methadone has been researched along with Coma in 16 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute respiratory distress syndrome (ARDS) due to methadone (MTD) toxicity is a known but rather uncommon phenomenon." | 7.79 | Acute respiratory distress syndrome caused by methadone syrup. ( Aghabiklooei, A; Hassanian-Moghaddam, H; Shadnia, S; Zamani, N, 2013) |
| " Acute poisoning occurred after taking 100 ml of 1,4-butanediol together with phenyl-2- (1-pyrrolidinyl) -1-pentanone and 2 g of methadone, clinically manifested in the form of convulsive syndrome, depression of consciousness to the level of coma 3, edema and swelling brain, acute respiratory failure, mixed decompensated respiratory and metabolic lactic acidosis (pH 7." | 4.12 | [CLINICAL CASE OF ACUTE SEVERE COMBINED POISONING WITH NARCOTIC SUBSTANCES OF DEPENDENT AND PSYCHOSTIMULATING EFFECTS]. ( Antonova, A; Batotsyrenov, B; Kovalenko, A; Lodyagin, A; Loladze, A; Sinenchenko, A, 2022) |
| "Acute respiratory distress syndrome (ARDS) due to methadone (MTD) toxicity is a known but rather uncommon phenomenon." | 3.79 | Acute respiratory distress syndrome caused by methadone syrup. ( Aghabiklooei, A; Hassanian-Moghaddam, H; Shadnia, S; Zamani, N, 2013) |
| "We report on the preclinical management of a 4-year-old child who was found in a comatose condition with respiratory failure after accidental ingestion of methadone." | 3.72 | [Preclinical management of accidental methadone intoxication of a 4-year-old girl. Antagonist or intubation?]. ( Bernhard, M; Gries, A; Hainer, C, 2004) |
| " On reduction of opioid dosage he had visual and auditory hallucinations and showed deterioration of consciousness progressing to coma." | 1.27 | Unusual opioid withdrawal syndrome. A case-report. ( Grochow, LB; Hausheer, F; Kumor, KM, 1987) |
| "In cases associated with coma, the pathophysiology is secondary to local pressure necrosis caused by compression from the patient's own body." | 1.26 | Rhabdomyolysis secondary to drug overdose and prolonged coma. ( Chaikin, HL, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (43.75) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Sinenchenko, A | 1 |
| Lodyagin, A | 1 |
| Loladze, A | 1 |
| Batotsyrenov, B | 1 |
| Antonova, A | 1 |
| Kovalenko, A | 1 |
| Hermansen, SK | 1 |
| Christoffersen, DJ | 1 |
| Mehrpour, O | 1 |
| Hoyte, C | 1 |
| Amirabadizadeh, A | 1 |
| Brent, J | 1 |
| Aghabiklooei, A | 1 |
| Shadnia, S | 1 |
| Hassanian-Moghaddam, H | 1 |
| Zamani, N | 1 |
| Martin, M | 1 |
| Daoudal, P | 1 |
| Bein, C | 1 |
| Bazzi, N | 1 |
| Bourscheid, D | 1 |
| Floriot, C | 1 |
| Hayashi, T | 1 |
| Schönfeld, C | 1 |
| Tsokos, M | 1 |
| Hantson, P | 1 |
| Vanbinst, R | 1 |
| Wallemacq, P | 1 |
| Hainer, C | 1 |
| Bernhard, M | 1 |
| Gries, A | 1 |
| van den Brink, RB | 1 |
| Wilmink, JM | 1 |
| Vreeken, J | 1 |
| Chaikin, HL | 1 |
| Froomes, PR | 1 |
| Haddad, J | 1 |
| Harding, D | 1 |
| Kumor, KM | 1 |
| Grochow, LB | 1 |
| Hausheer, F | 1 |
| Frand, UI | 1 |
| Shim, CS | 1 |
| Williams, MH | 1 |
| Kersh, ES | 1 |
| Penn, AS | 1 |
| Rowland, LP | 1 |
| Fraser, DW | 1 |
| Kjeldgaard, JM | 1 |
| Hahn, GW | 1 |
| Heckenlively, JR | 1 |
| Genton, E | 1 |
16 other studies available for methadone and Coma
| Article | Year |
|---|---|
[CLINICAL CASE OF ACUTE SEVERE COMBINED POISONING WITH NARCOTIC SUBSTANCES OF DEPENDENT AND PSYCHOSTIMULATING EFFECTS].
Topics: Adult; Coma; Cross Infection; Humans; Hypoxia; Lactic Acid; Methadone; Narcotics | 2022 |
Common opioids and stimulants in autopsy and DUID cases: A comparison of measured concentrations.
Topics: Amphetamine; Analgesics, Opioid; Autopsy; Central Nervous System Stimulants; Cocaine; Coma; Heroin; | 2022 |
Clinical characteristics and time trends of hospitalized methadone exposures in the United States based on the Toxicology Investigators Consortium (ToxIC) case registry: 2010-2017.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Child; Child, Preschool; Coma; Drug Overdose; Female; H | 2020 |
Acute respiratory distress syndrome caused by methadone syrup.
Topics: Administration, Oral; Adult; Coma; Drug Compounding; Drug Overdose; Female; Humans; Male; Methadone; | 2013 |
[Inhaled methadone-induced non cardiogenic pulmonary edema with Acute Respiratory Distress Syndrome].
Topics: Administration, Inhalation; Coma; Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pu | 2011 |
"Cobblestone" appearance of the ascending colon.
Topics: Adult; Alcoholism; Analgesics, Opioid; Benzodiazepines; Cause of Death; Colon; Coma; Crohn Disease; | 2013 |
Accidental methadone overdose in an opiate-naive elderly patient.
Topics: Aged; Coma; Critical Care; Drug Overdose; Female; Humans; Medication Errors; Methadone; Narcotics; P | 2003 |
[Preclinical management of accidental methadone intoxication of a 4-year-old girl. Antagonist or intubation?].
Topics: Analgesics, Opioid; Child, Preschool; Coma; Emergency Medical Services; Female; Humans; Intubation, | 2004 |
[The importance of an accurate preoperative anamnesis].
Topics: Coma; Diuretics; Drug Synergism; Humans; Kidney Tubules; Lithium; Male; Medical History Taking; Meth | 1982 |
Rhabdomyolysis secondary to drug overdose and prolonged coma.
Topics: Acute Kidney Injury; Adult; Coma; Humans; Hypocalcemia; Male; Mescaline; Methadone; Myoglobin; Myogl | 1980 |
Coma, myalagia and hypoxia.
Topics: Adult; Coma; Humans; Male; Methadone; Respiratory Insufficiency; Rhabdomyolysis | 1996 |
Unusual opioid withdrawal syndrome. A case-report.
Topics: Aged; Colonic Neoplasms; Coma; Humans; Male; Methadone; Morphine; Neoplasm Recurrence, Local; Opium; | 1987 |
Methadone-induced pulmonary edema.
Topics: Adolescent; Coma; Cyanosis; Exudates and Transudates; Humans; Hypoventilation; Injections, Intraveno | 1972 |
Treatment of propoxyphene overdosage with naloxone.
Topics: Adult; Coma; Dextropropoxyphene; Female; Humans; Infant; Methadone; Naloxone; Poisoning | 1973 |
Drugs, coma, and myoglobinuria.
Topics: Acute Kidney Injury; Adult; Aspartate Aminotransferases; Barbiturates; Chlorpromazine; Coma; Drug-Re | 1972 |
Methadone-induced pulmonary edema.
Topics: Acute Disease; Administration, Oral; Adult; Coma; Female; Furosemide; Heroin; Humans; Hydrocortisone | 1971 |