methadone has been researched along with Child Development Deviations in 18 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The drug-dependent women had used combinations of methadone, heroin, cocaine and other drugs during pregnancy." | 3.69 | Development after prenatal exposure to cocaine, heroin and methadone. ( Akkerhuis, GW; Gunning, WB; Soepatmi, S; van Baar, AL, 1994) |
| "This study compares the first year's health, neurodevelopmental status, and environment of infants of drug-dependent mothers attending methadone programs during pregnancy with those of drug-dependent mothers not enrolled in treatment programs (untreated)." | 3.66 | Follow-up of methadone-treated and untreated narcotic-dependent women and their infants: health, developmental, and social implications. ( Desmond, MM; Wait, RB; Wilson, GS, 1981) |
| "Methadone maintenance treatment has definite advantages for the mother and is currently recommended in the UK." | 2.47 | The management of heroin misuse in pregnancy: time for a rethink? ( Mactier, H, 2011) |
| "Although substance use has been a worldwide problem at all levels of society since ancient times, recent attention has been focused on the use of legal and illegal substances by the pregnant woman." | 2.38 | The consequences of prenatal substance use for the developing fetus, newborn, and young child. ( Behnke, M; Eyler, FD, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (33.33) | 18.7374 |
| 1990's | 5 (27.78) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 5 (27.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beckwith, AM | 1 |
| Burke, SA | 1 |
| McGlone, L | 1 |
| Mactier, H | 2 |
| MacKinnon, JR | 1 |
| Sandtorv, L | 1 |
| Reigstad, H | 1 |
| Bruarøy, S | 1 |
| Elgen, I | 1 |
| Laegreid, LM | 1 |
| Walhovd, KB | 1 |
| Watts, R | 1 |
| Amlien, I | 1 |
| Woodward, LJ | 1 |
| Konijnenberg, C | 1 |
| Melinder, A | 1 |
| Logan, BA | 1 |
| Brown, MS | 1 |
| Hayes, MJ | 1 |
| Wilson, GS | 1 |
| Desmond, MM | 1 |
| Wait, RB | 1 |
| Rosen, TS | 2 |
| Johnson, HL | 2 |
| Strauss, ME | 1 |
| Reynolds, KS | 1 |
| Behnke, M | 1 |
| Eyler, FD | 1 |
| Soepatmi, S | 3 |
| van Baar, AL | 2 |
| Gunning, WB | 1 |
| Akkerhuis, GW | 1 |
| de Cubas, MM | 1 |
| Field, T | 1 |
| Nurco, DN | 1 |
| Blatchley, RJ | 1 |
| Hanlon, TE | 1 |
| O'Grady, KE | 1 |
| Fleury, P | 1 |
| Ultee, CA | 1 |
| Wesselman, PJ | 1 |
| Hayford, SM | 1 |
| Epps, RP | 1 |
| Dahl-Regis, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome[NCT02851303] | Phase 4 | 61 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Assessed through chart review of discharge summary documentation of method of infant feeding at time of discharge (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 5 |
| Methadone | 5 |
Number of days in hospital after birth (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | days (Mean) |
|---|---|
| Morphine | 17.9 |
| Methadone | 16.1 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | days (Mean) |
|---|---|
| Morphine | 14.7 |
| Methadone | 12.8 |
clonidine (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 1 |
| Methadone | 0 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 11 |
| Methadone | 6 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 0 |
| Methadone | 3 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | morphine equivalents mg (Mean) |
|---|---|
| Morphine | 9.86 |
| Methadone | 33.0 |
5 reviews available for methadone and Child Development Deviations
| Article | Year |
|---|---|
The management of heroin misuse in pregnancy: time for a rethink?
Topics: Buprenorphine; Child, Preschool; Developmental Disabilities; Female; Heroin Dependence; Humans; Infa | 2011 |
Neonatal abstinence syndrome: treatment and pediatric outcomes.
Topics: Developmental Disabilities; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonatal Abstinen | 2013 |
Psychological characteristics and development of narcotic-addicted infants.
Topics: Child Behavior Disorders; Developmental Disabilities; Heroin; Humans; Infant, Newborn; Infant, Newbo | 1983 |
The consequences of prenatal substance use for the developing fetus, newborn, and young child.
Topics: Cannabis; Child; Child, Preschool; Congenital Abnormalities; Developmental Disabilities; Female; Hea | 1993 |
Behavior and development patterns in children born to heroin-addicted and methadone-addicted mothers.
Topics: Child; Child Behavior Disorders; Child, Preschool; Developmental Disabilities; Female; Heroin; Human | 1988 |
13 other studies available for methadone and Child Development Deviations
| Article | Year |
|---|---|
Identification of early developmental deficits in infants with prenatal heroin, methadone, and other opioid exposure.
Topics: Analgesics, Opioid; Child Development; Developmental Disabilities; Female; Heroin; Humans; Infant; I | 2015 |
Outcome in infants exposed to methadone in utero.
Topics: Developmental Disabilities; Female; Humans; Infant; Infant, Newborn; Methadone; Narcotics; Pregnancy | 2008 |
[Substitution treatment of drug addicts during pregnancy: consequences for the children?].
Topics: Buprenorphine; Developmental Disabilities; Female; Humans; Infant, Newborn; Methadone; Narcotics; Ne | 2009 |
Neural tract development of infants born to methadone-maintained mothers.
Topics: Analgesics, Opioid; Brain; Brain Mapping; Developmental Disabilities; Diffusion Tensor Imaging; Fema | 2012 |
Neurodevelopmental investigation of the mirror neurone system in children of women receiving opioid maintenance therapy during pregnancy.
Topics: Adult; Analysis of Variance; Buprenorphine; Case-Control Studies; Child, Preschool; Developmental Di | 2013 |
Follow-up of methadone-treated and untreated narcotic-dependent women and their infants: health, developmental, and social implications.
Topics: Adult; Developmental Disabilities; Female; Follow-Up Studies; Health Status; Humans; Infant; Infant, | 1981 |
Children of methadone-maintained mothers: follow-up to 18 months of age.
Topics: Abnormalities, Drug-Induced; Developmental Disabilities; Female; Follow-Up Studies; Humans; Infant; | 1982 |
Developmental outcomes of children of mothers dependent on heroin or heroin/methadone during pregnancy.
Topics: Child; Child of Impaired Parents; Child, Preschool; Cross-Sectional Studies; Developmental Disabilit | 1994 |
Development after prenatal exposure to cocaine, heroin and methadone.
Topics: Case-Control Studies; Child; Child of Impaired Parents; Child, Preschool; Cocaine; Developmental Dis | 1994 |
Children of methadone-dependent women: developmental outcomes.
Topics: Affective Symptoms; Child; Child Behavior Disorders; Child, Preschool; Developmental Disabilities; E | 1993 |
Early deviance and related risk factors in the children of narcotic addicts.
Topics: Adolescent; Adult; Alcoholism; Child; Child Behavior Disorders; Child of Impaired Parents; Developme | 1999 |
Drug-addicted mothers, their infants, and SIDS.
Topics: Adult; Alcohol Drinking; Cocaine; Developmental Disabilities; Female; Heroin Dependence; Humans; Inf | 1988 |
Neonatal behavior after drug dependent pregnancy.
Topics: Child; Child Behavior; Child, Preschool; Developmental Disabilities; Electroencephalography; Female; | 1989 |