Page last updated: 2024-10-30

methadone and Cot Death

methadone has been researched along with Cot Death in 18 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Research Excerpts

ExcerptRelevanceReference
"To identify and describe infant deaths presenting suddenly and unexpectedly in whom there was a history of maternal methadone consumption or misuse of drugs during pregnancy."7.81Maternal use of methadone and risk of sudden neonatal death. ( Cohen, MC; Coombs, RC; Morley, SR, 2015)
" This study aims to determine the infant mortality rate of infants born to women on a methadone program during pregnancy and to identify any modifiable risk factors."7.76Infant mortality among women on a methadone program during pregnancy. ( Burns, L; Conroy, E; Mattick, RP, 2010)
"Moderately strong evidence indicates lower risk of preterm birth, greater birth weight and larger head circumference with buprenorphine treatment of maternal opioid use disorder during pregnancy compared with methadone treatment, and no greater harms."4.93Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child. ( Amick, HR; Jones, HE; Joyce, AR; Kim, MM; Mann, AL; Murrelle, EL; Zedler, BK, 2016)
"Parents of infants with neonatal abstinence syndrome (NAS) in the NICU may have questions about the long-term consequences of prenatal exposure to methadone, both asked and unasked."4.93Long-Term Outcomes of Infants with Neonatal Abstinence Syndrome. ( Armstrong, K; Brooks, SS; Clark, L; Cline, GJ; Germain, AM; Maguire, DJ; Shaffer-Hudkins, E; Taylor, S, 2016)
"To identify and describe infant deaths presenting suddenly and unexpectedly in whom there was a history of maternal methadone consumption or misuse of drugs during pregnancy."3.81Maternal use of methadone and risk of sudden neonatal death. ( Cohen, MC; Coombs, RC; Morley, SR, 2015)
" This study aims to determine the infant mortality rate of infants born to women on a methadone program during pregnancy and to identify any modifiable risk factors."3.76Infant mortality among women on a methadone program during pregnancy. ( Burns, L; Conroy, E; Mattick, RP, 2010)
" Apnea density and episodes of periodic breathing exceeded the 95th percentile for normal infants in 12 (38%) of 32 of cocaine-exposed infants vs only 1 (6%) of 18 opiate-exposed infants."3.67Prenatal cocaine exposure is associated with respiratory pattern abnormalities. ( Chasnoff, IJ; Hunt, CE; Kaplan, D; Kletter, R, 1989)
"In 50 infants born to women who continued to take heroin during all or part of their pregnancy the drug withdrawal symptoms were mild and were noted in 21 infants (42%)."3.67Maternal narcotic abuse and the newborn. ( Alroomi, LG; Davidson, J; Evans, TJ; Galea, P; Howat, R, 1988)
"Drug addiction during pregnancy has been managed in two ways: the detoxification program and the methadone-maintenance treatment program."3.65Drug addiction in pregnancy and the neonate. ( Ackerman, BD; Blinick, G; Jerez, E; Wallach, RC, 1976)
"RR of SIDS between drug-exposed and control infants."2.82SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants. ( Makarious, L; Oei, JL; Teng, A, 2022)
"The new definition of the term sudden infant death syndrome (SIDS) and the criteria introduced in San Diego for the subclassification of cases have been used to re-classify the first 100 consecutive cases of sudden and unexpected infant deaths that were registered with the German SIDS study (GeSID)."1.33The San Diego definition of SIDS: practical application and comparison with the GeSID classification. ( Bajanowski, T; Brinkmann, B; Vennemann, M, 2006)
"The diagnosis of sudden infant death syndrome (SIDS) is one of exclusion."1.31Toxicologic analysis in cases of possible sudden infant death syndrome: a worthwhile exercise? ( Ellis, PS; Hulewicz, B; Langlois, NE; Little, D, 2002)
"Higher rates of SIDS were found in infants exposed to opiates alone than in cocaine-exposed infants, but increasing rates of SIDS in cocaine-exposed infants toward the end of the decade suggested that "crack" cocaine may be linked to these increasing rates."1.29Relationship of maternal substance abuse to subsequent sudden infant death syndrome in offspring. ( Davidson, G; Gaines, J; Habel, L; Jessop, D; Kandall, SR, 1993)
"This incidence of SIDS was 5."1.26Sudden unexpected death in infants of narcotic-dependent mothers. ( Falciglia, H; Kandall, SR; Rajegowda, BK, 1978)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19909 (50.00)18.7374
1990's1 (5.56)18.2507
2000's2 (11.11)29.6817
2010's4 (22.22)24.3611
2020's2 (11.11)2.80

Authors

AuthorsStudies
Chighine, A1
Porcu, M1
Ferino, G1
Lenigno, N1
Trignano, C1
d'Aloja, E1
Locci, E1
Makarious, L1
Teng, A1
Oei, JL1
Cohen, MC1
Morley, SR1
Coombs, RC1
Zedler, BK1
Mann, AL1
Kim, MM1
Amick, HR1
Joyce, AR1
Murrelle, EL1
Jones, HE1
Maguire, DJ1
Taylor, S1
Armstrong, K1
Shaffer-Hudkins, E1
Germain, AM1
Brooks, SS1
Cline, GJ1
Clark, L1
Burns, L1
Conroy, E1
Mattick, RP1
Bajanowski, T1
Brinkmann, B1
Vennemann, M1
Olsen, GD1
Lees, MH1
Shannon, DC1
Kelly, DH1
Naeye, RL1
Kandall, SR2
Gaines, J1
Habel, L1
Davidson, G1
Jessop, D1
Langlois, NE1
Ellis, PS1
Little, D1
Hulewicz, B1
Rajegowda, BK1
Falciglia, H1
Blinick, G1
Wallach, RC1
Jerez, E1
Ackerman, BD1
Rosen, TS1
Johnson, HL1
Chasnoff, IJ1
Hunt, CE1
Kletter, R1
Kaplan, D1
Alroomi, LG1
Davidson, J1
Evans, TJ1
Galea, P1
Howat, R1
Ward, SL1
Schuetz, S1
Kirshna, V1
Bean, X1
Wingert, W1
Wachsman, L1
Keens, TG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407]55 participants (Actual)Interventional2017-04-20Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for methadone and Cot Death

ArticleYear
SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2022, Volume: 107, Issue:6

    Topics: Analgesics, Opioid; Cocaine; Female; Humans; Infant; Methadone; Observational Studies as Topic; Preg

2022
Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child.
    Addiction (Abingdon, England), 2016, Volume: 111, Issue:12

    Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Fetal Death; F

2016
Long-Term Outcomes of Infants with Neonatal Abstinence Syndrome.
    Neonatal network : NN, 2016, Volume: 35, Issue:5

    Topics: Analgesics, Opioid; Child Abuse; Epigenesis, Genetic; Female; Humans; Infant, Newborn; Methadone; Ne

2016
SIDS and near-sids (first of two parts).
    The New England journal of medicine, 1982, Apr-22, Volume: 306, Issue:16

    Topics: ABO Blood-Group System; Adult; Arrhythmias, Cardiac; Autonomic Nervous System; Birth Order; Brain; C

1982

Other Studies

14 other studies available for methadone and Cot Death

ArticleYear
Infant urinary metabolomic profile in a fatal acute methadone intoxication.
    International journal of legal medicine, 2022, Volume: 136, Issue:2

    Topics: Asphyxia; Female; Humans; Infant; Infant, Newborn; Magnetic Resonance Spectroscopy; Metabolomics; Me

2022
Maternal use of methadone and risk of sudden neonatal death.
    Acta paediatrica (Oslo, Norway : 1992), 2015, Volume: 104, Issue:9

    Topics: Adult; Female; Humans; Infant, Newborn; Male; Methadone; Narcotics; Opioid-Related Disorders; Perina

2015
Infant mortality among women on a methadone program during pregnancy.
    Drug and alcohol review, 2010, Volume: 29, Issue:5

    Topics: Adult; Female; Humans; Infant Mortality; Infant, Newborn; Live Birth; Medical Record Linkage; Methad

2010
The San Diego definition of SIDS: practical application and comparison with the GeSID classification.
    International journal of legal medicine, 2006, Volume: 120, Issue:6

    Topics: Age Distribution; Bedding and Linens; California; Child Abuse; Child Development; Forensic Medicine;

2006
Ventilatory response to carbon dioxide of infants following chronic prenatal methadone exposure.
    The Journal of pediatrics, 1980, Volume: 96, Issue:6

    Topics: Carbon Dioxide; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone; Oxygen; Partial

1980
Sudden infant death.
    Scientific American, 1980, Volume: 242, Issue:4

    Topics: Adipose Tissue; Adipose Tissue, Brown; Carotid Body; Erythrocytes, Abnormal; Female; Humans; Hypoxia

1980
Relationship of maternal substance abuse to subsequent sudden infant death syndrome in offspring.
    The Journal of pediatrics, 1993, Volume: 123, Issue:1

    Topics: Adult; Age Factors; Chi-Square Distribution; Cocaine; Confidence Intervals; Female; Heroin; Humans;

1993
Toxicologic analysis in cases of possible sudden infant death syndrome: a worthwhile exercise?
    The American journal of forensic medicine and pathology, 2002, Volume: 23, Issue:2

    Topics: Autopsy; Cause of Death; Diagnostic Tests, Routine; Female; Humans; Infant; Infant, Newborn; Male; M

2002
Sudden unexpected death in infants of narcotic-dependent mothers.
    Early human development, 1978, Volume: 2, Issue:3

    Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Male; Maternal-Fetal

1978
Drug addiction in pregnancy and the neonate.
    American journal of obstetrics and gynecology, 1976, May-15, Volume: 125, Issue:2

    Topics: Alcoholic Intoxication; Birth Weight; Diazepam; Female; Heroin Dependence; Hospitalization; Humans;

1976
Drug-addicted mothers, their infants, and SIDS.
    Annals of the New York Academy of Sciences, 1988, Volume: 533

    Topics: Adult; Alcohol Drinking; Cocaine; Developmental Disabilities; Female; Heroin Dependence; Humans; Inf

1988
Prenatal cocaine exposure is associated with respiratory pattern abnormalities.
    American journal of diseases of children (1960), 1989, Volume: 143, Issue:5

    Topics: Apnea; Cheyne-Stokes Respiration; Cocaine; Female; Humans; Infant, Newborn; Methadone; Pregnancy; Pr

1989
Maternal narcotic abuse and the newborn.
    Archives of disease in childhood, 1988, Volume: 63, Issue:1

    Topics: Adolescent; Adult; Female; Heroin; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinenc

1988
Abnormal sleeping ventilatory pattern in infants of substance-abusing mothers.
    American journal of diseases of children (1960), 1986, Volume: 140, Issue:10

    Topics: Age Factors; Cocaine; Female; Heart Rate; Heroin; Humans; Infant; Male; Methadone; Narcotics; Phency

1986