methadone has been researched along with Burns in 14 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the past 2 years, oral methadone has been used extensively in our institution for treating children with persistent pain from cancer, burns, or trauma who were capable of oral intake and whose pain was not relieved by nonopioid medications." | 7.70 | Oral methadone for the treatment of severe pain in hospitalized children: a report of five cases. ( Davidson, EM; Rosen, G; Shavelson, V; Shenkman, Z; Shir, Y, 1998) |
| "Serotonin syndrome is a syndrome identified by a triad of altered mental status, neuromuscular overactivity, and autonomic instability caused by the overstimulation of serotonin in the central nervous system and periphery." | 5.42 | Serotonin syndrome caused by fentanyl and methadone in a burn injury. ( Gala, G; Hillman, AD; Sultan, SM; Witenko, CJ, 2015) |
| " In the past 2 years, oral methadone has been used extensively in our institution for treating children with persistent pain from cancer, burns, or trauma who were capable of oral intake and whose pain was not relieved by nonopioid medications." | 3.70 | Oral methadone for the treatment of severe pain in hospitalized children: a report of five cases. ( Davidson, EM; Rosen, G; Shavelson, V; Shenkman, Z; Shir, Y, 1998) |
| "The pharmacokinetics of methadone were studied in 14 patients with acute, severe burns and receiving an intravenous infusion of methadone to control their pain." | 3.68 | Pharmacokinetics of continuous intravenous infusion of methadone in the early post-burn period. ( Concilus, RR; Denson, DD; Raj, PP; Warden, G, 1990) |
| "Methadone is a long-acting analgesic that targets the N-methyl-D-aspartate (NMDA) receptor in addition to the mu opioid receptor and has benefit in adult burn patients." | 1.72 | Intraoperative Methadone Use in Pediatric Burn Patients. ( Ambardekar, A; Carlson, A; Iskander, I; Pham, D; Price, C; Reisch, J, 2022) |
| "Methadone is an opioid commonly used for acute pain management in burn patients." | 1.56 | Risk Factors and Prevalence of QTc Prolongation in Adult Burn Patients Receiving Methadone. ( Boyd, AN; Hartman, BC; Hester, AM; Schoenle, MK; Sood, R; Walroth, TA, 2020) |
| "Serotonin syndrome is a syndrome identified by a triad of altered mental status, neuromuscular overactivity, and autonomic instability caused by the overstimulation of serotonin in the central nervous system and periphery." | 1.42 | Serotonin syndrome caused by fentanyl and methadone in a burn injury. ( Gala, G; Hillman, AD; Sultan, SM; Witenko, CJ, 2015) |
| "Conventional pharmacotherapies against neuropathic pain were attempted to control pain for over 5 years." | 1.31 | Successful use of methadone in the treatment of chronic neuropathic pain arising from burn injuries: a case-study. ( Altier, N; Boulanger, A; Choinière, M; Dion, D, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Carlson, A | 1 |
| Pham, D | 1 |
| Price, C | 1 |
| Reisch, J | 1 |
| Iskander, I | 1 |
| Ambardekar, A | 1 |
| Walroth, TA | 1 |
| Boyd, AN | 1 |
| Hester, AM | 1 |
| Schoenle, MK | 1 |
| Hartman, BC | 1 |
| Sood, R | 1 |
| Hillman, AD | 1 |
| Witenko, CJ | 1 |
| Sultan, SM | 1 |
| Gala, G | 2 |
| Saxon, AJ | 1 |
| Atkinson, TJ | 1 |
| Fudin, J | 1 |
| Pham, TC | 1 |
| Hillman, A | 1 |
| Witenko, C | 1 |
| Sultan, S | 1 |
| Romich, TJ | 1 |
| Horan, PM | 1 |
| Catanese, CA | 1 |
| Sullivan, SR | 1 |
| Friedrich, JB | 1 |
| Engrav, LH | 1 |
| Round, KA | 1 |
| Heimbach, DM | 1 |
| Heckbert, SR | 1 |
| Carrougher, GJ | 1 |
| Lezotte, DC | 1 |
| Wiechman, SA | 1 |
| Honari, S | 1 |
| Klein, MB | 1 |
| Gibran, NS | 1 |
| Kehlet, H | 1 |
| Williams, PI | 1 |
| Sarginson, RE | 1 |
| Ratcliffe, JM | 1 |
| Shir, Y | 2 |
| Shenkman, Z | 1 |
| Shavelson, V | 1 |
| Davidson, EM | 1 |
| Rosen, G | 2 |
| Shvelzon, V | 1 |
| Altier, N | 1 |
| Dion, D | 1 |
| Boulanger, A | 1 |
| Choinière, M | 1 |
| Denson, DD | 1 |
| Concilus, RR | 1 |
| Warden, G | 1 |
| Raj, PP | 1 |
| Wood, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| IRB-HSR# 14145 R,S Methadone: Analgesia and Pharmacokinetics in Adolescents Undergoing Scoliosis Correction[NCT01205256] | Phase 3 | 11 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for methadone and Burns
| Article | Year |
|---|---|
Plasma drug binding: implications for anesthesiologists.
Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Ca | 1986 |
13 other studies available for methadone and Burns
| Article | Year |
|---|---|
Intraoperative Methadone Use in Pediatric Burn Patients.
Topics: Adult; Analgesics, Opioid; Burns; Child; Humans; Methadone; Morphine; Pain; Retrospective Studies | 2022 |
Risk Factors and Prevalence of QTc Prolongation in Adult Burn Patients Receiving Methadone.
Topics: Adult; Burns; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Indiana; Long Q | 2020 |
Serotonin syndrome caused by fentanyl and methadone in a burn injury.
Topics: Adult; Analgesics, Opioid; Burns; Drug Interactions; Drug Therapy, Combination; Fentanyl; Humans; Ma | 2015 |
Commentary on Burns et al. (2015): retention in buprenorphine treatment.
Topics: Buprenorphine; Burns; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders | 2015 |
Combined fentanyl and methadone induced serotonin syndrome is called into question.
Topics: Analgesics, Opioid; Burns; Fentanyl; Humans; Male; Methadone; Serotonin Syndrome | 2015 |
Accidental fire fatality with sustained combustion.
Topics: Accidents; Automobiles; Burns; Carbon Monoxide; Cocaine; Fires; Forensic Pathology; Humans; Male; Me | 2010 |
"Opioid creep" is real and may be the cause of "fluid creep".
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Body Surface Area; Burns; Female; Fentanyl; Fluid Thera | 2004 |
Should regional anesthesia and pharmacological agents such as beta blockers and opiates be utilized in modulating pain response?
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alfentanil; Analgesia; Analgesics; Anesth | 1984 |
Use of methadone in the morphine-tolerant burned paediatric patient.
Topics: Analgesics, Opioid; Burns; Child; Conscious Sedation; Critical Care; Drug Tolerance; Female; Humans; | 1998 |
Oral methadone for the treatment of severe pain in hospitalized children: a report of five cases.
Topics: Administration, Oral; Analgesia, Patient-Controlled; Analgesics, Opioid; Burns; Child; Child, Presch | 1998 |
[Treating hospitalized children in severe pain with oral methadone].
Topics: Administration, Oral; Analgesics, Opioid; Burns; Child; Child, Hospitalized; Child, Preschool; Femal | 1998 |
Successful use of methadone in the treatment of chronic neuropathic pain arising from burn injuries: a case-study.
Topics: Analgesics, Opioid; Burns; Chronic Disease; Humans; Leg Injuries; Male; Methadone; Middle Aged; Neur | 2001 |
Pharmacokinetics of continuous intravenous infusion of methadone in the early post-burn period.
Topics: Adult; Aged; Burns; Humans; Infusions, Intravenous; Methadone; Middle Aged; Regression Analysis; Ser | 1990 |