methadone has been researched along with Cot Death in 18 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To identify and describe infant deaths presenting suddenly and unexpectedly in whom there was a history of maternal methadone consumption or misuse of drugs during pregnancy." | 7.81 | Maternal use of methadone and risk of sudden neonatal death. ( Cohen, MC; Coombs, RC; Morley, SR, 2015) |
| " This study aims to determine the infant mortality rate of infants born to women on a methadone program during pregnancy and to identify any modifiable risk factors." | 7.76 | Infant mortality among women on a methadone program during pregnancy. ( Burns, L; Conroy, E; Mattick, RP, 2010) |
| "Moderately strong evidence indicates lower risk of preterm birth, greater birth weight and larger head circumference with buprenorphine treatment of maternal opioid use disorder during pregnancy compared with methadone treatment, and no greater harms." | 4.93 | Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child. ( Amick, HR; Jones, HE; Joyce, AR; Kim, MM; Mann, AL; Murrelle, EL; Zedler, BK, 2016) |
| "Parents of infants with neonatal abstinence syndrome (NAS) in the NICU may have questions about the long-term consequences of prenatal exposure to methadone, both asked and unasked." | 4.93 | Long-Term Outcomes of Infants with Neonatal Abstinence Syndrome. ( Armstrong, K; Brooks, SS; Clark, L; Cline, GJ; Germain, AM; Maguire, DJ; Shaffer-Hudkins, E; Taylor, S, 2016) |
| "To identify and describe infant deaths presenting suddenly and unexpectedly in whom there was a history of maternal methadone consumption or misuse of drugs during pregnancy." | 3.81 | Maternal use of methadone and risk of sudden neonatal death. ( Cohen, MC; Coombs, RC; Morley, SR, 2015) |
| " This study aims to determine the infant mortality rate of infants born to women on a methadone program during pregnancy and to identify any modifiable risk factors." | 3.76 | Infant mortality among women on a methadone program during pregnancy. ( Burns, L; Conroy, E; Mattick, RP, 2010) |
| " Apnea density and episodes of periodic breathing exceeded the 95th percentile for normal infants in 12 (38%) of 32 of cocaine-exposed infants vs only 1 (6%) of 18 opiate-exposed infants." | 3.67 | Prenatal cocaine exposure is associated with respiratory pattern abnormalities. ( Chasnoff, IJ; Hunt, CE; Kaplan, D; Kletter, R, 1989) |
| "In 50 infants born to women who continued to take heroin during all or part of their pregnancy the drug withdrawal symptoms were mild and were noted in 21 infants (42%)." | 3.67 | Maternal narcotic abuse and the newborn. ( Alroomi, LG; Davidson, J; Evans, TJ; Galea, P; Howat, R, 1988) |
| "Drug addiction during pregnancy has been managed in two ways: the detoxification program and the methadone-maintenance treatment program." | 3.65 | Drug addiction in pregnancy and the neonate. ( Ackerman, BD; Blinick, G; Jerez, E; Wallach, RC, 1976) |
| "RR of SIDS between drug-exposed and control infants." | 2.82 | SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants. ( Makarious, L; Oei, JL; Teng, A, 2022) |
| "The new definition of the term sudden infant death syndrome (SIDS) and the criteria introduced in San Diego for the subclassification of cases have been used to re-classify the first 100 consecutive cases of sudden and unexpected infant deaths that were registered with the German SIDS study (GeSID)." | 1.33 | The San Diego definition of SIDS: practical application and comparison with the GeSID classification. ( Bajanowski, T; Brinkmann, B; Vennemann, M, 2006) |
| "The diagnosis of sudden infant death syndrome (SIDS) is one of exclusion." | 1.31 | Toxicologic analysis in cases of possible sudden infant death syndrome: a worthwhile exercise? ( Ellis, PS; Hulewicz, B; Langlois, NE; Little, D, 2002) |
| "Higher rates of SIDS were found in infants exposed to opiates alone than in cocaine-exposed infants, but increasing rates of SIDS in cocaine-exposed infants toward the end of the decade suggested that "crack" cocaine may be linked to these increasing rates." | 1.29 | Relationship of maternal substance abuse to subsequent sudden infant death syndrome in offspring. ( Davidson, G; Gaines, J; Habel, L; Jessop, D; Kandall, SR, 1993) |
| "This incidence of SIDS was 5." | 1.26 | Sudden unexpected death in infants of narcotic-dependent mothers. ( Falciglia, H; Kandall, SR; Rajegowda, BK, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (50.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Chighine, A | 1 |
| Porcu, M | 1 |
| Ferino, G | 1 |
| Lenigno, N | 1 |
| Trignano, C | 1 |
| d'Aloja, E | 1 |
| Locci, E | 1 |
| Makarious, L | 1 |
| Teng, A | 1 |
| Oei, JL | 1 |
| Cohen, MC | 1 |
| Morley, SR | 1 |
| Coombs, RC | 1 |
| Zedler, BK | 1 |
| Mann, AL | 1 |
| Kim, MM | 1 |
| Amick, HR | 1 |
| Joyce, AR | 1 |
| Murrelle, EL | 1 |
| Jones, HE | 1 |
| Maguire, DJ | 1 |
| Taylor, S | 1 |
| Armstrong, K | 1 |
| Shaffer-Hudkins, E | 1 |
| Germain, AM | 1 |
| Brooks, SS | 1 |
| Cline, GJ | 1 |
| Clark, L | 1 |
| Burns, L | 1 |
| Conroy, E | 1 |
| Mattick, RP | 1 |
| Bajanowski, T | 1 |
| Brinkmann, B | 1 |
| Vennemann, M | 1 |
| Olsen, GD | 1 |
| Lees, MH | 1 |
| Shannon, DC | 1 |
| Kelly, DH | 1 |
| Naeye, RL | 1 |
| Kandall, SR | 2 |
| Gaines, J | 1 |
| Habel, L | 1 |
| Davidson, G | 1 |
| Jessop, D | 1 |
| Langlois, NE | 1 |
| Ellis, PS | 1 |
| Little, D | 1 |
| Hulewicz, B | 1 |
| Rajegowda, BK | 1 |
| Falciglia, H | 1 |
| Blinick, G | 1 |
| Wallach, RC | 1 |
| Jerez, E | 1 |
| Ackerman, BD | 1 |
| Rosen, TS | 1 |
| Johnson, HL | 1 |
| Chasnoff, IJ | 1 |
| Hunt, CE | 1 |
| Kletter, R | 1 |
| Kaplan, D | 1 |
| Alroomi, LG | 1 |
| Davidson, J | 1 |
| Evans, TJ | 1 |
| Galea, P | 1 |
| Howat, R | 1 |
| Ward, SL | 1 |
| Schuetz, S | 1 |
| Kirshna, V | 1 |
| Bean, X | 1 |
| Wingert, W | 1 |
| Wachsman, L | 1 |
| Keens, TG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407] | 55 participants (Actual) | Interventional | 2017-04-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for methadone and Cot Death
| Article | Year |
|---|---|
SIDS is associated with prenatal drug use: a meta-analysis and systematic review of 4 238 685 infants.
Topics: Analgesics, Opioid; Cocaine; Female; Humans; Infant; Methadone; Observational Studies as Topic; Preg | 2022 |
Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Fetal Death; F | 2016 |
Long-Term Outcomes of Infants with Neonatal Abstinence Syndrome.
Topics: Analgesics, Opioid; Child Abuse; Epigenesis, Genetic; Female; Humans; Infant, Newborn; Methadone; Ne | 2016 |
SIDS and near-sids (first of two parts).
Topics: ABO Blood-Group System; Adult; Arrhythmias, Cardiac; Autonomic Nervous System; Birth Order; Brain; C | 1982 |
14 other studies available for methadone and Cot Death
| Article | Year |
|---|---|
Infant urinary metabolomic profile in a fatal acute methadone intoxication.
Topics: Asphyxia; Female; Humans; Infant; Infant, Newborn; Magnetic Resonance Spectroscopy; Metabolomics; Me | 2022 |
Maternal use of methadone and risk of sudden neonatal death.
Topics: Adult; Female; Humans; Infant, Newborn; Male; Methadone; Narcotics; Opioid-Related Disorders; Perina | 2015 |
Infant mortality among women on a methadone program during pregnancy.
Topics: Adult; Female; Humans; Infant Mortality; Infant, Newborn; Live Birth; Medical Record Linkage; Methad | 2010 |
The San Diego definition of SIDS: practical application and comparison with the GeSID classification.
Topics: Age Distribution; Bedding and Linens; California; Child Abuse; Child Development; Forensic Medicine; | 2006 |
Ventilatory response to carbon dioxide of infants following chronic prenatal methadone exposure.
Topics: Carbon Dioxide; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone; Oxygen; Partial | 1980 |
Sudden infant death.
Topics: Adipose Tissue; Adipose Tissue, Brown; Carotid Body; Erythrocytes, Abnormal; Female; Humans; Hypoxia | 1980 |
Relationship of maternal substance abuse to subsequent sudden infant death syndrome in offspring.
Topics: Adult; Age Factors; Chi-Square Distribution; Cocaine; Confidence Intervals; Female; Heroin; Humans; | 1993 |
Toxicologic analysis in cases of possible sudden infant death syndrome: a worthwhile exercise?
Topics: Autopsy; Cause of Death; Diagnostic Tests, Routine; Female; Humans; Infant; Infant, Newborn; Male; M | 2002 |
Sudden unexpected death in infants of narcotic-dependent mothers.
Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Male; Maternal-Fetal | 1978 |
Drug addiction in pregnancy and the neonate.
Topics: Alcoholic Intoxication; Birth Weight; Diazepam; Female; Heroin Dependence; Hospitalization; Humans; | 1976 |
Drug-addicted mothers, their infants, and SIDS.
Topics: Adult; Alcohol Drinking; Cocaine; Developmental Disabilities; Female; Heroin Dependence; Humans; Inf | 1988 |
Prenatal cocaine exposure is associated with respiratory pattern abnormalities.
Topics: Apnea; Cheyne-Stokes Respiration; Cocaine; Female; Humans; Infant, Newborn; Methadone; Pregnancy; Pr | 1989 |
Maternal narcotic abuse and the newborn.
Topics: Adolescent; Adult; Female; Heroin; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinenc | 1988 |
Abnormal sleeping ventilatory pattern in infants of substance-abusing mothers.
Topics: Age Factors; Cocaine; Female; Heart Rate; Heroin; Humans; Infant; Male; Methadone; Narcotics; Phency | 1986 |