methadone has been researched along with Complications, Pregnancy in 487 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " While methadone-maintenance currently is the standard of care for opioid dependence during pregnancy, research suggests that buprenorphine-maintenance may be associated with shorter infant hospital lengths of stay (LOS) relative to methadone-maintenance." | 9.19 | Design considerations for point-of-care clinical trials comparing methadone and buprenorphine treatment for opioid dependence in pregnancy and for neonatal abstinence syndrome. ( Hall, ES; Lewis, D; Marcotte, M; Theobald, J; Van Hook, J; Wexelblatt, SL; Wilder, C; Winhusen, T, 2014) |
| "To compare the profile of signs of neonatal abstinence syndrome (NAS) in methadone- versus buprenorphine-exposed infants." | 9.16 | Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates. ( Arria, AM; Badger, GJ; Coyle, MG; Gaalema, DE; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; Scott, TL; Stine, SM, 2012) |
| "Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy." | 9.14 | Neonatal abstinence syndrome after methadone or buprenorphine exposure. ( Arria, AM; Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Selby, P; Stine, SM, 2010) |
| " Infants born to buprenorphine maintained women are not exposed to a greater proportion of the maternal dose compared with methadone and may be exposed to relatively less of the maternal dose compared with infants born to women maintained on methadone during pregnancy." | 9.14 | (R)- and (S)-methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy. ( Foster, DJ; Gordon, AL; Lopatko, OV; Somogyi, AA; White, JM, 2010) |
| "This study was designed to compare the neonatal abstinence syndrome (NAS) in neonates of methadone and buprenorphine maintained pregnant opioid-dependent women and to provide preliminary safety and efficacy data for a larger multi-center trial." | 9.11 | Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome. ( Chisholm, CA; Choo, RE; Crocetti, M; Dudas, R; Harrow, C; Huestis, MA; Jansson, LM; Jasinski, DR; Johnson, RE; Jones, HE; Lantz, M; Lester, BM; Milio, L; O'Grady, KE, 2005) |
| "To systematically review and meta-analyse studies of neurodevelopmental outcome of children born to mothers prescribed methadone in pregnancy." | 9.01 | Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis. ( Boardman, JP; Chappell, FM; Hamilton, R; Mactier, H; Monnelly, VJ, 2019) |
| "To compare the effects of morphine and methadone on length of hospital stay (LOS) or treatment (LOT) and adverse effects in infants with neonatal abstinence syndrome (NAS)." | 8.98 | Morphine and Methadone for Neonatal Abstinence Syndrome: A Systematic Review. ( Gregory, PJ; Hein, DJ; Risoldi Cochrane, Z; Slowiczek, L, 2018) |
| "A literature search of PubMed (1966 to March 2016) and EMBASE (1973 to March 2016) was completed using the search terms buprenorphine, methadone, pregnancy, opioid, and neonatal abstinence syndrome Priority was given to randomized controlled trials and trials directly comparing buprenorphine and methadone during pregnancy." | 8.93 | Buprenorphine Versus Methadone for Opioid Dependence in Pregnancy. ( Campbell, K; Crannage, E; Forinash, A; Noormohammadi, A; Shyken, J; Yancey, A, 2016) |
| "Buprenorphine and methadone are opioid-receptor agonists used as opioid substitution therapy during pregnancy to limit exposure of the fetus to cycles of opioid withdrawal and reduce the risk of infectious comorbidities of illicit opioid use." | 8.90 | Buprenorphine and methadone for opioid addiction during pregnancy. ( Mozurkewich, EL; Rayburn, WF, 2014) |
| "Many individuals receiving methadone maintenance treatment (MMT) for opioid addiction also require treatment for acute or chronic pain, and the presence of pain is known to have a negative impact on patient health and function." | 8.89 | Chronic and acute pain and pain management for patients in methadone maintenance treatment. ( Eyler, EC, 2013) |
| "This article provides an overview and discussion of the collective maternal, fetal and neonatal outcome research on women maintained on methadone or buprenorphine during pregnancy." | 8.88 | Methadone and buprenorphine for the management of opioid dependence in pregnancy. ( Finnegan, LP; Jones, HE; Kaltenbach, K, 2012) |
| "To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS)." | 8.86 | Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis. ( Clarke, M; Cleary, BJ; Donnelly, J; Fahey, T; Gallagher, PJ; Murphy, DJ; Strawbridge, J, 2010) |
| "Methadone treatment during pregnancy offers overwhelming advantages compared with the less acceptable option of medical detoxification or the unacceptably dangerous option of leaving heroin-addicted women dependent on street drugs." | 8.80 | The methadone-maintained pregnancy. ( Doberczak, TM; Jantunen, M; Kandall, SR; Stein, J, 1999) |
| "Results showed mean reduction in birth weight associated with heroin use: 489 g (95% CI 284-693 g), compared with methadone: 279 g (229-328 g)." | 8.79 | The relationship between maternal use of heroin and methadone and infant birth weight. ( English, DR; Holman, CD; Hulse, GK; Milne, E, 1997) |
| " Illicit drug use during the pregnancy was common in all groups, but in the methadone group it was most common (p = 0." | 8.31 | Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder. ( Kahila, HK; Kanervo, MM; Nikkola, EM; Rantakari, KM; Tupola, SJ, 2023) |
| " In early pregnancy, 10,704 pregnant persons were exposed to buprenorphine and 4387 to methadone." | 8.12 | Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy. ( Bateman, BT; Connery, HS; Davis, JM; Gray, KJ; Hernández-Díaz, S; Huybrechts, KF; Jones, HE; Lester, B; Mogun, H; Straub, L; Suarez, EA; Terplan, M, 2022) |
| "The mainstay of the management of opioid use disorder in pregnancy is with methadone or buprenorphine medication-assisted treatment." | 7.96 | Use of naltrexone in treating opioid use disorder in pregnancy. ( Katz, E; Towers, CV; Visconti, K; Weitz, B, 2020) |
| "To assess safety and effectiveness of transitioning from methadone to buprenorphine when necessary during pregnancy." | 7.88 | Transitioning from methadone to buprenorphine maintenance in management of opioid use disorder during pregnancy. ( Johnson, S; Martin, PR, 2018) |
| "Antenatal exposure to methadone or buprenorphine often causes neonatal abstinence syndrome (NAS) in newborns." | 7.88 | Antenatal methadone vs buprenorphine exposure and length of hospital stay in infants admitted to the intensive care unit with neonatal abstinence syndrome. ( Benjamin, DK; Bennett, MM; Clark, RH; Miller, ES; Murthy, K; Smith, PB; Tolia, VN, 2018) |
| " Factors influencing adherence to buprenorphine during pregnancy have not been identified." | 7.88 | Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence. ( Catlin, D; Coker, JL; Knight, B; Ray-Griffith, S; Stowe, ZN, 2018) |
| "To compare neonatal abstinence syndrome prevalence and characteristics among neonates born to women prescribed buprenorphine and naloxone compared with methadone during pregnancy." | 7.81 | Buprenorphine and naloxone compared with methadone treatment in pregnancy. ( Jones, H; Seashore, C; Stringer, EM; Stuebe, AM; Thorp, J; Wiegand, SL, 2015) |
| "This article aims to describe neonatal outcomes, clinical correlates, and the rate for neonatal abstinence syndrome (NAS) for women on methadone maintenance therapy." | 7.81 | Maternal methadone treatment and neonatal abstinence syndrome. ( Faisal, M; Li, S; Liu, WF; Singh, K, 2015) |
| "To evaluate neonatal abstinence syndrome (NAS) treatment outcomes achieved using an optimized methadone weaning protocol developed using pharmacokinetic (PK) modeling compared with standard methadone weaning." | 7.81 | Cohort Analysis of a Pharmacokinetic-Modeled Methadone Weaning Optimization for Neonatal Abstinence Syndrome. ( Hall, ES; Meinzen-Derr, J; Wexelblatt, SL, 2015) |
| "To evaluate the effectiveness of methadone for the treatment of neonatal abstinence syndrome when used according to a preexisting clinical pathway." | 7.80 | Effectiveness of a clinical pathway with methadone treatment protocol for treatment of neonatal abstinence syndrome following in utero drug exposure to substances of abuse*. ( Bhatt-Mehta, V; Ng, CM; Schumacher, RE, 2014) |
| "In a tertiary neonatal care center in Taiwan, three neonates whose mothers self-reported heroin abuse with methadone treatment during pregnancy were studied." | 7.78 | Perinatal effects of combined use of heroin, methadone, and amphetamine during pregnancy and quantitative measurement of metabolites in hair. ( Chang, YZ; Chen, JY; Chen, SC; Ng, YY; Su, PH; Yang, C, 2012) |
| "To identify maternal and neonatal factors that impact response to methadone therapy for neonatal abstinence syndrome." | 7.77 | Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. ( Akinbi, H; Isemann, B; Meinzen-Derr, J, 2011) |
| "Determine whether infants exposed to chronic maternal methadone with abnormal intrapartum fetal heart rate (FHR) patterns are more likely to require treatment for neonatal abstinence syndrome (NAS)." | 7.77 | Association between intrapartum fetal heart rate patterns and neonatal abstinence syndrome in methadone exposed neonates. ( Albright, B; Brown, SA; Hsi, A; Leeman, LM; Rayburn, WF; Skipper, B, 2011) |
| "05), birth weight, and neonatal morbidities were similar regardless of the maternal methadone dose." | 7.77 | Higher maternal doses of methadone does not increase neonatal abstinence syndrome. ( Bombrys, A; Grier, M; Habli, M; Livingston, J; Pizarro, D; Sibai, B, 2011) |
| "Infants born to drug-misusing mothers prescribed methadone in pregnancy are at risk of a range of visual problems, the underlying causes of which are not clear." | 7.76 | Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy. ( Bradnam, MS; Hamilton, R; MacKinnon, JR; Mactier, H; McGlone, L; Russell, HC, 2010) |
| "To estimate the relationship between maternal methadone dose and the incidence of neonatal abstinence syndrome (NAS)." | 7.76 | Relationship between maternal methadone dose at delivery and neonatal abstinence syndrome. ( Almario, CV; Baxter, JK; Berghella, V; Dysart, KC; Hayes, EJ; Seligman, NS, 2010) |
| "Methadone is standard pharmacotherapy for opioid-dependent pregnant women, yet the relationship between maternal methadone dose and neonatal abstinence syndrome (NAS) severity is still unclear." | 7.76 | Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome. ( Choo, RE; Concheiro, M; Elko, A; Gray, TR; Huestis, MA; Jansson, LM; Jones, HE; Williams, E, 2010) |
| " This study aims to determine the infant mortality rate of infants born to women on a methadone program during pregnancy and to identify any modifiable risk factors." | 7.76 | Infant mortality among women on a methadone program during pregnancy. ( Burns, L; Conroy, E; Mattick, RP, 2010) |
| "Four hundred and fifty singleton pregnancies of drug-misusing women prescribed substitute methadone in pregnancy." | 7.75 | Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources. ( Dryden, C; Hepburn, M; Mactier, H; Young, D, 2009) |
| "Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients." | 7.75 | Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009) |
| "To examine the association between retention in methadone treatment during pregnancy and key neonatal outcomes." | 7.74 | Methadone in pregnancy: treatment retention and neonatal outcomes. ( Burns, L; Lim, K; Mattick, RP; Wallace, C, 2007) |
| "Sixty-eight patients treated with methadone for opiate dependence during pregnancy (vaginal n=35; cesarean n=33) were matched retrospectively to control women." | 7.74 | Intrapartum and postpartum analgesia for women maintained on methadone during pregnancy. ( Benvenuto, A; Howard, D; Meyer, M; Plante, D; Wagner, K, 2007) |
| "Data from this non-randomized comparison suggest that buprenorphine may offer advantages for treatment of opiate dependence during pregnancy." | 7.74 | Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series. ( Heilig, M; Kakko, J; Sarman, I, 2008) |
| "The aim of the study was to analyze the neonatal impact of a methadone maintenance program in pregnancy, and the social resources of the families involved." | 7.73 | Methadone maintenance program in pregnancy in a Swiss perinatal center (II): neonatal outcome and social resources. ( Arlettaz, R; Bucher, HU; Das-Kundu, S; Fauchère, JC; Kashiwagi, M; Lang, A, 2005) |
| "This study assesses the effect of higher doses of methadone during pregnancy on maternal and fetal outcomes." | 7.73 | High-dose methadone maintenance in pregnancy: maternal and neonatal outcomes. ( Anania, B; Leamon, MH; McCarthy, JJ; Parr, MS, 2005) |
| "Measurement of plasma methadone concentration to investigate the rate of clearance of methadone prescribed for heroin dependence in the first, second and third trimesters of pregnancy." | 7.73 | Changes to methadone clearance during pregnancy. ( Boys, A; Hay, A; Raistrick, D; Rostami-Hodjegan, A; Wolff, K, 2005) |
| "To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy." | 7.72 | Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004) |
| "The purpose of this study is to evaluate women receiving methadone maintenance during pregnancy." | 7.70 | Methadone maintenance in pregnancy: a reappraisal. ( Britton, KA; Brizendine, E; Brown, HL; Hiett, AK; Mahaffey, D; Turnquest, MA, 1998) |
| "The authors describe their experience with methadone treatment in pregnancy." | 7.67 | Methadone in pregnancy: clinical-toxicological aspects. ( Chiarotti, M; De Giovanni, N; Falasconi, AM; Offidani, C, 1986) |
| " These two groups were compared with a group of women who had used narcotics in the past and were maintained on methadone during pregnancy, and with a group of drug-free women." | 7.67 | Cocaine use in pregnancy. ( Burns, KA; Burns, WJ; Chasnoff, IJ; Schnoll, SH, 1985) |
| "The course of pregnancy and delivery in 28 women under closely supervised methadone maintenance (group 1) was compared with that of 57 women using heroin or methadone under less controlled circumstances (group 2) and with that of 30 women free of mood-altering medications (group 3)." | 7.65 | Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs. ( Adamsons, K; Stimmel, B, 1976) |
| "A retrospective, inception cohort, nonrandomized control design was employed to evaluate the effects of daily vs twice daily dosing of methadone on opiate/cocaine use, and noncompliance with urine toxicology requests in methadone-maintained pregnant women, n = 45." | 6.68 | Methadone dosing and pregnancy: impact on program compliance. ( DePetrillo, PB; Rice, JM, 1995) |
| " These recommendations address: antepartum issues including treatment, dosage and pharmacological considerations, medical conditions and lab tests, intrapartum issues, postpartum concerns including breastfeeding, neonatal withdrawal, and developmental effects associated with methadone." | 6.41 | Clinical management of methadone dependence during pregnancy. ( Curet, LB; Dorato, V; Wallerstedt, C; Wilbourne, P, 2001) |
| "Weight loss was less in small for gestational age compared to appropriately grown infants (p<0." | 5.38 | Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding. ( Campbell, N; Dryden, C; Mactier, H; Young, D, 2012) |
| "Methadone maintenance treatment (MMT) is the standard treatment of choice for pregnant opiate addicts; however, data on newborn outcomes are contradictory." | 5.38 | Duration of methadone maintenance treatment during pregnancy and pregnancy outcome parameters in women with opiate addiction. ( Adelson, M; Bloch, M; Dollberg, S; Peles, E; Schreiber, S, 2012) |
| "Pregnancy care for these women needs to continue to develop to improve overall outcomes." | 5.38 | Maternal and neonatal outcomes following methadone substitution during pregnancy. ( Ash, A; Douiri, A; Greig, E, 2012) |
| " Maternal opiate dosing has been investigated with conflicting results." | 5.36 | Perinatal risk factors for the neonatal abstinence syndrome in infants born to women on methadone maintenance therapy. ( Cook, CM; Jones, MP; Liu, AJ; Murray, H; Nanan, R, 2010) |
| "Methadone levels were kept blinded from clinicians." | 5.31 | Methadone trough levels in pregnancy. ( Berghella, V; Drozdick, J; Hill, M; Kaltenbach, K, 2002) |
| "Traditionally, methadone maintenance therapy has been a once-daily dosing schedule." | 5.30 | Alterations in methadone metabolism during late pregnancy. ( Jarvis, MA; Kniseley, JS; Schnoll, SH; Wu-Pong, S, 1999) |
| " Methadone plasma concentration-time data were fit to a one-compartment pharmacokinetic model by extended least-squares regression." | 5.28 | Altered methadone pharmacokinetics in pregnancy: implications for dosing. ( Camara, P; DePetrillo, P; Dudley, M; Griffiths, W; Swift, RM, 1989) |
| "Newborns who are prenatally exposed to methadone are at risk for neonatal abstinence syndrome and the associated excess weight loss and poor weight gain." | 5.27 | Randomized Clinical Trial of Standard- Versus High-Calorie Formula for Methadone-Exposed Infants: A Feasibility Study. ( Baker, R; Bogen, DL; Cohlan, B; Hanusa, BH; Medoff-Cooper, B, 2018) |
| "Methadone and buprenorphine are recommended to treat opioid use disorders during pregnancy." | 5.27 | Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes. ( Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Salisbury, AL; Stine, S, 2018) |
| " While methadone-maintenance currently is the standard of care for opioid dependence during pregnancy, research suggests that buprenorphine-maintenance may be associated with shorter infant hospital lengths of stay (LOS) relative to methadone-maintenance." | 5.19 | Design considerations for point-of-care clinical trials comparing methadone and buprenorphine treatment for opioid dependence in pregnancy and for neonatal abstinence syndrome. ( Hall, ES; Lewis, D; Marcotte, M; Theobald, J; Van Hook, J; Wexelblatt, SL; Wilder, C; Winhusen, T, 2014) |
| "Induction onto buprenorphine during pregnancy may be more challenging than induction onto methadone." | 5.17 | Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention. ( Coyle, MG; Fischer, G; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; Stine, SM, 2013) |
| "To identify factors that predict the expression of neonatal abstinence syndrome (NAS) in infants exposed to methadone or buprenorphine in utero." | 5.16 | Predicting treatment for neonatal abstinence syndrome in infants born to women maintained on opioid agonist medication. ( Coyle, MG; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; Salisbury, AL; Stine, SM, 2012) |
| "To compare the profile of signs of neonatal abstinence syndrome (NAS) in methadone- versus buprenorphine-exposed infants." | 5.16 | Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates. ( Arria, AM; Badger, GJ; Coyle, MG; Gaalema, DE; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; Scott, TL; Stine, SM, 2012) |
| "Buprenorphine appears to have an acceptable safety profile for use during pregnancy." | 5.16 | Infections and obstetric outcomes in opioid-dependent pregnant women maintained on methadone or buprenorphine. ( Baxter, JK; Coyle, MG; Heil, SH; Holbrook, AM; Jones, HE; Kaltenbach, K; Martin, PR; Stine, SM, 2012) |
| " Methadone maintenance yielded to a significantly higher neonatal birth weight." | 5.15 | Randomized controlled trials in pregnancy: scientific and ethical aspects. Exposure to different opioid medications during pregnancy in an intra-individual comparison. ( Arria, A; Aschauer, C; Bäwert, A; Fischer, G; Jagsch, R; Jones, H; Leitich, H; Rohrmeister, K; Unger, A; Winklbaur, B, 2011) |
| "In order to investigate the effects of exposure to buprenorphine compared with methadone during pregnancy, a prospective multicenter study was conducted in collaboration with maternity hospitals, maintenance therapy centers, and general practitioners involved in addiction care." | 5.15 | Buprenorphine versus methadone in pregnant opioid-dependent women: a prospective multicenter study. ( Berrebi, A; Chaumerliac, C; Damase-Michel, C; Garipuy, D; Hammou, Y; Lacroix, I; Lapeyre-Mestre, M; Montastruc, JL; Schmitt, L, 2011) |
| "One hundred and fourteen subjects were included in the analysis, with 77 in SP (n = 51 methadone, n = 26 buprenorphine), and 37 in CT (n = 19 methadone, n = 18 buprenorphine), comparing maternal concomitant consumption during third trimester, demographic birth data, duration of treatment for neonatal abstinence syndrome (NAS), morphine dose for NAS treatment and length of hospital stay (LOS)." | 5.15 | Impact of treatment approach on maternal and neonatal outcome in pregnant opioid-maintained women. ( Aschauer, C; Ebner, N; Fischer, G; Jagsch, R; Metz, V; Pribasnig, A; Würzl, J, 2011) |
| "This was a secondary analysis of data collected in a prospective randomized, double-blind, double-dummy, multicenter trial (MOTHER study) that examined the comparative safety and efficacy of methadone and buprenorphine during pregnancy." | 5.15 | Are male neonates more vulnerable to neonatal abstinence syndrome than female neonates? ( Bäwert, A; Coyle, M; Fischer, G; Jagsch, R; Martin, PR; Rohrmeister, K; Unger, A; Winklbaur, B, 2011) |
| "Daily methadone maintenance is the standard of care for opiate dependency during pregnancy." | 5.14 | Maternal methadone dosing schedule and fetal neurobehaviour. ( Dipietro, JA; Elko, A; Jansson, LM; Kivlighan, KT; Knauer, H; Velez, M, 2009) |
| "Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy." | 5.14 | Neonatal abstinence syndrome after methadone or buprenorphine exposure. ( Arria, AM; Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Selby, P; Stine, SM, 2010) |
| " Infants born to buprenorphine maintained women are not exposed to a greater proportion of the maternal dose compared with methadone and may be exposed to relatively less of the maternal dose compared with infants born to women maintained on methadone during pregnancy." | 5.14 | (R)- and (S)-methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy. ( Foster, DJ; Gordon, AL; Lopatko, OV; Somogyi, AA; White, JM, 2010) |
| "Eighteen women were assigned randomly to receive either methadone (n = 9) or buprenorphine (n = 9) during weeks 24-29 of pregnancy." | 5.12 | Methadone versus buprenorphine in pregnant addicts: a double-blind, double-dummy comparison study. ( Aschauer, H; Baewert, A; Fischer, G; Jagsch, R; Langer, M; Ortner, R; Rohrmeister, K, 2006) |
| " The mothers received methadone (n=22), slow-release oral morphine (n=17) or buprenorphine (n=14) throughout pregnancy." | 5.12 | Management of neonatal abstinence syndrome in neonates born to opioid maintained women. ( Baewert, A; Ebner, N; Fischer, G; Jagsch, R; Peternell, A; Rohrmeister, K; Thau, K; Winklbaur, B, 2007) |
| "This study was designed to compare the neonatal abstinence syndrome (NAS) in neonates of methadone and buprenorphine maintained pregnant opioid-dependent women and to provide preliminary safety and efficacy data for a larger multi-center trial." | 5.11 | Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome. ( Chisholm, CA; Choo, RE; Crocetti, M; Dudas, R; Harrow, C; Huestis, MA; Jansson, LM; Jasinski, DR; Johnson, RE; Jones, HE; Lantz, M; Lester, BM; Milio, L; O'Grady, KE, 2005) |
| "To systematically review and meta-analyse studies of neurodevelopmental outcome of children born to mothers prescribed methadone in pregnancy." | 5.01 | Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis. ( Boardman, JP; Chappell, FM; Hamilton, R; Mactier, H; Monnelly, VJ, 2019) |
| "To compare the effects of morphine and methadone on length of hospital stay (LOS) or treatment (LOT) and adverse effects in infants with neonatal abstinence syndrome (NAS)." | 4.98 | Morphine and Methadone for Neonatal Abstinence Syndrome: A Systematic Review. ( Gregory, PJ; Hein, DJ; Risoldi Cochrane, Z; Slowiczek, L, 2018) |
| "This study examined the obstetric health of opioid-dependent women who were treated with implant naltrexone during pregnancy, and compared them with women treated with methadone and/or buprenorphine and a cohort of non-opioid-dependent controls." | 4.95 | A Retrospective Cohort Study of Obstetric Outcomes in Opioid-Dependent Women Treated with Implant Naltrexone, Oral Methadone or Sublingual Buprenorphine, and Non-Dependent Controls. ( Hulse, G; Kelty, E, 2017) |
| "A literature search of PubMed (1966 to March 2016) and EMBASE (1973 to March 2016) was completed using the search terms buprenorphine, methadone, pregnancy, opioid, and neonatal abstinence syndrome Priority was given to randomized controlled trials and trials directly comparing buprenorphine and methadone during pregnancy." | 4.93 | Buprenorphine Versus Methadone for Opioid Dependence in Pregnancy. ( Campbell, K; Crannage, E; Forinash, A; Noormohammadi, A; Shyken, J; Yancey, A, 2016) |
| "Moderately strong evidence indicates lower risk of preterm birth, greater birth weight and larger head circumference with buprenorphine treatment of maternal opioid use disorder during pregnancy compared with methadone treatment, and no greater harms." | 4.93 | Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child. ( Amick, HR; Jones, HE; Joyce, AR; Kim, MM; Mann, AL; Murrelle, EL; Zedler, BK, 2016) |
| "Parents of infants with neonatal abstinence syndrome (NAS) in the NICU may have questions about the long-term consequences of prenatal exposure to methadone, both asked and unasked." | 4.93 | Long-Term Outcomes of Infants with Neonatal Abstinence Syndrome. ( Armstrong, K; Brooks, SS; Clark, L; Cline, GJ; Germain, AM; Maguire, DJ; Shaffer-Hudkins, E; Taylor, S, 2016) |
| "Buprenorphine and methadone are opioid-receptor agonists used as opioid substitution therapy during pregnancy to limit exposure of the fetus to cycles of opioid withdrawal and reduce the risk of infectious comorbidities of illicit opioid use." | 4.90 | Buprenorphine and methadone for opioid addiction during pregnancy. ( Mozurkewich, EL; Rayburn, WF, 2014) |
| "The present paper considers naltrexone to treat opioid dependence during pregnancy." | 4.89 | Naltrexone in the treatment of opioid-dependent pregnant women: the case for a considered and measured approach to research. ( Chisolm, MS; Jansson, LM; Jones, HE; Terplan, M, 2013) |
| "Many individuals receiving methadone maintenance treatment (MMT) for opioid addiction also require treatment for acute or chronic pain, and the presence of pain is known to have a negative impact on patient health and function." | 4.89 | Chronic and acute pain and pain management for patients in methadone maintenance treatment. ( Eyler, EC, 2013) |
| "This article provides an overview and discussion of the collective maternal, fetal and neonatal outcome research on women maintained on methadone or buprenorphine during pregnancy." | 4.88 | Methadone and buprenorphine for the management of opioid dependence in pregnancy. ( Finnegan, LP; Jones, HE; Kaltenbach, K, 2012) |
| "While buprenorphine produces a less severe neonatal abstinence syndrome than methadone, both methadone and buprenorphine are important parts of a complete comprehensive treatment approach for opioid-dependent pregnant women." | 4.88 | Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review. ( Arria, AM; Baewert, A; Coyle, MG; Fischer, G; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; Selby, P; Stine, SM, 2012) |
| "After completing this CME activity, physicians should be better able to assess the treatment options available to patients with opioid addiction during pregnancy, compare the risk/safety profiles of methadone and buprenorphine, and evaluate the recommendations and current data surrounding breast-feeding while on opioid maintenance treatment." | 4.88 | Opioid addiction in pregnancy. ( Lee-Parritz, A; Saia, K; Shainker, SA, 2012) |
| "To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS)." | 4.86 | Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis. ( Clarke, M; Cleary, BJ; Donnelly, J; Fahey, T; Gallagher, PJ; Murphy, DJ; Strawbridge, J, 2010) |
| " First, women who continued to use illicit heroin throughout pregnancy; secondly, women stabilized on methadone at the time of conception or shortly after and thirdly, women who use heroin well into pregnancy with late entry into methadone treatment, or who continued to use illicit heroin during pregnancy while receiving methadone." | 4.80 | Assessing the relationship between maternal opiate use and neonatal mortality. ( English, DR; Holman, CD; Hulse, GK; Milne, E, 1998) |
| "Methadone treatment during pregnancy offers overwhelming advantages compared with the less acceptable option of medical detoxification or the unacceptably dangerous option of leaving heroin-addicted women dependent on street drugs." | 4.80 | The methadone-maintained pregnancy. ( Doberczak, TM; Jantunen, M; Kandall, SR; Stein, J, 1999) |
| "Results showed mean reduction in birth weight associated with heroin use: 489 g (95% CI 284-693 g), compared with methadone: 279 g (229-328 g)." | 4.79 | The relationship between maternal use of heroin and methadone and infant birth weight. ( English, DR; Holman, CD; Hulse, GK; Milne, E, 1997) |
| " Illicit drug use during the pregnancy was common in all groups, but in the methadone group it was most common (p = 0." | 4.31 | Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder. ( Kahila, HK; Kanervo, MM; Nikkola, EM; Rantakari, KM; Tupola, SJ, 2023) |
| "Of 400 eligible pregnancies, 85 and 137 individuals received buprenorphine and methadone, respectively, during early pregnancy." | 4.31 | Comparative Safety Analysis of Opioid Agonist Treatment in Pregnant Women with Opioid Use Disorder: A Population-Based Study. ( Brothers, TN; Hartzema, A; Lewkowitz, AK; Meador, KJ; Pawasauskas, J; Quilliam, BJ; Wang, S; Ward, KE; Wen, X, 2023) |
| " Research consistently demonstrates the efficacy of medications for OUD (MOUD); however, researchers have called for additional studies evaluating the safety of MOUD during pregnancy, particularly the relative safety of two commonly used MOUD medications-methadone and buprenorphine." | 4.12 | A retrospective, observational study on medication for opioid use disorder during pregnancy and risk for neonatal abstinence syndrome. ( Aujla, R; Boyars, L; Cleary, E; Douglas, E; Guille, C; Smith, C; Sujan, A, 2022) |
| " In early pregnancy, 10,704 pregnant persons were exposed to buprenorphine and 4387 to methadone." | 4.12 | Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy. ( Bateman, BT; Connery, HS; Davis, JM; Gray, KJ; Hernández-Díaz, S; Huybrechts, KF; Jones, HE; Lester, B; Mogun, H; Straub, L; Suarez, EA; Terplan, M, 2022) |
| " Treatment with buprenorphine-naloxone (compared with methadone) reduced odds of each outcome including neonatal abstinence syndrome (adjusted odds ratio: 0." | 4.02 | Opioid Use Disorder and Perinatal Outcomes. ( Homayra, F; Marchand, C; Mead, A; Min, JE; Ng, J; Nosyk, B; Piske, M; Woolner, M; Zhou, H, 2021) |
| "Medications for opioid use disorder, including methadone, combined with comprehensive wraparound services, are the gold standard for treatment in pregnancy." | 4.02 | Racial inequity in methadone dose at delivery in pregnant women with opioid use disorder. ( Abatemarco, DJ; Barber, C; Baxter, JK; Cruz, Y; Hand, DJ; Roman, AR; Rosenthal, EW; Short, VL, 2021) |
| "Pregnant smokers recruited to participate in a placebo-controlled trial of bupropion for smoking cessation provided a blood sample for measurement of NMR." | 3.96 | Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study. ( Hand, D; Kranzler, HR; Lynch, KG; Oncken, C; Schnoll, R; Tyndale, RF; Washio, Y; Zindel, LR, 2020) |
| " Furthermore, buprenorphine is associated with milder symptoms of neonatal abstinence syndrome (NAS) compared with methadone." | 3.96 | Prevalence and Geographic Distribution of Obstetrician-Gynecologists Who Treat Medicaid Enrollees and Are Trained to Prescribe Buprenorphine. ( Culhane, J; Meisel, ZF; Nguemeni Tiako, MJ; South, E; Srinivas, SK, 2020) |
| "The mainstay of the management of opioid use disorder in pregnancy is with methadone or buprenorphine medication-assisted treatment." | 3.96 | Use of naltrexone in treating opioid use disorder in pregnancy. ( Katz, E; Towers, CV; Visconti, K; Weitz, B, 2020) |
| "There is lack of knowledge about the safety of treatment with methadone and buprenorphine as part of opioid maintenance treatment (OMT) during pregnancy." | 3.91 | Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway. ( Engeland, A; Gabrhelík, R; Handal, M; Lund, IO; Mravčík, V; Nechanská, B; Skurtveit, S, 2019) |
| "To estimate whether methadone, buprenorphine, or detoxification treatment is the most cost-effective approach to the management of opioid use disorder (OUD) during pregnancy." | 3.91 | Methadone, Buprenorphine, or Detoxification for Management of Perinatal Opioid Use Disorder: A Cost-Effectiveness Analysis. ( Grobman, WA; Miller, ES; Premkumar, A; Terplan, M, 2019) |
| "To assess safety and effectiveness of transitioning from methadone to buprenorphine when necessary during pregnancy." | 3.88 | Transitioning from methadone to buprenorphine maintenance in management of opioid use disorder during pregnancy. ( Johnson, S; Martin, PR, 2018) |
| "Antenatal exposure to methadone or buprenorphine often causes neonatal abstinence syndrome (NAS) in newborns." | 3.88 | Antenatal methadone vs buprenorphine exposure and length of hospital stay in infants admitted to the intensive care unit with neonatal abstinence syndrome. ( Benjamin, DK; Bennett, MM; Clark, RH; Miller, ES; Murthy, K; Smith, PB; Tolia, VN, 2018) |
| "Two national cohorts of women receiving opioid maintenance treatment during pregnancy showed small but not statistically significant differences in neonatal outcomes in favour of buprenorphine compared with methadone." | 3.88 | Neonatal outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway. ( Engeland, A; Gabrhelík, R; Handal, M; Lund, IO; Mravčík, V; Nechanská, B; Skurtveit, S, 2018) |
| " Factors influencing adherence to buprenorphine during pregnancy have not been identified." | 3.88 | Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence. ( Catlin, D; Coker, JL; Knight, B; Ray-Griffith, S; Stowe, ZN, 2018) |
| "The use of implant naltrexone during pregnancy was not associated with higher rates of negative birth outcomes compared with methadone- and buprenorphine-exposed neonates." | 3.85 | A Retrospective Cohort Study of Birth Outcomes in Neonates Exposed to Naltrexone in Utero: A Comparison with Methadone-, Buprenorphine- and Non-opioid-Exposed Neonates. ( Hulse, G; Kelty, E, 2017) |
| "To report the presentation and characteristics of strabismus in children with prenatal methadone exposure." | 3.85 | Sensorimotor outcomes in children with prenatal exposure to methadone. ( Jansson, LM; Park, HJ; Yoo, SH, 2017) |
| "In this cohort, women taking ≥60mg of methadone during pregnancy were more likely to remain in treatment and to provide urine samples negative for illicit drugs." | 3.85 | Association of methadone dose with substance use and treatment retention in pregnant and postpartum women with opioid use disorder. ( Hosta, D; Wilder, CM; Winhusen, T, 2017) |
| "Maternal buprenorphine maintenance predisposes the infant to exhibit neonatal abstinence syndrome (NAS), but there is insufficient published information regarding the nature of NAS and factors that contribute to its severity in buprenorphine-exposed infants." | 3.85 | Maternal buprenorphine treatment and infant outcome. ( DiPietro, JA; Gandotra, N; Jansson, LM; Jones, H; King, VL; McConnell, K; Millio, L; Rios, R; Spencer, N; Tuten, M; Velez, ML, 2017) |
| " The standard of care for pregnant women with opioid use disorder is opioid maintenance therapy including either methadone or buprenorphine, which can be initiated at any time during pregnancy." | 3.85 | Delayed villous maturation in term placentas exposed to opioid maintenance therapy: a retrospective cohort study. ( Caritis, SN; Catov, JM; Lemon, LS; Mokhtari, NB; Parks, WT; Serra, AE; Venkataramanan, R, 2017) |
| "Using the retrospective matched cohort study design, 396 births to women on methadone treatment during pregnancy (the methadone-treated group) and 609 to women who started methadone treatment after childbirth (the heroin-exposed group) were identified in the National Methadone Maintenance Program." | 3.81 | Comparison of adverse obstetric outcomes and maternity hospitalization among heroin-exposed and methadone-treated women in Taiwan. ( Chen, CY; Ho, IK; Lien, YT; Su, LW; Yeh, HH, 2015) |
| "To compare neonatal abstinence syndrome prevalence and characteristics among neonates born to women prescribed buprenorphine and naloxone compared with methadone during pregnancy." | 3.81 | Buprenorphine and naloxone compared with methadone treatment in pregnancy. ( Jones, H; Seashore, C; Stringer, EM; Stuebe, AM; Thorp, J; Wiegand, SL, 2015) |
| "This article aims to describe neonatal outcomes, clinical correlates, and the rate for neonatal abstinence syndrome (NAS) for women on methadone maintenance therapy." | 3.81 | Maternal methadone treatment and neonatal abstinence syndrome. ( Faisal, M; Li, S; Liu, WF; Singh, K, 2015) |
| "Pregnant women filling at least one prescription for an opioid analgesic at any time during pregnancy for whom opioid exposure characteristics including duration of therapy: short term (<30 days) or long term (≥ 30 days); timing of use: early use (only in the first two trimesters) or late use (extending into the third trimester); and cumulative dose (in morphine equivalent milligrams) were assessed." | 3.81 | Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study. ( Bateman, BT; Desai, RJ; Hernandez-Diaz, S; Huybrechts, KF; Kaltenbach, K; Kerzner, LS; Mogun, H; Patorno, E, 2015) |
| "To describe obstetrical and neonatal outcomes including neonatal abstinence syndrome (NAS) in a Canadian cohort of methadone-maintained pregnant women." | 3.81 | Obstetrical and neonatal outcomes of methadone-maintained pregnant women: a canadian multisite cohort study. ( Abrahams, R; Graves, L; Kahan, M; Kim, T; Ordean, A, 2015) |
| "To evaluate neonatal abstinence syndrome (NAS) treatment outcomes achieved using an optimized methadone weaning protocol developed using pharmacokinetic (PK) modeling compared with standard methadone weaning." | 3.81 | Cohort Analysis of a Pharmacokinetic-Modeled Methadone Weaning Optimization for Neonatal Abstinence Syndrome. ( Hall, ES; Meinzen-Derr, J; Wexelblatt, SL, 2015) |
| "To evaluate the effectiveness of methadone for the treatment of neonatal abstinence syndrome when used according to a preexisting clinical pathway." | 3.80 | Effectiveness of a clinical pathway with methadone treatment protocol for treatment of neonatal abstinence syndrome following in utero drug exposure to substances of abuse*. ( Bhatt-Mehta, V; Ng, CM; Schumacher, RE, 2014) |
| "In infants of methadone-prescribed opioid-dependent mothers mean birth weight was 259 g [95% confidence interval (CI) 214-303 g; P<0." | 3.80 | Reduced fetal growth in methadone-maintained pregnancies is not fully explained by smoking or socio-economic deprivation. ( Dryden, C; Mactier, H; Shipton, D; Tappin, DM, 2014) |
| "To describe the prevalence of in utero alcohol and illicit drug exposure in infants born to mothers prescribed methadone in pregnancy, and to compare the accuracy of maternal interview with infant toxicology." | 3.79 | In utero drug and alcohol exposure in infants born to mothers prescribed maintenance methadone. ( Cooper, G; Hassan, H; Mactier, H; McGlone, L, 2013) |
| "Limited pharmacological data are available to guide methadone treatment during pregnancy and postpartum." | 3.79 | Pharmacologic evidence to support clinical decision making for peripartum methadone treatment. ( Bogen, DL; Friedman, CR; Hanusa, BH; Helsel, JC; Nukui, T; Perel, JM; Romkes, M; Wisner, KL, 2013) |
| "This study aimed to (i) describe methadone dosing before, during and after pregnancy, (ii) to compare the incidence of neonatal abstinence syndrome (NAS) between those with dose decreases and those with steady or increasing doses and (iii) to describe prescribed medication use among opioid-dependent pregnant women." | 3.79 | Methadone dosing and prescribed medication use in a prospective cohort of opioid-dependent pregnant women. ( Carmody, D; Clarke, T; Cleary, BJ; Eogan, M; Fahey, T; Gallagher, PJ; Gleeson, J; McDermott, C; Murphy, DJ; O'Connell, MP; O'Sullivan, A; Reynolds, K; White, MJ, 2013) |
| " For opiate-addicted pregnant women, methadone is the treatment of choice and should be maintained throughout pregnancy, despite the manageable problem of neonatal opiate withdrawal." | 3.79 | Management of the pregnant substance abusing woman. ( Sheehan, M; Sheehan, MG, 2013) |
| "Pregnant women in methadone maintenance therapy may have poor nutrition during pregnancy." | 3.78 | A pilot study of the nutritional status of opiate-using pregnant women on methadone maintenance therapy. ( Bodnar, LM; Bogen, DL; Hanusa, BH; Tomedi, LE; Wisner, KL, 2012) |
| " Methadone use in pregnancy has been associated with adverse perinatal outcomes and neonatal abstinence syndrome (NAS)." | 3.78 | Methadone and perinatal outcomes: a prospective cohort study. ( Carmody, D; Clarke, T; Cleary, BJ; Eogan, M; Fahey, T; Gallagher, PJ; Gleeson, J; McDermott, C; Murphy, DJ; O'Connell, MP; O'Sullivan, A; White, MJ, 2012) |
| "One hundred fifty-two opioid-dependent pregnant women on methadone maintenance therapy (MMT) (n = 136) or buprenorphine maintenance therapy (BMT) (n = 16) during pregnancy and their neonates." | 3.78 | Opioid dependency in pregnancy and length of stay for neonatal abstinence syndrome. ( Hayes, MJ; Paul, JA; Pritham, UA, 2012) |
| "In a tertiary neonatal care center in Taiwan, three neonates whose mothers self-reported heroin abuse with methadone treatment during pregnancy were studied." | 3.78 | Perinatal effects of combined use of heroin, methadone, and amphetamine during pregnancy and quantitative measurement of metabolites in hair. ( Chang, YZ; Chen, JY; Chen, SC; Ng, YY; Su, PH; Yang, C, 2012) |
| "To identify maternal and neonatal factors that impact response to methadone therapy for neonatal abstinence syndrome." | 3.77 | Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome. ( Akinbi, H; Isemann, B; Meinzen-Derr, J, 2011) |
| "Determine whether infants exposed to chronic maternal methadone with abnormal intrapartum fetal heart rate (FHR) patterns are more likely to require treatment for neonatal abstinence syndrome (NAS)." | 3.77 | Association between intrapartum fetal heart rate patterns and neonatal abstinence syndrome in methadone exposed neonates. ( Albright, B; Brown, SA; Hsi, A; Leeman, LM; Rayburn, WF; Skipper, B, 2011) |
| "05), birth weight, and neonatal morbidities were similar regardless of the maternal methadone dose." | 3.77 | Higher maternal doses of methadone does not increase neonatal abstinence syndrome. ( Bombrys, A; Grier, M; Habli, M; Livingston, J; Pizarro, D; Sibai, B, 2011) |
| " Growth restriction was independent of the last maternal methadone dose and the cumulative methadone dose during pregnancy." | 3.76 | Growth restriction in pregnancies of opioid-dependent mothers. ( Cook, CM; Jones, MP; Liu, AJ; Nanan, R; Sithamparanathan, S, 2010) |
| "Infants born to drug-misusing mothers prescribed methadone in pregnancy are at risk of a range of visual problems, the underlying causes of which are not clear." | 3.76 | Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy. ( Bradnam, MS; Hamilton, R; MacKinnon, JR; Mactier, H; McGlone, L; Russell, HC, 2010) |
| "To estimate the relationship between maternal methadone dose and the incidence of neonatal abstinence syndrome (NAS)." | 3.76 | Relationship between maternal methadone dose at delivery and neonatal abstinence syndrome. ( Almario, CV; Baxter, JK; Berghella, V; Dysart, KC; Hayes, EJ; Seligman, NS, 2010) |
| "Methadone is standard pharmacotherapy for opioid-dependent pregnant women, yet the relationship between maternal methadone dose and neonatal abstinence syndrome (NAS) severity is still unclear." | 3.76 | Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome. ( Choo, RE; Concheiro, M; Elko, A; Gray, TR; Huestis, MA; Jansson, LM; Jones, HE; Williams, E, 2010) |
| " This study aims to determine the infant mortality rate of infants born to women on a methadone program during pregnancy and to identify any modifiable risk factors." | 3.76 | Infant mortality among women on a methadone program during pregnancy. ( Burns, L; Conroy, E; Mattick, RP, 2010) |
| "Four hundred and fifty singleton pregnancies of drug-misusing women prescribed substitute methadone in pregnancy." | 3.75 | Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources. ( Dryden, C; Hepburn, M; Mactier, H; Young, D, 2009) |
| " This study investigated whether maternal methadone/buprenorphine dose and nicotine use in pregnancy affects the occurrence and duration of neonatal abstinence syndrome (NAS) in the infant." | 3.75 | Opioid maintenance treatment during pregnancy: occurrence and severity of neonatal abstinence syndrome. A national prospective study. ( Bakstad, B; Ravndal, E; Sarfi, M; Welle-Strand, GK, 2009) |
| "Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients." | 3.75 | Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009) |
| "Retrospective cohort study of 232 metropolitan and 67 rural infants born to mothers maintained on methadone throughout pregnancy for the treatment of opiate dependency, between January 2000 and December 2006." | 3.75 | Pregnancy and neonatal characteristics of opioid-dependent Indigenous Australians: a rural and metropolitan comparison. ( An, EI; Canalese, J; Liu, AJ; Nanan, R; Tetstall, E, 2009) |
| " Maternal and neonatal outcomes were evaluated, including cholestasis of pregnancy, preterm birth, low birth weight, neonatal intensive care unit admissions, and neonatal methadone withdrawal." | 3.74 | Chronic hepatitis C in pregnancy. ( Arora, S; Berkley, EM; Dunkelberg, JC; Leslie, KK; Qualls, C, 2008) |
| " Use of heroin alone during pregnancy was recorded in 51 women (50%), methadone alone in 6 (7%), and a combination of heroin and methadone in 9 (11%)." | 3.74 | Maternal and neonatal effects of substance abuse during pregnancy: our ten-year experience. ( Banovic, I; Bucat, M; Capkun, V; Roje, D; Vucinovic, M; Vucinovic, Z, 2008) |
| "To examine the association between retention in methadone treatment during pregnancy and key neonatal outcomes." | 3.74 | Methadone in pregnancy: treatment retention and neonatal outcomes. ( Burns, L; Lim, K; Mattick, RP; Wallace, C, 2007) |
| "Sixty-eight patients treated with methadone for opiate dependence during pregnancy (vaginal n=35; cesarean n=33) were matched retrospectively to control women." | 3.74 | Intrapartum and postpartum analgesia for women maintained on methadone during pregnancy. ( Benvenuto, A; Howard, D; Meyer, M; Plante, D; Wagner, K, 2007) |
| "The objective of this study was to determine the population prevalence and correlates of neonatal abstinence syndrome among neonates born to women on methadone, using a cross-sectional analysis of linked population health data." | 3.74 | Using population data to examine the prevalence and correlates of neonatal abstinence syndrome. ( Burns, L; Mattick, RP, 2007) |
| "We selected 32 women in the city of Vancouver known to have used heroin or methadone during pregnancy between October 2001 and December 2002." | 3.74 | Rooming-in compared with standard care for newborns of mothers using methadone or heroin. ( Abrahams, RR; Janssen, PA; Kelly, SA; Mackintosh, J; Payne, S; Thiessen, PN, 2007) |
| "Statistically birth weight of newborns was significantly lowest in the group of heroin-addicted women as compared to the group receiving substitution with buprenorphine p<0." | 3.74 | [The effect of substitution therapy on the birth weight of the newborn, its postpartum adaptation, trophic and course of the neonatal abstinence syndrome]. ( Binder, T; Vavrinková, B, 2007) |
| "To assess potential risks related to the duration or total amount of fetal methadone exposure during gestation, we compared babies of women who conceived and maintained on methadone throughout pregnancy with babies of women who began methadone treatment during the second or third trimester." | 3.74 | Outcomes of neonates conceived on methadone maintenance therapy. ( Biles, LA; Leamon, MH; McCarthy, JJ; Stenson, G, 2008) |
| "Data from this non-randomized comparison suggest that buprenorphine may offer advantages for treatment of opiate dependence during pregnancy." | 3.74 | Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series. ( Heilig, M; Kakko, J; Sarman, I, 2008) |
| "Although methadone maintenance is the standard treatment of opiate addiction in pregnancy, opinion as to its utility is divided." | 3.73 | Methadone maintenance program in a Swiss perinatal center: (I): Management and outcome of 89 pregnancies. ( Arlettaz, R; Hebisch, G; Kashiwagi, M; Lauper, U; Zimmermann, R, 2005) |
| "The aim of the study was to analyze the neonatal impact of a methadone maintenance program in pregnancy, and the social resources of the families involved." | 3.73 | Methadone maintenance program in pregnancy in a Swiss perinatal center (II): neonatal outcome and social resources. ( Arlettaz, R; Bucher, HU; Das-Kundu, S; Fauchère, JC; Kashiwagi, M; Lang, A, 2005) |
| "This study assesses the effect of higher doses of methadone during pregnancy on maternal and fetal outcomes." | 3.73 | High-dose methadone maintenance in pregnancy: maternal and neonatal outcomes. ( Anania, B; Leamon, MH; McCarthy, JJ; Parr, MS, 2005) |
| " Women who took heroin in later pregnancy were significantly more likely than women who were stabilised on methadone to have a baby who needed morphine (40% versus 19%), had higher mean maximum neonatal abstinence scores (NAS) (5." | 3.73 | Pregnancy outcome in women who use opiates. ( Armstrong, D; Fajemirokun-Odudeyi, O; Lindow, SW; Pairaudeau, P; Phillips, T; Sinha, C; Tutty, S, 2006) |
| "Measurement of plasma methadone concentration to investigate the rate of clearance of methadone prescribed for heroin dependence in the first, second and third trimesters of pregnancy." | 3.73 | Changes to methadone clearance during pregnancy. ( Boys, A; Hay, A; Raistrick, D; Rostami-Hodjegan, A; Wolff, K, 2005) |
| "To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy." | 3.72 | Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004) |
| "The purpose of this study is to evaluate women receiving methadone maintenance during pregnancy." | 3.70 | Methadone maintenance in pregnancy: a reappraisal. ( Britton, KA; Brizendine, E; Brown, HL; Hiett, AK; Mahaffey, D; Turnquest, MA, 1998) |
| " Women who reduced their methadone dose during pregnancy delivered babies of significantly higher birth weight than those whose methadone dose remained the same or increased (median 3027 g, range 1780-3629 g vs 2645 g, range 580-3720 g)." | 3.70 | Outcome predictors in pregnant opiate and polydrug users. ( McCarthy, JE; Ruben, SM; Shaw, NJ; Siney, C, 1999) |
| " The majority of women in the CDU clinic were treated for narcotic addiction with methadone (90%) but most continued to use heroin during pregnancy (68%)." | 3.70 | The drug epidemic: effects on newborn infants and health resource consumption at a tertiary perinatal centre. ( Davis, PG; Henschke, PN; Kelly, JJ, 2000) |
| " The drug-dependent women had used combinations of methadone, heroin, cocaine and other drugs during pregnancy." | 3.69 | Development after prenatal exposure to cocaine, heroin and methadone. ( Akkerhuis, GW; Gunning, WB; Soepatmi, S; van Baar, AL, 1994) |
| "A prospective longitudinal study on the development of children of drug-dependent mothers who used combinations of cocaine, heroin and methadone during pregnancy was carried out in Amsterdam." | 3.69 | Cognitive development at preschool-age of infants of drug-dependent mothers. ( de Graaff, BM; van Baar, A, 1994) |
| " Persistent weight retardation at 12 months was correlated with methadone dosage during pregnancy, but not the need for phenobarbitone therapy." | 3.69 | Infants born to narcotic dependent mothers: physical growth patterns in the first 12 months of life. ( Chant, DC; Gray, PH; Hayes, AJ; Tudehope, DI; Vance, JC, 1997) |
| "This spectrum of relationships supports the concept that careful reduction of the maternal methadone dosage during pregnancy under intensive medical and psychosocial surveillance may benefit the drug-exposed new-born infant clinically." | 3.68 | Relationship between maternal methadone dosage, maternal-neonatal methadone levels, and neonatal withdrawal. ( Doberczak, TM; Friedmann, P; Kandall, SR, 1993) |
| " Both of the mothers were on methadone maintenance for narcotic dependency prior to the diagnosis of pregnancy." | 3.68 | Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate. ( Hinderliter, SA; Sutton, LR, 1990) |
| "This paper describes patterns of drug use such as choice of drug, other substances abused, and route of administration in 174 women who reported methamphetamine, cocaine, heroin, or "Ts and blues" abuse during pregnancy." | 3.68 | Patterns of multiple substance abuse during pregnancy: implications for mother and fetus. ( Gilstrap, LD; Johnston, WL; Little, BB; Snell, LM, 1990) |
| " Apnea density and episodes of periodic breathing exceeded the 95th percentile for normal infants in 12 (38%) of 32 of cocaine-exposed infants vs only 1 (6%) of 18 opiate-exposed infants." | 3.67 | Prenatal cocaine exposure is associated with respiratory pattern abnormalities. ( Chasnoff, IJ; Hunt, CE; Kaplan, D; Kletter, R, 1989) |
| "To determine the effects of human immunodeficiency virus (HIV) infection on pregnancy outcomes, we prospectively studied female intravenous drug users in a methadone program in New York City." | 3.67 | Prospective study of human immunodeficiency virus infection and pregnancy outcomes in intravenous drug users. ( Davenny, K; Feingold, AR; Friedland, GH; Klein, RS; Mayers, MM; Robertson, VJ; Rogers, MF; Schoenbaum, EE; Selwyn, PA; Shulman, JF, 1989) |
| "The authors describe their experience with methadone treatment in pregnancy." | 3.67 | Methadone in pregnancy: clinical-toxicological aspects. ( Chiarotti, M; De Giovanni, N; Falasconi, AM; Offidani, C, 1986) |
| "We studied the influence of human pregnancy on the maternal disposition and effects of methadone." | 3.67 | Altered methadone pharmacokinetics in methadone-maintained pregnant women. ( Benowitz, NL; Kreek, MJ; Pond, SM; Raghunath, J; Tong, TG, 1985) |
| " These two groups were compared with a group of women who had used narcotics in the past and were maintained on methadone during pregnancy, and with a group of drug-free women." | 3.67 | Cocaine use in pregnancy. ( Burns, KA; Burns, WJ; Chasnoff, IJ; Schnoll, SH, 1985) |
| "This article explores the issues raised by methadone maintenance during pregnancy with a focus on intervention techniques for the drug counselor." | 3.67 | When the client is pregnant: information for counselors. ( Williams, A, 1985) |
| "This study compares the first year's health, neurodevelopmental status, and environment of infants of drug-dependent mothers attending methadone programs during pregnancy with those of drug-dependent mothers not enrolled in treatment programs (untreated)." | 3.66 | Follow-up of methadone-treated and untreated narcotic-dependent women and their infants: health, developmental, and social implications. ( Desmond, MM; Wait, RB; Wilson, GS, 1981) |
| "Minute ventilation, end-tidal PCO2, O2 and CO2 concentrations in expired air, pulse rate and arterial blood pressure were measured in the last half of pregnancy in eight women taking methadone daily." | 3.66 | Respiratory and hemodynamic effects of methadone in pregnant women. ( Dunham, MJ; Krall, MA; Metcalfe, J; Olsen, GD, 1980) |
| " Heroin abuse declined while methadone usage increased during those years." | 3.65 | The narcotic-dependent mother: fetal and neonatal consequences. ( Albin, S; Eidelman, A; Gartner, LM; Kandall, SR; Lee, KS; Lowinson, J, 1977) |
| "The course of pregnancy and delivery in 28 women under closely supervised methadone maintenance (group 1) was compared with that of 57 women using heroin or methadone under less controlled circumstances (group 2) and with that of 30 women free of mood-altering medications (group 3)." | 3.65 | Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs. ( Adamsons, K; Stimmel, B, 1976) |
| " Mean birthweight of infants born to mothers abusing heroin during the pregnancy was 2,490 gm, an effect primarily of intrauterine growth retardation." | 3.65 | Differential effects of maternal heroin and methadone use on birthweight. ( Albin, S; Berle, B; Eidelman, AI; Gartner, LM; Kandall, SR; Lowinson, J, 1976) |
| "A pregnant patient in the midtrimester of pregnancy was begun on a methadone detoxification program." | 3.65 | Fetal stress from methadone withdrawal. ( Davis, R; Gumpel, JA; Madden, J; Mejia-Zelaya, A; Zuspan, FP, 1975) |
| " Morphine was detected in significant amounts in maternal and fetal urine regardless of whether the mother was on a methadone program or whether she denied any use of heroin during the last trimester of pregnancy." | 3.65 | A study of factors that influence the severity of neonatal narcotic withdrawal. ( Chavez, CJ; Ostrea, EM; Strauss, ME, 1975) |
| "Drug addiction during pregnancy has been managed in two ways: the detoxification program and the methadone-maintenance treatment program." | 3.65 | Drug addiction in pregnancy and the neonate. ( Ackerman, BD; Blinick, G; Jerez, E; Wallach, RC, 1976) |
| "Methadone maintenance treatment (MMT) is the gold standard for pregnant women with opioid use disorders." | 2.84 | Newborn birth-weight of pregnant women on methadone or buprenorphine maintenance treatment: A national contingency management approach trial. ( Adelson, M; Peles, E; Sason, A; Schreiber, S, 2017) |
| "Smoking during pregnancy is the leading preventable cause of poor pregnancy outcomes in the United States." | 2.78 | Illicit drug use among pregnant women enrolled in treatment for cigarette smoking cessation. ( Bernstein, IM; Gaalema, DE; Heil, SH; Higgins, ST; Pepin, CS, 2013) |
| "Lessons learned in research and treatment of opioid dependence demonstrate the need to include pregnant women in clinical trials." | 2.78 | Lessons learned from a comparison of evidence-based research in pregnant opioid-dependent women. ( Baewert, A; Fischer, G; Graf-Rohrmeister, K; Jagsch, R; Langer, M; Thau, K; Unger, A; Winklbaur-Hausknost, B, 2013) |
| "How best to measure the occurrence of adverse events during a randomized clinical trial is an issue that has not been adequately examined in the research literature." | 2.77 | Nonserious adverse events in randomized trials with opioid-dependent pregnant women: direct versus indirect measurement. ( Arria, AM; Coyle, MG; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Selby, P; Stine, SM, 2012) |
| "Buprenorphine compared with methadone appears to result in less suppression of mean fetal heart rate, fetal heart rate reactivity and the biophysical profile score after medication dosing and these findings provide support for the relative safety of buprenorphine when fetal indices are considered as part of the complete risk-benefit ratio." | 2.77 | Fetal assessment before and after dosing with buprenorphine or methadone. ( Coyle, MG; Heil, SH; Jones, HE; Kaltenbach, K; Martin, PR; O'Grady, KE; Salisbury, AL; Stine, SM; Weninger, M, 2012) |
| " Pregnant women (and parents with children) were forced to negotiate dosing in dangerous conditions." | 2.72 | Changing Outdated Methadone Regulations That Harm Pregnant Patients. ( Jones, HE; McCarthy, JJ; Rudolf, VP; Terplan, M; von Klimo, MC, 2021) |
| "Intensive treatment for nicotine dependence, environmental interventions, and innovative harm reduction strategies are recommended to address the barriers to quitting observed in this population of pregnant women." | 2.71 | Motivational enhancement therapy for nicotine dependence in methadone-maintained pregnant women. ( Diclemente, C; Haug, NA; Svikis, DS, 2004) |
| "Perinatal prognosis of pregnant drug abusers is better with intensive prenatal care and substitution maintenance programs." | 2.70 | [Withdrawal syndromes of newborns of pregnant drug abusers maintained under methadone or high-dose buprenorphine: 246 cases]. ( Aubisson, S; Cneude, F; Gourarier, L; Lejeune, C; Piquet, M; Simmat-Durand, L, 2001) |
| "A retrospective, inception cohort, nonrandomized control design was employed to evaluate the effects of daily vs twice daily dosing of methadone on opiate/cocaine use, and noncompliance with urine toxicology requests in methadone-maintained pregnant women, n = 45." | 2.68 | Methadone dosing and pregnancy: impact on program compliance. ( DePetrillo, PB; Rice, JM, 1995) |
| "Opioid use during pregnancy has serious consequences for mother and baby." | 2.66 | Management and monitoring of opioid use in pregnancy. ( Ibsen, IO; Jørgensen, JS; Lamont, RF; Rausgaard, NLK; Ravn, P, 2020) |
| "Treatment with buprenorphine or methadone is associated with NOWS, but neither medication appears to have significant adverse effects on early childhood development." | 2.61 | Opioid Use in Pregnancy. ( Forray, A; Habecker, E; Tobon, AL, 2019) |
| "Women with opioid use disorder who become pregnant are a particularly vulnerable population and require a comprehensive treatment approach for mother and fetus." | 2.61 | Opioid use disorder during pregnancy: An overview. ( Carter, LC; Nicholas, JS; Read, L; Read, MA; Schmidt, E, 2019) |
| "Methadone is a long-acting mu-opioid receptor agonist that has been shown to increase retention in treatment programs and attendance at prenatal care while decreasing pregnancy complications." | 2.61 | Pharmacological treatment of opioid use disorder in pregnancy. ( Klie, KA; Rodriguez, CE, 2019) |
| "When opioid misuse rises in the United States, pregnant women and their neonates are affected." | 2.61 | Analgesia, Opioids, and Other Drug Use During Pregnancy and Neonatal Abstinence Syndrome. ( Jones, HE; Kraft, WK, 2019) |
| "Options for treatment of opioid dependence, acute pain management, and perioperative multimodal analgesia are discussed." | 2.55 | Peripartum Anesthetic Management of the Opioid-tolerant or Buprenorphine/Suboxone-dependent Patient. ( Pan, A; Zakowski, M, 2017) |
| "Pregnant women with opioid use disorder can be treated with methadone, buprenorphine, or naltrexone to reduce opioid use and improve retention to treatment." | 2.55 | Methadone, Buprenorphine, and Naltrexone for the Treatment of Opioid Use Disorder in Pregnant Women. ( Griffin, BL; Stone, RH; Todd, TJ; Tran, TH; Vest, KM, 2017) |
| " Recommendations are made for further research into physician/patient interactions and into optimal dosing of methadone and buprenorphine to minimize maternal/fetal withdrawal." | 2.55 | Opioid dependence and pregnancy: minimizing stress on the fetal brain. ( Fassbender, C; Finnegan, LP; Leamon, MH; McCarthy, JJ, 2017) |
| "Methadone has been the mainstay of maintenance treatment for nearly 50 years, but recent research has found that both methadone and buprenorphine maintenance treatments significantly improve maternal, fetal and neonatal outcomes." | 2.52 | Pharmacological Management of Opioid Use Disorder in Pregnant Women. ( Wilder, CM; Winhusen, T, 2015) |
| "Methadone maintenance treatment (MMT) helps individuals with an opioid use disorder abstain from or decrease use of illegal or nonmedical opiates." | 2.50 | Medication-assisted treatment with methadone: assessing the evidence. ( Daniels, AS; Delphin-Rittmon, ME; Dougherty, RH; Fullerton, CA; Ghose, SS; Kim, M; Lyman, DR; Montejano, LB; Thomas, CP, 2014) |
| "Buprenorphine is a newer treatment for maternal opioid addiction and appears to result in a milder withdrawal syndrome than methadone." | 2.50 | Neonatal opioid withdrawal syndrome. ( Hsi, A; Leeman, L; Sutter, MB, 2014) |
| "Managing opioid dependence in pregnant women is a complex and potentially challenging task." | 2.49 | Managing opioid dependence in pregnancy -- a general practice perspective. ( Arunogiri, S; Foo, L; Frei, M; Lubman, DI, 2013) |
| "Birth weight was higher in the buprenorphine group in the two trials that could be pooled (mean difference (MD) -365." | 2.49 | Maintenance agonist treatments for opiate-dependent pregnant women. ( Amato, L; Bellisario, C; Davoli, M; Ferri, M; Minozzi, S, 2013) |
| "Neonatal abstinence syndrome has become a growing concern in infants born to substance-abusing mothers in the State of Florida." | 2.49 | Pharmacologic management of neonatal abstinence syndrome in a community hospital. ( Calhoun, DA; Napolitano, A; Seng, SK; Theophilopoulos, D, 2013) |
| "Methadone maintenance treatment has definite advantages for the mother and is currently recommended in the UK." | 2.47 | The management of heroin misuse in pregnancy: time for a rethink? ( Mactier, H, 2011) |
| " With respect to the particular consumed drug substances other than opioids during pregnancy variable forms of teratogenic and toxic effects can be assigned to the baby." | 2.47 | [Pregnant opioid addicted patients and additional drug intake. Part I. Toxic effects and therapeutic consequences]. ( Havemann-Reinecke, U; Hoell, I, 2011) |
| "Women using methadone for treatment of opioid dependence should not be discouraged from breastfeeding." | 2.44 | Methadone exposure during lactation. ( Finkelstein, Y; Garcia-Bournissen, F; Glatstein, MM; Koren, G, 2008) |
| " These recommendations address: antepartum issues including treatment, dosage and pharmacological considerations, medical conditions and lab tests, intrapartum issues, postpartum concerns including breastfeeding, neonatal withdrawal, and developmental effects associated with methadone." | 2.41 | Clinical management of methadone dependence during pregnancy. ( Curet, LB; Dorato, V; Wallerstedt, C; Wilbourne, P, 2001) |
| "Methadone maintenance for the treatment of opioid dependence is described in this article." | 2.40 | Opioid dependence during pregnancy. Effects and management. ( Berghella, V; Finnegan, L; Kaltenbach, K, 1998) |
| "With methadone treatment, there is a decline in the amount of heroin used and in the number of injections." | 2.40 | [Substitution therapy of drug addicts]. ( Kopferschmitt, J; Weber, JC, 1998) |
| "Methadone maintenance is an important component of the management of many pregnant opioid addicts." | 2.38 | Narcotic use in pregnancy. ( Hoegerman, G; Schnoll, S, 1991) |
| "Characterize severity of opioid use disorder during pregnancy over time." | 1.72 | Trends in the severity of opioid use disorder during pregnancy over time. ( Bailit, JL; Sadananda, GB; Sundaresh, S, 2022) |
| "To determine the prevalence of substance abuse among our pregnant women and the characteristics of their pregnancies, deliveries and new-born infants." | 1.62 | Drug abuse during pregnancy and its neonatal impact. Analysis of the periods 2002-2008 and 2009-2017. ( Guarddon Pueyo, C; López-Vílchez, MÁ; Maya-Enero, S; Mur-Sierra, A, 2021) |
| "Methadone is an opioid drug commonly prescribed for treating opioid use disorder in pregnant women and was found to accumulate at high levels in the fetal brain of mice, which fell quickly after birth." | 1.62 | Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry. ( Allen, MR; Atwood, BK; Baucum, AJ; Engleman, EA; Gao, Y; Grecco, GG; Haggerty, DL; Hoffman, H; Huang, JY; Katner, SN; Kim, J; Lu, HC; Masters, AR; Metzger, CE; Mork, BE; Morris, CW; Newell, EA; Reeves, KC; Sheets, PL; Wu, YC; Yamamoto, BK, 2021) |
| "Women with histories of opioid misuse face drug-related stigma, which can be amplified during pregnancy." | 1.62 | Conceptualizing stigma in contexts of pregnancy and opioid misuse: A qualitative study with women and healthcare providers in Ohio. ( Clapp, J; Howard, H; Madden, D; Spadola, C; Syvertsen, JL; Toneff, H, 2021) |
| " High maternal dosing of buprenorphine is associated with lower BW and HC Z-scores but dose effect is not seen with methadone." | 1.62 | Impact of opioid maintenance treatment during pregnancy on neonatal birth weight and head circumference. ( Adekola, H; Bruder, A; Kumar, N; Masten, M; Monga, R; Moustafa, ASZ; Parmar, K; Rocha, FG; Sampath, V, 2021) |
| "Individuals receiving medications for opioid use disorder after delivery were included in the study." | 1.62 | Methadone and buprenorphine discontinuation among postpartum women with opioid use disorder. ( Bernson, D; Bernstein, J; Bharel, M; Greenfield, SF; Hadland, SE; Hoeppner, BB; Kelly, JF; Nielsen, TC; Reddy, J; Schiff, DM; Taveras, EM; Terplan, M; Wilens, TE, 2021) |
| "Longer duration of medication for opioid use disorder use during pregnancy appears to be associated with improved maternal and perinatal outcomes." | 1.62 | Outcomes associated with the use of medications for opioid use disorder during pregnancy. ( Chen, Q; James, AE; Jarlenski, MP; Kelley, D; Kim, JY; Krans, EE; Rothenberger, SD, 2021) |
| "The methadone group had a lower mean newborn birthweight (2874±459 g) and a greater incidence of low birth weight (11." | 1.56 | Comparison of buprenorphine and methadone in the management of maternal opioid use disorder in full term pregnancies. ( Davis, JA; Garretto, D; Garry, ET; Herrera, KM; Ly, V; Staszewski, CL, 2020) |
| " In all analyses, methadone and buprenorphine dosing were evaluated as a continuous variable." | 1.56 | Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome. ( Bailit, JL; Gibson, KS; Lappen, JR; Stark, S, 2020) |
| "Opioid use during pregnancy is rising, with an estimated 14-22% of women obtaining an opioid prescription during pregnancy." | 1.56 | Factors associated with treatment retention in pregnant women with opioid use disorders prescribed methadone or electing non-pharmacological treatment. ( Haug, NA; Jancaitis, B; Kelpin, S; Masho, S; May, J; Svikis, D, 2020) |
| "Perinatal opioid use disorder (OUD) is a life-threatening condition that significantly impacts women in rural areas." | 1.51 | Treating perinatal opioid use disorder in rural settings: Challenges and opportunities. ( Goodman, DJ; Higgins, TM; Meyer, MC, 2019) |
| "Opioid addiction in pregnancy is a growing concern that has recently received a great deal of attention." | 1.48 | Invited Commentary: A Novel Strategy for Addressing Unmeasured Confounding When Comparing Opioid Agonist Therapies in Pregnancy. ( Lemon, LS, 2018) |
| "Buprenorphine or methadone was initiated clinically." | 1.48 | Prenatal Treatment and Outcomes of Women With Opioid Use Disorder. ( Brogly, SB; Hernández-Díaz, S; Regan, E; Saia, KE; Werler, MM, 2018) |
| "Methadone was most frequently used for prenatal opioid dependence; there was little buprenorphine or buprenorphine + naloxone use." | 1.46 | Infants Born to Opioid-Dependent Women in Ontario, 2002-2014. ( Brogly, SB; Davies, G; Dow, K; Johnson, A; Lajkosz, K; Newman, A; Turner, S, 2017) |
| "Pregnancy is an opportune time to identify opioid dependence, facilitate conversion to opioid maintenance treatment, and coordinate care with specialists in addiction medicine, behavioral health, and social services." | 1.42 | Caring for Opioid-dependent Pregnant Women: Prenatal and Postpartum Care Considerations. ( Bogen, DL; Cochran, G; Krans, EE, 2015) |
| "Opioid addiction is no longer a primarily urban problem." | 1.42 | Caring for pregnant opioid abusers in Vermont: A potential model for non-urban areas. ( Meyer, M; Phillips, J, 2015) |
| "The historical and current contexts of opioid use disorders during pregnancy are reviewed." | 1.39 | Treating opioid use disorders during pregnancy: historical, current, and future directions. ( Jones, HE, 2013) |
| "Pregnant women meeting criteria for opioid dependence and attending an integrated care program between 1997 and 2009." | 1.39 | Integrated care for pregnant women on methadone maintenance treatment: Canadian primary care cohort study. ( Abrahams, R; Boyajian, T; Graves, L; Kahan, M; Ordean, A, 2013) |
| "Weight loss was less in small for gestational age compared to appropriately grown infants (p<0." | 1.38 | Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding. ( Campbell, N; Dryden, C; Mactier, H; Young, D, 2012) |
| "Methadone maintenance treatment (MMT) is the standard treatment of choice for pregnant opiate addicts; however, data on newborn outcomes are contradictory." | 1.38 | Duration of methadone maintenance treatment during pregnancy and pregnancy outcome parameters in women with opiate addiction. ( Adelson, M; Bloch, M; Dollberg, S; Peles, E; Schreiber, S, 2012) |
| "The cohort of women treated for opioid dependence during pregnancy with medication-assisted therapy and delivered at a single institution between 2000 and 2006 were retrospectively identified (n = 149 women; n = 151 neonates)." | 1.38 | Development of a substance abuse program for opioid-dependent nonurban pregnant women improves outcome. ( Benvenuto, A; Howard, D; Johnston, A; Mandell, T; Metayer, J; Meyer, M; Plante, D, 2012) |
| "Neonatal abstinence syndrome is an expected and treatable condition that follows prenatal exposure to opioid agonists." | 1.38 | ACOG Committee Opinion No. 524: Opioid abuse, dependence, and addiction in pregnancy. ( , 2012) |
| "Pregnancy care for these women needs to continue to develop to improve overall outcomes." | 1.38 | Maternal and neonatal outcomes following methadone substitution during pregnancy. ( Ash, A; Douiri, A; Greig, E, 2012) |
| "Buprenorphine as maintenance treatment of opioid dependence during pregnancy has promise and may offer some benefits, but more research is needed, especially regarding induction of actively addicted women during pregnancy." | 1.38 | Treatment of opioid dependence in the setting of pregnancy. ( Martin, PR; Young, JL, 2012) |
| "Patterns of symptom reports may have clinical implications for maternal and fetal health during pregnancy for OM women including optimization of opioid dosing regimens, education regarding maternal nutritional intake and preventing postnatal depression, thereby ensuring maternal health and fetal development during pregnancy and enhancing mother-infant bonding and healthy child development postnatally." | 1.38 | Patterns of symptom reporting during pregnancy comparing opioid maintained and control women. ( Fisk, A; Gordon, AL; Lopatko, OV; Pearson, V; Stacey, H; White, JM; Woods, A, 2012) |
| "Methadone treatment is a well-recognised cause of QT interval lengthening in adults." | 1.37 | Maternal methadone therapy increases QTc interval in newborn infants. ( Bhoyar, A; Ewer, AK; Holder, G; Hussain, T; Parikh, R, 2011) |
| " Maternal opiate dosing has been investigated with conflicting results." | 1.36 | Perinatal risk factors for the neonatal abstinence syndrome in infants born to women on methadone maintenance therapy. ( Cook, CM; Jones, MP; Liu, AJ; Murray, H; Nanan, R, 2010) |
| "Five methadone clients were interviewed at the clinic and interviews taped for transcription with consent." | 1.36 | A special type of 'hard-to-reach' patient: experiences of pregnant women on methadone. ( Calvin, C; Moriarty, H, 2010) |
| "They were also offered residential treatment before pregnancy and after the child was born." | 1.35 | Patterns in sleep-wakefulness in three-month old infants exposed to methadone or buprenorphine. ( Bakstad, B; Martinsen, H; Røislien, J; Sarfi, M; Waal, H, 2009) |
| "Treatment of maternal opioid dependence with methadone is associated with a delay in fetal heart rate (FHR) accelerations in nonstress tests." | 1.33 | Effect of chronic maternal methadone therapy on intrapartum fetal heart rate patterns. ( Flores, S; McKay, J; Ramirez-Cacho, WA; Rayburn, WF; Schrader, RM, 2006) |
| "Urine samples were analyzed for drug abuse after one month and after one year." | 1.33 | Gender differences and pregnant women in a methadone maintenance treatment (MMT) clinic. ( Adelson, M; Peles, E, 2006) |
| "The purpose of this study was to determine whether maternal methadone dosage correlates with neonatal withdrawal in a large heroin-addicted pregnant population." | 1.32 | Maternal methadone dose and neonatal withdrawal. ( Berghella, V; Chennat, J; Cherpes, J; Hill, MK; Kaltenbach, K; Lim, PJ, 2003) |
| "Methadone levels were kept blinded from clinicians." | 1.31 | Methadone trough levels in pregnancy. ( Berghella, V; Drozdick, J; Hill, M; Kaltenbach, K, 2002) |
| "Women with mild withdrawal symptoms were given clonidine initially, and methadone was substituted if symptoms persisted." | 1.30 | Opioid detoxification in pregnancy. ( Dashe, JS; Jackson, GL; Olscher, DA; Wendel, GD; Zane, EH, 1998) |
| "Traditionally, methadone maintenance therapy has been a once-daily dosing schedule." | 1.30 | Alterations in methadone metabolism during late pregnancy. ( Jarvis, MA; Kniseley, JS; Schnoll, SH; Wu-Pong, S, 1999) |
| " The reactivity of the nonstress tests, biophysical profile scores and time needed to complete the biophysical profiled before and after methadone dosing were compared." | 1.29 | Effect of methadone on the biophysical profile. ( Cejtin, HE; Mills, A; Swift, EL, 1996) |
| " Methadone plasma concentration-time data were fit to a one-compartment pharmacokinetic model by extended least-squares regression." | 1.28 | Altered methadone pharmacokinetics in pregnancy: implications for dosing. ( Camara, P; DePetrillo, P; Dudley, M; Griffiths, W; Swift, RM, 1989) |
| "Methadone was only one among the risk factors affecting interaction." | 1.27 | A longitudinal study of offspring born to methadone-maintained women. II. Dyadic interaction and infant behavior at 4 months. ( Bernstein, V; Hans, SL; Jeremy, RJ; Marcus, J, 1984) |
| "85% of the newborns had withdrawal symptoms and 12% had convulsions the severity of which was not correlated with the type of drug abuse." | 1.27 | Investigation of 89 children born by drug-dependent mothers. I. Neonatal course. ( Andersen, GE; Buckley, W; Friis-Hansen, B; Olofsson, M, 1983) |
| "There are multiple causes for intrauterine growth retardation but one etiology proposed is maternal drugs." | 1.27 | Maternal drug therapy: effect on fetal and neonatal growth and neurobehavior. ( Hill, RM; Tennyson, LM, 1986) |
| "The increased rate of prematurity, intrauterine growth retardation, and perinatal complications associated with perinatal exposure to cocaine or methamphetamine was greater than that predicted by coexisting risk factors and was consistent with the pharmacologic properties of these drugs." | 1.27 | Perinatal cocaine and methamphetamine exposure: maternal and neonatal correlates. ( Dixon, SD; Oro, AS, 1987) |
| " These data suggest that maternal drug abuse and increased methadone dosage during pregnancy may predispose infants to the development of strabismus." | 1.27 | Occurrence of strabismus in infants born to drug-dependent women. ( Calhoun, JH; Ehrlich, S; Finnegan, LP; Matteucci, T; Nelson, LB, 1987) |
| "This incidence of SIDS was 5." | 1.26 | Sudden unexpected death in infants of narcotic-dependent mothers. ( Falciglia, H; Kandall, SR; Rajegowda, BK, 1978) |
| " In the mothers, no significant differences were found with respect to dosage and duration of methadone treatment and years of heroin abuse." | 1.26 | Cytogenetics of methadone-managed and heroin-addicted pregnant women and their newborn infants. ( Amarose, AP; Norusis, MJ, 1976) |
| "Neonatal withdrawal symptoms appear to be related to individual variation in maternal metabolism of the drug, placental transfer of methadone, and most importantly, to the individual variations in the rate of excretion of methadone as reflected in the neonatal plasma t 1/2." | 1.26 | Pharmacologic observations on the neonatal withdrawal syndrome. ( Pippenger, CE; Rosen, TS, 1976) |
| " No significant association was found between maternal dosage of methadone in the last trimester of pregnancy and lentth of gestation, birth weight, or the reported presence of withdrawal symptoms in the neonate." | 1.25 | Results of 313 consecutive live births of infants delivered to patients in the New York City Methadone Maintenance Treatment Program. ( Bashkow, S; Calko, D; Newman, RG, 1975) |
| "Several cases of chronic unsuspected infections in addicts' infants are reported, raising the question of the significance of undiagnosed infection as it affects growth." | 1.25 | Somatic growth effects of perinatal addiction. ( Wilson, GS, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 142 (29.16) | 18.7374 |
| 1990's | 49 (10.06) | 18.2507 |
| 2000's | 73 (14.99) | 29.6817 |
| 2010's | 182 (37.37) | 24.3611 |
| 2020's | 41 (8.42) | 2.80 |
| Authors | Studies |
|---|---|
| Piske, M | 1 |
| Homayra, F | 1 |
| Min, JE | 1 |
| Zhou, H | 1 |
| Marchand, C | 1 |
| Mead, A | 1 |
| Ng, J | 1 |
| Woolner, M | 1 |
| Nosyk, B | 1 |
| Sujan, A | 1 |
| Cleary, E | 1 |
| Douglas, E | 1 |
| Aujla, R | 1 |
| Boyars, L | 2 |
| Smith, C | 1 |
| Guille, C | 3 |
| Staszewski, C | 1 |
| Herrera, KM | 2 |
| Kertowidjojo, E | 1 |
| Ly, V | 2 |
| Iovino, N | 1 |
| Garretto, D | 2 |
| Kaplan, C | 1 |
| Persad, MD | 1 |
| Garry, DJ | 1 |
| Sundaresh, S | 1 |
| Sadananda, GB | 1 |
| Bailit, JL | 3 |
| Nguemeni Tiako, MJ | 2 |
| Meinhofer, A | 1 |
| Friedman, A | 1 |
| South, EC | 1 |
| Epstein, RL | 1 |
| Meisel, ZF | 2 |
| Morgan, JR | 1 |
| Suarez, EA | 3 |
| Huybrechts, KF | 4 |
| Straub, L | 3 |
| Hernández-Díaz, S | 7 |
| Jones, HE | 39 |
| Connery, HS | 3 |
| Davis, JM | 4 |
| Gray, KJ | 3 |
| Lester, B | 3 |
| Terplan, M | 12 |
| Mogun, H | 4 |
| Bateman, BT | 4 |
| Kanervo, MM | 1 |
| Tupola, SJ | 1 |
| Nikkola, EM | 1 |
| Rantakari, KM | 1 |
| Kahila, HK | 1 |
| Wang, S | 1 |
| Meador, KJ | 1 |
| Pawasauskas, J | 1 |
| Lewkowitz, AK | 1 |
| Ward, KE | 1 |
| Brothers, TN | 1 |
| Hartzema, A | 2 |
| Quilliam, BJ | 1 |
| Wen, X | 1 |
| Vella, A | 1 |
| Savona-Ventura, C | 1 |
| Mahmood, T | 1 |
| Kelty, E | 3 |
| Havard, A | 1 |
| Preen, DB | 1 |
| Handal, M | 3 |
| Nechanská, B | 3 |
| Skurtveit, S | 3 |
| Lund, IO | 2 |
| Gabrhelík, R | 3 |
| Engeland, A | 2 |
| Mravčík, V | 3 |
| Kroska, EB | 1 |
| Meller, EW | 1 |
| Doyle, R | 1 |
| Coker, JL | 2 |
| Knight, BT | 1 |
| Ray-Griffith, SL | 1 |
| Nembhard, WN | 1 |
| Stowe, ZN | 2 |
| Premkumar, A | 1 |
| Grobman, WA | 1 |
| Miller, ES | 2 |
| MacMillan, KDL | 1 |
| Tobon, AL | 1 |
| Habecker, E | 1 |
| Forray, A | 1 |
| Nelson, LF | 1 |
| Yocum, VK | 1 |
| Patel, KD | 1 |
| Qeadan, F | 1 |
| Hsi, A | 3 |
| Weitzen, S | 1 |
| Andrews, L | 1 |
| Davies, TH | 1 |
| Haas, J | 1 |
| Loudin, S | 1 |
| Heyward, A | 1 |
| Werthammer, J | 1 |
| Kranzler, HR | 1 |
| Washio, Y | 1 |
| Zindel, LR | 1 |
| Lynch, KG | 1 |
| Hand, D | 1 |
| Tyndale, RF | 1 |
| Oncken, C | 1 |
| Schnoll, R | 1 |
| Schiff, DM | 3 |
| Nielsen, T | 2 |
| Hoeppner, BB | 2 |
| Hansen, H | 1 |
| Bernson, D | 3 |
| Diop, H | 2 |
| Bharel, M | 3 |
| Krans, EE | 5 |
| Selk, S | 1 |
| Kelly, JF | 2 |
| Wilens, TE | 3 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective Randomized Blinded Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS)[NCT04455802] | Phase 3 | 0 participants (Actual) | Interventional | 2020-10-01 | Withdrawn (stopped due to termination of funding) | ||
| Comparison of Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal Symptomatology[NCT03740243] | Phase 4 | 0 participants (Actual) | Interventional | 2018-11-30 | Withdrawn (stopped due to No enrollment) | ||
| Maternal Opioid Treatment: Human Experimental Research[NCT00271219] | Phase 3 | 175 participants (Actual) | Interventional | 2005-07-31 | Completed | ||
| A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407] | 55 participants (Actual) | Interventional | 2017-04-20 | Completed | |||
| MOms in REcovery (MORE): Defining Optimal Care for Pregnant Women and Infants[NCT04251208] | 444 participants (Actual) | Observational | 2019-07-30 | Active, not recruiting | |||
| Improving Alcohol and Substance Use Care Access, Outcomes, and Equity During the Reproductive Years: A Type 1 Hybrid Trial in Family Planning Clinics[NCT05910580] | 600 participants (Anticipated) | Interventional | 2024-04-01 | Not yet recruiting | |||
| PRevention Of Methamphetamine Use Among Postpartum Women Trial (PROMPT)[NCT05128071] | Early Phase 1 | 40 participants (Anticipated) | Interventional | 2022-02-04 | Recruiting | ||
| Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome[NCT02851303] | Phase 4 | 61 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Improving Outcomes in Neonatal Abstinence Syndrome[NCT01958476] | Phase 3 | 117 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| Treating the Partners of Drug Using Pregnant Women: Stage II[NCT00496990] | Phase 2/Phase 3 | 158 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| Fetal Neurobehavior in Non-methadone Maintained Women in Substance Abuse Treatment[NCT00522626] | 19 participants (Actual) | Observational | 2006-08-31 | Completed | |||
| Methadone, Buprenorphine and Fetal Neurobehavior[NCT00653692] | 29 participants (Actual) | Observational | 2007-05-31 | Completed | |||
| Safety, Efficacy, Pharmacokinetics, and Pharmacogenomics of Extended-Release Naltrexone in Pregnant Women[NCT03718104] | 100 participants (Anticipated) | Observational | 2018-12-01 | Recruiting | |||
| The Effects of Opioid Taper on Opioid-Induced Hyperalgesia[NCT03063905] | 15 participants (Actual) | Observational | 2017-01-31 | Terminated (stopped due to funding expired) | |||
| Effect of Continuous Positive Airway Pressure on Fetal pH at Time of Scheduled Cesarean Delivery in Morbidly Obese Women[NCT04993651] | 80 participants (Anticipated) | Interventional | 2021-10-11 | Recruiting | |||
| Methadone, Buprenorphine and Fetal Development[NCT00067184] | 157 participants (Actual) | Observational | 2002-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00271219)
Timeframe: birth
| Intervention | cm (Mean) |
|---|---|
| A Methadone | 33.0 |
| B Buprenorphine | 33.8 |
(NCT00271219)
Timeframe: delivery until hospital discharge (min=2 days, max=79 days)
| Intervention | days (Mean) |
|---|---|
| A Methadone | 17.5 |
| B Buprenorphine | 10.0 |
NAS was measured with the MOTHER NAS scale, which includes 28 items, 19 of which are used for scoring and medication decisions. Scores can range from 0 to 42, with higher scores indicating more severe withdrawal. (NCT00271219)
Timeframe: minimum twice daily from birth until NAS no longer measured (min=10 days)
| Intervention | Score on the scale (Mean) |
|---|---|
| A Methadone | 12.8 |
| B Buprenorphine | 11.0 |
(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | percentage of HIV risk behaviors (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
Pregnant women maintained on an opioid agonist medication may require upward adjustment to their medication during the course of pregnant. The Dose Adequacy Measure represented a recordation of dosing adjustments during the course of the study. (NCT00271219)
Timeframe: from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | dose increase per trimester (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
The Addiction Severity Index is a structured clinical interview that assesses problem severity in 7 areas of functioning: alcohol use, drug use, medical, legal, employment, psychosocial, and psychiatric status. Each area of functioning yields a composite scale score between 0 and 1, with higher scores indicating greater problem severity in that area. Only the psychosocial index was examined in this study. (NCT00271219)
Timeframe: at delivery
| Intervention | Score on the scale (Mean) |
|---|---|
| Methadone | .014 |
| Buprenorphine | .088 |
(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | percentage of drug use (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
Neonatal abstinence syndrome (NAS) characterized by hyperirritability of the central nervous system and dysfunction in the autonomic nervous system, gastrointestinal tract, and respiratory system.11 When left untreated, NAS can result in serious illness (e.g., diarrhea, feeding difficulties, weight loss, and seizures) and death. (NCT00271219)
Timeframe: From birth until hospital discharge (min=4 days, max=10, depending on site)
| Intervention | participants (Number) |
|---|---|
| A Methadone | 41 |
| B Buprenorphine | 27 |
Total amount in mg (NCT00271219)
Timeframe: Start of NAS treatment until discontinuation of NAS treatment (min=0 days, max=76 days)
| Intervention | mg (Mean) |
|---|---|
| A Methadone | 10.4 |
| B Buprenorphine | 1.1 |
Assessed through chart review of discharge summary documentation of method of infant feeding at time of discharge (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 5 |
| Methadone | 5 |
Number of days in hospital after birth (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | days (Mean) |
|---|---|
| Morphine | 17.9 |
| Methadone | 16.1 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | days (Mean) |
|---|---|
| Morphine | 14.7 |
| Methadone | 12.8 |
clonidine (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 1 |
| Methadone | 0 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 11 |
| Methadone | 6 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 0 |
| Methadone | 3 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | morphine equivalents mg (Mean) |
|---|---|
| Morphine | 9.86 |
| Methadone | 33.0 |
Average head circumference growth outcome at 18 month follow-up visit. (NCT01958476)
Timeframe: 18 month follow-up visit
| Intervention | cm (Mean) |
|---|---|
| Methadone | 47.8 |
| Neonatal Morphine Solution | 48.2 |
Average length (cm) at 18 month follow-up visit. (NCT01958476)
Timeframe: 18 month follow-up visit
| Intervention | cm (Mean) |
|---|---|
| Methadone | 82.1 |
| Neonatal Morphine Solution | 81.7 |
Growth outcome weight (lbs) depicted as difference in averaged weights from birth to 18 month follow-up visit. Standard deviations were averaged between birth and 18 mo time points. (NCT01958476)
Timeframe: Birth to 18 month follow-up visit
| Intervention | lbs (Mean) |
|---|---|
| Methadone | 19.1 |
| Neonatal Morphine Solution | 18.7 |
Participants were monitored for the duration of their hospitalization, an expected mean of 22 days. (NCT01958476)
Timeframe: Participants will be monitored during their entire hospitalization, expected mean 22 days.
| Intervention | days (Mean) |
|---|---|
| Methadone | 21.8 |
| Neonatal Morphine Solution | 23.2 |
Participants were monitored for the duration of their hospitalization attributable to NAS only. (NCT01958476)
Timeframe: Participants were monitored for the duration of their hospitalization, expected mean 22 days.
| Intervention | days (Mean) |
|---|---|
| Methadone | 18.9 |
| Neonatal Morphine Solution | 21.1 |
Total number of days infant treated with replacement opioids while admitted to the hospital. (NCT01958476)
Timeframe: Participants were monitored for the duration of their hospitalization.
| Intervention | days (Mean) |
|---|---|
| Methadone | 14.7 |
| Neonatal Morphine Solution | 16.6 |
"One Finnegan score ≥12, or two consecutive scores ≥8 affirms the requirement for pharmacological treatment or increasing treatment dosage. If the infant continued to have two consecutive Finnegan Scores ≥8 two times consecutively, or one ≥12, the dose was increased to the next level. (Level I: 0.3 mg/kg/day) (Level II: 0.5 mg/kg/day) (Level III: 0.7 mg/kg/day)~A higher Finnegan score indicates greater severity of NAS (min 0, max 50)." (NCT01958476)
Timeframe: Participants were monitored for the duration of their hospitalization, an average of 22 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Methadone | 22 |
| Neonatal Morphine Solution | 28 |
Number of infants treated with a second medication following protocol, phenobarbital. If the Finnegan Score remained elevated (still scored ≥8 two times consecutively, or still scored once ≥12) despite increasing to a predetermined maximal opioid dose (methadone or morphine), phenobarbital was administered (20-mg/kg loading dose followed by 4-5 mg/kg daily). (NCT01958476)
Timeframe: Participants were monitored for the duration of their hospitalization, an average of 22 days.
| Intervention | Participants (Count of Participants) |
|---|---|
| Methadone | 10 |
| Neonatal Morphine Solution | 17 |
The Bayley Scales of Infant and Toddler Development (BSID-III) assesses the development of infants and children (1-42 months) through a series of developmental play tasks, identifying children with developmental delay. Raw scores of completed items are summarized within three distinct scale scores (Cognitive Scale, Language Scale, Motor Scale). Scale scores are each converted to composite scores to determine the child's performance compared with scores of age-matched children of typical development (percentile rank). A higher composite score indicates more ideal developmental outcome (range 40-160). At 18 month follow-up visit, participants were assessed using the BSID-III for cognitive, language and motor scale composite score outcomes. (NCT01958476)
Timeframe: Assessment at 18 month follow-up visit
| Intervention | scores on a scale (Composite) (Mean) | ||
|---|---|---|---|
| Cognitive Composite | Language Composite | Motor Composite | |
| Methadone | 100.1 | 96.0 | 103.6 |
| Neonatal Morphine Solution | 98.1 | 94.2 | 99.1 |
Fetal heart rate in beats per minute (NCT00522626)
Timeframe: 60 minutes
| Intervention | beats per minute (Mean) |
|---|---|
| Trough Fetal Heart Rate | 142.34 |
81 reviews available for methadone and Complications, Pregnancy
| Article | Year |
|---|---|
Harmful effects of opioid use in pregnancy: A scientific review commissioned by the European Board and College of obstetrics and gynaecology (EBCOG).
Topics: Analgesics, Opioid; Buprenorphine; Female; Gynecology; Humans; Infant; Methadone; Obstetrics; Opiate | 2023 |
Neonatal Abstinence Syndrome: Review of Epidemiology, Care Models, and Current Understanding of Outcomes.
Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Hypnotics and Sedatives; Infant, | 2019 |
Opioid Use in Pregnancy.
Topics: Buprenorphine; Child Development; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Sy | 2019 |
Cognitive Outcomes of Young Children After Prenatal Exposure to Medications for Opioid Use Disorder: A Systematic Review and Meta-analysis.
Topics: Analgesics, Opioid; Buprenorphine; Child Development; Child, Preschool; Cognition; Cognitive Dysfunc | 2020 |
Opioid Management in Pregnancy and Postpartum.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cesarean Section; Female; Humans; Infant, Newborn; Labor, | 2020 |
Changing Outdated Methadone Regulations That Harm Pregnant Patients.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Health Policy; Humans; Methadone; Opia | 2021 |
Maintenance agonist treatments for opiate-dependent pregnant women.
Topics: Birth Weight; Buprenorphine; Delayed-Action Preparations; Female; Humans; Infant; Infant, Newborn; M | 2020 |
Use of Medications for Treatment of Opioid Use Disorder Among US Medicaid Enrollees in 11 States, 2014-2018.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Child; Cross-Sectional Studies; Female; Humans | 2021 |
Peripartum Anesthetic Management of the Opioid-tolerant or Buprenorphine/Suboxone-dependent Patient.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Methado | 2017 |
A Retrospective Cohort Study of Obstetric Outcomes in Opioid-Dependent Women Treated with Implant Naltrexone, Oral Methadone or Sublingual Buprenorphine, and Non-Dependent Controls.
Topics: Administration, Oral; Administration, Sublingual; Buprenorphine; Drug Implants; Female; Humans; Meth | 2017 |
Methadone, Buprenorphine, and Naltrexone for the Treatment of Opioid Use Disorder in Pregnant Women.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naltrexone; | 2017 |
Maternal Use of Opioids During Pregnancy and Congenital Malformations: A Systematic Review.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Female; Humans; Methadone; Morphine Derivatives; Op | 2017 |
Treatment of Perinatal Opioid Use Disorder.
Topics: Adult; Analgesics, Opioid; Decision Making; Female; Humans; Infant, Newborn; Methadone; Neonatal Abs | 2018 |
Opioid Detoxification in Pregnancy: Systematic Review and Meta-Analysis of Perinatal Outcomes.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S | 2019 |
Neonatal abstinence syndrome.
Topics: Adult; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opiate Subs | 2018 |
Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis.
Topics: Child; Child Development; Child, Preschool; Female; Humans; Infant; Methadone; Narcotics; Opioid-Rel | 2019 |
Morphine and Methadone for Neonatal Abstinence Syndrome: A Systematic Review.
Topics: Analgesics, Opioid; Female; Humans; Infant; Infant, Newborn; Length of Stay; Male; Methadone; Morphi | 2018 |
Opioid use disorder during pregnancy: An overview.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Cognitive Behavioral Therapy; Female; Fetal Di | 2019 |
Pharmacological treatment of opioid use disorder in pregnancy.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Guidelines as Topic; Humans; Methadone; Narcotic A | 2019 |
Post-cesarean delivery pain. Management of the opioid-dependent patient before, during and after cesarean delivery.
Topics: Analgesia, Patient-Controlled; Buprenorphine; Cesarean Section; Female; Humans; Methadone; Naltrexon | 2019 |
Analgesia, Opioids, and Other Drug Use During Pregnancy and Neonatal Abstinence Syndrome.
Topics: Analgesia, Obstetrical; Analgesics; Analgesics, Opioid; Breast Feeding; Buprenorphine; Buprenorphine | 2019 |
Management and monitoring of opioid use in pregnancy.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Maternal-Fetal Exchange; Methadone; Narcot | 2020 |
Consideration of opioid agonist treatment in a pregnant adolescent: A case report and literature review.
Topics: Adolescent; Ambulatory Care; Analgesics, Opioid; Buprenorphine; Child, Foster; Female; Humans; Lost | 2020 |
Chronic opioid use during pregnancy: maternal and fetal implications.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S | 2013 |
Managing opioid dependence in pregnancy -- a general practice perspective.
Topics: Adult; Buprenorphine; Female; General Practice; Humans; Methadone; Narcotics; Neonatal Abstinence Sy | 2013 |
Medication-assisted treatment with methadone: assessing the evidence.
Topics: Analgesics, Opioid; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorde | 2014 |
Maintenance agonist treatments for opiate-dependent pregnant women.
Topics: Birth Weight; Buprenorphine; Delayed-Action Preparations; Female; Humans; Infant; Infant, Newborn; M | 2013 |
Buprenorphine and methadone for opioid addiction during pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Drug Administration Schedule; Female; Humans; Methadone; Neonatal | 2014 |
Neonatal opioid withdrawal syndrome.
Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Infant, Newborn; Male; Methadone; | 2014 |
Prenatal buprenorphine versus methadone exposure and neonatal outcomes: systematic review and meta-analysis.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Models, Statistical; Neonatal Abstinence | 2014 |
Review of the assessment and management of neonatal abstinence syndrome.
Topics: Breast Feeding; Buprenorphine; Clonidine; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neo | 2014 |
Medication assisted treatment discontinuation in pregnant and postpartum women with opioid use disorder.
Topics: Buprenorphine; Female; Humans; Kaplan-Meier Estimate; Methadone; Narcotic Antagonists; Narcotics; Op | 2015 |
Question: is breastfeeding useful in the management of neonatal abstinence syndrome?
Topics: Breast Feeding; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; | 2015 |
Pharmacological Management of Opioid Use Disorder in Pregnant Women.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Opiate Subst | 2015 |
Buprenorphine Versus Methadone for Opioid Dependence in Pregnancy.
Topics: Buprenorphine; Female; Humans; Infant; Infant, Newborn; Length of Stay; Methadone; Neonatal Abstinen | 2016 |
Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Fetal Death; F | 2016 |
Long-Term Outcomes of Infants with Neonatal Abstinence Syndrome.
Topics: Analgesics, Opioid; Child Abuse; Epigenesis, Genetic; Female; Humans; Infant, Newborn; Methadone; Ne | 2016 |
Opioid dependence and pregnancy: minimizing stress on the fetal brain.
Topics: Brain Diseases; Buprenorphine; Female; Fetal Diseases; Humans; Methadone; Opioid-Related Disorders; | 2017 |
Neonatal Abstinence Syndrome.
Topics: Female; Humans; Incidence; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Syndrome; Opiat | 2016 |
Pregnancy and injecting drug use.
Topics: Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Patient Care Planning; Pregnancy; Pr | 2008 |
Treating pregnant women dependent on opioids is not the same as treating pregnancy and opioid dependence: a knowledge synthesis for better treatment for women and neonates.
Topics: Buprenorphine; Diagnosis, Dual (Psychiatry); Female; GABA Modulators; Humans; Infant, Newborn; Menta | 2008 |
Methadone exposure during lactation.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Lactation; Maternal Exposure; | 2008 |
The management of heroin misuse in pregnancy: time for a rethink?
Topics: Buprenorphine; Child, Preschool; Developmental Disabilities; Female; Heroin Dependence; Humans; Infa | 2011 |
Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis.
Topics: Cohort Studies; Databases, Bibliographic; Dose-Response Relationship, Drug; Female; Humans; Infant, | 2010 |
Drug interactions associated with methadone, buprenorphine, cocaine, and HIV medications: implications for pregnant women.
Topics: Anti-HIV Agents; Buprenorphine; Cocaine; Drug Interactions; Female; HIV Infections; Humans; Methadon | 2011 |
[Pregnant opioid addicted patients and additional drug intake. Part I. Toxic effects and therapeutic consequences].
Topics: Adult; Alcoholism; Central Nervous System Stimulants; Drug Monitoring; Female; Heroin Dependence; Hu | 2011 |
Management of opioid substitution therapy during medical intervention.
Topics: Analgesics; Australia; Buprenorphine; Comorbidity; Drug Interactions; Female; Humans; Liver Diseases | 2012 |
Naltrexone in the treatment of opioid-dependent pregnant women: the case for a considered and measured approach to research.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naltrexone; Narcotic Antagonists; Narcoti | 2013 |
Methadone and buprenorphine for the management of opioid dependence in pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review.
Topics: Buprenorphine; Child Development; Female; Fetus; Humans; Infant, Newborn; Length of Stay; Methadone; | 2012 |
Opioid addiction in pregnancy.
Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neona | 2012 |
Pharmacologic management of neonatal abstinence syndrome in a community hospital.
Topics: Analgesics, Opioid; Female; Florida; Humans; Infant, Newborn; Intensive Care, Neonatal; Length of St | 2013 |
Neonatal abstinence syndrome: treatment and pediatric outcomes.
Topics: Developmental Disabilities; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinen | 2013 |
The effect of abused substances on antenatal and intrapartum fetal testing and well-being.
Topics: Alcohol Drinking; Biophysical Phenomena; Blood Flow Velocity; Cocaine; Female; Fetal Movement; Heart | 2013 |
Chronic and acute pain and pain management for patients in methadone maintenance treatment.
Topics: Acute Pain; Analgesics; Catastrophization; Chronic Pain; Drug Tolerance; Female; Humans; Methadone; | 2013 |
[Is buprenorphine a potential alternative to methadone for treating pregnant drug users? Inventory of clinical data in the literature].
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Narcotic Antagonists; Narcotics; Neonatal | 2002 |
[Therapeutic strategies for opioid addiction: the role of substitution therapy].
Topics: Buprenorphine; Female; Humans; Mental Disorders; Methadone; Narcotic Antagonists; Narcotics; Opioid- | 2004 |
Methadone and buprenorphine treatment during pregnancy: what are the effects on infants?
Topics: Analgesics, Opioid; Buprenorphine; Female; Fetus; Humans; Infant, Low Birth Weight; Infant, Newborn; | 2007 |
Treatment of opioid-dependent pregnant women: clinical and research issues.
Topics: Analgesics, Opioid; Buprenorphine; Clinical Trials as Topic; Decision Making; Female; Humans; Infant | 2008 |
Maintenance agonist treatments for opiate dependent pregnant women.
Topics: Birth Weight; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Methadone; Narcotics; Opioid-R | 2008 |
Infants of drug-dependent mothers.
Topics: Abnormalities, Drug-Induced; Female; Fetal Alcohol Spectrum Disorders; Fetal Growth Retardation; Her | 1983 |
Effects of in-utero opiate exposure: new paradigms for old questions.
Topics: Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related | 1994 |
Methadone during pregnancy: the search for a valid animal model.
Topics: Animals; Behavior, Animal; Child; Child, Preschool; Disease Models, Animal; Female; Heroin Dependenc | 1993 |
Pharmacotherapy for opioid and cocaine abuse.
Topics: Antidepressive Agents; Cocaine; Dopamine Agonists; Female; Humans; Methadone; Narcotic Antagonists; | 1997 |
Helping patients who misuse drugs.
Topics: Central Nervous System Depressants; Family Practice; Female; Humans; Methadone; Narcotics; Opioid-Re | 1997 |
The relationship between maternal use of heroin and methadone and infant birth weight.
Topics: Birth Weight; Female; Heroin; Humans; Infant, Low Birth Weight; Infant, Newborn; Methadone; Opioid-R | 1997 |
Opioid dependence during pregnancy. Effects and management.
Topics: Delivery, Obstetric; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Synd | 1998 |
Assessing the relationship between maternal opiate use and neonatal mortality.
Topics: Female; Heroin; Humans; Infant Mortality; Infant, Newborn; Methadone; Narcotics; Opioid-Related Diso | 1998 |
Methadone in the management of narcotic addiction in pregnancy.
Topics: Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 1998 |
[Substitution therapy of drug addicts].
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Pregnancy; Pregnancy Complications; Pr | 1998 |
Early development of infants exposed to drugs prenatally.
Topics: Alcoholism; Child Abuse; Child Development; Child, Preschool; Cocaine; Cocaine-Related Disorders; Et | 1999 |
The methadone-maintained pregnancy.
Topics: Comprehensive Health Care; Delivery, Obstetric; Embryonic and Fetal Development; Family Health; Fema | 1999 |
[Pregnancy and drug abuse: current situation and therapeutic strategies].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Female; Fetal Growth Retardation; Hepatit | 2000 |
Treatment of neonatal abstinence syndrome with breast milk containing methadone.
Topics: Breast Feeding; Drug Administration Schedule; Female; Humans; Infant, Newborn; Labor, Obstetric; Met | 2002 |
Clinical management of methadone dependence during pregnancy.
Topics: Female; Fetus; Humans; Infant, Newborn; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Co | 2001 |
The effect of maternal narcotic addiction on the newborn infant.
Topics: Abnormalities, Drug-Induced; Breast Feeding; Female; Fertility; Heroin Dependence; Humans; Infant Mo | 1977 |
[Findings in newborn infants following drug abuse or drug weaning in the mother].
Topics: Abnormalities, Drug-Induced; Adult; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Inf | 1991 |
Narcotic use in pregnancy.
Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complications; Prevalence; | 1991 |
Treatment perspectives in drug misuse: the opiate paradigm.
Topics: Endorphins; Female; History, 18th Century; History, 19th Century; History, 20th Century; Humans; Mal | 1987 |
The drug user as a parent.
Topics: Child Development; Child Rearing; Child, Preschool; Curriculum; Female; Humans; Infant; Infant, Newb | 1985 |
Methadone.
Topics: Acetates; Administration, Oral; Adolescent; American Medical Association; Canada; Chemical Phenomena | 1973 |
38 trials available for methadone and Complications, Pregnancy
| Article | Year |
|---|---|
Neonatal Abstinence Syndrome Severity Index Predicts 18-Month Neurodevelopmental Outcome in Neonates Randomized to Morphine or Methadone.
Topics: Analgesics, Opioid; Cluster Analysis; Female; Humans; Infant; Infant, Newborn; Length of Stay; Male; | 2020 |
Randomized Clinical Trial of Standard- Versus High-Calorie Formula for Methadone-Exposed Infants: A Feasibility Study.
Topics: Double-Blind Method; Energy Intake; Feasibility Studies; Female; Humans; Infant Formula; Infant, New | 2018 |
Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes.
Topics: Adult; Buprenorphine; Child Development; Child, Preschool; Cognition; Female; Humans; Infant, Newbor | 2018 |
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual | 2013 |
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual | 2013 |
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual | 2013 |
Induction of pregnant women onto opioid-agonist maintenance medication: an analysis of withdrawal symptoms and study retention.
Topics: Adult; Analysis of Variance; Buprenorphine; Confidence Intervals; Diagnostic and Statistical Manual | 2013 |
Nonserious adverse events in randomized trials with opioid-dependent pregnant women: direct versus indirect measurement.
Topics: Analgesics, Opioid; Buprenorphine; Data Collection; Double-Blind Method; Female; Humans; Infant, New | 2012 |
Design considerations for point-of-care clinical trials comparing methadone and buprenorphine treatment for opioid dependence in pregnancy and for neonatal abstinence syndrome.
Topics: Adult; Birth Weight; Buprenorphine; Female; Humans; Infant, Newborn; Length of Stay; Methadone; Neon | 2014 |
The effect of prenatal alcohol co-exposure on neonatal abstinence syndrome in infants born to mothers in opioid maintenance treatment.
Topics: Adult; Alcohol Drinking; Female; Humans; Incidence; Infant, Newborn; Length of Stay; Methadone; Neon | 2016 |
Psychometric assessment of the Neonatal Abstinence Scoring System and the MOTHER NAS Scale.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Absti | 2016 |
Newborn birth-weight of pregnant women on methadone or buprenorphine maintenance treatment: A national contingency management approach trial.
Topics: Adult; Age of Onset; Alcohol Drinking; Birth Weight; Buprenorphine; Cigarette Smoking; Female; Human | 2017 |
Maternal methadone dosing schedule and fetal neurobehaviour.
Topics: Adult; Behavior; Cognition; Drug Administration Schedule; Female; Fetal Monitoring; Fetal Movement; | 2009 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
Neonatal abstinence syndrome after methadone or buprenorphine exposure.
Topics: Adult; Buprenorphine; Double-Blind Method; Female; Head; History, Ancient; Humans; Infant, Newborn; | 2010 |
(R)- and (S)-methadone and buprenorphine concentration ratios in maternal and umbilical cord plasma following chronic maintenance dosing in pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Drug Administration Schedule; Female; Fetal Blood; Humans; Infant | 2010 |
Maternal methadone dose, placental methadone concentrations, and neonatal outcomes.
Topics: Analgesics, Opioid; Apgar Score; Birth Weight; Body Size; Cephalometry; Cocaine; Female; Gestational | 2011 |
Treating the partners of opioid-dependent pregnant patients: feasibility and efficacy.
Topics: Adult; Counseling; Feasibility Studies; Female; Humans; Interpersonal Relations; Interview, Psycholo | 2011 |
Randomized controlled trials in pregnancy: scientific and ethical aspects. Exposure to different opioid medications during pregnancy in an intra-individual comparison.
Topics: Adult; Analgesics, Opioid; Birth Weight; Buprenorphine; Double-Blind Method; Female; Humans; Infant, | 2011 |
Buprenorphine versus methadone in pregnant opioid-dependent women: a prospective multicenter study.
Topics: Adult; Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Heroin; Heroin Dependence; Humans; I | 2011 |
Methadone, cocaine, opiates, and metabolite disposition in umbilical cord and correlations to maternal methadone dose and neonatal outcomes.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Cocaine; Dose-Response Relationship, Drug; Female; Humans; | 2011 |
Impact of treatment approach on maternal and neonatal outcome in pregnant opioid-maintained women.
Topics: Adult; Austria; Birth Weight; Buprenorphine; Double-Blind Method; Female; Gestational Age; Humans; I | 2011 |
Are male neonates more vulnerable to neonatal abstinence syndrome than female neonates?
Topics: Birth Weight; Buprenorphine; Double-Blind Method; Female; Humans; Infant, Newborn; Male; Methadone; | 2011 |
Influence of site differences between urban and rural American and Central European opioid-dependent pregnant women and neonatal outcome characteristics.
Topics: Adolescent; Adult; Buprenorphine; Double-Blind Method; Europe; Female; Humans; Infant, Newborn; Meth | 2012 |
Contingent incentives reduce cigarette smoking among pregnant, methadone-maintained women: results of an initial feasibility and efficacy randomized clinical trial.
Topics: Adult; Behavior Therapy; Carbon Monoxide; Feasibility Studies; Female; Humans; Methadone; Motivation | 2012 |
Illicit drug use among pregnant women enrolled in treatment for cigarette smoking cessation.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Cannabis; Cocaine; Demography; Female; Humans; Illicit D | 2013 |
Maternal Opioid Treatment: Human Experimental Research (MOTHER) Study: maternal, fetal and neonatal outcomes from secondary analyses.
Topics: Adolescent; Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Sy | 2012 |
Fetal assessment before and after dosing with buprenorphine or methadone.
Topics: Adolescent; Adult; Analgesics, Opioid; Biophysical Phenomena; Buprenorphine; Double-Blind Method; Fe | 2012 |
Predicting treatment for neonatal abstinence syndrome in infants born to women maintained on opioid agonist medication.
Topics: Adolescent; Adult; Analgesics, Opioid; Birth Weight; Buprenorphine; Dose-Response Relationship, Drug | 2012 |
Differences in the profile of neonatal abstinence syndrome signs in methadone- versus buprenorphine-exposed neonates.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Buprenorphine; Double-Blind Method; Female; Humans; | 2012 |
Neonatal neurobehavior effects following buprenorphine versus methadone exposure.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Infant Behavior; Infant, Newbo | 2012 |
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind | 2012 |
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind | 2012 |
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind | 2012 |
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind | 2012 |
Infections and obstetric outcomes in opioid-dependent pregnant women maintained on methadone or buprenorphine.
Topics: Adolescent; Adult; Analgesics, Opioid; Analysis of Variance; Buprenorphine; Communicable Diseases; F | 2012 |
Lessons learned from a comparison of evidence-based research in pregnant opioid-dependent women.
Topics: Adolescent; Adult; Buprenorphine; Double-Blind Method; Evidence-Based Medicine; Female; Humans; Infa | 2013 |
Motivational enhancement therapy for nicotine dependence in methadone-maintained pregnant women.
Topics: Adolescent; Adult; Analysis of Variance; Female; Humans; Linear Models; Methadone; Motivation; Opioi | 2004 |
Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome.
Topics: Administration, Sublingual; Adult; Buprenorphine; Double-Blind Method; Female; Heroin Dependence; Hu | 2005 |
Methadone versus buprenorphine in pregnant addicts: a double-blind, double-dummy comparison study.
Topics: Buprenorphine; Double-Blind Method; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence | 2006 |
Management of neonatal abstinence syndrome in neonates born to opioid maintained women.
Topics: Adult; Apgar Score; Female; Gestational Age; Humans; Infant, Newborn; Male; Methadone; Morphine; Neo | 2007 |
Methadone dosing and pregnancy: impact on program compliance.
Topics: Ambulatory Care; Cocaine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hu | 1995 |
Evaluation of a cognitive-behavioural intervention for pregnant injecting drug users at risk of HIV infection.
Topics: Adult; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Follow-Up Studies; Health Kn | 1996 |
The effectiveness of incentives in enhancing treatment attendance and drug abstinence in methadone-maintained pregnant women.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Cocaine-Related Disorders; Female; Heroin Depe | 2001 |
[Withdrawal syndromes of newborns of pregnant drug abusers maintained under methadone or high-dose buprenorphine: 246 cases].
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Ab | 2001 |
368 other studies available for methadone and Complications, Pregnancy
| Article | Year |
|---|---|
Opioid Use Disorder and Perinatal Outcomes.
Topics: Adult; Analgesics, Opioid; British Columbia; Buprenorphine; Female; Humans; Incidence; Infant, Newbo | 2021 |
A retrospective, observational study on medication for opioid use disorder during pregnancy and risk for neonatal abstinence syndrome.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal Abst | 2022 |
Histological Changes Observed in Placentas Exposed to Medication-Assisted Treatment.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Opiate Substitution Treatment; Placenta; | 2021 |
Trends in the severity of opioid use disorder during pregnancy over time.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid- | 2022 |
Buprenorphine uptake during pregnancy following the 2017 guidelines update on prenatal opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid- | 2022 |
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I | 2022 |
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I | 2022 |
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I | 2022 |
Buprenorphine versus Methadone for Opioid Use Disorder in Pregnancy.
Topics: Buprenorphine; Cesarean Section; Cohort Studies; Female; Humans; Infant; Infant, Low Birth Weight; I | 2022 |
Buprenorphine-naloxone, buprenorphine, and methadone throughout pregnancy in maternal opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Illicit | 2023 |
How does a clinician approach the pharmacological management of opioid use disorders in pregnant women and pregnant people?
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid- | 2023 |
Comparative Safety Analysis of Opioid Agonist Treatment in Pregnant Women with Opioid Use Disorder: A Population-Based Study.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S | 2023 |
Trends in smoking during pregnancy stratified by the use of opioid agonist therapy and the contribution of smoking to poor outcome in neonates prenatally exposed to opioid agonist treatment.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Opiate Substitution T | 2023 |
Prenatal exposure to opioid maintenance treatment and neonatal outcomes: Nationwide registry studies from the Czech Republic and Norway.
Topics: Adult; Buprenorphine; Child Development; Czech Republic; Female; Humans; Infant, Newborn; Logistic M | 2019 |
Drug screening during pregnancy: Urine dip cups measure up.
Topics: Amphetamines; Analgesics, Opioid; Benzodiazepines; Buprenorphine; Cocaine; Female; Humans; Laborator | 2019 |
Methadone, Buprenorphine, or Detoxification for Management of Perinatal Opioid Use Disorder: A Cost-Effectiveness Analysis.
Topics: Buprenorphine; Cost-Benefit Analysis; Decision Support Techniques; Female; Humans; Methadone; Narcot | 2019 |
Necrotizing enterocolitis and its association with the neonatal abstinence syndrome.
Topics: Analgesics, Opioid; Buprenorphine; Cohort Studies; Enterocolitis, Necrotizing; Female; Fetal Blood; | 2020 |
Pregnant Smokers Receiving Opioid Agonist Therapy Have an Elevated Nicotine Metabolite Ratio: A Replication Study.
Topics: Analgesics, Opioid; Bupropion; Cotinine; Female; Humans; Methadone; Nicotine; Opiate Substitution Tr | 2020 |
Assessment of Racial and Ethnic Disparities in the Use of Medication to Treat Opioid Use Disorder Among Pregnant Women in Massachusetts.
Topics: Adult; Black or African American; Buprenorphine; Female; Healthcare Disparities; Hispanic or Latino; | 2020 |
Comparison of buprenorphine and methadone in the management of maternal opioid use disorder in full term pregnancies.
Topics: Birth Weight; Buprenorphine; Delivery, Obstetric; Female; Humans; Infant, Newborn; Length of Stay; M | 2020 |
Adverse neonatal outcomes associated with maternal severe mental health diagnoses and opioid use.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Mental Health; Methadone; Neonat | 2020 |
Drug abuse during pregnancy and its neonatal impact. Analysis of the periods 2002-2008 and 2009-2017.
Topics: Cocaine; Female; Humans; Infant, Newborn; Methadone; Methamphetamine; Pregnancy; Pregnancy Complicat | 2021 |
Prevalence and Geographic Distribution of Obstetrician-Gynecologists Who Treat Medicaid Enrollees and Are Trained to Prescribe Buprenorphine.
Topics: Adult; Buprenorphine; Cross-Sectional Studies; Female; Humans; Infant, Newborn; Male; Medicaid; Meth | 2020 |
Delivery dose of methadone, but not buprenorphine, is associated with the risk and severity of neonatal opiate withdrawal syndrome.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Pregnancy; Pregnancy Complications; Prosp | 2020 |
Neonatal abstinence syndrome in neonates born of mothers in drug-assisted rehabilitation.
Topics: Female; Humans; Infant; Infant, Newborn; Methadone; Mothers; Neonatal Abstinence Syndrome; Norway; O | 2021 |
Prenatal methadone exposure and child developmental outcomes in 2-year-old children.
Topics: Adult; Child Development; Child, Preschool; Confounding Factors, Epidemiologic; Female; Humans; Infa | 2021 |
Prenatal methadone exposure disrupts behavioral development and alters motor neuron intrinsic properties and local circuitry.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Brain; Female; Humans; Male; Maternal Exposure; Metha | 2021 |
Conceptualizing stigma in contexts of pregnancy and opioid misuse: A qualitative study with women and healthcare providers in Ohio.
Topics: Adult; Buprenorphine; Female; Health Personnel; Humans; Infant, Newborn; Methadone; Neonatal Abstine | 2021 |
Leveraging Telehealth in the United States to Increase Access to Opioid Use Disorder Treatment in Pregnancy and Postpartum During the COVID-19 Pandemic.
Topics: Adult; Buprenorphine; Comorbidity; Comprehensive Health Care; COVID-19; Delivery of Health Care; Evi | 2021 |
Impact of opioid maintenance treatment during pregnancy on neonatal birth weight and head circumference.
Topics: Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Male; Meth | 2021 |
Methadone and buprenorphine discontinuation among postpartum women with opioid use disorder.
Topics: Adult; Analgesics, Opioid; Black or African American; Buprenorphine; Correctional Facilities; Ethnic | 2021 |
Outcomes associated with the use of medications for opioid use disorder during pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant; Infant, Newborn; Methadone; Neonatal Abst | 2021 |
Nail disease in neonatal abstinence syndrome.
Topics: Female; Humans; Infant; Infant, Newborn; Male; Methadone; Nail Diseases; Neonatal Abstinence Syndrom | 2021 |
Racial inequity in methadone dose at delivery in pregnant women with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid- | 2021 |
Can buprenorphine be used for opioid use disorder during pregnancy?
Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P | 2021 |
Variations in Infant CYP2B6 Genotype Associated with the Need for Pharmacological Treatment for Neonatal Abstinence Syndrome in Infants of Methadone-Maintained Opioid-Dependent Mothers.
Topics: Adult; Analgesics, Opioid; Cohort Studies; Cytochrome P-450 CYP2B6; Female; Genetic Variation; Human | 2017 |
Infants Born to Opioid-Dependent Women in Ontario, 2002-2014.
Topics: Adult; Buprenorphine; Congenital Abnormalities; Databases, Factual; Female; Health Care Costs; Human | 2017 |
A Retrospective Cohort Study of Birth Outcomes in Neonates Exposed to Naltrexone in Utero: A Comparison with Methadone-, Buprenorphine- and Non-opioid-Exposed Neonates.
Topics: Adult; Australia; Buprenorphine; Drug Administration Routes; Female; Humans; Incidence; Infant, Newb | 2017 |
Sensorimotor outcomes in children with prenatal exposure to methadone.
Topics: Age of Onset; Exotropia; Female; Humans; Infant; Methadone; Narcotics; Neonatal Abstinence Syndrome; | 2017 |
Association of methadone dose with substance use and treatment retention in pregnant and postpartum women with opioid use disorder.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Methadone; Opiate Subst | 2017 |
Transitioning from methadone to buprenorphine maintenance in management of opioid use disorder during pregnancy.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Substitution; Female; Humans; Infant, Newborn; Methad | 2018 |
Increased DNA Methylation of ABCB1, CYP2D6, and OPRM1 Genes in Newborn Infants of Methadone-Maintained Opioid-Dependent Mothers.
Topics: Adult; Analgesics, Opioid; ATP Binding Cassette Transporter, Subfamily B; Case-Control Studies; Coho | 2017 |
Maternal buprenorphine treatment and infant outcome.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opiate Subs | 2017 |
Buprenorphine for the Neonatal Abstinence Syndrome.
Topics: Buprenorphine; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opiate Substitution | 2017 |
Buprenorphine for the Neonatal Abstinence Syndrome.
Topics: Buprenorphine; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opiate Substitution | 2017 |
Buprenorphine for the Neonatal Abstinence Syndrome.
Topics: Buprenorphine; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opiate Substitution | 2017 |
Buprenorphine for the Neonatal Abstinence Syndrome.
Topics: Buprenorphine; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opiate Substitution | 2017 |
Antenatal methadone vs buprenorphine exposure and length of hospital stay in infants admitted to the intensive care unit with neonatal abstinence syndrome.
Topics: Adult; Buprenorphine; Female; Gestational Age; Humans; Infant, Newborn; Intensive Care Units, Neonat | 2018 |
Medicaid Coverage of Methadone Maintenance and the Use of Opioid Agonist Therapy Among Pregnant Women in Specialty Treatment.
Topics: Adult; Cross-Sectional Studies; Eligibility Determination; Female; Health Services Accessibility; Hu | 2017 |
Invited Commentary: A Novel Strategy for Addressing Unmeasured Confounding When Comparing Opioid Agonist Therapies in Pregnancy.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Medicaid; Methadone; Opiate Substitution Treatment; | 2018 |
Neonatal Outcomes in a Medicaid Population With Opioid Dependence.
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Narcotics; Opioid-Related Disorders; Preg | 2018 |
Neonatal outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway.
Topics: Abortion, Spontaneous; Adult; Analgesics, Opioid; Apgar Score; Buprenorphine; Czech Republic; Female | 2018 |
Treating women with opioid use disorder during pregnancy in Appalachia: Initial neonatal outcomes following buprenorphine + naloxone exposure.
Topics: Adult; Appalachian Region; Birth Weight; Buprenorphine, Naloxone Drug Combination; Female; Humans; I | 2018 |
Pregnancy and the Opioid Epidemic.
Topics: Analgesics, Opioid; Epidemics; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndr | 2018 |
Opioid Utilization by Pregnant Women with Sickle Cell Disease and the Risk of Neonatal Abstinence Syndrome.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Case-Control Studies; Female; Humans; Incidence; Met | 2018 |
Barriers to accessing treatment for pregnant women with opioid use disorder in Appalachian states.
Topics: Analgesics, Opioid; Appalachian Region; Buprenorphine; Female; Health Expenditures; Health Personnel | 2019 |
Fatal and Nonfatal Overdose Among Pregnant and Postpartum Women in Massachusetts.
Topics: Adult; Buprenorphine; Drug Overdose; Female; Humans; Massachusetts; Methadone; Opiate Substitution T | 2018 |
Prenatal Treatment and Outcomes of Women With Opioid Use Disorder.
Topics: Adult; Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disor | 2018 |
Buprenorphine medication-assisted treatment during pregnancy: An exploratory factor analysis associated with adherence.
Topics: Adult; Buprenorphine; Factor Analysis, Statistical; Female; Humans; Infant, Newborn; Medication Adhe | 2018 |
Impact of timing of methadone initiation on perinatal outcomes following delivery among pregnant women on methadone maintenance therapy in Ontario.
Topics: Adolescent; Adult; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Methadone; Midd | 2019 |
Could prenatal food insecurity influence neonatal abstinence syndrome severity?
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Food Supply; Humans; Methadone; Neonatal Abstinenc | 2019 |
Medical specialty of buprenorphine prescribers for pregnant women with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Drug Prescriptions; Female; Humans; Medicaid; Methadone; Opiate S | 2019 |
Hospitalization of children after prenatal exposure to opioid maintenance therapy during pregnancy: a national registry study from the Czech Republic.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Case-Control Studies; Child, Preschool; Czech Republic; Di | 2019 |
Implications of perinatal buprenorphine exposure on infant head circumference at birth.
Topics: Buprenorphine; Female; Humans; Infant; Infant, Newborn; Male; Methadone; Neonatal Abstinence Syndrom | 2021 |
Medication-Assisted Treatment Use Among Pregnant Women With Opioid Use Disorder.
Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine; Cohort Studies; Databases, Factual; Female; Hu | 2019 |
Factors associated with treatment retention in pregnant women with opioid use disorders prescribed methadone or electing non-pharmacological treatment.
Topics: Adult; Baltimore; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders | 2020 |
Interventions for the Treatment of Neonatal Abstinence Syndrome.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Male; Methadone; Morphine; Neona | 2019 |
Treating perinatal opioid use disorder in rural settings: Challenges and opportunities.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; New Hampshire; Opiate Substitut | 2019 |
Prevalence of Maternal-Risk Factors Related to Neonatal Abstinence Syndrome in a Commercial Claims Database: 2011-2015.
Topics: Adult; Analgesics, Opioid; Drug Prescriptions; Female; Humans; Incidence; Infant, Newborn; Insurance | 2019 |
Use of naltrexone in treating opioid use disorder in pregnancy.
Topics: Abortion, Spontaneous; Adult; Analgesics, Opioid; Buprenorphine; Case-Control Studies; Female; Human | 2020 |
Treating opioid use disorders during pregnancy: historical, current, and future directions.
Topics: Buprenorphine; Disease Management; Female; History, 19th Century; History, 20th Century; History, 21 | 2013 |
Trends in the average prescribed dose of methadone: more than a proxy for the evolution of severity of opioid dependence.
Topics: Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 2013 |
Re: Letter from J. Trujols, N. Siñol & J. Pérez De Los Cobos.
Topics: Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 2013 |
The obstetrical and neonatal impact of maternal opioid detoxification in pregnancy.
Topics: Adult; Cohort Studies; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opi | 2013 |
In utero drug and alcohol exposure in infants born to mothers prescribed maintenance methadone.
Topics: Analgesics, Opioid; Central Nervous System Depressants; Ethanol; Female; Humans; Illicit Drugs; Infa | 2013 |
Clinical care for opioid-using pregnant and postpartum women: the role of obstetric providers.
Topics: Analgesics, Opioid; Buprenorphine; Confidentiality; Dose-Response Relationship, Drug; Emergency Serv | 2014 |
Integrated care for pregnant women on methadone maintenance treatment: Canadian primary care cohort study.
Topics: Adolescent; Adult; Analgesics, Opioid; Canada; Cohort Studies; Delivery of Health Care, Integrated; | 2013 |
Effectiveness of a clinical pathway with methadone treatment protocol for treatment of neonatal abstinence syndrome following in utero drug exposure to substances of abuse*.
Topics: Analgesics, Opioid; Clinical Protocols; Female; Humans; Infant, Newborn; Intensive Care Units, Neona | 2014 |
Reply: To PMID 23727040.
Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 2014 |
The obstetric and neonatal impact of maternal opioid detoxification in pregnancy.
Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 2014 |
Reduced fetal growth in methadone-maintained pregnancies is not fully explained by smoking or socio-economic deprivation.
Topics: Adult; Analgesics, Opioid; Birth Weight; Cohort Studies; Female; Fetal Growth Retardation; Head; Hum | 2014 |
Searching the right way to treat neonatal abstinence syndrome*.
Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregna | 2014 |
Commentary on Mactier et al. (2014): Methadone-assisted treatment and the complexity of influences on fetal development.
Topics: Analgesics, Opioid; Birth Weight; Female; Fetal Growth Retardation; Humans; Male; Methadone; Opioid- | 2014 |
Neonatal abstinence syndrome: on the evidence to add breastfeeding to any clinical pathway.
Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregna | 2014 |
The authors reply.
Topics: Analgesics, Opioid; Female; Humans; Male; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregna | 2014 |
Comparison of adverse obstetric outcomes and maternity hospitalization among heroin-exposed and methadone-treated women in Taiwan.
Topics: Adult; Cohort Studies; Female; Heroin Dependence; Hospitalization; Humans; Length of Stay; Methadone | 2015 |
Management of neonatal abstinence syndrome in the newborn nursery.
Topics: Female; Humans; Infant, Newborn; Methadone; Mother-Child Relations; Neonatal Abstinence Syndrome; Pr | 2014 |
Buprenorphine and naloxone compared with methadone treatment in pregnancy.
Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naloxone; Narcotic Antagonists; Na | 2015 |
Buprenorphine and naloxone compared with methadone treatment in pregnancy.
Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naloxone; Narcotic Antagonists; Na | 2015 |
Buprenorphine and naloxone compared with methadone treatment in pregnancy.
Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naloxone; Narcotic Antagonists; Na | 2015 |
Buprenorphine and naloxone compared with methadone treatment in pregnancy.
Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naloxone; Narcotic Antagonists; Na | 2015 |
Maternal Substance Use and Neonatal Abstinence Syndrome: A Descriptive Study.
Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Length of Stay; Methadone; Mothers; Neonatal Abs | 2015 |
First Dutch national guidelines--pharmacological care for detained opioid addicts.
Topics: Buprenorphine; Communicable Diseases; Comorbidity; Continuity of Patient Care; Female; Health Policy | 2009 |
Caring for Opioid-dependent Pregnant Women: Prenatal and Postpartum Care Considerations.
Topics: Alcohol-Related Disorders; Breast Feeding; Counseling; Female; Humans; Incidence; Infant, Newborn; M | 2015 |
Maternal methadone treatment and neonatal abstinence syndrome.
Topics: Female; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Length of Stay; Logistic Models | 2015 |
Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study.
Topics: Adolescent; Adult; Analgesics, Opioid; Cohort Studies; Dose-Response Relationship, Drug; Female; Hum | 2015 |
Obstetrical and neonatal outcomes of methadone-maintained pregnant women: a canadian multisite cohort study.
Topics: Adult; Birth Weight; Breast Feeding; Canada; Female; Gestational Age; Humans; Infant, Newborn; Lengt | 2015 |
Methadone versus buprenorphine for the treatment of opioid abuse in pregnancy: science and stigma.
Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P | 2015 |
Opioid use disorder during pregnancy in Tennessee: expediency vs. science.
Topics: Buprenorphine; Female; Humans; Insurance Coverage; Medicaid; Methadone; Opiate Substitution Treatmen | 2015 |
Caring for pregnant opioid abusers in Vermont: A potential model for non-urban areas.
Topics: Adult; Buprenorphine; Community Health Centers; Female; Health Services Accessibility; Humans; Infan | 2015 |
Neonatal abstinence syndrome: Historical perspective, current focus, future directions.
Topics: Adult; Analgesics, Opioid; Female; History, 19th Century; History, 20th Century; History, 21st Centu | 2015 |
Cohort Analysis of a Pharmacokinetic-Modeled Methadone Weaning Optimization for Neonatal Abstinence Syndrome.
Topics: Adult; Analgesics, Opioid; Cohort Studies; Female; Humans; Infant, Newborn; Length of Stay; Male; Me | 2015 |
Revision of Breastfeeding Guidelines in the Setting of Maternal Opioid Use Disorder: One Institution's Experience.
Topics: Analgesics, Opioid; Boston; Breast Feeding; Buprenorphine; Female; Health Promotion; Humans; Infant, | 2016 |
Rooming-in for Infants at Risk of Neonatal Abstinence Syndrome.
Topics: Adult; Analgesics, Opioid; Bottle Feeding; Breast Feeding; Canada; Female; Humans; Infant, Newborn; | 2016 |
Characteristics of Maternal-Infant Interaction During Treatment for Opioid Withdrawal.
Topics: Adolescent; Adult; Bottle Feeding; Case-Control Studies; Female; Humans; Infant, Newborn; Male; Meth | 2016 |
Neonatal abstinence syndrome and the gastrointestinal tract.
Topics: Analgesics, Opioid; Buprenorphine; Child; Child, Preschool; Dysbiosis; Female; Gastrointestinal Trac | 2016 |
The relationship between gestational age and the severity of neonatal abstinence syndrome.
Topics: Adult; Analgesics, Opioid; Female; Gestational Age; Humans; Infant, Newborn; Intensive Care Units, N | 2017 |
Delayed villous maturation in term placentas exposed to opioid maintenance therapy: a retrospective cohort study.
Topics: Adult; Buprenorphine; Case-Control Studies; Chorionic Villi; Cohort Studies; Female; Humans; Methado | 2017 |
Response to Smith and Brogly et al. commentaries on Zedler et al.
Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P | 2016 |
The comparative safety of buprenorphine versus methadone in pregnancy-what about confounding?
Topics: Buprenorphine; Female; Humans; Methadone; Neonatal Abstinence Syndrome; Opiate Substitution Treatmen | 2016 |
Commentary on Gibson et al. (2017): Gestational age and the severity of neonatal abstinence syndrome.
Topics: Buprenorphine; Gestational Age; Humans; Infant, Newborn; Methadone; Morphine; Neonatal Abstinence Sy | 2017 |
Comparison of characteristics of opioid-using pregnant women in rural and urban settings.
Topics: Adult; Buprenorphine; Demography; Female; Humans; Mass Screening; Methadone; Narcotic Antagonists; O | 2008 |
Chronic hepatitis C in pregnancy.
Topics: Adult; Cholestasis; Comorbidity; Female; Hepatitis C, Chronic; Humans; Infant, Newborn; Methadone; N | 2008 |
Drugs and pregnancy--outcomes of women engaged with a specialist perinatal outreach addictions service.
Topics: Behavior, Addictive; Cross-Sectional Studies; Female; Health Promotion; Humans; London; Methadone; P | 2008 |
Outcome in infants exposed to methadone in utero.
Topics: Developmental Disabilities; Female; Humans; Infant; Infant, Newborn; Methadone; Narcotics; Pregnancy | 2008 |
Maternal and neonatal effects of substance abuse during pregnancy: our ten-year experience.
Topics: Adult; Apgar Score; Birth Weight; Croatia; Female; Heroin; Heroin Dependence; Humans; Incidence; Inf | 2008 |
[Substitution treatment of drug addicts during pregnancy: consequences for the children?].
Topics: Buprenorphine; Developmental Disabilities; Female; Humans; Infant, Newborn; Methadone; Narcotics; Ne | 2009 |
Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources.
Topics: Adolescent; Adult; Breast Feeding; Dose-Response Relationship, Drug; Drug Users; Female; Gestational | 2009 |
Opioid maintenance treatment during pregnancy: occurrence and severity of neonatal abstinence syndrome. A national prospective study.
Topics: Adult; Buprenorphine; Cohort Studies; Female; Humans; Infant, Newborn; Male; Methadone; Neonatal Abs | 2009 |
Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Controlled Clinic | 2009 |
Women treated with methadone are at high risk for poor obstetrical and neonatal outcome.
Topics: Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Sy | 2009 |
The influence of maternal opiate use in pregnancy on second trimester biochemical markers for Down syndrome.
Topics: Adult; Biomarkers; Case-Control Studies; Down Syndrome; Female; Heroin; Humans; Methadone; Opioid-Re | 2009 |
Pregnancy and neonatal characteristics of opioid-dependent Indigenous Australians: a rural and metropolitan comparison.
Topics: Adult; Analgesics, Opioid; Australia; Female; Humans; Infant, Newborn; Methadone; Native Hawaiian or | 2009 |
Patterns in sleep-wakefulness in three-month old infants exposed to methadone or buprenorphine.
Topics: Adult; Buprenorphine; Chronobiology Disorders; Female; Humans; Infant; Infant Behavior; Infant, Newb | 2009 |
Growth restriction in pregnancies of opioid-dependent mothers.
Topics: Adult; Body Mass Index; Dose-Response Relationship, Drug; Epidemiologic Methods; Female; Fetal Growt | 2010 |
Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy.
Topics: Child; Child, Preschool; Evoked Potentials, Visual; Eye Diseases; Female; Humans; Infant; Maternal-F | 2010 |
Multidisciplinary antenatal care for opiate-using women: Child-care issues.
Topics: Appointments and Schedules; Female; Foster Home Care; Heroin; Heroin Dependence; Humans; Infant, New | 2010 |
Relationship between maternal methadone dose at delivery and neonatal abstinence syndrome.
Topics: Cohort Studies; Female; Humans; Incidence; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinenc | 2010 |
Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome.
Topics: Breast Feeding; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Infant, Premature | 2011 |
Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine.
Topics: Analgesics; Animals; Buprenorphine; Disease Models, Animal; Drug Tolerance; Female; Heroin Dependenc | 2010 |
Gender and NAS: does sex matter?
Topics: Analgesics, Opioid; Female; Humans; Infant, Newborn; Male; Methadone; Morphine; Neonatal Abstinence | 2010 |
Perinatal risk factors for the neonatal abstinence syndrome in infants born to women on methadone maintenance therapy.
Topics: Adult; Female; Humans; Infant, Newborn; Logistic Models; Methadone; Narcotics; Neonatal Abstinence S | 2010 |
Postnatal weight loss in substitute methadone-exposed infants: implications for the management of breast feeding.
Topics: Adolescent; Adult; Birth Weight; Bottle Feeding; Breast Feeding; Female; Gestational Age; Humans; In | 2012 |
A special type of 'hard-to-reach' patient: experiences of pregnant women on methadone.
Topics: Female; Humans; Interviews as Topic; Maternal Health Services; Methadone; New Zealand; Opioid-Relate | 2010 |
Prenatal methadone exposure, meconium biomarker concentrations and neonatal abstinence syndrome.
Topics: Adult; Analgesics, Opioid; Cocaine; Cocaine-Related Disorders; Female; Gestational Age; Humans; Infa | 2010 |
Neonatal and maternal outcomes following maternal use of buprenorphine or methadone during pregnancy: findings of a retrospective audit.
Topics: Adult; Buprenorphine; Female; Humans; Infant, Newborn; Maternal Health Services; Maternal Welfare; M | 2011 |
Infant mortality among women on a methadone program during pregnancy.
Topics: Adult; Female; Humans; Infant Mortality; Infant, Newborn; Live Birth; Medical Record Linkage; Methad | 2010 |
Maternal methadone therapy increases QTc interval in newborn infants.
Topics: Case-Control Studies; Electrocardiography; Female; Humans; Infant, Newborn; Long QT Syndrome; Male; | 2011 |
Association between intrapartum fetal heart rate patterns and neonatal abstinence syndrome in methadone exposed neonates.
Topics: Adult; Analgesics, Opioid; Female; Heart Rate, Fetal; Humans; Infant, Newborn; Labor, Obstetric; Mat | 2011 |
Higher maternal doses of methadone does not increase neonatal abstinence syndrome.
Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Methadone; N | 2011 |
Duration of methadone maintenance treatment during pregnancy and pregnancy outcome parameters in women with opiate addiction.
Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Gestational Age; Humans; Infant, Newb | 2012 |
Efficacy versus effectiveness of buprenorphine and methadone maintenance in pregnancy.
Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P | 2011 |
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine | 2012 |
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine | 2012 |
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine | 2012 |
Pregnancies exposed to methadone, methadone and other illicit substances, and poly-drugs without methadone: a comparison of fetal neurobehaviors and infant outcomes.
Topics: Adult; Female; Fetal Monitoring; Humans; Illicit Drugs; Infant, Newborn; Methadone; Neonatal Abstine | 2012 |
A pilot study of the nutritional status of opiate-using pregnant women on methadone maintenance therapy.
Topics: Adult; Body Composition; Body Mass Index; Energy Intake; Fatty Acids, Essential; Female; Humans; Mal | 2012 |
Medication-assisted treatment in criminal justice agencies affiliated with the criminal justice-drug abuse treatment studies (CJ-DATS): availability, barriers, and intentions.
Topics: Adult; Buprenorphine; Crime; Criminal Law; Data Collection; Female; Humans; Male; Methadone; Naltrex | 2012 |
Strength in numbers: a step closer to standardising perinatal care for drug-misusing women and their infants.
Topics: Female; Humans; Methadone; Narcotics; Neonatal Abstinence Syndrome; Opioid-Related Disorders; Pregna | 2012 |
Methadone and perinatal outcomes: a prospective cohort study.
Topics: Adult; Benzodiazepines; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Infant, | 2012 |
Opioid dependency in pregnancy and length of stay for neonatal abstinence syndrome.
Topics: Adult; Buprenorphine; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule | 2012 |
Perinatal effects of combined use of heroin, methadone, and amphetamine during pregnancy and quantitative measurement of metabolites in hair.
Topics: Adult; Amphetamine; Electroencephalography; Female; Fetus; Gas Chromatography-Mass Spectrometry; Hai | 2012 |
Development of a substance abuse program for opioid-dependent nonurban pregnant women improves outcome.
Topics: Buprenorphine; Cohort Studies; Combined Modality Therapy; Female; Health Services Accessibility; Hum | 2012 |
ACOG Committee Opinion No. 524: Opioid abuse, dependence, and addiction in pregnancy.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence S | 2012 |
Maternal and neonatal outcomes following methadone substitution during pregnancy.
Topics: Adult; Analgesics, Opioid; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Premature; Me | 2012 |
Treatment of opioid dependence in the setting of pregnancy.
Topics: Adolescent; Alcohol-Related Disorders; Analgesics, Opioid; Buprenorphine; Child; Comorbidity; Delive | 2012 |
Neurodevelopmental investigation of the mirror neurone system in children of women receiving opioid maintenance therapy during pregnancy.
Topics: Adult; Analysis of Variance; Buprenorphine; Case-Control Studies; Child, Preschool; Developmental Di | 2013 |
Pharmacologic evidence to support clinical decision making for peripartum methadone treatment.
Topics: Adolescent; Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; | 2013 |
Methadone use in pregnancy: evidence of progression in the severity of addiction.
Topics: Adult; England; Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy | 2012 |
Patterns of symptom reporting during pregnancy comparing opioid maintained and control women.
Topics: Adult; Buprenorphine; Case-Control Studies; Female; Humans; Methadone; Opiate Substitution Treatment | 2012 |
Methadone dosing and prescribed medication use in a prospective cohort of opioid-dependent pregnant women.
Topics: Anti-Bacterial Agents; Antidepressive Agents; Benzodiazepines; Female; Humans; Hypnotics and Sedativ | 2013 |
Comments on: Efficacy versus effectiveness of buprenorphine and methadone maintenance in pregnancy.
Topics: Buprenorphine; Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; P | 2012 |
Dual dilemma-should naltrexone be used in the treatment of opioid-dependent pregnant women?
Topics: Buprenorphine; Female; Humans; Infant, Newborn; Methadone; Naltrexone; Narcotic Antagonists; Narcoti | 2013 |
Blocking endogenous opioids during development--do we understand the consequences?
Topics: Animals; Brain; Buprenorphine; Female; Fetal Development; Humans; Methadone; Naltrexone; Narcotic An | 2013 |
Management of the pregnant substance abusing woman.
Topics: Analgesics, Opioid; Female; Humans; Maternal Health Services; Methadone; Opioid-Related Disorders; P | 2013 |
Methadone trough levels in pregnancy.
Topics: Female; Heroin; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; Pregnancy Complic | 2002 |
Maternal methadone dose and neonatal withdrawal.
Topics: Benzodiazepines; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Infant, Newbor | 2003 |
Specialized drug liaison midwife services for pregnant opioid dependent women in Dublin, Ireland.
Topics: Adult; Crime; Female; Humans; Infant, Newborn; Ireland; Mental Disorders; Methadone; Midwifery; Narc | 2004 |
Outcomes of infants born to mothers receiving methadone for pain management in pregnancy.
Topics: Analgesics, Opioid; Chronic Disease; Delivery, Obstetric; Drug Administration Schedule; Female; Gest | 2004 |
["Is opiate detoxification unsafe in pregnancy?"].
Topics: Adult; Female; Humans; Infant, Newborn; Methadone; Narcotics; Opioid-Related Disorders; Pregnancy; P | 2004 |
Methadone maintenance vs. implantable naltrexone treatment in the pregnant heroin user.
Topics: Australia; Drug Implants; Female; Heroin Dependence; Humans; Methadone; Naltrexone; Narcotic Antagon | 2004 |
Does pregnancy affect outcome of methadone maintenance treatment?
Topics: Adult; Case-Control Studies; Comorbidity; Female; Heroin Dependence; Humans; Mental Disorders; Metha | 2004 |
Impact of spinal anaesthesia and obesity on maternal respiratory function during elective Caesarean section.
Topics: Adult; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Body Mass Index; Cesarean Se | 2004 |
Improving the management of opioid-dependent pregnancies.
Topics: Cohort Studies; Dose-Response Relationship, Drug; Female; Gestational Age; Humans; Infant, Newborn; | 2004 |
Challenges that opioid-dependent women present to the obstetric anaesthetist.
Topics: Adult; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Anesthesia, Obstetrical; Cesarean Sect | 2004 |
Methadone maintenance program in a Swiss perinatal center: (I): Management and outcome of 89 pregnancies.
Topics: Adult; Birth Weight; Cocaine-Related Disorders; Cohort Studies; Dose-Response Relationship, Drug; Dr | 2005 |
Methadone maintenance program in pregnancy in a Swiss perinatal center (II): neonatal outcome and social resources.
Topics: Adult; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fetal | 2005 |
High-dose methadone maintenance in pregnancy: maternal and neonatal outcomes.
Topics: Adult; Analgesics, Opioid; Female; Gestational Age; Humans; Infant, Newborn; Length of Stay; Methado | 2005 |
Fetal response to maternal methadone administration.
Topics: Adult; Analgesics, Opioid; Female; Fetal Movement; Fetus; Heart Rate, Fetal; Humans; Male; Methadone | 2005 |
Fetal response to maternal methadone administration.
Topics: Adult; Analgesics, Opioid; Female; Fetal Movement; Fetus; Heart Rate, Fetal; Humans; Male; Methadone | 2005 |
Fetal response to maternal methadone administration.
Topics: Adult; Analgesics, Opioid; Female; Fetal Movement; Fetus; Heart Rate, Fetal; Humans; Male; Methadone | 2005 |
Fetal response to maternal methadone administration.
Topics: Adult; Analgesics, Opioid; Female; Fetal Movement; Fetus; Heart Rate, Fetal; Humans; Male; Methadone | 2005 |
Pregnancy outcome in women who use opiates.
Topics: Adult; England; Female; Heroin; Humans; Infant, Newborn; Male; Medical Records; Methadone; Neonatal | 2006 |
Prospective multicenter observational study of 260 infants born to 259 opiate-dependent mothers on methadone or high-dose buprenophine substitution.
Topics: Adult; Buprenorphine; Female; HIV Seropositivity; Humans; Infant Care; Infant, Newborn; Methadone; N | 2006 |
Changes to methadone clearance during pregnancy.
Topics: Adolescent; Adult; Area Under Curve; Chromatography, High Pressure Liquid; Female; Heroin; Heroin De | 2005 |
Effect of chronic maternal methadone therapy on intrapartum fetal heart rate patterns.
Topics: Adult; Cohort Studies; Ethnicity; Female; Gestational Age; Heart Rate, Fetal; Humans; Methadone; Opi | 2006 |
Gender differences and pregnant women in a methadone maintenance treatment (MMT) clinic.
Topics: Adult; Age Factors; Cocaine-Related Disorders; Cohort Studies; Comorbidity; Emigration and Immigrati | 2006 |
The effect of maternal methadone use on the fetal heart pattern: a computerised CTG analysis.
Topics: Adult; Cardiotocography; Diagnosis, Computer-Assisted; Female; Heart Rate, Fetal; Humans; Methadone; | 2006 |
Substance abuse in pregnancy: opioid substitution in a northern Ireland maternity unit.
Topics: Adult; Buprenorphine; Codeine; Female; Heroin Dependence; Humans; Infant, Newborn; Maternal-Fetal Ex | 2006 |
Methadone in pregnancy: treatment retention and neonatal outcomes.
Topics: Adult; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Small for Gestational Age; Methad | 2007 |
Intrapartum and postpartum analgesia for women maintained on methadone during pregnancy.
Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Case-Control Studies; Cesarean | 2007 |
Using population data to examine the prevalence and correlates of neonatal abstinence syndrome.
Topics: Adult; Cross-Sectional Studies; Databases, Factual; Female; Gravidity; Humans; Infant, Newborn; Inte | 2007 |
Rooming-in compared with standard care for newborns of mothers using methadone or heroin.
Topics: Adult; Breast Feeding; British Columbia; Child Custody; Cohort Studies; Comorbidity; Female; Heroin; | 2007 |
[The effect of substitution therapy on the birth weight of the newborn, its postpartum adaptation, trophic and course of the neonatal abstinence syndrome].
Topics: Apgar Score; Birth Weight; Buprenorphine; Female; Fetal Growth Retardation; Heroin Dependence; Human | 2007 |
Outcomes of neonates conceived on methadone maintenance therapy.
Topics: Adult; Analgesics, Opioid; Birth Weight; Female; Follow-Up Studies; Gestational Age; Humans; Infant, | 2008 |
Buprenorphine and methadone treatment of opiate dependence during pregnancy: comparison of fetal growth and neonatal outcomes in two consecutive case series.
Topics: Birth Weight; Buprenorphine; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Infant Mor | 2008 |
Methadone maintenance and breastfeeding in the neonatal period.
Topics: Bottle Feeding; Breast Feeding; Dose-Response Relationship, Drug; Drug Administration Schedule; Fema | 2008 |
Follow-up of methadone-treated and untreated narcotic-dependent women and their infants: health, developmental, and social implications.
Topics: Adult; Developmental Disabilities; Female; Follow-Up Studies; Health Status; Humans; Infant; Infant, | 1981 |
Motoric and attentional behavior in infants of methadone-maintained women.
Topics: Aging; Attention; Behavior; Female; Humans; Infant; Male; Methadone; Motor Activity; Opioid-Related | 1983 |
Perinatal addiction: the effects of maternal narcotic and nonnarcotic substance abuse on the fetus and neonate.
Topics: Adult; Arousal; Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, D | 1984 |
Fetal breathing movements and the response to carbon dioxide in patients on methadone maintenance.
Topics: Carbon Dioxide; Female; Fetus; Humans; Methadone; Movement; Opioid-Related Disorders; Pregnancy; Pre | 1984 |
A longitudinal study of offspring born to methadone-maintained women. I. Design, methodology, and description of women's resources for functioning.
Topics: Adolescent; Adult; Child Behavior; Child Development; Cognition; Family; Female; Follow-Up Studies; | 1984 |
A longitudinal study of offspring born to methadone-maintained women. II. Dyadic interaction and infant behavior at 4 months.
Topics: Child Behavior; Child Development; Cognition; Communication; Female; Follow-Up Studies; Heroin Depen | 1984 |
A longitudinal study of offspring born to methadone-maintained women. III. Effects of multiple risk factors on development at 4, 8, and 12 months.
Topics: Attention; Child Behavior; Child Development; Female; Follow-Up Studies; Heroin Dependence; Humans; | 1984 |
Drug addiction during pregnancy.
Topics: Birth Weight; Delivery, Obstetric; Female; Fetal Monitoring; Follow-Up Studies; Heroin; Heroin Depen | 1983 |
A comprehensive care program for pregnant addicts: obstetrical, neonatal, and child development outcomes.
Topics: Adult; Birth Weight; Child Development; Counseling; Delivery, Obstetric; Female; Gestational Age; He | 1984 |
The emergence of maternal drug addiction as a problem in Ireland 1981.
Topics: Adolescent; Adult; Cesarean Section; Female; Heroin; Humans; Infant, Newborn; Ireland; Male; Materna | 1983 |
Fetal and postnatal growth of children born to narcotic-dependent women.
Topics: Body Height; Female; Fetus; Growth; Heroin Dependence; Humans; Infant, Newborn; Longitudinal Studies | 1983 |
[Condition of 89 newborn infants of drug-addicted mothers].
Topics: Abnormalities, Drug-Induced; Adult; Apgar Score; Female; Heroin Dependence; Humans; Infant, Low Birt | 1983 |
Investigation of 89 children born by drug-dependent mothers. I. Neonatal course.
Topics: Adult; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Infant, Small | 1983 |
Investigation of 89 children born by drug-dependent mothers. II. Follow-up 1-10 years after birth.
Topics: Adult; Child; Child Behavior Disorders; Child, Institutionalized; Child, Preschool; Female; Follow-U | 1983 |
Duration of thrombocytosis in infants of polydrug (including methadone) users.
Topics: Female; Humans; Infant; Infant, Newborn; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy C | 1982 |
Polydrug- and methadone-addicted newborns: a continuum of impairment?
Topics: Abnormalities, Drug-Induced; Birth Weight; Child Behavior; Female; Heroin Dependence; Humans; Infant | 1982 |
[Pregnancy in heroin addiction; an 11-year survey at the Wilhelmina Gasthuis in Amsterdam].
Topics: Female; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Infant, Premature; Infant, Sma | 1982 |
Respiratory and hemodynamic effects of methadone in pregnant women.
Topics: Blood Pressure; Female; Heroin Dependence; Humans; Mathematics; Methadone; Oxygen Consumption; Physi | 1980 |
Heroin addiction and pregnancy.
Topics: Animals; Female; Fetal Diseases; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseas | 1981 |
[Jaundice in the newborn infant of a "poly-drug-dependent" mother. Heroin and methadone, G6PDH deficiency and antagonism in the enzymatic modulation].
Topics: Adult; Drug Antagonism; Female; Glucosephosphate Dehydrogenase Deficiency; Heroin Dependence; Humans | 1980 |
Developmental outcomes of children of mothers dependent on heroin or heroin/methadone during pregnancy.
Topics: Child; Child of Impaired Parents; Child, Preschool; Cross-Sectional Studies; Developmental Disabilit | 1994 |
Development after prenatal exposure to cocaine, heroin and methadone.
Topics: Case-Control Studies; Child; Child of Impaired Parents; Child, Preschool; Cocaine; Developmental Dis | 1994 |
Decreased maternal-fetal attachment in methadone-maintained pregnant women: a preliminary study.
Topics: Adolescent; Adult; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Methadone; Mother- | 1995 |
[Withdrawal syndrome in a newborn infant born to an addicted mother receiving methadone].
Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Male; Methadone; Neonatal Abstinence Synd | 1995 |
Methadone maintenance treatment. Pregnant women taking methadone should be warned about withdrawal symptoms in babies.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Patient | 1995 |
Cognitive development at preschool-age of infants of drug-dependent mothers.
Topics: Child, Preschool; Cocaine; Cognition; Female; Heroin; Humans; Infant; Infant, Newborn; Language; Mal | 1994 |
Methadone therapy.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Pregnan | 1993 |
A comparison of meconium, maternal urine and neonatal urine for detection of maternal drug use during pregnancy.
Topics: Adult; Cocaine; Dronabinol; Female; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Imm | 1994 |
Study of 45 pregnant opiate addicts in Dublin.
Topics: Adult; Child Welfare; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Ireland; Life Styl | 1993 |
[The consequences for the child of drug addiction in the mother: current status in relation to knowledge and management policy in The Netherlands].
Topics: Child Development; Child, Preschool; Female; Humans; Infant; Infant Care; Infant, Newborn; Methadone | 1993 |
[Neonatal abstinence syndrome: current and future aspects].
Topics: Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Opium; Parasympatholytics; | 1993 |
Relationship between maternal methadone dosage, maternal-neonatal methadone levels, and neonatal withdrawal.
Topics: Female; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; Pregnancy; Pregnancy Compl | 1993 |
Methadone use during pregnancy.
Topics: Animals; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinence Syndrome; Pregna | 1995 |
Effect of methadone on the biophysical profile.
Topics: Adult; Circadian Rhythm; Female; Fetal Movement; Heart Rate, Fetal; Humans; Methadone; Opioid-Relate | 1996 |
[Pregnancy and drug dependence].
Topics: Administration, Oral; Adult; Austria; Delayed-Action Preparations; Dose-Response Relationship, Drug; | 1996 |
Infants born to narcotic dependent mothers: physical growth patterns in the first 12 months of life.
Topics: Adult; Cohort Studies; Female; Fetal Growth Retardation; Growth; Humans; Infant; Infant, Newborn; Me | 1997 |
Effectiveness of CME workshops for alcohol and other drug-related interventions in general practice.
Topics: Accreditation; Alcoholism; Australia; Education, Medical, Continuing; Family Practice; Female; Human | 1998 |
Methadone maintenance in pregnancy: a reappraisal.
Topics: Adult; Cocaine; Female; Fetus; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Com | 1998 |
In contrast to cocaine, prenatal exposure to methadone does not produce detectable alterations in the developing mouse brain.
Topics: Aging; Animals; Animals, Newborn; Astrocytes; Brain; Cerebral Cortex; Cocaine; Cocaine-Related Disor | 1998 |
Opioid detoxification in pregnancy.
Topics: Adult; Analgesics; Analgesics, Opioid; Chi-Square Distribution; Clonidine; Drug Therapy, Combination | 1998 |
Maternal use of heroin and methadone and infant birth weight.
Topics: Birth Weight; Female; Heroin Dependence; Humans; Methadone; Narcotics; Pregnancy; Pregnancy Complica | 1998 |
[Pregnancy, abortion and delivery in a cohort of heroin dependent patients treated with drug substitution (methadone and buprenorphine) in Aquitaine].
Topics: Abortion, Legal; Adult; Buprenorphine; Cohort Studies; Female; France; Heroin Dependence; Humans; Me | 1999 |
Outcome predictors in pregnant opiate and polydrug users.
Topics: Benzodiazepines; Birth Weight; Female; Humans; Infant, Low Birth Weight; Infant, Newborn; Methadone; | 1999 |
Alterations in methadone metabolism during late pregnancy.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Half-Life; Humans; Me | 1999 |
Use of methadone.
Topics: Analgesics, Opioid; Drug Interactions; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonat | 2000 |
The drug epidemic: effects on newborn infants and health resource consumption at a tertiary perinatal centre.
Topics: Adult; Ambulatory Care Facilities; Amphetamines; Australia; Benzodiazepines; Cannabis; Cocaine; Como | 2000 |
[Methadone treatment during pregnancy and its effect on the child. Better than continuing drug abuse, should be monitored by a specialized antenatal care center].
Topics: Adult; Embryonic and Fetal Development; Female; Heroin Dependence; Humans; Infant, Newborn; Maternal | 2000 |
[Drug dependence in pregnancy. Better to substitute than complete withdrawal].
Topics: Analgesics, Opioid; Buprenorphine; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Ne | 2000 |
[The first pregnancy and delivery within the framework of the methadone program in the Czech Republic].
Topics: Adult; Czech Republic; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Pregnancy; Pre | 2000 |
Treatment of opioid dependence in pregnant women.
Topics: Adult; Female; HIV Infections; Humans; Infant, Newborn; Life Style; Methadone; Narcotics; Neonatal A | 2000 |
[Neonatal withdrawal syndrome in twins born to a mother on methadone substitution].
Topics: Adult; Diseases in Twins; Female; Follow-Up Studies; Heroin Dependence; Humans; Infant, Newborn; Met | 2000 |
Mothers and methadone.
Topics: Analgesics, Opioid; Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Neonatal Abstinen | 2000 |
[Opiate dependent pregnant patients and mothers. What must be regarded in drug substitution and detoxification].
Topics: Ambulatory Care; Female; Germany; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; | 2001 |
Coordinated outpatient care of the narcotic-dependent infant.
Topics: Ambulatory Care; Child Health Services; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; | 2001 |
Methadone and the pregnant user: a matter for careful clinical consideration.
Topics: Female; Heroin Dependence; Humans; Maternal Health Services; Methadone; Pregnancy; Pregnancy Complic | 2001 |
Methadone dependence and its effects on consecutive pregnancies.
Topics: Adolescent; Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Fetal Growth Retardation; | 2000 |
Pharmacotherapy of narcotic dependence.
Topics: Buprenorphine; Cyclazocine; Dextropropoxyphene; Diphenoxylate; Female; Humans; Infant, Newborn; Infa | 1977 |
Drug addiction in pregnancy.
Topics: Adult; Female; Follow-Up Studies; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newbor | 1976 |
Overview: protracted effects of early exposure to drugs of abuse.
Topics: Animals; Female; Growth; Haplorhini; Heroin Dependence; Humans; Methadone; Opioid-Related Disorders; | 1979 |
Palmar crease variants and their clinical significance: a study of newborns at risk.
Topics: Adult; Age Factors; Child; Child, Preschool; Dermatoglyphics; Down Syndrome; Female; Fetus; Hand; Hu | 1977 |
Management of pregnant drug-dependent women.
Topics: Family Therapy; Female; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant | 1978 |
Perinatal addiction: outcome and management.
Topics: Abruptio Placentae; Apgar Score; Breech Presentation; Cesarean Section; Counseling; Female; Fetal Gr | 1977 |
[The effect of heroin and methadone on pregnancy and the newborn infant].
Topics: Female; Fetus; Heroin; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Labor, | 1979 |
Sudden unexpected death in infants of narcotic-dependent mothers.
Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Male; Maternal-Fetal | 1978 |
Commonly asked clinical questions about methadone maintenance.
Topics: Age Factors; Antidepressive Agents; Community Mental Health Services; Comprehensive Health Care; Fac | 1977 |
Narcotic abuse in pregnancy.
Topics: Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pre | 1979 |
The narcotic-dependent mother: fetal and neonatal consequences.
Topics: Adult; Female; Fetal Death; Fetus; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; Inf | 1977 |
Problems pertaining to the care of newborn infants of drug-addicted women.
Topics: Apnea; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Narcotics; P | 1978 |
Psychosocial care of the pregnant narcotic addict.
Topics: Behavior Therapy; Female; Heroin Dependence; Humans; Infant, Low Birth Weight; Infant, Newborn; Infa | 1978 |
Chromosome aberrations in the mother and the newborn from drug-addiction pregnancies.
Topics: Blood Cells; Chromatids; Chromosome Aberrations; Female; Heroin Dependence; Humans; Infant, Newborn; | 1978 |
Methadone.
Topics: Female; Humans; Methadone; Pregnancy; Pregnancy Complications; Substance-Related Disorders | 1978 |
Methadone.
Topics: Female; Heroin Dependence; Humans; Methadone; Pregnancy; Pregnancy Complications | 1978 |
Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Child, Preschool; Female; Follow-Up Studies; Heroin De | 1976 |
Differential effects of maternal heroin and methadone use on birthweight.
Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Ethnicity; Female; Gestational Age; Heroin; H | 1976 |
Neonatal drug dependence: developmental and bio-cultural considerations.
Topics: Birth Weight; Family Characteristics; Female; Fetus; Humans; Infant Mortality; Infant, Newborn; Infa | 1976 |
Urinary amine alterations in drug-addiction pregnancy.
Topics: Adolescent; Adult; Epinephrine; Female; Heroin; Humans; Methadone; Norepinephrine; Pregnancy; Pregna | 1976 |
Heroin addiction, methadone maintenance, and pregnancy.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Nutritional Physiological Phenomena; | 1976 |
Results of 313 consecutive live births of infants delivered to patients in the New York City Methadone Maintenance Treatment Program.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Drug and Narcotic Control; Female; Fetus; Follow-Up St | 1975 |
Methadone assays in pregnant women and progeny.
Topics: Amniotic Fluid; Chromatography, Gas; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infa | 1975 |
Observations on methadone withdrawal in 16 neonates.
Topics: Adolescent; Adult; Birth Weight; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn | 1975 |
Fetal stress from methadone withdrawal.
Topics: Adrenal Glands; Amniocentesis; Amniotic Fluid; Epinephrine; Female; Fetus; Heroin Dependence; Humans | 1975 |
Multiple births in drug-addicted women.
Topics: Adult; Female; Heroin; Heroin Dependence; Humans; Infant, Newborn; Male; Methadone; Ovulation; Pregn | 1975 |
Acute management of neonatal addiction.
Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant | 1975 |
Disposition of methadone and its relationship to severity of withdrawal in the newborn.
Topics: Administration, Oral; Chromatography, Gas; Dose-Response Relationship, Drug; Female; Fetal Blood; Ha | 1975 |
A study of factors that influence the severity of neonatal narcotic withdrawal.
Topics: Administration, Oral; Bilirubin; Birth Weight; Body Weight; Dose-Response Relationship, Drug; Enviro | 1975 |
Current concepts in the management of the pregnant opiate addict.
Topics: Administration, Oral; Anesthesia, Conduction; Anesthesia, Obstetrical; Birth Weight; Counseling; Fem | 1975 |
Neurological aspects of perinatal narcotic addiction and methadone treatment.
Topics: Auditory Perception; Autonomic Nervous System; Birth Weight; Central Nervous System Diseases; Child | 1975 |
Part II. Behavioral and electrophysiological characteristics of the addicted neonate.
Topics: Acoustic Stimulation; Arousal; Attention; Birth Weight; Electrophysiology; Evoked Potentials; Female | 1975 |
Neonatal addiction: a two-year study. Part I. Clinical and developmental characteristics of infants of mothers on methadone maintenance.
Topics: Administration, Oral; Age Factors; Attention; Birth Weight; Child Development; Diazepam; Dose-Respon | 1975 |
Somatic growth effects of perinatal addiction.
Topics: Birth Weight; Cephalometry; Child; Child Development; Child Nutritional Physiological Phenomena; Chi | 1975 |
Differential effects of heroin and methadone on birth weights.
Topics: Birth Weight; Dose-Response Relationship, Drug; Female; Fetus; Gestational Age; Heroin Dependence; H | 1975 |
Cytogenetic risks to the offspring of pregnant addicts.
Topics: Chromosome Aberrations; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Karyotyping; Male | 1975 |
Heat-stable alkaline phosphatase in methadone-maintained pregnancies.
Topics: Administration, Oral; Alkaline Phosphatase; Female; Fetal Blood; Gestational Age; Heroin Dependence; | 1975 |
Clinical observations on methadone-maintained pregnancies.
Topics: Administration, Oral; Adult; Birth Weight; Counseling; Dose-Response Relationship, Drug; Female; Fet | 1975 |
Narcotic addiction in the newborn: differences in behavior generated by methadone and heroin.
Topics: Adaptation, Physiological; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New | 1975 |
Neonatal narcotic abstinence: Effects of pharmacotherapeutic agents and maternal drug usage on nutritive sucking behavior.
Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Opium; Phenob | 1976 |
A study of factors that influence the severity of neonatal narcotic withdrawal.
Topics: Apgar Score; Female; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lighting; | 1976 |
Cytogenetics of methadone-managed and heroin-addicted pregnant women and their newborn infants.
Topics: Adolescent; Adult; Apgar Score; Chromosome Aberrations; Female; Fetal Blood; Heroin Dependence; Huma | 1976 |
Drug addiction in pregnancy and the neonate.
Topics: Alcoholic Intoxication; Birth Weight; Diazepam; Female; Heroin Dependence; Hospitalization; Humans; | 1976 |
Pharmacologic observations on the neonatal withdrawal syndrome.
Topics: Female; Half-Life; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kinetics; | 1976 |
Narcotic addiction in pregnancy with adverse maternal and perinatal outcome.
Topics: Adult; Female; Fetal Growth Retardation; Heroin Dependence; Hong Kong; Humans; Infant, Low Birth Wei | 1992 |
Improving treatment outcome in pregnant opiate-dependent women.
Topics: Adult; Combined Modality Therapy; Female; Fetal Growth Retardation; Follow-Up Studies; Heroin; Heroi | 1992 |
[Heroin abuse and methadone substitution in pregnancy].
Topics: Asphyxia Neonatorum; Cardiotocography; Dose-Response Relationship, Drug; Female; Fetal Growth Retard | 1992 |
[Drug substitution and withdrawal in pregnancy. Indication, side effects, acute status, monitoring and results].
Topics: Contraindications; Counseling; Drug Overdose; Female; Heroin Dependence; Humans; Infant, Newborn; Me | 1991 |
[Jurisprudence aspects of drug substitution and withdrawal in pregnancy].
Topics: Female; Germany; Humans; Infant, Newborn; Jurisprudence; Methadone; Neonatal Abstinence Syndrome; Pr | 1991 |
A comparison of the effects of single- and split-dose methadone administration on the fetus: ultrasound evaluation.
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fetal Movement; Humans; Infa | 1991 |
Narcotic addiction: the expectant mother and her baby.
Topics: Adolescent; Adult; Diseases in Twins; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Pr | 1990 |
Report of the Expert Advisory Committee on the Use of Drugs in the Treatment of Abuse and Dependence to Narcotic and Controlled Drugs.
Topics: Canada; Drug and Narcotic Control; Female; Humans; Inactivation, Metabolic; Methadone; Opioid-Relate | 1990 |
Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate.
Topics: Adult; Diazepam; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Infant, Newborn, Diseas | 1990 |
Patterns of multiple substance abuse during pregnancy: implications for mother and fetus.
Topics: Adolescent; Adult; Age Factors; Alcoholism; Cocaine; Female; Fetal Diseases; Heroin; Humans; Marijua | 1990 |
Drug-addicted mothers, their infants, and SIDS.
Topics: Adult; Alcohol Drinking; Cocaine; Developmental Disabilities; Female; Heroin Dependence; Humans; Inf | 1988 |
Neonatal behavior after drug dependent pregnancy.
Topics: Child; Child Behavior; Child, Preschool; Developmental Disabilities; Electroencephalography; Female; | 1989 |
Altered methadone pharmacokinetics in pregnancy: implications for dosing.
Topics: Adult; Computer Simulation; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; | 1989 |
Kinin-kininase system in drug addict woman in pregnancy and puerperium.
Topics: Carboxypeptidases; Female; Humans; Kallikreins; Lysine Carboxypeptidase; Methadone; Peptidyl-Dipepti | 1989 |
Kallikrein-kinin system in newborns of the drug addicted.
Topics: Aging; Carboxypeptidases; Female; Humans; Infant, Newborn; Kallikreins; Lysine Carboxypeptidase; Mal | 1989 |
Outpatient methadone programme for pregnant heroin using women.
Topics: Adult; Ambulatory Care; Evaluation Studies as Topic; Female; Heroin Dependence; Humans; Methadone; N | 1989 |
[Proposal of a detoxication program for drug dependency in pregnancy].
Topics: Female; Humans; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complications | 1989 |
Prenatal cocaine exposure is associated with respiratory pattern abnormalities.
Topics: Apnea; Cheyne-Stokes Respiration; Cocaine; Female; Humans; Infant, Newborn; Methadone; Pregnancy; Pr | 1989 |
Clinical studies of infants and children exposed prenatally to heroin.
Topics: Child Behavior; Child Development; Child, Preschool; Cognition; Female; Heroin Dependence; Humans; I | 1989 |
The effects of methadone treatment on the reactivity of the nonstress test.
Topics: Female; Fetal Movement; Heart Rate, Fetal; Humans; Methadone; Opioid-Related Disorders; Pregnancy; P | 1989 |
Methadone maintenance in pregnancy: consequences to care and outcome.
Topics: Female; Humans; Methadone; Pregnancy; Pregnancy Complications; Substance-Related Disorders | 1989 |
Prospective study of human immunodeficiency virus infection and pregnancy outcomes in intravenous drug users.
Topics: Adult; Female; HIV Seropositivity; Hospitalization; Humans; Injections, Intravenous; Methadone; New | 1989 |
Behaviour in first year after drug dependent pregnancy.
Topics: Child Behavior; Child Development; Electroencephalography; Female; Humans; Illicit Drugs; Infant; In | 1989 |
Reduced estriol and dehydroepiandrosterone sulphate plasma levels in methadone-addicted pregnant women.
Topics: Adult; Circadian Rhythm; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estriol; Female; Ge | 1986 |
Effects of cocaine on pregnancy outcome.
Topics: Abortion, Spontaneous; Adult; Birth Weight; Body Height; Female; Humans; Infant, Newborn; Maternal-F | 1986 |
Inhaling heroin during pregnancy.
Topics: Female; Heroin Dependence; Humans; Methadone; Pregnancy; Pregnancy Complications | 1988 |
Inhaling heroin during pregnancy.
Topics: Female; Heroin; Heroin Dependence; Humans; Infant, Newborn; Methadone; Neonatal Abstinence Syndrome; | 1988 |
The use of tricyclic antidepressants in methadone maintained pregnant women and infant outcome.
Topics: Adult; Antidepressive Agents, Tricyclic; Apgar Score; Birth Weight; Demography; Female; Heroin Depen | 1988 |
[Effects of maternal methadone addiction on the growth and health of the fetus].
Topics: Embryonic and Fetal Development; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone | 1988 |
A review of the characteristics and treatment progress of 45 pregnant opiate addicts attending the Irish National Drug Advisory and Treatment Centre over a two year period.
Topics: Adolescent; Adult; Female; Humans; Infant, Newborn; Ireland; Methadone; Narcotics; Pregnancy; Pregna | 1988 |
Group psychotherapy with methadone-maintained pregnant women.
Topics: Adult; Attitude of Health Personnel; Female; Humans; Methadone; Opioid-Related Disorders; Patient Ed | 1988 |
Methadone maintenance in pregnancy: consequences to care and outcome.
Topics: Adult; Alcohol Drinking; Drug Evaluation, Preclinical; Female; Hematocrit; Humans; Methadone; Pregna | 1988 |
Maternal drug therapy: effect on fetal and neonatal growth and neurobehavior.
Topics: Aminopterin; Amphetamines; Animals; Anticoagulants; Anticonvulsants; Antihypertensive Agents; Birth | 1986 |
Pregnancy in a drug-abusing population.
Topics: Adult; Female; Gestational Age; Humans; Infant, Newborn; Methadone; Pregnancy; Pregnancy Complicatio | 1986 |
Heroin addiction in pregnancy.
Topics: Female; Heroin Dependence; Humans; Methadone; Midwifery; Pregnancy; Pregnancy Complications | 1986 |
Management of narcotic dependent pregnancy.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Methadone; Narcotics; Opioid-Related Disorders; | 1986 |
Perinatal cocaine and methamphetamine exposure: maternal and neonatal correlates.
Topics: Apgar Score; Birth Weight; Child Behavior; Cocaine; Female; Fetal Growth Retardation; Gestational Ag | 1987 |
Impact of maternal drug dependency on birth weight and head circumference of offspring.
Topics: Adult; Birth Weight; Female; Fetal Growth Retardation; Fetus; Head; Humans; Infant, Newborn; Methado | 1987 |
Maternal narcotic addiction: pregnancy outcome in patients managed by a specialized drug-dependency antenatal clinic.
Topics: Adolescent; Adult; Female; Fetal Death; Health Facilities; Heroin Dependence; Humans; Infant, Newbor | 1987 |
Methadone in pregnancy: clinical-toxicological aspects.
Topics: Female; Humans; Infant, Newborn; Methadone; Opioid-Related Disorders; Pregnancy; Pregnancy Complicat | 1986 |
Abnormal sleeping ventilatory pattern in infants of substance-abusing mothers.
Topics: Age Factors; Cocaine; Female; Heart Rate; Heroin; Humans; Infant; Male; Methadone; Narcotics; Phency | 1986 |
[Substance dependence and pregnancy. Experience in care].
Topics: Adult; Female; Fetal Growth Retardation; Heroin; Heroin Dependence; Humans; Methadone; Pregnancy; Pr | 1986 |
Occurrence of strabismus in infants born to drug-dependent women.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Male; Methadone; Pregnancy; Pregnancy Complicati | 1987 |
Long-term effects of prenatal methadone maintenance.
Topics: Adult; Age Factors; Child; Child Behavior; Child Development; Child, Preschool; Female; Fetus; Follo | 1985 |
Altered methadone pharmacokinetics in methadone-maintained pregnant women.
Topics: Adult; Female; Humans; Metabolic Clearance Rate; Methadone; Milk, Human; Pregnancy; Pregnancy Compli | 1985 |
Cocaine use in pregnancy.
Topics: Abortion, Spontaneous; Adult; Cocaine; Female; Fetus; Humans; Infant, Newborn; Methadone; Obstetric | 1985 |
When the client is pregnant: information for counselors.
Topics: Adult; Attitude of Health Personnel; Breast Feeding; Family Planning Services; Female; Guilt; Heroin | 1985 |
Estriol excretion profiles in narcotic-addicted pregnant women.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Age Fact | 1972 |
Infant of the addicted mother.
Topics: Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Disea | 1973 |
The effect of a methadone treatment program upon pregnant heroin addicts and their newborn infants.
Topics: Adult; Birth Weight; Blood Glucose; Calcium; Female; Fetus; Gestational Age; Heroin Dependence; Huma | 1974 |
Methadone maintenance during pregnancy: pregnancy, birth, and neonate characteristics.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Gestational Age; Heroin Dependence; Humans; In | 1974 |
Analyses of methadone and other drugs in maternal and neonatal body fluids: use in evaluation of symptoms in a neonate of mother maintained on methadone.
Topics: Adult; Amniotic Fluid; Body Fluids; Escherichia coli Infections; Female; Fetal Blood; Heroin Depende | 1974 |
Guidelines for the withdrawal of narcotic and general depressant drugs.
Topics: Barbiturates; Dose-Response Relationship, Drug; Drug Tolerance; Female; Heroin; Humans; Hypnotics an | 1973 |
Methadone maintenance, pregnancy, and progeny.
Topics: Administration, Oral; Adult; Apgar Score; Birth Weight; Female; Fetal Death; Heroin; Heroin Dependen | 1973 |
[Psychiatric emergencies during pregnancy and in the puerperium].
Topics: Amphetamine; Cannabis; Emergencies; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lyse | 1973 |
A model for drug abuse treatment program evaluation.
Topics: Adult; Black or African American; Community Health Services; Counseling; Educational Status; Evaluat | 1973 |
Methadone maintenance during pregnancy.
Topics: Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Pregnancy; | 1973 |
Results of 120 deliveries of patients in the New York City methadone maintenance treatment program.
Topics: Adolescent; Adult; Birth Weight; Delivery, Obstetric; Demography; Ethnicity; Female; Heroin Dependen | 1973 |
Observations on the sudden death of infants born to addicted mothers.
Topics: Adult; Death, Sudden; Female; Heroin Dependence; Humans; Infant; Infant Mortality; Infant, Newborn; | 1973 |
The effect of a methadone treatment program upon pregnant addicts and their infants.
Topics: Adult; Apgar Score; Female; Hepatitis; Heroin Dependence; Humans; Infant Mortality; Infant, Newborn; | 1973 |
Clinical evaluation of pregnant methadone maintenance patients and their newborn infants.
Topics: Adolescent; Adult; Community Health Services; Evaluation Studies as Topic; Female; Heroin Dependence | 1973 |
Treatment experiences with the pregnant addict.
Topics: Adolescent; Adult; Amniotic Fluid; Female; Gestational Age; Hepatitis; Heroin Dependence; Humans; In | 1973 |
Neonatal effects of heroin addiction and methadone-treated pregnancies. Preliminary report on 70 live births.
Topics: Adult; Birth Weight; Dose-Response Relationship, Drug; Female; Heroin Dependence; Humans; Infant, Ne | 1973 |
Pregnancy in the context of narcotic addiction and methadone maintenance.
Topics: Adult; Alcoholism; Barbiturates; Chicago; Female; Heroin Dependence; Humans; Infant Mortality; Infan | 1973 |
L0w dose methadone to abstinence in a maternity-family care program.
Topics: Adult; Family Therapy; Female; Heroin Dependence; Humans; Male; Methadone; Pregnancy; Pregnancy Comp | 1973 |
A preliminary (8-month) report on a low-dose methadone-to-abstinence family care program at Kings County Addicitve Disease Hospital.
Topics: Adolescent; Adult; Community Health Services; Counseling; Female; Heroin Dependence; Humans; Male; M | 1973 |
Methadone effects on pregnancy and the newborn.
Topics: Adolescent; Adult; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Ma | 1973 |
Late presentation of drug withdrawal symptoms in newborns.
Topics: Birth Weight; Camphor; Diazepam; Female; Gestational Age; Heroin Dependence; Humans; Infant; Infant, | 1974 |
Content of amniotic fluid prostaglandins in normal, diabetic, and drug-abuse human pregnancy.
Topics: Amniotic Fluid; Female; Heroin Dependence; Humans; Labor, Obstetric; Methadone; Pregnancy; Pregnancy | 1974 |
Narcotic withdrawal in the newborn infant.
Topics: Diazepam; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mate | 1974 |
Evaluation of a latex agglutination-inhibition slide pregnancy test (Pregnosis).
Topics: Abortion, Spontaneous; Adolescent; Adult; Antidepressive Agents; Chorionic Gonadotropin; Codeine; Co | 1974 |
Born with a habit. Infants of drug-addicted mothers.
Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Barbiturates; Camphor; Chlorpromazine; Codeine; Dia | 1974 |
Studies of human amniotic fluid phospholipids in normal, diabetic, and drug-abuse pregnancy.
Topics: Amniotic Fluid; Chromatography, Gas; Chromatography, Thin Layer; Densitometry; Fatty Acids; Female; | 1974 |
Heroin addiction during pregnancy.
Topics: Adolescent; Adult; Amniocentesis; Bilirubin; Birth Weight; Female; Gestational Age; Heroin; Humans; | 1972 |
Methadone withdrawal in newborn infants.
Topics: Female; Gestational Age; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal- | 1972 |
Treatment of a pregnant opiate addict with oral methadone.
Topics: Administration, Oral; Adult; Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Met | 1972 |
Drug addiction in pregnancy. An obstetrician's experience.
Topics: Abortion, Induced; Abortion, Spontaneous; Amenorrhea; Anesthesia, Obstetrical; Female; Humans; Infan | 1972 |
Observations on heroin and methadone withdrawal in the newborn.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Heroin; Humans; Infant, Newborn; Infant, Newbo | 1971 |
Fertility of narcotics addicts and effects of addiction on the offspring.
Topics: Female; Fertility; Heroin; Humans; Infant, Newborn; Maternal-Fetal Exchange; Methadone; Morphine Dep | 1971 |
Neonatal biliary tract infection coincident with maternal methadone therapy.
Topics: Adult; Cholangitis; Cholecystitis; Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Disease | 1971 |
Narcotics and medical practice. Medical use of morphine and morphine-like drugs and management of persons dependent on them.
Topics: American Medical Association; Female; Health Education; Heroin; Humans; Legislation, Drug; Methadone | 1971 |
Pregnancy in narcotics addicts treated by medical withdrawal. The methadone detoxification program.
Topics: Adolescent; Adult; Birth Weight; Female; Heroin; Humans; Infant, Newborn; Labor Presentation; Methad | 1969 |
Menstrual function and pregnancy in narcotics addicts treated with methadone.
Topics: Abortion, Spontaneous; Adult; Amenorrhea; Female; Fetal Death; Humans; Infant, Newborn; Menstruation | 1968 |