methadone has been researched along with Chronic Illness in 142 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of the study was to describe the experience of methadone use in 100 consecutive chronic pain patients managed in a single multidisciplinary center." | 9.13 | Experience of methadone therapy in 100 consecutive chronic pain patients in a multidisciplinary pain center. ( Evans, D; Galonski, M; Gordon, A; Gourlay, D; Peng, P; Stafford, M; Tumber, P; Wong, P, 2008) |
| "Methadone is effective for chronic cancer pain, but its early pharmacodynamic profile and effectiveness for breakthrough pain remain uncertain." | 9.11 | Characterization of the early pharmacodynamic profile of oral methadone for cancer-related breakthrough pain: a pilot study. ( Fisher, K; Hagen, NA; Stiles, C, 2004) |
| "The aim of this study is to characterize patients with chronic pain in methadone maintenance treatment (MMT)." | 9.11 | Significantly higher methadone dose for methadone maintenance treatment (MMT) patients with chronic pain. ( Adelson, M; Gordon, J; Peles, E; Schreiber, S, 2005) |
| "Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain." | 8.86 | Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010) |
| "Methadone is increasingly prescribed for chronic pain, yet the associated mortality appears to be rising disproportionately relative to other opioid analgesics." | 8.85 | Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation. ( Andrews, CM; Capacchione, JF; Haigney, MC; Krantz, MJ; Marcuson, MJ; Wedam, EF, 2009) |
| "This topical review addresses methadone's pharmacology, its application in malignant and non-malignant pain conditions, practical issues related to methadone for the treatment of pain and its influence on QTc time." | 8.84 | Clinical pharmacology of methadone for pain. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Moksnes, K, 2008) |
| "This article reviews the unique pharmacological properties of methadone and outlines its appropriate clinical application, with focus upon its use in the treatment of chronic pain." | 8.82 | Methadone: applied pharmacology and use as adjunctive treatment in chronic pain. ( Brown, R; Fleming, M; Kraus, C; Reddy, S, 2004) |
| "Methadone, although having been available for approximately half a century, is now receiving increasing attention in the management of chronic pain." | 8.82 | A review of the use of methadone for the treatment of chronic noncancer pain. ( Lynch, ME, 2005) |
| "The aim of this study was to compare the burden of chronic disease, multi-morbidity and intensity of health-service use between methadone-maintained patients (MMPs) and matched controls in primary care." | 7.80 | Methadone-maintained patients in primary care have higher rates of chronic disease and multimorbidity, and use health services more intensively than matched controls. ( Cox, AM; Darker, C; Hambly, R; O'Shea, B; O'Toole, J, 2014) |
| "Risk factors in older methadone maintenance treatment (MMT) patients may put them at a greater risk of acquiring chronic diseases; however, this group might experience barriers to treatment resulting in reduced recommended prescriptions." | 7.79 | Hypertension, chronic obstructive pulmonary disease, diabetes and depression among older methadone maintenance patients in British Columbia. ( Borycki, E; Macdonald, S; Maruyama, A; Zhao, J, 2013) |
| "The reports on pain perception among former heroin addicts receiving methadone maintenance treatment (MMT) vary with regard to pain and intolerance threshold, and perception of suprathreshold stimuli has not been previously evaluated." | 7.77 | The differential effect of methadone dose and of chronic pain on pain perception of former heroin addicts receiving methadone maintenance treatment. ( Adelson, M; Defrin, R; Hetzroni, T; Peles, E; Schreiber, S, 2011) |
| "Methadone is an excellent choice for pain in frail older adults." | 7.75 | Methadone: an effective, safe drug of first choice for pain management in frail older adults. ( Gallagher, R, 2009) |
| "Following the findings of perceived poor sleep and of chronic pain among former heroin addicts, current methadone maintenance treatment (MMT) patients, and its possible relation to methadone dose, we studied these patients' objective sleep parameters." | 7.75 | Documented poor sleep among methadone-maintained patients is associated with chronic pain and benzodiazepine abuse, but not with methadone dose. ( Adelson, M; Peles, E; Schreiber, S, 2009) |
| "Differences in psychiatric distress and substance use (licit and illicit) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences." | 7.75 | Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2009) |
| "Methadone treatment in chronic pain patients is still limited owing to misconceptions about addiction, safety, and its unique pharmacokinetic and pharmacodynamic properties." | 7.74 | Nurse case management program of chronic pain patients treated with methadone. ( Lamb, L; Pereira, JX; Shir, Y, 2007) |
| "The use of methadone may be difficult and its use in the treatment of chronic non-malignant pain is only sparsely described in literature, whereas several works have shown the advantage of methadone in the treatment of cancer pain." | 7.74 | [Methadone in the treatment of chronic non-malignant pain]. ( Bendiksen, A; Handberg, G; McGehee, E, 2007) |
| "The case of a patient who developed edema after receiving methadone for chronic low back pain is reported." | 7.74 | Edema in a patient receiving methadone for chronic low back pain. ( Kharlamb, V; Kourlas, H, 2007) |
| "Iatrogenic opioid addiction among chronic pain patients was the initiative for starting a methadone programme for pain patients at the University Hospital of Uppsala." | 7.73 | Methadone treatment of chronic non-malignant pain and opioid dependence--a long-term follow-up. ( Gordh, T; Grönbladh, L; Nilsson, LH; Rhodin, A, 2006) |
| "Although studies on the beliefs of persons with chronic nonmalignant pain (CNMP) are still scarce, methadone is increasingly prescribed for the treatment of CNMP." | 7.73 | Response phases in methadone treatment for chronic nonmalignant pain. ( Arnaert, A; Ciccotosto, G, 2006) |
| "Twelve patients with poor pain control or unacceptable side effects during treatment with morphine were switched to methadone and followed for nine months in this open prospective study." | 7.73 | Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Klepstad, P; Landrø, NI, 2006) |
| "Recent studies indicate that severe chronic pain is common among patients in methadone maintenance treatment (MMT), but no qualitative studies have examined such patients' experiences of pain and pain treatment." | 7.72 | The experience of chronic severe pain in patients undergoing methadone maintenance treatment. ( Arnstein, J; Arnsten, JH; Berg, K; Gourevitch, M; Karasz, A; Selwyn, P; Zallman, L, 2004) |
| "To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy." | 7.72 | Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004) |
| "The objectives of this medico-legal case report were the following: 1) To present an example of a medico-legal problem that developed as a result of a decision to rotate a chronic pain patient (CPP) to methadone in order to taper the CPP from oxycodone; 2) To present both the plaintiff's and defendant's expert witnesses' opinions as to if and where the care of that patient fell below the "standard of medical care;" and 3) Based on these opinions, to develop some recommendations on how, in the future, pain medicine physicians and other physicians should proceed, in order to avoid allegations of breach of "standards of care" when using methadone." | 7.72 | Medico-legal rounds: medico-legal issues and alleged breaches of "standards of medical care" in opioid rotation to methadone: a case report. ( Cole, B; Cutler, RB; Fishbain, DA; Lewis, J; Rosomoff, HL; Rosomoff, RS, 2003) |
| "To estimate the prevalence and to examine the characteristics of chronic severe pain in chemically dependent populations receiving methadone maintenance or inpatient residential treatment." | 7.72 | Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. ( Cleland, C; Fong, C; Joseph, H; Kipnis, S; Portenoy, RK; Rosenblum, A, 2003) |
| "The usefulness of beta-hexosaminidase (uHex) and gamma-glutamyltransferase (uGGT) activity in urine as markers of chronic alcohol abuse was examined in male methadone programme participants." | 7.71 | The activity of beta-hexosaminidase (uHex) and gamma-glutamyltransferase (uGGT) in urine as non-invasive markers of chronic alcohol abuse: II. Opiate-dependent subjects receiving methadone substitution. ( Baran, H; Chmielewska, K; Habrat, B; Szukalski, B; Taracha, E; Walkowiak, J, 2002) |
| "To evaluate a series of methadone-treated patients experiencing torsade de pointes." | 7.71 | Torsade de pointes associated with very-high-dose methadone. ( Hays, H; Krantz, MJ; Lewkowiez, L; Mehler, PS; Robertson, AD; Woodroffe, MA, 2002) |
| "Chronic pain patients who have limited access to opioids may be redirected to methadone maintenance centers for management of their pain." | 7.70 | Characteristics of methadone maintenance patients with chronic pain. ( Jamison, RN; Katz, NP; Kauffman, J, 2000) |
| "Five patients with chronic nonmalignant pain were transferred from other analgesics to oral methadone." | 7.69 | Oral methadone for managing chronic nonmalignant pain. ( Gardner-Nix, JS, 1996) |
| "Concentrations of methadone in plasma, estimates of pain relief, and pupillary size were determined after a single intravenous dose (10 to 30 mg) of methadone hydrochloride to eight patients with chronic pain, five of whom had cancer." | 7.67 | Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain. ( Colburn, WA; Foley, KM; Houde, RW; Inturrisi, CE; Kaiko, RF, 1987) |
| " The pharmacokinetic parameters of the R- and S-enantiomers of the racemate are reported." | 6.68 | Stereoselective pharmacokinetics of methadone in chronic pain patients. ( Angelo, HR; Blemmer, T; Christrup, LL; Drenck, NE; Kristensen, K; Rasmussen, SN; Sjøgren, P, 1996) |
| "Methadone is a synthetic opioid with potent analgesic effects." | 6.43 | Methadone treatment for pain states. ( Kral, LA; Toombs, JD, 2005) |
| "The objective of the study was to describe the experience of methadone use in 100 consecutive chronic pain patients managed in a single multidisciplinary center." | 5.13 | Experience of methadone therapy in 100 consecutive chronic pain patients in a multidisciplinary pain center. ( Evans, D; Galonski, M; Gordon, A; Gourlay, D; Peng, P; Stafford, M; Tumber, P; Wong, P, 2008) |
| "The aim of this study is to characterize patients with chronic pain in methadone maintenance treatment (MMT)." | 5.11 | Significantly higher methadone dose for methadone maintenance treatment (MMT) patients with chronic pain. ( Adelson, M; Gordon, J; Peles, E; Schreiber, S, 2005) |
| "Methadone is effective for chronic cancer pain, but its early pharmacodynamic profile and effectiveness for breakthrough pain remain uncertain." | 5.11 | Characterization of the early pharmacodynamic profile of oral methadone for cancer-related breakthrough pain: a pilot study. ( Fisher, K; Hagen, NA; Stiles, C, 2004) |
| "Thirty-three consecutive patients with primary chronic daily headache were managed according to a treatment pathway which involved sequential administration of divalproex sodium, amitriptyline, amitriptyline plus phenelzine, or methadone." | 5.09 | Management of chronic daily headache utilizing a uniform treatment pathway. ( Rothrock, JF, 1999) |
| "Methadone was responsible for the most deaths at 10 (50%), and hydrocodone was second at four deaths (20%) The most common risk factors found in the medical records of decedents included prescriber error in initiating, converting or titrating doses, patient nonadherence to medical instruction, presence of comorbid mental disorders, toxicological presence of benzodiazepines, middle age, and unrelieved pain." | 4.87 | A review of forensic implications of opioid prescribing with examples from malpractice cases involving opioid-related overdose. ( Rich, BA; Webster, LR, 2011) |
| "Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain." | 4.86 | Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010) |
| "Methadone is increasingly prescribed for chronic pain, yet the associated mortality appears to be rising disproportionately relative to other opioid analgesics." | 4.85 | Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation. ( Andrews, CM; Capacchione, JF; Haigney, MC; Krantz, MJ; Marcuson, MJ; Wedam, EF, 2009) |
| "This topical review addresses methadone's pharmacology, its application in malignant and non-malignant pain conditions, practical issues related to methadone for the treatment of pain and its influence on QTc time." | 4.84 | Clinical pharmacology of methadone for pain. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Moksnes, K, 2008) |
| "Methadone, although having been available for approximately half a century, is now receiving increasing attention in the management of chronic pain." | 4.82 | A review of the use of methadone for the treatment of chronic noncancer pain. ( Lynch, ME, 2005) |
| "This article reviews the unique pharmacological properties of methadone and outlines its appropriate clinical application, with focus upon its use in the treatment of chronic pain." | 4.82 | Methadone: applied pharmacology and use as adjunctive treatment in chronic pain. ( Brown, R; Fleming, M; Kraus, C; Reddy, S, 2004) |
| "The aim of this study was to compare the burden of chronic disease, multi-morbidity and intensity of health-service use between methadone-maintained patients (MMPs) and matched controls in primary care." | 3.80 | Methadone-maintained patients in primary care have higher rates of chronic disease and multimorbidity, and use health services more intensively than matched controls. ( Cox, AM; Darker, C; Hambly, R; O'Shea, B; O'Toole, J, 2014) |
| "Risk factors in older methadone maintenance treatment (MMT) patients may put them at a greater risk of acquiring chronic diseases; however, this group might experience barriers to treatment resulting in reduced recommended prescriptions." | 3.79 | Hypertension, chronic obstructive pulmonary disease, diabetes and depression among older methadone maintenance patients in British Columbia. ( Borycki, E; Macdonald, S; Maruyama, A; Zhao, J, 2013) |
| " Conversely, oral oxycodone and methadone were ineffective in controlling chronic pain despite high doses and aggressive titration." | 3.78 | Unpredictable absorption of oral opioid medications in a quadriplegic patient with chronic enterocutaneous fistulas. ( Viswesh, VV, 2012) |
| "The reports on pain perception among former heroin addicts receiving methadone maintenance treatment (MMT) vary with regard to pain and intolerance threshold, and perception of suprathreshold stimuli has not been previously evaluated." | 3.77 | The differential effect of methadone dose and of chronic pain on pain perception of former heroin addicts receiving methadone maintenance treatment. ( Adelson, M; Defrin, R; Hetzroni, T; Peles, E; Schreiber, S, 2011) |
| "To investigate the possibility of utilizing the ratio of the methadone metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), to urine creatinine to develop a regression model that would predict drug adherence in patients prescribed methadone for either pain management or drug addiction." | 3.75 | Quantification of a methadone metabolite (EDDP) in urine: assessment of compliance. ( Larson, ME; Richards, TM, 2009) |
| "Differences in psychiatric distress and substance use (licit and illicit) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences." | 3.75 | Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2009) |
| "A statistically significant association was found between diabetes mellitus and between liver and gastrointestinal cancer and premature mortality in this sample of older patients maintained on methadone (OR=30." | 3.75 | Benefits of retention in methadone maintenance and chronic medical conditions as risk factors for premature death among older heroin addicts. ( Amar, R; Casarella, J; Drexler, K; Fareed, A; Vayalapalli, S, 2009) |
| "This observational study aimed to determine whether pain sensitivity in patients with noncancer chronic pain, taking either methadone or morphine, is similar to patients maintained on methadone for dependence therapy, compared with a control group." | 3.75 | Hyperalgesia in opioid-managed chronic pain and opioid-dependent patients. ( Bochner, F; Hay, JL; Rounsefell, B; Semple, TJ; Somogyi, AA; White, JM, 2009) |
| "Following the findings of perceived poor sleep and of chronic pain among former heroin addicts, current methadone maintenance treatment (MMT) patients, and its possible relation to methadone dose, we studied these patients' objective sleep parameters." | 3.75 | Documented poor sleep among methadone-maintained patients is associated with chronic pain and benzodiazepine abuse, but not with methadone dose. ( Adelson, M; Peles, E; Schreiber, S, 2009) |
| "Methadone is an excellent choice for pain in frail older adults." | 3.75 | Methadone: an effective, safe drug of first choice for pain management in frail older adults. ( Gallagher, R, 2009) |
| " We sought first to explore providers' perceptions of ambiguity, and then to examine their strategies for making diagnostic and treatment decisions to manage chronic pain among patients on methadone maintenance therapy." | 3.75 | Providers' experiences treating chronic pain among opioid-dependent drug users. ( Arnsten, JH; Berg, KM; Karasz, A; Sacajiu, G, 2009) |
| " Fifty-seven patients were on methadone treatment, of whom 52(91%) had at least one chronic illness (other then substance use) and 39(68%) were prescribed at least one regular medication." | 3.75 | Chronic illness and multimorbidity among problem drug users: a comparative cross sectional pilot study in primary care. ( Bury, G; Cullen, W; O'Brien, S; O'Carroll, A; O'Kelly, FD, 2009) |
| "The use of methadone may be difficult and its use in the treatment of chronic non-malignant pain is only sparsely described in literature, whereas several works have shown the advantage of methadone in the treatment of cancer pain." | 3.74 | [Methadone in the treatment of chronic non-malignant pain]. ( Bendiksen, A; Handberg, G; McGehee, E, 2007) |
| "Methadone treatment in chronic pain patients is still limited owing to misconceptions about addiction, safety, and its unique pharmacokinetic and pharmacodynamic properties." | 3.74 | Nurse case management program of chronic pain patients treated with methadone. ( Lamb, L; Pereira, JX; Shir, Y, 2007) |
| "The case of a patient who developed edema after receiving methadone for chronic low back pain is reported." | 3.74 | Edema in a patient receiving methadone for chronic low back pain. ( Kharlamb, V; Kourlas, H, 2007) |
| "Among the many patients served by methadone maintenance treatment programs (MMTPs) is a small population with severe, refractory pain that may be effectively managed using long-term opioid therapy." | 3.74 | MMTP patients with chronic pain switching to pain management clinics. A problem or an acceptable practice? ( Altilio, T; Bookbinder, M; Cruciani, RA; Esteban, S; Portenoy, RK; Seewald, RM; Sheu, R, 2008) |
| "Twelve patients with poor pain control or unacceptable side effects during treatment with morphine were switched to methadone and followed for nine months in this open prospective study." | 3.73 | Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Klepstad, P; Landrø, NI, 2006) |
| "Iatrogenic opioid addiction among chronic pain patients was the initiative for starting a methadone programme for pain patients at the University Hospital of Uppsala." | 3.73 | Methadone treatment of chronic non-malignant pain and opioid dependence--a long-term follow-up. ( Gordh, T; Grönbladh, L; Nilsson, LH; Rhodin, A, 2006) |
| "Although studies on the beliefs of persons with chronic nonmalignant pain (CNMP) are still scarce, methadone is increasingly prescribed for the treatment of CNMP." | 3.73 | Response phases in methadone treatment for chronic nonmalignant pain. ( Arnaert, A; Ciccotosto, G, 2006) |
| "To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy." | 3.72 | Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004) |
| "The objectives of this medico-legal case report were the following: 1) To present an example of a medico-legal problem that developed as a result of a decision to rotate a chronic pain patient (CPP) to methadone in order to taper the CPP from oxycodone; 2) To present both the plaintiff's and defendant's expert witnesses' opinions as to if and where the care of that patient fell below the "standard of medical care;" and 3) Based on these opinions, to develop some recommendations on how, in the future, pain medicine physicians and other physicians should proceed, in order to avoid allegations of breach of "standards of care" when using methadone." | 3.72 | Medico-legal rounds: medico-legal issues and alleged breaches of "standards of medical care" in opioid rotation to methadone: a case report. ( Cole, B; Cutler, RB; Fishbain, DA; Lewis, J; Rosomoff, HL; Rosomoff, RS, 2003) |
| "Recent studies indicate that severe chronic pain is common among patients in methadone maintenance treatment (MMT), but no qualitative studies have examined such patients' experiences of pain and pain treatment." | 3.72 | The experience of chronic severe pain in patients undergoing methadone maintenance treatment. ( Arnstein, J; Arnsten, JH; Berg, K; Gourevitch, M; Karasz, A; Selwyn, P; Zallman, L, 2004) |
| "To estimate the prevalence and to examine the characteristics of chronic severe pain in chemically dependent populations receiving methadone maintenance or inpatient residential treatment." | 3.72 | Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. ( Cleland, C; Fong, C; Joseph, H; Kipnis, S; Portenoy, RK; Rosenblum, A, 2003) |
| "The usefulness of beta-hexosaminidase (uHex) and gamma-glutamyltransferase (uGGT) activity in urine as markers of chronic alcohol abuse was examined in male methadone programme participants." | 3.71 | The activity of beta-hexosaminidase (uHex) and gamma-glutamyltransferase (uGGT) in urine as non-invasive markers of chronic alcohol abuse: II. Opiate-dependent subjects receiving methadone substitution. ( Baran, H; Chmielewska, K; Habrat, B; Szukalski, B; Taracha, E; Walkowiak, J, 2002) |
| "To evaluate a series of methadone-treated patients experiencing torsade de pointes." | 3.71 | Torsade de pointes associated with very-high-dose methadone. ( Hays, H; Krantz, MJ; Lewkowiez, L; Mehler, PS; Robertson, AD; Woodroffe, MA, 2002) |
| " The delay in N75 latency was strongly correlated with self-reported years of heroin abuse, but not with years of cocaine, alcohol, or other drug abuse." | 3.70 | Effects of chronic opioid dependence and HIV-1 infection on pattern shift visual evoked potentials. ( Bauer, LO, 1998) |
| "Chronic pain patients who have limited access to opioids may be redirected to methadone maintenance centers for management of their pain." | 3.70 | Characteristics of methadone maintenance patients with chronic pain. ( Jamison, RN; Katz, NP; Kauffman, J, 2000) |
| "Five patients with chronic nonmalignant pain were transferred from other analgesics to oral methadone." | 3.69 | Oral methadone for managing chronic nonmalignant pain. ( Gardner-Nix, JS, 1996) |
| "Determination of methadone (MET) in biological fluids can serve to adjust dosages in patients suffering from cancer pain or participating in methadone maintenance programs." | 3.68 | Rapid determination of methadone in plasma, cerebrospinal fluid, and urine by gas chromatography and its application to routine drug monitoring. ( Brune, K; Geisslinger, G; Schmidt, N; Sittl, R, 1993) |
| "Concentrations of methadone in plasma, estimates of pain relief, and pupillary size were determined after a single intravenous dose (10 to 30 mg) of methadone hydrochloride to eight patients with chronic pain, five of whom had cancer." | 3.67 | Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain. ( Colburn, WA; Foley, KM; Houde, RW; Inturrisi, CE; Kaiko, RF, 1987) |
| " Among 42 active heroin users or former heroin addicts maintained on methadone, 79% were heavy alcohol abusers." | 3.65 | The spectrum and causes of liver diseases in narcotic addicts. ( Gelb, AM; Mildvan, D; Stenger, RJ, 1977) |
| " The pharmacokinetic parameters of the R- and S-enantiomers of the racemate are reported." | 2.68 | Stereoselective pharmacokinetics of methadone in chronic pain patients. ( Angelo, HR; Blemmer, T; Christrup, LL; Drenck, NE; Kristensen, K; Rasmussen, SN; Sjøgren, P, 1996) |
| "Many patients with opioid use disorder are treated in primary care, where effective addiction treatment can be provided." | 2.61 | Opioid Use Disorder: Medical Treatment Options. ( Coffa, D; Snyder, H, 2019) |
| " This article reviews the World Health Organization recommendations for analgesic therapy in this setting, as well as guidelines for opioid therapy in patients with renal failure or hepatic failure, assessment of pain, dosing strategies in both acute and chronic pain, management of opioid overdose, pain associated with dose-limiting side effects, and pain in the actively dying." | 2.44 | Practical guide to opioids and their complications in managing cancer pain. What oncologists need to know. ( Davis, MP; Gamier, P; Lasheen, W, 2007) |
| "Pain is a multidimensional symptom that can overshadow all other experiences of both the child and family." | 2.44 | The management of pain in children with life-limiting illnesses. ( Friedrichsdorf, SJ; Kang, TI, 2007) |
| "Methadone is a synthetic opioid with potent analgesic effects." | 2.43 | Methadone treatment for pain states. ( Kral, LA; Toombs, JD, 2005) |
| " Regular pain assessments combined with appropriate analgesic administration at regular dosing intervals, adjunctive drug therapy for control of adverse effects and associated symptoms, and nonpharmacological interventions are recommended." | 2.42 | Cancer pain management in children. ( Mercadante, S, 2004) |
| "Since this operation a recurrence of the displacement has not been observed and consecutively the filling of the pump could be accomplished without radiological investigations." | 1.36 | [Displaced pain pump because of a pendulous abdomen - dermatolipectomy as solution of the problem]. ( Föhn, M; Oehy, K; Vetter, M; Wedler, V, 2010) |
| "Injection users are at risk for vascular injuries resulting in chronic venous disease (CVD)." | 1.36 | Injection-related venous disease and walking mobility. ( Birk, TJ; Kirsner, RS; Pieper, B; Templin, TN, 2010) |
| "Addiction to opioids, or opioid dependence, encompasses the biopsychosocial dysfunction seen in illicit heroin injectors, as well as aberrant behaviours in patients prescribed opioids for chronic nonmalignant pain." | 1.36 | Opioid dependence - management in general practice. ( Frei, M, 2010) |
| "The challenge is not in treating pain, but identifying true pain from drug-seeking behaviors." | 1.35 | Chronic pain in patients with substance abuse disorder: general guidelines and an approach to treatment. ( Dewey, CM; Mitchell, AM, 2008) |
| "Levorphanol has been reported to provide analgesia at doses that suggest it does not act like other pure agonist opioids." | 1.34 | Can levorphanol be used like methadone for intractable refractory pain? ( McNulty, JP, 2007) |
| "Pain was associated with an increased propensity for misuse of substances with analgesic effects, suggesting that ongoing pain contributes to an altered and more severe pattern of drug-seeking behavior." | 1.32 | Treatment needs associated with pain in substance use disorder patients: implications for concurrent treatment. ( Horst, DA; Humphreys, K; Minkel, JD; Oliva, EM; Trafton, JA, 2004) |
| "In patients with a history of substance abuse, these are often serious developments to which a clinician must know how to react." | 1.32 | Opioid therapy in patients with a history of substance abuse. ( Kirsh, KL; Passik, SD, 2004) |
| "Conventional pharmacotherapies against neuropathic pain were attempted to control pain for over 5 years." | 1.31 | Successful use of methadone in the treatment of chronic neuropathic pain arising from burn injuries: a case-study. ( Altier, N; Boulanger, A; Choinière, M; Dion, D, 2001) |
| "Methadone has many pharmacokinetic characteristics that fit it for use in this clinical situation." | 1.30 | Treatment of pain in chronic bowel subobstruction with self-administration of methadone. ( Mercadante, S; Sapio, M; Serretta, R, 1997) |
| "Seventy cancer patients suffering from visceral or somatic pain received continuous epidural methadone (EM) analgesia." | 1.28 | Continuous epidural methadone treatment for cancer pain. ( Kaufman, B; Magora, F; Shapira, SS; Shenkman, Z; Shir, Y, 1991) |
| " As expected, the dosage intervals increased gradually over the first few days of treatment, the daily dose decreasing from 30-80 mg on the first day to 10-40 mg at the end of the week." | 1.26 | Patient-controlled dose regimen of methadone for chronic cancer pain. ( Anggård, E; Ginman, C; Hansen, J; Hartvig, P; Jakobsson, PA; Nilsson, MI; Rane, A; Säwe, J, 1981) |
| " The data suggest that the maintenance dosage of methadone need not be changed in stable chronic liver disease." | 1.26 | Methadone disposition in patients with chronic liver disease. ( Fanizza, AM; Gelb, AM; Kreek, MJ; Novick, DM; Stenger, RJ; Yancovitz, SR, 1981) |
| " Unit dose packaging is used because the oral solid dosage forms (including placebos) are made to look alike." | 1.25 | Drug use and distribution in a pain rehabilitation center. ( Beckner, TF; Idsvoog, P, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (23.94) | 18.7374 |
| 1990's | 14 (9.86) | 18.2507 |
| 2000's | 69 (48.59) | 29.6817 |
| 2010's | 23 (16.20) | 24.3611 |
| 2020's | 2 (1.41) | 2.80 |
| Authors | Studies |
|---|---|
| Coffa, D | 1 |
| Snyder, H | 1 |
| Mazahery, C | 1 |
| Benson, BL | 1 |
| Cruz-Lebrón, A | 1 |
| Levine, AD | 1 |
| Wang, L | 1 |
| Hu, F | 1 |
| Wang, W | 1 |
| Li, Q | 1 |
| Li, Y | 1 |
| Zhu, J | 1 |
| Qin, Y | 1 |
| Shi, H | 1 |
| Li, W | 1 |
| Wang, Y | 1 |
| Aiyer, R | 1 |
| Gulati, A | 1 |
| Gungor, S | 1 |
| Bhatia, A | 1 |
| Mehta, N | 1 |
| Maruyama, A | 1 |
| Macdonald, S | 1 |
| Borycki, E | 1 |
| Zhao, J | 1 |
| Sharif, B | 1 |
| Nosyk, B | 2 |
| Sun, H | 1 |
| Marsh, DC | 2 |
| Anis, A | 1 |
| Byford, S | 1 |
| Barrett, B | 1 |
| Metrebian, N | 1 |
| Groshkova, T | 1 |
| Cary, M | 1 |
| Charles, V | 1 |
| Lintzeris, N | 1 |
| Strang, J | 2 |
| Olsen, Y | 1 |
| Sharfstein, JM | 1 |
| O'Toole, J | 1 |
| Hambly, R | 1 |
| Cox, AM | 1 |
| O'Shea, B | 1 |
| Darker, C | 1 |
| Doukas, N | 1 |
| Robertson, JR | 1 |
| Robertson, AR | 1 |
| Gossop, M | 1 |
| Klimas, J | 1 |
| Keane, A | 1 |
| Cullen, W | 2 |
| O'Kelly, F | 1 |
| Bury, G | 2 |
| Rosen, D | 1 |
| Smith, ML | 1 |
| Reynolds, CF | 1 |
| Peng, P | 1 |
| Tumber, P | 1 |
| Stafford, M | 1 |
| Gourlay, D | 1 |
| Wong, P | 1 |
| Galonski, M | 1 |
| Evans, D | 1 |
| Gordon, A | 1 |
| Burgess, FW | 2 |
| Pawasauskas, J | 1 |
| Cone, EJ | 1 |
| Caplan, YH | 1 |
| Black, DL | 1 |
| Robert, T | 1 |
| Moser, F | 1 |
| Blondell, RD | 1 |
| Ashrafioun, L | 1 |
| Hay, JL | 1 |
| White, JM | 1 |
| Bochner, F | 1 |
| Somogyi, AA | 1 |
| Semple, TJ | 1 |
| Rounsefell, B | 1 |
| Berg, KM | 1 |
| Arnsten, JH | 2 |
| Sacajiu, G | 1 |
| Karasz, A | 2 |
| Kritz, S | 1 |
| Chu, M | 1 |
| John-Hull, C | 1 |
| Madray, C | 1 |
| Louie, B | 1 |
| Brown, LS | 1 |
| Gallagher, R | 1 |
| Hanlon, JT | 1 |
| Weiner, DK | 1 |
| O'Brien, S | 1 |
| O'Carroll, A | 1 |
| O'Kelly, FD | 1 |
| Peles, E | 3 |
| Schreiber, S | 3 |
| Adelson, M | 4 |
| Andrews, CM | 1 |
| Krantz, MJ | 2 |
| Wedam, EF | 1 |
| Marcuson, MJ | 1 |
| Capacchione, JF | 1 |
| Haigney, MC | 1 |
| Järvinen, M | 1 |
| Andersen, D | 1 |
| Fareed, A | 1 |
| Casarella, J | 1 |
| Amar, R | 1 |
| Vayalapalli, S | 1 |
| Drexler, K | 1 |
| Barry, DT | 1 |
| Beitel, M | 1 |
| Garnet, B | 1 |
| Joshi, D | 1 |
| Rosenblum, A | 2 |
| Schottenfeld, RS | 1 |
| McNulty, JP | 2 |
| Larson, ME | 1 |
| Richards, TM | 1 |
| Modesto-Lowe, V | 1 |
| Brooks, D | 1 |
| Petry, N | 1 |
| Vetter, M | 1 |
| Föhn, M | 1 |
| Oehy, K | 1 |
| Wedler, V | 1 |
| Grant, KJ | 1 |
| Baca, CT | 1 |
| Hetzroni, T | 1 |
| Defrin, R | 1 |
| Frei, M | 1 |
| Pieper, B | 1 |
| Templin, TN | 1 |
| Kirsner, RS | 1 |
| Birk, TJ | 1 |
| Senbanjo, R | 1 |
| Hunt, N | 1 |
| Silver, N | 1 |
| Allen, RP | 1 |
| Senerth, J | 1 |
| Earley, CJ | 1 |
| Rich, BA | 1 |
| Webster, LR | 1 |
| Karch, SB | 1 |
| Guh, DP | 1 |
| Bansback, NJ | 1 |
| Oviedo-Joekes, E | 1 |
| Brissette, S | 1 |
| Meikleham, E | 1 |
| Schechter, MT | 1 |
| Anis, AH | 1 |
| Viswesh, VV | 1 |
| Lewkowiez, L | 1 |
| Hays, H | 1 |
| Woodroffe, MA | 1 |
| Robertson, AD | 1 |
| Mehler, PS | 1 |
| Hopper, JA | 1 |
| Shafi, T | 1 |
| Miles, J | 1 |
| Taracha, E | 1 |
| Habrat, B | 1 |
| Baran, H | 1 |
| Chmielewska, K | 1 |
| Walkowiak, J | 1 |
| Szukalski, B | 1 |
| Foley, KM | 2 |
| Joseph, H | 1 |
| Fong, C | 1 |
| Kipnis, S | 1 |
| Cleland, C | 1 |
| Portenoy, RK | 2 |
| Fishbain, DA | 1 |
| Cutler, RB | 1 |
| Cole, B | 1 |
| Lewis, J | 1 |
| Rosomoff, RS | 1 |
| Rosomoff, HL | 1 |
| Streltzer, J | 2 |
| Kosten, TR | 2 |
| Trafton, JA | 1 |
| Oliva, EM | 1 |
| Horst, DA | 1 |
| Minkel, JD | 1 |
| Humphreys, K | 1 |
| Sharpe, C | 1 |
| Kuschel, C | 1 |
| Passik, SD | 1 |
| Kirsh, KL | 1 |
| Mercadante, S | 3 |
| Zallman, L | 1 |
| Berg, K | 1 |
| Gourevitch, M | 1 |
| Selwyn, P | 1 |
| Arnstein, J | 1 |
| Brown, R | 1 |
| Kraus, C | 1 |
| Fleming, M | 1 |
| Reddy, S | 1 |
| Fisher, K | 1 |
| Stiles, C | 1 |
| Hagen, NA | 1 |
| Gordon, J | 1 |
| Housová, J | 1 |
| Wilczek, H | 1 |
| Haluzík, MM | 1 |
| Kremen, J | 1 |
| Krízová, J | 1 |
| Haluzík, M | 1 |
| Toombs, JD | 1 |
| Kral, LA | 1 |
| Dijkgraaf, MG | 1 |
| van der Zanden, BP | 1 |
| de Borgie, CA | 1 |
| Blanken, P | 1 |
| van Ree, JM | 1 |
| van den Brink, W | 1 |
| Rhodin, A | 1 |
| Grönbladh, L | 1 |
| Nilsson, LH | 1 |
| Gordh, T | 1 |
| Lynch, ME | 1 |
| Dart, RC | 1 |
| Woody, GE | 1 |
| Kleber, HD | 1 |
| Moulin, DE | 1 |
| Lipman, AG | 1 |
| Fredheim, OM | 3 |
| Kaasa, S | 3 |
| Dale, O | 3 |
| Klepstad, P | 2 |
| Landrø, NI | 1 |
| Borchgrevink, PC | 3 |
| Arnaert, A | 1 |
| Ciccotosto, G | 1 |
| Johansen, L | 1 |
| Sullivan, MD | 1 |
| Leigh, J | 1 |
| Gaster, B | 1 |
| Bendiksen, A | 1 |
| McGehee, E | 1 |
| Handberg, G | 1 |
| Schwartz, RP | 1 |
| McKenzie, M | 1 |
| Rich, JD | 1 |
| Patane', S | 1 |
| Marte, F | 1 |
| Di Bella, G | 1 |
| Chiribiri, A | 1 |
| Lamb, L | 1 |
| Pereira, JX | 1 |
| Shir, Y | 2 |
| Davis, MP | 1 |
| Lasheen, W | 1 |
| Gamier, P | 1 |
| Friedrichsdorf, SJ | 1 |
| Kang, TI | 1 |
| Kharlamb, V | 1 |
| Kourlas, H | 1 |
| Skeie, I | 1 |
| Brekke, M | 1 |
| Lindbaek, M | 1 |
| Waal, H | 1 |
| Moksnes, K | 1 |
| Cruciani, RA | 1 |
| Esteban, S | 1 |
| Seewald, RM | 1 |
| Altilio, T | 1 |
| Bookbinder, M | 1 |
| Sheu, R | 1 |
| Mitchell, AM | 1 |
| Dewey, CM | 1 |
| Halpern, L | 1 |
| Tennant, FS | 1 |
| Gourlay, GK | 1 |
| Cousins, MJ | 1 |
| Säwe, J | 1 |
| Hansen, J | 1 |
| Ginman, C | 1 |
| Hartvig, P | 1 |
| Jakobsson, PA | 1 |
| Nilsson, MI | 1 |
| Rane, A | 1 |
| Anggård, E | 1 |
| Powers, DA | 1 |
| Hamilton, CW | 1 |
| Roberts, KB | 1 |
| Kreek, MJ | 4 |
| Bencsath, FA | 2 |
| Fanizza, A | 1 |
| Field, FH | 2 |
| Lööf, G | 1 |
| Paalzow, L | 1 |
| Jaspersen, HP | 1 |
| Portnow, JM | 1 |
| Corbett, RJ | 1 |
| Novick, DM | 1 |
| Fanizza, AM | 1 |
| Yancovitz, SR | 1 |
| Gelb, AM | 2 |
| Stenger, RJ | 2 |
| Schmidt, N | 1 |
| Sittl, R | 1 |
| Brune, K | 1 |
| Geisslinger, G | 1 |
| Gardner-Nix, JS | 1 |
| Kristensen, K | 1 |
| Blemmer, T | 1 |
| Angelo, HR | 1 |
| Christrup, LL | 1 |
| Drenck, NE | 1 |
| Rasmussen, SN | 1 |
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| Sapio, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| MOms in REcovery (MORE): Defining Optimal Care for Pregnant Women and Infants[NCT04251208] | 444 participants (Actual) | Observational | 2019-07-30 | Active, not recruiting | |||
| Influence of Aging on Perioperative Methadone Dosing[NCT04526236] | Phase 4 | 60 participants (Actual) | Interventional | 2019-09-03 | Completed | ||
| Effect of Opioid Taper on Pain Responses in Patients With Chronic Pain[NCT03912298] | 7 participants (Actual) | Observational | 2019-04-15 | Completed | |||
| An Open-label, Randomised Pilot Study Comparing the Efficacy, Safety and Tolerability of Raltegravir With Protease Inhibitor-based Therapy in Treatment-naïve, HIV/Hepatitis C Co-infected Injecting Drug Users Receiving Methadone[NCT01105611] | Phase 4 | 40 participants (Anticipated) | Interventional | 2010-08-31 | Recruiting | ||
| The Norwegian Addiction, Pain and Trauma Study[NCT04908410] | 1,500 participants (Anticipated) | Observational | 2021-03-23 | Recruiting | |||
| Descriptive, Prospective Study of the Characteristics of Chronic Pain in Patients With Addiction to at Least One Substance[NCT05976178] | 300 participants (Anticipated) | Observational | 2022-12-10 | Recruiting | |||
| Pomegranate Juice Consumption by Patients Under Medication for Addiction Treatment as a Regulator of Craving and Blood Redox Status: The Study Protocol of a Randomized Control Trial (the NUTRIDOPE Study)[NCT05861544] | 58 participants (Anticipated) | Interventional | 2023-03-23 | Enrolling by invitation | |||
| Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone in Human Subjects[NCT00504413] | Phase 1 | 20 participants (Anticipated) | Interventional | 2007-07-31 | Recruiting | ||
| Does Intraoperative Methadone Prevent Postoperative Pain in Bariatric Surgery?[NCT02775474] | Phase 4 | 32 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Opioid Switching From Oral Slow Release Morphine to Oral Methadone May Improve Pain Control in Chronic Non-malignant Pain: a Nine-month Follow-up Study.[NCT00356083] | Phase 3 | 12 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Conditioned pain modulation will be measured using the quantitative sensory testing (QST) employing procedures consistent with those described in the literature to capture supra-spinal mechanisms of OIH. To detect conditioned modulation, the subject is asked to verbally report the severity of pain experienced on a visual analogue scale (0- no pain, 10-worst pain ever) to a three-second painful heat stimulus (47○C) delivered at 12-15 second intervals, in the presence or absence of the non-dominant limb being immerged in a cold-water bath (12○C). The reported value is the difference between the average of pain scores reported in the absence of vs. the presence of the counter-stimulation. Reported are changes in the conditioned pain modulation assay both prior to and following taper. Taper is individualized thus length of taper varies between subjects. (NCT03912298)
Timeframe: up to one year (individualized, variable taper length)
| Intervention | units on a visual analogue scale (Mean) | |
|---|---|---|
| pre-taper conditioned pain modulation (baseline) | post taper conditioned pain modulation (individualized taper, thus time length varies) | |
| Chronic Pain Patients Undergoing Opioid Taper | -0.14 | -0.40 |
Pain perception will be measured using the cold-pressor test (CPT) employing procedures consistent with those described in the literature. Order of pain testing will vary, and three aspects of the pain response will be captured at each study session: evoked pain; temporal summation; and conditioned pain modulation, which map on to the hypothesized peripheral, spinal and supra-spinal mechanisms of OIH. Reported are cold-pressor pain tolerance prior to and following taper. (NCT03912298)
Timeframe: up to one year (length of taper individualized and varies)
| Intervention | seconds (Mean) | |
|---|---|---|
| pre taper pain tolerance (baseline) | post-taper pain tolerance (timeframe variable) | |
| Chronic Pain Patients Undergoing Opioid Taper | 24.01 | 42.02 |
21 reviews available for methadone and Chronic Illness
| Article | Year |
|---|---|
Opioid Use Disorder: Medical Treatment Options.
Topics: Analgesics, Opioid; Buprenorphine; Chronic Disease; Evidence-Based Medicine; Female; Humans; Male; M | 2019 |
Treatment of Chronic Pain With Various Buprenorphine Formulations: A Systematic Review of Clinical Studies.
Topics: Administration, Buccal; Administration, Cutaneous; Administration, Sublingual; Analgesics, Opioid; B | 2018 |
Responding to illicit drug use in family practice.
Topics: Analgesics, Opioid; Buprenorphine; Chronic Disease; Disease Management; Family Practice; Humans; Ill | 2015 |
Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Chronic Disease; Delayed Rectifier Potassium Channels; ERG | 2009 |
Methadone deaths: risk factors in pain and addicted populations.
Topics: Analgesics, Opioid; Chronic Disease; Death, Sudden, Cardiac; Drug Overdose; Humans; Methadone; Opiat | 2010 |
A review of forensic implications of opioid prescribing with examples from malpractice cases involving opioid-related overdose.
Topics: Analgesics, Opioid; Chronic Disease; Drug Overdose; Drug Prescriptions; Forensic Medicine; Humans; K | 2011 |
Management of the hospitalized injection drug user.
Topics: Chronic Disease; Comorbidity; Female; Hospitalization; Humans; Male; Methadone; Pain; Severity of Il | 2002 |
Intrathecal therapy for chronic pain.
Topics: Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Hum | 2001 |
Methadone: applied pharmacology and use as adjunctive treatment in chronic pain.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Opioid-Related Disorders; Pain | 2004 |
Cancer pain management in children.
Topics: Analgesics, Opioid; Anesthesia, Conduction; Child; Chronic Disease; Fentanyl; Humans; Injections, Sp | 2004 |
Methadone treatment for pain states.
Topics: Analgesics, Opioid; Chronic Disease; Drug Costs; Drug Interactions; Humans; Methadone; Pain; Therape | 2005 |
Cost utility analysis of co-prescribed heroin compared with methadone maintenance treatment in heroin addicts in two randomised trials.
Topics: Administration, Inhalation; Adult; Chronic Disease; Cost of Illness; Cost-Benefit Analysis; Crime; D | 2005 |
A review of the use of methadone for the treatment of chronic noncancer pain.
Topics: Analgesics, Opioid; Canada; Chronic Disease; Humans; Legislation, Drug; Methadone; Pain | 2005 |
Opioid addiction and incarceration: an overview.
Topics: Analgesics, Opioid; Chronic Disease; Criminal Law; Forensic Psychiatry; Humans; Methadone; Opioid-Re | 2007 |
Practical guide to opioids and their complications in managing cancer pain. What oncologists need to know.
Topics: Analgesics, Opioid; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Routes; D | 2007 |
The management of pain in children with life-limiting illnesses.
Topics: Analgesics, Opioid; Child; Chronic Disease; Codeine; Fentanyl; Humans; Hydromorphone; Ketamine; Meth | 2007 |
Clinical pharmacology of methadone for pain.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Chronic Disease; Clinical Trials as Topic; Drug Interactio | 2008 |
[The practitioner and reduction of risks].
Topics: Aftercare; Chronic Disease; Humans; Methadone; Narcotics; Palliative Care; Physician's Role; Risk Fa | 1998 |
[Opiate addiction as a chronic brain disease: new concept of an old problem, and re-evaluation of methadone treatment].
Topics: Brain Diseases; Chronic Disease; Humans; Methadone; Narcotics; Opioid-Related Disorders | 2000 |
Medical complications in methadone patients.
Topics: Alcoholism; Analgesics; Anesthetics; Blood Proteins; Chronic Disease; Drug Interactions; Ethanol; Ho | 1978 |
[Antitussive agents. 34].
Topics: Acetylcysteine; Acute Disease; Alkaloids; Animals; Antitussive Agents; Bronchitis; Central Nervous S | 1969 |
9 trials available for methadone and Chronic Illness
| Article | Year |
|---|---|
Cost-effectiveness of injectable opioid treatment v. oral methadone for chronic heroin addiction.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Chronic Disease; Cost Savings; Cost-Benefit Analysis; C | 2013 |
Experience of methadone therapy in 100 consecutive chronic pain patients in a multidisciplinary pain center.
Topics: Ambulatory Care; Analgesics, Opioid; Canada; Chronic Disease; Female; Humans; Male; Methadone; Middl | 2008 |
Characterization of the early pharmacodynamic profile of oral methadone for cancer-related breakthrough pain: a pilot study.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Chronic Disease; Cross-Over Studies; Female; | 2004 |
Significantly higher methadone dose for methadone maintenance treatment (MMT) patients with chronic pain.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Benzodiazepines; Case-Control Studies; Chronic Dise | 2005 |
Brief report: Training internists in shared decision making about chronic opioid treatment for noncancer pain.
Topics: Analgesics, Opioid; Attitude of Health Personnel; Chronic Disease; Decision Making; Humans; Internal | 2006 |
Long term methadone for chronic pain: a pilot study of pharmacokinetic aspects.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Dose-Response Relationship, Drug; Drug Administrat | 2007 |
Stereoselective pharmacokinetics of methadone in chronic pain patients.
Topics: Aged; Analgesics, Opioid; Biological Availability; Chromatography, High Pressure Liquid; Chronic Dis | 1996 |
Management of chronic daily headache utilizing a uniform treatment pathway.
Topics: Adolescent; Adult; Amitriptyline; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Dru | 1999 |
Effect of methadone plus neuroleptics on treatment-resistant chronic paranoid schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Chronic Disease; Clinical Trials as Topic; Drug Therapy, Co | 1985 |
112 other studies available for methadone and Chronic Illness
| Article | Year |
|---|---|
Chronic Methadone Use Alters the CD8
Topics: Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD8-Positive T-Lymphocytes; Chronic Disease; | 2020 |
Altered brain intrinsic functional hubs and connectivity associated with relapse risk in heroin dependents undergoing methadone maintenance treatment: A resting-state fMRI study.
Topics: Adult; Brain; Brain Mapping; Cerebral Cortex; Chronic Disease; Female; Heroin; Heroin Dependence; Hu | 2021 |
Hypertension, chronic obstructive pulmonary disease, diabetes and depression among older methadone maintenance patients in British Columbia.
Topics: British Columbia; Case-Control Studies; Chronic Disease; Depression; Diabetes Mellitus; Drug Utiliza | 2013 |
Changes in the characteristics and levels of comorbidity among new patients into methadone maintenance treatment program in British Columbia during its expansion period from 1998-2006.
Topics: Adult; Age Factors; British Columbia; Canada; Chronic Disease; Comorbidity; Female; Humans; Male; Me | 2013 |
Confronting the stigma of opioid use disorder--and its treatment.
Topics: Buprenorphine; Chronic Disease; Criminal Law; Humans; Illicit Drugs; Methadone; Narcotic Antagonists | 2014 |
Methadone-maintained patients in primary care have higher rates of chronic disease and multimorbidity, and use health services more intensively than matched controls.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Cost-Benefit Analysis; Female; Follow-Up Studies; Health | 2014 |
Are methadone counselors properly equipped to meet the palliative care needs of older adults in methadone maintenance treatment? Implications for training.
Topics: Age Factors; Aged; Chronic Disease; Counseling; Female; Humans; Male; Methadone; Middle Aged; Needs | 2014 |
The National Treatment Outcomes Research Study (NTORS) and its influence on addiction treatment policy in the United Kingdom.
Topics: Chronic Disease; Crime; Health Policy; History, 20th Century; History, 21st Century; Humans; Methado | 2015 |
Seventeen year mortality in a cohort of patients attending opioid agonist treatment in Ireland. Commentary on 'methadone-maintained patients in primary care have higher rates of chronic disease' (O'Toole et al., European Journal of General Practice 2014;2
Topics: Chronic Disease; Female; Health Care Costs; Health Services; Hospitalization; Humans; Male; Methadon | 2016 |
The prevalence of mental and physical health disorders among older methadone patients.
Topics: Aged; Alcoholism; Anxiety Disorders; Chronic Disease; Comorbidity; Depressive Disorder, Major; Femal | 2008 |
Methadone analgesia for persistent pain: safety and toxicity considerations.
Topics: Analgesics, Opioid; Chronic Disease; Drug Interactions; Humans; Methadone; Pain | 2008 |
Urine drug testing of chronic pain patients: licit and illicit drug patterns.
Topics: Amphetamines; Analgesics, Opioid; Benzodiazepines; Cannabinoids; Carisoprodol; Chronic Disease; Huma | 2008 |
Treating opioid dependency and coexistent chronic nonmalignant pain.
Topics: Analgesics, Opioid; Buprenorphine; Chronic Disease; Humans; Methadone; Opioid-Related Disorders; Pai | 2008 |
Hyperalgesia in opioid-managed chronic pain and opioid-dependent patients.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Drug Tolerance; Female; Humans; Hyperalgesia; Male; Meth | 2009 |
Providers' experiences treating chronic pain among opioid-dependent drug users.
Topics: Chronic Disease; Decision Making; Delivery of Health Care, Integrated; Humans; Methadone; Opioid-Rel | 2009 |
Opioid dependence as a chronic disease: the interrelationships between length of stay, methadone dose, and age on treatment outcome at an urban opioid treatment program.
Topics: Adult; Age Factors; Chronic Disease; Ethnicity; Female; Humans; Length of Stay; Male; Methadone; Mid | 2009 |
Methadone: an effective, safe drug of first choice for pain management in frail older adults.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Female; Frail Elderly; Homes for the A | 2009 |
Methadone for chronic pain in older adults: blast from the past but are we ready for it to return to prime time?
Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain | 2009 |
Chronic illness and multimorbidity among problem drug users: a comparative cross sectional pilot study in primary care.
Topics: Adult; Chronic Disease; Comorbidity; Cross-Sectional Studies; Drug Users; Female; Harm Reduction; Hu | 2009 |
Documented poor sleep among methadone-maintained patients is associated with chronic pain and benzodiazepine abuse, but not with methadone dose.
Topics: Adult; Benzodiazepines; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Met | 2009 |
The making of the chronic addict.
Topics: Adult; Analgesics, Opioid; Behavior, Addictive; Chronic Disease; Denmark; Drug Users; Female; Harm R | 2009 |
Benefits of retention in methadone maintenance and chronic medical conditions as risk factors for premature death among older heroin addicts.
Topics: Age Factors; Aged; Cause of Death; Chronic Disease; Comorbidity; Diabetes Mellitus; Female; Gastroin | 2009 |
Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients.
Topics: Adult; Chronic Disease; Comorbidity; Connecticut; Female; Humans; Male; Mental Disorders; Methadone; | 2009 |
Chronic pain: levorphanol, methadone, and the N-methyl-D-aspartate receptor.
Topics: Analgesics, Opioid; Chronic Disease; Hospice Care; Humans; Levorphanol; Methadone; N-Methylaspartate | 2009 |
Quantification of a methadone metabolite (EDDP) in urine: assessment of compliance.
Topics: Analgesics, Opioid; Chronic Disease; Creatinine; Female; Follow-Up Studies; Humans; Male; Methadone; | 2009 |
[Displaced pain pump because of a pendulous abdomen - dermatolipectomy as solution of the problem].
Topics: Abdominal Fat; Adult; Amides; Analgesics, Opioid; Chronic Disease; Equipment Failure Analysis; Femal | 2010 |
Methadone deaths in pain and addiction populations.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain; Palliative Care; Substance-Related Dis | 2010 |
The differential effect of methadone dose and of chronic pain on pain perception of former heroin addicts receiving methadone maintenance treatment.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Chronic Disease; Dose-Response Relationship, Drug; | 2011 |
Opioid dependence - management in general practice.
Topics: Adult; Analgesics, Opioid; Australia; Buprenorphine; Chronic Disease; Disease Management; Female; Ge | 2010 |
Injection-related venous disease and walking mobility.
Topics: Adult; Aged; Chronic Disease; Cross-Sectional Studies; Female; Humans; Illicit Drugs; Leg Injuries; | 2010 |
Cessation of groin injecting behaviour among patients on oral opioid substitution treatment.
Topics: Adult; Chronic Disease; Cross-Sectional Studies; England; Female; Femoral Vein; Groin; Humans; Logis | 2011 |
A 10-year, longitudinal assessment of dopamine agonists and methadone in the treatment of restless legs syndrome.
Topics: Analgesics, Opioid; Benzothiazoles; Chronic Disease; Dopamine Agonists; Follow-Up Studies; Humans; K | 2011 |
Is it time to reformulate racemic methadone?
Topics: Adult; Arrhythmias, Cardiac; Chemistry, Pharmaceutical; Chronic Disease; Death, Sudden, Cardiac; Fem | 2011 |
Cost-effectiveness of diacetylmorphine versus methadone for chronic opioid dependence refractory to treatment.
Topics: Adult; Analgesics, Opioid; British Columbia; Chronic Disease; Cohort Studies; Cost-Benefit Analysis; | 2012 |
Unpredictable absorption of oral opioid medications in a quadriplegic patient with chronic enterocutaneous fistulas.
Topics: Administration, Oral; Analgesics, Opioid; Benzodiazepines; Biological Availability; Chronic Disease; | 2012 |
Torsade de pointes associated with very-high-dose methadone.
Topics: Adult; Analgesics, Opioid; Canada; Chronic Disease; Electrocardiography; Female; Heroin Dependence; | 2002 |
Summaries for patients. Very high doses of methadone may cause abnormal heart rhythm.
Topics: Adult; Analgesics, Opioid; Canada; Chronic Disease; Female; Heroin Dependence; Humans; Male; Methado | 2002 |
The activity of beta-hexosaminidase (uHex) and gamma-glutamyltransferase (uGGT) in urine as non-invasive markers of chronic alcohol abuse: II. Opiate-dependent subjects receiving methadone substitution.
Topics: Adult; Alcoholism; beta-N-Acetylhexosaminidases; Chronic Disease; Follow-Up Studies; gamma-Glutamylt | 2002 |
Opioids and chronic neuropathic pain.
Topics: Analgesics, Opioid; Chronic Disease; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Levor | 2003 |
Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Multivaria | 2003 |
Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Multivaria | 2003 |
Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Multivaria | 2003 |
Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Multivaria | 2003 |
Medico-legal rounds: medico-legal issues and alleged breaches of "standards of medical care" in opioid rotation to methadone: a case report.
Topics: Adult; Analgesics, Opioid; Autopsy; Chronic Disease; Decision Making; Expert Testimony; Florida; Hum | 2003 |
Methadone maintenance therapy and chronic pain.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain; Substance Abuse Treatment Centers; Sub | 2003 |
Treatment needs associated with pain in substance use disorder patients: implications for concurrent treatment.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Chronic Disease; Comorbidity; Cross-Sectional Studi | 2004 |
Outcomes of infants born to mothers receiving methadone for pain management in pregnancy.
Topics: Analgesics, Opioid; Chronic Disease; Delivery, Obstetric; Drug Administration Schedule; Female; Gest | 2004 |
Opioid therapy in patients with a history of substance abuse.
Topics: Chronic Disease; Drug Administration Schedule; Drug Tolerance; Humans; Medical History Taking; Metha | 2004 |
Switching to methadone: 'ad libitum' or fixed dose ratio?
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Morphine; Neoplasms; Pain; Patient Satisfact | 2004 |
The experience of chronic severe pain in patients undergoing methadone maintenance treatment.
Topics: Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Pain; Self Care; | 2004 |
Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment.
Topics: Adipocytes; Adiponectin; Adult; Body Mass Index; Chronic Disease; Female; Heroin Dependence; Hormone | 2005 |
Methadone treatment of chronic non-malignant pain and opioid dependence--a long-term follow-up.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Drug Administration Schedule; Female; Follow-Up St | 2006 |
Prescribing methadone as an analgesic.
Topics: Analgesics; Chronic Disease; Drug Administration Schedule; Half-Life; Humans; Methadone; Pain | 2005 |
Methadone--an old analgesic with new tricks.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain | 2005 |
Methadone: a double edged sword.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain | 2005 |
Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Chronic Disease; Delayed-Action Preparations; | 2006 |
Response phases in methadone treatment for chronic nonmalignant pain.
Topics: Adaptation, Psychological; Adult; Analgesics, Opioid; Causality; Chronic Disease; Family; Female; He | 2006 |
Prescription drug dependence and evolving beliefs about chronic pain management.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Drug Prescriptions; Drug Tolerance; Drug Utilization; Fe | 2006 |
Can levorphanol be used like methadone for intractable refractory pain?
Topics: Analgesics, Opioid; Chronic Disease; Hospice Care; Humans; Levorphanol; Louisiana; Methadone; Pain M | 2007 |
[Methadone in the treatment of chronic non-malignant pain].
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone | 2007 |
Acute myocardial infarction after consumption of aspirin in a chronic methadone user patient.
Topics: Adult; Aspirin; Chronic Disease; Cyclooxygenase Inhibitors; Electrocardiography; Humans; Male; Metha | 2007 |
Nurse case management program of chronic pain patients treated with methadone.
Topics: Aged; Ambulatory Care; Analgesics, Opioid; Case Management; Chronic Disease; Drug Monitoring; Feasib | 2007 |
Edema in a patient receiving methadone for chronic low back pain.
Topics: Chronic Disease; Edema; Female; Humans; Low Back Pain; Methadone; Middle Aged | 2007 |
Somatic health among heroin addicts before and during opioid maintenance treatment: a retrospective cohort study.
Topics: Acute Disease; Adult; Ambulatory Care; Chronic Disease; Cohort Studies; Drug Overdose; Female; Healt | 2008 |
MMTP patients with chronic pain switching to pain management clinics. A problem or an acceptable practice?
Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Heroin Dependence; Humans; Male; Methadone; Midd | 2008 |
Chronic pain in patients with substance abuse disorder: general guidelines and an approach to treatment.
Topics: Chronic Disease; Diagnosis, Differential; Humans; Methadone; Pain; Substance-Related Disorders | 2008 |
Substitution-detoxification and its role in the management of chronic benign pain.
Topics: Acute Disease; Analgesics, Opioid; Chronic Disease; Drug Administration Schedule; Humans; Hypnotics | 1982 |
(-)-alpha-Acetylmethadol for treatment of chronic pain patients who abuse opioids.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Methadyl Acetate; Middl | 1983 |
Strong analgesics in severe pain.
Topics: Analgesics, Opioid; Chronic Disease; Cocaine; Fentanyl; Half-Life; Heroin; Humans; Injections, Intra | 1984 |
Patient-controlled dose regimen of methadone for chronic cancer pain.
Topics: Adult; Aged; Chronic Disease; Drug Administration Schedule; Female; Humans; Male; Methadone; Middle | 1981 |
Pharmacist intervention in methadone administration to cancer patients with chronic pain.
Topics: Adolescent; Adult; Aged; Chronic Disease; Humans; Methadone; Middle Aged; Neoplasms; Pain; Pharmacis | 1983 |
Effects of liver disease on fecal excretion of methadone and its unconjugated metabolites in maintenance patients. Quantitation by direct probe chemical ionization mass spectrometry.
Topics: Chronic Disease; Feces; Female; Hepatitis; Heroin Dependence; Humans; Male; Mass Spectrometry; Metha | 1983 |
[Morphine and methadone in severe cancer pain--new pharmacokinetic bases for optimal therapy].
Topics: Chronic Disease; Humans; Kinetics; Methadone; Morphine; Neoplasms; Pain | 1983 |
Oral methadone for relief of chronic pain from cancer.
Topics: Chronic Disease; Humans; Methadone; Morphine; Neoplasms; Pain, Intractable | 1982 |
Methadone disposition in patients with chronic liver disease.
Topics: Administration, Oral; Adult; Alcoholism; Chronic Disease; Dose-Response Relationship, Drug; Female; | 1981 |
Effects of liver disease on urinary excretion of methadone and metabolites in maintenance patients: quantitation by direct probe chemical ionization mass spectrometry.
Topics: Chronic Disease; Female; Heroin Dependence; Humans; Liver Diseases; Male; Mass Spectrometry; Methado | 1980 |
Rapid determination of methadone in plasma, cerebrospinal fluid, and urine by gas chromatography and its application to routine drug monitoring.
Topics: Chromatography, Gas; Chronic Disease; Drug Monitoring; Heroin Dependence; Humans; Methadone; Pain; Q | 1993 |
Oral methadone for managing chronic nonmalignant pain.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; M | 1996 |
Abstinence symptomatology associated with cessation of chronic cocaine abuse among methadone-maintained patients.
Topics: Adult; Chronic Disease; Cocaine; Ethanol; Female; Humans; Male; Methadone; Substance Withdrawal Synd | 1996 |
Treatment of pain in chronic bowel subobstruction with self-administration of methadone.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Breast Neoplasms; Chronic Disease; Fatal O | 1997 |
[The experiences of the Munich methadone outpatient clinics].
Topics: Adult; Chronic Disease; Comorbidity; Female; Germany; Heroin Dependence; Humans; Male; Mental Disord | 1997 |
Effects of chronic opioid dependence and HIV-1 infection on pattern shift visual evoked potentials.
Topics: Adult; Analysis of Variance; Case-Control Studies; Chronic Disease; Evoked Potentials, Visual; Femal | 1998 |
The relationship between the visual analog pain intensity and pain relief scale changes during analgesic drug studies in chronic pain patients.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Female; Humans; Hydromorphone; Male; Methadone; Mi | 1999 |
Methadone treatment.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pain; P | 1999 |
Characteristics of methadone maintenance patients with chronic pain.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Female; Humans; Interviews as Topic; Male; Methado | 2000 |
[Nevirapine induces abstinence symptoms in patients on a methadone maintenance program with HIV infection].
Topics: Adult; Analysis of Variance; Anti-HIV Agents; Chronic Disease; Drug Interactions; Drug Therapy, Comb | 2000 |
The merits of methadone.
Topics: Adult; Analgesics, Opioid; Child; Child, Preschool; Chronic Disease; Humans; Methadone; Morphine; Ne | 2000 |
Opioids in chronic non-malignant pain. Don't forget methadone for chronic pain.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain | 2001 |
Successful use of methadone in the treatment of chronic neuropathic pain arising from burn injuries: a case-study.
Topics: Analgesics, Opioid; Burns; Chronic Disease; Humans; Leg Injuries; Male; Methadone; Middle Aged; Neur | 2001 |
Opioid therapy for chronic painful conditions.
Topics: Analgesics, Opioid; Chronic Disease; Clinical Trials as Topic; Fentanyl; Humans; Karnofsky Performan | 2001 |
Drug dependence, parenting responsibilities, and treatment history: why doesn't mom go for help?
Topics: Adult; Child; Chronic Disease; Family; Female; Humans; Marital Status; Methadone; Mothers; Narcotics | 2002 |
Chronic pain: a management plan based on experiences in a pain clinic.
Topics: Behavior Therapy; Carbamazepine; Chronic Disease; Depression; Electric Stimulation Therapy; Humans; | 1979 |
The spectrum and causes of liver diseases in narcotic addicts.
Topics: Acute Disease; Alcoholism; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Chronic Disease; | 1977 |
Psychopathology and mood during heroin use: acute vs chronic effects.
Topics: Acute Disease; Adult; Chronic Disease; Dose-Response Relationship, Drug; Drug Therapy, Combination; | 1976 |
Drug use and distribution in a pain rehabilitation center.
Topics: Adult; Amitriptyline; Barbiturates; Chronic Disease; Diet; Female; Formularies, Hospital as Topic; H | 1975 |
Self-regulated methadone detoxification of heroin addicts. An improved technique in an inpatient setting.
Topics: Adult; Aged; Chronic Disease; Community Participation; Consumer Behavior; Female; Heroin Dependence; | 1975 |
Letter: Drug use in a pain rehabilitation center.
Topics: Amitriptyline; Chronic Disease; Drug Combinations; Humans; Methadone; Pain; Phenytoin; Snake Venoms | 1975 |
Deficits in initial feature registration of schizophrenics and substance abusers.
Topics: Adult; Antipsychotic Agents; Arousal; Attention; Chronic Disease; Discrimination Learning; Female; H | 1992 |
Chronic facial pain together with severe depression is responsive to electroconvulsive therapy. A case report.
Topics: Amitriptyline; Chronic Disease; Clonazepam; Depressive Disorder; Electroconvulsive Therapy; Facial P | 1992 |
Continuous epidural methadone treatment for cancer pain.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Chronic Disease; Female; Humans; Ma | 1991 |
[Study of the motor and sensory neuron conduction velocity and of the H reflex in subjects with chronic opiate poisoning].
Topics: Adult; Chronic Disease; Female; H-Reflex; Heroin Dependence; Humans; Male; Methadone; Motor Neurons; | 1989 |
Medication management in patients with chronic non-malignant pain. A review of the use of a drug withdrawal protocol.
Topics: Analgesics, Opioid; Chronic Disease; Drug Combinations; Humans; Hypnotics and Sedatives; Methadone; | 1986 |
Methadone: pluses and minuses.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; M | 1987 |
Psychoanalytically oriented psychotherapy of substance abuse (with observations on the Penn-VA Study).
Topics: Chronic Disease; Guilt; Hospitals, Veterans; Humans; Methadone; Opioid-Related Disorders; Profession | 1986 |
Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain.
Topics: Adult; Aged; Blood Pressure; Blood Proteins; Chronic Disease; Female; Half-Life; Humans; Kinetics; M | 1987 |
Thyroxine transport and metabolism in methadone and heroin addicts.
Topics: Adult; Biological Transport; Chronic Disease; Female; Humans; Injections, Intravenous; Male; Methado | 1974 |
A 20-year follow-up of New York narcotic addicts.
Topics: Adult; Age Factors; Attitude; Chronic Disease; Ethnicity; Follow-Up Studies; Heroin Dependence; Hosp | 1973 |
Chronic hypercapnia during methadone maintenance.
Topics: Adult; Chronic Disease; Female; Heroin Dependence; Humans; Hypercapnia; Hypoventilation; Male; Metha | 1973 |
Pseudoheroinism.
Topics: Abscess; Chronic Disease; Criminal Psychology; Drug and Narcotic Control; Drug Contamination; Ethics | 1973 |
Editorial: Detoxification of methadone patients, and public policy.
Topics: Chronic Disease; Follow-Up Studies; Humans; Methadone; Politics; Recurrence; Substance Withdrawal Sy | 1973 |
Alcoholism in M.M.T.P. patients: etiological factors and treatment approaches.
Topics: Alcoholism; Chronic Disease; Family Therapy; Heroin Dependence; Humans; Liver Diseases; Methadone; N | 1973 |
Social disease vs disease of society.
Topics: Alcohol Drinking; Alcoholism; Chronic Disease; Humans; Methadone; Social Problems; Substance-Related | 1972 |
Methadone maintenance in hard-core criminal addicts. Economic effects.
Topics: Adult; Chronic Disease; Crime; Economics; Heroin; Humans; Methadone; Middle Aged; Morphine Dependenc | 1971 |
A cyclazocine typology in opiate dependence.
Topics: Adult; Analgesics; Azocines; Chronic Disease; Cyclazocine; Hospitals, General; Humans; Length of Sta | 1970 |
Is narcotic addiction a chronic disease?
Topics: Chronic Disease; Heroin; Humans; Methadone; Substance Withdrawal Syndrome; Substance-Related Disorde | 1966 |