methadone has been researched along with Cardiac Arrest, Sudden in 19 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain." | 8.86 | Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010) |
| "Nearly 20 studies showed a prolonged QT interval secondary to methadone in patients exhibiting the following features: (1) patients with cardiac pathologies, notably bradycardia, congenital long QT interval, myocardial pathologies related to AIDS and electrolyte disturbances; (2) patients receiving concomitant treatment with substances known to prolong QT interval, such as psychoactive stimulants, narcoleptics, tricyclic antidepressants, antiarrhythmic agents, macrolids, quinolones, non diuretic hypokalemiants and certain corticoids; (3) patients receiving treatments that inhibit methadone's metabolism, particularly those that act on the cytochrome P450 3A4 such as SSRI, antifungal agents, some macrolids and some retroviral agents." | 4.88 | [Review of cases of prolonged QTC and wave burst arrhythmia in patients treated with methadone]. ( Berleur, MP; Kerbage, H; Laqueille, X; Richa, S; Scart-Gres, C, 2012) |
| "Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain." | 4.86 | Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010) |
| "Sudden cardiac death was recorded in five patients, and torsade de pointes was recorded in seven other patients." | 1.39 | Drug-induced long QT in adult psychiatric inpatients: the 5-year cross-sectional ECG Screening Outcome in Psychiatry study. ( Berney, P; Dayer, P; Gaspoz, JM; Gex-Fabry, M; Girardin, FR; Shah, D, 2013) |
| "In this study, a case of sudden cardiac arrest in a patient on chronic methadone therapy is presented." | 1.39 | Sudden cardiac arrest in a patient on chronic methadone after the addition of azithromycin. ( Twilla, JD; Winton, JC, 2013) |
| "A total of 22 sudden cardiac death cases with therapeutic levels of methadone (mean 0." | 1.35 | A community-based evaluation of sudden death associated with therapeutic levels of methadone. ( Chugh, SS; Gunson, K; Jui, J; Reinier, K; Socoteanu, C; Waltz, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (52.63) | 29.6817 |
| 2010's | 9 (47.37) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Upadhya, B | 1 |
| Ntim, W | 1 |
| Brandon Stacey, R | 1 |
| Henderson, R | 1 |
| Leedy, D | 1 |
| O'Brien, FX | 1 |
| Knovich, MA | 1 |
| Girardin, FR | 1 |
| Gex-Fabry, M | 1 |
| Berney, P | 1 |
| Shah, D | 1 |
| Gaspoz, JM | 1 |
| Dayer, P | 1 |
| Lusetti, M | 1 |
| Licata, M | 1 |
| Silingardi, E | 1 |
| Reggiani Bonetti, L | 1 |
| Palmiere, C | 1 |
| Acciavatti, T | 1 |
| Martinotti, G | 1 |
| Corbo, M | 1 |
| Cinosi, E | 1 |
| Lupi, M | 1 |
| Ricci, F | 1 |
| Di Scala, R | 1 |
| D'Ugo, E | 1 |
| De Francesco, V | 1 |
| De Caterina, R | 1 |
| di Giannantonio, M | 1 |
| Kim, HK | 1 |
| Manini, A | 1 |
| Behr, ER | 1 |
| Camm, AJ | 1 |
| Modesto-Lowe, V | 1 |
| Brooks, D | 1 |
| Petry, N | 1 |
| Perrin-Terrin, A | 1 |
| Pathak, A | 1 |
| Lapeyre-Mestre, M | 1 |
| Karch, SB | 1 |
| Laqueille, X | 1 |
| Richa, S | 1 |
| Kerbage, H | 1 |
| Scart-Gres, C | 1 |
| Berleur, MP | 1 |
| Winton, JC | 1 |
| Twilla, JD | 1 |
| Stimmel, B | 2 |
| Harris, JD | 1 |
| de Leon-Casasola, OA | 1 |
| Andersen, HT | 1 |
| Ekgren, JS | 1 |
| Byrne, A | 1 |
| Waal, H | 1 |
| Krook, AL | 1 |
| Hansteen, V | 1 |
| Ehret, GB | 1 |
| Desmeules, JA | 1 |
| Broers, B | 1 |
| Chugh, SS | 1 |
| Socoteanu, C | 1 |
| Reinier, K | 1 |
| Waltz, J | 1 |
| Jui, J | 1 |
| Gunson, K | 1 |
| Junttila, MJ | 1 |
| Gonzalez, M | 1 |
| Lizotte, E | 1 |
| Benito, B | 1 |
| Vernooy, K | 1 |
| Sarkozy, A | 1 |
| Huikuri, HV | 1 |
| Brugada, P | 1 |
| Brugada, J | 1 |
| Brugada, R | 1 |
4 reviews available for methadone and Cardiac Arrest, Sudden
| Article | Year |
|---|---|
Methadone deaths: risk factors in pain and addicted populations.
Topics: Analgesics, Opioid; Chronic Disease; Death, Sudden, Cardiac; Drug Overdose; Humans; Methadone; Opiat | 2010 |
[Review of cases of prolonged QTC and wave burst arrhythmia in patients treated with methadone].
Topics: Adult; Analgesics, Opioid; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug Interactio | 2012 |
Methadone-associated long QT syndrome: improving pharmacotherapy for dependence on illegal opioids and lessons learned for pharmacology.
Topics: Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Electr | 2007 |
Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias.
Topics: Adult; Age of Onset; Anesthetics; Antidepressive Agents, Tricyclic; Brugada Syndrome; Cocaine; Death | 2008 |
1 trial available for methadone and Cardiac Arrest, Sudden
| Article | Year |
|---|---|
QT interval prolongation: prevalence, risk factors and pharmacovigilance data among methadone-treated patients in France.
Topics: Adult; Death, Sudden; Death, Sudden, Cardiac; Female; France; Heart Diseases; Humans; Long QT Syndro | 2011 |
14 other studies available for methadone and Cardiac Arrest, Sudden
| Article | Year |
|---|---|
Prolongation of QTc intervals and risk of death among patients with sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Death, Sudden, Cardiac; Echocardiography; Electrocardiography; Female; F | 2013 |
Drug-induced long QT in adult psychiatric inpatients: the 5-year cross-sectional ECG Screening Outcome in Psychiatry study.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Case-Control Studies; Citalopram; Cross-Sectional Stu | 2013 |
Therapeutic and recreational methadone cardiotoxicity.
Topics: Adult; Cardiotoxicity; Death, Sudden, Cardiac; Forensic Toxicology; Humans; Male; Methadone; Myocard | 2016 |
Psychotropic drugs and ventricular repolarisation: The effects on QT interval, T-peak to T-end interval and QT dispersion.
Topics: Cross-Sectional Studies; Death, Sudden, Cardiac; Electrocardiography; Female; Heart Ventricles; Huma | 2017 |
Methadone-associated sudden cardiac death?
Topics: Adult; Analgesics, Opioid; Autopsy; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug O | 2008 |
Letter by Behr and Camm regarding article, "Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias".
Topics: Adult; Age of Onset; Anesthetics; Antidepressive Agents, Tricyclic; Brugada Syndrome; Cocaine; Death | 2008 |
Is it time to reformulate racemic methadone?
Topics: Adult; Arrhythmias, Cardiac; Chemistry, Pharmaceutical; Chronic Disease; Death, Sudden, Cardiac; Fem | 2011 |
Sudden cardiac arrest in a patient on chronic methadone after the addition of azithromycin.
Topics: Azithromycin; Death, Sudden, Cardiac; Drug Therapy, Combination; Heart Arrest; Humans; Male; Methado | 2013 |
Methadone and affairs of the heart and of the brain.
Topics: Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Electrocardiography; Humans; Long QT Syndr | 2003 |
Oral erythromycin and the risk of sudden death.
Topics: Anti-Bacterial Agents; Cytochrome P-450 Enzyme Inhibitors; Death, Sudden, Cardiac; Drug Interactions | 2005 |
[Heart arrhythmia and sudden death during methadone therapy].
Topics: Death, Sudden; Death, Sudden, Cardiac; Humans; Long QT Syndrome; Methadone; Narcotics; Opioid-Relate | 2007 |
Methadone and QTc prolongation.
Topics: Analgesics, Opioid; Death, Sudden, Cardiac; Drug Interactions; Electrocardiography; Heroin Dependenc | 2007 |
[Methadone treatment and heart arrhythmia].
Topics: Death, Sudden; Death, Sudden, Cardiac; Humans; Long QT Syndrome; Methadone; Narcotics | 2007 |
A community-based evaluation of sudden death associated with therapeutic levels of methadone.
Topics: Adult; Analgesics, Opioid; Autopsy; Death, Sudden, Cardiac; Dose-Response Relationship, Drug; Drug O | 2008 |