methadone has been researched along with Delayed Effects, Prenatal Exposure in 195 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the profile of signs of neonatal abstinence syndrome (NAS) in methadone- versus buprenorphine-exposed infants." | 9.16 | Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates. ( Arria, AM; Badger, GJ; Coyle, MG; Gaalema, DE; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; Scott, TL; Stine, SM, 2012) |
| "Though methadone pharmacotherapy is the treatment of choice for opiate-dependence during pregnancy in the USA, most methadone-exposed neonates develop neonatal abstinence syndrome (NAS)." | 9.12 | Maternal vagal tone change in response to methadone is associated with neonatal abstinence syndrome severity in exposed neonates. ( Dipietro, JA; Elko, A; Jansson, LM; Velez, M, 2007) |
| "Treating opioid-addicted women with methadone in pregnancy increased the number of newborns suffering from neonatal abstinence syndrome (NAS)." | 9.11 | Therapy of the neonatal abstinence syndrome with tincture of opium or morphine drops. ( Birkenfeld, L; Hellmich, M; Herkenrath, P; Langenfeld, S; Müller, C; Theisohn, M, 2005) |
| "To systematically review and meta-analyse studies of neurodevelopmental outcome of children born to mothers prescribed methadone in pregnancy." | 9.01 | Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis. ( Boardman, JP; Chappell, FM; Hamilton, R; Mactier, H; Monnelly, VJ, 2019) |
| "Buprenorphine and methadone are opioid-receptor agonists used as opioid substitution therapy during pregnancy to limit exposure of the fetus to cycles of opioid withdrawal and reduce the risk of infectious comorbidities of illicit opioid use." | 8.90 | Buprenorphine and methadone for opioid addiction during pregnancy. ( Mozurkewich, EL; Rayburn, WF, 2014) |
| "To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS)." | 8.86 | Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis. ( Clarke, M; Cleary, BJ; Donnelly, J; Fahey, T; Gallagher, PJ; Murphy, DJ; Strawbridge, J, 2010) |
| "Methadone is used as a substitute for illicit opioids during pregnancy." | 8.31 | Long-Term Visual and Neurodevelopmental Outcomes in Two Children with Congenital Nystagmus Secondary to Methadone Exposure In utero. ( Accorsi, P; Fazzi, E; Franzoni, A; Galli, J; Loi, E; Micheletti, S; Pansera, L, 2023) |
| "This article aims to describe neonatal outcomes, clinical correlates, and the rate for neonatal abstinence syndrome (NAS) for women on methadone maintenance therapy." | 7.81 | Maternal methadone treatment and neonatal abstinence syndrome. ( Faisal, M; Li, S; Liu, WF; Singh, K, 2015) |
| "To evaluate the effectiveness of methadone for the treatment of neonatal abstinence syndrome when used according to a preexisting clinical pathway." | 7.80 | Effectiveness of a clinical pathway with methadone treatment protocol for treatment of neonatal abstinence syndrome following in utero drug exposure to substances of abuse*. ( Bhatt-Mehta, V; Ng, CM; Schumacher, RE, 2014) |
| "This report, the first description of Italian cases of nystagmus related to use of methadone during pregnancy, underlies the importance of a careful investigation of drug use in pregnancy in cases of unexplained congenital nystagmus." | 7.79 | Congenital nystagmus in two infants born from mothers exposed to methadone during pregnancy. ( Battini, R; Cioni, G; Gamucci, A; Tinelli, F, 2013) |
| "Infants born to drug-misusing mothers prescribed methadone in pregnancy are at risk of a range of visual problems, the underlying causes of which are not clear." | 7.76 | Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy. ( Bradnam, MS; Hamilton, R; MacKinnon, JR; Mactier, H; McGlone, L; Russell, HC, 2010) |
| "Methadone is standard pharmacotherapy for opioid-dependent pregnant women, yet the relationship between maternal methadone dose and neonatal abstinence syndrome (NAS) severity is still unclear." | 7.76 | Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome. ( Choo, RE; Concheiro, M; Elko, A; Gray, TR; Huestis, MA; Jansson, LM; Jones, HE; Williams, E, 2010) |
| "Four hundred and fifty singleton pregnancies of drug-misusing women prescribed substitute methadone in pregnancy." | 7.75 | Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources. ( Dryden, C; Hepburn, M; Mactier, H; Young, D, 2009) |
| " This study compared the acoustic cry characteristics of infants born to mothers maintained on methadone during pregnancy with those of infants not exposed to methadone during pregnancy." | 7.75 | Acoustic cry characteristics of infants exposed to methadone during pregnancy. ( Quick, ZL; Robb, MP; Woodward, LJ, 2009) |
| "The volume of feeds, changes in infant body weight, as well as occurrence of adverse clinical effects in infants withdrawing from methadone were studied during the first month of life." | 7.70 | Hyperphagia in neonates withdrawing from methadone. ( Kastner, B; Martinez, A; Taeusch, HW, 1999) |
| " Maternal opiate dosing has been investigated with conflicting results." | 5.36 | Perinatal risk factors for the neonatal abstinence syndrome in infants born to women on methadone maintenance therapy. ( Cook, CM; Jones, MP; Liu, AJ; Murray, H; Nanan, R, 2010) |
| "Newborns who are prenatally exposed to methadone are at risk for neonatal abstinence syndrome and the associated excess weight loss and poor weight gain." | 5.27 | Randomized Clinical Trial of Standard- Versus High-Calorie Formula for Methadone-Exposed Infants: A Feasibility Study. ( Baker, R; Bogen, DL; Cohlan, B; Hanusa, BH; Medoff-Cooper, B, 2018) |
| "Methadone and buprenorphine are recommended to treat opioid use disorders during pregnancy." | 5.27 | Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes. ( Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Salisbury, AL; Stine, S, 2018) |
| "To compare the profile of signs of neonatal abstinence syndrome (NAS) in methadone- versus buprenorphine-exposed infants." | 5.16 | Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates. ( Arria, AM; Badger, GJ; Coyle, MG; Gaalema, DE; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; Scott, TL; Stine, SM, 2012) |
| "To identify factors that predict the expression of neonatal abstinence syndrome (NAS) in infants exposed to methadone or buprenorphine in utero." | 5.16 | Predicting treatment for neonatal abstinence syndrome in infants born to women maintained on opioid agonist medication. ( Coyle, MG; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; Salisbury, AL; Stine, SM, 2012) |
| "This was a secondary analysis of data collected in a prospective randomized, double-blind, double-dummy, multicenter trial (MOTHER study) that examined the comparative safety and efficacy of methadone and buprenorphine during pregnancy." | 5.15 | Are male neonates more vulnerable to neonatal abstinence syndrome than female neonates? ( Bäwert, A; Coyle, M; Fischer, G; Jagsch, R; Martin, PR; Rohrmeister, K; Unger, A; Winklbaur, B, 2011) |
| "Though methadone pharmacotherapy is the treatment of choice for opiate-dependence during pregnancy in the USA, most methadone-exposed neonates develop neonatal abstinence syndrome (NAS)." | 5.12 | Maternal vagal tone change in response to methadone is associated with neonatal abstinence syndrome severity in exposed neonates. ( Dipietro, JA; Elko, A; Jansson, LM; Velez, M, 2007) |
| "Treating opioid-addicted women with methadone in pregnancy increased the number of newborns suffering from neonatal abstinence syndrome (NAS)." | 5.11 | Therapy of the neonatal abstinence syndrome with tincture of opium or morphine drops. ( Birkenfeld, L; Hellmich, M; Herkenrath, P; Langenfeld, S; Müller, C; Theisohn, M, 2005) |
| "A literature search was conducted using scientific databases (PubMed, Scopus, Web of Science, and reports from international institutions) to review published articles on buprenorphine and methadone monitoring during pregnancy." | 5.05 | Monitoring Prenatal Exposure to Buprenorphine and Methadone. ( Busardò, FP; Carlier, J; Di Trana, A; Huestis, MA; La Maida, N; Pichini, S; Tittarelli, R, 2020) |
| "To systematically review and meta-analyse studies of neurodevelopmental outcome of children born to mothers prescribed methadone in pregnancy." | 5.01 | Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis. ( Boardman, JP; Chappell, FM; Hamilton, R; Mactier, H; Monnelly, VJ, 2019) |
| "Parents of infants with neonatal abstinence syndrome (NAS) in the NICU may have questions about the long-term consequences of prenatal exposure to methadone, both asked and unasked." | 4.93 | Long-Term Outcomes of Infants with Neonatal Abstinence Syndrome. ( Armstrong, K; Brooks, SS; Clark, L; Cline, GJ; Germain, AM; Maguire, DJ; Shaffer-Hudkins, E; Taylor, S, 2016) |
| "Buprenorphine and methadone are opioid-receptor agonists used as opioid substitution therapy during pregnancy to limit exposure of the fetus to cycles of opioid withdrawal and reduce the risk of infectious comorbidities of illicit opioid use." | 4.90 | Buprenorphine and methadone for opioid addiction during pregnancy. ( Mozurkewich, EL; Rayburn, WF, 2014) |
| "While buprenorphine produces a less severe neonatal abstinence syndrome than methadone, both methadone and buprenorphine are important parts of a complete comprehensive treatment approach for opioid-dependent pregnant women." | 4.88 | Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review. ( Arria, AM; Baewert, A; Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; Selby, P; Stine, SM, 2012) |
| "To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS)." | 4.86 | Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis. ( Clarke, M; Cleary, BJ; Donnelly, J; Fahey, T; Gallagher, PJ; Murphy, DJ; Strawbridge, J, 2010) |
| "This manuscript provides an overview of the current scientific literature on the impact of maternal drug use, specifically opioids and cocaine, during pregnancy on the acute and long-term outcomes of infants and toddlers from birth through age 3 years." | 4.86 | Prenatal drug exposure: infant and toddler outcomes. ( Accornero, VH; Bandstra, ES; Mansoor, E; Morrow, CE, 2010) |
| "Methadone is used as a substitute for illicit opioids during pregnancy." | 4.31 | Long-Term Visual and Neurodevelopmental Outcomes in Two Children with Congenital Nystagmus Secondary to Methadone Exposure In utero. ( Accorsi, P; Fazzi, E; Franzoni, A; Galli, J; Loi, E; Micheletti, S; Pansera, L, 2023) |
| "The potential long-term developmental effects of prenatal methadone and buprenorphine exposure during pregnancy are still largely unknown." | 4.12 | Verbal and nonverbal memory in school-aged children born to opioid-dependent mothers. ( Konijnenberg, C; Melinder, A, 2022) |
| "Methadone is a vital treatment for women with opioid use disorder in pregnancy." | 3.96 | Methadone, Pierre Robin sequence and other congenital anomalies: case-control study. ( Addor, MC; Barisic, I; Cleary, B; de Walle, HEK; Dolk, H; Gatt, M; Klungsoyr, K; Loane, M; Matias Dias, C; McDonnell, B; Neville, A; Pierini, A; Rissmann, A; Tucker, DF; Zurriaga, O, 2020) |
| " We present a case report of a neonate born to a 25-year-old mother enrolled in a medication-assisted treatment program for substance use disorder who was noncompliant in prenatal care, using multiple substances throughout the pregnancy, including gabapentin and fentanyl." | 3.91 | Novel Withdrawal Symptoms of a Neonate Prenatally Exposed to a Fentanyl Analog. ( Davies, TH; Hansen, Z; Loudin, S; Murray, S; Nellhaus, EM, 2019) |
| "There is lack of knowledge about the safety of treatment with methadone and buprenorphine as part of opioid maintenance treatment (OMT) during pregnancy." | 3.91 | Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway. ( Engeland, A; Gabrhelík, R; Handal, M; Lund, IO; Mravčík, V; Nechanská, B; Skurtveit, S, 2019) |
| " When medically indicated, limiting use of multiple psychiatric medications, particularly benzodiazepines and gabapentin, during pregnancy should be considered to improve NAS outcomes." | 3.88 | Impact of psychiatric medication co-exposure on Neonatal Abstinence Syndrome severity. ( Nikita, FNU; Saia, K; Schiff, DM; Shaw, D; Shrestha, H; Thomas, Z; Thomas-Lewis, JA; Wachman, EM; Warden, AH, 2018) |
| "Methadone is used for medication-assisted treatment of heroin addiction during pregnancy." | 3.88 | Prenatal methadone exposure is associated with altered neonatal brain development. ( Anblagan, D; Bastin, ME; Boardman, JP; Cabez, MB; Cooper, ES; Mactier, H; Monnelly, VJ; Quigley, A; Semple, SI, 2018) |
| "To report the presentation and characteristics of strabismus in children with prenatal methadone exposure." | 3.85 | Sensorimotor outcomes in children with prenatal exposure to methadone. ( Jansson, LM; Park, HJ; Yoo, SH, 2017) |
| "The use of implant naltrexone during pregnancy was not associated with higher rates of negative birth outcomes compared with methadone- and buprenorphine-exposed neonates." | 3.85 | A Retrospective Cohort Study of Birth Outcomes in Neonates Exposed to Naltrexone in Utero: A Comparison with Methadone-, Buprenorphine- and Non-opioid-Exposed Neonates. ( Hulse, G; Kelty, E, 2017) |
| "Pregnant women filling at least one prescription for an opioid analgesic at any time during pregnancy for whom opioid exposure characteristics including duration of therapy: short term (<30 days) or long term (≥ 30 days); timing of use: early use (only in the first two trimesters) or late use (extending into the third trimester); and cumulative dose (in morphine equivalent milligrams) were assessed." | 3.81 | Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study. ( Bateman, BT; Desai, RJ; Hernandez-Diaz, S; Huybrechts, KF; Kaltenbach, K; Kerzner, LS; Mogun, H; Patorno, E, 2015) |
| "This article aims to describe neonatal outcomes, clinical correlates, and the rate for neonatal abstinence syndrome (NAS) for women on methadone maintenance therapy." | 3.81 | Maternal methadone treatment and neonatal abstinence syndrome. ( Faisal, M; Li, S; Liu, WF; Singh, K, 2015) |
| "To evaluate the effectiveness of methadone for the treatment of neonatal abstinence syndrome when used according to a preexisting clinical pathway." | 3.80 | Effectiveness of a clinical pathway with methadone treatment protocol for treatment of neonatal abstinence syndrome following in utero drug exposure to substances of abuse*. ( Bhatt-Mehta, V; Ng, CM; Schumacher, RE, 2014) |
| "To describe the prevalence of in utero alcohol and illicit drug exposure in infants born to mothers prescribed methadone in pregnancy, and to compare the accuracy of maternal interview with infant toxicology." | 3.79 | In utero drug and alcohol exposure in infants born to mothers prescribed maintenance methadone. ( Cooper, G; Hassan, H; Mactier, H; McGlone, L, 2013) |
| "This report, the first description of Italian cases of nystagmus related to use of methadone during pregnancy, underlies the importance of a careful investigation of drug use in pregnancy in cases of unexplained congenital nystagmus." | 3.79 | Congenital nystagmus in two infants born from mothers exposed to methadone during pregnancy. ( Battini, R; Cioni, G; Gamucci, A; Tinelli, F, 2013) |
| "In Norway, most opioid-dependent women are in opioid maintenance treatment (OMT) with either methadone or buprenorphine throughout pregnancy." | 3.79 | Neonatal outcomes following in utero exposure to methadone or buprenorphine: a National Cohort Study of opioid-agonist treatment of Pregnant Women in Norway from 1996 to 2009. ( Bakstad, B; Bjarkø, L; Jones, HE; Ravndal, E; Skurtveit, S; Waal, H; Welle-Strand, GK, 2013) |
| " Flash VEPs were recorded within 3 days of birth from 100 healthy infants of drug-misusing mothers prescribed substitute methadone during pregnancy and 50 comparison infants matched for birth weight, gestation, and socioeconomic deprivation." | 3.79 | Neonatal visual evoked potentials in infants born to mothers prescribed methadone. ( Boulton, R; Bradnam, MS; Hamilton, R; Mactier, H; McCulloch, DL; McGlone, L; Weaver, LT, 2013) |
| "Twenty-eight term infants that were exposed to methadone in utero and exhibited symptoms of neonatal abstinence syndrome (NAS) prior to hospital discharge were included into the study." | 3.77 | The impact of infant feeding method on neonatal abstinence scores of methadone-exposed infants. ( Gerlach, K; McQueen, KA; Montelpare, W; Murphy-Oikonen, J, 2011) |
| "To examine the relationship between maternal opioid agonists, methadone, or buprenorphine (BPH), and concurrent psychiatric medication use on length of hospitalization (LOS) among infants with neonatal abstinence syndrome (NAS)." | 3.77 | The relationship between maternal opioid agonists and psychiatric medications on length of hospitalization for neonatal abstinence syndrome. ( Bauchner, H; Bonzagni, A; Byun, J; Newby, PK; Philipp, BL; Vreeland, J; Wachman, EM, 2011) |
| "Methadone is standard pharmacotherapy for opioid-dependent pregnant women, yet the relationship between maternal methadone dose and neonatal abstinence syndrome (NAS) severity is still unclear." | 3.76 | Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome. ( Choo, RE; Concheiro, M; Elko, A; Gray, TR; Huestis, MA; Jansson, LM; Jones, HE; Williams, E, 2010) |
| "Infants born to drug-misusing mothers prescribed methadone in pregnancy are at risk of a range of visual problems, the underlying causes of which are not clear." | 3.76 | Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy. ( Bradnam, MS; Hamilton, R; MacKinnon, JR; Mactier, H; McGlone, L; Russell, HC, 2010) |
| " This study compared the acoustic cry characteristics of infants born to mothers maintained on methadone during pregnancy with those of infants not exposed to methadone during pregnancy." | 3.75 | Acoustic cry characteristics of infants exposed to methadone during pregnancy. ( Quick, ZL; Robb, MP; Woodward, LJ, 2009) |
| " This study investigated whether maternal methadone/buprenorphine dose and nicotine use in pregnancy affects the occurrence and duration of neonatal abstinence syndrome (NAS) in the infant." | 3.75 | Opioid maintenance treatment during pregnancy: occurrence and severity of neonatal abstinence syndrome. A national prospective study. ( Bakstad, B; Ravndal, E; Sarfi, M; Welle-Strand, GK, 2009) |
| "Four hundred and fifty singleton pregnancies of drug-misusing women prescribed substitute methadone in pregnancy." | 3.75 | Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources. ( Dryden, C; Hepburn, M; Mactier, H; Young, D, 2009) |
| "Majority of neonates born to mothers on methadone exhibit neonatal abstinence syndrome and require pharmacological treatment." | 3.74 | Neonatal abstinence syndrome. ( Kurian, O; Serane, VT, 2008) |
| "Descriptive analysis of data in live births of women enrolled in a methadone maintenance programme in 1991-1994 (n = 78) and 1997-2001 (n = 98), including time spent in hospital, treatment for neonatal abstinence syndrome (NAS), admission to the neonatal medical unit (NMU) and follow-up for child health checks." | 3.74 | Methadone-exposed newborn infants: outcome after alterations to a service for mothers and infants. ( D'Souza, SW; Macrory, F; Miles, J; Sims, DG; Sugumar, K, 2007) |
| "We selected 32 women in the city of Vancouver known to have used heroin or methadone during pregnancy between October 2001 and December 2002." | 3.74 | Rooming-in compared with standard care for newborns of mothers using methadone or heroin. ( Abrahams, RR; Janssen, PA; Kelly, SA; Mackintosh, J; Payne, S; Thiessen, PN, 2007) |
| "The volume of feeds, changes in infant body weight, as well as occurrence of adverse clinical effects in infants withdrawing from methadone were studied during the first month of life." | 3.70 | Hyperphagia in neonates withdrawing from methadone. ( Kastner, B; Martinez, A; Taeusch, HW, 1999) |
| " The majority of women in the CDU clinic were treated for narcotic addiction with methadone (90%) but most continued to use heroin during pregnancy (68%)." | 3.70 | The drug epidemic: effects on newborn infants and health resource consumption at a tertiary perinatal centre. ( Davis, PG; Henschke, PN; Kelly, JJ, 2000) |
| "A prospective longitudinal study on the development of children of drug-dependent mothers who used combinations of cocaine, heroin and methadone during pregnancy was carried out in Amsterdam." | 3.69 | Cognitive development at preschool-age of infants of drug-dependent mothers. ( de Graaff, BM; van Baar, A, 1994) |
| " Persistent weight retardation at 12 months was correlated with methadone dosage during pregnancy, but not the need for phenobarbitone therapy." | 3.69 | Infants born to narcotic dependent mothers: physical growth patterns in the first 12 months of life. ( Chant, DC; Gray, PH; Hayes, AJ; Tudehope, DI; Vance, JC, 1997) |
| " To conduct an exploratory study of opiate effects in humans, we compared the sex-dimorphic behavior of male and female offspring of women maintained on methadone during pregnancy to that of demographically matched control subjects." | 3.68 | Effects of prenatal methadone exposure on sex-dimorphic behavior in early school-age children. ( Johnson, HL; Meyer-Bahlburg, HF; Rosen, TS; Sandberg, DE, 1990) |
| "Rat pups were exposed in utero to the opiates methadone or buprenorphine by administering subcutaneous injections to the mothers daily for the duration of pregnancy." | 3.67 | Effects of exposure in utero to methadone and buprenorphine on enkephalin levels in the developing rat brain. ( Olley, JE; Tiong, GK, 1988) |
| "Opioid use disorder is a significant global issue and the rate of opioid use in women of childbearing age and pregnant women is on the rise." | 2.82 | Ophthalmic outcomes in children exposed to opioid maintenance treatment in utero: A systematic review and meta-analysis. ( Baldacchino, A; Conti, AA; Hemmati, Z, 2022) |
| "RR of SIDS between drug-exposed and control infants." | 2.82 | SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants. ( Makarious, L; Oei, JL; Teng, A, 2022) |
| "Methadone maintenance treatment has definite advantages for the mother and is currently recommended in the UK." | 2.47 | The management of heroin misuse in pregnancy: time for a rethink? ( Mactier, H, 2011) |
| "Although substance use has been a worldwide problem at all levels of society since ancient times, recent attention has been focused on the use of legal and illegal substances by the pregnant woman." | 2.38 | The consequences of prenatal substance use for the developing fetus, newborn, and young child. ( Behnke, M; Eyler, FD, 1993) |
| "Methadone is an opioid drug commonly prescribed for treating opioid use disorder in pregnant women and was found to accumulate at high levels in the fetal brain of mice, which fell quickly after birth." | 1.62 | Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry. ( Allen, MR; Atwood, BK; Baucum, AJ; Engleman, EA; Gao, Y; Grecco, GG; Haggerty, DL; Hoffman, H; Huang, JY; Katner, SN; Kim, J; Lu, HC; Masters, AR; Metzger, CE; Mork, BE; Morris, CW; Newell, EA; Reeves, KC; Sheets, PL; Wu, YC; Yamamoto, BK, 2021) |
| "Methadone maintenance treatment (MMT) is the most common treatment for opioid-dependent pregnant women worldwide." | 1.62 | Prenatal methadone exposure impairs adolescent cognition and GABAergic neurodevelopment in a novel rat model of maternal methadone treatment. ( Bird, KM; Lum, JS; Millard, SJ; Newell, KA; Pallimulla, S; Wilkie, J; Wright, IM, 2021) |
| "Poly-drug exposed infants and those treated for neonatal abstinence syndrome performed significantly poorer (p=0." | 1.42 | Infants of opioid-dependent mothers: neurodevelopment at six months. ( Mactier, H; McGlone, L, 2015) |
| "The prevalence of opioid abuse is increasing in North America." | 1.38 | Are infants exposed to methadone in utero at an increased risk for mortality? ( Bridgman-Acker, K; Kelly, LE; Koren, G; Lauwers, A; Madadi, P; Rieder, MJ, 2012) |
| "Buprenorphine as maintenance treatment of opioid dependence during pregnancy has promise and may offer some benefits, but more research is needed, especially regarding induction of actively addicted women during pregnancy." | 1.38 | Treatment of opioid dependence in the setting of pregnancy. ( Martin, PR; Young, JL, 2012) |
| "Methadone treatment is a well-recognised cause of QT interval lengthening in adults." | 1.37 | Maternal methadone therapy increases QTc interval in newborn infants. ( Bhoyar, A; Ewer, AK; Holder, G; Hussain, T; Parikh, R, 2011) |
| " Maternal opiate dosing has been investigated with conflicting results." | 1.36 | Perinatal risk factors for the neonatal abstinence syndrome in infants born to women on methadone maintenance therapy. ( Cook, CM; Jones, MP; Liu, AJ; Murray, H; Nanan, R, 2010) |
| "They were also offered residential treatment before pregnancy and after the child was born." | 1.35 | Patterns in sleep-wakefulness in three-month old infants exposed to methadone or buprenorphine. ( Bakstad, B; Martinsen, H; Røislien, J; Sarfi, M; Waal, H, 2009) |
| "During pregnancy, drug addiction represents one of the most dangerous situations." | 1.35 | Drug addiction during pregnancy: correlations between the placental health and the newborn's outcome - elaboration of a predictive score. ( Boldrini, A; Cuttano, A; Domenici, C; Ghirri, P; Nardini, V; Varese, L, 2009) |
| "Methadone treatment is a well recognised cause of QT interval lengthening in adults." | 1.34 | Maternal methadone may cause arrhythmias in neonates. ( Ewer, AK; Hussain, T, 2007) |
| " This retrospective chart review provides an exploratory examination of newborns treated with either methadone or paregoric for opioid withdrawal and outlines dosage ranges and intervals, side effects, and clinical outcomes of the two regimens." | 1.33 | A chart review comparing paregoric to methadone in the treatment of neonatal opioid withdrawal. ( Wunsch, MJ, 2006) |
| "Higher rates of SIDS were found in infants exposed to opiates alone than in cocaine-exposed infants, but increasing rates of SIDS in cocaine-exposed infants toward the end of the decade suggested that "crack" cocaine may be linked to these increasing rates." | 1.29 | Relationship of maternal substance abuse to subsequent sudden infant death syndrome in offspring. ( Davidson, G; Gaines, J; Habel, L; Jessop, D; Kandall, SR, 1993) |
| "Methadone was found not to be teratogenic to the CD-1 mice." | 1.27 | Developmental toxic effect after subcutaneous injections of methadone in Charles River CD-1 mice. ( Bui, QQ; Sperling, F; West, WL, 1983) |
| "Morphine offspring were significantly different from the controls only in the 120-day-old female group." | 1.27 | Analgesic effect of opiates in offspring of opiate-treated female rats. ( Hovious, JR; Peters, MA, 1984) |
| "Methadone was only one among several risk factors affecting interaction." | 1.27 | Dyads at risk: methadone-maintained women and their four-month-old infants. ( Bernstein, VJ; Jeremy, RJ, 1984) |
| "There are multiple causes for intrauterine growth retardation but one etiology proposed is maternal drugs." | 1.27 | Maternal drug therapy: effect on fetal and neonatal growth and neurobehavior. ( Hill, RM; Tennyson, LM, 1986) |
| "in methadone offspring was not different from controls." | 1.27 | Opiate self-administration in adult offspring of methadone-treated female rats. ( Hovious, JR; Peters, MA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (19.49) | 18.7374 |
| 1990's | 25 (12.82) | 18.2507 |
| 2000's | 23 (11.79) | 29.6817 |
| 2010's | 85 (43.59) | 24.3611 |
| 2020's | 24 (12.31) | 2.80 |
| Authors | Studies |
|---|---|
| Grecco, GG | 3 |
| Haggerty, DL | 2 |
| Reeves, KC | 2 |
| Gao, Y | 4 |
| Maulucci, D | 1 |
| Atwood, BK | 3 |
| Hemmati, Z | 1 |
| Conti, AA | 1 |
| Baldacchino, A | 1 |
| Makarious, L | 1 |
| Teng, A | 1 |
| Oei, JL | 1 |
| Konijnenberg, C | 9 |
| Melinder, A | 9 |
| Gamble, ME | 1 |
| Marfatia, R | 1 |
| Diaz, MR | 1 |
| Lee, JJ | 2 |
| Saraiya, N | 1 |
| Kuzniewicz, MW | 1 |
| Heller, NA | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407] | 55 participants (Actual) | Interventional | 2017-04-20 | Completed | |||
| Fetal Neurobehavior in Non-methadone Maintained Women in Substance Abuse Treatment[NCT00522626] | 19 participants (Actual) | Observational | 2006-08-31 | Completed | |||
| Methadone, Buprenorphine and Fetal Neurobehavior[NCT00653692] | 29 participants (Actual) | Observational | 2007-05-31 | Completed | |||
| Maternal Opioid Treatment: Human Experimental Research[NCT00271219] | Phase 3 | 175 participants (Actual) | Interventional | 2005-07-31 | Completed | ||
| MOms in REcovery (MORE): Defining Optimal Care for Pregnant Women and Infants[NCT04251208] | 444 participants (Actual) | Observational | 2019-07-30 | Active, not recruiting | |||
| Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome[NCT02851303] | Phase 4 | 61 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Fetal heart rate in beats per minute (NCT00522626)
Timeframe: 60 minutes
| Intervention | beats per minute (Mean) |
|---|---|
| Trough Fetal Heart Rate | 142.34 |
(NCT00271219)
Timeframe: birth
| Intervention | cm (Mean) |
|---|---|
| A Methadone | 33.0 |
| B Buprenorphine | 33.8 |
(NCT00271219)
Timeframe: delivery until hospital discharge (min=2 days, max=79 days)
| Intervention | days (Mean) |
|---|---|
| A Methadone | 17.5 |
| B Buprenorphine | 10.0 |
NAS was measured with the MOTHER NAS scale, which includes 28 items, 19 of which are used for scoring and medication decisions. Scores can range from 0 to 42, with higher scores indicating more severe withdrawal. (NCT00271219)
Timeframe: minimum twice daily from birth until NAS no longer measured (min=10 days)
| Intervention | Score on the scale (Mean) |
|---|---|
| A Methadone | 12.8 |
| B Buprenorphine | 11.0 |
(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | percentage of HIV risk behaviors (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
Pregnant women maintained on an opioid agonist medication may require upward adjustment to their medication during the course of pregnant. The Dose Adequacy Measure represented a recordation of dosing adjustments during the course of the study. (NCT00271219)
Timeframe: from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | dose increase per trimester (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
The Addiction Severity Index is a structured clinical interview that assesses problem severity in 7 areas of functioning: alcohol use, drug use, medical, legal, employment, psychosocial, and psychiatric status. Each area of functioning yields a composite scale score between 0 and 1, with higher scores indicating greater problem severity in that area. Only the psychosocial index was examined in this study. (NCT00271219)
Timeframe: at delivery
| Intervention | Score on the scale (Mean) |
|---|---|
| Methadone | .014 |
| Buprenorphine | .088 |
(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | percentage of drug use (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
Neonatal abstinence syndrome (NAS) characterized by hyperirritability of the central nervous system and dysfunction in the autonomic nervous system, gastrointestinal tract, and respiratory system.11 When left untreated, NAS can result in serious illness (e.g., diarrhea, feeding difficulties, weight loss, and seizures) and death. (NCT00271219)
Timeframe: From birth until hospital discharge (min=4 days, max=10, depending on site)
| Intervention | participants (Number) |
|---|---|
| A Methadone | 41 |
| B Buprenorphine | 27 |
Total amount in mg (NCT00271219)
Timeframe: Start of NAS treatment until discontinuation of NAS treatment (min=0 days, max=76 days)
| Intervention | mg (Mean) |
|---|---|
| A Methadone | 10.4 |
| B Buprenorphine | 1.1 |
Assessed through chart review of discharge summary documentation of method of infant feeding at time of discharge (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 5 |
| Methadone | 5 |
Number of days in hospital after birth (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | days (Mean) |
|---|---|
| Morphine | 17.9 |
| Methadone | 16.1 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | days (Mean) |
|---|---|
| Morphine | 14.7 |
| Methadone | 12.8 |
clonidine (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 1 |
| Methadone | 0 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 11 |
| Methadone | 6 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 0 |
| Methadone | 3 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | morphine equivalents mg (Mean) |
|---|---|
| Morphine | 9.86 |
| Methadone | 33.0 |
29 reviews available for methadone and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Ophthalmic outcomes in children exposed to opioid maintenance treatment in utero: A systematic review and meta-analysis.
Topics: Analgesics, Opioid; Buprenorphine; Child; Female; Humans; Infant; Methadone; Opiate Substitution Tre | 2022 |
SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants.
Topics: Analgesics, Opioid; Cocaine; Female; Humans; Infant; Methadone; Observational Studies as Topic; Preg | 2022 |
Prenatal Opioid Exposure and Neurodevelopmental Outcomes.
Topics: Analgesics, Opioid; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal A | 2023 |
Monitoring Prenatal Exposure to Buprenorphine and Methadone.
Topics: Analgesics, Opioid; Buprenorphine; Drug Monitoring; Female; Hair; Humans; Meconium; Methadone; Opiat | 2020 |
Neonatal Abstinence Syndrome: Review of Epidemiology, Care Models, and Current Understanding of Outcomes.
Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Hypnotics and Sedatives; Infant, | 2019 |
Prenatal exposure to methadone or buprenorphine and long-term outcomes: A meta-analysis.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Child; Female; Humans; Infant, Newborn; Male; Methadone; | 2020 |
Cognitive Outcomes of Young Children After Prenatal Exposure to Medications for Opioid Use Disorder: A Systematic Review and Meta-analysis.
Topics: Analgesics, Opioid; Buprenorphine; Child Development; Child, Preschool; Cognition; Cognitive Dysfunc | 2020 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis.
Topics: Child; Child Development; Child, Preschool; Female; Humans; Infant; Methadone; Narcotics; Opioid-Rel | 2019 |
Buprenorphine and methadone for opioid addiction during pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Drug Administration Schedule; Female; Humans; Methadone; Neonatal | 2014 |
Review of the assessment and management of neonatal abstinence syndrome.
Topics: Breast Feeding; Buprenorphine; Clonidine; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neo | 2014 |
Long-Term Outcomes of Infants with Neonatal Abstinence Syndrome.
Topics: Analgesics, Opioid; Child Abuse; Epigenesis, Genetic; Female; Humans; Infant, Newborn; Methadone; Ne | 2016 |
Prenatal drug exposure: infant and toddler outcomes.
Topics: Buprenorphine; Child Development; Child, Preschool; Cocaine; Cocaine-Related Disorders; Female; Hero | 2010 |
The management of heroin misuse in pregnancy: time for a rethink?
Topics: Buprenorphine; Child, Preschool; Developmental Disabilities; Female; Heroin Dependence; Humans; Infa | 2011 |
Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis.
Topics: Cohort Studies; Databases, Bibliographic; Dose-Response Relationship, Drug; Female; Humans; Infant, | 2010 |
Prenatal exposure to methadone and buprenorphine: a review of the potential effects on cognitive development.
Topics: Analgesics, Opioid; Buprenorphine; Child; Child Development; Cognition; Female; Humans; Male; Methad | 2011 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Neonatal abstinence syndrome: therapeutic interventions.
Topics: Female; Humans; Infant; Infant Welfare; Infant, Newborn; Male; Methadone; Morphine; Narcotics; Neona | 2013 |
Neonatal abstinence syndrome: treatment and pediatric outcomes.
Topics: Developmental Disabilities; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinen | 2013 |
Effects of perinatal exposure to methadone on development of neurotransmission: biochemical bases for behavioral alterations.
Topics: Animals; Behavior, Animal; Brain; Female; Methadone; Nervous System; Neurotransmitter Agents; Norepi | 1983 |
Behavioral effects of prenatal exposure to opiates.
Topics: Age Factors; Animals; Animals, Suckling; Behavior, Animal; Female; Heroin; Humans; Methadone; Mice; | 1983 |
The consequences of prenatal substance use for the developing fetus, newborn, and young child.
Topics: Cannabis; Child; Child, Preschool; Congenital Abnormalities; Developmental Disabilities; Female; Hea | 1993 |
Effects of in-utero opiate exposure: new paradigms for old questions.
Topics: Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related | 1994 |
A new look at some old mechanisms in human newborns: taste and tactile determinants of state, affect, and action.
Topics: Affect; Crying; Female; Heart Rate; Humans; Infant Care; Infant, Newborn; Male; Methadone; Mother-Ch | 1994 |
Bridging species: a new look and new questions.
Topics: Female; Humans; Infant Care; Infant, Newborn; Male; Methadone; Mother-Child Relations; Mothers; Preg | 1994 |
Methadone during pregnancy: the search for a valid animal model.
Topics: Animals; Behavior, Animal; Child; Child, Preschool; Disease Models, Animal; Female; Heroin Dependenc | 1993 |
Early development of infants exposed to drugs prenatally.
Topics: Alcoholism; Child Abuse; Child Development; Child, Preschool; Cocaine; Cocaine-Related Disorders; Et | 1999 |
Perinatal exposure to methadone: how do early biochemical alterations cause neurofunctional disturbances?
Topics: Adrenergic Fibers; Animals; Brain; Catecholamines; Female; Methadone; Pregnancy; Prenatal Exposure D | 1988 |
Developmental effects of narcotics.
Topics: Analysis of Variance; Animals; Body Weight; Female; Fetal Diseases; Growth; Humans; Methadone; Nalox | 1986 |
10 trials available for methadone and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Randomized Clinical Trial of Standard- Versus High-Calorie Formula for Methadone-Exposed Infants: A Feasibility Study.
Topics: Double-Blind Method; Energy Intake; Feasibility Studies; Female; Humans; Infant Formula; Infant, New | 2018 |
Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes.
Topics: Adult; Buprenorphine; Child Development; Child, Preschool; Cognition; Female; Humans; Infant, Newbor | 2018 |
The effect of prenatal alcohol co-exposure on neonatal abstinence syndrome in infants born to mothers in opioid maintenance treatment.
Topics: Adult; Alcohol Drinking; Female; Humans; Incidence; Infant, Newborn; Length of Stay; Methadone; Neon | 2016 |
Are male neonates more vulnerable to neonatal abstinence syndrome than female neonates?
Topics: Birth Weight; Buprenorphine; Double-Blind Method; Female; Humans; Infant, Newborn; Male; Methadone; | 2011 |
Predicting treatment for neonatal abstinence syndrome in infants born to women maintained on opioid agonist medication.
Topics: Adolescent; Adult; Analgesics, Opioid; Birth Weight; Buprenorphine; Dose-Response Relationship, Drug | 2012 |
Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Buprenorphine; Double-Blind Method; Female; Humans; | 2012 |
Neonatal neurobehavior effects following buprenorphine versus methadone exposure.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Infant Behavior; Infant, Newbo | 2012 |
Therapy of the neonatal abstinence syndrome with tincture of opium or morphine drops.
Topics: Double-Blind Method; Female; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence | 2005 |
Maternal vagal tone change in response to methadone is associated with neonatal abstinence syndrome severity in exposed neonates.
Topics: Adult; Apgar Score; Arrhythmia, Sinus; Electrocardiography; Female; Heart; Humans; Infant, Newborn; | 2007 |
157 other studies available for methadone and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Prenatal opioid exposure reprograms the behavioural response to future alcohol reward.
Topics: Analgesics, Opioid; Animals; Ethanol; Female; Male; Methadone; Mice; Pregnancy; Prenatal Exposure De | 2022 |
Verbal and nonverbal memory in school-aged children born to opioid-dependent mothers.
Topics: Analgesics, Opioid; Buprenorphine; Child; Female; Humans; Longitudinal Studies; Methadone; Opiate Su | 2022 |
Prenatal methadone exposure leads to long-term memory impairments and disruptions of dentate granule cell function in a sex-dependent manner.
Topics: Analgesics, Opioid; Animals; Dentate Gyrus; Female; Humans; Male; Memory, Long-Term; Methadone; Preg | 2022 |
Effect of Neonatal Abstinence Syndrome Treatment Status and Maternal Depressive Symptomatology on Maternal Reports of Infant Behaviors.
Topics: Analgesics, Opioid; Female; Humans; Infant; Infant, Newborn; Methadone; Mothers; Neonatal Abstinence | 2023 |
Long-Term Visual and Neurodevelopmental Outcomes in Two Children with Congenital Nystagmus Secondary to Methadone Exposure In utero.
Topics: Child; Female; Humans; Infant; Methadone; Nystagmus, Congenital; Pregnancy; Prenatal Exposure Delaye | 2023 |
Health and Neurodevelopment of Children Born to Opioid-Dependent Mothers at School Entry.
Topics: Child of Impaired Parents; Child, Preschool; Female; Health Status; Humans; Infant; Infant, Newborn; | 2020 |
Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway.
Topics: Adult; Buprenorphine; Child Development; Czech Republic; Female; Humans; Infant, Newborn; Logistic M | 2019 |
Salivary cortisol levels relate to cognitive performance in children prenatally exposed to methadone or buprenorphine.
Topics: Analgesics, Opioid; Buprenorphine; Child; Child Development; Cohort Studies; Female; Humans; Hydroco | 2020 |
Educational achievement at age 9.5 years of children born to mothers maintained on methadone during pregnancy.
Topics: Achievement; Child; Educational Status; Female; Humans; Logistic Models; Male; Mathematics; Methadon | 2019 |
Long-time effects of prenatal morphine, tramadol, methadone, and buprenorphine exposure on seizure and anxiety in immature rats.
Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Buprenorphine; Female; Locomotion; Male; Maze | 2020 |
Diverse changes in myelin protein expression in rat brain after perinatal methadone exposure.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Animals; Brain; Female; Male; Methadone; Myelin Basic | 2019 |
Prenatal exposure to methadone or buprenorphine impairs cognitive performance in young adult rats.
Topics: Animals; Animals, Newborn; Buprenorphine; Cognition; Female; Infusion Pumps, Implantable; Male; Memo | 2020 |
Orchestrated Testing of Formula Type to Reduce Length of Stay in Neonatal Abstinence Syndrome.
Topics: Energy Intake; Female; Humans; Infant Formula; Infant, Newborn; Lactose; Length of Stay; Methadone; | 2020 |
Neurobehavior of newborn infants exposed prenatally to methadone and identification of a neurobehavioral profile linked to poorer neurodevelopmental outcomes at age 24 months.
Topics: Adult; Analgesics, Opioid; Attention; Case-Control Studies; Child Development; Female; Humans; Infan | 2020 |
Prenatal methadone exposure and child developmental outcomes in 2-year-old children.
Topics: Adult; Child Development; Child, Preschool; Confounding Factors, Epidemiologic; Female; Humans; Infa | 2021 |
Prenatal methadone exposure impairs adolescent cognition and GABAergic neurodevelopment in a novel rat model of maternal methadone treatment.
Topics: Analgesics, Opioid; Animals; Brain; Brain-Derived Neurotrophic Factor; Cognition; Disease Models, An | 2021 |
Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Brain; Female; Humans; Male; Maternal Exposure; Metha | 2021 |
Affective decision-making in children prenatally exposed to opioids.
Topics: Analgesics, Opioid; Buprenorphine; Child; Child Development; Cognition; Decision Making; Female; Hum | 2021 |
Prenatal opioid administration induces shared alterations to the maternal and offspring gut microbiome: A preliminary analysis.
Topics: Analgesics, Opioid; Animals; Female; Gastrointestinal Microbiome; Male; Methadone; Mice; Pregnancy; | 2021 |
Variations in Infant CYP2B6 Genotype Associated with the Need for Pharmacological Treatment for Neonatal Abstinence Syndrome in Infants of Methadone-Maintained Opioid-Dependent Mothers.
Topics: Adult; Analgesics, Opioid; Cohort Studies; Cytochrome P-450 CYP2B6; Female; Genetic Variation; Human | 2017 |
A Retrospective Cohort Study of Birth Outcomes in Neonates Exposed to Naltrexone in Utero: A Comparison with Methadone-, Buprenorphine- and Non-opioid-Exposed Neonates.
Topics: Adult; Australia; Buprenorphine; Drug Administration Routes; Female; Humans; Incidence; Infant, Newb | 2017 |
An Initiative to Improve the Quality of Care of Infants With Neonatal Abstinence Syndrome.
Topics: Female; Hospital Costs; Humans; Infant, Newborn; Length of Stay; Male; Methadone; Morphine; Narcotic | 2017 |
Sensorimotor outcomes in children with prenatal exposure to methadone.
Topics: Age of Onset; Exotropia; Female; Humans; Infant; Methadone; Narcotics; Neonatal Abstinence Syndrome; | 2017 |
Increased DNA Methylation of ABCB1, CYP2D6, and OPRM1 Genes in Newborn Infants of Methadone-Maintained Opioid-Dependent Mothers.
Topics: Adult; Analgesics, Opioid; ATP Binding Cassette Transporter, Subfamily B; Case-Control Studies; Coho | 2017 |
A retrospective cohort study of the health of children prenatally exposed to methadone, buprenorphine or naltrexone compared with non-exposed control children.
Topics: Adult; Buprenorphine; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Longitudinal | 2017 |
Neonatal Outcomes in a Medicaid Population With Opioid Dependence.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Narcotics; Opioid-Related Disorders; Preg | 2018 |
Early inhibitory control and working memory abilities of children prenatally exposed to methadone.
Topics: Adult; Behavioral Symptoms; Case-Control Studies; Child, Preschool; Executive Function; Female; Huma | 2018 |
Prenatal methadone exposure is associated with altered neonatal brain development.
Topics: Brain; Child; Child Development; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; Fem | 2018 |
Quality improvement initiative to improve inpatient outcomes for Neonatal Abstinence Syndrome.
Topics: Adult; Female; Hospital Costs; Humans; Infant, Newborn; Inpatients; Length of Stay; Male; Methadone; | 2018 |
ERP correlates of cognitive control in children prenatally exposed to methadone or buprenorphine.
Topics: Buprenorphine; Child; Cognition; Evoked Potentials; Female; Humans; Longitudinal Studies; Male; Meth | 2018 |
Impact of psychiatric medication co-exposure on Neonatal Abstinence Syndrome severity.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Buprenorphine; Female; Gabapentin; Humans; Infant; Infan | 2018 |
Novel Withdrawal Symptoms of a Neonate Prenatally Exposed to a Fentanyl Analog.
Topics: Anticonvulsants; Clonidine; Female; Fentanyl; Humans; Infant, Newborn; Levetiracetam; Methadone; Myo | 2019 |
Could prenatal food insecurity influence neonatal abstinence syndrome severity?
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Food Supply; Humans; Methadone; Neonatal Abstinenc | 2019 |
Children exposed to maternal methadone treatment prenatally are at risk of abnormal neurodevelopment.
Topics: Child; Female; Humans; Methadone; Pregnancy; Prenatal Exposure Delayed Effects | 2019 |
Hospitalization of children after prenatal exposure to opioid maintenance therapy during pregnancy: a national registry study from the Czech Republic.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Case-Control Studies; Child, Preschool; Czech Republic; Di | 2019 |
Implications of perinatal buprenorphine exposure on infant head circumference at birth.
Topics: Buprenorphine; Female; Humans; Infant; Infant, Newborn; Male; Methadone; Neonatal Abstinence Syndrom | 2021 |
Methadone, Pierre Robin sequence and other congenital anomalies: case-control study.
Topics: Adult; Case-Control Studies; Cleft Palate; Comorbidity; Europe; Female; Gestational Age; Humans; Inf | 2020 |
High Accumulation of Methadone Compared with Buprenorphine in Fetal Rat Brain after Maternal Exposure.
Topics: Analgesics, Opioid; Animals; Body Weight; Brain; Buprenorphine; Female; Fetus; Male; Maternal-Fetal | 2019 |
Prevalence of Maternal-Risk Factors Related to Neonatal Abstinence Syndrome in a Commercial Claims Database: 2011-2015.
Topics: Adult; Analgesics, Opioid; Drug Prescriptions; Female; Humans; Incidence; Infant, Newborn; Insurance | 2019 |
Neonatal visual evoked potentials in infants born to mothers prescribed methadone.
Topics: Cohort Studies; Evoked Potentials, Visual; Female; Humans; Infant, Newborn; Male; Methadone; Pilot P | 2013 |
Development of sensitization to methamphetamine in offspring prenatally exposed to morphine, methadone and buprenorphine.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Buprenorphine; Central Nervous System Stimulants; Fem | 2014 |
Deviant smooth pursuit in preschool children exposed prenatally to methadone or buprenorphine and tobacco affects integrative visuomotor capabilities.
Topics: Analysis of Variance; Buprenorphine; Child, Preschool; Cohort Studies; Female; Humans; Male; Methado | 2013 |
Congenital nystagmus in two infants born from mothers exposed to methadone during pregnancy.
Topics: Female; Humans; Infant; Infant, Newborn; Maternal Exposure; Methadone; Narcotics; Nystagmus, Congeni | 2013 |
In utero drug and alcohol exposure in infants born to mothers prescribed maintenance methadone.
Topics: Analgesics, Opioid; Central Nervous System Depressants; Ethanol; Female; Humans; Illicit Drugs; Infa | 2013 |
Maternal stress and behavioral adaptation in methadone- or buprenorphine-exposed toddlers.
Topics: Adult; Anxiety; Buprenorphine; Child; Child, Preschool; Depression; Family; Female; Humans; Longitud | 2013 |
Development of auditory event-related potentials in infants prenatally exposed to methadone.
Topics: Acoustic Stimulation; Adult; Auditory Cortex; Electroencephalography; Evoked Potentials, Auditory; F | 2014 |
Effectiveness of a clinical pathway with methadone treatment protocol for treatment of neonatal abstinence syndrome following in utero drug exposure to substances of abuse*.
Topics: Analgesics, Opioid; Clinical Protocols; Female; Humans; Infant, Newborn; Intensive Care Units, Neona | 2014 |
Effect of prenatal methadone on reinstated behavioral sensitization induced by methamphetamine in adolescent rats.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Female; Methadone; Methamphetamine; Mo | 2014 |
Visual outcome in infants born to drug-misusing mothers prescribed methadone in pregnancy.
Topics: Evoked Potentials, Visual; Eye Diseases; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; | 2014 |
Searching the right way to treat neonatal abstinence syndrome*.
Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregna | 2014 |
Neonatal abstinence syndrome: on the evidence to add breastfeeding to any clinical pathway.
Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregna | 2014 |
The authors reply.
Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregna | 2014 |
The opioid system and brain development: effects of methadone on the oligodendrocyte lineage and the early stages of myelination.
Topics: Animals; Axons; Brain; Cell Lineage; Cell Proliferation; Female; Methadone; Myelin Basic Protein; My | 2014 |
Identification of early developmental deficits in infants with prenatal heroin, methadone, and other opioid exposure.
Topics: Analgesics, Opioid; Child Development; Developmental Disabilities; Female; Heroin; Humans; Infant; I | 2015 |
Executive function in preschool children prenatally exposed to methadone or buprenorphine.
Topics: Analgesics, Opioid; Buprenorphine; Case-Control Studies; Child; Child Development; Child, Preschool; | 2015 |
Visual selective attention is impaired in children prenatally exposed to opioid agonist medication.
Topics: Analgesics, Opioid; Attention; Buprenorphine; Case-Control Studies; Child, Preschool; Female; Humans | 2015 |
Infants of opioid-dependent mothers: neurodevelopment at six months.
Topics: Adult; Analgesics, Opioid; Case-Control Studies; Child Development; Female; Humans; Infant; Infant, | 2015 |
Management of neonatal abstinence syndrome in the newborn nursery.
Topics: Female; Humans; Infant, Newborn; Methadone; Mother-Child Relations; Neonatal Abstinence Syndrome; Pr | 2014 |
Maternal Substance Use and Neonatal Abstinence Syndrome: A Descriptive Study.
Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Length of Stay; Methadone; Mothers; Neonatal Abs | 2015 |
Growth and developmental outcome of infants with in-utero exposure to methadone vs buprenorphine.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Infant, Premature | 2015 |
Beneficial effects of co-treatment with dextromethorphan on prenatally methadone-exposed offspring.
Topics: Animals; Antitussive Agents; Dextromethorphan; Female; Male; Methadone; Morphine Dependence; Narcoti | 2015 |
Maternal methadone treatment and neonatal abstinence syndrome.
Topics: Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Length of Stay; Logistic Models | 2015 |
Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study.
Topics: Adolescent; Adult; Analgesics, Opioid; Cohort Studies; Dose-Response Relationship, Drug; Female; Hum | 2015 |
ADHD risk alleles associated with opiate addiction: study of addicted parents and their children.
Topics: Adolescent; Alleles; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Female; | 2016 |
Mother-child interaction and cognitive development in children prenatally exposed to methadone or buprenorphine.
Topics: Adult; Buprenorphine; Case-Control Studies; Child Development; Cognition; Female; Humans; Infant, Ne | 2016 |
Neonatal abstinence syndrome and the gastrointestinal tract.
Topics: Analgesics, Opioid; Buprenorphine; Child; Child, Preschool; Dysbiosis; Female; Gastrointestinal Trac | 2016 |
An Atypical Withdrawal Syndrome in Neonates Prenatally Exposed to Gabapentin and Opioids.
Topics: Amines; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid | 2017 |
Early Treatment for Neonatal Abstinence Syndrome: A Palliative Approach.
Topics: Analgesics, Opioid; Female; Humans; Infant, Newborn; Length of Stay; Male; Methadone; Neonatal Absti | 2017 |
Neonatal abstinence syndrome.
Topics: Female; Humans; Infant; Infant, Newborn; Male; Maternal-Fetal Exchange; Methadone; Morphine; Mothers | 2008 |
Outcome in infants exposed to methadone in utero.
Topics: Developmental Disabilities; Female; Humans; Infant; Infant, Newborn; Methadone; Narcotics; Pregnancy | 2008 |
Acoustic cry characteristics of infants exposed to methadone during pregnancy.
Topics: Abnormalities, Drug-Induced; Acoustics; Analgesics, Opioid; Crying; Female; Humans; Infant Welfare; | 2009 |
[Substitution treatment of drug addicts during pregnancy: consequences for the children?].
Topics: Buprenorphine; Developmental Disabilities; Female; Humans; Infant, Newborn; Methadone; Narcotics; Ne | 2009 |
Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources.
Topics: Adolescent; Adult; Breast Feeding; Dose-Response Relationship, Drug; Drug Users; Female; Gestational | 2009 |
Opioid maintenance treatment during pregnancy: occurrence and severity of neonatal abstinence syndrome. A national prospective study.
Topics: Adult; Buprenorphine; Cohort Studies; Female; Humans; Infant, Newborn; Male; Methadone; Neonatal Abs | 2009 |
Prenatal methadone exposure and neonatal neurobehavioral functioning.
Topics: Analysis of Variance; Female; Humans; Infant, Newborn; Lethargy; Maternal Exposure; Methadone; Movem | 2009 |
Drug addiction during pregnancy: correlations between the placental health and the newborn's outcome - elaboration of a predictive score.
Topics: Adult; Analgesics, Opioid; Cannabis; Cocaine; Ethanol; Female; Gestational Age; Humans; Infant, Newb | 2009 |
Patterns in sleep-wakefulness in three-month old infants exposed to methadone or buprenorphine.
Topics: Adult; Buprenorphine; Chronobiology Disorders; Female; Humans; Infant; Infant Behavior; Infant, Newb | 2009 |
Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy.
Topics: Child; Child, Preschool; Evoked Potentials, Visual; Eye Diseases; Female; Humans; Infant; Maternal-F | 2010 |
Infant neurobehavior following prenatal exposure to methadone or buprenorphine: results from the neonatal intensive care unit network neurobehavioral scale.
Topics: Adult; Akathisia, Drug-Induced; Buprenorphine; Female; Humans; Infant, Newborn; Intensive Care Units | 2010 |
Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine.
Topics: Analgesics; Animals; Buprenorphine; Disease Models, Animal; Drug Tolerance; Female; Heroin Dependenc | 2010 |
Perinatal risk factors for the neonatal abstinence syndrome in infants born to women on methadone maintenance therapy.
Topics: Adult; Female; Humans; Infant, Newborn; Logistic Models; Methadone; Narcotics; Neonatal Abstinence S | 2010 |
Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome.
Topics: Adult; Analgesics, Opioid; Cocaine; Cocaine-Related Disorders; Female; Gestational Age; Humans; Infa | 2010 |
Maternal methadone therapy increases QTc interval in newborn infants.
Topics: Case-Control Studies; Electrocardiography; Female; Humans; Infant, Newborn; Long QT Syndrome; Male; | 2011 |
The relationship between maternal opioid agonists and psychiatric medications on length of hospitalization for neonatal abstinence syndrome.
Topics: Boston; Buprenorphine; Cross-Sectional Studies; Drug Interactions; Drug Therapy, Combination; Female | 2011 |
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine | 2012 |
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine | 2012 |
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine | 2012 |
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine | 2012 |
The impact of infant feeding method on neonatal abstinence scores of methadone-exposed infants.
Topics: Adolescent; Adult; Analysis of Variance; Breast Feeding; Female; Humans; Infant Formula; Infant, New | 2011 |
Methadone and metabolites in hair of methadone-assisted pregnant women and their infants.
Topics: Adolescent; Adult; Female; Hair; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; O | 2012 |
Are infants exposed to methadone in utero at an increased risk for mortality?
Topics: Adult; Analgesics, Opioid; Cause of Death; Female; Humans; Infant; Infant Mortality; Infant, Newborn | 2012 |
Treatment of opioid dependence in the setting of pregnancy.
Topics: Adolescent; Alcohol-Related Disorders; Analgesics, Opioid; Buprenorphine; Child; Comorbidity; Delive | 2012 |
Neural tract development of infants born to methadone-maintained mothers.
Topics: Analgesics, Opioid; Brain; Brain Mapping; Developmental Disabilities; Diffusion Tensor Imaging; Fema | 2012 |
Neurodevelopmental investigation of the mirror neurone system in children of women receiving opioid maintenance therapy during pregnancy.
Topics: Adult; Analysis of Variance; Buprenorphine; Case-Control Studies; Child, Preschool; Developmental Di | 2013 |
Neonatal outcomes following in utero exposure to methadone or buprenorphine: a National Cohort Study of opioid-agonist treatment of Pregnant Women in Norway from 1996 to 2009.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cohort Studies; Female; Follow-Up Studies; Humans; Infant, | 2013 |
Strabismus in infants of opiate-dependent mothers.
Topics: Australia; Codeine; Cross-Sectional Studies; Female; Heroin; Humans; Infant; Infant, Newborn; Male; | 2003 |
Prenatal methadone exposure: effects on behavior in early infancy.
Topics: Adult; Analysis of Variance; Child Development; Female; Follow-Up Studies; Humans; Infant; Infant Be | 1982 |
Differential effects of gestational buprenorphine, naloxone, and methadone on mesolimbic mu opioid and ORL1 receptor G protein coupling.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Autoradiography; Buprenorphine; Dose-Response Relatio | 2004 |
Neonatal abstinence syndrome in methadone-exposed infants is altered by level of prenatal tobacco exposure.
Topics: Adult; Analysis of Variance; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrom | 2004 |
Secondary amenorrhea: an unusual twist.
Topics: Adolescent; Amenorrhea; Clitoris; Female; Humans; Methadone; Narcotics; Pregnancy; Prenatal Exposure | 2005 |
A chart review comparing paregoric to methadone in the treatment of neonatal opioid withdrawal.
Topics: Analgesics, Opioid; Documentation; Drug Administration Schedule; Female; Humans; Infant, Newborn; Ma | 2006 |
Methadone-exposed newborn infants: outcome after alterations to a service for mothers and infants.
Topics: Delivery of Health Care; Female; Humans; Infant Care; Infant, Newborn; Interprofessional Relations; | 2007 |
Maternal methadone may cause arrhythmias in neonates.
Topics: Electrocardiography; Female; Humans; Infant, Newborn; Long QT Syndrome; Methadone; Narcotics; Pregna | 2007 |
Rooming-in compared with standard care for newborns of mothers using methadone or heroin.
Topics: Adult; Breast Feeding; British Columbia; Child Custody; Cohort Studies; Comorbidity; Female; Heroin; | 2007 |
Visual evoked potentials in infants exposed to methadone in utero.
Topics: Case-Control Studies; Child Development; Evoked Potentials, Visual; Female; Humans; Infant, Newborn; | 2008 |
Delays in growth and biochemical development of rat brain caused by maternal methadone administration: are the alterations in synaptogenesis and cellular maturation independent of reduced maternal food intake?
Topics: Aging; Animals; Body Weight; Brain; Eating; Female; Methadone; Organ Size; Ornithine Decarboxylase; | 1982 |
Analgesic effect of opiates in offspring of opiate-treated female rats.
Topics: Analgesics, Opioid; Animals; Female; Male; Methadone; Morphine; Pregnancy; Prenatal Exposure Delayed | 1984 |
Children of methadone-maintained mothers: follow-up to 18 months of age.
Topics: Abnormalities, Drug-Induced; Developmental Disabilities; Female; Follow-Up Studies; Humans; Infant; | 1982 |
In utero exposure to methadone produces a stable decrease of the cortex 5-HT transport system in rats.
Topics: Animals; Biological Transport; Cerebral Cortex; Female; Imipramine; Methadone; Naloxone; Pregnancy; | 1983 |
Somatic and neurobiological alterations in the progeny of female rats treated with methadone prior to mating.
Topics: Animals; Body Weight; Brain; Cerebellum; Female; Male; Methadone; Organ Size; Pregnancy; Prenatal Ex | 1983 |
Motoric and attentional behavior in infants of methadone-maintained women.
Topics: Aging; Attention; Behavior; Female; Humans; Infant; Male; Methadone; Motor Activity; Opioid-Related | 1983 |
Dyads at risk: methadone-maintained women and their four-month-old infants.
Topics: Adolescent; Adult; Female; Humans; Infant; Longitudinal Studies; Maternal Behavior; Methadone; Mothe | 1984 |
Chronic maternal methadone exposure and response to analgesics.
Topics: Analgesics; Animals; Brain Chemistry; Female; Male; Methadone; Pregnancy; Prenatal Exposure Delayed | 1984 |
Neonatal opiate withdrawal alters the reactivity of adult rats to the hot-plate.
Topics: Animals; Dose-Response Relationship, Drug; Escape Reaction; Female; Humans; Male; Methadone; Methady | 1984 |
A comprehensive care program for pregnant addicts: obstetrical, neonatal, and child development outcomes.
Topics: Adult; Birth Weight; Child Development; Counseling; Delivery, Obstetric; Female; Gestational Age; He | 1984 |
Altered respiratory control in newborn puppies after chronic prenatal exposure to alpha-1-acetylmethadol (LAAM).
Topics: Animals; Animals, Newborn; Carbon Dioxide; Chloral Hydrate; Dogs; Female; Humans; Methadone; Methady | 1982 |
Fetal and postnatal growth of children born to narcotic-dependent women.
Topics: Body Height; Female; Fetus; Growth; Heroin Dependence; Humans; Infant, Newborn; Longitudinal Studies | 1983 |
Developmental toxic effect after subcutaneous injections of methadone in Charles River CD-1 mice.
Topics: Animals; Body Weight; Feeding Behavior; Female; Fetus; Growth; Injections, Subcutaneous; Male; Metha | 1983 |
Methadone outcome studies: is it more than the methadone?
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Met | 1982 |
Some effects of maternal drug addiction on the neonate.
Topics: Arousal; Child Behavior; Female; Habituation, Psychophysiologic; Heroin; Humans; Infant, Newborn; Ma | 1982 |
Norepinephrine content of the rat kidney during development: alterations induced by perinatal methadone.
Topics: Animals; Animals, Newborn; Body Weight; Female; Kidney; Methadone; Norepinephrine; Organ Size; Pregn | 1982 |
Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.
Topics: Aging; Animals; Animals, Newborn; Female; Heart; Methadone; Myocardium; Ornithine Decarboxylase; Pol | 1982 |
Enhanced sensitivity to methadone in adult rats perinatally exposed to methadone.
Topics: Animals; Body Temperature Regulation; Body Weight; Female; Lactation; Methadone; Nociceptors; Pregna | 1981 |
Alterations in the development of catecholamine turnover induced by perinatal methadone: differences in central vs. peripheral sympathetic nervous systems.
Topics: Animals; Brain; Catecholamines; Central Nervous System; Female; Kinetics; Methadone; Myocardium; Per | 1981 |
Cognitive development at preschool-age of infants of drug-dependent mothers.
Topics: Child, Preschool; Cocaine; Cognition; Female; Heroin; Humans; Infant; Infant, Newborn; Language; Mal | 1994 |
[Neonatal abstinence syndrome and maternal toxicological profile].
Topics: Dose-Response Relationship, Drug; Female; Gestational Age; Heroin; Humans; Infant, Newborn; Maternal | 1994 |
Children of substance abusers: the life experiences of children of opiate addicts in methadone maintenance.
Topics: Adolescent; Adult; Antisocial Personality Disorder; Bipolar Disorder; Child; Child Abuse; Child Abus | 1994 |
A comparison of meconium, maternal urine and neonatal urine for detection of maternal drug use during pregnancy.
Topics: Adult; Cocaine; Dronabinol; Female; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Imm | 1994 |
Prenatal exposure to methadone delays the development of striatal cholinergic neurons.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cell Size; Cellular Senescence; Choline O-Acetyltransf | 1993 |
Relationship of maternal substance abuse to subsequent sudden infant death syndrome in offspring.
Topics: Adult; Age Factors; Chi-Square Distribution; Cocaine; Confidence Intervals; Female; Heroin; Humans; | 1993 |
Perinatal methadone exposure produces physical dependence and altered behavioral development in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Weight; Drinking; Eating; Female; Male; Methad | 1996 |
Perinatal exposure to methadone affects central cholinergic activity in the weanling rat.
Topics: Acetylcholine; Animals; Animals, Newborn; Brain; Brain Mapping; Female; Humans; Infant, Newborn; Mal | 1996 |
Effects of prenatal exposure to opioids on focused attention in toddlers during free play.
Topics: Attention; Child, Preschool; Female; Heroin; Heroin Dependence; Humans; Male; Methadone; Mother-Chil | 1996 |
Postnatal methadone exposure doe not prevent prenatal methadone-induced changes in striatal cholinergic neurons.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Animals; Dopamine; Female; Hydroxyindoleacetic Acid; | 1996 |
Microencephaly and selective decreases in cerebellar Purkinje cell numbers following combined exposure to ethanol and methadone during rat brain development.
Topics: Animals; Body Weight; Cell Count; Cell Division; Central Nervous System Depressants; Cerebellum; Dru | 1997 |
Infants born to narcotic dependent mothers: physical growth patterns in the first 12 months of life.
Topics: Adult; Cohort Studies; Female; Fetal Growth Retardation; Growth; Humans; Infant; Infant, Newborn; Me | 1997 |
In contrast to cocaine, prenatal exposure to methadone does not produce detectable alterations in the developing mouse brain.
Topics: Aging; Animals; Animals, Newborn; Astrocytes; Brain; Cerebral Cortex; Cocaine; Cocaine-Related Disor | 1998 |
Attachment behavior and its antecedents in offspring born to methadone-maintained women.
Topics: Adult; Black or African American; Case-Control Studies; Chi-Square Distribution; Child of Impaired P | 1999 |
Hyperphagia in neonates withdrawing from methadone.
Topics: Adult; Birth Weight; Body Weight; Female; Humans; Hyperphagia; Incidence; Infant, Newborn; Linear Mo | 1999 |
The drug epidemic: effects on newborn infants and health resource consumption at a tertiary perinatal centre.
Topics: Adult; Ambulatory Care Facilities; Amphetamines; Australia; Benzodiazepines; Cannabis; Cocaine; Como | 2000 |
Perinatal opioids reduce striatal nerve growth factor content in rat striatum.
Topics: Animals; Animals, Newborn; Buprenorphine; Corpus Striatum; Female; Male; Methadone; Narcotics; Nerve | 2001 |
Coordinated outpatient care of the narcotic-dependent infant.
Topics: Ambulatory Care; Child Health Services; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; | 2001 |
Prenatal exposure to methadone affects central cholinergic neuronal activity in the weanling rat.
Topics: Acetylcholine; Animals; Brain; Dopamine; Female; Methadone; Neurons; Norepinephrine; Parasympathetic | 1991 |
The effect of prenatal methadone exposure of development and nociception during the early postnatal period of the rat.
Topics: Animals; Female; Methadone; Morphine; Nociceptors; Pregnancy; Prenatal Exposure Delayed Effects; Rat | 1990 |
The effect of prenatal exposure to methadone on neurotransmitters in neonatal rats.
Topics: Acetylcholine; Animals; Animals, Newborn; Brain Chemistry; Corpus Striatum; Dopamine; Female; Male; | 1990 |
Effects of prenatal methadone exposure on sex-dimorphic behavior in early school-age children.
Topics: Child; Female; Gender Identity; Humans; Male; Methadone; Pregnancy; Prenatal Exposure Delayed Effect | 1990 |
Neonatal behavior after drug dependent pregnancy.
Topics: Child; Child Behavior; Child, Preschool; Developmental Disabilities; Electroencephalography; Female; | 1989 |
Clinical studies of infants and children exposed prenatally to heroin.
Topics: Child Behavior; Child Development; Child, Preschool; Cognition; Female; Heroin Dependence; Humans; I | 1989 |
Developmental consequences of prenatal exposure to methadone.
Topics: Child Development; Child, Preschool; Female; Growth; Humans; Infant; Infant, Newborn; Intelligence; | 1989 |
Behaviour in first year after drug dependent pregnancy.
Topics: Child Behavior; Child Development; Electroencephalography; Female; Humans; Illicit Drugs; Infant; In | 1989 |
The use of tricyclic antidepressants in methadone maintained pregnant women and infant outcome.
Topics: Adult; Antidepressive Agents, Tricyclic; Apgar Score; Birth Weight; Demography; Female; Heroin Depen | 1988 |
Methadone maintenance has a tragic price.
Topics: Adolescent; Child; Child Behavior Disorders; Female; Humans; Infant, Newborn; Methadone; Neonatal Ab | 1988 |
Effects of exposure in utero to methadone and buprenorphine on enkephalin levels in the developing rat brain.
Topics: Animals; Brain; Buprenorphine; Dose-Response Relationship, Drug; Enkephalins; Female; Methadone; Pre | 1988 |
[Effects of maternal methadone addiction on the growth and health of the fetus].
Topics: Embryonic and Fetal Development; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone | 1988 |
Maternal drug therapy: effect on fetal and neonatal growth and neurobehavior.
Topics: Aminopterin; Amphetamines; Animals; Anticoagulants; Anticonvulsants; Antihypertensive Agents; Birth | 1986 |
Effect of maternal methadone administration on the development of multiple forms of monoamine oxidase in rat brain and liver.
Topics: Animals; Brain; Female; Isoenzymes; Liver; Methadone; Monoamine Oxidase; Opioid-Related Disorders; P | 1986 |
Mother-infant interaction in multiproblem families: finding those at risk.
Topics: Adult; Child Development; Female; Humans; Infant; Methadone; Mother-Child Relations; Opioid-Related | 1986 |
Factors affecting head growth and intellectual function in children of drug addicts.
Topics: Age Factors; Cephalometry; Child Development; Cognition; Female; Follow-Up Studies; Head; Heroin Dep | 1985 |
Opiate self-administration in adult offspring of methadone-treated female rats.
Topics: Animals; Body Weight; Drinking; Female; Methadone; Morphine; Narcotics; Pregnancy; Prenatal Exposure | 1985 |
Offspring born to methadone-maintained women.
Topics: Female; Humans; Infant; Infant, Newborn; Longitudinal Studies; Maternal-Fetal Exchange; Methadone; P | 1985 |