methadone has been researched along with Critical Illness in 9 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methadone is a synthetic opioid analgesic with potential advantages over other commonly used opioids." | 2.53 | Methadone analgesia in the critically ill. ( Elefritz, JL; Lyaker, MR; Murphy, CV; Papadimos, TJ, 2016) |
| " Different approaches, such as weight-based and formula-based methods, have been used to determine the initial methadone dosing regimen." | 2.48 | Selection of the initial methadone regimen for the management of iatrogenic opioid abstinence syndrome in critically ill children. ( Boyles, KA; Johnson, PN; Miller, JL, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Fernández-Tobar, R | 1 |
| Chamorro-Jambrina, C | 1 |
| Pérez-Torres, M | 1 |
| Castiñeiras-Amor, B | 1 |
| Alcántara-Carmona, S | 1 |
| Romera-Ortega, MA | 1 |
| Azimi, HA | 1 |
| Keats, KR | 1 |
| Sulejmani, E | 1 |
| Ortiz, K | 1 |
| Waller, J | 1 |
| Wayne, N | 1 |
| Reichheld, AM | 1 |
| Hills-Evans, K | 1 |
| Sheehan, JK | 1 |
| Tocci, NX | 1 |
| Tandon, M | 1 |
| Hsu, D | 1 |
| Marshall, J | 1 |
| O'Donoghue, S | 1 |
| Stevens, JP | 1 |
| Jones, GM | 1 |
| Elefritz, JL | 2 |
| Murphy, CV | 2 |
| Papadimos, TJ | 1 |
| Lyaker, MR | 2 |
| Ruan, X | 1 |
| Kaye, AJ | 1 |
| Kaye, AD | 1 |
| Johnson, PN | 1 |
| Boyles, KA | 1 |
| Miller, JL | 1 |
| Al-Qadheeb, NS | 1 |
| Roberts, RJ | 1 |
| Griffin, R | 1 |
| Garpestad, E | 1 |
| Ruthazer, R | 1 |
| Devlin, JW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit[NCT02025855] | Phase 4 | 46 participants (Anticipated) | Interventional | 2014-01-31 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for methadone and Critical Illness
| Article | Year |
|---|---|
Methadone analgesia in the critically ill.
Topics: Adult; Analgesics, Opioid; Child; Critical Illness; Delirium; Humans; Intensive Care Units; Methadon | 2016 |
Selection of the initial methadone regimen for the management of iatrogenic opioid abstinence syndrome in critically ill children.
Topics: Analgesics, Opioid; Child; Clinical Trials as Topic; Critical Illness; Disease Management; Dose-Resp | 2012 |
7 other studies available for methadone and Critical Illness
| Article | Year |
|---|---|
Methadone as a rescue drug for difficult-to-sedate critically ill patients suffering from ARDS related to SARS-CoV-2 infection.
Topics: COVID-19; Critical Illness; Humans; Methadone; Respiratory Distress Syndrome; SARS-CoV-2 | 2022 |
Use of Methadone Versus Oxycodone to Facilitate Weaning of Parenteral Opioids in Critically Ill Adult Patients.
Topics: Adult; Analgesics, Opioid; COVID-19; Critical Illness; Humans; Methadone; Oxycodone; Prospective Stu | 2023 |
A national survey of approaches to manage the ICU patient with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Critical Care; Critical Illness; Hospitalization; Hospitals; Huma | 2019 |
Methadone in the critically ill-An unlikely player in intensive care medicine.
Topics: Critical Care; Critical Illness; Humans; Intensive Care Units; Medicine; Methadone | 2016 |
Methadone analgesia in the critically ill.
Topics: Analgesia; Analgesics, Opioid; Critical Illness; Humans; Methadone; Pain Management | 2016 |
Methadone analgesia in the critically ill.
Topics: Analgesia; Critical Illness; Humans; Methadone; Pain; Pain Management | 2016 |
Impact of enteral methadone on the ability to wean off continuously infused opioids in critically ill, mechanically ventilated adults: a case-control study.
Topics: Adult; Aged; Analgesics, Opioid; Case-Control Studies; Critical Illness; Enteral Nutrition; Female; | 2012 |