methadone has been researched along with Drug Overdose in 371 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This systematic review synthesizes the evidence related to methadone use and risk for overdose and cardiac arrhythmia." | 8.90 | Methadone overdose and cardiac arrhythmia potential: findings from a review of the evidence for an American Pain Society and College on Problems of Drug Dependence clinical practice guideline. ( Chou, R; Dana, T; Weimer, MB, 2014) |
| "Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain." | 8.86 | Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010) |
| "As methadone use increases, the potential for methadone-induced cardiotoxicity (MIC) may rise." | 7.96 | Acute right ventricular failure: a novel presentation of methadone-induced cardiotoxicity. ( Ahmed, MM; Al-Ani, M; Dasa, O; Radhakrishnan, NS; Taha, MB; Taha, OB, 2020) |
| "Use of the prescription opioid methadone for treatment of pain, as opposed to treatment of opioid use disorder (e." | 7.83 | Trends in Methadone Distribution for Pain Treatment, Methadone Diversion, and Overdose Deaths - United States, 2002-2014. ( Baldwin, GT; Jones, CM; Mack, KA; Manocchio, T; White, JO, 2016) |
| "Acute respiratory distress syndrome (ARDS) due to methadone (MTD) toxicity is a known but rather uncommon phenomenon." | 7.79 | Acute respiratory distress syndrome caused by methadone syrup. ( Aghabiklooei, A; Hassanian-Moghaddam, H; Shadnia, S; Zamani, N, 2013) |
| "Vital statistics data suggest that the opioid pain reliever (OPR) methadone is involved in one third of OPR-related overdose deaths, but it accounts for only a few percent of OPR prescriptions." | 7.78 | Vital signs: risk for overdose from methadone used for pain relief - United States, 1999-2010. ( , 2012) |
| "We report here the case of an infant who developed life-threatening rigid-chest syndrome after receiving an accidental overdose of methadone." | 7.76 | Methadone-induced rigid-chest syndrome after substantial overdose. ( Hack, RA; Lynch, RE, 2010) |
| "In November, 2006, the United States Food and Drug Administration issued a Health Alert for health professionals on risks of death, cardiac arrhythmias, and narcotic overdose associated with methadone." | 7.74 | Death, narcotic overdose, and serious cardiac arrhythmias: information for healthcare professionals on methadone. ( , 2007) |
| " Factors associated with recent suicide attempts were: being an RR entrant, female gender, younger age, less education, more extensive polydrug use, benzodiazepine use, recent heroin overdose, Major Depression, current suicidal ideation, Borderline Personality Disorder (BPD)and Post-Traumatic Stress Disorder." | 7.72 | Attempted suicide among entrants to three treatment modalities for heroin dependence in the Australian Treatment Outcome Study (ATOS): prevalence and risk factors. ( Darke, S; Lynskey, M; Ross, J; Teesson, M, 2004) |
| "Takotsubo cardiomyopathy is a syndrome characterized by transient apical ballooning or reversible midventricular systolic dysfunction." | 5.37 | Takotsubo cardiomyopathy due to iatrogenic methadone withdrawal. ( Bhat, T; Duvvuri, S; Jun, CH; Khattri, S; Lafferty, J; Saiful, FB; Teli, S, 2011) |
| "Methadone may cause respiratory depression." | 5.36 | Mechanisms of respiratory insufficiency induced by methadone overdose in rats. ( Baud, FJ; Chevillard, L; Declèves, X; Mager, D; Mégarbane, B; Milan, N; Ricordel, I; Risède, P, 2010) |
| "Methadone has additional pharmacologic and toxicologic properties which may complicate the assessment and treatment in overdose situations." | 5.35 | A case of serotonin syndrome associated with methadone overdose. ( Martinez, DN; Martinez, TT, 2008) |
| "Methadone was significantly less likely to have ever been prescribed than OOA." | 5.35 | A comparison of drug overdose deaths involving methadone and other opioid analgesics in West Virginia. ( Crosby, AE; Hall, AJ; Kaplan, JA; Logan, JE; McKinstry, E; Paulozzi, LJ, 2009) |
| "In the European Association for Palliative Care recommendations for cancer pain management, there was no consensus regarding the indications, titration, or monitoring of methadone." | 5.22 | Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer-Related Pain: The EQUIMETH2 Trial (Methadone for Cancer-Related Pain). ( Berleur, MP; Chvetzoff, G; Derniaux, A; Filbet, M; Lefebvre, D; Lefki, S; Poulain, P; Serra, E; Tremellat, F, 2016) |
| " The first case was due to a deadly intoxication by ecstasy and the second one to the deadly association of methadone and a possible neuroleptic malignant syndrome." | 4.98 | Postmortem Hyperthermia: Two Case Reports and a Review of the Literature. ( Franchi, A; Gambier, N; Gauchotte, G; Martrille, L; Raul, JS, 2018) |
| "This systematic review synthesizes the evidence related to methadone use and risk for overdose and cardiac arrhythmia." | 4.90 | Methadone overdose and cardiac arrhythmia potential: findings from a review of the evidence for an American Pain Society and College on Problems of Drug Dependence clinical practice guideline. ( Chou, R; Dana, T; Weimer, MB, 2014) |
| "Methadone was responsible for the most deaths at 10 (50%), and hydrocodone was second at four deaths (20%) The most common risk factors found in the medical records of decedents included prescriber error in initiating, converting or titrating doses, patient nonadherence to medical instruction, presence of comorbid mental disorders, toxicological presence of benzodiazepines, middle age, and unrelieved pain." | 4.87 | A review of forensic implications of opioid prescribing with examples from malpractice cases involving opioid-related overdose. ( Rich, BA; Webster, LR, 2011) |
| "Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain." | 4.86 | Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010) |
| " Among those on methadone or buprenorphine (N = 108), multivariable logistic regression models examined the association between socio-demographics, MOUD type; and past-30-day use of heroin/fentanyl; crack; benzodiazepines; and pain medications." | 4.31 | Drug use patterns and factors related to the use and discontinuation of medications for opioid use disorder in the age of fentanyl: findings from a mixed-methods study of people who use drugs. ( Case, P; Green, TC; Hughto, JMW; Moyo, P; Palacios, WR; Rapisarda, SS; Silcox, J; Stopka, TJ; Tapper, A, 2023) |
| "To assess whether the methadone take-home policy change was associated with drug overdose deaths among different racial, ethnic, and sex groups." | 4.31 | Racial, Ethnic, and Sex Differences in Methadone-Involved Overdose Deaths Before and After the US Federal Policy Change Expanding Take-home Methadone Doses. ( Bao, Y; Harris, RA; Long, JA; Mandell, DS, 2023) |
| "As methadone use increases, the potential for methadone-induced cardiotoxicity (MIC) may rise." | 3.96 | Acute right ventricular failure: a novel presentation of methadone-induced cardiotoxicity. ( Ahmed, MM; Al-Ani, M; Dasa, O; Radhakrishnan, NS; Taha, MB; Taha, OB, 2020) |
| " Shin hyperpigmentation was found to be significantly more frequent in patients with lead poisoning." | 3.88 | Observational study of dermatological manifestations in patients admitted to a tertiary poison center in Iran ( Ahmadi, S; Dadkhahfar, S; Gheisari, M; Nasiri, S; Talaie, H, 2018) |
| " Methadone is an opioid prescribed for pain management and is also provided through opioid treatment programs to treat opioid use disorders." | 3.85 | Methadone Prescribing and Overdose and the Association with Medicaid Preferred Drug List Policies - United States, 2007-2014. ( Alexander, C; Bohm, M; Faul, M, 2017) |
| " The objective of this study was to identify risk factors and determine awareness of risk for opioid overdose in veterans treated with opioids for chronic pain, using veterans treated with methadone or buprenorphine for opioid use disorder as a high-risk comparator group." | 3.83 | Risk factors for opioid overdose and awareness of overdose risk among veterans prescribed chronic opioids for addiction or pain. ( Miller, SC; Stein, MD; Tiffany, E; Wilder, CM; Winhusen, T; Winstanley, EL, 2016) |
| "Use of the prescription opioid methadone for treatment of pain, as opposed to treatment of opioid use disorder (e." | 3.83 | Trends in Methadone Distribution for Pain Treatment, Methadone Diversion, and Overdose Deaths - United States, 2002-2014. ( Baldwin, GT; Jones, CM; Mack, KA; Manocchio, T; White, JO, 2016) |
| "Corrected QT interval (QTc) prolongation is long considered as a predisposing factor for the occurrence of torsade de pointes (TdP) and sudden cardiac arrest in methadone maintenance treatment." | 3.80 | The correlation between prolonged corrected QT interval with the frequency of respiratory arrest, endotracheal intubation, and mortality in acute methadone overdose. ( Azizi, Z; Farsi, D; Hassanian-Moghaddam, H; Jamshidnejad, N; Mirafzal, A; Zehtabchi, S, 2014) |
| "Acute respiratory distress syndrome (ARDS) due to methadone (MTD) toxicity is a known but rather uncommon phenomenon." | 3.79 | Acute respiratory distress syndrome caused by methadone syrup. ( Aghabiklooei, A; Hassanian-Moghaddam, H; Shadnia, S; Zamani, N, 2013) |
| "The purpose of the present study is to determine the role of lidocaine, caffeine and dextromethorphan, used as adulterant substances, in five cases of drug overdose which have come to our attention." | 3.79 | The pathogenetic role of adulterants in 5 cases of drug addicts with a fatal outcome. ( Barbera, N; Busardò, FP; Indorato, F; Romano, G, 2013) |
| "Vital statistics data suggest that the opioid pain reliever (OPR) methadone is involved in one third of OPR-related overdose deaths, but it accounts for only a few percent of OPR prescriptions." | 3.78 | Vital signs: risk for overdose from methadone used for pain relief - United States, 1999-2010. ( , 2012) |
| "We report here the case of an infant who developed life-threatening rigid-chest syndrome after receiving an accidental overdose of methadone." | 3.76 | Methadone-induced rigid-chest syndrome after substantial overdose. ( Hack, RA; Lynch, RE, 2010) |
| "The study aimed to determine patterns of major depression (MD) across 36 months, and the relationship to outcomes for the treatment of heroin dependence." | 3.75 | Patterns of major depression and drug-related problems amongst heroin users across 36 months. ( Darke, S; Havard, A; Mills, K; Ross, J; Teesson, M; Williamson, A, 2009) |
| "In November, 2006, the United States Food and Drug Administration issued a Health Alert for health professionals on risks of death, cardiac arrhythmias, and narcotic overdose associated with methadone." | 3.74 | Death, narcotic overdose, and serious cardiac arrhythmias: information for healthcare professionals on methadone. ( , 2007) |
| "Concerns that treatment for heroin dependence using naltrexone may increase suicide rates during treatment and fatal overdoses posttreatment have been expressed." | 3.74 | Mortality in heroin users 3 years after naltrexone implant or methadone maintenance treatment. ( Hulse, GK; Ngo, HT; Tait, RJ, 2008) |
| "Age-adjusted death rates for methadone-related death, logistic regression models for likelihood of methadone-related death among all unintentional drug overdose deaths and bivariate comparisons within methadone-related death." | 3.73 | Unintentional methadone-related overdose death in New Mexico (USA) and implications for surveillance, 1998-2002. ( Landen, MG; Lathrop, SL; Shah, N, 2005) |
| " Factors associated with recent suicide attempts were: being an RR entrant, female gender, younger age, less education, more extensive polydrug use, benzodiazepine use, recent heroin overdose, Major Depression, current suicidal ideation, Borderline Personality Disorder (BPD)and Post-Traumatic Stress Disorder." | 3.72 | Attempted suicide among entrants to three treatment modalities for heroin dependence in the Australian Treatment Outcome Study (ATOS): prevalence and risk factors. ( Darke, S; Lynskey, M; Ross, J; Teesson, M, 2004) |
| "This paper provides a mainly qualitative investigation of the role of methadone and methadone treatment in non-fatal illicit drug overdose." | 3.70 | Methadone, methadone treatment and non-fatal overdose. ( Neale, J, 2000) |
| " In the majority of cases (60%) death was deemed to be accidental and most were due to accidental drug overdoses, with methadone being the drug most commonly detected on toxicological analysis." | 3.69 | Deaths among drug abusers in south-east Scotland (1989-1994). ( Bentley, AJ; Busuttil, A, 1996) |
| " The autopsy and toxicological analyses revealed that death was caused by an overdose of methadone and that the necroses in the groins were fistulas facilitating administration of the drugs directly into larger veins." | 3.68 | Fatal poisoning with intravenously injected methadone and no fresh injection marks found. ( Gregersen, M; Jensen, S, 1991) |
| "Opioid use disorder is common among detainees in US jails, yet methadone treatment is rarely initiated." | 2.94 | Methadone treatment of arrestees: A randomized clinical trial. ( Jaffe, JH; Kelly, SM; Mitchell, SG; O'Grady, KE; Schwartz, RP; Sharma, A, 2020) |
| "Buprenorphine appears to be a safe and effective substitute for naloxone in overdosed opioid-dependent patients." | 2.94 | Buprenorphine to reverse respiratory depression from methadone overdose in opioid-dependent patients: a prospective randomized trial. ( Buckley, NA; Hassanian-Moghaddam, H; Zamani, N, 2020) |
| "Although the treatment of opioid use disorder (OUD) is a key element in the response to the opioid overdose epidemic, currently available pharmacotherapies (e." | 2.94 | Slow release oral morphine versus methadone for opioid use disorder in the fentanyl era (pRESTO): Protocol for a non-inferiority randomized clinical trial. ( Bach, P; Brar, R; Dong, H; Fairbairn, N; Murphy, SM; Socias, ME; Wood, E, 2020) |
| "Methadone maintenance treatment (MMT) may prevent overdose and death among homeless people with opioid dependence, but suboptimal medication adherence is a common limitation." | 2.87 | The effect of Housing First on adherence to methadone maintenance treatment. ( Moniruzzaman, A; Parpouchi, M; Rezansoff, SN; Russolillo, A; Somers, JM, 2018) |
| "Delayed leukoencephalopathy should be suspected in patients who deteriorate after methadone overdose." | 2.79 | Clinical and radiological findings in methadone-induced delayed leukoencephalopathy. ( Bileviciute-Ljungar, I; Carlsson, J; Häglund, V; von Heijne, A, 2014) |
| " We systematically searched for studies of acute toxicity of quetiapine or other antipsychotics combined with morphine or methadone." | 2.72 | Quetiapine and other antipsychotics combined with opioids in legal autopsy cases: A random finding or cause of fatal outcome? ( Andersen, CU; Andersen, FD; Simonsen, U, 2021) |
| " There was credible evidence of a strong relationship between opioids and SDB with noted risk factors including use of methadone, high opioid dosing (>200 mg MED) and combining opioids with benzodiazepines." | 2.52 | Opioid Therapy and Sleep Disorders: Risks and Mitigation Strategies. ( Cheatle, MD; Webster, LR, 2015) |
| "Methadone treatment has been 'programmatic', with a one-size-fits-all approach that in part reflects the perceived need to impose discipline on deviant individuals." | 2.50 | Pharmacological maintenance treatments of opiate addiction. ( Bell, J, 2014) |
| "Methadone is a long-acting synthetic opioid with high affinity for various opioid receptors, especially for m-opioid receptors." | 2.45 | [Methadone treatment and its dangers]. ( Jodziūniene, L; Lazauskas, R; Reingardiene, D, 2009) |
| "Methadone is an opioid with complex properties, and a patient that is taking methadone can represent a unique challenge to the anesthesiologist." | 2.43 | Review article: perioperative pain management of patients on methadone therapy. ( Gourlay, D; Peng, PW; Tumber, PS, 2005) |
| "Methadone was found to be the most toxic of the opioids; doses as low as a single tablet can lead to death." | 2.43 | Are one or two dangerous? Opioid exposure in toddlers. ( Sachdeva, DK; Stadnyk, JM, 2005) |
| "Methadone is a synthetic opioid, used both as an analgesic in severe pain relief and now mainly in the treatment of opiate dependence." | 2.42 | The effects of methadone and its role in fatalities. ( Corkery, JM; Ghodse, AH; Oyefeso, A; Schifano, F, 2004) |
| "Mortality from opioid use disorder (OUD) can be reduced for patients who receive opioid agonist treatment (OAT)." | 1.91 | A comparison of mortality rates for buprenorphine versus methadone treatments for opioid use disorder. ( Gottlieb, DJ; Hoyt, JE; Peltzman, T; Riblet, NB; Shiner, B; Teja, N; Watts, BV, 2023) |
| " The restrictions on methadone availability including take-home dosing were loosened during the COVID-19 pandemic although there have been concerns about the high street value of diverted methadone." | 1.91 | Examination of methadone involved overdoses during the COVID-19 pandemic. ( Kaufman, DE; Kennalley, AL; McCall, KL; Piper, BJ, 2023) |
| "Buprenorphine was associated with greater protection against overdose death than methadone for clients with circulatory (MSM aIRR = 0." | 1.91 | Does opioid agonist treatment reduce overdose mortality risk in people who are older or have physical comorbidities? Cohort study using linked administrative health data in New South Wales, Australia, 2002-17. ( Ali, R; Degenhardt, L; Hickman, M; Jones, NR; Larney, S; Nielsen, S, 2023) |
| "Among patients with opioid use disorder seeking medication treatment, the risk of overdose events over the next 24 weeks is elevated among those who fail to initiate or discontinue medication and those who report benzodiazepine use at baseline." | 1.91 | Risk of Experiencing an Overdose Event for Patients Undergoing Treatment With Medication for Opioid Use Disorder. ( Balise, RR; Brandt, L; Castillo, F; Feaster, DJ; Hu, MC; Liu, Y; Luo, SX; Nunes, EV; Odom, GJ, 2023) |
| " Our objective was to assess the safety of rapid inpatient methadone initiation with regard to mortality, overdose, and serious adverse outcomes both in-hospital and postdischarge." | 1.91 | Safety of rapid inpatient methadone initiation protocol: A retrospective cohort study. ( Berger, O; Bou Harfouch, LT; Buresh, ME; Patel, SM; Racha, S, 2023) |
| "Naloxone was prescribed in 16." | 1.91 | Naloxone prescriptions among patients with a substance use disorder and a positive fentanyl urine drug screen presenting to the emergency department. ( Ali, SA; Bedder, M; Harris, R; Shell, J, 2023) |
| "Methadone, an OUD treatment, has been shown to be effective in reducing the risk of overdose and improving overall health and quality of life." | 1.91 | Dynamic changes in methadone utilisation for opioid use disorder treatment: a retrospective observational study during the COVID-19 pandemic. ( Fanelli, JL; Furst, JA; Jarvis, MA; Kennalley, AL; McCall, KL; Mynarski, NJ; Nichols, SD; Piper, BJ, 2023) |
| "Buprenorphine was initiated by 58% and 42% started methadone." | 1.72 | Factors associated with retention on medications for opioid use disorder among a cohort of adults seeking treatment in the community. ( Biondi, BE; Schlossberg, EF; Shaw, A; Springer, SA; Vander Wyk, B, 2022) |
| "The primary outcome was opioid overdose (fatal and non-fatal) while on treatment, with secondary outcomes including opioid overdose (first 30 days of treatment), treatment discontinuation, health-care interactions related to treatment of opioid use disorder, receiving a weekly supply of take-home doses and opioid overdose within 30 days of treatment discontinuation." | 1.72 | Duration of use and outcomes among people with opioid use disorder initiating methadone and buprenorphine in Ontario: a population-based propensity-score matched cohort study. ( Antoniou, T; Bozinoff, N; Campbell, T; Gomes, T; Mamdani, M; McCormack, D; Munro, C; Paterson, JM; Sproule, B; Tadrous, M, 2022) |
| "If methadone distribution was to expand to FQHCs, more counties and a larger area of Georgia would have greater access to methadone treatment." | 1.72 | Access to methadone clinics and opioid overdose deaths in Georgia: A geospatial analysis. ( Anwar, T; Duever, M; Jayawardhana, J, 2022) |
| "Methadone treatment (MT) for opioid use disorder is only available in opioid treatment programs (OTPs) in the United States, with retention predictive of positive health outcomes." | 1.72 | Comprehensive analysis of discharge reasons from methadone outpatient treatment programs. ( Andraka-Christou, B; Nguyen, TD; Totaram, R, 2022) |
| "The proportion of opioid overdose deaths increased by 36% post-COVID emergence (95% CI: 14%, 59%)." | 1.72 | Impact of COVID-19 on the characteristics of opioid overdose deaths in Arkansas. ( Fairman, BJ; Rezaeiahari, M, 2022) |
| " Rigorous supervision of daily dosing at opioid maintenance clinics as well as efforts to control the black-market offering methadone are needed to prevent further methadone-related acute poisonings and deaths." | 1.72 | Trends of acute drug and chemical toxicities in adults and adolescents in Tehran, Iran between 2012 and 2018: a retrospective chart review. ( Amirabadizadeh, A; Hadeiy, SK; Hassanian-Moghaddam, H; Khoshkar, A; Kolahi, AA; Parhizgar, P; Rezaei, O; Zamani, N, 2022) |
| "On March 16, 2020, Ukraine's Ministry of Health issued nonspecific interim guidance to continue enrolling patients in opioid agonist therapies (OAT) and transition existing patients to take-home dosing to reduce community COVID-19 transmission." | 1.62 | Rapid transitional response to the COVID-19 pandemic by opioid agonist treatment programs in Ukraine. ( Altice, FL; Dvoryak, S; Farnum, SO; Filippovych, M; Fomenko, T; Galvez de Leon, SJ; Islam, ZM; Madden, LM; Meteliuk, A; Pykalo, I, 2021) |
| "Persons with opioid use disorder (OUD) and co-occurring alcohol use disorder (AUD) are understudied and undertreated." | 1.62 | Association of Opioid Use Disorder Treatment With Alcohol-Related Acute Events. ( Bhat, NR; Bierut, LJ; Borodovsky, JT; Grucza, RA; Mintz, CM; Presnall, N; Xu, KY, 2021) |
| " We also analyzed state-level data on confirmed accidental opioid-involved deaths to assess if relaxation of take-home dosing restrictions and in-person attendance requirements correlated with increased methadone-involved fatal overdose rates." | 1.62 | Changes in methadone program practices and fatal methadone overdose rates in Connecticut during COVID-19. ( Brothers, S; Heimer, R; Viera, A, 2021) |
| "Type of medication for opioid use disorder received appeared to be age associated." | 1.56 | Characteristics and Receipt of Medication Treatment Among Young Adults Who Experience a Nonfatal Opioid-Related Overdose. ( Bagley, SM; Bernson, D; Hadland, SE; Land, T; Larochelle, MR; Patel, A; Samet, JH; Silverstein, M; Walley, AY; Wang, N; Xuan, Z, 2020) |
| "A single poisoning was found in 62." | 1.56 | Non-Opioid Substances Acute Poisonings with Suicidal Intent in Patients with Opioid Use Disorder. ( Babulovska, A; Simonovska, NK; Stefanovska, VV, 2020) |
| "Fentanyl has become widespread in the illicit opioid supply, and is a major driver of overdose mortality." | 1.51 | Fentanyl exposure and preferences among individuals starting treatment for opioid use disorder. ( Gryczynski, J; Hill, P; Mitchell, SG; Nichols, H; Schwartz, RP; Wireman, K, 2019) |
| "Drug overdose is the major cause of morbidity and mortality among persons who inject drugs (PWID)." | 1.51 | Overdose mortality rates in Croatia and factors associated with self-reported drug overdose among persons who inject drugs in three Croatian cities. ( Begovac, J; Bozicevic, I; Handanagic, S; Rutherford, GW; Sekerija, M, 2019) |
| "Methadone has a long history of pain relief and successful substitute for maintenance treatment in heroin and narcotic addiction." | 1.48 | Forensic Toxicology Perspectives of Methadone-associated Deaths in Tehran, Iran, a 7-year Overview. ( Akhgari, M; Amini-Shirazi, N; Iravani, FS, 2018) |
| "Methadone was found in 56 of those cases and was declared as the cause of death in 39 cases (70%)." | 1.48 | Methadone Maintenance Treatment: A 15-year Retrospective Study in Split-Dalmatia County, Croatia. ( Definis-Gojanovic, M; Kljucevic, Z; Sliskovic, L; Susnjar, H; Sutlovic, D; Viskovic, I, 2018) |
| "Drug overdoses are the leading cause of accidental death in the United States." | 1.48 | Medical, psychosocial, and treatment predictors of opioid overdose among high risk opioid users. ( Cropsey, KL; Dantzler, J; Galbraith, JW; Hodgin, K; Schiavon, S; Sellers, A; Word, M, 2018) |
| "Buprenorphine was associated with decreased all-cause mortality (AHR, 0." | 1.48 | Medication for Opioid Use Disorder After Nonfatal Opioid Overdose and Association With Mortality: A Cohort Study. ( Bagley, SM; Bernson, D; Land, T; Larochelle, MR; Liebschutz, JM; Stopka, TJ; Walley, AY; Wang, N; Xuan, Z, 2018) |
| "For methadone, there were significant reductions in the rate of suicidal behaviors (hazard ratio=0." | 1.48 | Medications for Alcohol and Opioid Use Disorders and Risk of Suicidal Behavior, Accidental Overdoses, and Crime. ( Binswanger, IA; Fazel, S; Hellner, C; Larsson, H; Molero, Y; Zetterqvist, J, 2018) |
| " There is a need to better understand risk for adverse outcomes during and after OAT, and for innovative approaches to identifying people at greatest risk of adverse outcomes." | 1.48 | Using routinely collected data to understand and predict adverse outcomes in opioid agonist treatment: Protocol for the Opioid Agonist Treatment Safety (OATS) Study. ( Ali, R; Degenhardt, L; Dobbins, T; Fiellin, DA; Hickman, M; Jones, NR; Larney, S; Mattick, RP; Nielsen, S, 2018) |
| "Relapse was common (57%)." | 1.48 | Methadone maintenance treatment among patients exposed to illicit fentanyl in Rhode Island: Safety, dose, retention, and relapse at 6 months. ( Carroll, JJ; Green, TC; Rich, JD; Stone, AC, 2018) |
| " Changes in PO deaths in combination with other psychoactive substances may provide a partial explanation." | 1.46 | Increases from 2002 to 2015 in prescription opioid overdose deaths in combination with other substances. ( Griesler, P; Hu, MC; Kandel, DB; Wall, M, 2017) |
| "Drug overdose is the leading cause of accidental death in Canada and the US, and the growing toll of opioid-related morbidity and mortality requires a diversity of novel therapeutic and harm reduction-based interventions." | 1.46 | Rationale for cannabis-based interventions in the opioid overdose crisis. ( Lucas, P, 2017) |
| "Adults treated for opioid dependence during April 2005 to March 2009: 151,983 individuals; 69% male; median age 32." | 1.43 | Impact of treatment for opioid dependence on fatal drug-related poisoning: a national cohort study in England. ( Bird, SM; Dunn, G; Hickman, M; Jones, A; Marsden, J; Millar, T; Pierce, M, 2016) |
| "To test if polysubstance use profiles and drug-related outcomes differ between those receiving and not receiving opioid substitution therapies (OST) among people who inject drugs (PWID)." | 1.43 | Differences in polysubstance use patterns and drug-related outcomes between people who inject drugs receiving and not receiving opioid substitution therapies. ( Alati, R; Betts, KS; Burns, L; Chan, G; Dietze, P; McIlwraith, F; Whittaker, E, 2016) |
| " Dosage increase(26." | 1.43 | [Overdose of heroin and influencing factors in intravenous drug users in parts of Yunnan]. ( Cao, XB; Luo, W; Wu, ZY; Zhang, B; Zhou, Y, 2016) |
| "Methadone was detected in 130 overdose deaths (71." | 1.43 | Methadone-Related Overdose Deaths in a Liberal Opioid Maintenance Treatment Programme. ( Andersen, LV; Christoffersen, DJ; Clausen, T; Linnet, K; Skurtveit, S; Tjagvad, C, 2016) |
| "A sample of 1179 PWID with opioid use disorder not currently on OAT from five regions in Ukraine was assessed using multivariable logistic regression for independent factors related to willingness to initiate OAT, stratified by their past OAT experience." | 1.43 | Determinants of willingness to enroll in opioid agonist treatment among opioid dependent people who inject drugs in Ukraine. ( Altice, FL; Bojko, MJ; Dvoriak, S; Filippovych, S; Makarenko, I; Marcus, R; Mazhnaya, A; Polonsky, M; Springer, S, 2016) |
| "Drug overdose is now the leading cause of unintentional death nationwide, driven by increased prescription opioid overdoses." | 1.42 | Opioid Overdose Deaths in the City and County of San Francisco: Prevalence, Distribution, and Disparities. ( Burke, C; Coffin, PO; Lemos, NP; Santos, GM; Visconti, AJ, 2015) |
| "10 patients (9/10 with chronic airflow obstruction) undergoing supervised injectable opioid treatment for heroin addiction received their usual prescribed dose of injectable opioid (diamorphine or methadone) (IOT), and their usual prescribed dose of oral opioid (methadone or sustained release oral morphine) after 30 minutes." | 1.42 | Understanding Heroin Overdose: A Study of the Acute Respiratory Depressant Effects of Injected Pharmaceutical Heroin. ( Bell, J; Jolley, CJ; Moxham, J; Rafferty, GF; Strang, J, 2015) |
| "Methadone is a long-acting opioid that carries a higher risk profile than other opioids." | 1.42 | Methadone related deaths compared to all prescription related deaths. ( Castillo, EM; Egnatios, J; Lee, A; Lee, O; Lev, R; Lucas, J; Petro, S; Vilke, GM, 2015) |
| "Methadone plays an increasing role in drug-related deaths in Hamburg." | 1.40 | Intravenous methadone application as a serious risk factor for an overdose death: methadone-related fatalities in Hamburg from 2007 to 2012. ( Andresen-Streichert, H; Elakkary, S; Heinemann, A; Iwersen-Bergmann, S; Jungen, H; Müller, A; Püschel, K, 2014) |
| "Methadone treatment was introduced in Taiwan in 2006 as a harm-reduction program for injection drug users (IDUs), among whom HIV was endemic." | 1.40 | Prevalence and factors associated with HIV infection among injection drug users at methadone clinics in Taipei, Taiwan. ( Chou, P; Deng, CY; Jiang, XR; Li, LH; Lin, T; Yen, MY; Yen, YF, 2014) |
| "Poisoning is the leading cause of injury death in the United States (1)." | 1.40 | Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011. ( Chen, LH; Hedegaard, H; Warner, M, 2014) |
| " We outline the various pharmacokinetic mechanisms involved when combining TVR with methadone or morphine and recommend that current data are not sufficiently robust to minimize the potentially significant interaction with opioids, especially methadone." | 1.39 | Potential P-glycoprotein pharmacokinetic interaction of telaprevir with morphine or methadone. ( Ashley, CC; Carlyn, C; Fontenelle, DV; Fudin, HR; Fudin, J; Hinden, DA, 2013) |
| "Methadone overdose can cause DAL with profound disturbances of neural metabolism and the BBB." | 1.39 | Imaging of subacute blood-brain barrier disruption after methadone overdose. ( Gasparovic, C; Huisa, BN; Prestopnik, JL; Rosenberg, GA; Taheri, S, 2013) |
| "Methadone poisonings were associated with accidental overdoses with the drug concentration in blood remaining within a therapeutic range." | 1.38 | Comparison of fatal poisonings by prescription opioids. ( Häkkinen, M; Launiainen, T; Ojanperä, I; Vuori, E, 2012) |
| "The methadone was obtained by illegal diversion (sale, gift, or theft) in 67% of cases." | 1.37 | The methadone epidemic: methadone-related deaths on the rise in Vermont. ( Madden, ME; Shapiro, SL, 2011) |
| "Methadone has been used for many years in the clinical setting and has many well-described side effects." | 1.37 | Methadone, another cause of opioid-associated hearing loss: a case report. ( Babu, KM; Hack, JB; Shaw, KA, 2011) |
| " The objective of this study is to elucidate the reason for the low methadone dosage prescribed in MMT clinics in China." | 1.37 | A qualitative study exploring the reason for low dosage of methadone prescribed in the MMT clinics in China. ( Detels, R; Lin, C, 2011) |
| "Takotsubo cardiomyopathy is a syndrome characterized by transient apical ballooning or reversible midventricular systolic dysfunction." | 1.37 | Takotsubo cardiomyopathy due to iatrogenic methadone withdrawal. ( Bhat, T; Duvvuri, S; Jun, CH; Khattri, S; Lafferty, J; Saiful, FB; Teli, S, 2011) |
| "Methadone may cause respiratory depression." | 1.36 | Mechanisms of respiratory insufficiency induced by methadone overdose in rats. ( Baud, FJ; Chevillard, L; Declèves, X; Mager, D; Mégarbane, B; Milan, N; Ricordel, I; Risède, P, 2010) |
| "Buprenorphine is a partial opioid agonist with a "ceiling effect" for respiratory depression." | 1.36 | Prospective comparative assessment of buprenorphine overdose with heroin and methadone: clinical characteristics and response to antidotal treatment. ( Baud, FJ; Buisine, A; Chevillard, L; Jacobs, F; Mégarbane, B; Résière, D; Vicaut, E, 2010) |
| "To evaluate the impact of introduction of supervision of methadone dosing on deaths related to overdose of methadone in Scotland and England between 1993 and 2008 while controlling for increased prescribing of methadone." | 1.36 | Impact of supervision of methadone consumption on deaths related to methadone overdose (1993-2008): analyses using OD4 index in England and Scotland. ( Bird, SM; Hall, W; Hickman, M; Strang, J, 2010) |
| "Methadone was the culprit in 3 boys and 1 girl, resulting in respiratory failure, depressed conscious state and pinpoint pupils." | 1.35 | Poisoning necessitating pediatric ICU admissions: size of pupils does matter. ( Cheung, KL; Ho, JK; Hon, KL; Hung, EC; Ng, PC, 2008) |
| "This is a case report of a CPP treated by a pain physician." | 1.35 | Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report. ( Cole, B; Fishbain, DA; Gao, J; Lewis, JE; Rosomoff, RS, 2009) |
| "Methadone has additional pharmacologic and toxicologic properties which may complicate the assessment and treatment in overdose situations." | 1.35 | A case of serotonin syndrome associated with methadone overdose. ( Martinez, DN; Martinez, TT, 2008) |
| "Methadone was significantly less likely to have ever been prescribed than OOA." | 1.35 | A comparison of drug overdose deaths involving methadone and other opioid analgesics in West Virginia. ( Crosby, AE; Hall, AJ; Kaplan, JA; Logan, JE; McKinstry, E; Paulozzi, LJ, 2009) |
| "A total of 22 sudden cardiac death cases with therapeutic levels of methadone (mean 0." | 1.35 | A community-based evaluation of sudden death associated with therapeutic levels of methadone. ( Chugh, SS; Gunson, K; Jui, J; Reinier, K; Socoteanu, C; Waltz, J, 2008) |
| "Treatment with methadone, for both pain and opioid dependence, should be preceded by an abuse liability evaluation." | 1.35 | Methadone- and heroin-related deaths in Florida. ( Gold, MS; Goldberger, BA; Graham, NA; Merlo, LJ, 2008) |
| "Methadone ingestion may cause delayed coma and require naloxone infusion." | 1.34 | Onset of symptoms after methadone overdose. ( D'Incognito, C; LoVecchio, F; Pizon, A; Riley, B; Sami, A, 2007) |
| "In a cohort of 501 drug abusers admitted to treatment in the period 1981-1991, mortality has been calculated as incidence rates." | 1.34 | Fatal overdoses and deaths by other causes in a cohort of Norwegian drug abusers--a competing risk approach. ( Amundsen, EJ; Kielland, KB; Ødegård, E, 2007) |
| "Two cases are described where diabetic ketoacidosis was found in conjunction with significant levels of prescription drugs." | 1.33 | Diabetic ketoacidosis--a possible complicating factor in deaths associated with drug overdose: two case reports. ( Byard, RW; Felgate, HE; Kostakis, C; Riches, KJ, 2006) |
| "Methadone injectors were also more likely to engage in risky behaviours associated with heroin overdose, including using heroin when no other people were present, not trial-tasting new batches of heroin and polydrug use." | 1.32 | Prevalence and correlates of intravenous methadone syrup administration in Adelaide, Australia. ( Ali, R; Darke, S; Humeniuk, R; McGregor, C, 2003) |
| "The study estimated serious adverse event (SAE) rates among entrants to pharmacotherapies for opioid dependence, during treatment and after leaving treatment." | 1.32 | Serious adverse events in the Australian National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD). ( Digiusto, E; Mattick, RP; O'Brien, S; Ritter, A; Shakeshaft, A, 2004) |
| "Methadone treatment has been shown to be an effective intervention that can lower the risk of heroin-induced overdose death." | 1.32 | Overdose deaths attributed to methadone and heroin in New York City, 1990-1998. ( Bryant, WK; Galea, S; Markham Piper, T; Tardiff, KJ; Tracy, M; Vlahov, D, 2004) |
| " Daily supervised dosing by a pharmacist for the first six months resulted in significantly better treatment retention (80% vs 46%) and lower heroin use." | 1.32 | French field experience with buprenorphine. ( Auriacombe, M; Daulouède, JP; Dubernet, J; Fatséas, M; Tignol, J, 2004) |
| " The modest increase in Amsterdam is explained by low background risk of overdose mortality, low starting dosage and the low threshold to treatment." | 1.31 | An increase in overdose mortality during the first 2 weeks after entering or re-entering methadone treatment in Amsterdam. ( Buster, MC; van Brussel, GH; van den Brink, W, 2002) |
| "Methadone was the sole intoxicant in 15 cases, with a mean concentration of 0." | 1.31 | A review of methadone deaths in Jefferson County, Alabama. ( Davis, GG; Mikolaenko, I; Robinson, CA, 2002) |
| "Methadone maintenance treatments (MMTs) are the commonest substitution treatments offered to opiate addiction in Switzerland, in order to reduce criminal behaviour, infectious disease transmission and overdose death." | 1.31 | Methadone maintenance treatment, criminality and overdose-related deaths. An ecological study, 1983-1999. ( La Harpe, R; Niveau, G; Rougemont, AL, 2002) |
| "A life-time diagnosis of alcohol dependence and the number of non-fatal heroin overdoses were independent significant predictors of poorer cognitive performance." | 1.31 | Cognitive impairment among methadone maintenance patients. ( Darke, S; McDonald, S; Sims, J; Wickes, W, 2000) |
| "Alprazolam has been relatively difficult to confirm." | 1.30 | Detection of alprazolam in three cases of methadone/benzodiazepine overdose. ( Brissie, RM; Hall, MA; Robinson, CA; Rogers, WO, 1997) |
| "Methadone alone was found to be the cause of death in 50% more cases in 1989 than in 1981." | 1.29 | [Methadone and drug addicts]. ( Kringsholm, B; Steentoft, A; Worm, K, 1993) |
| "Dextropropoxyphene is a commonly used analgesic despite its high toxicity in overdose and potential for abuse and dependence." | 1.29 | The dangers of dextropropoxyphene. ( Dore, GM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (1.08) | 18.7374 |
| 1990's | 42 (11.32) | 18.2507 |
| 2000's | 108 (29.11) | 29.6817 |
| 2010's | 150 (40.43) | 24.3611 |
| 2020's | 67 (18.06) | 2.80 |
| Authors | Studies |
|---|---|
| Peterkin, A | 1 |
| Laks, J | 1 |
| Weinstein, ZM | 1 |
| Frank, CJ | 1 |
| Morrison, L | 1 |
| Edvardsen, HME | 1 |
| Clausen, T | 5 |
| Ray, B | 1 |
| Victor, G | 1 |
| Cason, R | 1 |
| Hamameh, N | 1 |
| Kubiak, S | 1 |
| Zettner, C | 1 |
| Dunnigan, M | 1 |
| Comartin, E | 1 |
| Costello, M | 1 |
| Biondi, BE | 1 |
| Vander Wyk, B | 1 |
| Schlossberg, EF | 1 |
| Shaw, A | 1 |
| Springer, SA | 1 |
| Gomes, T | 1 |
| McCormack, D | 1 |
| Bozinoff, N | 2 |
| Tadrous, M | 1 |
| Antoniou, T | 1 |
| Munro, C | 1 |
| Campbell, T | 1 |
| Paterson, JM | 1 |
| Mamdani, M | 1 |
| Sproule, B | 2 |
| Tas, B | 1 |
| Kalk, NJ | 1 |
| Lozano-García, M | 1 |
| Rafferty, GF | 2 |
| Cho, P | 1 |
| Kelleher, M | 1 |
| Moxham, J | 2 |
| Strang, J | 6 |
| Jolley, CJ | 2 |
| Jarlenski, M | 1 |
| Chen, Q | 1 |
| Gao, A | 1 |
| Rothenberger, SD | 1 |
| Krans, EE | 1 |
| Suen, LW | 1 |
| Castellanos, S | 1 |
| Joshi, N | 1 |
| Satterwhite, S | 1 |
| Knight, KR | 1 |
| Corry, B | 1 |
| Underwood, N | 1 |
| Cremer, LJ | 1 |
| Rooks-Peck, CR | 1 |
| Jones, C | 1 |
| Olfson, M | 2 |
| Waidmann, T | 1 |
| King, M | 1 |
| Pancini, V | 1 |
| Schoenbaum, M | 1 |
| Denham, A | 1 |
| Vasu, T | 1 |
| Avendano, P | 1 |
| Boslett, A | 1 |
| Mendoza, M | 1 |
| Hill, EL | 1 |
| Priest, KC | 2 |
| King, CA | 1 |
| Englander, H | 1 |
| Lovejoy, TI | 1 |
| McCarty, D | 2 |
| Jutras-Aswad, D | 1 |
| Le Foll, B | 1 |
| Ahamad, K | 1 |
| Lim, R | 1 |
| Bruneau, J | 1 |
| Fischer, B | 2 |
| Rehm, J | 2 |
| Wild, TC | 1 |
| Wood, E | 6 |
| Brissette, S | 2 |
| Gagnon, L | 1 |
| Fikowski, J | 1 |
| Ledjiar, O | 1 |
| Masse, B | 1 |
| Socias, ME | 3 |
| Jones, CM | 3 |
| Compton, WM | 2 |
| Han, B | 1 |
| Baldwin, G | 1 |
| Volkow, ND | 1 |
| Gottlieb, DJ | 1 |
| Shiner, B | 1 |
| Hoyt, JE | 1 |
| Riblet, NB | 1 |
| Peltzman, T | 2 |
| Teja, N | 1 |
| Watts, BV | 1 |
| Anwar, T | 1 |
| Duever, M | 1 |
| Jayawardhana, J | 1 |
| Andraka-Christou, B | 1 |
| Totaram, R | 1 |
| Nguyen, TD | 1 |
| Rezaeiahari, M | 1 |
| Fairman, BJ | 1 |
| Shoff, C | 1 |
| Hodges, K | 1 |
| Blanco, C | 1 |
| Losby, JL | 1 |
| Ling, SM | 1 |
| Lim, S | 1 |
| Cherian, T | 1 |
| Katyal, M | 1 |
| Goldfeld, KS | 1 |
| McDonald, R | 3 |
| Wiewel, E | 1 |
| Khan, M | 1 |
| Krawczyk, N | 2 |
| Braunstein, S | 1 |
| Murphy, SM | 2 |
| Jalali, A | 1 |
| Jeng, PJ | 1 |
| MacDonald, R | 1 |
| Lee, JD | 2 |
| Kleinman, RA | 2 |
| Sanches, M | 2 |
| Kaufman, DE | 1 |
| Kennalley, AL | 2 |
| McCall, KL | 2 |
| Piper, BJ | 2 |
| Kozak, Z | 1 |
| Ciccarone, D | 1 |
| Thrul, J | 1 |
| Cole, TO | 1 |
| Pappas, AL | 1 |
| Greenblatt, AD | 1 |
| Welsh, C | 2 |
| Yoon, M | 1 |
| Gann, D | 1 |
| Artigiani, EE | 1 |
| Wish, ED | 1 |
| Belcher, AM | 1 |
| Larney, S | 3 |
| Jones, NR | 2 |
| Hickman, M | 6 |
| Nielsen, S | 3 |
| Ali, R | 3 |
| Degenhardt, L | 9 |
| Brandt, L | 1 |
| Hu, MC | 2 |
| Liu, Y | 1 |
| Castillo, F | 1 |
| Odom, GJ | 1 |
| Balise, RR | 1 |
| Feaster, DJ | 1 |
| Nunes, EV | 2 |
| Luo, SX | 1 |
| Breland, H | 1 |
| Larkins, S | 1 |
| Antonini, V | 1 |
| Freese, T | 1 |
| McGovern, M | 1 |
| Dunn, J | 1 |
| Rawson, R | 1 |
| Racha, S | 1 |
| Patel, SM | 1 |
| Bou Harfouch, LT | 1 |
| Berger, O | 1 |
| Buresh, ME | 1 |
| Hoffman, KA | 1 |
| Thompson, E | 1 |
| Gaeta Gazzola, M | 1 |
| Oberleitner, LMS | 1 |
| Eller, A | 1 |
| Madden, LM | 2 |
| Marcus, R | 2 |
| Oberleitner, DE | 1 |
| Beitel, M | 1 |
| Barry, DT | 1 |
| Marshall, AD | 1 |
| Schroeder, SE | 1 |
| Lafferty, L | 1 |
| Drysdale, K | 1 |
| Baldry, E | 1 |
| Stoové, M | 1 |
| Dietze, P | 3 |
| Higgs, P | 1 |
| Treloar, C | 1 |
| Hughto, JMW | 1 |
| Tapper, A | 1 |
| Rapisarda, SS | 1 |
| Stopka, TJ | 2 |
| Palacios, WR | 1 |
| Case, P | 1 |
| Silcox, J | 1 |
| Moyo, P | 1 |
| Green, TC | 4 |
| Harris, RA | 1 |
| Long, JA | 1 |
| Bao, Y | 1 |
| Mandell, DS | 1 |
| Perino, J | 1 |
| Demourgues, M | 1 |
| Ramaroson, H | 1 |
| Bezin, J | 1 |
| Micallef, J | 2 |
| Miremont-Salamé, G | 1 |
| Frauger, E | 2 |
| Gilleron, V | 1 |
| Ong, N | 1 |
| Daveluy, A | 1 |
| Ali, SA | 1 |
| Shell, J | 1 |
| Harris, R | 1 |
| Bedder, M | 1 |
| Gabrhelík, R | 1 |
| Hesse, M | 1 |
| Nechanská, B | 1 |
| Handal, M | 1 |
| Mravčík, V | 1 |
| Tjagvad, C | 2 |
| Thylstrup, B | 1 |
| Seid, AK | 1 |
| Bukten, A | 1 |
| Skurtveit, S | 2 |
| Fanelli, JL | 1 |
| Furst, JA | 1 |
| Mynarski, NJ | 1 |
| Jarvis, MA | 1 |
| Nichols, SD | 1 |
| Shastry, S | 1 |
| Manini, AF | 2 |
| Richardson, LD | 1 |
| Lin, MP | 1 |
| Bahji, A | 1 |
| Cheng, B | 1 |
| Gray, S | 1 |
| Stuart, H | 1 |
| Gryczynski, J | 4 |
| Nichols, H | 1 |
| Schwartz, RP | 6 |
| Mitchell, SG | 6 |
| Hill, P | 1 |
| Wireman, K | 1 |
| Bagley, SM | 2 |
| Larochelle, MR | 3 |
| Xuan, Z | 3 |
| Wang, N | 2 |
| Patel, A | 1 |
| Bernson, D | 4 |
| Silverstein, M | 1 |
| Hadland, SE | 1 |
| Land, T | 4 |
| Samet, JH | 1 |
| Walley, AY | 5 |
| Roxburgh, A | 1 |
| Hall, WD | 2 |
| Gisev, N | 1 |
| Kelly, SM | 3 |
| O'Grady, KE | 5 |
| Sharma, A | 2 |
| Jaffe, JH | 4 |
| Quast, TC | 1 |
| Zamani, N | 9 |
| Buckley, NA | 1 |
| Hassanian-Moghaddam, H | 13 |
| Durand, L | 1 |
| O'Driscoll, D | 1 |
| Boland, F | 1 |
| Keenan, E | 1 |
| Ryan, BK | 1 |
| Barry, J | 1 |
| Bennett, K | 1 |
| Fahey, T | 2 |
| Cousins, G | 1 |
| Mojtabai, R | 1 |
| Stuart, EA | 1 |
| Fingerhood, M | 1 |
| Agus, D | 1 |
| Lyons, BC | 1 |
| Weiner, JP | 1 |
| Saloner, B | 2 |
| Lodi, S | 1 |
| Li, Y | 1 |
| Babakhanlou-Chase, H | 1 |
| Franchitto, N | 1 |
| Dong, H | 1 |
| Brar, R | 1 |
| Bach, P | 1 |
| Fairbairn, N | 4 |
| Rodríguez Mega, E | 1 |
| Simonovska, NK | 1 |
| Stefanovska, VV | 2 |
| Babulovska, A | 1 |
| Mégarbane, B | 3 |
| Chevillard, L | 3 |
| Vodovar, D | 1 |
| Fugelstad, A | 3 |
| Bremberg, S | 1 |
| Hjelmström, P | 1 |
| Thiblin, I | 2 |
| Mehrpour, O | 2 |
| Hoyte, C | 1 |
| Amirabadizadeh, A | 2 |
| Brent, J | 2 |
| Ahmad-Molaei, L | 1 |
| Pourhamzeh, M | 1 |
| Ahadi, R | 1 |
| Khodagholi, F | 1 |
| Haghparast, A | 2 |
| Kiriazova, T | 1 |
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| Hershow, RB | 1 |
| Hamilton, EL | 1 |
| Sarasvita, R | 1 |
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| Lancaster, KE | 1 |
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| Latkin, CA | 1 |
| Del Pozo, B | 1 |
| Rich, JD | 4 |
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| Al-Ani, M | 1 |
| Taha, OB | 1 |
| Radhakrishnan, NS | 1 |
| Ahmed, MM | 1 |
| Duren, T | 1 |
| Meteliuk, A | 1 |
| Galvez de Leon, SJ | 1 |
| Pykalo, I | 1 |
| Fomenko, T | 1 |
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| Montaner, J | 3 |
| Milloy, MJ | 2 |
| Williams, AR | 1 |
| Bisaga, A | 1 |
| Pincus, HA | 1 |
| Johnson, KA | 1 |
| Campbell, AN | 1 |
| Remien, RH | 1 |
| Crystal, S | 1 |
| Friedmann, PD | 1 |
| Levin, FR | 1 |
| Liebschutz, JM | 1 |
| Ma, J | 1 |
| Bao, YP | 1 |
| Wang, RJ | 1 |
| Su, MF | 1 |
| Liu, MX | 1 |
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| Peyret, E | 1 |
| Nordmann, F | 1 |
| Ben Soussen, P | 1 |
| Gisselbrecht, M | 1 |
| Lowenstein, W | 1 |
| Targosz, D | 1 |
| Szkolnicka, B | 1 |
| Radomska, M | 1 |
| Kaczmarczyk, A | 1 |
| Tyndall, MW | 1 |
| Craib, KJ | 1 |
| Currie, S | 1 |
| O'Shaughnessy, MV | 1 |
| Clarke, S | 1 |
| Dargan, P | 1 |
| Rezza, G | 1 |
| Dorrucci, M | 1 |
| Filibeck, U | 1 |
| Serafin, I | 1 |
| Weingart-Jesse, B | 1 |
| Stauber, M | 1 |
| Hiller, K | 1 |
| Jakobs, U | 1 |
| Lutz, R | 1 |
| Jensen, S | 1 |
| Gregersen, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Optimizing Patient Centered-Care: A Pragmatic Randomized Control Trial Comparing Models of Care in the Management of Prescription Opioid Misuse (OPTIMA Trial)[NCT03033732] | Phase 4 | 272 participants (Actual) | Interventional | 2017-10-02 | Completed | ||
| A Pragmatic, Multi-centre, Open-label, Randomized, 12-month, Parallel Group, Superiority Study to Compare the Effectiveness of Subcutaneous Buprenorphine Depot (Sublocade®) vs Daily Sublingual Buprenorphine With Naloxone (Suboxone®) for the Treatment of O[NCT05594121] | Phase 4 | 90 participants (Anticipated) | Interventional | 2022-12-31 | Not yet recruiting | ||
| A Randomized Trial of Interim Methadone and Patient Navigation Initiated in Jail[NCT02334215] | 225 participants (Actual) | Interventional | 2014-12-15 | Completed | |||
| INTEGRA: A Vanguard Study of Health Service Delivery in a Mobile Health Delivery Unit to Link Persons Who Inject Drugs to Integrated Care and Prevention for Addiction, HIV, HCV and Primary Care[NCT04804072] | 450 participants (Anticipated) | Interventional | 2021-06-02 | Enrolling by invitation | |||
| Using Difference-in-Differences to Evaluate the Effect of a Statewide Quality Improvement Program on New Persistent Opioid Use After Surgery[NCT04805229] | 30,000 participants (Actual) | Observational | 2013-01-01 | Completed | |||
| Test of a Workforce Development Intervention to Expand Buprenorphine Prescribers[NCT02926482] | 76 participants (Actual) | Interventional | 2016-10-26 | Completed | |||
| PRevention Of Methamphetamine Use Among Postpartum Women Trial (PROMPT)[NCT05128071] | Early Phase 1 | 40 participants (Anticipated) | Interventional | 2022-02-04 | Recruiting | ||
| Extended-Release Naltrexone Opioid Treatment at Jail Re-Entry[NCT01999946] | Phase 4 | 217 participants (Actual) | Interventional | 2014-06-27 | Completed | ||
| Comparing Opioid Prescription Patterns in Total Joint Arthroplasty Patients: A Randomized Controlled Trial[NCT03236155] | Phase 4 | 304 participants (Actual) | Interventional | 2017-07-01 | Completed | ||
| Multimodal Anesthesia and Analgesia for Total Shoulder and Reverse Total Shoulder Arthroplasty: A Randomized Controlled Trial[NCT03586934] | Phase 3 | 0 participants (Actual) | Interventional | 2018-06-01 | Withdrawn (stopped due to Difficult to enroll patients for the study) | ||
| North American Opiate Medication Initiative (NAOMI): Multi-Centre, Randomized Controlled Trial of Heroin-Assisted Therapy for Treatment-Refractory Injection Opiate Users[NCT00175357] | Phase 3 | 192 participants (Actual) | Interventional | 2005-03-31 | Completed | ||
| SALOME: Multi-Centre, Double Blind Randomized Controlled Trial Comparing The Effectiveness Of Diacetylmorphine Vs. Hydromorphone For The Treatment Of Long-Term Injection Opioid Users Who Do Not Benefit From Available Therapies[NCT01447212] | Phase 3 | 202 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| Evaluation of the Efficacy and Mechanisms of a Novel Intervention for Chronic Pain Tailored to People Living With HIV[NCT03692611] | 280 participants (Actual) | Interventional | 2019-08-14 | Active, not recruiting | |||
| The Behavioral Activation for Chinese Substance Users (C-BA) Research Protocol[NCT03705143] | 90 participants (Actual) | Interventional | 2018-06-04 | Completed | |||
| Four Models of Telephone Support for Stimulant Recovery[NCT00744068] | 302 participants (Actual) | Interventional | 2006-04-30 | Completed | |||
| Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone in Human Subjects[NCT00504413] | Phase 1 | 20 participants (Anticipated) | Interventional | 2007-07-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Cost in US Dollars of substance abuse services on the modified Substance Abuse Services Cost Analysis Program (NCT02334215)
Timeframe: 12 months post-release from incarceration
| Intervention | US Dollars (Mean) |
|---|---|
| Methadone Plus Patient Navigation | 3052 |
| Methadone | 2377 |
| Enhanced Treatment as Usual | 1884 |
Mean number of days hospitalized during the 12 months post-release from incarceration (NCT02334215)
Timeframe: 12 months post-release from incarceration
| Intervention | Days (Mean) |
|---|---|
| Methadone Plus Patient Navigation | 2.0 |
| Methadone | 3.4 |
| Enhanced Treatment as Usual | 1.2 |
Official data on participant arrests subsequent to release from index incarceration. (NCT02334215)
Timeframe: one year post-release from incarceration
| Intervention | Participants (Count of Participants) |
|---|---|
| Methadone Plus Patient Navigation | 32 |
| Methadone | 39 |
| Enhanced Treatment as Usual | 36 |
Predicted probability derived from the general linear mixed model of self-reported entry into treatment for opioid use disorder following release from incarceration and being in treatment 30 days post-release (0= no entry in treatment; 1= entry in treatment). (NCT02334215)
Timeframe: 30 days post-release from incarceration
| Intervention | Probability (Least Squares Mean) |
|---|---|
| Methadone Plus Patient Navigation | 0.65 |
| Methadone | 0.62 |
| Enhanced Treatment as Usual | 0.225 |
Drug Risk Scale Score on the Risk Assessment Battery. The scale's range goes from 0 to 22. Higher score represents greater frequency of drug risk behaviors (NCT02334215)
Timeframe: Baseline and 6, and 12 months post-release from incarceration
| Intervention | score on a scale (Least Squares Mean) | ||
|---|---|---|---|
| Baseline | 6 month post-release from incarceration | 12 month post-release | |
| Enhanced Treatment as Usual | 3.11 | 2.16 | 1.03 |
| Methadone | 2.43 | 1.81 | 1.35 |
| Methadone Plus Patient Navigation | 2.30 | 1.52 | .50 |
Environmental domain score on the World Health Organization Quality of Life Scale (WHOQOL-BREF) goes from 1 to 100. A higher score represents a better quality of life. (NCT02334215)
Timeframe: 1, 3, 6, and 12 months post-release from incarceration
| Intervention | score on a scale (Least Squares Mean) | ||||
|---|---|---|---|---|---|
| Baseline | 1 months post-release from incarceration | 3 months post-release from incarceration | 6 months post-release from incarceration | 12 months post-release from incarceration | |
| Enhanced Treatment as Usual | 54.9 | 65.1 | 63.7 | 57.2 | 59.3 |
| Methadone | 54.6 | 63.6 | 55.1 | 60.6 | 59.4 |
| Methadone Plus Patient Navigation | 48.0 | 56.1 | 51.9 | 59.0 | 54.8 |
Mean number of days reported by participants of their criminal activity during the 30 days preceding the Addiction Severity Index interviews (NCT02334215)
Timeframe: 1, 3, 6, and 12 months post-release from incarceration
| Intervention | Days (Least Squares Mean) | |||
|---|---|---|---|---|
| 1 month post-release from incarceration | 3 months post-release from incarceration | 6 months post-release from incarceration | 12 months post-release from incarceration | |
| Enhanced Treatment as Usual | 8.22 | 10.59 | 11.49 | 10.18 |
| Methadone | 8.18 | 9.35 | 9.74 | 9.97 |
| Methadone Plus Patient Navigation | 5.22 | 9.79 | 9.24 | 6.88 |
Mean number of participant self-reported days of heroin use in the 30 days preceding the interview on the Addiction Severity Index (ASI) (NCT02334215)
Timeframe: 1, 3, 6, and 12 months post-release from incarceration
| Intervention | Days (Least Squares Mean) | |||
|---|---|---|---|---|
| 1 month post-release from incarceration | 3 months post-release from incarceration | 6 months post-release from incarceration | 12 months post-release from incarceration | |
| Enhanced Treatment as Usual | 14.88 | 16.18 | 15.42 | 15.35 |
| Methadone | 12.07 | 15.15 | 14.02 | 14.70 |
| Methadone Plus Patient Navigation | 8.66 | 13.46 | 13.56 | 12.35 |
Self report quality of life as reported by participants following release from their index incarceration on a scale from 1 to 5. A higher score is a better outcome. (NCT02334215)
Timeframe: 1, 3, 6, and 12 month post-release from incarceration
| Intervention | units on a scale (Least Squares Mean) | ||||
|---|---|---|---|---|---|
| Baseline | 1 month post-release from incarceration | 3 months post-release from incarceration | 6 months post-release from incarceration | 12 months post-release from incarceration | |
| Enhanced Treatment as Usual | 3.1 | 3.40 | 3.57 | 3.53 | 3.45 |
| Methadone | 2.8 | 3.56 | 3.46 | 3.58 | 3.43 |
| Methadone Plus Patient Navigation | 2.7 | 3.49 | 3.15 | 3.51 | 3.29 |
Participant self-reported mean number of days of cocaine use in the 30 days preceding the interview on the Addiction Severity Index (ASI) (NCT02334215)
Timeframe: 1, 3, 6, and 12 months post-release from incarceration
| Intervention | Days (Least Squares Mean) | |||
|---|---|---|---|---|
| 1 month post-release from incarceration | 3 months post-release from incarceration | 6 months post-release from incarceration | 12 months post-release from incarceration | |
| Enhanced Treatment as Usual | 11.01 | 11.94 | 11.94 | 12.63 |
| Methadone | 9.05 | 11.32 | 13.57 | 14.46 |
| Methadone Plus Patient Navigation | 5.95 | 8.83 | 10.74 | 9.60 |
The score on the Physical Domain Scale of the World Health Organization Quality of Life Scale-BREF (WHOQOL-BREF). The scales range is from 0 to 100. The higher score represents better quality of life. (NCT02334215)
Timeframe: 1, 3, 6, and 12 months post-incarceration
| Intervention | score on a scale (Least Squares Mean) | ||||
|---|---|---|---|---|---|
| Baseline | 1 months post-release from incarceration | 3 months post-release from incarceration | 6 months post-release from incarceration | 12 months post-release from incarceration | |
| Enhanced Treatment as Usual | 57.1 | 68.7 | 67.3 | 61.2 | 60.3 |
| Methadone | 58.3 | 62.2 | 60.1 | 66.3 | 63.8 |
| Methadone Plus Patient Navigation | 54.6 | 62.8 | 60.3 | 68.6 | 63.1 |
Predicted probability derived from the Generalized Linear Mixed Model of meeting the Data and Statistical Manual - 5 criteria for Opioid Use Disorder in response to modified CIDI interview (0= does not meet criteria; 1= meets criteria). (NCT02334215)
Timeframe: one month period prior to the 3, 6, and 12 month post-release from incarceration
| Intervention | Probability (Least Squares Mean) | ||
|---|---|---|---|
| 3 months post-release from incarceration | 6 months post-release from incarceration | 12 months post-release from incarceration | |
| Enhanced Treatment as Usual | 0.76 | 0.77 | 0.59 |
| Methadone | 0.70 | 0.59 | 0.77 |
| Methadone Plus Patient Navigation | 0.66 | 0.51 | 0.54 |
Predicted Probability derived from the Generalized Linear Mixed of self-reported enrolled in treatment for Opioid Use Disorder at the time of the follow-up interview (0=not enrolled; 1=enrolled). (NCT02334215)
Timeframe: 12 months post-release from incarceration
| Intervention | Probability (Least Squares Mean) | |||
|---|---|---|---|---|
| 1 month post-release from incarceration | 3 months post-release from incarceration | 6 months post-release from incarceration | 12 months post-release from incarceration | |
| Enhanced Treatment as Usual | .26 | .19 | .24 | .29 |
| Methadone | .56 | .47 | .52 | .27 |
| Methadone Plus Patient Navigation | .63 | .57 | .52 | .40 |
Predicted Probability Derived from the Generalized Linear Mixed Model meeting Data and Statistical Manual - 5 criteria for Cocaine Use Disorder on the modified Composite International Diagnostic Interview (CIDI) (0=Does not meet criteria; 1=meets criteria). (NCT02334215)
Timeframe: 3, 6, and 12 months post-release from incarceration
| Intervention | Probability (Least Squares Mean) | ||
|---|---|---|---|
| 3 months post-release from incarceration | 6 months post-release from incarceration | 12 months post-release from incarceration | |
| Enhanced Treatment as Usual | .32 | .36 | .30 |
| Methadone | .32 | .35 | .40 |
| Methadone Plus Patient Navigation | .20 | .22 | .32 |
Predicted probability derived from the generalized linear mixed model opioid positive urine tests (0= negative; 1- positive) for heroin, oxycodone, methadone, or buprenorphine -- excluding the latter two positives when they results from prescribed medications to treat opioid use disorder) (NCT02334215)
Timeframe: 1, 3, 6, and 12 months post-release from incarceration
| Intervention | Probability (Least Squares Mean) | |||
|---|---|---|---|---|
| 1 month post-release from incarceration | 3 months post-release from incarceration | 6 months post-release from incarceration | 12 months post-release from incarceration | |
| Enhanced Treatment as Usual | 0.66 | 0.73 | 0.71 | 0.59 |
| Methadone | 0.72 | 0.72 | 0.63 | 0.71 |
| Methadone Plus Patient Navigation | 0.70 | 0.59 | 0.49 | 0.46 |
Scale score on the Psychological Domain on the World Health Organization Quality of Life Scale (WHOQOL-BREF) goes from 1 to 100. The higher score represents a better quality of life. (NCT02334215)
Timeframe: 1, 3, 6, and 12 months post-release from incarceration
| Intervention | score on a scale (Least Squares Mean) | ||||
|---|---|---|---|---|---|
| Baseline | 1 month post-release from incarceration | 3 months post-release from incarceration | 6 months post-release from incarceration | 12 months post-release from incarceration | |
| Enhanced Treatment as Usual | 55.9 | 66.7 | 66.6 | 64.8 | 64.4 |
| Methadone | 56.9 | 64.0 | 61.2 | 63.9 | 61.8 |
| Methadone Plus Patient Navigation | 56.8 | 65.5 | 62.6 | 64.9 | 62.0 |
Sex Risk Score on the Risk Assessment Battery (RAB). Higher scores represents greater risk. The score ranges from 0 to 18. (NCT02334215)
Timeframe: Baseline and 6, and 12 months post-release from incarceration
| Intervention | score on a scale (Least Squares Mean) | ||
|---|---|---|---|
| Baseline | 6 months post-release | 12 month post-release | |
| Enhanced Treatment as Usual | 4.68 | 4.27 | 4.17 |
| Methadone | 4.78 | 3.94 | 4.61 |
| Methadone Plus Patient Navigation | 4.52 | 3.93 | 3.78 |
Social domain scale score on the World Health Organization Quality of Life Scale (WHOQOL-BREF) goes from 1 to 100. The higher score represents a better quality of life. (NCT02334215)
Timeframe: 1, 3, 6, and 12 month post-release from incarceration
| Intervention | score on a scale (Least Squares Mean) | ||||
|---|---|---|---|---|---|
| Baseline | 1 month post-release from incarceration | 3 months post-release from incarceration | 6 months post-release from incarceration | 12 months post-release from incarceration | |
| Enhanced Treatment as Usual | 51.3 | 64.9 | 66.4 | 58.8 | 59.1 |
| Methadone | 57.7 | 57.5 | 62.4 | 63.3 | 55.4 |
| Methadone Plus Patient Navigation | 56.9 | 63.6 | 60.9 | 63.3 | 56.6 |
Our primary aim is to compare time-to-relapse among participants treated with XR-NTX vs. randomized ETAU following release from jail measured up to 24 weeks by Urine Toxicology results and self-report on the TLFB. (NCT01999946)
Timeframe: up to 24 weeks
| Intervention | Weeks (Mean) |
|---|---|
| Extended-Release Naltrexone (XR-NTX) | 8.6 |
| Enhanced Treatment As Usual (ETAU) | 5.9 |
This will be done as monitored through the Illinois prescription monitoring program, collecting data on each patient enrolled to be sure that patients do not receive additional narcotic prescriptions beyond what is provided to them as part of the study. (NCT03236155)
Timeframe: 90 days
| Intervention | Number of Compliant Participants (Number) |
|---|---|
| 90 (5mg OxyIR) Pills Prescribed | 143 |
| 30 (5mg OxyIR) Pills Prescribed | 161 |
Complications will be recorded as follows post-operatively for 90 days following surgery; any patient that has a DVT/Pulmonary embolism, any return to the operating room within 90-days, any re-admission to the hospital within 90-days, Any report of superficial infection, any report of deep infection, a periprosthetic fracture of the joint replaced, cerebrovascular accident or transient ischemic attack, report of dislocation, or patients who report opioid withdrawal. (NCT03236155)
Timeframe: 90 days from time of surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| 90 (5mg OxyIR) Pills Prescribed | 0 |
| 30 (5mg OxyIR) Pills Prescribed | 0 |
Self-reported by patient, we are asking for the number of Oxycodone taken by patients (5mg doses). This will be verified with patient bringing their pill bottle in and counted by a study investigator. (NCT03236155)
Timeframe: 30 days
| Intervention | Morphine Milligram Equivalents (MME) (Mean) |
|---|---|
| 90 (5mg OxyIR) Pills Prescribed | 1089.7 |
| 30 (5mg OxyIR) Pills Prescribed | 777.1 |
"304 opioid naïve patients undergoing THA or TKA between August 2017 and April 2018, reporting number of pills not used~Illinois prescription monitoring program- utilized to confirm no other physician prescribed opiates to the participating patients. They were asked at each visit regarding unused medications and brought to the office to properly dispose." (NCT03236155)
Timeframe: 90 days
| Intervention | Unused pills (Median) |
|---|---|
| 90 (5mg OxyIR) Pills Prescribed | 73 |
| 30 (5mg OxyIR) Prescribed | 15 |
Using the primary outcome of number of opioids taken by the patients while inpatient, those will be converted into morphine equivalents. This was obtained from the hospital chart during the patient's inpatient stay. (NCT03236155)
Timeframe: from time of surgery to discharge from hospital (1 day - 2 weeks)
| Intervention | Morphine Equivalent while inpatient (Mean) |
|---|---|
| 90 (5mg OxyIR) Pills Prescribed | 64.6 |
| 30 (5 mg OxyIR) Pills Prescribed | 72.2 |
Using a Defense and Veterans Pain Rating scale, patients were asked from date of surgery to the date of discharge for daily inpatient pain scores. This is a pain assessment tool, using numerical rating scale, 0 (no pain), 1, 2, and 3 (mild), 4, 5, and 6 (moderate), 7, 8, and 9 (severe) to 10 (worst pain possible). The higher the score, the more pain. (NCT03236155)
Timeframe: assessed daily from time of surgery to discharge from hospital (1 days - 2 weeks), Day 14 scores reported
| Intervention | score on a scale (Mean) |
|---|---|
| 90 (5mg OxyIR) Prescribed | 4 |
| 30 (5mg OxyIR) Prescribed | 4.5 |
Utilizing the defense & veterans pain rating scale, patients enrolled will be asked at multiple time points after surgery regarding their pain. This is a pain assessment tool, using numerical rating scale, 0 (no pain), 1, 2, and 3 (mild), 4, 5, and 6 (moderate), 7, 8, and 9 (severe) to 10 (worst pain possible). The higher the score, the more pain. (NCT03236155)
Timeframe: Days 1-3, 1 week, 2 weeks, and 3-4 weeks post discharge from surgery
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Days 1-3 after discharge | Week 1 after discharge | Week 2 after discharge | Weeks 3-4 after discharge | |
| 30 (5mg OxyIR) Pills Prescribed | 4.3 | 4.1 | 3.1 | 2.2 |
| 90 (5mg OxyIR) Pills Prescribed | 4.0 | 3.9 | 3.3 | 2.2 |
"Postoperative total hip and total knee arthroplasty patient reported outcomes at 90 days (All reported as scores on a scale, ranges below.). For hips: Hip Disability and Osteoarthritis Outcome Score Joint Replacement (Hoos Jr), for knees: Knee Injury and Osteoarthritis Outcome Score, Joint Replacement, (Koos Jr), additionally, all will complete the Veterans Rand-12 outcome (VR-12). All outcomes, closer to 100 are better outcomes.~HOOS, JR: Questions coded 0 - 4 points, none - extreme pain, scored by summing responses (range 0-24), convert to t-score. Answer ranges 0 - 100 (0 - total hip disability, 100 -perfect hip health).~KOOS, Jr: Same but for Knees VR-12: Assesses physical functioning, physical/ mental limitations. Scored as summary of mental/physical, measure in standard deviations out of 100 points, where a score of 100 shows a patient's health functioning physically and mentally at their their best, zero represents a worse outcome." (NCT03236155)
Timeframe: 90 days post operative (higher values represent better functioning total hip or total knee replacements).
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Postop Koos Jr | Postop Hoos Jr | Postop VR-12 | |
| 30 (5mg OxyIR) Pills Prescribed | 65.0 | 73.7 | 92.1 |
| 90 (5mg OxyIR) Pills Prescribed | 65.9 | 73.5 | 93.2 |
"Utilizing Preop Koos Jr, Preop Hoos Jr, and Pre operative VR-12, all subjects will be asked to provide a pre-operative patient reported outcome to compare to post-operative patient reported outcomes. All reported as scores on a scale, ranges below.~HOOS, JR: Questions coded 0 to 4 points, none to extreme pain, scored by summing responses (range of 0-24), convert to interval score ranges 0 to 100 (0 - total hip disability, 100 -perfect hip health).~KOOS, Jr: Same but for Knees VR-12: Assesses physical functioning, physical/ mental limitations. Scored as summary of mental and physical, measure in standard deviations. The scale range is 0 to 100, where a score of 100 represents the best physical and mental health and zero is the worst outcome." (NCT03236155)
Timeframe: 10 days prior to surgery (higher values represent better functioning total hip or total knee replacements).
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| Preop Koos Jr | Preop Hoos Jr | Preop VR-12 | |
| 30 (5mg OxyIR) Pills Prescribed | 51.5 | 50.7 | 89.1 |
| 90 (5mg OxyIR) Pills Prescribed | 49.3 | 53.2 | 90.8 |
33 reviews available for methadone and Drug Overdose
| Article | Year |
|---|---|
Current Best Practices for Acute and Chronic Management of Patients with Opioid Use Disorder.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Comorbidity; Disease Management; Drug Overdose; Female; Fe | 2022 |
Reduction in mortality risk with opioid agonist therapy: a systematic review and meta-analysis.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Case-Control Studies; Cohort Studies; Databases, Factual; | 2019 |
Quetiapine and other antipsychotics combined with opioids in legal autopsy cases: A random finding or cause of fatal outcome?
Topics: Adolescent; Adult; Analgesics, Opioid; Animals; Antipsychotic Agents; Arrhythmias, Cardiac; Autopsy; | 2021 |
The impact of COVID-19 on healthcare delivery for people who use opioids: a scoping review.
Topics: Buprenorphine; COVID-19; Cross-Sectional Studies; Drug Overdose; Emergency Medical Services; Health | 2021 |
Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies.
Topics: Buprenorphine; Drug Overdose; Humans; Methadone; Narcotics; Opiate Substitution Treatment; Opioid-Re | 2017 |
Opioid Use Disorders: Perioperative Management of a Special Population.
Topics: Analgesics, Opioid; Buprenorphine; Drug Overdose; Drug Tolerance; Humans; Interdisciplinary Communic | 2018 |
Developing an opioid use disorder treatment cascade: A review of quality measures.
Topics: Analgesics, Opioid; Buprenorphine; Drug Overdose; Humans; Methadone; Naltrexone; Narcotic Antagonist | 2018 |
Effects of medication-assisted treatment on mortality among opioids users: a systematic review and meta-analysis.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cohort Studies; Drug Overdose; Female; Humans; Male; Metha | 2019 |
Supervised Injectable Opioid Treatment for the Management of Opioid Dependence.
Topics: Analgesics, Opioid; Drug Overdose; Follow-Up Studies; Heroin; Humans; Methadone; Opiate Substitution | 2018 |
Postmortem Hyperthermia: Two Case Reports and a Review of the Literature.
Topics: Adult; Drug Overdose; Female; Fever; Humans; Male; Methadone; N-Methyl-3,4-methylenedioxyamphetamine | 2018 |
Prevention of Opioid Overdose.
Topics: Analgesics, Opioid; Buprenorphine; Chronic Pain; Drug Overdose; Humans; Methadone; Naloxone; Narcoti | 2019 |
Methadone overdose and cardiac arrhythmia potential: findings from a review of the evidence for an American Pain Society and College on Problems of Drug Dependence clinical practice guideline.
Topics: Arrhythmias, Cardiac; Chronic Pain; Drug Overdose; Humans; Methadone; Opioid-Related Disorders; Prac | 2014 |
Opioid Therapy and Sleep Disorders: Risks and Mitigation Strategies.
Topics: Analgesics, Opioid; Benzodiazepines; Chronic Pain; Drug Overdose; Humans; Methadone; Sleep Wake Diso | 2015 |
Caring for patients with opioid use disorder in the hospital.
Topics: Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Dru | 2016 |
[Methadone treatment and its dangers].
Topics: Adult; Analgesics, Opioid; Child, Preschool; Drug Interactions; Drug Overdose; Electrocardiography; | 2009 |
[Mechanisms of opioid-induced overdose: experimental approach to clinical concerns].
Topics: Analgesics, Opioid; Animals; Buprenorphine; Drug Interactions; Drug Overdose; France; Humans; Methad | 2009 |
Methadone deaths: risk factors in pain and addicted populations.
Topics: Analgesics, Opioid; Chronic Disease; Death, Sudden, Cardiac; Drug Overdose; Humans; Methadone; Opiat | 2010 |
The anesthetic implications of illicit opioid abuse.
Topics: Analgesics, Opioid; Anesthesia; Drug Overdose; Humans; Methadone; Opioid-Related Disorders | 2011 |
Post-mortem decapitation by domestic dogs: three case reports and review of the literature.
Topics: Animals; Bites and Stings; Cocaine; Decapitation; Dogs; Drug Overdose; Esophageal and Gastric Varice | 2011 |
A review of forensic implications of opioid prescribing with examples from malpractice cases involving opioid-related overdose.
Topics: Analgesics, Opioid; Chronic Disease; Drug Overdose; Drug Prescriptions; Forensic Medicine; Humans; K | 2011 |
Pharmacological maintenance treatments of opiate addiction.
Topics: Buprenorphine; Drug Overdose; Heroin; Heroin Dependence; Humans; Methadone; Opiate Substitution Trea | 2014 |
Characterization of methadone overdose: clinical considerations and the scientific evidence.
Topics: Depression; Diagnosis, Differential; Drug Overdose; Drug Tolerance; Forensic Medicine; Humans; Metha | 2002 |
Strategies for preventing heroin overdose.
Topics: Analgesics, Opioid; Drug Overdose; Heroin; Heroin Dependence; Humans; Methadone; Naloxone; Narcotic | 2003 |
The effects of methadone and its role in fatalities.
Topics: Cause of Death; Drug Interactions; Drug Overdose; Humans; Metabolic Clearance Rate; Methadone; Narco | 2004 |
Review article: perioperative pain management of patients on methadone therapy.
Topics: Drug Interactions; Drug Overdose; Humans; Methadone; Opioid-Related Disorders; Pain, Postoperative | 2005 |
Are one or two dangerous? Opioid exposure in toddlers.
Topics: Analgesics, Opioid; Child, Preschool; Codeine; Dose-Response Relationship, Drug; Drug Overdose; Emer | 2005 |
Harm reduction the key to managing problem drug users.
Topics: Analgesics, Opioid; Drug Overdose; Harm Reduction; Humans; Methadone; Substance Abuse Detection; Sub | 2007 |
Methadone maintenance and addicts' risk of fatal heroin overdose.
Topics: Accidents; Adult; Cohort Studies; Drug Overdose; Female; Follow-Up Studies; Heroin; Heroin Dependenc | 1996 |
[A case of the adult respiratory distress syndrome induced by a methadone overdose].
Topics: Adult; Drug Overdose; Humans; Lung; Male; Methadone; Narcotics; Pneumonia, Bacterial; Radiography, T | 1997 |
[Drug-related emergencies with opiates].
Topics: Drug Overdose; Emergencies; Heroin Dependence; Humans; Internal Medicine; Methadone; Narcotics; Opio | 1999 |
Methadone: where are we now?
Topics: Drug Overdose; Humans; Methadone; Narcotics; Substance Abuse, Intravenous | 1999 |
Safe approaches to treating drug addiction.
Topics: Drug Overdose; Family Practice; Humans; Methadone; Naltrexone; Narcotic Antagonists; Narcotics; Sorp | 2000 |
Death attributed to methadone.
Topics: Analgesics, Opioid; Cause of Death; Drug Overdose; Humans; Methadone | 2001 |
12 trials available for methadone and Drug Overdose
| Article | Year |
|---|---|
Flexible Buprenorphine/Naloxone Model of Care for Reducing Opioid Use in Individuals With Prescription-Type Opioid Use Disorder: An Open-Label, Pragmatic, Noninferiority Randomized Controlled Trial.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Canada; Drug Ove | 2022 |
Methadone treatment of arrestees: A randomized clinical trial.
Topics: Adult; Analgesics, Opioid; Baltimore; Drug Overdose; Female; Humans; Male; Methadone; Middle Aged; O | 2020 |
Buprenorphine to reverse respiratory depression from methadone overdose in opioid-dependent patients: a prospective randomized trial.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Overdose; Female; Humans; Male; Methadone; Middle Age | 2020 |
Slow release oral morphine versus methadone for opioid use disorder in the fentanyl era (pRESTO): Protocol for a non-inferiority randomized clinical trial.
Topics: Adult; Cost-Benefit Analysis; Delayed-Action Preparations; Drug Overdose; Equivalence Trials as Topi | 2020 |
Randomized trial of methadone treatment of arrestees: 24-month post-release outcomes.
Topics: Adult; Analgesics, Opioid; Baltimore; Cocaine-Related Disorders; Costs and Cost Analysis; Crime; Dru | 2021 |
Comparison of Two Naloxone Regimens in Opioid-dependent Methadoneoverdosed Patients: A Clinical Trial Study.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Overdose; Female | 2017 |
The effect of Housing First on adherence to methadone maintenance treatment.
Topics: Adult; Community Mental Health Services; Drug Overdose; Female; Housing; Humans; Ill-Housed Persons; | 2018 |
Clinical and radiological findings in methadone-induced delayed leukoencephalopathy.
Topics: Activities of Daily Living; Adult; Brain; Drug Overdose; Electroencephalography; Humans; Inpatients; | 2014 |
Extended-release naltrexone opioid treatment at jail reentry (XOR).
Topics: Analgesics, Opioid; Cause of Death; Delayed-Action Preparations; Drug Overdose; Humans; Injections, | 2016 |
Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer-Related Pain: The EQUIMETH2 Trial (Methadone for Cancer-Related Pain).
Topics: Analgesics, Opioid; Breakthrough Pain; Cancer Pain; Drug Overdose; Female; Follow-Up Studies; Humans | 2016 |
Diacetylmorphine versus methadone for the treatment of opioid addiction.
Topics: Administration, Oral; Adult; Cocaine-Related Disorders; Double-Blind Method; Drug Overdose; Female; | 2009 |
Diacetylmorphine versus methadone for the treatment of opioid addiction.
Topics: Administration, Oral; Adult; Cocaine-Related Disorders; Double-Blind Method; Drug Overdose; Female; | 2009 |
Diacetylmorphine versus methadone for the treatment of opioid addiction.
Topics: Administration, Oral; Adult; Cocaine-Related Disorders; Double-Blind Method; Drug Overdose; Female; | 2009 |
Diacetylmorphine versus methadone for the treatment of opioid addiction.
Topics: Administration, Oral; Adult; Cocaine-Related Disorders; Double-Blind Method; Drug Overdose; Female; | 2009 |
Patterns of nonfatal heroin overdose over a 3-year period: findings from the Australian treatment outcome study.
Topics: Adolescent; Adult; Buprenorphine; Cohort Studies; Drug Overdose; Episode of Care; Female; Follow-Up | 2007 |
326 other studies available for methadone and Drug Overdose
| Article | Year |
|---|---|
Harm Reduction for Patients With Substance Use Disorders.
Topics: Adult; Buprenorphine; Contraception; Drug Overdose; Female; Harm Reduction; Heroin; Humans; Male; Me | 2022 |
Opioid related deaths in Norway in 2000-2019.
Topics: Analgesics, Opioid; Drug Overdose; Female; Heroin; Humans; Illicit Drugs; Male; Methadone | 2022 |
Developing a cascade of care for opioid use disorder among individuals in jail.
Topics: Analgesics, Opioid; Buprenorphine; Drug Overdose; Humans; Jails; Methadone; Opiate Substitution Trea | 2022 |
Factors associated with retention on medications for opioid use disorder among a cohort of adults seeking treatment in the community.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Overdose; Female; Humans; Male; Methadone; Naltrexone | 2022 |
Duration of use and outcomes among people with opioid use disorder initiating methadone and buprenorphine in Ontario: a population-based propensity-score matched cohort study.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Cohort Studies; Drug Ov | 2022 |
Undetected Respiratory Depression in People with Opioid Use Disorder.
Topics: Analgesics, Opioid; Buprenorphine; Carbon Dioxide; Drug Overdose; Humans; Methadone; Opiate Substitu | 2022 |
Association of Duration of Methadone or Buprenorphine Use During Pregnancy With Risk of Nonfatal Drug Overdose Among Pregnant Persons With Opioid Use Disorder in the US.
Topics: Buprenorphine; Drug Overdose; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Relat | 2022 |
"The idea is to help people achieve greater success and liberty": A qualitative study of expanded methadone take-home access in opioid use disorder treatment.
Topics: Analgesics, Opioid; COVID-19; Drug Overdose; Female; Freedom; Humans; Male; Methadone; Middle Aged; | 2022 |
County-level sociodemographic differences in availability of two medications for opioid use disorder: United States, 2019.
Topics: Analgesics, Opioid; Buprenorphine; Drug Overdose; Humans; Methadone; Opiate Substitution Treatment; | 2022 |
Population-Based Opioid Prescribing and Overdose Deaths in the USA: an Observational Study.
Topics: Analgesics, Opioid; Drug Overdose; Fentanyl; Humans; Methadone; Practice Patterns, Physicians'; Unit | 2023 |
Coroner county systems are associated with a higher likelihood of unclassified drug overdoses compared to medical examiner county systems.
Topics: Analgesics, Opioid; Coroners and Medical Examiners; Drug Overdose; Heroin; Humans; Methadone; Opiate | 2022 |
Differences in the delivery of medications for opioid use disorder during hospitalization by racial categories: A retrospective cohort analysis.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Buprenorphine; COVID-19; Drug Overdose; Female; | 2022 |
Methadone-Involved Overdose Deaths in the US Before and After Federal Policy Changes Expanding Take-Home Methadone Doses From Opioid Treatment Programs.
Topics: Analgesics, Opioid; Drug Overdose; Humans; Methadone; Opiate Overdose; Opiate Substitution Treatment | 2022 |
A comparison of mortality rates for buprenorphine versus methadone treatments for opioid use disorder.
Topics: Buprenorphine; Drug Overdose; Female; Humans; Male; Methadone; Middle Aged; Opiate Substitution Trea | 2023 |
Access to methadone clinics and opioid overdose deaths in Georgia: A geospatial analysis.
Topics: Analgesics, Opioid; Drug Overdose; Georgia; Humans; Methadone; Opiate Overdose; Opiate Substitution | 2022 |
Comprehensive analysis of discharge reasons from methadone outpatient treatment programs.
Topics: Analgesics, Opioid; Drug Overdose; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related | 2022 |
Impact of COVID-19 on the characteristics of opioid overdose deaths in Arkansas.
Topics: Analgesics, Opioid; Arkansas; COVID-19; Drug Overdose; Fentanyl; Humans; Methadone; Methamphetamine; | 2022 |
Receipt of Telehealth Services, Receipt and Retention of Medications for Opioid Use Disorder, and Medically Treated Overdose Among Medicare Beneficiaries Before and During the COVID-19 Pandemic.
Topics: Aged; Analgesics, Opioid; Buprenorphine; COVID-19; Drug Overdose; Female; Humans; Longitudinal Studi | 2022 |
Association between jail-based methadone or buprenorphine treatment for opioid use disorder and overdose mortality after release from New York City jails 2011-17.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Overdose; Female; Humans; Jails; Male; Methadone; New | 2023 |
Methadone-involved overdose deaths in the United States before and during the COVID-19 pandemic.
Topics: Analgesics, Opioid; COVID-19; Disease Progression; Drug Overdose; Humans; Methadone; Opiate Overdose | 2023 |
Methadone-involved overdose deaths in the United States before and during the COVID-19 pandemic.
Topics: Analgesics, Opioid; COVID-19; Disease Progression; Drug Overdose; Humans; Methadone; Opiate Overdose | 2023 |
Methadone-involved overdose deaths in the United States before and during the COVID-19 pandemic.
Topics: Analgesics, Opioid; COVID-19; Disease Progression; Drug Overdose; Humans; Methadone; Opiate Overdose | 2023 |
Methadone-involved overdose deaths in the United States before and during the COVID-19 pandemic.
Topics: Analgesics, Opioid; COVID-19; Disease Progression; Drug Overdose; Humans; Methadone; Opiate Overdose | 2023 |
Examination of methadone involved overdoses during the COVID-19 pandemic.
Topics: Analgesics, Opioid; COVID-19; Drug Overdose; Humans; Methadone; Opiate Overdose; Opioid-Related Diso | 2023 |
Harm reduction behaviors are associated with carrying naloxone among patients on methadone treatment.
Topics: Analgesics, Opioid; Drug Overdose; Harm Reduction; Humans; Male; Methadone; Middle Aged; Naloxone; N | 2023 |
Does opioid agonist treatment reduce overdose mortality risk in people who are older or have physical comorbidities? Cohort study using linked administrative health data in New South Wales, Australia, 2002-17.
Topics: Aged; Analgesics, Opioid; Australia; Buprenorphine; Cohort Studies; Drug Overdose; Humans; Methadone | 2023 |
Risk of Experiencing an Overdose Event for Patients Undergoing Treatment With Medication for Opioid Use Disorder.
Topics: Buprenorphine; Drug Overdose; Humans; Methadone; Naltrexone; Narcotic Antagonists; Opiate Substituti | 2023 |
Stimulant use among patients in opioid treatment settings: Provider perspectives.
Topics: Analgesics, Opioid; Drug Overdose; Fentanyl; Humans; Methadone; Opiate Substitution Treatment; Opioi | 2023 |
Safety of rapid inpatient methadone initiation protocol: A retrospective cohort study.
Topics: Adult; Aftercare; Analgesics, Opioid; Cohort Studies; Drug Overdose; Fentanyl; Humans; Inpatients; M | 2023 |
"Just fighting for my life to stay alive": a qualitative investigation of barriers and facilitators to community re-entry among people with opioid use disorder and incarceration histories.
Topics: Analgesics, Opioid; Drug Overdose; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related | 2023 |
Perceived access to opioid agonist treatment in prison among people with a history of injection drug use: A qualitative study.
Topics: Adolescent; Adult; Analgesics, Opioid; Drug Overdose; Humans; Male; Methadone; Prisons; Substance Ab | 2023 |
Drug use patterns and factors related to the use and discontinuation of medications for opioid use disorder in the age of fentanyl: findings from a mixed-methods study of people who use drugs.
Topics: Analgesics, Opioid; Benzodiazepines; Buprenorphine; Crack Cocaine; Drug Overdose; Fentanyl; Heroin; | 2023 |
Racial, Ethnic, and Sex Differences in Methadone-Involved Overdose Deaths Before and After the US Federal Policy Change Expanding Take-home Methadone Doses.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; COVID-19; Drug Overdose; Female; Humans; Ma | 2023 |
Increase in hospitalisation-associated methadone intoxication in France following first COVID-19 lockdown.
Topics: Adult; Communicable Disease Control; COVID-19; Drug Overdose; France; Hospitalization; Humans; Metha | 2023 |
Naloxone prescriptions among patients with a substance use disorder and a positive fentanyl urine drug screen presenting to the emergency department.
Topics: Analgesics, Opioid; Cocaine; Drug Overdose; Emergency Service, Hospital; Fentanyl; Humans; Illicit D | 2023 |
Large variations in all-cause and overdose mortality among >13,000 patients in and out of opioid maintenance treatment in different settings: a comparative registry linkage study.
Topics: Buprenorphine; Drug Overdose; Female; Humans; Male; Methadone; Opiate Substitution Treatment; Opioid | 2023 |
Dynamic changes in methadone utilisation for opioid use disorder treatment: a retrospective observational study during the COVID-19 pandemic.
Topics: Analgesics, Opioid; COVID-19; Drug Overdose; Humans; Methadone; Opiate Substitution Treatment; Opioi | 2023 |
US ED Opioid-Related Visits Increase, While Use of Medication for Opioid Use Disorder Undetectable, 2011-2016.
Topics: Buprenorphine; Drug Overdose; Emergency Service, Hospital; Humans; Methadone; Naltrexone; Narcotic A | 2020 |
Fentanyl exposure and preferences among individuals starting treatment for opioid use disorder.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Overdose; Female; Fentanyl; Heroin; Humans; Male; Met | 2019 |
Characteristics and Receipt of Medication Treatment Among Young Adults Who Experience a Nonfatal Opioid-Related Overdose.
Topics: Adolescent; Adult; Age Distribution; Analgesics, Opioid; Buprenorphine; Databases, Factual; Drug Ove | 2020 |
Characteristics and circumstances of heroin and pharmaceutical opioid overdose deaths: Comparison across opioids.
Topics: Adolescent; Adult; Analgesics, Opioid; Australia; Chronic Pain; Drug Overdose; Drug Prescriptions; F | 2019 |
Potential undercounting of overdose deaths caused by specific drugs in vital statistics data: An analysis of Florida.
Topics: Adult; Amphetamines; Analgesics, Opioid; Benzodiazepines; Cause of Death; Cocaine; Data Accuracy; Dr | 2020 |
Do interruptions to the continuity of methadone maintenance treatment in specialist addiction settings increase the risk of drug-related poisoning deaths? A retrospective cohort study.
Topics: Adult; Cause of Death; Cohort Studies; Drug Overdose; Female; Humans; Ireland; Male; Methadone; Midd | 2020 |
Opioid agonist treatment and fatal overdose risk in a state-wide US population receiving opioid use disorder services.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Cause of Death; Cohort Studies; Drug Overdose; | 2020 |
Association between mortality rates and medication and residential treatment after in-patient medically managed opioid withdrawal: a cohort analysis.
Topics: Adolescent; Adult; Buprenorphine; Cohort Studies; Drug Overdose; Female; Humans; Male; Massachusetts | 2020 |
Methadone poisonings: a seven-year retrospective study of the French poison center network focusing on suicide attempt vs. misuses.
Topics: Drug Overdose; Humans; Methadone; Poisons; Retrospective Studies; Suicide, Attempted | 2020 |
The psychiatrist at the centre of the opioid crisis.
Topics: Alcoholism; Cocaine-Related Disorders; Dopamine; Drug Overdose; Heroin Dependence; History, 20th Cen | 2020 |
Non-Opioid Substances Acute Poisonings with Suicidal Intent in Patients with Opioid Use Disorder.
Topics: Adolescent; Adult; Analgesics, Opioid; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; | 2020 |
Naloxone should remain the appropriate antidote to treat opioid overdose.
Topics: Analgesics, Opioid; Antidotes; Buprenorphine; Drug Overdose; Humans; Methadone; Naloxone; Prospectiv | 2020 |
Methadone-related deaths among youth and young adults in Sweden 2006-15.
Topics: Adolescent; Adult; Drug Overdose; Female; Humans; Male; Methadone; Narcotics; Opioid-Related Disorde | 2021 |
Clinical characteristics and time trends of hospitalized methadone exposures in the United States based on the Toxicology Investigators Consortium (ToxIC) case registry: 2010-2017.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Child; Child, Preschool; Coma; Drug Overdose; Female; H | 2020 |
Time-Dependent Changes in the Serum Levels of Neurobiochemical Factors After Acute Methadone Overdose in Adolescent Male Rat.
Topics: Age Factors; Analgesics, Opioid; Animals; Biomarkers; Brain; Drug Overdose; Inflammation Mediators; | 2021 |
Perspectives of clients and providers on factors influencing opioid agonist treatment uptake among HIV-positive people who use drugs in Indonesia, Ukraine, and Vietnam: HPTN 074 study.
Topics: Adult; Analgesics, Opioid; Anti-HIV Agents; Buprenorphine; Drug Overdose; Female; Health Services Ac | 2020 |
Revising our attitudes towards agonist medications and their diversion in a time of pandemic.
Topics: Analgesics, Opioid; Buprenorphine; Coronavirus Infections; COVID-19; Drug Overdose; Humans; Methadon | 2020 |
Acute right ventricular failure: a novel presentation of methadone-induced cardiotoxicity.
Topics: Acute Disease; Antitussive Agents; Cardiotoxicity; Drug Overdose; Female; Heart Failure; Humans; Met | 2020 |
Rapid transitional response to the COVID-19 pandemic by opioid agonist treatment programs in Ukraine.
Topics: Analgesics, Opioid; Buprenorphine; COVID-19; Drug Overdose; Humans; Methadone; Opiate Substitution T | 2021 |
Unprecedented need and recommendations for harnessing data to guide future policy and practice for opioid use disorder treatment following COVID-19.
Topics: Big Data; Buprenorphine; COVID-19; Drug Overdose; Health Policy; Humans; Methadone; Narcotic Antagon | 2021 |
Reimagining patient-centered care in opioid treatment programs: Lessons from the Bronx during COVID-19.
Topics: Appointments and Schedules; Buprenorphine; Clinical Decision-Making; COVID-19; Drug Overdose; Health | 2021 |
The Justice System and Young Adults With Substance Use Disorders.
Topics: Age Factors; Consensus Development Conferences as Topic; Criminal Law; Drug Overdose; Harm Reduction | 2021 |
Association of Opioid Use Disorder Treatment With Alcohol-Related Acute Events.
Topics: Accidental Falls; Adult; Alcohol-Related Disorders; Alcoholism; Analgesics, Opioid; Buprenorphine; C | 2021 |
Troponin, A Predictor of Mortality in Methadone Exposure: An Observational Prospective Study.
Topics: Adolescent; Adult; Aged; Biomarkers; Drug Overdose; Female; Follow-Up Studies; Hospital Mortality; H | 2021 |
Trends of acute drug and chemical toxicities in adults and adolescents in Tehran, Iran between 2012 and 2018: a retrospective chart review.
Topics: Adolescent; Adult; Drug Overdose; Humans; Iran; Methadone; Narcotics; Retrospective Studies | 2022 |
Changes in methadone program practices and fatal methadone overdose rates in Connecticut during COVID-19.
Topics: Analgesics, Opioid; Connecticut; COVID-19; Drug Overdose; Humans; Methadone; Opiate Substitution Tre | 2021 |
Post-incarceration outcomes for individuals who continued methadone treatment while in Connecticut jails, 2014-2018.
Topics: Analgesics, Opioid; Case-Control Studies; Connecticut; Drug Overdose; Humans; Jails; Male; Methadone | 2021 |
Benzodiazepine, z-drug and pregabalin prescriptions and mortality among patients in opioid maintenance treatment-A nation-wide register-based open cohort study.
Topics: Adolescent; Adult; Benzodiazepines; Buprenorphine; Drug Overdose; Drug Prescriptions; Female; Humans | 2017 |
Methadone Prescribing and Overdose and the Association with Medicaid Preferred Drug List Policies - United States, 2007-2014.
Topics: Databases, Factual; Drug Overdose; Drug Prescriptions; Health Policy; Humans; Medicaid; Methadone; P | 2017 |
Fatal and non-fatal opioid overdose in opioid dependent patients treated with methadone, buprenorphine or implant naltrexone.
Topics: Adult; Buprenorphine; Cohort Studies; Drug Implants; Drug Overdose; Female; Humans; Male; Methadone; | 2017 |
Zoning out methadone and rising opioid-related deaths in Ontario: Reforms and municipal government actions.
Topics: Analgesics, Opioid; Drug Overdose; Government Regulation; Health Care Reform; Humans; Local Governme | 2017 |
Suspected Methadone Toxicity: from Hospital to Autopsy Bed.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analgesics, Opioid; Autopsy; Blood Gas Anal | 2017 |
Risk factors for severe respiratory depression from prescription opioid overdose.
Topics: Adult; Age Factors; Analgesics, Opioid; Cohort Studies; Drug Overdose; Emergency Service, Hospital; | 2018 |
Commentary on Marsden et al. (2017): While epidemiological studies can help to identify areas of overdose risk, we need more focused hypothesis-driven trials to inform clinical intervention strategies.
Topics: Drug Overdose; England; Humans; Methadone; Opiate Substitution Treatment; Prisons; Prospective Studi | 2017 |
Increases from 2002 to 2015 in prescription opioid overdose deaths in combination with other substances.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Black or African American; Cocaine; Drug Overdose; Ethan | 2017 |
Rationale for cannabis-based interventions in the opioid overdose crisis.
Topics: Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Drug Overdose; Evidence-Based Medicine | 2017 |
Death From Opioid Overdose After Deep Brain Stimulation: A Case Report.
Topics: Adult; Analgesics, Opioid; Antisocial Personality Disorder; Clinical Trials as Topic; Combined Modal | 2018 |
Forensic Toxicology Perspectives of Methadone-associated Deaths in Tehran, Iran, a 7-year Overview.
Topics: Adult; Cause of Death; Controlled Substances; Cross-Sectional Studies; Drug Overdose; Female; Forens | 2018 |
Excess overdose mortality immediately following transfer of patients and their care as well as after cessation of opioid substitution therapy.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cause of Death; Drug Overdose; Female; Humans; Male; Metha | 2018 |
A cross-national analysis of the association between years of implementation of opioid substitution treatments and drug-related deaths in Europe from 1995 to 2013.
Topics: Analgesics, Opioid; Buprenorphine; Drug Overdose; Europe; Heroin Dependence; Humans; Methadone; Opia | 2018 |
Postincarceration Fatal Overdoses After Implementing Medications for Addiction Treatment in a Statewide Correctional System.
Topics: Adolescent; Adult; Buprenorphine; Cause of Death; Drug Overdose; Female; Fentanyl; Health Plan Imple | 2018 |
Observational study of dermatological manifestations in patients admitted to a tertiary poison center in Iran
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Drug Overdose; Female; Hospitalization; Humans; Hyperpig | 2018 |
Methadone Maintenance Treatment: A 15-year Retrospective Study in Split-Dalmatia County, Croatia.
Topics: Adolescent; Adult; Age Factors; Analgesics, Opioid; Croatia; Databases, Factual; Drug Overdose; Fema | 2018 |
The impact of buprenorphine and methadone on mortality: a primary care cohort study in the United Kingdom.
Topics: Adult; Buprenorphine; Cause of Death; Cohort Studies; Drug Overdose; Female; Humans; Male; Methadone | 2018 |
Medical, psychosocial, and treatment predictors of opioid overdose among high risk opioid users.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Overdose; Female; Friends; Hepatitis C, Chronic; Huma | 2018 |
Trends in engagement in the cascade of care for opioid use disorder, Vancouver, Canada, 2006-2016.
Topics: Adult; Analgesics, Opioid; British Columbia; Cohort Studies; Community Health Centers; Drug Overdose | 2018 |
Medicines for Patients After an Opioid Overdose.
Topics: Analgesics, Opioid; Buprenorphine; Drug Overdose; Humans; Methadone; Opiate Substitution Treatment; | 2018 |
Medication for Opioid Use Disorder After Nonfatal Opioid Overdose and Association With Mortality: A Cohort Study.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Drug Overdose; Female; Humans; Male; Massachus | 2018 |
Moving Addiction Care to the Mainstream - Improving the Quality of Buprenorphine Treatment.
Topics: Buprenorphine; Drug Approval; Drug Overdose; Humans; Methadone; Naltrexone; Narcotic Antagonists; Op | 2018 |
Fatal and Nonfatal Overdose Among Pregnant and Postpartum Women in Massachusetts.
Topics: Adult; Buprenorphine; Drug Overdose; Female; Humans; Massachusetts; Methadone; Opiate Substitution T | 2018 |
Reducing the opioid overdose death toll in North America.
Topics: Analgesics, Opioid; Canada; Criminals; Drug Overdose; Humans; Methadone; North America; Retrospectiv | 2018 |
Medications for Alcohol and Opioid Use Disorders and Risk of Suicidal Behavior, Accidental Overdoses, and Crime.
Topics: Acamprosate; Adult; Aged; Alcohol Deterrents; Alcoholism; Buprenorphine; Cohort Studies; Crime; Drug | 2018 |
Using routinely collected data to understand and predict adverse outcomes in opioid agonist treatment: Protocol for the Opioid Agonist Treatment Safety (OATS) Study.
Topics: Analgesics, Opioid; Buprenorphine; Drug Overdose; Emergency Service, Hospital; Hospitalization; Huma | 2018 |
Improving Rural Access to Opioid Treatment Programs.
Topics: Analgesics, Opioid; Buprenorphine; Drug Overdose; Health Services Accessibility; Health Services Nee | 2018 |
Methadone maintenance treatment among patients exposed to illicit fentanyl in Rhode Island: Safety, dose, retention, and relapse at 6 months.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Overdose; Female; Fentanyl; Humans | 2018 |
Utilization of opioid agonist therapy among incarcerated persons with opioid use disorder in Vancouver, Canada.
Topics: Adult; Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Canada; Case-Control Studies; D | 2018 |
Reversal of Pediatric Opioid Toxicity with Take-Home Naloxone: a Case Report.
Topics: Administration, Intranasal; Analgesics, Opioid; Drug Overdose; Female; Home Care Services; Humans; I | 2019 |
Overdose mortality rates in Croatia and factors associated with self-reported drug overdose among persons who inject drugs in three Croatian cities.
Topics: Adult; Buprenorphine; Croatia; Cross-Sectional Studies; Drug Overdose; Female; Harm Reduction; Human | 2019 |
Comparing Canadian and United States opioid agonist therapy policies.
Topics: Buprenorphine; Canada; Drug Overdose; Health Policy; Humans; Insurance Coverage; Methadone; Naloxone | 2019 |
Drug-induced prolonged corrected QT interval in patients with methadone and opium overdose.
Topics: Adult; Analgesics, Opioid; Cross-Sectional Studies; Drug Overdose; Female; Humans; Iran; Long QT Syn | 2019 |
Changing Trends in Opioid Overdose Deaths and Prescription Opioid Receipt Among Veterans.
Topics: Adult; Analgesics, Opioid; Drug Overdose; Female; Heroin; Humans; Male; Methadone; Middle Aged; Opio | 2019 |
[Improve the benefit/risk balance of methadone by respecting its pharmacological specificities].
Topics: Analgesics, Opioid; Drug Overdose; France; Humans; Methadone; Opiate Substitution Treatment; Opioid- | 2019 |
Legal and policy changes urgently needed to increase access to opioid agonist therapy in the United States.
Topics: Buprenorphine; Drug Overdose; Health Policy; Health Services Accessibility; Humans; Methadone; Opiat | 2019 |
Opioid agonist treatments and heroin overdose deaths in Baltimore, Maryland, 1995-2009.
Topics: Baltimore; Buprenorphine; Drug Overdose; Heroin Dependence; Humans; Linear Models; Longitudinal Stud | 2013 |
Schwartz et al. respond.
Topics: Buprenorphine; Drug Overdose; Heroin Dependence; Humans; Methadone; Opiate Substitution Treatment | 2013 |
Efforts to reduce overdose deaths.
Topics: Buprenorphine; Drug Overdose; Heroin Dependence; Humans; Methadone; Opiate Substitution Treatment | 2013 |
Potential P-glycoprotein pharmacokinetic interaction of telaprevir with morphine or methadone.
Topics: Analgesics, Opioid; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytoc | 2013 |
Evaluation of metabolite/drug ratios in blood and urine as a tool for confirmation of a reduced tolerance in methadone-related deaths in Denmark.
Topics: Adult; Aged; Cause of Death; Denmark; Drug Overdose; Female; Humans; Male; Methadone; Middle Aged; N | 2013 |
The lethal burden of drug overdose.
Topics: Cause of Death; Cost Control; Cross-Cultural Comparison; Drug Overdose; Heroin Dependence; Humans; I | 2013 |
Acute respiratory distress syndrome caused by methadone syrup.
Topics: Administration, Oral; Adult; Coma; Drug Compounding; Drug Overdose; Female; Humans; Male; Methadone; | 2013 |
Take-home naloxone kits preventing overdose deaths.
Topics: British Columbia; Drug Overdose; Female; Humans; Male; Methadone; Naloxone; Narcotic Antagonists; Na | 2014 |
[Factors associated with overdose-caused mortality of HIV-positive patients who were on methadone maintenance treatment program].
Topics: Adult; Case-Control Studies; Drug Overdose; Drug Users; HIV Seropositivity; Humans; Male; Methadone; | 2013 |
UK doctor is struck off after drug user dies from overmedication.
Topics: Drug Overdose; Humans; Malpractice; Methadone; Scotland | 2014 |
Methadone overdose and withdrawal in a tetraplegic patient: a case report.
Topics: Adult; Analgesics, Opioid; Drug Overdose; Female; Humans; Methadone; Pain; Quadriplegia; Spinal Cord | 2014 |
The correlation between prolonged corrected QT interval with the frequency of respiratory arrest, endotracheal intubation, and mortality in acute methadone overdose.
Topics: Adolescent; Adult; Aged; Cross-Sectional Studies; Drug Overdose; Electrocardiography; Female; Humans | 2014 |
Intravenous methadone application as a serious risk factor for an overdose death: methadone-related fatalities in Hamburg from 2007 to 2012.
Topics: Adult; Buprenorphine; Drug Overdose; Female; Forensic Toxicology; Germany; Humans; Lactose; Male; Me | 2014 |
Prevalence and factors associated with HIV infection among injection drug users at methadone clinics in Taipei, Taiwan.
Topics: Adolescent; Adult; Ambulatory Care Facilities; Drug Overdose; Drug Users; Female; HIV Infections; Ho | 2014 |
Letter to the editor in response to: The correlation between prolonged corrected QT interval with the frequency of respiratory arrest, endotracheal intubation, and mortality in acute methadone overdose.
Topics: Drug Overdose; Female; Humans; Intubation, Intratracheal; Long QT Syndrome; Male; Methadone; Respira | 2014 |
Acute adult and adolescent poisoning in Tehran, Iran; the epidemiologic trend between 2006 and 2011.
Topics: Adolescent; Adult; Anticonvulsants; Cross-Sectional Studies; Drug Overdose; Female; Humans; Hypnotic | 2014 |
Reply to the letter to the editor in response to: The correlation between prolonged corrected QT interval with the frequency of respiratory arrest, endotracheal intubation, and mortality in acute methadone overdose.
Topics: Drug Overdose; Female; Humans; Intubation, Intratracheal; Long QT Syndrome; Male; Methadone; Respira | 2014 |
Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011.
Topics: Adult; Age Distribution; Analgesics, Opioid; Benzodiazepines; Black or African American; Drug Overdo | 2014 |
Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011.
Topics: Adult; Age Distribution; Analgesics, Opioid; Benzodiazepines; Black or African American; Drug Overdo | 2014 |
Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011.
Topics: Adult; Age Distribution; Analgesics, Opioid; Benzodiazepines; Black or African American; Drug Overdo | 2014 |
Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011.
Topics: Adult; Age Distribution; Analgesics, Opioid; Benzodiazepines; Black or African American; Drug Overdo | 2014 |
Reversal of opioid overdose syndrome in morphine-dependent rats using buprenorphine.
Topics: Animals; Buprenorphine; Drug Overdose; Male; Methadone; Morphine Dependence; Naloxone; Narcotic Anta | 2015 |
Illicit use of opioid substitution drugs: prevalence, user characteristics, and the association with non-fatal overdoses.
Topics: Adult; Buprenorphine; Cross-Sectional Studies; Drug Overdose; Drug Users; Female; Heroin; Humans; Il | 2015 |
Methadone and prescription drug overdose.
Topics: Analgesics, Opioid; Chronic Pain; Drug Overdose; Drug Prescriptions; Formularies as Topic; Humans; M | 2014 |
Adolescents at risk: pain pills to heroin: part II.
Topics: Adolescent; Analgesics, Opioid; Drug Overdose; Drug Substitution; Heroin; Heroin Dependence; Humans; | 2015 |
Drug-related deaths between 2002 and 2013 with accent to methadone and benzodiazepines.
Topics: Adolescent; Adult; Benzodiazepines; Cross-Sectional Studies; Drug Overdose; Female; Forensic Toxicol | 2015 |
The relative risk of fatal poisoning by methadone or buprenorphine within the wider population of England and Wales.
Topics: Analgesics, Opioid; Buprenorphine; Databases, Factual; Drug Overdose; Drug Prescriptions; England; H | 2015 |
Accidental methadone intoxication masquerading as asthma exacerbation with respiratory arrest in a six-year-old boy.
Topics: Asthma; Bradycardia; Child; Diagnosis, Differential; Drug Overdose; Humans; Male; Methadone; Naloxon | 2015 |
Opioid Overdose Deaths in the City and County of San Francisco: Prevalence, Distribution, and Disparities.
Topics: Adolescent; Adult; Aged; Black or African American; Cocaine; Drug Overdose; Female; Health Status Di | 2015 |
Harm Reduction: Front Line Public Health.
Topics: Buprenorphine; Drug Overdose; Harm Reduction; Humans; Methadone; Naloxone; Narcotic Antagonists; Nar | 2015 |
Methadone overdose causing acute cerebellitis and multi-organ damage.
Topics: Adolescent; Cerebellar Diseases; Drug Overdose; Humans; Magnetic Resonance Imaging; Male; Methadone; | 2016 |
Risk Factors for Mortality and Endotracheal Intubation after Methadone Intoxication.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Drug Overdose; Emergency Service, Hospital; Female; Glas | 2016 |
Methadone-related deaths. A ten year overview.
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography, Liquid; Drug Overdose; Female; Forensic | 2015 |
Impact of treatment for opioid dependence on fatal drug-related poisoning: a national cohort study in England.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Cohort Studies; Combined Modality Therapy; Dru | 2016 |
Understanding Heroin Overdose: A Study of the Acute Respiratory Depressant Effects of Injected Pharmaceutical Heroin.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Capnography; Drug Overdose; Electromyography; Femal | 2015 |
Methadone related deaths compared to all prescription related deaths.
Topics: Adolescent; Adult; Aged; California; Databases, Factual; Drug and Narcotic Control; Drug Overdose; D | 2015 |
Risk factors for opioid overdose and awareness of overdose risk among veterans prescribed chronic opioids for addiction or pain.
Topics: Adult; Aged; Analgesics, Opioid; Behavior, Addictive; Buprenorphine; Chronic Pain; Drug Overdose; Fe | 2016 |
Response to Bird et al.: The importance of post-release engagement in treatment in estimating impacts on post-release deaths.
Topics: Animals; Birds; Drug Overdose; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Diso | 2016 |
Communicating risk in the context of methadone formulation changes: A qualitative study of overdose warning posters in Vancouver, Canada.
Topics: Adult; British Columbia; Chemistry, Pharmaceutical; Drug Overdose; Female; Health Communication; Hum | 2016 |
Differences in polysubstance use patterns and drug-related outcomes between people who inject drugs receiving and not receiving opioid substitution therapies.
Topics: Abscess; Adolescent; Adult; Alcoholism; Amphetamine-Related Disorders; Analgesics, Opioid; Australia | 2016 |
Removal of methadone by extended dialysis using a high cut-off dialyzer: implications for the treatment of overdose and for pain management in patients undergoing light chain removal.
Topics: Acute Kidney Injury; Adult; Analgesics, Opioid; Drug Overdose; Humans; Male; Methadone; Pain Managem | 2016 |
[Overdose of heroin and influencing factors in intravenous drug users in parts of Yunnan].
Topics: China; Drug Overdose; Drug Users; Heroin; Heroin Dependence; HIV Seropositivity; Humans; Logistic Mo | 2016 |
Methadone-Related Overdose Deaths in a Liberal Opioid Maintenance Treatment Programme.
Topics: Adult; Benzodiazepines; Denmark; Drug Overdose; Female; Humans; Male; Methadone; Middle Aged; Opiate | 2016 |
Prescription of Long-Acting Opioids and Mortality in Patients With Chronic Noncancer Pain.
Topics: Analgesics, Opioid; Anticonvulsants; Antidepressive Agents; Cardiovascular Diseases; Cause of Death; | 2016 |
Determinants of willingness to enroll in opioid agonist treatment among opioid dependent people who inject drugs in Ukraine.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cross-Sectional Studies; Drug Overdose; Female; Humans; Ma | 2016 |
The pharma-fever that almost got away.
Topics: Acetaminophen; Aged; Analgesics, Opioid; Antipyretics; Carcinoma, Non-Small-Cell Lung; Drug Overdose | 2016 |
Trends in Methadone Distribution for Pain Treatment, Methadone Diversion, and Overdose Deaths - United States, 2002-2014.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Black or African American; Drug Overdose; Female; Hispa | 2016 |
Will Adding Methadone to Controlled Substance Monitoring Programs Help Psychiatrists Prevent Prescription Drug Overdoses?
Topics: Drug Information Services; Drug Overdose; Humans; Male; Methadone; Middle Aged; Narcotics; Opiate Su | 2016 |
National Trends in Hospitalizations for Opioid Poisonings Among Children and Adolescents, 1997 to 2012.
Topics: Adolescent; Age Distribution; Analgesics, Opioid; Child; Child, Preschool; Cross-Sectional Studies; | 2016 |
National Trends in Hospitalizations for Opioid Poisonings Among Children and Adolescents, 1997 to 2012.
Topics: Adolescent; Age Distribution; Analgesics, Opioid; Child; Child, Preschool; Cross-Sectional Studies; | 2016 |
National Trends in Hospitalizations for Opioid Poisonings Among Children and Adolescents, 1997 to 2012.
Topics: Adolescent; Age Distribution; Analgesics, Opioid; Child; Child, Preschool; Cross-Sectional Studies; | 2016 |
National Trends in Hospitalizations for Opioid Poisonings Among Children and Adolescents, 1997 to 2012.
Topics: Adolescent; Age Distribution; Analgesics, Opioid; Child; Child, Preschool; Cross-Sectional Studies; | 2016 |
Methadone complications amongst opioid-dependent patients in Malaysia: A case series.
Topics: Adult; Child, Preschool; Drug Overdose; Edema; Female; Humans; Malaysia; Male; Methadone; Narcotics; | 2018 |
A case of massive methadone overdose presented with refractory hypoglycemia.
Topics: Analgesics, Opioid; Diagnosis, Differential; Drug Overdose; Female; Humans; Hypoglycemia; Methadone; | 2017 |
Tell-Tale SNPs: The Role of CYP2B6 in Methadone Fatalities.
Topics: Analgesics, Opioid; Cytochrome P-450 CYP2B6; Drug Overdose; Humans; Methadone; Opioid-Related Disord | 2017 |
Overdose Risk in Young Children of Women Prescribed Opioids.
Topics: Accidents, Home; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; | 2017 |
Intravenous Buprenorphine: A Substitute for Naloxone in Methadone-Overdosed Patients?
Topics: Administration, Intravenous; Buprenorphine; Drug Overdose; Humans; Male; Methadone; Naloxone; Narcot | 2017 |
Another Senseless Death - The Case for Supervised Injection Facilities.
Topics: Buprenorphine; Drug Overdose; Heroin Dependence; Humans; Methadone; Needle-Exchange Programs; Opiate | 2017 |
Body pushing, prescription drugs and hospital admission.
Topics: Adult; Benzodiazepines; Body Packing; Cannabinoids; Drug Overdose; Foreign Bodies; Hospitalization; | 2017 |
Poisoning necessitating pediatric ICU admissions: size of pupils does matter.
Topics: Central Nervous System Depressants; Child; Child, Preschool; Drug Overdose; Female; Humans; Infant; | 2008 |
Methadone-associated sudden cardiac death?
Topics: Adult; Analgesics, Opioid; Autopsy; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug O | 2008 |
Divided doses for methadone maintenance.
Topics: Cause of Death; Drug Administration Schedule; Drug Overdose; Humans; Methadone; Narcotics; Opioid-Re | 2008 |
The impact of benzodiazepine use on methadone maintenance treatment outcomes.
Topics: Adult; Alcoholism; Benzodiazepines; Cocaine-Related Disorders; Comorbidity; Depressive Disorder; Dia | 2008 |
Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report.
Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Diazepam; Doxepin; | 2009 |
[Deaths among drug addicts in Eastern Denmark 2005].
Topics: Adult; Cause of Death; Denmark; Drug Overdose; Female; Forensic Toxicology; Heroin Dependence; Human | 2008 |
Clinical and diagnostic features of delayed hypoxic leukoencephalopathy.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Brain; Cocaine; Cognition Disorders; Depressive Disorder | 2008 |
Patterns of major depression and drug-related problems amongst heroin users across 36 months.
Topics: Adolescent; Adult; Buprenorphine; Cohort Studies; Comorbidity; Crime; Depressive Disorder, Major; Dr | 2009 |
Sudden hearing loss after a methadone overdose.
Topics: Adult; Drug Overdose; Hearing Loss, Sudden; Humans; Male; Methadone; Narcotic Antagonists | 2009 |
Preventing death among the recently incarcerated: an argument for naloxone prescription before release.
Topics: Analgesics, Opioid; Cocaine; Drug Overdose; Emergency Medical Services; Female; Humans; Male; Methad | 2009 |
Prescription opioids and overdose deaths.
Topics: Analgesics, Opioid; Drug Overdose; Florida; Humans; Methadone; Population Surveillance; Prescription | 2009 |
Prescription opioids and overdose deaths.
Topics: Analgesics, Opioid; Drug Labeling; Drug Overdose; Humans; Methadone; West Virginia | 2009 |
Comparing overdose mortality associated with methadone and buprenorphine treatment.
Topics: Adult; Buprenorphine; Databases, Factual; Drug Overdose; Female; Humans; Male; Methadone; Middle Age | 2009 |
A case of serotonin syndrome associated with methadone overdose.
Topics: Adult; Cyclohexanols; Drug Overdose; Humans; Male; Methadone; Selective Serotonin Reuptake Inhibitor | 2008 |
Mortality among clients of a state-wide opioid pharmacotherapy program over 20 years: risk factors and lives saved.
Topics: Adult; Buprenorphine; Cause of Death; Data Interpretation, Statistical; Databases, Factual; Drug Ove | 2009 |
A comparison of drug overdose deaths involving methadone and other opioid analgesics in West Virginia.
Topics: Adolescent; Adult; Analgesics, Opioid; Cause of Death; Drug Overdose; Drug Prescriptions; Female; Fo | 2009 |
The comparative toxicology and major organ pathology of fatal methadone and heroin toxicity cases.
Topics: Adult; Analgesics, Opioid; Autopsy; Benzodiazepines; Central Nervous System Depressants; Drug Overdo | 2010 |
[Overdose statistics--a complicated account].
Topics: Cause of Death; Central Nervous System Stimulants; Drug Overdose; Forensic Toxicology; Heroin Depend | 2009 |
Mechanisms of respiratory insufficiency induced by methadone overdose in rats.
Topics: Acidosis, Respiratory; Animals; Dose-Response Relationship, Drug; Drug Overdose; Exhalation; Hypoxia | 2010 |
Interpretation of hair findings in children after methadone poisoning.
Topics: Child, Preschool; Chromatography, Liquid; Drug Overdose; Forensic Toxicology; Hair; Humans; Infant; | 2010 |
Contributing factors to methadone-related deaths in Ontario.
Topics: Accidents, Traffic; Adult; Age Distribution; Cannabinoids; Central Nervous System Depressants; Drug | 2010 |
A reduction in blood morphine concentrations amongst heroin overdose fatalities associated with a sustained reduction in street heroin purity.
Topics: Adult; Australia; Benzodiazepines; Central Nervous System Depressants; Drug Contamination; Drug Over | 2010 |
Prospective comparative assessment of buprenorphine overdose with heroin and methadone: clinical characteristics and response to antidotal treatment.
Topics: Adult; Antidotes; Buprenorphine; Drug Overdose; Female; Flumazenil; Heroin; Heroin Dependence; Human | 2010 |
Comparative toxicology of intentional and accidental heroin overdose.
Topics: Accidents; Adult; Body Mass Index; Central Nervous System Depressants; Cocaine; Drug Overdose; Ethan | 2010 |
Methadone-induced rigid-chest syndrome after substantial overdose.
Topics: Drug Administration Schedule; Drug Overdose; Fentanyl; Follow-Up Studies; Humans; Infant, Newborn; I | 2010 |
Were the changes to Sweden's maintenance treatment policy 2000-06 related to changes in opiate-related mortality and morbidity?
Topics: Adult; Buprenorphine; Clinical Protocols; Drug Overdose; Female; Hospitalization; Humans; Male; Meth | 2010 |
Medical treatment of opioid dependence within the South African context.
Topics: Buprenorphine; Drug Combinations; Drug Overdose; Humans; Methadone; Motivation; Naloxone; Narcotic A | 2010 |
Delayed akinetic catatonic mutism following methadone overdose.
Topics: Akinetic Mutism; Catatonia; Drug Overdose; Female; Humans; Leukoencephalopathies; Methadone; Time Fa | 2010 |
Impact of supervision of methadone consumption on deaths related to methadone overdose (1993-2008): analyses using OD4 index in England and Scotland.
Topics: Adult; Directly Observed Therapy; Drug Overdose; England; Humans; Methadone; Mortality; Narcotics; O | 2010 |
Drug-related deaths with evidence of intracorporeal drug concealment at autopsy: five case reports.
Topics: Adult; Anal Canal; Benzodiazepines; Cocaine; Crime; Drug Overdose; Forensic Pathology; Forensic Toxi | 2011 |
The methadone epidemic: methadone-related deaths on the rise in Vermont.
Topics: Accidents; Adolescent; Adult; Age Distribution; Aged; Central Nervous System Depressants; Crime; Dru | 2011 |
Epidemiologic trends and geographic patterns of fatal opioid intoxications in Connecticut, USA: 1997-2007.
Topics: Adolescent; Adult; Analgesics, Opioid; Cause of Death; Connecticut; Drug Overdose; Female; Heroin; H | 2011 |
Methadone, another cause of opioid-associated hearing loss: a case report.
Topics: Drug Overdose; Hearing Loss, Sensorineural; Hearing Loss, Sudden; Humans; Male; Methadone; Narcotics | 2011 |
Predictors of methadone treatment retention from a multi-site study: a survival analysis.
Topics: Adult; Baltimore; Crime; Dose-Response Relationship, Drug; Drug Overdose; Female; Humans; Male; Meth | 2011 |
A qualitative study exploring the reason for low dosage of methadone prescribed in the MMT clinics in China.
Topics: Adult; Ambulatory Care Facilities; China; Drug Overdose; Female; Health Communication; Heroin Depend | 2011 |
Accidental death from take home methadone maintenance doses: A report of a case and suggestions for prevention.
Topics: Accidents; Analgesics, Opioid; Child, Preschool; Drug Overdose; Fatal Outcome; Humans; Male; Methado | 2011 |
Painkillers fuel growth in drug addiction. Opioid overdoses now kill more people than cocaine or heroin.
Topics: Analgesics, Opioid; Buprenorphine; Cocaine; Drug Overdose; Drug Prescriptions; Health Knowledge, Att | 2011 |
An analysis of the root causes for opioid-related overdose deaths in the United States.
Topics: Analgesics, Opioid; Comorbidity; Databases, Factual; Drug Overdose; Humans; Medication Errors; Metha | 2011 |
Project Lazarus: community-based overdose prevention in rural North Carolina.
Topics: Analgesics, Opioid; Drug Overdose; Humans; Methadone; Naloxone; Narcotic Antagonists; North Carolina | 2011 |
Drug overdose deaths--Florida, 2003-2009.
Topics: Alprazolam; Cause of Death; Cocaine; Drug Overdose; Florida; Humans; Illicit Drugs; Methadone; Morph | 2011 |
The source of methadone in overdose deaths in Western Virginia in 2004.
Topics: Adult; Cause of Death; Coroners and Medical Examiners; Drug Overdose; Drug Prescriptions; Female; Hu | 2011 |
A procedure that differentiates unintentional from intentional overdose in opioid abusers.
Topics: Adult; Analgesics, Opioid; Drug Overdose; Female; Follow-Up Studies; Hospitals, University; Humans; | 2012 |
Takotsubo cardiomyopathy due to iatrogenic methadone withdrawal.
Topics: Analgesics, Opioid; Coronary Angiography; Drug Overdose; Echocardiography; Electrocardiography; Huma | 2011 |
Imaging of subacute blood-brain barrier disruption after methadone overdose.
Topics: Adult; Blood-Brain Barrier; Cerebrovascular Disorders; Drug Overdose; Humans; Magnetic Resonance Ang | 2013 |
Delayed leukoencephalopathy after alprazolam and methadone overdose: a case report and review of the literature.
Topics: Adult; Alprazolam; Analgesics, Opioid; Behavior; Brain; Drug Overdose; Female; Glasgow Coma Scale; H | 2012 |
Vital signs: risk for overdose from methadone used for pain relief - United States, 1999-2010.
Topics: Analgesics, Opioid; Drug Overdose; Guideline Adherence; Humans; Methadone; Pain; Practice Patterns, | 2012 |
Using poison center exposure calls to predict methadone poisoning deaths.
Topics: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Child; Child, Preschool; Drug Overdose | 2012 |
Comparison of fatal poisonings by prescription opioids.
Topics: Accidents; Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Central Nervous System Depressants; | 2012 |
Methadone toxicity and possible induction and enhanced elimination in a premature neonate.
Topics: Cytochrome P-450 CYP3A; Drug Overdose; Humans; Infant, Newborn; Intensive Care Units; Male; Methadon | 2012 |
Methadone overdose deaths rise with increased prescribing for pain.
Topics: Analgesics, Opioid; Drug Costs; Drug Overdose; Formularies as Topic; Humans; Medicaid; Methadone; Mo | 2012 |
Early antidote use associated with noninvasive ventilation in prehospital treatment of methadone intoxication.
Topics: Analgesics, Opioid; Combined Modality Therapy; Drug Overdose; Emergency Medical Services; Humans; Ma | 2013 |
Opioid overdose prevention with intranasal naloxone among people who take methadone.
Topics: Administration, Intranasal; Adult; Drug Overdose; Female; HIV Infections; Humans; Male; Massachusett | 2013 |
The pathogenetic role of adulterants in 5 cases of drug addicts with a fatal outcome.
Topics: Adult; Anesthetics, Local; Antitussive Agents; Bile; Brain Chemistry; Caffeine; Central Nervous Syst | 2013 |
Factors associated with mortality among heroin users after seeking treatment with methadone: a population-based cohort study in Taiwan.
Topics: Accidents; Adult; Age Factors; Cohort Studies; Drug Overdose; Heroin Dependence; Humans; Methadone; | 2013 |
Prescription opioid mortality trends in New York City, 1990-2006: examining the emergence of an epidemic.
Topics: Adolescent; Adult; Age Factors; Analgesics, Opioid; Data Interpretation, Statistical; Drug Overdose; | 2013 |
An increase in overdose mortality during the first 2 weeks after entering or re-entering methadone treatment in Amsterdam.
Topics: Adult; Cohort Studies; Drug Overdose; Female; Heroin; Heroin Dependence; Humans; Male; Methadone; Na | 2002 |
A review of methadone deaths in Jefferson County, Alabama.
Topics: Adolescent; Adult; Aged; Alabama; Benzodiazepines; Cause of Death; Drug Combinations; Drug Interacti | 2002 |
A cluster of nine overdoses (one fatal) related to methadone in the north of France: a lesson for drug policy in frontier regions.
Topics: Drug Overdose; France; Humans; Methadone; Narcotics | 2002 |
Methadone maintenance treatment, criminality and overdose-related deaths. An ecological study, 1983-1999.
Topics: Crime; Drug Overdose; Heroin; Humans; Methadone; Opioid-Related Disorders; Prevalence; Switzerland | 2002 |
Office-based treatment of opioid-dependent patients.
Topics: Buprenorphine; Drug and Narcotic Control; Drug Combinations; Drug Overdose; Family Practice; Humans; | 2003 |
Methadone dose and post-mortem blood concentration.
Topics: Drug Overdose; Female; Humans; Male; Methadone; Postmortem Changes; Substance-Related Disorders | 2002 |
Methadone induced mortality as a function of the circadian cycle.
Topics: Animals; Circadian Rhythm; Darkness; Drug Overdose; Heroin Dependence; Lethal Dose 50; Light; Methad | 1972 |
Methadone-related and heroin-related deaths among opiate users: methadone helps save lives.
Topics: Drug Overdose; Heroin Dependence; Humans; Methadone; Narcotics; United Kingdom | 2003 |
Prevalence and correlates of intravenous methadone syrup administration in Adelaide, Australia.
Topics: Adolescent; Adult; Comorbidity; Cross-Sectional Studies; Drug Overdose; Female; Heroin; Heroin Depen | 2003 |
Trends in drug overdose deaths in England and Wales 1993-98: methadone does not kill more people than heroin.
Topics: Adolescent; Adult; Drug Overdose; England; Female; Heroin Dependence; Humans; Male; Methadone; Middl | 2003 |
Methadone overdoses increase at alarming rate.
Topics: Analgesics, Opioid; Drug Overdose; Florida; Humans; Methadone; Substance-Related Disorders | 2003 |
Methadone and its role in drug-related fatalities in Cologne 1989-2000.
Topics: Benzodiazepines; Cause of Death; Drug Overdose; Ethanol; Female; Germany; Heroin; Humans; Illicit Dr | 2003 |
Methadone-related deaths in Hennepin County, Minnesota: 1992-2002.
Topics: Adult; Aged; Aged, 80 and over; Cause of Death; Drug Overdose; Female; Forensic Medicine; Gas Chroma | 2003 |
The role of methadone in drug-related deaths in the west of Scotland.
Topics: Adolescent; Adult; Drug Overdose; Heroin Dependence; Humans; Incidence; Methadone; Middle Aged; Narc | 2003 |
Increase in deaths due to methadone in North Carolina.
Topics: Adult; Cause of Death; Drug Overdose; Female; Humans; Male; Methadone; Mortality; Narcotics; North C | 2003 |
Loss of tolerance and overdose mortality with detoxification: abstinence is a valid choice.
Topics: Drug Overdose; Drug Tolerance; Methadone; Narcotics; Opioid-Related Disorders | 2003 |
Sudden death in an adult taking methadone: lessons for general practice.
Topics: Adult; Benzodiazepines; Death, Sudden; Drug Overdose; Drug Synergism; Family Practice; Fatal Outcome | 2003 |
Accidental methadone overdose in an opiate-naive elderly patient.
Topics: Aged; Coma; Critical Care; Drug Overdose; Female; Humans; Medication Errors; Methadone; Narcotics; P | 2003 |
[Two observations of respiratory paralysis after overdose of polamidone].
Topics: Drug Overdose; Humans; Methadone; Muscles; Paralysis; Respiratory Paralysis; Thorax | 1953 |
[Overdose of methadon causing death in infant].
Topics: Cause of Death; Drug Overdose; Humans; Hypnotics and Sedatives; Infant; Methadone; Poisoning; Respir | 1954 |
Relationship between prescribing and risk of opiate overdose among drug users in and out of maintenance treatment.
Topics: Adult; Alcoholic Intoxication; Benzodiazepines; Causality; Cocaine-Related Disorders; Comorbidity; C | 2004 |
Attempted suicide among entrants to three treatment modalities for heroin dependence in the Australian Treatment Outcome Study (ATOS): prevalence and risk factors.
Topics: Adolescent; Adult; Age Factors; Ambulatory Care; Antisocial Personality Disorder; Borderline Persona | 2004 |
Serious adverse events in the Australian National Evaluation of Pharmacotherapies for Opioid Dependence (NEPOD).
Topics: Adult; Analgesics, Opioid; Australia; Buprenorphine; Drug Overdose; Female; Humans; Male; Methadone; | 2004 |
Overdose deaths attributed to methadone and heroin in New York City, 1990-1998.
Topics: Adolescent; Adult; Cause of Death; Drug Overdose; Female; Heroin; Humans; Logistic Models; Male; Met | 2004 |
French field experience with buprenorphine.
Topics: Adult; Buprenorphine; Cause of Death; Cross-Cultural Comparison; Drug Approval; Drug Overdose; Drug | 2004 |
A critical review of the causes of death among post-mortem toxicological investigations: analysis of 34 buprenorphine-associated and 35 methadone-associated deaths.
Topics: Adult; Autopsy; Buprenorphine; Cause of Death; Drug Overdose; Female; Humans; Male; Methadone; Middl | 2004 |
Non-injecting routes of administration among entrants to three treatment modalities for heroin dependence.
Topics: Administration, Inhalation; Adolescent; Adult; Antisocial Personality Disorder; Borderline Personali | 2004 |
[The profile of drug addicts attending the Sainte Marguerite University Hospital in Marseille analysis of the active file from 1996 to 2001].
Topics: Adult; Age Distribution; Buprenorphine; Cohort Studies; Drug Overdose; Female; France; Hallucinogens | 2004 |
Increase in poisoning deaths caused by non-illicit drugs--Utah, 1991-2003.
Topics: Adult; Aged; Antidepressive Agents; Drug Overdose; Female; Humans; Male; Methadone; Middle Aged; Nar | 2005 |
Unintentional methadone-related overdose death in New Mexico (USA) and implications for surveillance, 1998-2002.
Topics: Adolescent; Adult; Aged; Cause of Death; Drug Overdose; Female; Humans; Male; Methadone; Narcotics; | 2005 |
Tighten Ontario's methadone program states inquest.
Topics: Adolescent; Adult; Drug Overdose; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Ontario; | 2005 |
Methadone overdose.
Topics: Adult; Drug Overdose; Emergency Nursing; Emergency Treatment; Humans; Male; Methadone; Nurse's Role; | 2004 |
Evaluating the impact of methadone maintenance programmes on mortality due to overdose and aids in a cohort of heroin users in Spain.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Drug Overdose; Female; Follow-Up Studies; Her | 2005 |
Factors associated with methadone maintenance therapy use among a cohort of polysubstance using injection drug users in Vancouver.
Topics: Adult; Canada; Catchment Area, Health; Cocaine-Related Disorders; Cohort Studies; Drug Overdose; Fac | 2005 |
Diabetic ketoacidosis--a possible complicating factor in deaths associated with drug overdose: two case reports.
Topics: Adult; Australia; Autopsy; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Drug Interactions; Drug | 2006 |
An overview of illegal opioid use and health services utilization in Canada.
Topics: Adolescent; Adult; Canada; Drug Overdose; Female; Health Services; Health Services Research; Humans; | 2006 |
Testing positive for methadone and either a tricyclic antidepressant or a benzodiazepine is associated with an accidental overdose death: analysis of medical examiner data.
Topics: Accidents; Adult; Antidepressive Agents, Tricyclic; Benzodiazepines; Cause of Death; Comorbidity; Co | 2006 |
Fatal poisoning in methadone and buprenorphine treated patients -- are there differences?
Topics: Adult; Buprenorphine; Cause of Death; Drug Evaluation, Preclinical; Drug Interactions; Drug Overdose | 2006 |
Cause and motivation in cases of non-fatal drug overdoses in opiate addicts.
Topics: Adult; Drug Overdose; Female; Humans; Male; Methadone; Motivation; Narcotics; Opioid-Related Disorde | 2006 |
Stay tuned and find out.
Topics: Drug Administration Schedule; Drug Overdose; Heroin Dependence; Humans; Methadone; Narcotics; Televi | 2006 |
Predictors of non-fatal overdose among a cohort of polysubstance-using injection drug users.
Topics: Adolescent; Child; Cocaine; Cohort Studies; Drug Overdose; Female; Follow-Up Studies; Heroin; Humans | 2007 |
Emergency naloxone for heroin overdose: naloxone is not the only opioid antagonist.
Topics: Drug Overdose; Emergencies; Emergency Treatment; Heroin; Humans; Methadone; Naloxone; Narcotic Antag | 2006 |
Changes to the daily pattern of methadone-related deaths in England and Wales, 1993-2003.
Topics: Death Certificates; Drug Overdose; England; Heroin; Holidays; Humans; Methadone; Morphine; Narcotics | 2006 |
Onset of symptoms after methadone overdose.
Topics: Adolescent; Adult; Drug Overdose; Humans; Medical Records; Methadone; Middle Aged; Naloxone; Narcoti | 2007 |
Surveillance of methadone-related adverse drug events using multiple public health data sources.
Topics: Adverse Drug Reaction Reporting Systems; Death Certificates; Drug Overdose; Drug Prescriptions; Huma | 2007 |
Fatal overdoses and deaths by other causes in a cohort of Norwegian drug abusers--a competing risk approach.
Topics: Adult; Age Factors; Amphetamine-Related Disorders; Buprenorphine; Cause of Death; Cohort Studies; Co | 2007 |
[Responsibility of physicians wrongly described].
Topics: Drug Overdose; Drug Prescriptions; Humans; Methadone; Narcotics; Physicians; Prisons | 2007 |
Obtundation in a toddler: naloxone is fundamental.
Topics: Child, Preschool; Drug Overdose; Emergency Medicine; Female; Humans; Methadone; Naloxone; Narcotic A | 2007 |
Drug intoxication deaths involving methadone, 2004-2005.
Topics: Analgesics, Opioid; Coroners and Medical Examiners; Drug Overdose; Forensic Medicine; Humans; Methad | 2007 |
Nonfatal overdose among heroin users in southwestern China.
Topics: Adult; Cause of Death; China; Drug Overdose; Female; Heroin; Heroin Dependence; Humans; Logistic Mod | 2007 |
Acute respiratory distress syndrome induced by oral methadone managed with non-invasive ventilation.
Topics: Administration, Oral; Continuous Positive Airway Pressure; Drug Overdose; Humans; Male; Methadone; M | 2007 |
Death, narcotic overdose, and serious cardiac arrhythmias: information for healthcare professionals on methadone.
Topics: Arrhythmias, Cardiac; Drug Overdose; Humans; Methadone; Patient Education as Topic; United States; U | 2007 |
The authors respond: Methadone overdose.
Topics: Drug Overdose; Emergency Medical Services; Humans; Methadone; Monitoring, Physiologic; Narcotics; Ti | 2007 |
Mortality in heroin users 3 years after naltrexone implant or methadone maintenance treatment.
Topics: Adult; Cohort Studies; Databases, Factual; Drug Implants; Drug Overdose; Female; Heroin Dependence; | 2008 |
Case files of the Drexel University Medical Toxicology Fellowship: methadone-induced QTc prolongation.
Topics: Adult; Drug Overdose; Electrocardiography; Emergency Medical Services; Humans; Long QT Syndrome; Mal | 2007 |
Mortality prior to, during and after opioid maintenance treatment (OMT): a national prospective cross-registry study.
Topics: Adult; Buprenorphine; Cross-Sectional Studies; Drug Overdose; Female; Follow-Up Studies; Humans; Mal | 2008 |
A community-based evaluation of sudden death associated with therapeutic levels of methadone.
Topics: Adult; Analgesics, Opioid; Autopsy; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug O | 2008 |
Somatic health among heroin addicts before and during opioid maintenance treatment: a retrospective cohort study.
Topics: Acute Disease; Adult; Ambulatory Care; Chronic Disease; Cohort Studies; Drug Overdose; Female; Healt | 2008 |
Onset of symptoms after methadone overdose.
Topics: Drug Overdose; Humans; Methadone; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorder | 2008 |
Methadone- and buprenorphine-related ambulance attendances: a population-based indicator of adverse events.
Topics: Adult; Ambulances; Buprenorphine; Databases, Factual; Drug Overdose; Emergency Medical Services; Fem | 2008 |
Estimating the total mortality among problem drug users.
Topics: Accidents; Adolescent; Adult; Age Factors; Cause of Death; Cohort Studies; Comorbidity; Data Collect | 2008 |
Bi-ventricular failure following methadone overdose.
Topics: Adult; Drug Overdose; Humans; Male; Methadone; Narcotics; Opioid-Related Disorders; Ventricular Dysf | 2008 |
Methadone- and heroin-related deaths in Florida.
Topics: Analgesics, Opioid; Cause of Death; Coroners and Medical Examiners; Databases, Factual; Drug Overdos | 2008 |
[Attempted suicide with a coumarin derivative].
Topics: Adult; Coumarins; Depressive Disorder; Drug Overdose; Heroin Dependence; Humans; Male; Methadone; Pr | 1995 |
Mortality among HIV-infected intravenous drug addicts in Stockholm in relation to methadone treatment.
Topics: Adult; Cause of Death; Cross-Cultural Comparison; Drug Overdose; Female; HIV Infections; Humans; Mal | 1995 |
Pertinent medical intelligence: methadone ingestion in children.
Topics: Child, Preschool; Drug Overdose; Emergencies; Epilepsy, Generalized; Heart Arrest; Humans; Infant; M | 1995 |
Accidental ingestion of methadone by children in Merseyside.
Topics: Accidents; Child; Child, Preschool; Drug Overdose; Emergencies; England; Female; Humans; Infant; Mal | 1994 |
Drug-related deaths during the 1980s. A comparative study of drug addict deaths examined at the institutes of forensic medicine in Aarhus, Denmark and Oslo, Norway.
Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Benzodiazepines; Cause of Death; Cross-Cultural Comp | 1993 |
A 24-year follow-up of California narcotics addicts.
Topics: Adult; California; Cause of Death; Drug Overdose; Employment; Follow-Up Studies; Health Status; Huma | 1993 |
[Fatal poisonings among drug addicts in Funen and South Jutland during the period 1989-1991].
Topics: Adolescent; Adult; Cause of Death; Denmark; Drug Overdose; Female; Humans; Male; Methadone; Middle A | 1993 |
[Methadone and drug addicts].
Topics: Adolescent; Adult; Cause of Death; Denmark; Drug Overdose; Female; Humans; Male; Methadone; Middle A | 1993 |
[Current drug problems].
Topics: Cocaine; Drug Overdose; Heroin Dependence; Humans; Methadone; Substance-Related Disorders | 1993 |
[Epidemiology of drug addiction in The Netherlands].
Topics: Acquired Immunodeficiency Syndrome; Drug Overdose; Humans; Mental Disorders; Methadone; Netherlands; | 1995 |
Characteristics of fatal methadone overdose in Manchester, 1985-94.
Topics: Adolescent; Adult; Child; Child, Preschool; Death, Sudden; Drug Overdose; England; Female; Humans; M | 1996 |
Fatal methadone overdose.
Topics: Adult; Drug Overdose; Fatal Outcome; Humans; Male; Methadone; Naloxone | 1996 |
Deaths among drug abusers in south-east Scotland (1989-1994).
Topics: Adolescent; Adult; Cause of Death; Drug Overdose; Female; HIV Seropositivity; Humans; Male; Methadon | 1996 |
The effectiveness and safety of methadone maintenance.
Topics: Cause of Death; Drug Overdose; Heroin Dependence; Humans; Long-Term Care; Methadone; Narcotics; Risk | 1996 |
Fatal methadone overdose. Better understanding of body's handling of methadone is needed.
Topics: Drug Overdose; Humans; Liver; Male; Methadone | 1996 |
Fatal methadone overdose. Close observation in intensive care unit is required when naloxone infusion ends.
Topics: Critical Care; Drug Overdose; Humans; Male; Methadone; Naloxone; Narcotic Antagonists | 1996 |
Methadone treatment. Methadone concentrations taken as indicating deaths due to overdose need to be reviewed.
Topics: Cause of Death; Drug Overdose; Humans; Methadone; Reference Values | 1996 |
Detection of alprazolam in three cases of methadone/benzodiazepine overdose.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Benzodiazepines; Chromatography, High Pressure Liquid; Drug | 1997 |
The dangers of dextropropoxyphene.
Topics: Adult; Analgesics, Opioid; Combined Modality Therapy; Dextropropoxyphene; Drug Overdose; Female; Hum | 1996 |
Methadone-related overdose deaths in South Australia, 1984-1994. How safe is methadone prescribing?
Topics: Adult; Australia; Drug Overdose; Drug Prescriptions; Female; Humans; Male; Methadone; Poisoning; Pop | 1997 |
Fatal methadone overdose.
Topics: Drug Overdose; Humans; Methadone; Narcotics | 1997 |
Marked decrease of immunolabelled 68 kDa neurofilament (NF-L) proteins in brains of opiate addicts.
Topics: Adult; Blotting, Western; Cerebral Cortex; Drug Overdose; Female; Heroin; Humans; Male; Methadone; M | 1997 |
Fatal methadone overdose. Drug services in Manchester were unfairly accused.
Topics: Drug Overdose; England; Humans; Methadone; Narcotics; Substance-Related Disorders | 1997 |
Fatal methadone overdose. Sloppy prescribing cannot be totally blamed for deaths from methadone overdose.
Topics: Drug Overdose; Humans; Methadone; Narcotics; Practice Patterns, Physicians'; Substance-Related Disor | 1997 |
Fatal methadone and heroin overdoses: time trends in England and Wales.
Topics: Accidents; Drug Overdose; England; Female; Heroin; Humans; Male; Methadone; Narcotics; Regression An | 1997 |
Reduction in use of temazepam is factor in deaths related to overdose.
Topics: Drug Overdose; Humans; Methadone; Narcotics; Opioid-Related Disorders; Scotland; Temazepam | 1997 |
[Fatal cases of methadone].
Topics: Drug Overdose; Fatal Outcome; Forensic Medicine; Humans; Methadone; Substance-Related Disorders | 1998 |
One-year mortality rates following methadone treatment discharge.
Topics: Adult; Cause of Death; Drug Overdose; Female; Follow-Up Studies; Heroin; Heroin Dependence; Humans; | 1998 |
Accidental drug toxicity associated with methadone maintenance treatment.
Topics: Australia; Drug Overdose; Drug Tolerance; Humans; Methadone; Substance-Related Disorders | 1999 |
Mortality associated with New South Wales methadone programs in 1994: lives lost and saved.
Topics: Adult; Cause of Death; Cross-Sectional Studies; Drug Overdose; Heroin Dependence; Humans; Male; Meth | 1999 |
Pre-AIDS mortality and morbidity among injection drug users in Amsterdam and Baltimore: an ecological comparison.
Topics: Adult; Amphetamines; Baltimore; Cause of Death; Cocaine; Cohort Studies; Comorbidity; Cost Control; | 1999 |
Methadone overdose in an opiate-naïve patient.
Topics: Alcoholism; Drug Overdose; Humans; Male; Medication Errors; Methadone; Middle Aged | 1999 |
Methadone-related deaths in New Zealand.
Topics: Adult; Cause of Death; Drug Overdose; Female; Heroin Dependence; Humans; Male; Methadone; Middle Age | 1999 |
Mortality associated with New South Wales methadone programs.
Topics: Drug Overdose; Heroin Dependence; Humans; Methadone; New South Wales; Substance Abuse Treatment Cent | 1999 |
Trends in opiate-related deaths in the United Kingdom and Australia, 1985-1995.
Topics: Adolescent; Adult; Australia; Cause of Death; Cross-Cultural Comparison; Cross-Sectional Studies; Dr | 2000 |
Methadone, methadone treatment and non-fatal overdose.
Topics: Adult; Drug Overdose; Female; Humans; Interviews as Topic; Male; Methadone; Narcotics; Substance-Rel | 2000 |
Toxicology and pathology of deaths related to methadone: retrospective review.
Topics: Adult; Drug Overdose; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disord | 2000 |
Is methadone a miracle cure or an alternative evil?
Topics: Drug Overdose; Heroin Dependence; Humans; Methadone; Narcotics | 2000 |
More on opioid overdose.
Topics: Drug Overdose; Humans; Methadone; Narcotics | 1999 |
Immunohistochemical detection of methadone in the human brain.
Topics: Adult; Brain Chemistry; Case-Control Studies; Cause of Death; Drug Overdose; Enzyme-Linked Immunosor | 2000 |
Cognitive impairment among methadone maintenance patients.
Topics: Adult; Aged; Alcoholism; Case-Control Studies; Cognition Disorders; Craniocerebral Trauma; Drug Over | 2000 |
Experience of heroin overdose among drug users attending general practice.
Topics: Adult; Drug Overdose; Family Practice; Female; Heroin; Heroin Dependence; Humans; Male; Methadone; N | 2000 |
[Fatal intoxications among drug addicts in Denmark in 1997].
Topics: Adolescent; Adult; Analgesics, Opioid; Cause of Death; Denmark; Drug Overdose; Female; Forensic Medi | 2000 |
Deaths attributable to methadone vs buprenorphine in France.
Topics: Buprenorphine; Drug Overdose; France; Heroin Dependence; Humans; Methadone; Narcotics | 2001 |
Lethal methadone intoxications in Geneva, Switzerland, from 1994 to 1998.
Topics: Adolescent; Adult; Drug Overdose; Humans; Methadone; Middle Aged; Narcotics; Retrospective Studies; | 2000 |
Back-projection estimates of the number of dependent heroin users in Australia.
Topics: Adolescent; Adult; Australia; Disease Progression; Drug Overdose; Epidemiologic Studies; Female; Her | 2001 |
The impact of harm-reduction-based methadone treatment on mortality among heroin users.
Topics: Adult; Cause of Death; Drug Overdose; Heroin Dependence; Humans; Methadone; Multivariate Analysis; N | 2001 |
[Reduction in the number of lethal heroin overdoses in France since 1994. Focus on substitution treatments].
Topics: Acquired Immunodeficiency Syndrome; Attitude to Health; Buprenorphine; Drug Overdose; Drug Prescript | 2001 |
Drugs of abuse--an analysis based on cases from the Kraków Department of Clinical Toxicology of Jagiellonian University College of Medicine in 1997-2000.
Topics: Adhesives; Adolescent; Adult; Age Distribution; Comorbidity; Drug Overdose; Female; Humans; Illicit | 2001 |
The relationship between suicide and heroin overdose among methadone maintenance patients in Sydney, Australia.
Topics: Cross-Sectional Studies; Drug Overdose; Female; Heroin; Humans; Male; Methadone; Narcotics; New Sout | 2001 |
Impact of HIV infection on mortality in a cohort of injection drug users.
Topics: Adolescent; Adult; Age Factors; Aged; British Columbia; Cause of Death; Cocaine; Cohort Studies; Dru | 2001 |
Conservative management with naltrexone of an iatrogenic methadone overdose in an opiate-naive patient.
Topics: Alcoholism; Cocaine-Related Disorders; Diagnosis, Dual (Psychiatry); Drug Overdose; Humans; Male; Me | 2002 |
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Intravenous bolus or infusion of naloxone in opioid overdose.
Topics: Adult; Antidotes; Drug Overdose; Evidence-Based Medicine; Heroin Dependence; Humans; Infusions, Intr | 2002 |
TX: did death result from methadone overdose?: Court finds failure to prove proximate cause.
Topics: Analgesics, Opioid; Drug Overdose; Fatal Outcome; Female; Humans; Malpractice; Methadone; Opioid-Rel | 2001 |
Estimating the trend of the epidemic of drug use in Italy, 1985-89.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Delivery of Health Care; Drug Overdose; Femal | 1992 |
[Drug substitution and withdrawal in pregnancy. Indication, side effects, acute status, monitoring and results].
Topics: Contraindications; Counseling; Drug Overdose; Female; Heroin Dependence; Humans; Infant, Newborn; Me | 1991 |
Fatal poisoning with intravenously injected methadone and no fresh injection marks found.
Topics: Drug Overdose; Fistula; Forensic Medicine; Humans; Male; Methadone; Necrosis; Photomicrography; Skin | 1991 |
Fatal intoxications in the age group 15-34 years in Denmark in 1984 and 1985. A forensic study with special reference to drug addicts.
Topics: Adolescent; Adult; Analgesics, Opioid; Barbiturates; Cause of Death; Cross-Sectional Studies; Denmar | 1989 |