Page last updated: 2024-10-30

methadone and Coma

methadone has been researched along with Coma in 16 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
"Acute respiratory distress syndrome (ARDS) due to methadone (MTD) toxicity is a known but rather uncommon phenomenon."7.79Acute respiratory distress syndrome caused by methadone syrup. ( Aghabiklooei, A; Hassanian-Moghaddam, H; Shadnia, S; Zamani, N, 2013)
" Acute poisoning occurred after taking 100 ml of 1,4-butanediol together with phenyl-2- (1-pyrrolidinyl) -1-pentanone and 2 g of methadone, clinically manifested in the form of convulsive syndrome, depression of consciousness to the level of coma 3, edema and swelling brain, acute respiratory failure, mixed decompensated respiratory and metabolic lactic acidosis (pH 7."4.12[CLINICAL CASE OF ACUTE SEVERE COMBINED POISONING WITH NARCOTIC SUBSTANCES OF DEPENDENT AND PSYCHOSTIMULATING EFFECTS]. ( Antonova, A; Batotsyrenov, B; Kovalenko, A; Lodyagin, A; Loladze, A; Sinenchenko, A, 2022)
"Acute respiratory distress syndrome (ARDS) due to methadone (MTD) toxicity is a known but rather uncommon phenomenon."3.79Acute respiratory distress syndrome caused by methadone syrup. ( Aghabiklooei, A; Hassanian-Moghaddam, H; Shadnia, S; Zamani, N, 2013)
"We report on the preclinical management of a 4-year-old child who was found in a comatose condition with respiratory failure after accidental ingestion of methadone."3.72[Preclinical management of accidental methadone intoxication of a 4-year-old girl. Antagonist or intubation?]. ( Bernhard, M; Gries, A; Hainer, C, 2004)
" On reduction of opioid dosage he had visual and auditory hallucinations and showed deterioration of consciousness progressing to coma."1.27Unusual opioid withdrawal syndrome. A case-report. ( Grochow, LB; Hausheer, F; Kumor, KM, 1987)
"In cases associated with coma, the pathophysiology is secondary to local pressure necrosis caused by compression from the patient's own body."1.26Rhabdomyolysis secondary to drug overdose and prolonged coma. ( Chaikin, HL, 1980)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19907 (43.75)18.7374
1990's1 (6.25)18.2507
2000's2 (12.50)29.6817
2010's3 (18.75)24.3611
2020's3 (18.75)2.80

Authors

AuthorsStudies
Sinenchenko, A1
Lodyagin, A1
Loladze, A1
Batotsyrenov, B1
Antonova, A1
Kovalenko, A1
Hermansen, SK1
Christoffersen, DJ1
Mehrpour, O1
Hoyte, C1
Amirabadizadeh, A1
Brent, J1
Aghabiklooei, A1
Shadnia, S1
Hassanian-Moghaddam, H1
Zamani, N1
Martin, M1
Daoudal, P1
Bein, C1
Bazzi, N1
Bourscheid, D1
Floriot, C1
Hayashi, T1
Schönfeld, C1
Tsokos, M1
Hantson, P1
Vanbinst, R1
Wallemacq, P1
Hainer, C1
Bernhard, M1
Gries, A1
van den Brink, RB1
Wilmink, JM1
Vreeken, J1
Chaikin, HL1
Froomes, PR1
Haddad, J1
Harding, D1
Kumor, KM1
Grochow, LB1
Hausheer, F1
Frand, UI1
Shim, CS1
Williams, MH1
Kersh, ES1
Penn, AS1
Rowland, LP1
Fraser, DW1
Kjeldgaard, JM1
Hahn, GW1
Heckenlively, JR1
Genton, E1

Other Studies

16 other studies available for methadone and Coma

ArticleYear
[CLINICAL CASE OF ACUTE SEVERE COMBINED POISONING WITH NARCOTIC SUBSTANCES OF DEPENDENT AND PSYCHOSTIMULATING EFFECTS].
    Georgian medical news, 2022, Issue:324

    Topics: Adult; Coma; Cross Infection; Humans; Hypoxia; Lactic Acid; Methadone; Narcotics

2022
Common opioids and stimulants in autopsy and DUID cases: A comparison of measured concentrations.
    Forensic science international, 2022, Volume: 338

    Topics: Amphetamine; Analgesics, Opioid; Autopsy; Central Nervous System Stimulants; Cocaine; Coma; Heroin;

2022
Clinical characteristics and time trends of hospitalized methadone exposures in the United States based on the Toxicology Investigators Consortium (ToxIC) case registry: 2010-2017.
    BMC pharmacology & toxicology, 2020, 07-22, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Child; Child, Preschool; Coma; Drug Overdose; Female; H

2020
Acute respiratory distress syndrome caused by methadone syrup.
    Arhiv za higijenu rada i toksikologiju, 2013, Volume: 64, Issue:3

    Topics: Administration, Oral; Adult; Coma; Drug Compounding; Drug Overdose; Female; Humans; Male; Methadone;

2013
[Inhaled methadone-induced non cardiogenic pulmonary edema with Acute Respiratory Distress Syndrome].
    Presse medicale (Paris, France : 1983), 2011, Volume: 40, Issue:4 Pt 1

    Topics: Administration, Inhalation; Coma; Female; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pu

2011
"Cobblestone" appearance of the ascending colon.
    Forensic science, medicine, and pathology, 2013, Volume: 9, Issue:2

    Topics: Adult; Alcoholism; Analgesics, Opioid; Benzodiazepines; Cause of Death; Colon; Coma; Crohn Disease;

2013
Accidental methadone overdose in an opiate-naive elderly patient.
    Intensive care medicine, 2003, Volume: 29, Issue:11

    Topics: Aged; Coma; Critical Care; Drug Overdose; Female; Humans; Medication Errors; Methadone; Narcotics; P

2003
[Preclinical management of accidental methadone intoxication of a 4-year-old girl. Antagonist or intubation?].
    Der Anaesthesist, 2004, Volume: 53, Issue:10

    Topics: Analgesics, Opioid; Child, Preschool; Coma; Emergency Medical Services; Female; Humans; Intubation,

2004
[The importance of an accurate preoperative anamnesis].
    Nederlands tijdschrift voor geneeskunde, 1982, Oct-02, Volume: 126, Issue:40

    Topics: Coma; Diuretics; Drug Synergism; Humans; Kidney Tubules; Lithium; Male; Medical History Taking; Meth

1982
Rhabdomyolysis secondary to drug overdose and prolonged coma.
    Southern medical journal, 1980, Volume: 73, Issue:8

    Topics: Acute Kidney Injury; Adult; Coma; Humans; Hypocalcemia; Male; Mescaline; Methadone; Myoglobin; Myogl

1980
Coma, myalagia and hypoxia.
    Postgraduate medical journal, 1996, Volume: 72, Issue:852

    Topics: Adult; Coma; Humans; Male; Methadone; Respiratory Insufficiency; Rhabdomyolysis

1996
Unusual opioid withdrawal syndrome. A case-report.
    Lancet (London, England), 1987, Mar-28, Volume: 1, Issue:8535

    Topics: Aged; Colonic Neoplasms; Coma; Humans; Male; Methadone; Morphine; Neoplasm Recurrence, Local; Opium;

1987
Methadone-induced pulmonary edema.
    Annals of internal medicine, 1972, Volume: 76, Issue:6

    Topics: Adolescent; Coma; Cyanosis; Exudates and Transudates; Humans; Hypoventilation; Injections, Intraveno

1972
Treatment of propoxyphene overdosage with naloxone.
    Chest, 1973, Volume: 63, Issue:1

    Topics: Adult; Coma; Dextropropoxyphene; Female; Humans; Infant; Methadone; Naloxone; Poisoning

1973
Drugs, coma, and myoglobinuria.
    Archives of neurology, 1972, Volume: 26, Issue:4

    Topics: Acute Kidney Injury; Adult; Aspartate Aminotransferases; Barbiturates; Chlorpromazine; Coma; Drug-Re

1972
Methadone-induced pulmonary edema.
    JAMA, 1971, Nov-08, Volume: 218, Issue:6

    Topics: Acute Disease; Administration, Oral; Adult; Coma; Female; Furosemide; Heroin; Humans; Hydrocortisone

1971