methadone has been researched along with Cancer-Associated Pain in 56 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intravenous methadone may be useful in acute and chronic pain management compared with other opioids because of its pharmacokinetic and pharmacodynamic characteristics, including the long duration of effect and ability to modulate both pain stimuli propagation and analgesic descending pathways." | 9.41 | Intravenous Methadone for Perioperative and Chronic Cancer Pain: A Review of the Literature. ( Mercadante, S, 2023) |
| " Studies were included if methadone was a first-line drug as a Step 3 of World Health Organization analgesic ladder, or at low doses (Step 2), if they were conducted in adult patients with cancer pain, and if they contained outcomes on pain- and opioid-related adverse effects." | 8.98 | Methadone as a First-Line Opioid in Cancer Pain Management: A Systematic Review. ( Bruera, E; Mercadante, S, 2018) |
| "Methadone is an effective, safe, and cost-saving treatment for patients with refractory cancer pain." | 8.12 | Methadone switching for refractory cancer pain. ( Ding, H; Fang, L; Gong, L; He, C; Song, Y; Sun, J; Xin, W; Zhong, L; Zhou, Q, 2022) |
| "A retrospective review of 52 inpatients initiated on methadone for cancer pain from June 2015 to June 2018 was conducted." | 8.12 | Methadone rotation for cancer pain: an observational study. ( Hum, A; Tan, C; Wong, JF; Yee, CM, 2022) |
| "It was suggested that D, L-Methadone might improve the clinical course of glioma patients." | 8.02 | Safety aspects of opioid-naïve patients with high-grade glioma treated with D,L-Methadone: an observational case series. ( Bettag, C; Rohde, V; Schatlo, B; von der Brelie, C, 2021) |
| "Although methadone has the potential to improve the management of cancer pain, it has some serious problems, such as respiratory depression and QT interval prolongation." | 8.02 | Assistance of a Palliative Care Certified Nurse in the Alleviation of Refractory Cancer Pain by Switching Opioids to Oral Methadone in a Japanese Outpatient Setting. ( Matsuda, Y; Okayama, S, 2021) |
| "To describe the titration phase of the treatment with low-dose first-line methadone and the use of methadone for breakthrough pain." | 8.02 | First-line methadone for cancer pain: titration time analysis. ( Armesto, A; Bertolino, M; Bruera, E; Bunge, S; Dran, G; Mammana, G; Orellana, F; Peirano, G; Vega, F, 2021) |
| "The use of methadone for cancer pain is limited by the need of expertise and close titration due to variable half-life." | 7.83 | Methadone as first-line opioid treatment for cancer pain in a developing country palliative care unit. ( Armesto, A; Bertolino, MS; Camerano, G; Dran, G; Mammana, GP; Pastrana, T; Peirano, GP; Ruggiero, R; Russo, J; Varela, G; Vega, GF; Vignaroli, E, 2016) |
| "The risk of hypoglycemia is increased for patients taking more than 40 mg oral methadone equivalents per day." | 7.83 | Methadone Use and the Risk of Hypoglycemia for Inpatients With Cancer Pain. ( Flory, JH; Koranteng, L; Moryl, N; Thaler, HT; Wiesenthal, AC, 2016) |
| "In outpatients with advanced cancer, rotation to methadone as a second-line opioid was efficacious and safe when using a tiered scheme with close follow-up by experienced health professionals." | 6.82 | Efficacy and Safety of Methadone as a Second-Line Opioid for Cancer Pain in an Outpatient Clinic: A Prospective Open-Label Study. ( Garzón-Rodríguez, C; González-Barboteo, J; Llorens-Torromé, S; Porta-Sales, J; Villavicencio-Chávez, C, 2016) |
| "Patients with advanced cancer were prospectively assessed." | 5.72 | Methadone as First-line Opioid for the Management of Cancer Pain. ( Adile, C; Bonanno, G; Casuccio, A; Ferrera, P; Mercadante, S; Pallotti, MC; Ricci, M, 2022) |
| "In patients with pediatric cancer who are nearing the end of life, methadone is a valuable adjunctive therapy to treat nociceptive and neuropathic pain and to prevent opioid-induced hyperalgesia and opioid tolerance." | 5.62 | Methadone for Cancer Pain in Pediatric End-of-Life Care. ( Anghelescu, DL; Habashy, C; Hall, EA; Sauer, HE, 2021) |
| "Methadone can cause a prolonged QTc interval that can lead to ventricular arrhythmias." | 5.46 | The frequency of QTc prolongation among pediatric and young adult patients receiving methadone for cancer pain. ( Bruera, E; Liu, D; Madden, K; Park, M, 2017) |
| "Intravenous methadone may be useful in acute and chronic pain management compared with other opioids because of its pharmacokinetic and pharmacodynamic characteristics, including the long duration of effect and ability to modulate both pain stimuli propagation and analgesic descending pathways." | 5.41 | Intravenous Methadone for Perioperative and Chronic Cancer Pain: A Review of the Literature. ( Mercadante, S, 2023) |
| "In the European Association for Palliative Care recommendations for cancer pain management, there was no consensus regarding the indications, titration, or monitoring of methadone." | 5.22 | Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer-Related Pain: The EQUIMETH2 Trial (Methadone for Cancer-Related Pain). ( Berleur, MP; Chvetzoff, G; Derniaux, A; Filbet, M; Lefebvre, D; Lefki, S; Poulain, P; Serra, E; Tremellat, F, 2016) |
| " A group of experts nominated by the 3 French Societies involved in the treatment of cancer pain (AFSOS, SFAP, SFETD), established new guidelines ratios for morphine switching and/or changing of route of administration, in patients for whom either pain was not adequatly managed or adverse effects were unbearable." | 4.98 | [Opioid switch and change of route of administration in cancer patients treated by morphine]. ( Ammar, D; Baron, L; Chvetzoff, G; Collin, E; Delorme, C; Delorme, T; Faure, S; Filbet, M; Hubault, P; Jovenin, N; Krakowski, I; Magnet, M; Michenot, N; Minello, C; Poulain, P; Rostaing, S, 2018) |
| " Studies were included if methadone was a first-line drug as a Step 3 of World Health Organization analgesic ladder, or at low doses (Step 2), if they were conducted in adult patients with cancer pain, and if they contained outcomes on pain- and opioid-related adverse effects." | 4.98 | Methadone as a First-Line Opioid in Cancer Pain Management: A Systematic Review. ( Bruera, E; Mercadante, S, 2018) |
| "In our article ?Methadone switching for refractory cancer pain' (BMC palliative care, 2022) we explore the efficacy, safety and economics of methadone in treatment of patients with refractory cancer pain in China." | 4.31 | Reply to "A better interpretation of data regarding the opioid switching to methadone". ( Ding, H; Fang, L; Gong, L; He, C; Song, Y; Sun, J; Xin, W; Zhong, L; Zhou, Q, 2023) |
| "Methadone is an effective, safe, and cost-saving treatment for patients with refractory cancer pain." | 4.12 | Methadone switching for refractory cancer pain. ( Ding, H; Fang, L; Gong, L; He, C; Song, Y; Sun, J; Xin, W; Zhong, L; Zhou, Q, 2022) |
| "A retrospective review of 52 inpatients initiated on methadone for cancer pain from June 2015 to June 2018 was conducted." | 4.12 | Methadone rotation for cancer pain: an observational study. ( Hum, A; Tan, C; Wong, JF; Yee, CM, 2022) |
| "It was suggested that D, L-Methadone might improve the clinical course of glioma patients." | 4.02 | Safety aspects of opioid-naïve patients with high-grade glioma treated with D,L-Methadone: an observational case series. ( Bettag, C; Rohde, V; Schatlo, B; von der Brelie, C, 2021) |
| "To describe the titration phase of the treatment with low-dose first-line methadone and the use of methadone for breakthrough pain." | 4.02 | First-line methadone for cancer pain: titration time analysis. ( Armesto, A; Bertolino, M; Bruera, E; Bunge, S; Dran, G; Mammana, G; Orellana, F; Peirano, G; Vega, F, 2021) |
| "Although methadone has the potential to improve the management of cancer pain, it has some serious problems, such as respiratory depression and QT interval prolongation." | 4.02 | Assistance of a Palliative Care Certified Nurse in the Alleviation of Refractory Cancer Pain by Switching Opioids to Oral Methadone in a Japanese Outpatient Setting. ( Matsuda, Y; Okayama, S, 2021) |
| "Despite being associated with dependence and social stigma, methadone is a potential end-of-life option in complex cancer pain." | 3.96 | Methadone in Swedish specialized palliative care-Is it the magic bullet in complex cancer-related pain? ( Fürst, P; Lundström, S; Strang, P, 2020) |
| "Our study examined the frequency of QTc prolongation among pediatric and young adult patients starting methadone for cancer pain." | 3.91 | Corrected QT Interval Prolongation in Pediatric and Young Adult Patients on Methadone for Cancer-Related Pain. ( Bruera, E; Jo, E; Liu, D; Madden, K; Williams, JL, 2019) |
| "The effect of methadone on corrected QT interval (QTc) in patients with cancer pain is not well-known." | 3.91 | Evaluation of QTc Interval Prolongation Among Patients With Cancer Using Enteral Methadone. ( Hartman, A; Kale, SS; Lehman, A; Lovell, AG; Protus, BM; Saphire, ML, 2019) |
| "Methadone has been shown to be effective for cancer pain." | 3.85 | Clinical Outcomes of Start-Low, Go-Slow Methadone Initiation for Cancer-Related Pain: What's the Hurry? ( Chow, L; Fyles, G; Hawley, P; Mittelstadt, M; O'Leary, MJ; Shokoohi, A, 2017) |
| "The risk of hypoglycemia is increased for patients taking more than 40 mg oral methadone equivalents per day." | 3.83 | Methadone Use and the Risk of Hypoglycemia for Inpatients With Cancer Pain. ( Flory, JH; Koranteng, L; Moryl, N; Thaler, HT; Wiesenthal, AC, 2016) |
| "The use of methadone for cancer pain is limited by the need of expertise and close titration due to variable half-life." | 3.83 | Methadone as first-line opioid treatment for cancer pain in a developing country palliative care unit. ( Armesto, A; Bertolino, MS; Camerano, G; Dran, G; Mammana, GP; Pastrana, T; Peirano, GP; Ruggiero, R; Russo, J; Varela, G; Vega, GF; Vignaroli, E, 2016) |
| "A sample if 41 patients with cancer-related pain in palliative setting were included." | 3.01 | A Randomized Controlled Trial Evaluating the Analgesic Effect of the Combination of Methadone With Morphine for Cancer Related Pain. ( Duarte, FCN; Ferraro, LHDC; Ferreira, A; Sakata, RK, 2021) |
| "In outpatients with advanced cancer, rotation to methadone as a second-line opioid was efficacious and safe when using a tiered scheme with close follow-up by experienced health professionals." | 2.82 | Efficacy and Safety of Methadone as a Second-Line Opioid for Cancer Pain in an Outpatient Clinic: A Prospective Open-Label Study. ( Garzón-Rodríguez, C; González-Barboteo, J; Llorens-Torromé, S; Porta-Sales, J; Villavicencio-Chávez, C, 2016) |
| "Cancer pain is still inadequately treated in up to 60% of cancer patients." | 2.82 | Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer. ( Geurts, JW; Haumann, J; Joosten, EA; Kremer, B; van den Beuken-van Everdingen, MH; van Kuijk, SM, 2016) |
| "Methadone has a unique mechanism of action when compared with all other opioids and for this reason methadone has come to hold a niche role in the management of opioid-induced hyperalgesia and central sensitization." | 2.66 | Methadone for Pain Management: A Pharmacotherapeutic Review. ( Kreutzwiser, D; Tawfic, QA, 2020) |
| "Methadone continues to be an important medication for the treatment of paediatric and adult cancer-related pain." | 2.66 | Emerging Challenges to the Safe and Effective Use of Methadone for Cancer-Related Pain in Paediatric and Adult Patient Populations. ( Ajayi, TA; Atayee, RS; Edmonds, KP; Saunders, IM; Willeford, A, 2020) |
| "Methadone is a synthetic opioid with unique pharmacodynamic and pharmacokinetic properties." | 2.58 | Methadone for Pain Management in Children with Cancer. ( Anghelescu, DL; Habashy, C; Hall, EA; Springer, E, 2018) |
| "Patients with advanced cancer were prospectively assessed." | 1.72 | Methadone as First-line Opioid for the Management of Cancer Pain. ( Adile, C; Bonanno, G; Casuccio, A; Ferrera, P; Mercadante, S; Pallotti, MC; Ricci, M, 2022) |
| "Opioid misuse and opioid use disorder (OUD) are important comorbidities in people with advanced cancer and cancer-related pain, but there is a lack of consensus on treatment." | 1.72 | Consensus-Based Guidance on Opioid Management in Individuals With Advanced Cancer-Related Pain and Opioid Misuse or Use Disorder. ( Arnold, R; Bulls, H; Dao, E; Fitzgerald Jones, K; Kapo, J; Khodyakov, D; Liebschutz, J; Meier, D; Merlin, J; Paice, J; Ritchie, C, 2022) |
| "In patients with pediatric cancer who are nearing the end of life, methadone is a valuable adjunctive therapy to treat nociceptive and neuropathic pain and to prevent opioid-induced hyperalgesia and opioid tolerance." | 1.62 | Methadone for Cancer Pain in Pediatric End-of-Life Care. ( Anghelescu, DL; Habashy, C; Hall, EA; Sauer, HE, 2021) |
| "MR for CIBP may result in reduction in pain intensity, when other opioids are ineffective or intolerable, with patients requiring reduced overall dosing of their long-acting opioid and frequency of breakthrough opioid use." | 1.62 | The role of methadone in cancer-induced bone pain: a retrospective cohort study. ( Al-Rubaie, Z; Key, S; Kwok, J; Michael, N; Sulistio, M; Wojnar, R, 2021) |
| "Opioids are the first-line treatment for cancer pain." | 1.62 | Antinociceptive synergism upon the joint use of methadone and Phα1β in a model of cancer-related pain in C57BL/6J mice. ( Aoki, CT; Castro Junior, CJ; Delgado, MA; Ferreira, J; Ferreira, LA; Gomez, MV; Mendes, MP; Moura, RA; Rezende, MJ; Santos, DC, 2021) |
| "All study participants reported cancer pain with neuropathic components; most had mixed pain syndromes comprising nociceptive and neuropathic components." | 1.62 | Combination therapy with methadone and duloxetine for cancer-related pain: a retrospective study. ( Abdullaziz, S; Curry, ZA; Dang, MC; Del Fabbro, EG; Sima, AP, 2021) |
| " This case report illustrates the potential for cannabidiol to interact with stable medication regimens." | 1.56 | Clinically Significant Drug-Drug Interaction Between Methadone and Cannabidiol. ( Bruera, E; Madden, K; Tanco, K, 2020) |
| " Information on demographics, dosing of methadone, and the use of electrocardiograms (ECGs) was collected." | 1.51 | Attitudes, Beliefs, and Practices of Pediatric Palliative Care Physicians Regarding the Use of Methadone in Children With Advanced Cancer. ( Bruera, E; Liu, D; Madden, K, 2019) |
| "Cancer pain is often not well controlled and there is a need for improved treatment strategies." | 1.48 | Improved Pain Control in Terminally Ill Cancer Patients by Introducing Low-Dose Oral Methadone in Addition to Ongoing Opioid Treatment. ( Fürst, P; Klepstad, P; Lundström, S; Runesdotter, S; Strang, P, 2018) |
| "Methadone is an attractive medication for treating children with advanced cancer with pain as it is the only long-acting opioid available as a liquid." | 1.48 | Methadone as the Initial Long-Acting Opioid in Children with Advanced Cancer. ( Bruera, E; Dibaj, S; Liu, D; Madden, K; Mills, S; Williams, JL, 2018) |
| "Methadone can cause a prolonged QTc interval that can lead to ventricular arrhythmias." | 1.46 | The frequency of QTc prolongation among pediatric and young adult patients receiving methadone for cancer pain. ( Bruera, E; Liu, D; Madden, K; Park, M, 2017) |
| "Compared with nociceptive pain, neuropathic pain is a challenging diagnosis to make and successfully treat in children with cancer." | 1.46 | Very-Low-Dose Methadone To Treat Refractory Neuropathic Pain in Children with Cancer. ( Bruera, E; Madden, K, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 23 (41.07) | 24.3611 |
| 2020's | 33 (58.93) | 2.80 |
| Authors | Studies |
|---|---|
| Irwin, MN | 1 |
| Ellingrod, VL | 1 |
| Smith, MA | 1 |
| Takemura, M | 1 |
| Niki, K | 1 |
| Okamoto, Y | 1 |
| Matsuda, Y | 3 |
| Omae, T | 1 |
| Takagi, T | 1 |
| Ueda, M | 1 |
| Treillet, E | 1 |
| Giet, O | 1 |
| Picard, S | 1 |
| Laurent, S | 1 |
| Seresse, L | 1 |
| Merlin, JS | 1 |
| Khodyakov, D | 2 |
| Arnold, R | 2 |
| Bulls, HW | 1 |
| Dao, E | 2 |
| Kapo, J | 2 |
| King, C | 1 |
| Meier, D | 2 |
| Paice, J | 2 |
| Ritchie, C | 2 |
| Liebschutz, JM | 1 |
| Ozberk, D | 1 |
| Haywood, A | 1 |
| Sutherland, HG | 1 |
| Yu, C | 1 |
| Albury, CL | 1 |
| Zunk, M | 1 |
| George, R | 1 |
| Good, P | 1 |
| Griffiths, LR | 1 |
| Hardy, J | 1 |
| Haupt, LM | 1 |
| Mercadante, S | 4 |
| Adile, C | 1 |
| Ferrera, P | 1 |
| Pallotti, MC | 1 |
| Ricci, M | 1 |
| Bonanno, G | 1 |
| Casuccio, A | 1 |
| Fitzgerald Jones, K | 1 |
| Bulls, H | 1 |
| Liebschutz, J | 1 |
| Merlin, J | 1 |
| Ding, H | 2 |
| Song, Y | 2 |
| Xin, W | 2 |
| Sun, J | 2 |
| Zhong, L | 2 |
| Zhou, Q | 2 |
| He, C | 2 |
| Gong, L | 2 |
| Fang, L | 2 |
| Michael, N | 2 |
| Sulistio, M | 2 |
| Wojnar, R | 2 |
| Gorelik, A | 1 |
| Dräger, DL | 1 |
| Fürst, P | 3 |
| Lundström, S | 3 |
| Klepstad, P | 2 |
| Strang, P | 3 |
| Edmonds, KP | 1 |
| Saunders, IM | 1 |
| Willeford, A | 1 |
| Ajayi, TA | 1 |
| Atayee, RS | 1 |
| von der Brelie, C | 1 |
| Schatlo, B | 1 |
| Bettag, C | 1 |
| Rohde, V | 1 |
| Rosenberg, LB | 1 |
| Heung, Y | 1 |
| Reddy, A | 1 |
| Tan, C | 1 |
| Wong, JF | 1 |
| Yee, CM | 1 |
| Hum, A | 1 |
| Madden, K | 7 |
| Tanco, K | 1 |
| Bruera, E | 9 |
| Kreutzwiser, D | 1 |
| Tawfic, QA | 1 |
| Hanna, V | 1 |
| Senderovich, H | 1 |
| Key, S | 1 |
| Kwok, J | 1 |
| Al-Rubaie, Z | 1 |
| Hall, EA | 2 |
| Sauer, HE | 1 |
| Habashy, C | 2 |
| Anghelescu, DL | 2 |
| Curry, ZA | 1 |
| Dang, MC | 1 |
| Sima, AP | 1 |
| Abdullaziz, S | 1 |
| Del Fabbro, EG | 1 |
| Butler, SH | 1 |
| Mammana, G | 1 |
| Bertolino, M | 1 |
| Orellana, F | 1 |
| Vega, F | 1 |
| Peirano, G | 1 |
| Bunge, S | 1 |
| Armesto, A | 2 |
| Dran, G | 2 |
| Ferreira, LA | 1 |
| Aoki, CT | 1 |
| Santos, DC | 1 |
| Rezende, MJ | 1 |
| Mendes, MP | 1 |
| Moura, RA | 1 |
| Delgado, MA | 1 |
| Ferreira, J | 1 |
| Gomez, MV | 1 |
| Castro Junior, CJ | 1 |
| Duarte, FCN | 1 |
| Ferraro, LHDC | 1 |
| Ferreira, A | 1 |
| Sakata, RK | 1 |
| Okayama, S | 2 |
| Park, M | 2 |
| Liu, D | 5 |
| Hawley, P | 1 |
| Chow, L | 1 |
| Fyles, G | 1 |
| Shokoohi, A | 1 |
| O'Leary, MJ | 1 |
| Mittelstadt, M | 1 |
| Wiffen, PJ | 1 |
| Wee, B | 1 |
| Derry, S | 1 |
| Bell, RF | 1 |
| Moore, RA | 1 |
| Runesdotter, S | 1 |
| Fredheim, OMS | 1 |
| Mills, S | 1 |
| Dibaj, S | 1 |
| Williams, JL | 2 |
| Springer, E | 1 |
| Michenot, N | 1 |
| Rostaing, S | 1 |
| Baron, L | 1 |
| Faure, S | 1 |
| Jovenin, N | 1 |
| Hubault, P | 1 |
| Delorme, T | 1 |
| Collin, E | 1 |
| Filbet, M | 2 |
| Chvetzoff, G | 2 |
| Delorme, C | 1 |
| Minello, C | 1 |
| Magnet, M | 1 |
| Ammar, D | 1 |
| Krakowski, I | 1 |
| Poulain, P | 2 |
| Picco Brunetto, AG | 1 |
| Lovell, AG | 1 |
| Protus, BM | 1 |
| Saphire, ML | 1 |
| Kale, SS | 1 |
| Lehman, A | 1 |
| Hartman, A | 1 |
| Yoshikawa, Y | 1 |
| Piccininni, JA | 1 |
| Killinger, JS | 1 |
| Hammad, HT | 1 |
| Gerber, LM | 1 |
| Dayton, JD | 1 |
| Santos Suárez, J | 1 |
| Del Valle Arnáez, G | 1 |
| Jo, E | 1 |
| Flory, JH | 1 |
| Wiesenthal, AC | 1 |
| Thaler, HT | 1 |
| Koranteng, L | 1 |
| Moryl, N | 1 |
| Peirano, GP | 1 |
| Mammana, GP | 1 |
| Bertolino, MS | 1 |
| Pastrana, T | 1 |
| Vega, GF | 1 |
| Russo, J | 1 |
| Varela, G | 1 |
| Vignaroli, E | 1 |
| Ruggiero, R | 1 |
| Camerano, G | 1 |
| Porta-Sales, J | 1 |
| Garzón-Rodríguez, C | 1 |
| Villavicencio-Chávez, C | 1 |
| Llorens-Torromé, S | 1 |
| González-Barboteo, J | 1 |
| Haumann, J | 1 |
| Geurts, JW | 1 |
| van Kuijk, SM | 1 |
| Kremer, B | 1 |
| Joosten, EA | 1 |
| van den Beuken-van Everdingen, MH | 1 |
| Berleur, MP | 1 |
| Lefki, S | 1 |
| Lefebvre, D | 1 |
| Serra, E | 1 |
| Tremellat, F | 1 |
| Derniaux, A | 1 |
| Hofbauer, H | 1 |
| Schenk, M | 1 |
| Kieselbach, K | 1 |
| Wirz, S | 1 |
| Juba, KM | 1 |
| Khadem, TM | 1 |
| Hutchinson, DJ | 1 |
| Brown, JE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Analgesic Effect Evaluation of Methadone Associated With Morphine for Cancer Pain: Prospective Randomized Study[NCT03324815] | 40 participants (Anticipated) | Interventional | 2017-03-02 | Recruiting | |||
| Methadone for 'Adenocarcinopathic' Pain Treatment: Methadone vs. Morphine Vanguard RCT[NCT05325164] | Phase 3 | 0 participants (Actual) | Interventional | 2022-09-30 | Withdrawn (stopped due to Trial not started; change in Sponsor and Principal Investigator, trial to be registered again by new Sponsor/Investigator if it is started.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for methadone and Cancer-Associated Pain
| Article | Year |
|---|---|
Methadone Switching for Cancer Pain: A New Classification of Initiation Protocols, Based on a Critical Literature Review.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Morphine; Neoplasms; Pain; Randomized Controlled | 2021 |
Intravenous Methadone for Perioperative and Chronic Cancer Pain: A Review of the Literature.
Topics: Analgesics; Analgesics, Opioid; Cancer Pain; Chronic Pain; Humans; Methadone; Neoplasms; Pain, Posto | 2023 |
Opioid-induced Neurotoxicity in Patients with Cancer Pain.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Neoplasms; Pain; Palliative Care | 2023 |
Emerging Challenges to the Safe and Effective Use of Methadone for Cancer-Related Pain in Paediatric and Adult Patient Populations.
Topics: Adult; Analgesics, Opioid; Cancer Pain; Child; Humans; Methadone; Pain Management | 2020 |
How to Use Methadone in an Era of an Opioid Epidemic.
Topics: Analgesics, Opioid; Cancer Pain; Clinical Decision-Making; Disease Management; Humans; Methadone; Op | 2020 |
Methadone for Pain Management: A Pharmacotherapeutic Review.
Topics: Analgesics, Opioid; Cancer Pain; Chronic Pain; Humans; Methadone; Pain Management; Prospective Studi | 2020 |
Methadone in Pain Management: A Systematic Review.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Neuralgia; Nociceptive Pain; Outcome Assessment, | 2021 |
Opioids for cancer pain - an overview of Cochrane reviews.
Topics: Acetaminophen; Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Buprenorphine; C | 2017 |
Methadone as a First-Line Opioid in Cancer Pain Management: A Systematic Review.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Pain Management | 2018 |
[Pain management for cancer patients in drug-assisted rehabilitation].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2018 |
Methadone for Pain Management in Children with Cancer.
Topics: Analgesics, Opioid; Cancer Pain; Child; Humans; Methadone; Neoplasms; Pain Management; Pain Measurem | 2018 |
[Opioid switch and change of route of administration in cancer patients treated by morphine].
Topics: Administration, Oral; Analgesics, Opioid; Breakthrough Pain; Cancer Pain; Drug Substitution; Fentany | 2018 |
5 trials available for methadone and Cancer-Associated Pain
| Article | Year |
|---|---|
Methadone rotation versus other opioid rotation for refractory cancer induced bone pain: protocol of an exploratory randomised controlled open-label study.
Topics: Adolescent; Analgesics, Opioid; Australia; Bone Neoplasms; Breakthrough Pain; Cancer Pain; Humans; M | 2023 |
A Randomized Controlled Trial Evaluating the Analgesic Effect of the Combination of Methadone With Morphine for Cancer Related Pain.
Topics: Analgesics; Analgesics, Opioid; Cancer Pain; Humans; Methadone; Morphine; Neoplasms | 2021 |
Efficacy and Safety of Methadone as a Second-Line Opioid for Cancer Pain in an Outpatient Clinic: A Prospective Open-Label Study.
Topics: Aged; Ambulatory Care Facilities; Cancer Pain; Dose-Response Relationship, Drug; Female; Humans; Mal | 2016 |
Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
Topics: Adult; Aged; Analgesics, Opioid; Cancer Pain; Female; Fentanyl; Head and Neck Neoplasms; Humans; Mal | 2016 |
Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer-Related Pain: The EQUIMETH2 Trial (Methadone for Cancer-Related Pain).
Topics: Analgesics, Opioid; Breakthrough Pain; Cancer Pain; Drug Overdose; Female; Follow-Up Studies; Humans | 2016 |
39 other studies available for methadone and Cancer-Associated Pain
| Article | Year |
|---|---|
Pharmacogenetics of Methadone for Pain Management in Palliative Care.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Neoplasms; Pain Management; Palliative Care; Pha | 2022 |
Tapentadol in Cancer Patients with Neuropathic Pain: A Comparison of Methadone, Oxycodone, Fentanyl, and Hydromorphone.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, Drug; F | 2021 |
Expert Panel Consensus on Management of Advanced Cancer-Related Pain in Individuals With Opioid Use Disorder.
Topics: Adult; Buprenorphine, Naloxone Drug Combination; Cancer Pain; Delphi Technique; Female; Humans; Male | 2021 |
Association of polymorphisms in
Topics: Analgesics, Opioid; beta-Arrestin 2; Cancer Pain; Humans; Methadone; Neoplasms; Pain; Polymorphism, | 2022 |
Methadone as First-line Opioid for the Management of Cancer Pain.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Neoplasms; Pain; Prospective Studies | 2022 |
Consensus-Based Guidance on Opioid Management in Individuals With Advanced Cancer-Related Pain and Opioid Misuse or Use Disorder.
Topics: Analgesics, Opioid; Benzodiazepines; Buprenorphine; Cancer Pain; Consensus; Female; Humans; Male; Me | 2022 |
Methadone switching for refractory cancer pain.
Topics: Analgesics, Opioid; Breakthrough Pain; Cancer Pain; Humans; Methadone; Neoplasms; Retrospective Stud | 2022 |
[Drug therapy for cancer-related pain-evidence regarding hydromorphone, oxycodone, and methadone : Presentation and summary of three Cochrane reviews].
Topics: Analgesics, Opioid; Cancer Pain; Humans; Hydromorphone; Methadone; Neoplasms; Oxycodone | 2023 |
Reply to "A better interpretation of data regarding the opioid switching to methadone".
Topics: Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, Drug; Humans; Methadone; Neoplasms; Pai | 2023 |
The Use of Low-Dose Methadone as Add-On to Regular Opioid Therapy in Cancer-Related Pain at End of Life: A National Swedish Survey in Specialized Palliative Care.
Topics: Analgesics, Opioid; Cancer Pain; Death; Humans; Methadone; Neoplasms; Palliative Care; Sweden | 2020 |
Safety aspects of opioid-naïve patients with high-grade glioma treated with D,L-Methadone: an observational case series.
Topics: Adult; Analgesics, Opioid; Brain Neoplasms; Cancer Pain; Female; Glioma; Humans; Male; Methadone; Mi | 2021 |
What Are Two Days Worth? Facing Dilemmas Together at the End of Life.
Topics: Adult; Analgesics, Opioid; Cancer Pain; Humans; Hypnotics and Sedatives; Informed Consent; Male; Met | 2020 |
Methadone in Swedish specialized palliative care-Is it the magic bullet in complex cancer-related pain?
Topics: Adult; Aged; Cancer Pain; Drug Prescriptions; Female; Health Knowledge, Attitudes, Practice; Humans; | 2020 |
Methadone rotation for cancer pain: an observational study.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Morphine; Neoplasms; Neuralgia | 2022 |
Clinically Significant Drug-Drug Interaction Between Methadone and Cannabidiol.
Topics: Adolescent; Analgesics, Opioid; Cancer Pain; Cannabidiol; Drug Interactions; Drug Therapy, Combinati | 2020 |
The role of methadone in cancer-induced bone pain: a retrospective cohort study.
Topics: Aged; Analgesics, Opioid; Bone and Bones; Cancer Pain; Female; Humans; Male; Methadone; Neoplasms; P | 2021 |
Methadone for Cancer Pain in Pediatric End-of-Life Care.
Topics: Analgesics, Opioid; Cancer Pain; Child; Drug Tolerance; Humans; Methadone; Neoplasms; Retrospective | 2021 |
Combination therapy with methadone and duloxetine for cancer-related pain: a retrospective study.
Topics: Cancer Pain; Duloxetine Hydrochloride; Humans; Methadone; Neoplasms; Retrospective Studies; Treatmen | 2021 |
Some controversies related to questionable clinical uses of methadone for chronic non-cancer pain and in palliative care.
Topics: Analgesics, Opioid; Cancer Pain; Chronic Pain; Humans; Methadone; Palliative Care | 2021 |
First-line methadone for cancer pain: titration time analysis.
Topics: Analgesics, Opioid; Breakthrough Pain; Cancer Pain; Dose-Response Relationship, Drug; Humans; Methad | 2021 |
Antinociceptive synergism upon the joint use of methadone and Phα1β in a model of cancer-related pain in C57BL/6J mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Cancer Pain; Dr | 2021 |
Assistance of a Palliative Care Certified Nurse in the Alleviation of Refractory Cancer Pain by Switching Opioids to Oral Methadone in a Japanese Outpatient Setting.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Japan; Methadone; Neoplasms; Outpatients; Pain, Intractable | 2021 |
The frequency of QTc prolongation among pediatric and young adult patients receiving methadone for cancer pain.
Topics: Adolescent; Adult; Analgesics, Opioid; Cancer Pain; Child; Child, Preschool; Dose-Response Relations | 2017 |
Clinical Outcomes of Start-Low, Go-Slow Methadone Initiation for Cancer-Related Pain: What's the Hurry?
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, Drug; F | 2017 |
Very-Low-Dose Methadone To Treat Refractory Neuropathic Pain in Children with Cancer.
Topics: Amines; Analgesics; Analgesics, Opioid; Cancer Pain; Child; Child, Preschool; Chronic Pain; Cyclohex | 2017 |
Improved Pain Control in Terminally Ill Cancer Patients by Introducing Low-Dose Oral Methadone in Addition to Ongoing Opioid Treatment.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cancer Pain; Dose-Response | 2018 |
Methadone as the Initial Long-Acting Opioid in Children with Advanced Cancer.
Topics: Adolescent; Analgesics, Opioid; Cancer Pain; Child; Female; Humans; Male; Methadone; Pain Management | 2018 |
Practices, Attitudes, and Beliefs of Palliative Care Physicians Regarding the Use of Methadone and Other Long-Acting Opioids in Children with Advanced Cancer.
Topics: Adult; Analgesics, Opioid; Cancer Pain; Child; Female; Health Knowledge, Attitudes, Practice; Humans | 2018 |
Intravenous methadone in a patient with advanced cancer.
Topics: Administration, Intravenous; Analgesics, Opioid; Cancer Pain; Humans; Male; Methadone; Middle Aged; | 2019 |
Evaluation of QTc Interval Prolongation Among Patients With Cancer Using Enteral Methadone.
Topics: Adult; Aged; Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, Drug; Female; Humans; Long | 2019 |
Attitudes, Beliefs, and Practices of Pediatric Palliative Care Physicians Regarding the Use of Methadone in Children With Advanced Cancer.
Topics: Administration, Intravenous; Administration, Oral; Adult; Aged; Analgesics, Opioid; Cancer Pain; Chi | 2019 |
A Comparative Study of Opioid Switching to Methadone for Cancer Pain Control in Successful and Unsuccessful Cases.
Topics: Aged; Analgesics, Opioid; Cancer Pain; Drug Substitution; Female; Humans; Japan; Male; Methadone; Mi | 2019 |
QT Interval Prolongation in the Pediatric Oncologic Population on Methadone.
Topics: Adolescent; Adult; Analgesics, Opioid; Cancer Pain; Child; Child, Preschool; Female; Follow-Up Studi | 2020 |
Morphine infusor pump switch to oral methadone.
Topics: Administration, Oral; Aged; Analgesics, Opioid; Cancer Pain; Dose-Response Relationship, Drug; Drug | 2020 |
Corrected QT Interval Prolongation in Pediatric and Young Adult Patients on Methadone for Cancer-Related Pain.
Topics: Adolescent; Adult; Age Factors; Analgesics, Opioid; Cancer Pain; Child; Child, Preschool; Electrocar | 2019 |
Methadone Use and the Risk of Hypoglycemia for Inpatients With Cancer Pain.
Topics: Adult; Aged; Analgesics, Opioid; Blood Glucose; Cancer Pain; Dose-Response Relationship, Drug; Femal | 2016 |
Methadone as first-line opioid treatment for cancer pain in a developing country palliative care unit.
Topics: Analgesics, Opioid; Cancer Pain; Developing Countries; Female; Humans; Male; Methadone; Middle Aged; | 2016 |
[Use of methadone for support of oncological treatment? : Statement of the working group on tumor pain of the German Pain Society].
Topics: Analgesics, Opioid; Antineoplastic Agents; Brain Neoplasms; Cancer Pain; Drug Approval; Drug Resista | 2017 |
Methadone and Corrected QT Prolongation in Pain and Palliative Care Patients: A Case-Control Study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cancer Pain; Case-Control Studies; Dose-Response | 2017 |