methadone has been researched along with Breakthrough Pain in 6 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Breakthrough Pain: Acute pain that comes on rapidly despite the use of pain medication.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methadone is commonly considered an alternative opioid treatment for refractory cancer pain." | 8.12 | Methadone switching for refractory cancer pain. ( Ding, H; Fang, L; Gong, L; He, C; Song, Y; Sun, J; Xin, W; Zhong, L; Zhou, Q, 2022) |
| "To describe the titration phase of the treatment with low-dose first-line methadone and the use of methadone for breakthrough pain." | 8.02 | First-line methadone for cancer pain: titration time analysis. ( Armesto, A; Bertolino, M; Bruera, E; Bunge, S; Dran, G; Mammana, G; Orellana, F; Peirano, G; Vega, F, 2021) |
| "In the European Association for Palliative Care recommendations for cancer pain management, there was no consensus regarding the indications, titration, or monitoring of methadone." | 5.22 | Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer-Related Pain: The EQUIMETH2 Trial (Methadone for Cancer-Related Pain). ( Berleur, MP; Chvetzoff, G; Derniaux, A; Filbet, M; Lefebvre, D; Lefki, S; Poulain, P; Serra, E; Tremellat, F, 2016) |
| " A group of experts nominated by the 3 French Societies involved in the treatment of cancer pain (AFSOS, SFAP, SFETD), established new guidelines ratios for morphine switching and/or changing of route of administration, in patients for whom either pain was not adequatly managed or adverse effects were unbearable." | 4.98 | [Opioid switch and change of route of administration in cancer patients treated by morphine]. ( Ammar, D; Baron, L; Chvetzoff, G; Collin, E; Delorme, C; Delorme, T; Faure, S; Filbet, M; Hubault, P; Jovenin, N; Krakowski, I; Magnet, M; Michenot, N; Minello, C; Poulain, P; Rostaing, S, 2018) |
| "Methadone is commonly considered an alternative opioid treatment for refractory cancer pain." | 4.12 | Methadone switching for refractory cancer pain. ( Ding, H; Fang, L; Gong, L; He, C; Song, Y; Sun, J; Xin, W; Zhong, L; Zhou, Q, 2022) |
| "To describe the titration phase of the treatment with low-dose first-line methadone and the use of methadone for breakthrough pain." | 4.02 | First-line methadone for cancer pain: titration time analysis. ( Armesto, A; Bertolino, M; Bruera, E; Bunge, S; Dran, G; Mammana, G; Orellana, F; Peirano, G; Vega, F, 2021) |
| "IV-PCA provided timely, safe and useful analgesia for patients with severe breakthrough pain and may be useful to help titration of opioids, weaning to oral analgesia and to decide for interventional procedures." | 1.40 | Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study. ( Ashmawi, HA; Cascudo, GM; de Santana Neto, J; Guimaraes, GM; Neto, JO; Sousa, AM, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ding, H | 1 |
| Song, Y | 1 |
| Xin, W | 1 |
| Sun, J | 1 |
| Zhong, L | 1 |
| Zhou, Q | 1 |
| He, C | 1 |
| Gong, L | 1 |
| Fang, L | 1 |
| Michael, N | 1 |
| Sulistio, M | 1 |
| Wojnar, R | 1 |
| Gorelik, A | 1 |
| Mammana, G | 1 |
| Bertolino, M | 1 |
| Bruera, E | 1 |
| Orellana, F | 1 |
| Vega, F | 1 |
| Peirano, G | 1 |
| Bunge, S | 1 |
| Armesto, A | 1 |
| Dran, G | 1 |
| Michenot, N | 1 |
| Rostaing, S | 1 |
| Baron, L | 1 |
| Faure, S | 1 |
| Jovenin, N | 1 |
| Hubault, P | 1 |
| Delorme, T | 1 |
| Collin, E | 1 |
| Filbet, M | 2 |
| Chvetzoff, G | 2 |
| Delorme, C | 1 |
| Minello, C | 1 |
| Magnet, M | 1 |
| Ammar, D | 1 |
| Krakowski, I | 1 |
| Poulain, P | 2 |
| Sousa, AM | 1 |
| de Santana Neto, J | 1 |
| Guimaraes, GM | 1 |
| Cascudo, GM | 1 |
| Neto, JO | 1 |
| Ashmawi, HA | 1 |
| Berleur, MP | 1 |
| Lefki, S | 1 |
| Lefebvre, D | 1 |
| Serra, E | 1 |
| Tremellat, F | 1 |
| Derniaux, A | 1 |
1 review available for methadone and Breakthrough Pain
| Article | Year |
|---|---|
[Opioid switch and change of route of administration in cancer patients treated by morphine].
Topics: Administration, Oral; Analgesics, Opioid; Breakthrough Pain; Cancer Pain; Drug Substitution; Fentany | 2018 |
2 trials available for methadone and Breakthrough Pain
| Article | Year |
|---|---|
Methadone rotation versus other opioid rotation for refractory cancer induced bone pain: protocol of an exploratory randomised controlled open-label study.
Topics: Adolescent; Analgesics, Opioid; Australia; Bone Neoplasms; Breakthrough Pain; Cancer Pain; Humans; M | 2023 |
Efficacy and Safety of Two Methadone Titration Methods for the Treatment of Cancer-Related Pain: The EQUIMETH2 Trial (Methadone for Cancer-Related Pain).
Topics: Analgesics, Opioid; Breakthrough Pain; Cancer Pain; Drug Overdose; Female; Follow-Up Studies; Humans | 2016 |
3 other studies available for methadone and Breakthrough Pain
| Article | Year |
|---|---|
Methadone switching for refractory cancer pain.
Topics: Analgesics, Opioid; Breakthrough Pain; Cancer Pain; Humans; Methadone; Neoplasms; Retrospective Stud | 2022 |
First-line methadone for cancer pain: titration time analysis.
Topics: Analgesics, Opioid; Breakthrough Pain; Cancer Pain; Dose-Response Relationship, Drug; Humans; Methad | 2021 |
Safety profile of intravenous patient-controlled analgesia for breakthrough pain in cancer patients: a case series study.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Breakthrough Pain; Constipation; Female; Fentanyl; | 2014 |