methadone has been researched along with Disease Models, Animal in 49 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Comprehensive cerebral metabolites involved in morphine dependence have not been well explored." | 3.78 | (1) H-nuclear magnetic resonance-based metabonomic analysis of brain in rhesus monkeys with morphine treatment and withdrawal intervention. ( Bu, Q; Cen, X; Deng, P; Deng, Y; Duan, J; Hu, C; Hu, Z; Li, Y; Shao, X; Yan, G; Zhao, J; Zhao, Y; Zhou, J; Zhu, R, 2012) |
| "Methadone is a long-acting opioid used in the treatment of various pain states and substitution therapy in heroin addiction." | 3.77 | Characterization of the antinociceptive effects of the individual isomers of methadone after acute and chronic administrations. ( Morgan, RW; Nicholson, KL, 2011) |
| " Chronic use of methadone, administered orally, can result in a steady state with respect to both drug levels and overall functioning." | 2.37 | Opioid interactions with alcohol. ( Kreek, MJ, 1984) |
| "Methadone-based treatment for pregnant women with opioid use disorder is quite prevalent in the clinical environment." | 1.91 | Perturbed neurochemical and microstructural organization in a mouse model of prenatal opioid exposure: A multi-modal magnetic resonance study. ( Atwood, BK; Grecco, GG; Shahid, SS; Wu, YC, 2023) |
| "Methadone maintenance treatment (MMT) is the most common treatment for opioid-dependent pregnant women worldwide." | 1.62 | Prenatal methadone exposure impairs adolescent cognition and GABAergic neurodevelopment in a novel rat model of maternal methadone treatment. ( Bird, KM; Lum, JS; Millard, SJ; Newell, KA; Pallimulla, S; Wilkie, J; Wright, IM, 2021) |
| "Methadone only treated rats had a mean paw withdrawal latency significantly lower than the corresponding values for saline on days 8, 9, 10, 11, 12, 14, and 17 (P<0." | 1.36 | Model of methadone-induced hyperalgesia in rats and effect of memantine. ( Hay, JL; Irvine, R; Kaboutari, J; Salem, A; White, JM, 2010) |
| "Methadone is an opioid agonist often given to manage acute and chronic pain." | 1.35 | Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion. ( Gross, ER; Gross, GJ; Hsu, AK, 2009) |
| "The degree of hyperalgesia was greater with l-methadone compared with d,l-methadone." | 1.34 | Characterization of the antinociceptive and pronociceptive effects of methadone in rats. ( Holtman, JR; Wala, EP, 2007) |
| "While the depth of methadone-induced respiratory depression did not depend on pup age, the control of breathing was different in 3-day-old pups, where inspiratory time increased fourfold; twice that of older pups." | 1.34 | Methadone-induced respiratory depression in the neonatal guinea pig. ( Abraham, SL; Nelson, CS; Nettleton, RT; Olsen, GD; Ransom, TA, 2007) |
| "Methadone is a widely used synthetic opioid which is administered as a racemic mixture of (R)-(--)- and (S)-(+)-enantiomers, with only (R)-(--)-methadone possessing mu opioid receptor agonist activity." | 1.32 | (S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone. ( Hutchinson, MR; Somogyi, AA, 2004) |
| "Methadone maintenance was associated with significant decrements in food intake in four of five monkeys." | 1.27 | Comparison of buprenorphine and methadone effects on opiate self-administration in primates. ( Bree, MP; Mello, NK; Mendelson, JH, 1983) |
| "Naloxone pretreatment on doses up to 20 mg/kg was not effective in antagonizing PCP-induced behavioral effects." | 1.26 | Phencyclidine-induced stereotype in rats: effects of methadone, apomorphine, and naloxone. ( Kogan, MJ; Mulè, SJ; Verebey, K, 1981) |
| "Xylazine was significantly more effective in obtunding deep pain (P less than 0." | 1.26 | Objective tests of analgesic drugs in ponies. ( Lumb, WV; Pippi, NL, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (30.61) | 18.7374 |
| 1990's | 2 (4.08) | 18.2507 |
| 2000's | 14 (28.57) | 29.6817 |
| 2010's | 13 (26.53) | 24.3611 |
| 2020's | 5 (10.20) | 2.80 |
| Authors | Studies |
|---|---|
| Grecco, GG | 2 |
| Shahid, SS | 2 |
| Atwood, BK | 2 |
| Wu, YC | 2 |
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 4 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
| He, C | 2 |
| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 5 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Zhang, X | 7 |
| Xu, N | 1 |
| Wang, R | 1 |
| Liu, S | 1 |
| He, H | 1 |
| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Zhang, C | 3 |
| Chen, L | 3 |
| Yang, X | 1 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
| Gao, K | 1 |
| Zager, RA | 1 |
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| Keyser, J | 1 |
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| Yao, L | 2 |
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| Gentile, GL | 1 |
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| Yoo, JS | 1 |
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| Lee, EJ | 1 |
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| Delorme, M | 1 |
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| Conkrite, KL | 1 |
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| Macha, SJ | 1 |
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| Gilson, E | 1 |
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| Starenki, D | 1 |
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| Shao, H | 1 |
| Gestwicki, JE | 1 |
| Tsai, S | 1 |
| Park, JI | 1 |
| Wang, Y | 7 |
| Zhao, R | 1 |
| Gu, Z | 1 |
| Dong, C | 2 |
| Guo, G | 1 |
| Li, L | 4 |
| Barrett, HE | 1 |
| Meester, EJ | 1 |
| van Gaalen, K | 1 |
| van der Heiden, K | 1 |
| Krenning, BJ | 1 |
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| Salinas, B | 1 |
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| Sanchez-González, J | 1 |
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| van Haard, PMM | 1 |
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| Lin, Z | 1 |
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| Yu, X | 2 |
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| Hayton, TW | 1 |
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| Duan, W | 1 |
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| Deng, L | 1 |
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| Nettleton, RT | 2 |
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| Turzyńska, D | 1 |
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| Morgan, RW | 1 |
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| Zhu, R | 1 |
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| Somogyi, AA | 1 |
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| Xu, XJ | 2 |
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| Lewanowitsch, T | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| IRB-HSR# 14145 R,S Methadone: Analgesia and Pharmacokinetics in Adolescents Undergoing Scoliosis Correction[NCT01205256] | Phase 3 | 11 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| Opioid-Induced Hyperalgesia in Prescription Opioid Abusers: Effects of Pregabalin[NCT01821430] | Phase 2 | 4 participants (Actual) | Interventional | 2013-03-31 | Terminated (stopped due to poor recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for methadone and Disease Models, Animal
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Non-Opioid Treatments for Opioid Use Disorder: Rationales and Data to Date.
Topics: Analgesics, Opioid; Animals; Behavior, Addictive; Brain; Buprenorphine; Disease Models, Animal; Endo | 2020 |
Opioid interactions with alcohol.
Topics: Alcohol Oxidoreductases; Alcoholism; Animals; Disease Models, Animal; Drug Interactions; Estradiol; | 1984 |
Methadone during pregnancy: the search for a valid animal model.
Topics: Animals; Behavior, Animal; Child; Child, Preschool; Disease Models, Animal; Female; Heroin Dependenc | 1993 |
Conceptual issues in the use of drugs for the treatment of aggression in man.
Topics: Adolescent; Adult; Aggression; Alcoholic Intoxication; Animals; Anti-Anxiety Agents; Anticonvulsants | 1975 |
Drugs and chemicals associated with intrauterine growth deficiency.
Topics: Abnormalities, Drug-Induced; Adult; Aminopterin; Animals; Disease Models, Animal; Ethanol; Female; F | 1978 |
New pharmacotherapies for cocaine dependence ... revisited.
Topics: Alcoholism; Cocaine; Desipramine; Disease Models, Animal; Double-Blind Method; Heroin Dependence; Hu | 1992 |
2 trials available for methadone and Disease Models, Animal
41 other studies available for methadone and Disease Models, Animal
| Article | Year |
|---|---|
Alterations of brain microstructures in a mouse model of prenatal opioid exposure detected by diffusion MRI.
Topics: Analgesics, Opioid; Animals; Brain; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; | 2022 |
Perturbed neurochemical and microstructural organization in a mouse model of prenatal opioid exposure: A multi-modal magnetic resonance study.
Topics: Analgesics, Opioid; Animals; Brain; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; | 2023 |
Prenatal methadone exposure impairs adolescent cognition and GABAergic neurodevelopment in a novel rat model of maternal methadone treatment.
Topics: Analgesics, Opioid; Animals; Brain; Brain-Derived Neurotrophic Factor; Cognition; Disease Models, An | 2021 |
Sex Differences in Regional Brain Glucose Metabolism Following Opioid Withdrawal and Replacement.
Topics: Analgesics, Opioid; Animals; Brain; Brain Mapping; Buprenorphine; Cross-Sectional Studies; Disease M | 2017 |
Can we use an innocuous stimulus to replace methadone maintenance therapy for opioid dependence?
Topics: Animals; Conditioning, Classical; Disease Models, Animal; Electroacupuncture; Humans; Immune System; | 2010 |
S-Methadone augments R-methadone induced respiratory depression in the neonatal guinea pig.
Topics: Age Factors; Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Disease Models, An | 2009 |
Model of methadone-induced hyperalgesia in rats and effect of memantine.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Hyperalgesia; Male; Memantine; Methadone; Rats; R | 2010 |
Acute methadone treatment reduces myocardial infarct size via the delta-opioid receptor in rats during reperfusion.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administ | 2009 |
Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine.
Topics: Analgesics; Animals; Buprenorphine; Disease Models, Animal; Drug Tolerance; Female; Heroin Dependenc | 2010 |
Is slow-onset long-acting monoamine transport blockade to cocaine as methadone is to heroin? Implication for anti-addiction medications.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Delayed-Action Preparations; Disease Models, Ani | 2010 |
Diverse behavioral, monoaminergic and Fos protein responses to opioids in Warsaw high-alcohol preferring and Warsaw low-alcohol preferring rats.
Topics: Alcohol Drinking; Analgesics, Opioid; Animals; Behavior, Animal; Biogenic Monoamines; Brain; Disease | 2011 |
THC-methadone and THC-naltrexone interactions on discrimination, antinociception, and locomotion in rats.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Discrimination Learning; Disease Models, Anim | 2011 |
Treatment-like steady-state methadone in rats interferes with incubation of cocaine sensitization and associated alterations in gene expression.
Topics: Analgesics, Opioid; Animals; Brain; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopa | 2012 |
Characterization of the antinociceptive effects of the individual isomers of methadone after acute and chronic administrations.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administ | 2011 |
Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids.
Topics: Adenosine; Amines; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Cyclohexanecarboxylic | 2011 |
(1) H-nuclear magnetic resonance-based metabonomic analysis of brain in rhesus monkeys with morphine treatment and withdrawal intervention.
Topics: Animals; Brain; Disease Models, Animal; Female; Macaca mulatta; Magnetic Resonance Spectroscopy; Mal | 2012 |
Methadone diminishes neuroinflammation and disease severity in EAE through modulating T cell function.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Disease Models, Animal; Encephalomyelitis, Autoimmune, | 2013 |
Discrimination of a single dose of morphine followed by naltrexone: substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependence.
Topics: Acute Disease; Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Male; Methadone; Morph | 2003 |
[Vaccine, methadone and zebrafish].
Topics: Animals; Cocaine-Related Disorders; Disease Models, Animal; Methadone; Narcotics; Vaccines; Zebrafis | 2003 |
Methadone maintenance reduces heroin- and cocaine-induced relapse without affecting stress-induced relapse in a rodent model of poly-drug use.
Topics: Analysis of Variance; Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Disease Models, Anima | 2004 |
(S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone.
Topics: Analgesics, Opioid; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Immunosupp | 2004 |
Comparative actions of the opioid analgesics morphine, methadone and codeine in rat models of peripheral and central neuropathic pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Codeine; Disease Models, Animal; Male; Methadone; Mor | 2005 |
Reversal of morphine, methadone and heroin induced effects in mice by naloxone methiodide.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Drug Interactions; Female; Heroin; Male; Methad | 2006 |
Choice between heroin and food in nondependent and heroin-dependent rhesus monkeys: effects of naloxone, buprenorphine, and methadone.
Topics: Animals; Buprenorphine; Disease Models, Animal; Feeding Behavior; Heroin; Heroin Dependence; Macaca | 2006 |
Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior.
Topics: 5-Hydroxytryptophan; Analgesics, Opioid; Animals; Clozapine; Desipramine; Disease Models, Animal; Do | 2007 |
Characterization of the antinociceptive and pronociceptive effects of methadone in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hot T | 2007 |
Characterization of the antinociceptive and pronociceptive effects of methadone in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hot T | 2007 |
Characterization of the antinociceptive and pronociceptive effects of methadone in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hot T | 2007 |
Characterization of the antinociceptive and pronociceptive effects of methadone in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hot T | 2007 |
Methadone-induced respiratory depression in the neonatal guinea pig.
Topics: Animals; Animals, Newborn; Blood Gas Analysis; Breath Tests; Carbon Dioxide; Disease Models, Animal; | 2007 |
Comparison of buprenorphine and methadone effects on opiate self-administration in primates.
Topics: Animals; Buprenorphine; Depression, Chemical; Disease Models, Animal; Feeding Behavior; Heroin; Huma | 1983 |
Effect of chronic methadone administration on neuroendocrine function in developing rats.
Topics: Age Factors; Animals; Body Weight; Corticosterone; Disease Models, Animal; Female; Growth Hormone; L | 1984 |
Phencyclidine-induced stereotype in rats: effects of methadone, apomorphine, and naloxone.
Topics: Animals; Apomorphine; Brain Chemistry; Disease Models, Animal; Humans; Male; Methadone; Motor Activi | 1981 |
Thrombocytosis in the offspring of female mice receiving DL-methadone.
Topics: Animals; Animals, Newborn; Bone Marrow Cells; Disease Models, Animal; Female; Hematopoiesis; Megakar | 1980 |
The N-methyl-D-aspartate antagonistic and opioid components of d-methadone antinociception in the rat spinal cord.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesia; Analgesics, | 2000 |
Reduced tolerance to the anti-hyperalgesic effect of methadone in comparison to morphine in a rat model of mononeuropathy.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Drug Tolerance; Hyperalgesia; Male; Methadone; | 2002 |
Animal-human correlates of narcotic dependence: a brief review.
Topics: Animals; Behavior Therapy; Conditioning, Operant; Disease Models, Animal; Dogs; Drug Tolerance; Hapl | 1978 |
Objective tests of analgesic drugs in ponies.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Fentanyl; Horse Diseases; Horses; Male; Meperid | 1979 |
Intragastric self-administration of psychoactive drugs by the rhesus monkey.
Topics: Animals; Dextroamphetamine; Disease Models, Animal; Ethanol; Haplorhini; Humans; Macaca mulatta; Met | 1975 |
Drugs as reinforcers in monkey and man.
Topics: Animals; Codeine; Disease Models, Animal; Drug Therapy; Haplorhini; Heroin Dependence; Humans; Legis | 1975 |
Profile of opioid withdrawal in newly hatched chickens.
Topics: Animals; Arousal; Brain; Chick Embryo; Chickens; Disease Models, Animal; Dose-Response Relationship, | 1989 |
Endocrine consequences of perinatal methadone exposure.
Topics: Aging; Animals; Animals, Newborn; Cyproheptadine; Disease Models, Animal; Hypothalamo-Hypophyseal Sy | 1987 |
A rat model of methadone addiction.
Topics: Animals; Behavior, Animal; Body Weight; Disease Models, Animal; Drinking Behavior; Drug Tolerance; F | 1974 |
Resumption of morphine self-administration by ex-addict rats: an attempt to modify tendencies to relapse.
Topics: Animals; Disease Models, Animal; Drinking Behavior; Humans; Male; Methadone; Morphine; Morphine Depe | 1972 |