methadone has been researched along with Cardiotoxicity in 6 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Cardiotoxicity: Damage to the HEART or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As methadone use increases, the potential for methadone-induced cardiotoxicity (MIC) may rise." | 7.96 | Acute right ventricular failure: a novel presentation of methadone-induced cardiotoxicity. ( Ahmed, MM; Al-Ani, M; Dasa, O; Radhakrishnan, NS; Taha, MB; Taha, OB, 2020) |
| " Chemical specific adjustment factors were defined and used to derive dose-response curves for the sensitive individuals." | 5.72 | In vitro-in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans. ( Bouwmeester, H; Dong, Y; Rietjens, IMCM; Shi, M; Strikwold, M, 2022) |
| "Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing." | 5.56 | Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone. ( Bouwmeester, H; Rietjens, IMCM; Shi, M; Strikwold, M, 2020) |
| "As methadone use increases, the potential for methadone-induced cardiotoxicity (MIC) may rise." | 3.96 | Acute right ventricular failure: a novel presentation of methadone-induced cardiotoxicity. ( Ahmed, MM; Al-Ani, M; Dasa, O; Radhakrishnan, NS; Taha, MB; Taha, OB, 2020) |
| " Chemical specific adjustment factors were defined and used to derive dose-response curves for the sensitive individuals." | 1.72 | In vitro-in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans. ( Bouwmeester, H; Dong, Y; Rietjens, IMCM; Shi, M; Strikwold, M, 2022) |
| "Development of novel testing strategies to detect adverse human health effects is of interest to replace in vivo-based drug and chemical safety testing." | 1.56 | Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone. ( Bouwmeester, H; Rietjens, IMCM; Shi, M; Strikwold, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 4 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, M | 2 |
| Dong, Y | 1 |
| Bouwmeester, H | 2 |
| Rietjens, IMCM | 2 |
| Strikwold, M | 2 |
| Taha, MB | 1 |
| Dasa, O | 1 |
| Al-Ani, M | 1 |
| Taha, OB | 1 |
| Radhakrishnan, NS | 1 |
| Ahmed, MM | 1 |
| Krantz, MJ | 1 |
| Palmer, RB | 1 |
| Haigney, MCP | 1 |
| Sheibani, M | 1 |
| Zamani, N | 1 |
| Hassanian-Moghaddam, H | 1 |
| Lusetti, M | 1 |
| Licata, M | 1 |
| Silingardi, E | 1 |
| Reggiani Bonetti, L | 1 |
| Palmiere, C | 1 |
1 review available for methadone and Cardiotoxicity
| Article | Year |
|---|---|
Cardiovascular Complications of Opioid Use: JACC State-of-the-Art Review.
Topics: Analgesics, Opioid; Cardiotoxicity; Cardiovascular Diseases; Humans; Methadone; Opioid-Related Disor | 2021 |
5 other studies available for methadone and Cardiotoxicity
| Article | Year |
|---|---|
In vitro-in silico-based prediction of inter-individual and inter-ethnic variations in the dose-dependent cardiotoxicity of R- and S-methadone in humans.
Topics: Cardiotoxicity; Cytochrome P-450 Enzyme System; Humans; Kinetics; Methadone; Microsomes, Liver; Mode | 2022 |
Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone.
Topics: Action Potentials; Analgesics, Opioid; Arrhythmias, Cardiac; Cardiotoxicity; Cell Line; Computer Sim | 2020 |
Acute right ventricular failure: a novel presentation of methadone-induced cardiotoxicity.
Topics: Acute Disease; Antitussive Agents; Cardiotoxicity; Drug Overdose; Female; Heart Failure; Humans; Met | 2020 |
Electrocardiographic Findings in Mortalities Due to Pure Methadone Toxicity.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Arrhythmias, Cardiac; Cardiotoxicity; Cause of Death; C | 2019 |
Therapeutic and recreational methadone cardiotoxicity.
Topics: Adult; Cardiotoxicity; Death, Sudden, Cardiac; Forensic Toxicology; Humans; Male; Methadone; Myocard | 2016 |