methadone and Cognition Disorders studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

Excerpt	Relevance	Reference
"To evaluate the impaired attention selection (Stroop interference effect) and general performance [reaction times (RTs)] on the Stroop task among methadone maintenance treatment (MMT) patients with obsessive compulsive disorder (OCD), pathological gambling (PG), both PG/OCD or none, and the influence if having ADHD."	7.80	Stroop task among patients with obsessive-compulsive disorder (OCD) and pathological gambling (PG) in methadone maintenance treatment (MMT). ( Adelson, M; Peles, E; Sason, A; Schreiber, S; Weinstein, A, 2014)
"To evaluate the impaired attention selection (Stroop interference effect) and general performance [reaction times (RTs)] on the Stroop task among methadone maintenance treatment (MMT) patients with obsessive compulsive disorder (OCD), pathological gambling (PG), both PG/OCD or none, and the influence if having ADHD."	3.80	Stroop task among patients with obsessive-compulsive disorder (OCD) and pathological gambling (PG) in methadone maintenance treatment (MMT). ( Adelson, M; Peles, E; Sason, A; Schreiber, S; Weinstein, A, 2014)
"Prior research has demonstrated neuropsychological (NP) impairment in persons with histories of injection drug use (IDU), hepatitis C virus (HCV) infection, and methadone maintenance treatment (MMT), individually, but little is known about the NP effects of these three risk factors in combination."	3.80	Absence of neurocognitive impairment in a large Chinese sample of HCV-infected injection drug users receiving methadone treatment. ( Duarte, N; Franklin, DR; Grant, I; Gupta, S; Hampton Atkinson, J; Heaton, RK; Iudicello, JE; Jin, H; Knight, A; Letendre, S; Li, J; Riggs, PK; Shi, C; Wu, Z; Yu, X, 2014)
" A 61-year-old man presented with severe cognitive dysfunction after long-term methadone treatment for intercostal neuralgia and was diagnosed with GH insufficiency by GH releasing hormone-arginine testing."	3.80	Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids. ( Gordh, T; Grönbladh, A; Nyberg, F; Ortiz-Nieto, F; Raininko, R; Rhodin, A; Skottheim, B; von Ehren, M, 2014)
" In the present paper, we compared the decision-making ability using the Iowa gambling task of methadone- and buprenorphine-maintained individuals to non opiate-dependent drug-free controls."	3.73	Impaired decision-making in opiate-dependent subjects: effect of pharmacological therapies. ( Bini, V; Diana, M; Fais, R; Falconieri, D; Messina, M; Pirastu, R; Spiga, S, 2006)
"An accumulating body of research suggests that former heroin abusers in methadone maintenance therapy (MMT) exhibit deficits in cognitive function."	3.73	Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment. ( Cohen, LJ; Eisenberg, D; Galynker, II; London, ED; Prosser, J; Steinfeld, M, 2006)
" Cognitive testing took place at 2 time points: study weeks 4 through 5 to assess baseline performance and 10 to 13 weeks later to assess performance during stable dosing (300 mg topiramate or placebo)."	2.80	Topiramate impairs cognitive function in methadone-maintained individuals with concurrent cocaine dependence. ( Bigelow, GE; Johnson, MW; Mintzer, MZ; Rass, O; Strain, EC; Umbricht, A, 2015)
"5mg) may be an effective mechanism for safely dosing this medication in persons with higher levels of physical dependence."	2.73	Sublingual buprenorphine/naloxone precipitated withdrawal in subjects maintained on 100mg of daily methadone. ( Bigelow, GE; Rosado, J; Strain, EC; Walsh, SL, 2007)
"Severity of opioid dependence, and performance on two successive runs of the Wisconsin Card Sorting Test (WCST), were assessed in 39 right-handed male and female methadone patients who had been randomly assigned to either a recently dosed (n=21) or 24 hr abstinent (n=18) condition."	2.71	Neuropsychological correlates of opioid dependence and withdrawal. ( Lyvers, M; Yakimoff, M, 2003)
"This hypothesis predicts that drug abusers should excel on tests of knowledge that is related to their lifestyle."	2.69	Forms of knowledge, cognitive impairment and drug abuse: a demonstration. ( Beatty, WW; Borrell, GK, 2000)
"Methadone has been used as a pharmacotherapy for the treatment of opiate dependence since the mid-1960s."	2.49	Methadone maintenance treatment and cognitive function: a systematic review. ( Russell, BR; Wang, GY; Wouldes, TA, 2013)
"Methadone maintenance treatment (MMT) has been used to treat opiate dependence since the mid-1960s."	1.40	Neuropsychological performance of methadone-maintained opiate users. ( Jensen, M; Kydd, R; Russell, BR; Wang, GY; Wouldes, TA, 2014)
"Thirty HIV-negative substance users were individually matched to 30 HIV-positive substance users on relevant medical and demographic factors, including reading level and methadone therapy status."	1.39	Isolating cognitive and neurologic HIV effects in substance-dependent, confounded cohorts: a pilot study. ( Byrd, DA; Elliott, K; Lighty, Q; Mindt, MR; Mintz, L; Morgello, S; Robinson-Papp, J, 2013)
"Buprenorphine-treated patients performed statistically significantly better in a simple reaction time test than methadone-treated ones."	1.38	Do drug treatment variables predict cognitive performance in multidrug-treated opioid-dependent patients? A regression analysis study. ( Alho, H; Fabritius, C; Kalska, H; Rapeli, P, 2012)
"Methadone-treated patients, as a group, had significantly slower simple reaction time (RT) compared to buprenorphine/naloxone-treated patients."	1.34	Methadone vs. buprenorphine/naloxone during early opioid substitution treatment: a naturalistic comparison of cognitive performance relative to healthy controls. ( Alho, H; Fabritius, C; Kalska, H; Rapeli, P; Salaspuro, M; Wahlbeck, K, 2007)
"A life-time diagnosis of alcohol dependence and the number of non-fatal heroin overdoses were independent significant predictors of poorer cognitive performance."	1.31	Cognitive impairment among methadone maintenance patients. ( Darke, S; McDonald, S; Sims, J; Wickes, W, 2000)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (6.06)	18.7374
1990's	5 (15.15)	18.2507
2000's	16 (48.48)	29.6817
2010's	10 (30.30)	24.3611
2020's	0 (0.00)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Amantadine for Neuroenhancement in Acute Patients Study - A Prospective Pilot Proof of Concept Phase IIb Study in Intensive and Intermediate Care Unit Patients[NCT05479032]	Phase 2	50 participants (Anticipated)	Interventional	2022-09-30	Not yet recruiting
Treatment of Adult ADHD in Methadone Patients[NCT00061087]	Phase 2/Phase 3	115 participants (Actual)	Interventional	1998-02-28	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Topiramate impairs cognitive function in methadone-maintained individuals with concurrent cocaine dependence. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 2015, Volume: 29, Issue:1 Topics: Adult; Cocaine-Related Disorders; Cognition Disorders; Diagnosis, Dual (Psychiatry); Double-Blind Me	2015
Neuropsychological functioning of opiate-dependent patients: a nonrandomized comparison of patients preferring either buprenorphine or methadone maintenance treatment. The American journal of drug and alcohol abuse, 2008, Volume: 34, Issue:5 Topics: Adult; Analgesics, Opioid; Buprenorphine; Cognition Disorders; Dose-Response Relationship, Drug; Fem	2008
Neuropsychological correlates of opioid dependence and withdrawal. Addictive behaviors, 2003, Volume: 28, Issue:3 Topics: Adolescent; Adult; Cognition Disorders; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Neu	2003
Sublingual buprenorphine/naloxone precipitated withdrawal in subjects maintained on 100mg of daily methadone. Drug and alcohol dependence, 2007, Oct-08, Volume: 90, Issue:2-3 Topics: Administration, Sublingual; Adult; Buprenorphine; Cognition Disorders; Double-Blind Method; Drug Com	2007
Forms of knowledge, cognitive impairment and drug abuse: a demonstration. Progress in neuro-psychopharmacology & biological psychiatry, 2000, Volume: 24, Issue:1 Topics: Adult; Cocaine-Related Disorders; Cognition Disorders; Female; Humans; Knowledge; Male; Methadone; M	2000

Article	Year
Isolating cognitive and neurologic HIV effects in substance-dependent, confounded cohorts: a pilot study. Journal of the International Neuropsychological Society : JINS, 2013, Volume: 19, Issue:4 Topics: Adult; Cognition Disorders; Cohort Studies; Female; HIV Infections; Humans; Male; Methadone; Middle	2013
Stroop task among patients with obsessive-compulsive disorder (OCD) and pathological gambling (PG) in methadone maintenance treatment (MMT). CNS spectrums, 2014, Volume: 19, Issue:6 Topics: Adult; Age Factors; Aged; Analgesics, Opioid; Analysis of Variance; Attention Deficit Disorder with	2014
Absence of neurocognitive impairment in a large Chinese sample of HCV-infected injection drug users receiving methadone treatment. Drug and alcohol dependence, 2014, Apr-01, Volume: 137 Topics: Adult; Asian People; Cognition Disorders; Female; Hepatitis C; Humans; Male; Methadone; Neuropsychol	2014
Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids. Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:6 Topics: Apoptosis; Arginine; Aspartic Acid; Cognition Disorders; Creatine; Growth Hormone; Growth Hormone-Re	2014
Neuropsychological performance of methadone-maintained opiate users. Journal of psychopharmacology (Oxford, England), 2014, Volume: 28, Issue:8 Topics: Adolescent; Adult; Attention; Case-Control Studies; Cognition Disorders; Drug Users; Executive Funct	2014
Differences in methylphenidate abuse rates among methadone maintenance treatment patients in two clinics. Journal of substance abuse treatment, 2015, Volume: 54 Topics: Adult; Attention Deficit Disorder with Hyperactivity; Benzodiazepines; Central Nervous System Stimul	2015
Clinical and diagnostic features of delayed hypoxic leukoencephalopathy. The Journal of neuropsychiatry and clinical neurosciences, 2008,Fall, Volume: 20, Issue:4 Topics: Adult; Analgesics, Opioid; Benzodiazepines; Brain; Cocaine; Cognition Disorders; Depressive Disorder	2008
Do drug treatment variables predict cognitive performance in multidrug-treated opioid-dependent patients? A regression analysis study. Substance abuse treatment, prevention, and policy, 2012, Nov-02, Volume: 7 Topics: Adult; Analgesics, Opioid; Attention; Buprenorphine; Cognition Disorders; Drug Therapy, Combination;	2012
Deficits in social perception in opioid maintenance patients, abstinent opioid users and non-opioid users. Addiction (Abingdon, England), 2013, Volume: 108, Issue:3 Topics: Adult; Analysis of Variance; Buprenorphine; Case-Control Studies; Cognition Disorders; Emotions; Fem	2013
Factors affecting cognitive functioning in a sample of human immunodeficiency virus-positive injection drug users. AIDS patient care and STDs, 2002, Volume: 16, Issue:6 Topics: Adult; CD4 Lymphocyte Count; Cognition Disorders; Educational Status; Female; HIV Infections; HIV-1;	2002
Amantadine for neurobehavioural deficits following delayed post-hypoxic encephalopathy. Brain injury, 2004, Volume: 18, Issue:12 Topics: Adult; Amantadine; Brain; Brain Injuries; Cognition Disorders; Demyelinating Diseases; Diazepam; Dop	2004
Neuropsychological functioning in methadone maintenance patients versus abstinent heroin abusers. Drug and alcohol dependence, 2005, Jun-01, Volume: 78, Issue:3 Topics: Adult; Alcoholism; Cocaine-Related Disorders; Cognition Disorders; Female; Heroin Dependence; Humans	2005
Impaired decision-making in opiate-dependent subjects: effect of pharmacological therapies. Drug and alcohol dependence, 2006, Jun-28, Volume: 83, Issue:2 Topics: Adult; Buprenorphine; Cognition Disorders; Decision Making; Female; Gambling; Humans; Male; Methadon	2006
Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment. Drug and alcohol dependence, 2006, Oct-01, Volume: 84, Issue:3 Topics: Adult; Cognition Disorders; Demography; Female; Heroin Dependence; Humans; Male; Mass Screening; Met	2006
Assessment of cognitive functioning of methadone-maintenance patients: impact of adult ADHD and current cocaine dependence. Journal of addictive diseases, 2006, Volume: 25, Issue:4 Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cocaine-Related Disorders; Cognition Disorders	2006
Do we undervalue feelings in patients who are cognitively impaired? The Journal of clinical ethics, 2006,Winter, Volume: 17, Issue:4 Topics: Aggression; Alzheimer Disease; Analgesics, Opioid; Anger; Anxiety; Brain Injuries; Cognition; Cognit	2006
Methadone vs. buprenorphine/naloxone during early opioid substitution treatment: a naturalistic comparison of cognitive performance relative to healthy controls. BMC clinical pharmacology, 2007, Jun-12, Volume: 7 Topics: Adult; Buprenorphine; Cognition; Cognition Disorders; Drug Therapy, Combination; Female; Humans; Mal	2007
[Long-term treatment with opioids and cognition disorders]. Ugeskrift for laeger, 1994, Jan-10, Volume: 156, Issue:2 Topics: Analgesics, Opioid; Cognition Disorders; Humans; Methadone; Narcotics; Opioid-Related Disorders; Tim	1994
Relationship of beta 2 microglobulin and CD4 counts to neuropsychological performance in HIV-1-infected intravenous drug users. Journal of acquired immune deficiency syndromes, 1994, Volume: 7, Issue:10 Topics: Adult; Analysis of Variance; beta 2-Microglobulin; CD4-Positive T-Lymphocytes; Cognition Disorders;	1994
Magnetic resonance abnormalities in HIV infection: a study in the drug-user risk group. Psychiatry research, 1993, Volume: 47, Issue:2 Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; Brain; Brain Diseases; Cognition D	1993
[Melatonin, methadone, tacrine, vitamin K antagonists and low-molecular-weight heparin]. Revue medicale de Bruxelles, 1996, Volume: 17, Issue:4 Topics: Aged; Anticoagulants; Cholinesterase Inhibitors; Circadian Rhythm; Cognition Disorders; Heroin Depen	1996
Attention deficit hyperactivity disorder and treatment outcome in opioid abusers entering treatment. The Journal of nervous and mental disease, 1999, Volume: 187, Issue:8 Topics: Adult; Ambulatory Care; Attention; Attention Deficit Disorder with Hyperactivity; Clonidine; Cogniti	1999
Cognitive impairment among methadone maintenance patients. Addiction (Abingdon, England), 2000, Volume: 95, Issue:5 Topics: Adult; Aged; Alcoholism; Case-Control Studies; Cognition Disorders; Craniocerebral Trauma; Drug Over	2000
Cognitive impairment in methadone maintenance patients. Drug and alcohol dependence, 2002, Jun-01, Volume: 67, Issue:1 Topics: Adult; Cocaine; Cocaine-Related Disorders; Cognition Disorders; Concept Formation; Female; Heroin; H	2002
Neuropsychological deficits and opiate abuse. Drug and alcohol dependence, 2002, Jun-01, Volume: 67, Issue:1 Topics: Adult; Cognition Disorders; Female; Follow-Up Studies; Humans; Male; Methadone; Middle Aged; Narcoti	2002
Personality characteristics in a sample of heroin addict methadone maintenance applicants. The British journal of addiction to alcohol and other drugs, 1976, Volume: 71, Issue:3 Topics: Adult; Affective Symptoms; Arizona; Cognition Disorders; Female; Heroin Dependence; Humans; Male; Me	1976
A prospective longitudinal study of neuropsychological and psychosocial factors in asymptomatic individuals at risk for HTLV-III/LAV infection in a methadone program: preliminary findings. The International journal of neuroscience, 1987, Volume: 32, Issue:3-4 Topics: Acquired Immunodeficiency Syndrome; Cognition Disorders; Heroin Dependence; Humans; Longitudinal Stu	1987

methadone and Cognition Disorders

Research Excerpts

Research

Studies (33)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Byrd, DA	1
Robinson-Papp, J	1
Mindt, MR	1
Mintz, L	1
Elliott, K	1
Lighty, Q	1
Morgello, S	1
Wang, GY	2
Wouldes, TA	2
Russell, BR	2
Peles, E	2
Weinstein, A	1
Sason, A	1
Adelson, M	2
Schreiber, S	2
Gupta, S	1
Iudicello, JE	1
Shi, C	1
Letendre, S	1
Knight, A	1
Li, J	1
Riggs, PK	1
Franklin, DR	1
Duarte, N	1
Jin, H	1
Hampton Atkinson, J	1
Yu, X	1
Wu, Z	1
Grant, I	1
Heaton, RK	1
Rhodin, A	1
von Ehren, M	1
Skottheim, B	1
Grönbladh, A	1
Ortiz-Nieto, F	1
Raininko, R	1
Gordh, T	1
Nyberg, F	1
Kydd, R	1
Jensen, M	1
Rass, O	1
Umbricht, A	1
Bigelow, GE	2
Strain, EC	2
Johnson, MW	1
Mintzer, MZ	2
Linzy, S	1
Domani, Y	1
Loeber, S	1
Kniest, A	1
Diehl, A	1
Mann, K	1
Croissant, B	1
Shprecher, DR	1
Flanigan, KM	1
Smith, AG	1
Smith, SM	1
Schenkenberg, T	1
Steffens, J	1
Rapeli, P	2
Fabritius, C	2
Kalska, H	2
Alho, H	2
McDonald, S	2
Darke, S	2
Kaye, S	1
Torok, M	1
Margolin, A	1
Avants, SK	1
Warburton, LA	1
Hawkins, KA	1
Lyvers, M	1
Yakimoff, M	1
Arciniegas, DB	1
Frey, KL	1
Anderson, CA	1
Brousseau, KM	1
Harris, SN	1
Verdejo, A	1
Toribio, I	1
Orozco, C	1
Puente, KL	1
Pérez-García, M	1
Pirastu, R	1
Fais, R	1
Messina, M	1
Bini, V	1
Spiga, S	1
Falconieri, D	1
Diana, M	1
Prosser, J	1
Cohen, LJ	1
Steinfeld, M	1
Eisenberg, D	1
London, ED	1
Galynker, II	1
Brooks, DJ	1
Vosburg, SK	1
Evans, SM	1
Levin, FR	1
Howe, EG	1
Rosado, J	1
Walsh, SL	1
Salaspuro, M	1
Wahlbeck, K	1
Ege, PP	1
Boccellari, AA	1
Chambers, DB	1
Dilley, JW	1
Shore, MD	1
Tauber, MA	1
Moss, AR	1
Osmond, DH	1
Handelsman, L	1
Song, IS	1
Losonczy, M	1
Park, S	1
Jacobson, J	1
Wiener, J	1
Aronson, M	1
Sternon, J	1
King, VL	1
Brooner, RK	1
Kidorf, MS	1
Stoller, KB	1
Mirsky, AF	1
Beatty, WW	1
Borrell, GK	1
Sims, J	1
Wickes, W	1
Stitzer, ML	1
Davis, PE	1
Liddiard, H	1
McMillan, TM	1
Herl, D	1
Silberstein, CH	1
McKegney, FP	1
O'Dowd, MA	1
Selwyn, PA	1
Schoenbaum, E	1
Drucker, E	1
Feiner, C	1
Cox, CP	1
Friedland, G	1