methadone has been researched along with Depression, Involutional in 29 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Depression, Involutional: Form of depression in those MIDDLE AGE with feelings of ANXIETY.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, the aim of this study was to examine the efficacy of antidepressants in patients with unipolar major depressive disorder (MDD) and/or dysthymic disorder (DD) with comorbid opiate-use disorders currently in methadone maintenance treatment (MMT)." | 8.87 | Treatment of major depressive disorder and dysthymic disorder with antidepressants in patients with comorbid opiate use disorders enrolled in methadone maintenance therapy: a meta-analysis. ( Bentley, KH; Iovieno, N; Papakostas, GI; Pedrelli, P; Tedeschini, E; Vitali, M, 2011) |
| " The objective of this study was to examine the prevalence and correlates of suicide attempt in Chinese individuals receiving methadone maintenance treatment for heroin dependence." | 7.91 | Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence. ( Chen, H; Lu, J; Xie, WX; Zhong, BL; Zhu, JH, 2019) |
| " Factors associated with recent suicide attempts were: being an RR entrant, female gender, younger age, less education, more extensive polydrug use, benzodiazepine use, recent heroin overdose, Major Depression, current suicidal ideation, Borderline Personality Disorder (BPD)and Post-Traumatic Stress Disorder." | 7.72 | Attempted suicide among entrants to three treatment modalities for heroin dependence in the Australian Treatment Outcome Study (ATOS): prevalence and risk factors. ( Darke, S; Lynskey, M; Ross, J; Teesson, M, 2004) |
| " Therefore, the aim of this study was to examine the efficacy of antidepressants in patients with unipolar major depressive disorder (MDD) and/or dysthymic disorder (DD) with comorbid opiate-use disorders currently in methadone maintenance treatment (MMT)." | 4.87 | Treatment of major depressive disorder and dysthymic disorder with antidepressants in patients with comorbid opiate use disorders enrolled in methadone maintenance therapy: a meta-analysis. ( Bentley, KH; Iovieno, N; Papakostas, GI; Pedrelli, P; Tedeschini, E; Vitali, M, 2011) |
| " The objective of this study was to examine the prevalence and correlates of suicide attempt in Chinese individuals receiving methadone maintenance treatment for heroin dependence." | 3.91 | Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence. ( Chen, H; Lu, J; Xie, WX; Zhong, BL; Zhu, JH, 2019) |
| "The study aimed to determine patterns of major depression (MD) across 36 months, and the relationship to outcomes for the treatment of heroin dependence." | 3.75 | Patterns of major depression and drug-related problems amongst heroin users across 36 months. ( Darke, S; Havard, A; Mills, K; Ross, J; Teesson, M; Williamson, A, 2009) |
| " Factors associated with recent suicide attempts were: being an RR entrant, female gender, younger age, less education, more extensive polydrug use, benzodiazepine use, recent heroin overdose, Major Depression, current suicidal ideation, Borderline Personality Disorder (BPD)and Post-Traumatic Stress Disorder." | 3.72 | Attempted suicide among entrants to three treatment modalities for heroin dependence in the Australian Treatment Outcome Study (ATOS): prevalence and risk factors. ( Darke, S; Lynskey, M; Ross, J; Teesson, M, 2004) |
| "Individuals treated for opioid use disorder (OUD) have high rates of psychiatric disorders potentially diminishing treatment outcomes." | 3.01 | Psychiatric comorbidity and treatment outcomes in patients with opioid use disorder: Results from a multisite trial of buprenorphine-naloxone and methadone. ( Curtis, ME; Evans, EA; Hser, YI; Kelleghan, A; Mooney, LJ; Saxon, AJ; Yoo, C; Zhu, Y, 2021) |
| "HRQOL in opioid dependence improved significantly (p < ." | 2.76 | Quality of life profiles and changes in the course of maintenance treatment among 1,015 patients with severe opioid dependence. ( Haasen, C; Karow, A; Krausz, M; Pukrop, R; Reimer, J; Schäfer, I; Verthein, U, 2011) |
| "The prevalence of major depressive disorder, generalized anxiety disorder and PTSD, respectively, was 10." | 1.62 | Validation of screening tools for common mental health disorders in the methadone maintenance population in Hanoi, Vietnam. ( Bui, Q; Gaynes, BN; Go, V; Ha, TV; Mughal, AY; Pence, BW; Stockton, MA, 2021) |
| "The burden of opiate dependence not only relies on somatic complications such as infectious diseases or acute intoxication but also on frequent psychiatric events such as major depressive disorder (MDD) and suicidal behavior (SB)." | 1.42 | A cannabinoid receptor 1 polymorphism is protective against major depressive disorder in methadone-maintained outpatients. ( Bellivier, F; Bloch, V; Hajj, A; Icick, R; Karsinti, E; Ksouda, K; Laplanche, JL; Lépine, JP; Mouly, S; Peoc'h, K; Prince, N; Vorspan, F, 2015) |
| "In this study, 28." | 1.42 | Psychiatric comorbidities among Iranian elderly patients on methadone maintenance treatment. ( Malakouti, SK; Mohammad, K; Mortazavi, SS; Shati, M, 2015) |
| "Compared to MMT, TC participants had poorer family support, higher rate of unmarried, higher rate of unemployment, earlier onset of heroin use, longer length of heroin use, and lower daily dosage of heron." | 1.42 | Comparison of socio-demographic characteristics, substance, and depression among male heroin users attending therapeutic community and methadone maintenance treatment program in Nantou, Taiwan. ( Chen, VC; Gossop, M; Ho, YF; Lin, TY; Wang, HY; Wu, MH, 2015) |
| " Seventeen methadone patients (7 depressed and 10 not depressed) had pharmacokinetic and pharmacodynamic assessments (opioid withdrawal, drug effects, and mood) over one 24-hour dosing interval." | 1.35 | Major depressive disorder and patient satisfaction in relation to methadone pharmacokinetics and pharmacodynamics in stabilized methadone maintenance patients. ( Brands, B; Dunn, E; Elkader, AK; Selby, P; Sproule, BA, 2009) |
| "We assess the influence of co-occurring psychiatric disorders on retention in 189 opioid dependent patients in a methadone maintenance treatment (MMT) and determine the incidence of psychiatric co-morbidity during an 18-month follow-up period." | 1.35 | Impact of co-occurring psychiatric disorders on retention in a methadone maintenance program: an 18-month follow-up study. ( Astals, M; Bulbena, A; Díaz, L; Domingo-Salvany, A; Martín-Santos, R; Torrens, M, 2009) |
| "Amongst people on opioid maintenance treatment (OMT), chronic hepatitis C (HCV) is common but infrequently treated." | 1.34 | Hazardous alcohol consumption and other barriers to antiviral treatment among hepatitis C positive people receiving opioid maintenance treatment. ( Conigrave, KM; Haber, PS; Wallace, C; Watson, B; Whitfield, JB; Wurst, F, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (58.62) | 29.6817 |
| 2010's | 8 (27.59) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, Y | 1 |
| Mooney, LJ | 1 |
| Yoo, C | 1 |
| Evans, EA | 1 |
| Kelleghan, A | 1 |
| Saxon, AJ | 1 |
| Curtis, ME | 1 |
| Hser, YI | 1 |
| Mughal, AY | 1 |
| Stockton, MA | 1 |
| Bui, Q | 1 |
| Go, V | 1 |
| Ha, TV | 1 |
| Pence, BW | 1 |
| Gaynes, BN | 1 |
| Zhong, BL | 1 |
| Xie, WX | 1 |
| Zhu, JH | 1 |
| Lu, J | 1 |
| Chen, H | 1 |
| Tsai, TY | 1 |
| Wang, TY | 1 |
| Liu, YC | 1 |
| Lee, PW | 1 |
| Chang, WH | 1 |
| Lu, TH | 1 |
| Tseng, HH | 1 |
| Lee, SY | 1 |
| Chang, YH | 1 |
| Yang, Y | 1 |
| Chen, PS | 1 |
| Chen, KC | 1 |
| Yang, YK | 1 |
| Lu, RB | 1 |
| El Hage, C | 1 |
| Ghabrash, MF | 1 |
| Dubreucq, S | 1 |
| Brissette, S | 1 |
| Lespérance, F | 1 |
| Lespérance, P | 1 |
| Ouellet-Plamondon, C | 1 |
| Bruneau, J | 1 |
| Jutras-Aswad, D | 1 |
| Icick, R | 1 |
| Peoc'h, K | 1 |
| Karsinti, E | 1 |
| Ksouda, K | 1 |
| Hajj, A | 1 |
| Bloch, V | 1 |
| Prince, N | 1 |
| Mouly, S | 1 |
| Bellivier, F | 1 |
| Lépine, JP | 1 |
| Laplanche, JL | 1 |
| Vorspan, F | 1 |
| Mortazavi, SS | 1 |
| Shati, M | 1 |
| Malakouti, SK | 1 |
| Mohammad, K | 1 |
| Chen, VC | 1 |
| Wu, MH | 1 |
| Lin, TY | 1 |
| Ho, YF | 1 |
| Wang, HY | 1 |
| Gossop, M | 1 |
| Rosen, D | 1 |
| Smith, ML | 1 |
| Reynolds, CF | 1 |
| Carpenter, KM | 1 |
| Smith, JL | 1 |
| Aharonovich, E | 1 |
| Nunes, EV | 1 |
| Elkader, AK | 1 |
| Brands, B | 1 |
| Dunn, E | 1 |
| Selby, P | 1 |
| Sproule, BA | 1 |
| Shprecher, DR | 1 |
| Flanigan, KM | 1 |
| Smith, AG | 1 |
| Smith, SM | 1 |
| Schenkenberg, T | 1 |
| Steffens, J | 1 |
| Darke, S | 5 |
| Mills, K | 1 |
| Teesson, M | 5 |
| Ross, J | 5 |
| Williamson, A | 1 |
| Havard, A | 2 |
| Astals, M | 1 |
| Díaz, L | 1 |
| Domingo-Salvany, A | 1 |
| Martín-Santos, R | 1 |
| Bulbena, A | 1 |
| Torrens, M | 1 |
| Trujols, J | 1 |
| Siñol, N | 1 |
| de los Cobos, JP | 1 |
| Karow, A | 1 |
| Verthein, U | 1 |
| Pukrop, R | 1 |
| Reimer, J | 1 |
| Haasen, C | 1 |
| Krausz, M | 1 |
| Schäfer, I | 1 |
| Pedrelli, P | 1 |
| Iovieno, N | 1 |
| Vitali, M | 1 |
| Tedeschini, E | 1 |
| Bentley, KH | 1 |
| Papakostas, GI | 1 |
| Lynskey, M | 3 |
| Hetherington, K | 1 |
| Ali, R | 1 |
| Ritter, A | 1 |
| Cooke, R | 1 |
| Kang, SY | 1 |
| Magura, S | 1 |
| Blankertz, L | 1 |
| Madison, E | 1 |
| Spinelli, M | 1 |
| Rachid, F | 1 |
| Golaz, J | 1 |
| Bondolfi, G | 1 |
| Bertschy, G | 1 |
| Stein, MD | 2 |
| Weinstock, MC | 1 |
| Anderson, BJ | 1 |
| Anthony, JL | 1 |
| Watson, B | 1 |
| Conigrave, KM | 1 |
| Wallace, C | 1 |
| Whitfield, JB | 1 |
| Wurst, F | 1 |
| Haber, PS | 1 |
| Abernethy, AP | 1 |
| Nixon, A | 1 |
| Fine, PG | 1 |
| Peppin, JF | 1 |
| Crossno, RJ | 1 |
| Bull, J | 1 |
| Brienza, RS | 1 |
| Chen, M | 1 |
| Gogineni, A | 1 |
| Sobota, M | 1 |
| Maksad, J | 1 |
| Hu, P | 1 |
| Clarke, J | 1 |
| Avants, SK | 1 |
| Warburton, LA | 1 |
| Margolin, A | 1 |
| Bound, D | 1 |
| Greer, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Repetitive Transcranial Magnetic Stimulation in Patients With Opioid Use Disorders: Analysis of Clinical Outcomes, Functional Magnetic Resonance Imaging, Biomarkers, and Neuropsychological Tests[NCT03229642] | 60 participants (Anticipated) | Interventional | 2017-08-01 | Recruiting | |||
| An Open-Label Pilot Study of Desvenlafaxine for Opioid-Dependent Patients With Comorbid Depression[NCT02200406] | Phase 4 | 18 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Factors Associated With the Variance of Oral Methadone Dosage at Steady State of Maintenance Treatment: Description of Bio-markers of Phenotype and Genotype.[NCT00894452] | 210 participants (Actual) | Observational | 2008-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for methadone and Depression, Involutional
| Article | Year |
|---|---|
Treatment of major depressive disorder and dysthymic disorder with antidepressants in patients with comorbid opiate use disorders enrolled in methadone maintenance therapy: a meta-analysis.
Topics: Antidepressive Agents; Depressive Disorder, Major; Diagnosis, Dual (Psychiatry); Dysthymic Disorder; | 2011 |
Palliative care pharmacotherapy literature summaries and analyses.
Topics: Analgesics, Opioid; Cardiovascular Diseases; Clinical Trials as Topic; Cyclooxygenase 2 Inhibitors; | 2007 |
6 trials available for methadone and Depression, Involutional
| Article | Year |
|---|---|
Psychiatric comorbidity and treatment outcomes in patients with opioid use disorder: Results from a multisite trial of buprenorphine-naloxone and methadone.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Comorbidity; Depressive | 2021 |
Add-on repetitive transcranial magnetic stimulation in patients with opioid use disorder undergoing methadone maintenance therapy.
Topics: Adult; China; Craving; Depressive Disorder, Major; Female; Heroin Dependence; Humans; Male; Methadon | 2021 |
A pilot, open-label, 8-week study evaluating desvenlafaxine for treatment of major depression in methadone-maintained individuals with opioid use disorder.
Topics: Adult; Antidepressive Agents; Anxiety; Craving; Depressive Disorder, Major; Desvenlafaxine Succinate | 2018 |
Developing therapies for depression in drug dependence: results of a stage 1 therapy study.
Topics: Adult; Analgesics, Opioid; Behavior Therapy; Depressive Disorder, Major; Diagnosis, Dual (Psychiatry | 2008 |
Quality of life profiles and changes in the course of maintenance treatment among 1,015 patients with severe opioid dependence.
Topics: Adult; Depressive Disorder, Major; Female; Health Status; Heroin; Humans; Male; Methadone; Opiate Su | 2011 |
Relationship of depression to smoking outcomes in a methadone-maintained population.
Topics: Administration, Cutaneous; Adolescent; Adult; Depressive Disorder, Major; Diagnostic and Statistical | 2007 |
21 other studies available for methadone and Depression, Involutional
| Article | Year |
|---|---|
Validation of screening tools for common mental health disorders in the methadone maintenance population in Hanoi, Vietnam.
Topics: Cross-Sectional Studies; Depressive Disorder, Major; Humans; Male; Mass Screening; Mental Health; Me | 2021 |
Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence.
Topics: Adult; Antisocial Personality Disorder; Anxiety; China; Depressive Disorder, Major; Female; Heroin; | 2019 |
A cannabinoid receptor 1 polymorphism is protective against major depressive disorder in methadone-maintained outpatients.
Topics: Adult; Alleles; Depressive Disorder, Major; Female; Humans; Male; Methadone; Middle Aged; Opiate Sub | 2015 |
Psychiatric comorbidities among Iranian elderly patients on methadone maintenance treatment.
Topics: Aged; Aged, 80 and over; Comorbidity; Cross-Sectional Studies; Depressive Disorder, Major; Female; H | 2015 |
Comparison of socio-demographic characteristics, substance, and depression among male heroin users attending therapeutic community and methadone maintenance treatment program in Nantou, Taiwan.
Topics: Adult; Comorbidity; Demography; Depressive Disorder, Major; Dysthymic Disorder; Heroin Dependence; H | 2015 |
The prevalence of mental and physical health disorders among older methadone patients.
Topics: Aged; Alcoholism; Anxiety Disorders; Chronic Disease; Comorbidity; Depressive Disorder, Major; Femal | 2008 |
Major depressive disorder and patient satisfaction in relation to methadone pharmacokinetics and pharmacodynamics in stabilized methadone maintenance patients.
Topics: Adult; Depressive Disorder, Major; Diagnosis, Dual (Psychiatry); Female; Humans; Male; Methadone; Na | 2009 |
Clinical and diagnostic features of delayed hypoxic leukoencephalopathy.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Brain; Cocaine; Cognition Disorders; Depressive Disorder | 2008 |
Patterns of major depression and drug-related problems amongst heroin users across 36 months.
Topics: Adolescent; Adult; Buprenorphine; Cohort Studies; Comorbidity; Crime; Depressive Disorder, Major; Dr | 2009 |
Impact of co-occurring psychiatric disorders on retention in a methadone maintenance program: an 18-month follow-up study.
Topics: Adult; Analgesics, Opioid; Antisocial Personality Disorder; Borderline Personality Disorder; Confide | 2009 |
Methadone maintenance treatment: the need to distinguish between holding dose, dose adequacy, satisfaction with methadone as a medication, and satisfaction with treatment.
Topics: Depressive Disorder, Major; Diagnosis, Dual (Psychiatry); Drug Administration Schedule; Humans; Meth | 2010 |
Attempted suicide among entrants to three treatment modalities for heroin dependence in the Australian Treatment Outcome Study (ATOS): prevalence and risk factors.
Topics: Adolescent; Adult; Age Factors; Ambulatory Care; Antisocial Personality Disorder; Borderline Persona | 2004 |
Non-injecting routes of administration among entrants to three treatment modalities for heroin dependence.
Topics: Administration, Inhalation; Adolescent; Adult; Antisocial Personality Disorder; Borderline Personali | 2004 |
The characteristics of heroin users entering treatment: findings from the Australian treatment outcome study (ATOS).
Topics: Adult; Australia; Buprenorphine; Comorbidity; Crime; Demography; Depressive Disorder, Major; Diagnos | 2005 |
Depression among heroin users: 12-Month outcomes from the Australian Treatment Outcome Study (ATOS).
Topics: Adolescent; Adult; Australia; Depressive Disorder, Major; Female; Heroin Dependence; Humans; Longitu | 2006 |
Predictors of engagement in vocational counseling for methadone treatment patients.
Topics: Adult; Counseling; Demography; Depressive Disorder, Major; Employment, Supported; Female; Heroin Dep | 2006 |
Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive | 2006 |
Hazardous alcohol consumption and other barriers to antiviral treatment among hepatitis C positive people receiving opioid maintenance treatment.
Topics: Adolescent; Adult; Alcoholism; Antiviral Agents; Anxiety Disorders; Australia; Buprenorphine; Comorb | 2007 |
Depression among needle exchange program and methadone maintenance clients.
Topics: Adult; Cocaine-Related Disorders; Cohort Studies; Comorbidity; Cross-Sectional Studies; Depressive D | 2000 |
The influence of coping and depression on abstinence from illicit drug use in methadone-maintained patients.
Topics: Adaptation, Psychological; Adult; Depressive Disorder, Major; Female; Follow-Up Studies; Humans; Mal | 2000 |
Psychotic symptoms after dipipanone.
Topics: Analgesics; Depressive Disorder, Major; Female; Hallucinations; Humans; Methadone; Middle Aged; Pipe | 1978 |