methadone has been researched along with Cough in 20 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether the administration of intravenous (IV) lidocaine before the induction of anaesthesia in premedicated dogs reduces the cough response associated with endotracheal intubation and the propofol dose required." | 9.22 | Effect of intravenous lidocaine on cough response to endotracheal intubation in propofol-anaesthetized dogs. ( Cafrita, IC; Clark, L; Panti, A, 2016) |
| "In this report-the fourth of a series on codeine and its alternates for pain and cough relief-an attempt is made to evaluate, on the basis of experimental and clinical data, and wherever possible in comparison with codeine, the effectiveness of a number of antitussive substances currently in clinical use." | 8.74 | Codeine and its alternates for pain and cough relief . 4. Potential alternates for cough relief. ( Eddy, NB; Friebel, H; Hahn, KJ; Halbach, H, 1969) |
| "Vulnerability to delirium was potentially caused by coadministration of methadone, which can inhibit the CYP2D6 isozyme." | 7.73 | Dextromethorphan-induced delirium and possible methadone interaction. ( Lotrich, FE; Pollock, BG; Rosen, J, 2005) |
| "To determine whether the administration of intravenous (IV) lidocaine before the induction of anaesthesia in premedicated dogs reduces the cough response associated with endotracheal intubation and the propofol dose required." | 5.22 | Effect of intravenous lidocaine on cough response to endotracheal intubation in propofol-anaesthetized dogs. ( Cafrita, IC; Clark, L; Panti, A, 2016) |
| "In this report-the fourth of a series on codeine and its alternates for pain and cough relief-an attempt is made to evaluate, on the basis of experimental and clinical data, and wherever possible in comparison with codeine, the effectiveness of a number of antitussive substances currently in clinical use." | 4.74 | Codeine and its alternates for pain and cough relief . 4. Potential alternates for cough relief. ( Eddy, NB; Friebel, H; Hahn, KJ; Halbach, H, 1969) |
| "Vulnerability to delirium was potentially caused by coadministration of methadone, which can inhibit the CYP2D6 isozyme." | 3.73 | Dextromethorphan-induced delirium and possible methadone interaction. ( Lotrich, FE; Pollock, BG; Rosen, J, 2005) |
| "Methadone has several desirable pharmacological features, including a long elimination half-life." | 2.90 | Intraoperative methadone for postoperative pain after laparoscopic hysterectomy: Protocol for a randomised, double-blind trial. ( Brix, LD; Friesgaard, KD; Kristensen, CB; Nikolajsen, L; Rian, O, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 3 (15.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Friesgaard, KD | 1 |
| Brix, LD | 1 |
| Kristensen, CB | 1 |
| Rian, O | 1 |
| Nikolajsen, L | 1 |
| Murphy, GS | 1 |
| Szokol, JW | 1 |
| Avram, MJ | 1 |
| Greenberg, SB | 1 |
| Marymont, JH | 1 |
| Shear, T | 1 |
| Parikh, KN | 1 |
| Patel, SS | 1 |
| Gupta, DK | 1 |
| Panti, A | 1 |
| Cafrita, IC | 1 |
| Clark, L | 1 |
| WINTER, CA | 1 |
| FLATAKER, L | 1 |
| HEROLD, K | 1 |
| ROSIERE, CE | 1 |
| WINDER, CV | 1 |
| WAX, J | 1 |
| NERRETER, W | 1 |
| RASCH, M | 1 |
| HENGEN, O | 1 |
| KASPAREK, H | 1 |
| PITARMA SABINO, AC | 1 |
| CHAPPEL, CI | 1 |
| VONSEEMANN, C | 1 |
| SCHMIDT, W | 1 |
| BOYD, EM | 1 |
| BUELL, M | 1 |
| Lotrich, FE | 1 |
| Rosen, J | 1 |
| Pollock, BG | 1 |
| Boura, AL | 1 |
| Haddlesey, DI | 1 |
| Harry, EJ | 1 |
| Lewis, JW | 1 |
| Mayor, PA | 1 |
| Eichhorn, A | 1 |
| Eddy, NB | 1 |
| Friebel, H | 1 |
| Hahn, KJ | 1 |
| Halbach, H | 1 |
| Bucher, UM | 1 |
| Kade, F | 1 |
| Bucher, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics of Methadone in Adults Undergoing Cardiac Surgery With Extracorporeal Circulation[NCT05075265] | 30 participants (Anticipated) | Observational | 2021-10-02 | Not yet recruiting | |||
| Intraoperative Methadone for Postoperative Pain in Patients Undergoing Tonsillectomy - a Randomized Controlled Trial[NCT05445856] | Phase 4 | 130 participants (Anticipated) | Interventional | 2022-11-28 | Recruiting | ||
| Clinical Effectiveness and Safety of Intraoperative Methadone in Patients Undergoing Laparoscopic Hysterectomy: a Prospective, Double-blind, Randomised Controlled Trial[NCT03908060] | 126 participants (Actual) | Interventional | 2019-05-06 | Active, not recruiting | |||
| Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients[NCT02989597] | Phase 4 | 10 participants (Actual) | Interventional | 2017-07-29 | Terminated (stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.) | ||
| The Effect of Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery: A Randomized, Double-Blinded Controlled Trial[NCT02747875] | 26 participants (Actual) | Interventional | 2016-09-30 | Terminated (stopped due to Drug Shortage) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The distribution of the total opioid dose in the first 24 hours will be evaluated by randomization group (methadone vs. fentanyl) and differences between groups will be tested. It is hypothesized that compared to fentanyl, methadone administered intraoperative will result in a significantly lower total opioid dose (morphine or oxycodone) during the first 24 hour postoperative period. Assuming no difference between the two treatment strategies in the population, a total sample size of 52 in each group will provide 80% power to detect an effect size of 0.1. Significance will be measured as a 30% reduction in postoperative pain requirement. (NCT02747875)
Timeframe: 24 hours
| Intervention | mg postop morphine equivelant 24hr (Mean) |
|---|---|
| Control - Fentanyl | 0.55 |
| Treatment - Methadone | 0.48 |
Opioid-related adverse events will be monitored closely and a secondary analysis will compare the incidence of side effects between the two groups during the first 24-hour postoperative period. The Pearson's contingency chi-square test will be used to evaluate any differences between the randomization groups in opioid-related adverse events during the first 24-hour postoperative period. (NCT02747875)
Timeframe: 24 hours
| Intervention | events (Mean) | |||
|---|---|---|---|---|
| Ondansetron Doses | Emesis Episodes | Hypoventilation Episodes | Arrhythmias | |
| Control - Fentanyl | 3.81 | 2.72 | 0 | 0 |
| Treatment - Methadone | 3.43 | 2.08 | 0 | 0 |
3 reviews available for methadone and Cough
| Article | Year |
|---|---|
ANTITUSSIVE DRUGS.
Topics: Antipsychotic Agents; Antitussive Agents; Chemistry, Pharmaceutical; Codeine; Cough; Dextromoramide; | 1963 |
[Antitussive agents. 34].
Topics: Acetylcysteine; Acute Disease; Alkaloids; Animals; Antitussive Agents; Bronchitis; Central Nervous S | 1969 |
Codeine and its alternates for pain and cough relief . 4. Potential alternates for cough relief.
Topics: Alkaloids; Animals; Antitussive Agents; Cats; Codeine; Cough; Dogs; Guinea Pigs; Histamine H1 Antago | 1969 |
3 trials available for methadone and Cough
| Article | Year |
|---|---|
Intraoperative methadone for postoperative pain after laparoscopic hysterectomy: Protocol for a randomised, double-blind trial.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Cough; Critical Care; Double-Blind Method; Female; Huma | 2019 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Intraoperative Methadone for the Prevention of Postoperative Pain: A Randomized, Double-blinded Clinical Trial in Cardiac Surgical Patients.
Topics: Aged; Analgesics, Opioid; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Cough; Double-Blind M | 2015 |
Effect of intravenous lidocaine on cough response to endotracheal intubation in propofol-anaesthetized dogs.
Topics: Acepromazine; Analgesics, Opioid; Anesthetics, Intravenous; Anesthetics, Local; Animals; Arterial Pr | 2016 |
14 other studies available for methadone and Cough
| Article | Year |
|---|---|
Antitussive action of d-isomethadone and d-methadone in dogs.
Topics: Animals; Antitussive Agents; Cough; Dogs; Methadone | 1952 |
[Polamidon as cough remedy in treatment of menopausal deficiencies with estrogens].
Topics: Contraceptive Agents, Female; Cough; Estradiol Congeners; Estrogens; Female; Humans; Menopause; Meth | 1953 |
Ammonia cough elicited through a tracheal side tube in unanesthetized dogs: comparative antitussive bioassay of four morphine derivatives and methadone in terms of ammonia thresholds.
Topics: Ammonia; Animals; Antitussive Agents; Biological Assay; Cough; Dogs; Methadone; Morphine Derivatives | 1956 |
[The problem of cough drug addiction].
Topics: Behavior, Addictive; Codeine; Cough; Ephedrine; Ethylmorphine; Humans; Methadone; Substance-Related | 1957 |
[Dextromethadone and its antitussive effect].
Topics: Antitussive Agents; Codeine; Cough; Methadone | 1957 |
[Antitussive effect of a new substance].
Topics: Antitussive Agents; Cough; Methadone | 1958 |
[Clinical tests with a new synthetic anti-tussive: R-522. (Preliminary results)].
Topics: Cough; Methadone | 1960 |
[Clinical experiences with a new antitussive and expectoration-promoting preparation].
Topics: Antitussive Agents; Cough; Methadone; Sputum | 1960 |
Methadone and respiratory tract fluid.
Topics: Body Fluids; Cough; Humans; Inorganic Chemicals; Methadone; Respiratory System; Ventilators, Mechani | 1950 |
CHILD killed by cough linctus.
Topics: Child; Cough; Expectorants; Homicide; Humans; Methadone | 1951 |
Dextromethorphan-induced delirium and possible methadone interaction.
Topics: Aged; Analgesics, Opioid; Antitussive Agents; Cough; Delirium; Depressive Disorder; Dextromethorphan | 2005 |
Structural requirement for antitussive activity in some novel 16-substituted derivatives of 6,14-endoethenotetrahydrothebaine.
Topics: Analgesia; Animals; Antitussive Agents; Cats; Codeine; Cough; Guinea Pigs; Methadone; Morphinans; Mo | 1968 |
Respiratory changes following reflexogenic expiratory twitches.
Topics: Animals; Anthracenes; Benzoates; Codeine; Columbidae; Cough; Decerebrate State; Methadone; Nalorphin | 1973 |
[Characteristic expiratory thrusts in pigeons].
Topics: Amino Alcohols; Animals; Benzoates; Chlorpromazine; Codeine; Columbidae; Cough; Electric Stimulation | 1967 |