methadone and Depression studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

Excerpt	Relevance	Reference
"These results suggest that depression need not be considered a common adverse effect of naltrexone treatment or a treatment contraindication and that engaging with or adhering to naltrexone treatment may be associated with fewer depressive symptoms."	9.12	Does naltrexone treatment lead to depression? Findings from a randomized controlled trial in subjects with opioid dependence. ( Connor, JP; Dean, AJ; Jones, RT; Lawford, BR; Saunders, JB; Young, RM, 2006)
"This study tested the effectiveness of fluoxetine as a treatment for depression in a population of methadone-maintained opioid addicts."	9.08	Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts. ( Carroll, KM; Gordon, L; Kosten, T; Nich, C; Petrakis, I; Rounsaville, B, 1998)
"The results of the present study show that methadone significantly reduces depression in addicts."	9.05	The effect of methadone on depression among addicts: a systematic review and meta-analysis. ( Abdoli, N; Hosseinian-Far, M; Kazeminia, M; Khaledipaveh, B; Mohammadi, M; Salari, N; Shohaimi, S, 2020)
"This study was designed to examine whether treadmill exercise would attenuate the severity of physical dependence, methadone-induced anxiety, depression and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment (MMT)."	7.88	Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment. ( Alizadeh, M; Miladi-Gorji, H; Zahedi-Khorasani, M, 2018)
" Methadone maintenance treatment (MMT) is an evidence-based effective treatment for drug addiction; however, there are few studies investigating depression, suicidal ideation, and their related factors among MMT users."	7.83	Depression, suicidal ideation, and related factors of methadone maintenance treatment users in Guangzhou, China. ( Davis, A; Gu, J; Hao, C; Hao, Y; Lau, JT; Xu, H; Zhang, X; Zhao, Y, 2016)
"We tested an interaction between substance use and depression on HAART adherence among methadone maintenance patients."	7.81	The interaction of active substance use, depression, and antiretroviral adherence in methadone maintenance. ( Berg, KM; Gonzalez, JS; Newville, H, 2015)
"A considerable proportion of methadone maintenance treatment clients in China have experienced depression and anxiety during treatment."	7.81	Factors associated with depression and anxiety among patients attending community-based methadone maintenance treatment in China. ( Cao, X; Li, J; Li, Z; Liu, M; McGoogan, JM; Pang, L; Rou, K; Yin, W; Zhang, C, 2015)
"Risk factors in older methadone maintenance treatment (MMT) patients may put them at a greater risk of acquiring chronic diseases; however, this group might experience barriers to treatment resulting in reduced recommended prescriptions."	7.79	Hypertension, chronic obstructive pulmonary disease, diabetes and depression among older methadone maintenance patients in British Columbia. ( Borycki, E; Macdonald, S; Maruyama, A; Zhao, J, 2013)
"Depression and hepatitis C virus (HCV) infection are two common conditions among heroin users in methadone maintenance treatment (MMT)."	7.79	Hepatitis C virus infection is independently associated with depression among methadone maintenance treatment heroin users in China. ( Du, J; Mandel, JS; Page, K; Wang, Z; Xiao, Z; Zhao, M, 2013)
" The group on methadone had a strong depression in all three measurements."	7.78	[Differences in depression severity and frequency of relapses in opiate addicts treated with methadone or opiate blocker after detoxification]. ( Jovanović, T; Lazarević, D; Nikolić, G, 2012)
"The aim of this study was to examine the association of pain catastrophizing and pain coping strategies with characteristic pain intensity (an average of worst, least, and typical pain intensity in the past week) and recent pain-related disability (an average of three measures of past week pain interference) in opioid-dependent patients enrolled in a methadone maintenance treatment program (MMTP) who reported recent pain."	7.77	Pain catastrophizing and pain coping among methadone-maintained patients. ( Barry, DT; Beitel, M; Cutter, CJ; Garnet, B; Peters, S; Savant, J; Schottenfeld, RS, 2011)
"Our data show a higher level of nicotine dependence and depression, and greater readiness to change among women smokers in methadone maintenance programmes compared to women smokers attending primary care clinics."	7.76	Nicotine dependence and depression among women smokers on methadone maintenance. ( Arnold, S; Gandhi, D; Joshi, A; Khanna, N; Sadaphal, S; Stewart, D, 2010)
" In this study, we examined the link between resting rCBF in the PFC and current depressive symptoms in methadone-maintained opiate-dependent (MM) patients with or without major depression."	7.75	Low prefrontal perfusion linked to depression symptoms in methadone-maintained opiate-dependent patients. ( Busch, SI; Childress, AR; Ehrman, RN; Hakun, JG; Langleben, DD; Li, Y; O'Brien, CP; Suh, JJ; Wang, Z, 2009)
" Because a history of depression has been shown in other populations to complicate cessation efforts, the relationship between depression and nicotine dependence was tested in 726 methadone patients."	7.69	Nicotine dependence and depression among methadone maintenance patients. ( Brown, LS; Lin, MM; Meyer, TJ, 1996)
"Alcoholism is a prevalent problem encountered during the methadone treatment of opioid dependence."	7.68	The relationship of mean daily blood alcohol levels to admission MAST, clinic absenteeism and depression in alcoholic methadone patients. ( Amass, L; Bickel, WK, 1993)
"An atypical depression, resembling beta-phenylethylamine (PEA) deficiency states, frequently complicates methadone withdrawal."	7.67	Depression during methadone withdrawal: no role for beta-phenylethylamine. ( Chuang, LW; Karoum, F; Kaufmann, CA; Kreek, MJ, 1984)
"In a study of 106 predominantly young, lower-social-class men participating in a methadone maintenance program, the authors found that about one-third were moderately to severely depressed as assessed on standard rating scales of depression."	7.65	Clinical depression among narcotic addicts maintained on methadone in the community. ( Howard, P; Mezritz, M; Prusoff, B; Slobetz, F; Weissman, MM, 1976)
"Methadone Maintenance Treatment (MMT) can be associated with severe stress and mild to moderate depressive symptoms."	7.30	The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. ( Bateni, A; Goli, R; Lagzi, N; Talebiazar, N, 2023)
"Substance addiction is damaging to the health of persons, families, and society."	6.49	Spirituality, religiosity, depression, anxiety, and drug-use consequences during methadone maintenance therapy. ( Piacentine, LB, 2013)
"Even though depression is common among men on MMT, it is often missed by the treating doctors."	5.39	Depression in male patients on methadone maintenance therapy. ( Baharudin, A; Ibrahim, N; Mislan, N; Nik Jaafar, NR; Sidi, H, 2013)
"Hypogonadism was found in 68 % of the participants, and about 68."	5.38	Depression, Testosterone concentration, sexual dysfunction and methadone use among men with hypogonadism and HIV Infection. ( Amini Lari, M; Faramarzi, H; Marzban, M; Parsa, N; Shams, M, 2012)
"Clinicians rated substance abuse using the Clinical Global Impression Scale and a structured interview."	5.37	Clinician-assessed depression and HAART adherence in HIV-infected individuals in methadone maintenance treatment. ( Applebaum, A; Batchelder, A; Gonzalez, JS; Newville, H; Psaros, C; Safren, SA, 2011)
"57% had a current non-substance use psychiatric disorder."	5.35	Health-related quality of life in methadone maintenance patients with untreated hepatitis C virus infection. ( Batki, SL; Canfield, KM; Ploutz-Snyder, R; Smyth, E, 2009)
"Menopause is a natural process that occurs in women's lives as part of normal aging."	5.34	Exploring the prevalence of menopause symptoms in midlife women in methadone maintenance treatment. ( Tuchman, E, 2007)
"Methadone maintenance treatment (MMT) might be associated with the symptoms of depression and anxiety, sleep disturbances and sexual dysfunctions."	5.30	The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial. ( Asemi, Z; Banafshe, HR; Ghaderi, A; Khalatbari-Mohseni, A; Mirhosseini, N; Omidi, A, 2019)
"The aims of this pilot study were: (a) to test the feasibility of prolonged exposure (PE) therapy conducted by a social worker staff on female patients in methadone program clinics who were survivors of child sexual abuse or rape and (b) to examine preliminary outcomes of PE on posttraumatic stress disorder (PTSD), depression, and illicit drug use at pre- and posttreatment, and up to 12-month follow-ups."	5.20	Prolonged Exposure for Treating PTSD Among Female Methadone Patients Who Were Survivors of Sexual Abuse in Israel. ( Foa, EB; Katz, N; Levit, S; Nacasch, N; Schiff, M, 2015)
"According to this clinical trial, Olanzapine and Sertraline are effective in ameliorating symptoms of depression, anxiety and aggression, reducing sensitivity in interpersonal relationships and alleviating obsessive symptoms, pessimistic behaviors and somatization disorders in patients with personality disorders on methadone maintenance therapy."	5.14	The effect of Olanzapine and Sertraline on personality disorder in patients with methadone maintenance therapy. ( Birjandi, M; Jariani, M; Nazari, H; Saaki, M, 2010)
"These results suggest that depression need not be considered a common adverse effect of naltrexone treatment or a treatment contraindication and that engaging with or adhering to naltrexone treatment may be associated with fewer depressive symptoms."	5.12	Does naltrexone treatment lead to depression? Findings from a randomized controlled trial in subjects with opioid dependence. ( Connor, JP; Dean, AJ; Jones, RT; Lawford, BR; Saunders, JB; Young, RM, 2006)
" The Beck Depression Inventory was completed at baseline and 3 months by heroin dependent subjects receiving either buprenorphine or methadone maintenance as part of a larger, pre-existing, double blind trial conducted by NDARC (Australia)."	5.11	Depressive symptoms during buprenorphine vs. methadone maintenance: findings from a randomised, controlled trial in opioid dependence. ( Bell, J; Christie, MJ; Dean, AJ; Mattick, RP, 2004)
"Stabilised MMPs scoring over 21 on the Beck Depression Inventory were randomised to receive fluoxetine or placebo over 12 weeks."	5.10	A randomised, controlled trial of fluoxetine in methadone maintenance patients with depressive symptoms. ( Bell, J; Christie, MJ; Dean, AJ; Mascord, DJ; Parker, G, 2002)
"This study tested the effectiveness of fluoxetine as a treatment for depression in a population of methadone-maintained opioid addicts."	5.08	Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts. ( Carroll, KM; Gordon, L; Kosten, T; Nich, C; Petrakis, I; Rounsaville, B, 1998)
"The results of the present study show that methadone significantly reduces depression in addicts."	5.05	The effect of methadone on depression among addicts: a systematic review and meta-analysis. ( Abdoli, N; Hosseinian-Far, M; Kazeminia, M; Khaledipaveh, B; Mohammadi, M; Salari, N; Shohaimi, S, 2020)
"Anxiety, an important factor that affects the therapeutic effect and preservation rate of methadone maintenance treatment, has a high prevalence among MMT patients."	4.02	Effects of treatment status and life quality on anxiety in MMT patients. ( Cao, P; Fan, N; Huang, Q; Xu, S; Zhang, Z; Zhong, J, 2021)
"Examinees were patients with chronic hepatitis C on interferon therapy, which we divided into three groups: those who were never addicts, then the group of patients who were earlier addicts and have a long abstinence and patients who treat their addiction with a replacement therapy of methadone or buprenorphine."	3.96	Depression Disorders in Patients with Chronic Hepatitis C. ( Bebek-Ivankovic, H; Bevanda, M; Grgic, S; Nikolic, J; Soldo-Coric, L; Susak, B, 2020)
"This study was designed to examine whether treadmill exercise would attenuate the severity of physical dependence, methadone-induced anxiety, depression and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment (MMT)."	3.88	Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment. ( Alizadeh, M; Miladi-Gorji, H; Zahedi-Khorasani, M, 2018)
" Methadone maintenance treatment (MMT) is an evidence-based effective treatment for drug addiction; however, there are few studies investigating depression, suicidal ideation, and their related factors among MMT users."	3.83	Depression, suicidal ideation, and related factors of methadone maintenance treatment users in Guangzhou, China. ( Davis, A; Gu, J; Hao, C; Hao, Y; Lau, JT; Xu, H; Zhang, X; Zhao, Y, 2016)
"We tested an interaction between substance use and depression on HAART adherence among methadone maintenance patients."	3.81	The interaction of active substance use, depression, and antiretroviral adherence in methadone maintenance. ( Berg, KM; Gonzalez, JS; Newville, H, 2015)
"A considerable proportion of methadone maintenance treatment clients in China have experienced depression and anxiety during treatment."	3.81	Factors associated with depression and anxiety among patients attending community-based methadone maintenance treatment in China. ( Cao, X; Li, J; Li, Z; Liu, M; McGoogan, JM; Pang, L; Rou, K; Yin, W; Zhang, C, 2015)
"Interpersonal sensitivity level in methadone maintenance treatment was higher than normal and depression; anxiety and depression both were the risk factors of interpersonal sensitivity level."	3.81	[Association between negative emotion and interpersonal sensitivity among patients in methadone maintenance treatment]. ( Deng, H; Li, J; Lu, Z; Xu, G; Yang, J, 2015)
"The current study examined (1) the association between recent IPV victimization and alcohol and cocaine use and (2) the relationship between recent IPV victimization and depression in a sample of smokers (N = 203) in methadone maintenance treatment (MMT)."	3.80	Intimate partner violence among individuals in methadone maintenance treatment. ( Anderson, BJ; Caviness, CM; de Dios, MA; Stein, M, 2014)
"Depression and hepatitis C virus (HCV) infection are two common conditions among heroin users in methadone maintenance treatment (MMT)."	3.79	Hepatitis C virus infection is independently associated with depression among methadone maintenance treatment heroin users in China. ( Du, J; Mandel, JS; Page, K; Wang, Z; Xiao, Z; Zhao, M, 2013)
"Risk factors in older methadone maintenance treatment (MMT) patients may put them at a greater risk of acquiring chronic diseases; however, this group might experience barriers to treatment resulting in reduced recommended prescriptions."	3.79	Hypertension, chronic obstructive pulmonary disease, diabetes and depression among older methadone maintenance patients in British Columbia. ( Borycki, E; Macdonald, S; Maruyama, A; Zhao, J, 2013)
" This study explores the correlates of depression among a sample of methadone maintained treatment (MMT) adults in the Los Angeles area, and is part of a larger study on hepatitis health promotion among MMT clients who use alcohol."	3.78	Correlates of depressive symptoms among alcohol-using methadone maintained adults. ( Albarrán, CR; Branson, C; Khalilifard, F; Leake, B; Marfisee, M; Nyamathi, A, 2012)
" The group on methadone had a strong depression in all three measurements."	3.78	[Differences in depression severity and frequency of relapses in opiate addicts treated with methadone or opiate blocker after detoxification]. ( Jovanović, T; Lazarević, D; Nikolić, G, 2012)
"The aim of this study was to examine the association of pain catastrophizing and pain coping strategies with characteristic pain intensity (an average of worst, least, and typical pain intensity in the past week) and recent pain-related disability (an average of three measures of past week pain interference) in opioid-dependent patients enrolled in a methadone maintenance treatment program (MMTP) who reported recent pain."	3.77	Pain catastrophizing and pain coping among methadone-maintained patients. ( Barry, DT; Beitel, M; Cutter, CJ; Garnet, B; Peters, S; Savant, J; Schottenfeld, RS, 2011)
"The aims of this study were to compare the quality of life (QOL) between subjects with and without heroin use and to examine the association of QOL with sociodemographic characteristics, characteristics of heroin use, family support, and depression among heroin users at entry to a methadone maintenance treatment program."	3.77	Quality of life and its correlates among heroin users in Taiwan. ( Chang, HC; Chen, HF; Wang, CS; Wang, TY; Yen, CN, 2011)
"Our data show a higher level of nicotine dependence and depression, and greater readiness to change among women smokers in methadone maintenance programmes compared to women smokers attending primary care clinics."	3.76	Nicotine dependence and depression among women smokers on methadone maintenance. ( Arnold, S; Gandhi, D; Joshi, A; Khanna, N; Sadaphal, S; Stewart, D, 2010)
"This retrospective study evaluated the efficacy and tolerability of directly observed therapy with peginterferon alfa-2a and once-daily ribavirin (RBV) for chronic hepatitis C in 49 opioid-addicted injection drug users (IDUs) participating in a drug treatment program at a specialized outpatient center."	3.76	High rates of sustained virological response in hepatitis C virus-infected injection drug users receiving directly observed therapy with peginterferon alpha-2a (40KD) (PEGASYS) and once-daily ribavirin. ( Ackermann, G; Waizmann, M, 2010)
" In this study, we examined the link between resting rCBF in the PFC and current depressive symptoms in methadone-maintained opiate-dependent (MM) patients with or without major depression."	3.75	Low prefrontal perfusion linked to depression symptoms in methadone-maintained opiate-dependent patients. ( Busch, SI; Childress, AR; Ehrman, RN; Hakun, JG; Langleben, DD; Li, Y; O'Brien, CP; Suh, JJ; Wang, Z, 2009)
" The current study assessed anxiety, depression, hostility and alexithymia levels in 70 methadone maintenance treatment patients."	3.74	Self-medication hypothesis of substance use: testing Khantzian's updated theory. ( Hall, DH; Queener, JE, 2007)
"Five adult methadone-maintained cocaine abusers."	3.70	Effects of "binge" use of intravenous cocaine in methadone-maintained individuals. ( Fischman, MW; Foltin, RW, 1998)
" Because a history of depression has been shown in other populations to complicate cessation efforts, the relationship between depression and nicotine dependence was tested in 726 methadone patients."	3.69	Nicotine dependence and depression among methadone maintenance patients. ( Brown, LS; Lin, MM; Meyer, TJ, 1996)
"Alcoholism is a prevalent problem encountered during the methadone treatment of opioid dependence."	3.68	The relationship of mean daily blood alcohol levels to admission MAST, clinic absenteeism and depression in alcoholic methadone patients. ( Amass, L; Bickel, WK, 1993)
"Self-reported depressive symptoms of opiate addicts were assessed at admission to a methadone treatment program and weekly during the first 4 treatment weeks using the Beck Depression Inventory."	3.68	Early treatment time course of depressive symptoms in opiate addicts. ( Bigelow, GE; Stitzer, ML; Strain, EC, 1991)
"An atypical depression, resembling beta-phenylethylamine (PEA) deficiency states, frequently complicates methadone withdrawal."	3.67	Depression during methadone withdrawal: no role for beta-phenylethylamine. ( Chuang, LW; Karoum, F; Kaufmann, CA; Kreek, MJ, 1984)
" A principal factor analysis of the men's self-ratings revealed four major dimensions-Fatigue-inertia, Confused-depression, Anger-hostility, and Friendliness; these dimensions were similar to factors reported for male psychiatric patients, but only the dimensions of Fatigue-inertia, Confused-depression, and Anger-hostility matched comparable factors reported for male heroin addicts seeking methadone maintenance."	3.66	Affect dimensions of male heroin addicts admitted for inpatient detoxification. ( Schut, J; Steer, RA, 1981)
"In a study of 106 predominantly young, lower-social-class men participating in a methadone maintenance program, the authors found that about one-third were moderately to severely depressed as assessed on standard rating scales of depression."	3.65	Clinical depression among narcotic addicts maintained on methadone in the community. ( Howard, P; Mezritz, M; Prusoff, B; Slobetz, F; Weissman, MM, 1976)
"gov identifier: NCT03033732), a pragmatic randomised controlled trial comparing flexible take-home dosing of BUP/NX and methadone standard model of care for reducing opioid use in people with POUD."	3.30	Effects of Buprenorphine/Naloxone and Methadone on Depressive Symptoms in People with Prescription Opioid Use Disorder: A Pragmatic Randomised Controlled Trial. ( Bastien, G; Brissette, S; Hassan, AN; Jutras-Aswad, D; Le Foll, B; Ledjiar, O; Lim, R; Marsan, S; McAnulty, C; Socias, ME; Talbot, A, 2023)
"Methadone Maintenance Treatment (MMT) can be associated with severe stress and mild to moderate depressive symptoms."	3.30	The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. ( Bateni, A; Goli, R; Lagzi, N; Talebiazar, N, 2023)
"(1) Methadone was associated with normalisation of dorsal ACC biochemistry (increased N-acetylaspartate and glutamate/glutamine levels, and decreased myo-inositol levels) in a dose-dependent manner; (2) buprenorphine-treated individuals had higher myo-inositol and glutamate/glutamine levels than methadone-treated patients in the right dorsal ACC; and (3) myo-inositol levels were positively correlated with depressive symptoms in participants stabilised on buprenorphine."	2.78	Cingulate biochemistry in heroin users on substitution pharmacotherapy. ( Bora, E; Lubman, DI; MacKenzie, T; Roffel, K; Verdejo-García, A; Vilar-López, R; Yücel, M, 2013)
"Substance addiction is damaging to the health of persons, families, and society."	2.49	Spirituality, religiosity, depression, anxiety, and drug-use consequences during methadone maintenance therapy. ( Piacentine, LB, 2013)
"Methadone has improved our understanding of these pathologies."	2.39	Treatment of depressive syndromes in detoxified drug addicts: use of methadone. ( Baylé, FJ; Jalfre, V; Laqueille, X; Lôo, H; Spadone, C, 1996)
"A review of the literature on multiple drug abuse involving two or more drug categories, where at least one is a nonopiate, nonalcoholic substance (MDA-NONA), revealed that Whites and, to a lesser extent, females are overly represented, disproportionate to their composition in other patterns of drug use."	2.36	Multiple drug abuse involving nonopiate, nonalcoholic substances. I. Prevalence. ( Kornblith, AB, 1981)
"Methadone maintenance is an effective treatment for opioid use disorder, yet many methadone-maintained patients (MMPs) continue to struggle with chronic relapse."	1.51	Prefrontal cortex response to drug cues, craving, and current depressive symptoms are associated with treatment outcomes in methadone-maintained patients. ( Ayaz, H; Brooner, RK; Dunn, KE; Huhn, AS; Kidorf, MS; Sweeney, MM; Tompkins, DA, 2019)
"To develop more effective treatments for heroin abusers, a comprehensive psychosocial model of heroin use should be established and examined."	1.48	The relationships between depression, neuroticism, and attitudes (NDA model) in heroin abusers in Taiwan. ( Lee, KH; Yen, CF, 2018)
"Methadone has been recognized as an effective maintenance treatment for opioid dependence."	1.48	Plasma Testosterone and Sexual Function in Southeast Asian Men Receiving Methadone and Buprenorphine Maintenance Treatment. ( Danaee, M; Loh, HS; Ng, CG; Riahi, S; Sulaiman, AH; Yee, A, 2018)
"Chronic pain was present in 68% of the sample, 51% reported craving opioids in the past week, and 16% had a positive UDT."	1.43	Chronic pain, craving, and illicit opioid use among patients receiving opioid agonist therapy. ( Alford, DP; Cheng, DM; Edwards, RR; Liebschutz, JM; Lira, MC; Samet, JH; Tsui, JI; Winter, MR, 2016)
"QoL, substance use, mental and physical comorbidities, and exercise behaviors were measured."	1.43	Many correlates of poor quality of life among substance users entering treatment are not addiction-specific. ( Clausen, T; Muller, AE; Skurtveit, S, 2016)
" High heroin expenses, more severe harm caused by heroin use, perceived lower family support, and lower methadone dosage at 3 months after starting MMT increased the risk of dropout in the follow-up period."	1.39	Predictors for dropping-out from methadone maintenance therapy programs among heroin users in southern Taiwan. ( Chang, HC; Chen, KY; Chung, KS; Lin, HC; Wang, PW; Wu, HC; Yeh, YC; Yen, CF; Yen, CN, 2013)
"Even though depression is common among men on MMT, it is often missed by the treating doctors."	1.39	Depression in male patients on methadone maintenance therapy. ( Baharudin, A; Ibrahim, N; Mislan, N; Nik Jaafar, NR; Sidi, H, 2013)
" Data on methadone dosage at each follow-up interview and the duration of retention in the MMT program were also collected."	1.38	Predictors of the severity of depressive symptoms among intravenous heroin users receiving methadone maintenance treatment in Taiwan: an 18-month follow-up study. ( Chang, HC; Chung, KS; Wang, PW; Wu, HC; Yeh, YC; Yen, CF; Yen, CN, 2012)
"Hypogonadism was found in 68 % of the participants, and about 68."	1.38	Depression, Testosterone concentration, sexual dysfunction and methadone use among men with hypogonadism and HIV Infection. ( Amini Lari, M; Faramarzi, H; Marzban, M; Parsa, N; Shams, M, 2012)
"Clinicians rated substance abuse using the Clinical Global Impression Scale and a structured interview."	1.37	Clinician-assessed depression and HAART adherence in HIV-infected individuals in methadone maintenance treatment. ( Applebaum, A; Batchelder, A; Gonzalez, JS; Newville, H; Psaros, C; Safren, SA, 2011)
"57% had a current non-substance use psychiatric disorder."	1.35	Health-related quality of life in methadone maintenance patients with untreated hepatitis C virus infection. ( Batki, SL; Canfield, KM; Ploutz-Snyder, R; Smyth, E, 2009)
"Recent clinical studies suggest that substance use may be associated with an acceleration of the ageing process, possibly related to a deficit of stem cell number or function."	1.35	An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey. ( Reece, AS, 2008)
"Menopause is a natural process that occurs in women's lives as part of normal aging."	1.34	Exploring the prevalence of menopause symptoms in midlife women in methadone maintenance treatment. ( Tuchman, E, 2007)
"Preexisting psychiatric disorders or present methadone substitution should no longer be regarded as contraindications to treatment of chronic hepatitis C with IFN-alpha and ribavirin in an interdisciplinary setting."	1.32	Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups. ( Folwaczny, C; Grunze, H; Heldwein, W; Koenig, A; Loeschke, K; Lorenz, R; Martin, G; Schaefer, M; Schindlbeck, N; Schmidt, F; Soyka, M, 2003)
"The origin of the psychiatric illnesses observed in drug abusers is often unclear."	1.26	Development of psychiatric illness in drug abusers. Possible role of drug preference. ( Mc Lellan, AT; O'Brien, CP; Woody, GE, 1979)
"Confused-depression was positively correlated with being White, using marijuana, and seeking treatment without prior screening by a social agency; Vigor-friendliness was positively related to having been referred from a social agency and having started using opiates at a later age; Anger-hostility was positively correlated with using other drugs, such as Valium, not being religiously active, and smoking marijuana; and Fatigue-inertia was only positively associated with having been referred from a social agency."	1.26	Mood components of heroin addicted men: psychosocial correlates. ( Schut, J; Steer, RA, 1979)
" In the unblocked condition, patients initially experienced an increase in positive mood, but with chronic administration there was a significant rise in psychopathology and the development of a generalized dysphoric state."	1.26	Psychopathology, craving, and mood during heroin acquisition: an experimental study. ( McDougle, M; McNamee, HB; Meyer, RE; Mirin, SM, 1976)

Research

Studies (144)

Authors

Clinical Trials (10)

Trial Overview

Trial Outcomes

Carbon Monoxide (CO)-Confirmed 7-day Abstinence

Timeframe	Studies, this research(%)	All Research%
pre-1990	48 (33.33)	18.7374
1990's	10 (6.94)	18.2507
2000's	19 (13.19)	29.6817
2010's	57 (39.58)	24.3611
2020's	10 (6.94)	2.80

Authors	Studies
Chang, TG	1
Yen, TT	1
Hsu, WY	1
Chang, SM	1
Bastien, G	2
McAnulty, C	2
Ledjiar, O	2
Socias, ME	2
Le Foll, B	2
Lim, R	2
Hassan, AN	2
Brissette, S	2
Marsan, S	2
Talbot, A	2
Jutras-Aswad, D	2
Ellis, JD	1
Lister, JJ	1
Wohl, MJA	1
Greenwald, MK	1
Ledgerwood, DM	1
Lagzi, N	1
Bateni, A	1
Goli, R	1
Talebiazar, N	1
Le, TA	1
Le, MQT	1
Dang, AD	1
Dang, AK	1
Nguyen, CT	1
Pham, HQ	1
Vu, GT	1
Hoang, CL	1
Tran, TT	1
Vuong, QH	1
Tran, TH	1
Tran, BX	1
Latkin, CA	1
Ho, CSH	1
Ho, RCM	1
Roos, CR	1
Kiluk, BD	1
McHugh, RK	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Behavioral Intervention to Improve Insomnia Symptoms in Patients With Opioid Use Disorder[NCT05588726]		0 participants (Actual)	Interventional	2022-01-01	Withdrawn (stopped due to Staff no longer available to continue enrollment and other research activities)
Varenicline Versus Nicotine Replacement for Methadone-Maintained Smokers[NCT00790569]		315 participants (Actual)	Interventional	2008-09-30	Completed
Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics[NCT04706624]		640 participants (Anticipated)	Interventional	2020-11-02	Active, not recruiting
Initialization of Methadone in Primary Care; a Randomized Intervention Research for Preventing HCV Transmission Practices. ANRS Methaville[NCT00657397]	Phase 3	197 participants (Actual)	Interventional	2009-01-31	Completed
Computer-Based Training in Cognitive Behavior Therapy[NCT00350610]	Phase 1	100 participants (Actual)	Interventional	2007-11-30	Completed
Feasibility, Mechanism of Action and Potential Side Effects of Extended Release Depot Naltrexone in Opioid Dependent Patients[NCT01471145]	Phase 4	40 participants (Anticipated)	Interventional	2013-01-31	Completed
Maternal Opioid Treatment: Human Experimental Research[NCT00271219]	Phase 3	175 participants (Actual)	Interventional	2005-07-31	Completed
MOms in REcovery (MORE): Defining Optimal Care for Pregnant Women and Infants[NCT04251208]		444 participants (Actual)	Observational	2019-07-30	Active, not recruiting
Treatment of Chronic Hepatitis c With Interferon-Alpha 2a and Ribavirin: a Comparison of Patients With Psychiatric Disorders and Controls[NCT00751426]		81 participants (Actual)	Observational	1999-08-31	Completed
Analgesic Efficacy of Testosterone Replacement in Hypogonadal Opioid-treated Chronic Pain Patients: A Pilot Study.[NCT00398034]	Phase 2	0 participants (Actual)	Interventional	2006-10-30	Withdrawn (stopped due to The original PI (David Siegel) Left the VA)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Number of participants reporting 7-day abstinence at 6-months, confirmed with CO measurement. (NCT00790569)
Timeframe: 6-Months

Change in Cigarettes Per Day

Change in Smoking Urges

Intervention	participants (Number)
Arm I	5
Arm II	1
Arm III	11

Intervention	cigarettes/day (Mean)
Arm I	-8.7
Arm II	-8.5
Arm III	-7.8

Smoking urges was measured on a 0 (not at all) - 100 (strongest feeling possible) scale. Higher values represent greater urge to smoke. Change in smoking urges was calculated as Follow-up score (6 month) - Baseline Score. (NCT00790569)
Timeframe: 6 months

CO-confirmed 7-day Abstinence

Intervention	units on a scale (Mean)
Arm I	-29.971
Arm II	-25.015
Arm III	-24.177

Number of participants reporting 7-day abstinence at 12-months, confirmed with CO measurement. (NCT00790569)
Timeframe: 12 Months

Rates of Smoking Cessation Continuous From First Quit Day to 6 Months

Intervention	participants (Number)
Arm I	4
Arm II	1
Arm III	8

Number of participants who self-reported continuous abstinence from their initial quit day (study day 14) to 6 Months (NCT00790569)
Timeframe: 6-Months

Reinforcing Effects of Smoking

Intervention	participants (Number)
Arm I	2
Arm II	0
Arm III	2

Reinforcing effects of smoking was measured using the modified version of the Cigarette Evaluation Questionnaire. Participants were asked to indicate on a 12-item scale how smoking made them feel in the prior 30 days on a scale from 1 (Not at all) to 7 (Extremely). Higher values indicated that smoking was a more positive experience for 10 of 12 items. Two items were reverse coded. Change in reinforcing effects of smoking was calculated as Follow-up score (6 month) - Baseline Score. (NCT00790569)
Timeframe: 6 months

Self- Reported 7-day Abstinence

Intervention	units on a scale (Mean)
Arm I	-1.005
Arm II	-.683
Arm III	-.761

Number of participants with self-reported, 7-day abstinence at 6-months (NCT00790569)
Timeframe: 6 Months

Self-reported 7-day Abstinence

Intervention	participants (Number)
Arm I	11
Arm II	3
Arm III	16

Number of participants with self-reported 7-day abstinence at 12-months (NCT00790569)
Timeframe: 12 Months

Withdrawal Symptoms

Intervention	participants (Number)
Arm I	4
Arm II	3
Arm III	11

Withdrawal Symptoms were measured using a modified version of the Minnesota Behavior Rating Scale. The scale asked subjects to rate their smoking withdrawal symptoms over the previous 24 hours on a scale from 0 (none) to 4 (severe). Higher values indicate more severe withdrawal symptoms. Change in withdrawal symptoms was calculated as Follow-up score (6 month) - Baseline Score. (NCT00790569)
Timeframe: 6 months

Child's Head Circumference Measurement (Measured at Birth)

Child's Length of Hospital Stay

Intervention	units on a scale (Mean)
Arm I	-.222
Arm II	-.163
Arm III	-.113

Intervention	cm (Mean)
A Methadone	33.0
B Buprenorphine	33.8

(NCT00271219)
Timeframe: delivery until hospital discharge (min=2 days, max=79 days)

Child's Peak Daily Total NAS Score

Intervention	days (Mean)
A Methadone	17.5
B Buprenorphine	10.0

NAS was measured with the MOTHER NAS scale, which includes 28 items, 19 of which are used for scoring and medication decisions. Scores can range from 0 to 42, with higher scores indicating more severe withdrawal. (NCT00271219)
Timeframe: minimum twice daily from birth until NAS no longer measured (min=10 days)

Mother's HIV Risk Behaviors (Measured Monthly by Risk Behavior Assessment)

Intervention	Score on the scale (Mean)
A Methadone	12.8
B Buprenorphine	11.0

(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)

Mother's Measures of Dose Adequacy and Acceptance Over Time (Measured Weekly by Dose Adequacy Measure)

Intervention	percentage of HIV risk behaviors (Number)
A Methadone	NA
B Buprenorphine	NA

Pregnant women maintained on an opioid agonist medication may require upward adjustment to their medication during the course of pregnant. The Dose Adequacy Measure represented a recordation of dosing adjustments during the course of the study. (NCT00271219)
Timeframe: from study entry until discontinuation or delivery (min=29 days, max=239 days)

Mother's Psychosocial Functioning at Delivery as Measured by the Addiction Severity Index Psychosocial Index Score

Intervention	dose increase per trimester (Number)
A Methadone	NA
B Buprenorphine	NA

The Addiction Severity Index is a structured clinical interview that assesses problem severity in 7 areas of functioning: alcohol use, drug use, medical, legal, employment, psychosocial, and psychiatric status. Each area of functioning yields a composite scale score between 0 and 1, with higher scores indicating greater problem severity in that area. Only the psychosocial index was examined in this study. (NCT00271219)
Timeframe: at delivery

Mother's Self-report of Drug Use (Measured Monthly by Time Line Follow Back)

Intervention	Score on the scale (Mean)
Methadone	.014
Buprenorphine	.088

(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)

Number of Children Requiring Treatment for Neonatal Abstinence Signs (NAS)

Intervention	percentage of drug use (Number)
A Methadone	NA
B Buprenorphine	NA

Neonatal abstinence syndrome (NAS) characterized by hyperirritability of the central nervous system and dysfunction in the autonomic nervous system, gastrointestinal tract, and respiratory system.11 When left untreated, NAS can result in serious illness (e.g., diarrhea, feeding difficulties, weight loss, and seizures) and death. (NCT00271219)
Timeframe: From birth until hospital discharge (min=4 days, max=10, depending on site)

Total Amount of Morphine Sulfate That a Neonate Receives to Treat NAS

Intervention	participants (Number)
A Methadone	41
B Buprenorphine	27

Total amount in mg (NCT00271219)
Timeframe: Start of NAS treatment until discontinuation of NAS treatment (min=0 days, max=76 days)

Article	Year
The effect of methadone on depression among addicts: a systematic review and meta-analysis. Health and quality of life outcomes, 2020, Nov-23, Volume: 18, Issue:1 Topics: Depression; Humans; Iran; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders	2020
Spirituality, religiosity, depression, anxiety, and drug-use consequences during methadone maintenance therapy. Western journal of nursing research, 2013, Volume: 35, Issue:6 Topics: Anxiety; Depression; Evidence-Based Nursing; Humans; Methadone; Spirituality; Substance-Related Diso	2013
Characterization of methadone overdose: clinical considerations and the scientific evidence. Therapeutic drug monitoring, 2002, Volume: 24, Issue:4 Topics: Depression; Diagnosis, Differential; Drug Overdose; Drug Tolerance; Forensic Medicine; Humans; Metha	2002
Multiple drug abuse involving nonopiate, nonalcoholic substances. I. Prevalence. The International journal of the addictions, 1981, Volume: 16, Issue:2 Topics: Alcoholism; Barbiturates; Depression; Female; Hallucinogens; Humans; Hypnotics and Sedatives; Male;	1981
Treatment of depressive syndromes in detoxified drug addicts: use of methadone. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1996, Volume: 50, Issue:6-7 Topics: Affective Disorders, Psychotic; Depression; Female; Humans; Male; Methadone; Opioid-Related Disorder	1996
[Actions and side effects of methadone]. Deutsche medizinische Wochenschrift (1946), 1990, Apr-06, Volume: 115, Issue:14 Topics: Depression; Humans; Methadone; Respiration; Substance-Related Disorders	1990
Opiate addiction: a critique of theory and some implications for treatment. American journal of psychotherapy, 1974, Volume: 28, Issue:1 Topics: Aggression; Anger; Anxiety; Conditioning, Psychological; Depression; Euphoria; Humans; Methadone; Mo	1974

Article	Year
Effects of Buprenorphine/Naloxone and Methadone on Depressive Symptoms in People with Prescription Opioid Use Disorder: A Pragmatic Randomised Controlled Trial. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2023, Volume: 68, Issue:8 Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Canada; Depression; Hum	2023
Effects of Buprenorphine/Naloxone and Methadone on Depressive Symptoms in People with Prescription Opioid Use Disorder: A Pragmatic Randomised Controlled Trial. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2023, Volume: 68, Issue:8 Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Canada; Depression; Hum	2023
Effects of Buprenorphine/Naloxone and Methadone on Depressive Symptoms in People with Prescription Opioid Use Disorder: A Pragmatic Randomised Controlled Trial. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2023, Volume: 68, Issue:8 Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Canada; Depression; Hum	2023
Effects of Buprenorphine/Naloxone and Methadone on Depressive Symptoms in People with Prescription Opioid Use Disorder: A Pragmatic Randomised Controlled Trial. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2023, Volume: 68, Issue:8 Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Canada; Depression; Hum	2023
The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. International journal of psychiatry in medicine, 2023, Volume: 58, Issue:6 Topics: Adult; Anxiety; Depression; Folic Acid; Humans; Male; Methadone; Middle Aged; Vitamins	2023
Evaluating a longitudinal mediation model of perceived stress, depressive symptoms, and substance use treatment outcomes. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2020, Volume: 34, Issue:6 Topics: Adult; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Depression; Female; Galantamine; Hum	2020
The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment. Addiction biology, 2019, Volume: 24, Issue:4 Topics: Adult; Analgesics, Opioid; Antioxidants; Anxiety; Blood Glucose; C-Reactive Protein; Cholesterol, HD	2019
Transcranial Direct Current Stimulation on Opium Craving, Depression, and Anxiety: A Preliminary Study. The journal of ECT, 2019, Volume: 35, Issue:3 Topics: Adolescent; Adult; Anxiety; Combined Modality Therapy; Craving; Depression; Humans; Male; Methadone;	2019
The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial. Substance abuse treatment, prevention, and policy, 2019, 02-22, Volume: 14, Issue:1 Topics: Adult; Anxiety; Carotenoids; Depression; Double-Blind Method; Drug Therapy, Combination; Humans; Met	2019
Prolonged Exposure for Treating PTSD Among Female Methadone Patients Who Were Survivors of Sexual Abuse in Israel. Social work in health care, 2015, Volume: 54, Issue:8 Topics: Adult; Adult Survivors of Child Abuse; Child; Child Abuse, Sexual; Depression; Female; Humans; Implo	2015
Correlates of cocaine use during methadone treatment: implications for screening and clinical management (ANRS Methaville study). Harm reduction journal, 2016, Apr-05, Volume: 13 Topics: Adult; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Cocaine-Related Disorders; C	2016
Correlates of cocaine use during methadone treatment: implications for screening and clinical management (ANRS Methaville study). Harm reduction journal, 2016, Apr-05, Volume: 13 Topics: Adult; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Cocaine-Related Disorders; C	2016
Correlates of cocaine use during methadone treatment: implications for screening and clinical management (ANRS Methaville study). Harm reduction journal, 2016, Apr-05, Volume: 13 Topics: Adult; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Cocaine-Related Disorders; C	2016
Correlates of cocaine use during methadone treatment: implications for screening and clinical management (ANRS Methaville study). Harm reduction journal, 2016, Apr-05, Volume: 13 Topics: Adult; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Cocaine-Related Disorders; C	2016
Emotion regulation strategies in individuals with cocaine use disorder maintained on methadone. The American journal on addictions, 2016, Volume: 25, Issue:7 Topics: Adult; Analgesics, Opioid; Cocaine-Related Disorders; Cognition; Cognitive Behavioral Therapy; Combi	2016
Factors related to client satisfaction with methadone maintenance treatment in China. Journal of substance abuse treatment, 2017, Volume: 77 Topics: Adult; Age Factors; China; Counseling; Cross-Sectional Studies; Depression; Female; Humans; Male; Me	2017
Discrepancies in perceptions of maternal aggression: implications for children of methadone-maintained mothers. The American journal of orthopsychiatry, 2010, Volume: 80, Issue:3 Topics: Adolescent; Aggression; Child; Child Behavior Disorders; Child, Preschool; Depression; Female; Human	2010
The effect of Olanzapine and Sertraline on personality disorder in patients with methadone maintenance therapy. Psychiatria Danubina, 2010, Volume: 22, Issue:4 Topics: Adult; Aggression; Analgesics, Opioid; Anxiety; Benzodiazepines; Borderline Personality Disorder; De	2010
Cingulate biochemistry in heroin users on substitution pharmacotherapy. The Australian and New Zealand journal of psychiatry, 2013, Volume: 47, Issue:3 Topics: Adult; Aspartic Acid; Buprenorphine; Depression; Dose-Response Relationship, Drug; Female; Functiona	2013
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes. Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1 Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind	2012
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes. Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1 Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind	2012
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes. Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1 Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind	2012
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes. Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1 Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind	2012
A randomised, controlled trial of fluoxetine in methadone maintenance patients with depressive symptoms. Journal of affective disorders, 2002, Volume: 72, Issue:1 Topics: Adult; Antidepressive Agents; Comorbidity; Depression; Female; Fluoxetine; Humans; Male; Methadone;	2002
The effect of sertraline and environmental context on treating depression and illicit substance use among methadone maintained opiate dependent patients: a controlled clinical trial. Drug and alcohol dependence, 2004, May-10, Volume: 74, Issue:2 Topics: Adult; Depression; Diagnostic and Statistical Manual of Mental Disorders; Double-Blind Method; Envir	2004
Depressive symptoms during buprenorphine vs. methadone maintenance: findings from a randomised, controlled trial in opioid dependence. European psychiatry : the journal of the Association of European Psychiatrists, 2004, Volume: 19, Issue:8 Topics: Adult; Buprenorphine; Depression; Female; Humans; Male; Methadone; Narcotic Antagonists; Narcotics;	2004
Does naltrexone treatment lead to depression? Findings from a randomized controlled trial in subjects with opioid dependence. Journal of psychiatry & neuroscience : JPN, 2006, Volume: 31, Issue:1 Topics: Adult; Depression; Female; Heroin Dependence; Humans; Male; Methadone; Naltrexone; Narcotic Antagoni	2006
Intravenous infusion of beta-endorphin increases serum prolactin, but not growth hormone or cortisol, in depressed subjects and withdrawing methadone addicts. The Journal of clinical endocrinology and metabolism, 1980, Volume: 50, Issue:6 Topics: Adult; Depression; Double-Blind Method; Endorphins; Female; Growth Hormone; Humans; Hydrocortisone;	1980
Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts. Drug and alcohol dependence, 1998, May-01, Volume: 50, Issue:3 Topics: Adult; Antidepressive Agents, Second-Generation; Behavior, Addictive; Cocaine; Cocaine-Related Disor	1998
[Economic evaluation in a trial of medically controlled prescription of narcotics to dependent users (PROVE)]. Sozial- und Praventivmedizin, 1998, Volume: 43, Issue:4 Topics: Depression; Digestive System Diseases; Drug Prescriptions; Epilepsy; Health Care Costs; Heroin; Huma	1998
Depression and anxiety in heroin addicts: a placebo-controlled study of doxepin in combination with methadone. The American journal of psychiatry, 1975, Volume: 132, Issue:4 Topics: Administration, Oral; Adult; Alcoholic Intoxication; Amphetamine; Anxiety; Barbiturates; Capsules; C	1975

Article	Year
Frontal Lobe Functions, Demoralization, Depression and Craving as Prognostic Factors and Positive Outcomes of Patients with Heroin Use Disorder Receiving 6 Months of Methadone Maintenance Treatment. International journal of environmental research and public health, 2022, 03-20, Volume: 19, Issue:6 Topics: Craving; Demoralization; Depression; Female; Frontal Lobe; Heroin; Heroin Dependence; Humans; Male;	2022
Exploring potential moderators of depressive symptoms and treatment outcomes among patients with opioid use disorder. Addictive behaviors, 2023, Volume: 140 Topics: Analgesics, Opioid; Buprenorphine; Depression; Humans; Methadone; Opiate Substitution Treatment; Opi	2023
Multi-level predictors of psychological problems among methadone maintenance treatment patients in difference types of settings in Vietnam. Substance abuse treatment, prevention, and policy, 2019, 09-18, Volume: 14, Issue:1 Topics: Adult; Anxiety; Comorbidity; Cross-Sectional Studies; Depression; Humans; Male; Methadone; Middle Ag	2019
Challenges of methadone maintenance treatment during the COVID-19 epidemic in China: Policy and service recommendations. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2020, Volume: 35 Topics: Ambulatory Care; Analgesics, Opioid; Anxiety; China; Coronavirus Infections; COVID-19; Delivery of H	2020
Depression Disorders in Patients with Chronic Hepatitis C. Psychiatria Danubina, 2020, Volume: 32, Issue:Suppl 4 Topics: Antiviral Agents; Bosnia and Herzegovina; Buprenorphine; Depression; Drug Therapy, Combination; Fema	2020
Effects of treatment status and life quality on anxiety in MMT patients. Substance abuse treatment, prevention, and policy, 2021, 01-13, Volume: 16, Issue:1 Topics: Anxiety; China; Depression; Humans; Methadone; Opiate Substitution Treatment; Quality of Life	2021
Comparison Between Urinalysis Results and Self-Reported Heroin Use Among Patients Undergoing Methadone Maintenance Treatment in China. Substance use & misuse, 2017, 08-24, Volume: 52, Issue:10 Topics: Adult; China; Depression; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Morphine;	2017
Constipation and other common symptoms reported by women and men in methadone and buprenorphine maintenance treatment. Drug and alcohol dependence, 2017, 12-01, Volume: 181 Topics: Adult; Analgesics, Opioid; Australia; Buprenorphine; Case-Control Studies; Constipation; Depression;	2017
Plasma Testosterone and Sexual Function in Southeast Asian Men Receiving Methadone and Buprenorphine Maintenance Treatment. The journal of sexual medicine, 2018, Volume: 15, Issue:2 Topics: Adult; Analgesics, Opioid; Buprenorphine; Depression; Female; Humans; Hypogonadism; Male; Methadone;	2018
The relationships between depression, neuroticism, and attitudes (NDA model) in heroin abusers in Taiwan. The American journal on addictions, 2018, Volume: 27, Issue:2 Topics: Adult; Attitude; Behavior, Addictive; Cross-Sectional Studies; Depression; Female; Heroin Dependence	2018
Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment. Neuroscience letters, 2018, 08-10, Volume: 681 Topics: Animals; Anxiety; Depression; Exercise Test; Male; Maze Learning; Methadone; Morphine; Morphine Depe	2018
Non-suicidal self-injury in Chinese heroin-dependent patients receiving methadone maintenance treatment: Prevalence and associated factors. Drug and alcohol dependence, 2018, 08-01, Volume: 189 Topics: Adult; Anxiety; China; Cross-Sectional Studies; Depression; Female; Heroin Dependence; Humans; Lonel	2018
Prefrontal cortex response to drug cues, craving, and current depressive symptoms are associated with treatment outcomes in methadone-maintained patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019, Volume: 44, Issue:4 Topics: Adolescent; Adult; Analgesics, Opioid; Craving; Cues; Depression; Female; Humans; Male; Methadone; O	2019
Interrelationship of Opioid Dependence, Impaired Impulse Control, and Depressive Symptoms: An Open-Label Cross-Sectional Study of Patients in Maintenance Therapy. Neuropsychobiology, 2019, Volume: 77, Issue:2 Topics: Adult; Analgesics, Opioid; Buprenorphine; Comorbidity; Cross-Sectional Studies; Depression; Educatio	2019
Mental health and cognitive function responses to quetiapine in patients with methamphetamine abuse under methadone maintenance treatment. Journal of affective disorders, 2019, 05-15, Volume: 251 Topics: Adolescent; Adult; Aged; Amphetamine-Related Disorders; Antidepressive Agents; Cognition; Depression	2019
Insomnia and excessive daytime sleepiness in women and men receiving methadone and buprenorphine maintenance treatment. Substance use & misuse, 2019, Volume: 54, Issue:10 Topics: Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Cross-Sectional Studies; Depression;	2019
Association between Use of Methadone, Other Central Nervous System Depressants, and QTc Interval-Prolonging Medications and Risk of Mortality in a Large Cohort of Women Living with or at Risk for Human Immunodeficiency Virus Infection. Pharmacotherapy, 2019, Volume: 39, Issue:9 Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Benzodiazepines; Cause of Death; CD4 Ly	2019
The N-methyl-D-aspartate receptor antagonist d-methadone acutely improves depressive-like behavior in the forced swim test performance of rats. Experimental and clinical psychopharmacology, 2020, Volume: 28, Issue:2 Topics: Animals; Antidepressive Agents; Depression; Ketamine; Male; Methadone; Rats; Rats, Sprague-Dawley; R	2020
Hypertension, chronic obstructive pulmonary disease, diabetes and depression among older methadone maintenance patients in British Columbia. Drug and alcohol review, 2013, Volume: 32, Issue:4 Topics: British Columbia; Case-Control Studies; Chronic Disease; Depression; Diabetes Mellitus; Drug Utiliza	2013
Correlates of depressive symptoms among alcohol-using methadone maintained adults. The American journal on addictions, 2012, Volume: 21 Suppl 1 Topics: Adult; Alcohol Drinking; Alcohol-Related Disorders; Analgesics, Opioid; Cross-Sectional Studies; Dep	2012
Depression in male patients on methadone maintenance therapy. Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists, 2013, Volume: 5 Suppl 1 Topics: Adult; Cross-Sectional Studies; Depression; Educational Status; Humans; Interview, Psychological; Ma	2013
Hepatitis C virus infection is independently associated with depression among methadone maintenance treatment heroin users in China. Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists, 2013, Volume: 5, Issue:3 Topics: Adult; China; Comorbidity; Depression; Female; Hepatitis C; Humans; Male; Methadone; Middle Aged; Op	2013
Maternal stress and behavioral adaptation in methadone- or buprenorphine-exposed toddlers. Infant behavior & development, 2013, Volume: 36, Issue:4 Topics: Adult; Anxiety; Buprenorphine; Child; Child, Preschool; Depression; Family; Female; Humans; Longitud	2013
Sexual dysfunction improved in heroin-dependent men after methadone maintenance treatment in Tianjin, China. PloS one, 2014, Volume: 9, Issue:2 Topics: Adult; China; Demography; Depression; Heroin Dependence; Humans; Maintenance Chemotherapy; Male; Met	2014
Intimate partner violence among individuals in methadone maintenance treatment. Substance abuse, 2014, Volume: 35, Issue:2 Topics: Adult; Controlled Clinical Trials as Topic; Crime Victims; Depression; Drug Users; Female; Humans; M	2014
The interaction of active substance use, depression, and antiretroviral adherence in methadone maintenance. International journal of behavioral medicine, 2015, Volume: 22, Issue:2 Topics: Adult; Antiretroviral Therapy, Highly Active; Depression; Female; HIV Infections; Humans; Male; Medi	2015
Factors associated with depression and anxiety among patients attending community-based methadone maintenance treatment in China. Addiction (Abingdon, England), 2015, Volume: 110 Suppl 1 Topics: Adult; Analgesics, Opioid; Anxiety; China; Comorbidity; Cross-Sectional Studies; Depression; Drug Us	2015
Familial expressed emotion among heroin addicts in methadone maintenance treatment: does it matter? Addictive behaviors, 2015, Volume: 45 Topics: Adult; Anxiety; Depression; Expressed Emotion; Family; Female; Heroin Dependence; Humans; Male; Medi	2015
Associations between chronic non-cancer pain and medication assisted treatment outcomes for opiate addiction. The American journal on addictions, 2015, Volume: 24, Issue:2 Topics: Adult; Anxiety; Chronic Pain; Comorbidity; Depression; Female; Humans; Kentucky; Male; Methadone; Op	2015
Comparison of outcomes after 3-month methadone maintenance treatment between heroin users with and without HIV infection: a 3-month follow-up study. Harm reduction journal, 2015, May-08, Volume: 12 Topics: Adult; Depression; Female; Follow-Up Studies; Heroin Dependence; HIV Infections; Humans; Male; Metha	2015
Is Internet Addiction Prevalent Among Methadone Maintenance Treatment Patients? Data from Las Vegas and Tel Aviv. Journal of addictive diseases, 2015, Volume: 34, Issue:4 Topics: Adult; Behavior, Addictive; Benzodiazepines; Cross-Sectional Studies; Depression; Female; Humans; In	2015
[Association between negative emotion and interpersonal sensitivity among patients in methadone maintenance treatment]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2015, Volume: 49, Issue:8 Topics: Adult; Anxiety; Depression; Female; Humans; Interpersonal Relations; Male; Methadone; Middle Aged; O	2015
Heroin craving and its correlations with clinical outcome indicators in people with heroin dependence receiving methadone maintenance treatment. Comprehensive psychiatry, 2016, Volume: 65 Topics: Adolescent; Adult; Craving; Depression; Female; Heroin; Heroin Dependence; Humans; Male; Methadone;	2016
Changes in psychological well-being among heroin-dependent adolescents during psychologically supported opiate substitution treatment. Early intervention in psychiatry, 2018, Volume: 12, Issue:3 Topics: Adolescent; Adolescent Behavior; Anger; Anxiety; Buprenorphine; Combined Modality Therapy; Depressio	2018
Elevated methylation and decreased serum concentrations of BDNF in patients in levomethadone compared to diamorphine maintenance treatment. European archives of psychiatry and clinical neuroscience, 2017, Volume: 267, Issue:1 Topics: Adult; Analgesics, Opioid; Brain-Derived Neurotrophic Factor; Case-Control Studies; Depression; Epig	2017
Depression, suicidal ideation, and related factors of methadone maintenance treatment users in Guangzhou, China. AIDS care, 2016, Volume: 28, Issue:7 Topics: Adult; China; Cross-Sectional Studies; Depression; Drug Users; Female; Humans; Interview, Psychologi	2016
Many correlates of poor quality of life among substance users entering treatment are not addiction-specific. Health and quality of life outcomes, 2016, Mar-03, Volume: 14 Topics: Adult; Age Factors; Cohort Studies; Cross-Sectional Studies; Depression; Female; Humans; Male; Metha	2016
Chronic pain, craving, and illicit opioid use among patients receiving opioid agonist therapy. Drug and alcohol dependence, 2016, Sep-01, Volume: 166 Topics: Adult; Analgesics, Opioid; Buprenorphine; Chronic Pain; Craving; Cross-Sectional Studies; Depression	2016
Resilience associated with mental health problems among methadone maintenance treatment patients in Guangzhou, China. AIDS care, 2017, Volume: 29, Issue:5 Topics: Adult; Anxiety; China; Depression; Female; Humans; Male; Mental Health; Methadone; Middle Aged; Opia	2017
Low prefrontal perfusion linked to depression symptoms in methadone-maintained opiate-dependent patients. Drug and alcohol dependence, 2009, Jan-01, Volume: 99, Issue:1-3 Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Cerebrovascular Circulation; Depression; Female; Gyrus	2009
[Study on anxiety and depression status among the methadone maintenance treatment patients in Wuxi, Jiangsu]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2008, Volume: 29, Issue:3 Topics: Anxiety; China; Depression; Female; Heroin Dependence; Humans; Male; Methadone	2008
An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey. British dental journal, 2008, Dec-13, Volume: 205, Issue:11 Topics: Adolescent; Adult; Aggression; Aging; Alcohol Drinking; Amphetamine-Related Disorders; Anxiety; Atte	2008
Correlates of alcohol use among methadone-maintained adults. Drug and alcohol dependence, 2009, Apr-01, Volume: 101, Issue:1-2 Topics: Adolescent; Adult; Age Factors; Alcohol Drinking; Black People; Depression; Ethnicity; Female; Healt	2009
Subjective daytime sleepiness and daytime function in patients on stable methadone maintenance treatment: possible mechanisms. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2008, Dec-15, Volume: 4, Issue:6 Topics: Adult; Australia; Case-Control Studies; Depression; Female; Humans; Male; Methadone; Middle Aged; Na	2008
Health-related quality of life in methadone maintenance patients with untreated hepatitis C virus infection. Drug and alcohol dependence, 2009, May-01, Volume: 101, Issue:3 Topics: Adult; Depression; Ethnicity; Health Status; Hepatitis C; Humans; Mental Health; Methadone; Middle A	2009
Struck from behind: maintaining quality of life with chronic low back pain. The journal of pain, 2009, Volume: 10, Issue:9 Topics: Accidents, Traffic; Activities of Daily Living; Adult; Analgesics, Opioid; Bupropion; Depression; Do	2009
Suicide attempts prior to starting methadone maintenance treatment in Taiwan. Drug and alcohol dependence, 2010, Jun-01, Volume: 109, Issue:1-3 Topics: Adult; Age of Onset; Depression; Family; Female; Heroin Dependence; Humans; Male; Methadone; Narcoti	2010
High rates of sustained virological response in hepatitis C virus-infected injection drug users receiving directly observed therapy with peginterferon alpha-2a (40KD) (PEGASYS) and once-daily ribavirin. Journal of substance abuse treatment, 2010, Volume: 38, Issue:4 Topics: Adult; Antidepressive Agents; Antiviral Agents; Buprenorphine; Citalopram; Depression; Directly Obse	2010
Self-reported side effects in buprenorphine and methadone patients receiving antiretroviral therapy: results from the MANIF 2000 cohort study. Addiction (Abingdon, England), 2010, Volume: 105, Issue:12 Topics: Anti-Retroviral Agents; Attitude to Health; Buprenorphine; Cohort Studies; Depression; Female; Franc	2010
Nicotine dependence and depression among women smokers on methadone maintenance. The European journal of general practice, 2010, Volume: 16, Issue:4 Topics: Adult; Cross-Sectional Studies; Depression; Female; Humans; Linear Models; Methadone; Middle Aged; N	2010
Pain catastrophizing and pain coping among methadone-maintained patients. Pain medicine (Malden, Mass.), 2011, Volume: 12, Issue:1 Topics: Adaptation, Psychological; Adult; Catastrophization; Depression; Disability Evaluation; Employment;	2011
Clinician-assessed depression and HAART adherence in HIV-infected individuals in methadone maintenance treatment. Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2011, Volume: 42, Issue:1 Topics: Antiretroviral Therapy, Highly Active; Depression; Female; HIV Infections; Humans; Male; Medication	2011
Quality of life and its correlates among heroin users in Taiwan. The Kaohsiung journal of medical sciences, 2011, Volume: 27, Issue:5 Topics: Adolescent; Adult; Case-Control Studies; Depression; Family; Female; Heroin Dependence; Humans; Male	2011
Predictors of the severity of depressive symptoms among intravenous heroin users receiving methadone maintenance treatment in Taiwan: an 18-month follow-up study. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2012, Volume: 26, Issue:1 Topics: Adolescent; Adult; Depression; Female; Follow-Up Studies; Heroin Dependence; HIV Seropositivity; Hum	2012
[Differences in depression severity and frequency of relapses in opiate addicts treated with methadone or opiate blocker after detoxification]. Vojnosanitetski pregled, 2012, Volume: 69, Issue:4 Topics: Adult; Depression; Humans; Male; Methadone; Middle Aged; Naltrexone; Narcotic Antagonists; Opiate Su	2012
Depression, Testosterone concentration, sexual dysfunction and methadone use among men with hypogonadism and HIV Infection. AIDS and behavior, 2012, Volume: 16, Issue:8 Topics: Adult; Cross-Sectional Studies; Depression; Female; HIV Infections; Humans; Hypogonadism; Iran; Logi	2012
Can heroin-dependent individuals benefit from a methadone maintenance treatment program before they drop out against medical advice? A 12-month follow-up study. European addiction research, 2013, Volume: 19, Issue:3 Topics: Adult; Depression; Diagnosis, Dual (Psychiatry); Female; Follow-Up Studies; Heroin Dependence; Human	2013
Predictors for dropping-out from methadone maintenance therapy programs among heroin users in southern Taiwan. Substance use & misuse, 2013, Volume: 48, Issue:1-2 Topics: Adult; Attitude to Health; Depression; Drug Costs; Female; Heroin Dependence; Humans; Male; Methadon	2013
Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups. Hepatology (Baltimore, Md.), 2003, Volume: 37, Issue:2 Topics: Adult; Alcohol Drinking; Antidepressive Agents; Antiviral Agents; Depression; Female; Hepatitis C, C	2003
The depression of respiration by the opiates and its antagonism by nalorphine. Proceedings of the Royal Society of Medicine, 1953, Volume: 46, Issue:11 Topics: Analgesics, Opioid; Depression; Depressive Disorder; Humans; Meperidine; Methadone; Morphine; Nalorp	1953
Controlled respiration by central depression. Anaesthesia, 1958, Volume: 13, Issue:1 Topics: Anesthesia; Anesthesiology; Depression; Humans; Methadone; Respiration, Artificial	1958
[Semiquantitative determination of physical dependence in morphine and methadon therapy]. Archiv fur Psychiatrie und Nervenkrankheiten, vereinigt mit Zeitschrift fur die gesamte Neurologie und Psychiatrie, 1959, Volume: 199, Issue:1 Topics: Depression; Depressive Disorder; Humans; Methadone; Morphine; Morphine Dependence; Substance-Related	1959
[CONTROLLABLE APNEA IN ANESTHESIA BY MEANS OF CENTRAL DEPRESSION DUE TO ANALGESICS]. Gazzetta internazionale di medicina e chirurgia, 1964, Nov-30, Volume: 68 Topics: Analgesics; Anesthesia; Apnea; Central Nervous System Agents; Depression; Dextromoramide; Humans; Me	1964
[Health related quality of life among HIV-HCV co-infected patients]. Revue d'epidemiologie et de sante publique, 2006, Volume: 54 Spec No 1 Topics: Adult; Anti-Retroviral Agents; Buprenorphine; Cohort Studies; Counseling; Data Interpretation, Stati	2006
Self-medication hypothesis of substance use: testing Khantzian's updated theory. Journal of psychoactive drugs, 2007, Volume: 39, Issue:2 Topics: Adult; Affect; Affective Symptoms; Anxiety; Behavior, Addictive; Depression; Female; Hostility; Huma	2007
Exploring the prevalence of menopause symptoms in midlife women in methadone maintenance treatment. Social work in health care, 2007, Volume: 45, Issue:4 Topics: Adult; Chi-Square Distribution; Cross-Sectional Studies; Depression; Female; Health Surveys; HIV Inf	2007
Erectile dysfunction in male heroin users, receiving methadone and buprenorphine maintenance treatment. Drug and alcohol dependence, 2008, Apr-01, Volume: 94, Issue:1-3 Topics: Adolescent; Adult; Buprenorphine; Depression; Erectile Dysfunction; Heroin Dependence; Humans; Male;	2008
Erectile dysfunction in men receiving methadone and buprenorphine maintenance treatment. The journal of sexual medicine, 2008, Volume: 5, Issue:3 Topics: Adult; Age Factors; Buprenorphine; Depression; Dose-Response Relationship, Drug; Erectile Dysfunctio	2008
Receptor physiology and hormone secretion in affective illness. Psychopharmacology bulletin, 1983, Volume: 19, Issue:3 Topics: Acetylcholine; Antidepressive Agents; Biogenic Amines; Blood Platelets; Depression; Humans; Methadon	1983
Methadone, monoamine oxidase, and depression: opioid distribution and acute effects on enzyme activity. Biological psychiatry, 1983, Volume: 18, Issue:9 Topics: Animals; Depression; Humans; Hypothalamus; Limbic System; Liver; Male; Methadone; Monoamine Oxidase;	1983
Depression during methadone withdrawal: no role for beta-phenylethylamine. Drug and alcohol dependence, 1984, Volume: 13, Issue:1 Topics: 2-Hydroxyphenethylamine; Adult; Depression; Female; Humans; Liver Function Tests; Male; Methadone; M	1984
Symptoms discriminating between heroin addicts seeking ambulatory detoxification or methadone maintenance. Drug and alcohol dependence, 1982, Volume: 9, Issue:4 Topics: Adult; Depression; Heroin Dependence; Humans; Interpersonal Relations; Methadone; Psychiatric Status	1982
Sudden onset of stuttering: a case report. The Journal of speech and hearing disorders, 1982, Volume: 47, Issue:3 Topics: Adult; Depression; Feedback; Heroin Dependence; Humans; Male; Methadone; Stuttering; Suicide, Attemp	1982
Stressful life events and the return to heroin use. Journal of human stress, 1981, Volume: 7, Issue:2 Topics: Depression; Heroin Dependence; Humans; Life Change Events; Methadone; Recurrence	1981
Affect dimensions of male heroin addicts admitted for inpatient detoxification. The International journal of the addictions, 1981, Volume: 16, Issue:2 Topics: Adult; Affect; Anger; Confusion; Depression; Fatigue; Heroin Dependence; Humans; Male; Methadone	1981
A study of SCL-90 scores of 264 methadone patients in treatment. The International journal of the addictions, 1981, Volume: 16, Issue:3 Topics: Affective Symptoms; Depression; Female; Heroin Dependence; Humans; Male; Methadone; Psychiatric Stat	1981
Supression of plasma cortisol in depressed patients by acute intravenous methadone infusion. The American journal of psychiatry, 1980, Volume: 137, Issue:7 Topics: Depression; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Infusions, Parenteral; Methadone	1980
Clinical effects of beta-endorphin infusions. Advances in biochemical psychopharmacology, 1980, Volume: 22 Topics: Adult; Behavior; Depression; Double-Blind Method; Endorphins; Female; Heart Rate; Hemodynamics; Huma	1980
The relationship of mean daily blood alcohol levels to admission MAST, clinic absenteeism and depression in alcoholic methadone patients. Drug and alcohol dependence, 1993, Volume: 32, Issue:2 Topics: Adult; Alcoholism; Breath Tests; Comorbidity; Depression; Ethanol; Female; Humans; Male; Methadone;	1993
Nicotine dependence and depression among methadone maintenance patients. Journal of the National Medical Association, 1996, Volume: 88, Issue:12 Topics: Adult; Aged; Depression; Female; Humans; Logistic Models; Male; Methadone; Middle Aged; Nicotine; Od	1996
Treatment failure and methadone dose in a public methadone maintenance treatment programme in Geneva. Drug and alcohol dependence, 1998, May-01, Volume: 50, Issue:3 Topics: Adult; Chi-Square Distribution; Cohort Effect; Confidence Intervals; Depression; Female; Follow-Up S	1998
Effects of "binge" use of intravenous cocaine in methadone-maintained individuals. Addiction (Abingdon, England), 1998, Volume: 93, Issue:6 Topics: Adult; Affect; Blood Pressure; Cocaine; Cocaine-Related Disorders; Depression; Heart Rate; Humans; I	1998
Relationship of HIV testing and high-risk behaviors among clients in methadone maintenance treatment. AIDS education and prevention : official publication of the International Society for AIDS Education, 1998, Volume: 10, Issue:5 Topics: Adult; Data Interpretation, Statistical; Depression; Female; Heroin Dependence; HIV Infections; HIV	1998
Sleep-disordered breathing in stable methadone programme patients: a pilot study. Addiction (Abingdon, England), 2001, Volume: 96, Issue:3 Topics: Adult; Body Mass Index; Case-Control Studies; Depression; Female; Health Status; Heroin Dependence;	2001
The physiological interrelationships between depression, drugs, and sexuality. Nursing forum, 1978, Volume: 17, Issue:2 Topics: Antihypertensive Agents; Anxiety; Cannabis; Contraceptives, Oral; Depression; Ethanol; Female; Genit	1978
Development of psychiatric illness in drug abusers. Possible role of drug preference. The New England journal of medicine, 1979, Dec-13, Volume: 301, Issue:24 Topics: Adult; Amphetamines; Anti-Anxiety Agents; Barbiturates; Benzodiazepines; Depression; Hallucinogens;	1979
Cyclic AMP in cerebrospinal fluid of manic and depressive patients. Psychological medicine, 1977, Volume: 7, Issue:4 Topics: Administration, Oral; Amitriptyline; Bipolar Disorder; Cyclic AMP; Depression; Humans; Imipramine; L	1977
Psychosocial stressors and depression among former heroin dependent patients maintained on methadone. The Journal of nervous and mental disease, 1977, Volume: 165, Issue:1 Topics: Adult; Cross-Sectional Studies; Depression; Female; Heroin Dependence; Humans; Life Change Events; M	1977
Chronic pain: a management plan based on experiences in a pain clinic. Postgraduate medicine, 1979, Volume: 66, Issue:4 Topics: Behavior Therapy; Carbamazepine; Chronic Disease; Depression; Electric Stimulation Therapy; Humans;	1979
Rapid opiate detoxification: clinical evidence of antidepressant and antipanic effects of opiates. The American journal of psychiatry, 1979, Volume: 136, Issue:7 Topics: Adult; Anxiety; Clonidine; Depression; Drug Therapy, Combination; Fear; Humans; Imipramine; Male; Me	1979
Narcotics and monoamine oxidase-inhibitors. The Medical journal of Australia, 1979, May-05, Volume: 1, Issue:9 Topics: Adult; Depression; Drug Interactions; Humans; Male; Methadone; Substance-Related Disorders; Tranylcy	1979
Mood components of heroin addicted men: psychosocial correlates. The International journal of the addictions, 1979, Volume: 14, Issue:8 Topics: Adult; Affect; Anger; Confusion; Depression; Fatigue; Heroin Dependence; Hostility; Humans; Male; Me	1979
Depression in treated narcotic addicts, ex-addicts, nonaddicts, and suicide attempters: validation of a very Brief Depression Scale. The American journal of drug and alcohol abuse, 1979, Volume: 6, Issue:4 Topics: Depression; Dextropropoxyphene; Double-Blind Method; Ethnicity; Heroin Dependence; Humans; Male; Met	1979
Abuse of amitriptyline. JAMA, 1978, Sep-22, Volume: 240, Issue:13 Topics: Amitriptyline; Depression; Heroin Dependence; Humans; Methadone; Self Medication; Substance Withdraw	1978
Psychotropic drugs in opioid addicts on methadone treatment. Diseases of the nervous system, 1976, Volume: 37, Issue:7 Topics: Adult; Anxiety; Depression; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Male; Meth	1976
Psychopathology, craving, and mood during heroin acquisition: an experimental study. The International journal of the addictions, 1976, Volume: 11, Issue:3 Topics: Adult; Aggression; Anxiety; Depression; Drive; Emotions; Heroin; Heroin Dependence; Hostility; Human	1976
Clinical depression among narcotic addicts maintained on methadone in the community. The American journal of psychiatry, 1976, Volume: 133, Issue:12 Topics: Adult; Alcoholism; Community Mental Health Services; Depression; Heroin Dependence; Humans; Life Cha	1976
Metabolic disposition of 2-phenylethylamine and the role of depression in methadone-dependent and detoxified patients. Drug and alcohol dependence, 1976, Volume: 1, Issue:4 Topics: Adult; Depression; Female; Heroin Dependence; Humans; Male; Methadone; Phenethylamines; Substance Wi	1976
Problem drinkers among patients on methadone. The American journal of drug and alcohol abuse, 1975, Volume: 2, Issue:2 Topics: Adult; Alcoholic Intoxication; Alcoholism; Aspartate Aminotransferases; Depression; Female; Hepatome	1975
Early treatment time course of depressive symptoms in opiate addicts. The Journal of nervous and mental disease, 1991, Volume: 179, Issue:4 Topics: Adult; Black or African American; Depression; Depressive Disorder; Female; Follow-Up Studies; Humans	1991
HIV-infected i.v. drug users in methadone treatment: outcome and psychological correlates--a preliminary report. NIDA research monograph, 1989, Volume: 95 Topics: Adult; Cocaine; Depression; Female; Heroin Dependence; HIV Infections; Humans; Male; Methadone; Risk	1989
Depression in opioid users varies with substance use status. The American journal of drug and alcohol abuse, 1987, Volume: 13, Issue:4 Topics: Adult; Aged; Alcoholism; Depression; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Di	1987
Psychological adjustment--mood and personality fluctuations of long-term methadone maintenance patients. The International journal of the addictions, 1972, Volume: 7, Issue:4 Topics: Adult; Anxiety; Counseling; Depression; Evaluation Studies as Topic; Female; Hawaii; Heroin; Hostili	1972
Cerebrospinal fluid amine metabolites in affective illness: the probenecid technique. The American journal of psychiatry, 1973, Volume: 130, Issue:1 Topics: Affective Symptoms; Biological Transport, Active; Bipolar Disorder; Brain; Brain Chemistry; Depressi	1973
The significance of diagnosis in the treatment of narcotics addicts. The International journal of the addictions, 1970, Volume: 5, Issue:4 Topics: Adult; Anxiety; Community Health Services; Depression; Evaluation Studies as Topic; Heroin; Humans;	1970
Some descriptive measures on 100 consecutive VA hospital drug abuse admissions. The International journal of the addictions, 1974, Volume: 9, Issue:3 Topics: Adolescent; Adult; Amphetamine; Antisocial Personality Disorder; Anxiety; Barbiturates; Depression;	1974
Self-destructive aspects of hard core addiction. Archives of general psychiatry, 1973, Volume: 28, Issue:4 Topics: Adolescent; Adult; Attitude; Black or African American; Death; Depression; District of Columbia; Fem	1973
Dropouts from treatment. Canadian Psychiatric Association journal, 1973, Volume: 18, Issue:3 Topics: Alcoholism; Appointments and Schedules; Attitude of Health Personnel; Attitude to Health; Cooperativ	1973
Internal indicators for the management and prognosis of patients in a methadone maintenance program (internal states self-report scale). Proceedings. National Conference on Methadone Treatment, 1973, Volume: 1 Topics: Adult; Anxiety; Depression; Female; Heroin Dependence; Humans; Male; Methadone; Personality Assessme	1973
Depression and self-concept as variables in the differential response to methadone maintenance combined with therapy. Proceedings. National Conference on Methadone Treatment, 1973, Volume: 1 Topics: Adult; Depression; Female; Heroin Dependence; Humans; Male; Methadone; Patient Dropouts; Personality	1973
Methadone pseudowithdrawal: etiological considerations. Proceedings. National Conference on Methadone Treatment, 1973, Volume: 1 Topics: Anxiety; Depression; Diagnosis, Differential; Heroin Dependence; Humans; Methadone; Substance Withdr	1973
Issues for the therapist working towards improved social functioning of the methadone maintained client. Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2 Topics: Attitude of Health Personnel; Depression; Female; Heroin Dependence; Humans; Life Style; Male; Metha	1973
A comparison of level of anxiety, depression and hostility with methadone plasma concentration in opioid-dependent patients receiving methadone on a maintenance dosage schedule. Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2 Topics: Anxiety; Community Health Services; Depression; Female; Heroin Dependence; Hostility; Humans; Male;	1973
Methadone dose and emotional states in drug-addicted patients. Journal of clinical psychology, 1974, Volume: 30, Issue:3 Topics: Adult; Affective Symptoms; Anxiety; Depression; Dose-Response Relationship, Drug; Heroin Dependence;	1974
Personality correlates of success in a methadone maintenance program. The American journal of psychiatry, 1972, Volume: 129, Issue:4 Topics: Adult; Anxiety; Black or African American; Community Health Services; Cooperative Behavior; Counseli	1972

methadone and Depression

Research Excerpts

Research

Studies (144)

Authors

Clinical Trials (10)

Trial Overview

Trial Outcomes

Carbon Monoxide (CO)-Confirmed 7-day Abstinence

Change in Cigarettes Per Day

Change in Smoking Urges

CO-confirmed 7-day Abstinence

Rates of Smoking Cessation Continuous From First Quit Day to 6 Months

Reinforcing Effects of Smoking

Self- Reported 7-day Abstinence

Self-reported 7-day Abstinence

Withdrawal Symptoms

Child's Head Circumference Measurement (Measured at Birth)

Child's Length of Hospital Stay

Child's Peak Daily Total NAS Score

Mother's HIV Risk Behaviors (Measured Monthly by Risk Behavior Assessment)

Mother's Measures of Dose Adequacy and Acceptance Over Time (Measured Weekly by Dose Adequacy Measure)

Mother's Psychosocial Functioning at Delivery as Measured by the Addiction Severity Index Psychosocial Index Score

Mother's Self-report of Drug Use (Measured Monthly by Time Line Follow Back)

Number of Children Requiring Treatment for Neonatal Abstinence Signs (NAS)

Total Amount of Morphine Sulfate That a Neonate Receives to Treat NAS

Reviews

Trials

Other Studies