine solution for rapid induction of physical dependence in rats.
Topics: Animals; Body Weight; Codeine; Cyclazocine; Defecation; Female; Humans; Injections, Subcutaneous; Me | 1971 |
Development of behavioral tolerance to morphine and methadone using the schedule-controlled behavior of the pigeon.
Topics: Animals; Appetitive Behavior; Behavior, Animal; Columbidae; Drug Tolerance; Humans; Male; Methadone; | 1971 |
Methadone maintenance treatment for 25,000 heroin addicts.
Topics: Canada; Crime; Drug and Narcotic Control; Heroin; Humans; Methadone; Organization and Administration | 1971 |
Methadone and l-methadyl acetate. Use in management of narcotics addicts.
Topics: Alcohols; Humans; Male; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders; Time | 1971 |
Abrupt withdrawal of maintenance methadone.
Topics: Adult; Heroin; Humans; Male; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders | 1971 |
Neonatal biliary tract infection coincident with maternal methadone therapy.
Topics: Adult; Cholangitis; Cholecystitis; Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Disease | 1971 |
The way I see it.
Topics: Canada; Humans; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders | 1971 |
Methadone and the care of the narcotic addict: report of a Special Joint Committee of C.M.A. AND and the D.N.H.W. Food and Drug Directorate.
Topics: Canada; Drug and Narcotic Control; Heroin; Humans; Methadone; Methods; Societies, Medical; Substance | 1971 |
A study of some failures in methadone treatment.
Topics: Adult; Alcohol Drinking; Criminal Psychology; Evaluation Studies as Topic; Female; Follow-Up Studies | 1971 |
[Pharmacotherapy of morphine addiction].
Topics: Bridged-Ring Compounds; Humans; Methadone; Morphine; Morphine Dependence; Substance Withdrawal Syndr | 1971 |
Narcotics and medical practice. Medical use of morphine and morphine-like drugs and management of persons dependent on them.
Topics: American Medical Association; Female; Health Education; Heroin; Humans; Legislation, Drug; Methadone | 1971 |
Paean to Morpheus.
Topics: American Medical Association; Humans; Legislation, Drug; Methadone; Morphine Dependence; Substance W | 1971 |
GABOB withdrawal therapy in opiate addiction.
Topics: Aminobutyrates; Hong Kong; Humans; Hydroxybutyrates; Methadone; Nursing; Substance Withdrawal Syndro | 1966 |
Man Alive is alive, and well.
Topics: Humans; Maryland; Methadone; Substance Withdrawal Syndrome | 1970 |
Drugs used against addiction.
Topics: Biotransformation; Humans; Methadone; Nursing; Substance Withdrawal Syndrome; Substance-Related Diso | 1970 |
An oral method of the withdrawal treatment of heroin dependence: a five years' study of a combination of diphenoxylate (Lomotil) and chlormethiazole (Heminevrin).
Topics: Adolescent; Adult; Chlormethiazole; Cocaine; Female; Heroin; Humans; Isonipecotic Acids; Male; Metha | 1970 |
Opiate addiction.
Topics: Adult; Humans; Male; Methadone; Opium; Substance Withdrawal Syndrome; Substance-Related Disorders | 1969 |
A quantitative method for the assessment of physical dependence on narcotic analgesics in mice.
Topics: Animals; Humans; Meperidine; Methadone; Methods; Mice; Morphine Dependence; Motor Activity; Nalorphi | 1969 |
[Pentazocine dependance].
Topics: Adult; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Methadone; Middle Aged; P | 1970 |
Morphine dependent rats as a model for evaluating potential addiction liability of analgesic compounds.
Topics: Analgesics; Animals; Apomorphine; Azepines; Behavior, Animal; Codeine; Dextropropoxyphene; Diphenhyd | 1970 |
Methadone for the pentazocine-dependent patient.
Topics: Adult; Humans; Male; Methadone; Migraine Disorders; Pentazocine; Substance Withdrawal Syndrome; Subs | 1970 |
Outpatient treatment of heroin withdrawal.
Topics: Heroin; Humans; Methadone; Substance Withdrawal Syndrome; Wit and Humor as Topic | 1970 |
Hospital treatment of narcotic addiction.
Topics: Hospitalization; Humans; Methadone; Personality; Personality Disorders; Substance Withdrawal Syndrom | 1970 |
Further experience with methadone in the treatment of narcotics users.
Topics: Adult; Ambulatory Care; Community Mental Health Services; Evaluation Studies as Topic; Female; Heroi | 1970 |
Methadone maintenance programs in Minneapolis.
Topics: Adult; Ambulatory Care; Community Mental Health Services; Female; Financing, Organized; Heroin; Hosp | 1970 |
Methadone maintenance in St. Louis.
Topics: Adult; Chromatography, Thin Layer; Community Mental Health Services; Counseling; Heroin; Hospitaliza | 1970 |
Low and high methadone maintenance in the out-patient treatment of the hard core heroin adict.
Topics: Adult; Aged; Ambulatory Care; British Columbia; Community Mental Health Services; Crime; Criminal Ps | 1970 |
The New Haven Methadone Maintenance Program.
Topics: Adult; Amphetamine; Barbiturates; Cocaine; Community Health Services; Community Mental Health Servic | 1970 |
Methadone in New Orleans: patients, problems and police.
Topics: Adolescent; Adult; Antisocial Personality Disorder; Community Mental Health Services; Criminal Psych | 1970 |
Methadone in Miami.
Topics: Adolescent; Adult; Community Mental Health Services; Crime; Drug Prescriptions; Emergency Service, H | 1970 |
Blockade with methadone, cyclazocine, and naloxone.
Topics: Analgesics; Azocines; Cyclazocine; Evaluation Studies as Topic; Heroin; Hospitalization; Hospitals, | 1970 |
Low and high methadone maintenance in out-patient treatment of the heroin addict.
Topics: Adult; Aged; British Columbia; Community Health Services; Criminal Psychology; Employment; Evaluatio | 1970 |
Methadone and children.
Topics: Adolescent; Adult; Child, Preschool; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mat | 1971 |
Prevention and treatment of drug dependence.
Topics: Health Education; Humans; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders; The | 1971 |
Narcotic antagonists in the treatment of opiate dependence.
Topics: Allyl Compounds; Carbamates; Cyclazocine; Ethers, Cyclic; Humans; Male; Methadone; Morphinans; Morph | 1971 |
Heroin and the new prescribers.
Topics: Community Health Services; Heroin; Humans; Methadone; Substance Withdrawal Syndrome; Substance-Relat | 1968 |
Opiate withdrawal as measured by the Addiction Research Center Inventory (ARCI).
Topics: Alcoholism; Humans; Methadone; Opium; Psychological Tests; Psychometrics; Statistics as Topic; Subst | 1968 |
The addiction cycle to narcotics in the rat and its relation to catecholamines.
Topics: Adrenal Glands; Animals; Body Weight; Brain; Drug Tolerance; Epinephrine; Female; Growth; Humans; Le | 1968 |
XXVII. Opioid addiction problems in Canada.
Topics: Canada; Chromatography, Thin Layer; Counseling; Humans; Methadone; Milieu Therapy; Narcotic Antagoni | 1968 |
The treatment of drug addiction.
Topics: Adult; Heroin; Humans; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorders | 1965 |
Treatment of addiction in British Columbia.
Topics: Adult; Canada; Humans; Methadone; Psychotherapy; Substance Withdrawal Syndrome; Substance-Related Di | 1965 |
Is narcotic addiction a chronic disease?
Topics: Chronic Disease; Heroin; Humans; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorde | 1966 |