methadone has been researched along with Cancer of Head in 12 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is the first study to show noninferiority of methadone compared to fentanyl at 1 and 3 weeks in the treatment of radiation-induced nociceptive pain in patients with head and neck cancer." | 9.27 | Methadone versus Fentanyl in Patients with Radiation-Induced Nociceptive Pain with Head and Neck Cancer: A Randomized Controlled Noninferiority Trial. ( Geurts, JW; Haumann, J; Hoebers, FJP; Joosten, EA; Kremer, B; van den Beuken-van Everdingen, MHJ; van Kuijk, SMJ, 2018) |
| "We evaluated the analgesia, tolerability and absorption profile of methadone hydrochloride in six opioid-naive cancer patients with pain." | 7.69 | Rectal methadone in cancer patients with pain. A preliminary clinical and pharmacokinetic study. ( Brunelli, C; De Conno, F; Lodi, F; Ripamonti, C; Rizzio, E; Saita, L; Zecca, E, 1995) |
| "This is the first study to show noninferiority of methadone compared to fentanyl at 1 and 3 weeks in the treatment of radiation-induced nociceptive pain in patients with head and neck cancer." | 5.27 | Methadone versus Fentanyl in Patients with Radiation-Induced Nociceptive Pain with Head and Neck Cancer: A Randomized Controlled Noninferiority Trial. ( Geurts, JW; Haumann, J; Hoebers, FJP; Joosten, EA; Kremer, B; van den Beuken-van Everdingen, MHJ; van Kuijk, SMJ, 2018) |
| "We evaluated the analgesia, tolerability and absorption profile of methadone hydrochloride in six opioid-naive cancer patients with pain." | 3.69 | Rectal methadone in cancer patients with pain. A preliminary clinical and pharmacokinetic study. ( Brunelli, C; De Conno, F; Lodi, F; Ripamonti, C; Rizzio, E; Saita, L; Zecca, E, 1995) |
| "Cancer pain is still inadequately treated in up to 60% of cancer patients." | 2.82 | Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer. ( Geurts, JW; Haumann, J; Joosten, EA; Kremer, B; van den Beuken-van Everdingen, MH; van Kuijk, SM, 2016) |
| "Methadone is a unique opioid with several special properties besides being a mu agonist, which makes for difficulty in the calculation of equianalgesic doses." | 1.31 | Methadone as a rescue for failed high-dose opiate therapy for catastrophic pain. ( Davis, MP, 2000) |
| "Twenty patients with end-stage head and neck cancer, unresponsive to either acetaminophen with codeine or oxycodone hydrochloride, were placed on a four-drug analgesic regimen consisting of methadone hydrochloride, Trilisate or acetaminophen, a tricyclic antidepressant, and, in most cases, hydroxyzine." | 1.29 | A four-drug pain regimen for head and neck cancers. ( Carrol, EN; Fine, E; Ruff, RL; Stepnick, D, 1994) |
| "If pain is in the trigeminal nerve distribution, local nerve block procedures may provide additional relief." | 1.26 | Pain control in advanced and recurrent head and neck cancer. ( McCann, CF; Scott, RM; Shapshay, SM; Stoelting, I, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Matsuda, Y | 1 |
| Okayama, S | 1 |
| Haumann, J | 3 |
| van Kuijk, SMJ | 1 |
| Geurts, JW | 3 |
| Hoebers, FJP | 1 |
| Kremer, B | 3 |
| Joosten, EA | 3 |
| van den Beuken-van Everdingen, MHJ | 1 |
| Landgraf, V | 1 |
| Griessmann, M | 1 |
| Roller, J | 1 |
| Polednik, C | 1 |
| Schmidt, M | 1 |
| van Kuijk, SM | 2 |
| van den Beuken-van Everdingen, MH | 2 |
| Ruan, X | 1 |
| Luo, JJ | 1 |
| Kaye, AD | 1 |
| Connolly, I | 1 |
| Zaleon, C | 1 |
| Montagnini, M | 1 |
| Shapshay, SM | 1 |
| Scott, RM | 1 |
| McCann, CF | 1 |
| Stoelting, I | 1 |
| Carrol, EN | 1 |
| Fine, E | 1 |
| Ruff, RL | 1 |
| Stepnick, D | 1 |
| Ripamonti, C | 1 |
| Zecca, E | 1 |
| Brunelli, C | 1 |
| Rizzio, E | 1 |
| Saita, L | 1 |
| Lodi, F | 1 |
| De Conno, F | 1 |
| Davis, MP | 1 |
| Mullan, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methadone for 'Adenocarcinopathic' Pain Treatment: Methadone vs. Morphine Vanguard RCT[NCT05325164] | Phase 3 | 0 participants (Actual) | Interventional | 2022-09-30 | Withdrawn (stopped due to Trial not started; change in Sponsor and Principal Investigator, trial to be registered again by new Sponsor/Investigator if it is started.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for methadone and Cancer of Head
| Article | Year |
|---|---|
Management of severe neuropathic cancer pain: an illustrative case and review.
Topics: Aged; Analgesics, Opioid; Anticonvulsants; Drug Therapy, Combination; Head and Neck Neoplasms; Human | 2013 |
2 trials available for methadone and Cancer of Head
| Article | Year |
|---|---|
Methadone versus Fentanyl in Patients with Radiation-Induced Nociceptive Pain with Head and Neck Cancer: A Randomized Controlled Noninferiority Trial.
Topics: Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Head and Neck Neoplasms; Humans; Male; Methadone; | 2018 |
Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
Topics: Adult; Aged; Analgesics, Opioid; Cancer Pain; Female; Fentanyl; Head and Neck Neoplasms; Humans; Mal | 2016 |
9 other studies available for methadone and Cancer of Head
| Article | Year |
|---|---|
Oral Methadone for Patients With Neuropathic Pain Due to Neoplastic Brachial Plexopathy.
Topics: Analgesics, Opioid; Brachial Plexus Neuropathies; Head and Neck Neoplasms; Humans; Methadone; Neural | 2022 |
DL-Methadone as an Enhancer of Chemotherapeutic Drugs in Head and Neck Cancer Cell Lines.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transpor | 2019 |
Letter response: Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
Topics: Analgesics, Opioid; Fentanyl; Head and Neck Neoplasms; Humans; Methadone; Neuralgia; Pain; Pain Meas | 2016 |
Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
Topics: Analgesics, Opioid; Fentanyl; Head and Neck Neoplasms; Humans; Methadone; Neoplasms; Neuralgia; Pain | 2016 |
Pain control in advanced and recurrent head and neck cancer.
Topics: Dextroamphetamine; Drug Therapy, Combination; Electrocoagulation; Head and Neck Neoplasms; Humans; M | 1980 |
A four-drug pain regimen for head and neck cancers.
Topics: Acetaminophen; Adult; Aged; Antidepressive Agents, Tricyclic; Drug Administration Schedule; Drug The | 1994 |
Rectal methadone in cancer patients with pain. A preliminary clinical and pharmacokinetic study.
Topics: Administration, Rectal; Adult; Analgesics, Opioid; Colorectal Neoplasms; Female; Head and Neck Neopl | 1995 |
Methadone as a rescue for failed high-dose opiate therapy for catastrophic pain.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Breast Neoplasms; Carcinoma, Squamous Cell; Female; | 2000 |
Surgical management of pain in cancer of the head and neck.
Topics: Alcohols; Autonomic Nerve Block; Carbamazepine; Chlorpromazine; Cranial Nerves; Gastrostomy; Head; H | 1973 |