methadone has been researched along with Death, Sudden, Cardiac in 19 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain." | 8.86 | Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010) |
| "Nearly 20 studies showed a prolonged QT interval secondary to methadone in patients exhibiting the following features: (1) patients with cardiac pathologies, notably bradycardia, congenital long QT interval, myocardial pathologies related to AIDS and electrolyte disturbances; (2) patients receiving concomitant treatment with substances known to prolong QT interval, such as psychoactive stimulants, narcoleptics, tricyclic antidepressants, antiarrhythmic agents, macrolids, quinolones, non diuretic hypokalemiants and certain corticoids; (3) patients receiving treatments that inhibit methadone's metabolism, particularly those that act on the cytochrome P450 3A4 such as SSRI, antifungal agents, some macrolids and some retroviral agents." | 4.88 | [Review of cases of prolonged QTC and wave burst arrhythmia in patients treated with methadone]. ( Berleur, MP; Kerbage, H; Laqueille, X; Richa, S; Scart-Gres, C, 2012) |
| "Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain." | 4.86 | Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010) |
| "Sudden cardiac death was recorded in five patients, and torsade de pointes was recorded in seven other patients." | 1.39 | Drug-induced long QT in adult psychiatric inpatients: the 5-year cross-sectional ECG Screening Outcome in Psychiatry study. ( Berney, P; Dayer, P; Gaspoz, JM; Gex-Fabry, M; Girardin, FR; Shah, D, 2013) |
| "In this study, a case of sudden cardiac arrest in a patient on chronic methadone therapy is presented." | 1.39 | Sudden cardiac arrest in a patient on chronic methadone after the addition of azithromycin. ( Twilla, JD; Winton, JC, 2013) |
| "A total of 22 sudden cardiac death cases with therapeutic levels of methadone (mean 0." | 1.35 | A community-based evaluation of sudden death associated with therapeutic levels of methadone. ( Chugh, SS; Gunson, K; Jui, J; Reinier, K; Socoteanu, C; Waltz, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (52.63) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Upadhya, B | 1 |
| Ntim, W | 1 |
| Brandon Stacey, R | 1 |
| Henderson, R | 1 |
| Leedy, D | 1 |
| O'Brien, FX | 1 |
| Knovich, MA | 1 |
| Girardin, FR | 1 |
| Gex-Fabry, M | 1 |
| Berney, P | 1 |
| Shah, D | 1 |
| Gaspoz, JM | 1 |
| Dayer, P | 1 |
| Lusetti, M | 1 |
| Licata, M | 1 |
| Silingardi, E | 1 |
| Reggiani Bonetti, L | 1 |
| Palmiere, C | 1 |
| Acciavatti, T | 1 |
| Martinotti, G | 1 |
| Corbo, M | 1 |
| Cinosi, E | 1 |
| Lupi, M | 1 |
| Ricci, F | 1 |
| Di Scala, R | 1 |
| D'Ugo, E | 1 |
| De Francesco, V | 1 |
| De Caterina, R | 1 |
| di Giannantonio, M | 1 |
| Kim, HK | 1 |
| Manini, A | 1 |
| Behr, ER | 1 |
| Camm, AJ | 1 |
| Modesto-Lowe, V | 1 |
| Brooks, D | 1 |
| Petry, N | 1 |
| Perrin-Terrin, A | 1 |
| Pathak, A | 1 |
| Lapeyre-Mestre, M | 1 |
| Karch, SB | 1 |
| Laqueille, X | 1 |
| Richa, S | 1 |
| Kerbage, H | 1 |
| Scart-Gres, C | 1 |
| Berleur, MP | 1 |
| Winton, JC | 1 |
| Twilla, JD | 1 |
| Stimmel, B | 2 |
| Harris, JD | 1 |
| de Leon-Casasola, OA | 1 |
| Andersen, HT | 1 |
| Ekgren, JS | 1 |
| Byrne, A | 1 |
| Waal, H | 1 |
| Krook, AL | 1 |
| Hansteen, V | 1 |
| Ehret, GB | 1 |
| Desmeules, JA | 1 |
| Broers, B | 1 |
| Chugh, SS | 1 |
| Socoteanu, C | 1 |
| Reinier, K | 1 |
| Waltz, J | 1 |
| Jui, J | 1 |
| Gunson, K | 1 |
| Junttila, MJ | 1 |
| Gonzalez, M | 1 |
| Lizotte, E | 1 |
| Benito, B | 1 |
| Vernooy, K | 1 |
| Sarkozy, A | 1 |
| Huikuri, HV | 1 |
| Brugada, P | 1 |
| Brugada, J | 1 |
| Brugada, R | 1 |
4 reviews available for methadone and Death, Sudden, Cardiac
| Article | Year |
|---|---|
Methadone deaths: risk factors in pain and addicted populations.
Topics: Analgesics, Opioid; Chronic Disease; Death, Sudden, Cardiac; Drug Overdose; Humans; Methadone; Opiat | 2010 |
[Review of cases of prolonged QTC and wave burst arrhythmia in patients treated with methadone].
Topics: Adult; Analgesics, Opioid; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug Interactio | 2012 |
Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology.
Topics: Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Electr | 2007 |
Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias.
Topics: Adult; Age of Onset; Anesthetics; Antidepressive Agents, Tricyclic; Brugada Syndrome; Cocaine; Death | 2008 |
1 trial available for methadone and Death, Sudden, Cardiac
| Article | Year |
|---|---|
QT interval prolongation: prevalence, risk factors and pharmacovigilance data among methadone-treated patients in France.
Topics: Adult; Death, Sudden; Death, Sudden, Cardiac; Female; France; Heart Diseases; Humans; Long QT Syndro | 2011 |
14 other studies available for methadone and Death, Sudden, Cardiac
| Article | Year |
|---|---|
Prolongation of QTc intervals and risk of death among patients with sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Death, Sudden, Cardiac; Echocardiography; Electrocardiography; Female; F | 2013 |
Drug-induced long QT in adult psychiatric inpatients: the 5-year cross-sectional ECG Screening Outcome in Psychiatry study.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Case-Control Studies; Citalopram; Cross-Sectional Stu | 2013 |
Therapeutic and recreational methadone cardiotoxicity.
Topics: Adult; Cardiotoxicity; Death, Sudden, Cardiac; Forensic Toxicology; Humans; Male; Methadone; Myocard | 2016 |
Psychotropic drugs and ventricular repolarisation: The effects on QT interval, T-peak to T-end interval and QT dispersion.
Topics: Cross-Sectional Studies; Death, Sudden, Cardiac; Electrocardiography; Female; Heart Ventricles; Huma | 2017 |
Methadone-associated sudden cardiac death?
Topics: Adult; Analgesics, Opioid; Autopsy; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug O | 2008 |
Letter by Behr and Camm regarding article, "Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias".
Topics: Adult; Age of Onset; Anesthetics; Antidepressive Agents, Tricyclic; Brugada Syndrome; Cocaine; Death | 2008 |
Is it time to reformulate racemic methadone?
Topics: Adult; Arrhythmias, Cardiac; Chemistry, Pharmaceutical; Chronic Disease; Death, Sudden, Cardiac; Fem | 2011 |
Sudden cardiac arrest in a patient on chronic methadone after the addition of azithromycin.
Topics: Azithromycin; Death, Sudden, Cardiac; Drug Therapy, Combination; Heart Arrest; Humans; Male; Methado | 2013 |
Methadone and affairs of the heart and of the brain.
Topics: Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Electrocardiography; Humans; Long QT Syndr | 2003 |
Oral erythromycin and the risk of sudden death.
Topics: Anti-Bacterial Agents; Cytochrome P-450 Enzyme Inhibitors; Death, Sudden, Cardiac; Drug Interactions | 2005 |
[Heart arrhythmia and sudden death during methadone therapy].
Topics: Death, Sudden; Death, Sudden, Cardiac; Humans; Long QT Syndrome; Methadone; Narcotics; Opioid-Relate | 2007 |
Methadone and QTc prolongation.
Topics: Analgesics, Opioid; Death, Sudden, Cardiac; Drug Interactions; Electrocardiography; Heroin Dependenc | 2007 |
[Methadone treatment and heart arrhythmia].
Topics: Death, Sudden; Death, Sudden, Cardiac; Humans; Long QT Syndrome; Methadone; Narcotics | 2007 |
A community-based evaluation of sudden death associated with therapeutic levels of methadone.
Topics: Adult; Analgesics, Opioid; Autopsy; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug O | 2008 |