methadone has been researched along with Brain Neoplasms in 10 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methadone, which is used as maintenance medication for outpatient treatment of opioid dependence or as an analgesic drug, has been suggested by preclinical in vitro and mouse studies to induce cell death and sensitivity to chemo- or radiotherapy in leukemia, glioblastoma, and carcinoma cells." | 9.05 | Against Repurposing Methadone for Glioblastoma Therapy. ( Eckert, F; Ganser, K; Huber, SM; Klumpp, L; Stransky, N; Vatter, T; Zips, D, 2020) |
| "It was suggested that D, L-Methadone might improve the clinical course of glioma patients." | 8.02 | Safety aspects of opioid-naïve patients with high-grade glioma treated with D,L-Methadone: an observational case series. ( Bettag, C; Rohde, V; Schatlo, B; von der Brelie, C, 2021) |
| "D,L-methadone (MET), an analgesic drug used for pain treatment and opiate addiction, has achieved attention from oncologists and social media as possible chemoensitizing agent in cancer therapy, notably brain cancer (glioblastoma multiforme, GBM)." | 8.02 | Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent. ( Ciftcioglu, J; Eckstein, N; Haas, B; Jermar, S; Kaina, B; Weickhardt, S, 2021) |
| "When only treated with D,L-methadone, 1 µM of the opioid was sufficient to reduce viability of fibroblasts, whereas 10 µM was needed to significantly reduce glioblastoma cell viability." | 7.91 | D,L-Methadone does not improve radio- and chemotherapy in glioblastoma in vitro. ( Baran-Schmidt, R; Dietterle, J; Gaunitz, F; Glasow, A; Matusova, M; Meixensberger, J; Neumann, K; Oppermann, H, 2019) |
| "Recently, D,L-methadone has been put forward as adjuvant treatment in glioblastoma (GBM)." | 7.88 | Efficacy of D,L-methadone in the treatment of glioblastoma in vitro. ( Brawanski, A; Brawanski, K; Brockhoff, G; Freyschlag, C; Hau, P; Lohmeier, A; Proescholdt, MA; Riemenschneider, MJ; Thomé, C; Vollmann-Zwerenz, A, 2018) |
| "D,L-methadone can be safely combined with standard glioma chemotherapy without increasing the risk of toxicity or vegetative symptoms such as tachycardia, sweating and restlessness." | 7.85 | Safety and Tolerance of D,L-Methadone in Combination with Chemotherapy in Patients with Glioma. ( Friesen, C; Misch, M; Onken, J; Vajkoczy, P, 2017) |
| "Methadone, which is used as maintenance medication for outpatient treatment of opioid dependence or as an analgesic drug, has been suggested by preclinical in vitro and mouse studies to induce cell death and sensitivity to chemo- or radiotherapy in leukemia, glioblastoma, and carcinoma cells." | 5.05 | Against Repurposing Methadone for Glioblastoma Therapy. ( Eckert, F; Ganser, K; Huber, SM; Klumpp, L; Stransky, N; Vatter, T; Zips, D, 2020) |
| "It was suggested that D, L-Methadone might improve the clinical course of glioma patients." | 4.02 | Safety aspects of opioid-naïve patients with high-grade glioma treated with D,L-Methadone: an observational case series. ( Bettag, C; Rohde, V; Schatlo, B; von der Brelie, C, 2021) |
| "D,L-methadone (MET), an analgesic drug used for pain treatment and opiate addiction, has achieved attention from oncologists and social media as possible chemoensitizing agent in cancer therapy, notably brain cancer (glioblastoma multiforme, GBM)." | 4.02 | Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent. ( Ciftcioglu, J; Eckstein, N; Haas, B; Jermar, S; Kaina, B; Weickhardt, S, 2021) |
| "When only treated with D,L-methadone, 1 µM of the opioid was sufficient to reduce viability of fibroblasts, whereas 10 µM was needed to significantly reduce glioblastoma cell viability." | 3.91 | D,L-Methadone does not improve radio- and chemotherapy in glioblastoma in vitro. ( Baran-Schmidt, R; Dietterle, J; Gaunitz, F; Glasow, A; Matusova, M; Meixensberger, J; Neumann, K; Oppermann, H, 2019) |
| "Recently, D,L-methadone has been put forward as adjuvant treatment in glioblastoma (GBM)." | 3.88 | Efficacy of D,L-methadone in the treatment of glioblastoma in vitro. ( Brawanski, A; Brawanski, K; Brockhoff, G; Freyschlag, C; Hau, P; Lohmeier, A; Proescholdt, MA; Riemenschneider, MJ; Thomé, C; Vollmann-Zwerenz, A, 2018) |
| "D,L-methadone can be safely combined with standard glioma chemotherapy without increasing the risk of toxicity or vegetative symptoms such as tachycardia, sweating and restlessness." | 3.85 | Safety and Tolerance of D,L-Methadone in Combination with Chemotherapy in Patients with Glioma. ( Friesen, C; Misch, M; Onken, J; Vajkoczy, P, 2017) |
| "Glioblastoma are the most frequent and malignant human brain tumors, having a very poor prognosis." | 1.40 | Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma. ( Alt, A; Debatin, KM; Fichtner, I; Friesen, C; Hilger, R; Hormann, I; Miltner, E; Roscher, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| von der Brelie, C | 1 |
| Schatlo, B | 1 |
| Bettag, C | 1 |
| Rohde, V | 1 |
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
| He, C | 2 |
| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Zhang, X | 6 |
| Xu, N | 1 |
| Wang, R | 1 |
| Liu, S | 1 |
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| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Zhang, C | 3 |
| Chen, L | 2 |
| Yang, X | 1 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
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| Zager, RA | 1 |
| Johnson, ACM | 1 |
| Guillem, A | 1 |
| Keyser, J | 1 |
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| Gentile, GL | 1 |
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| Jones, CR | 1 |
| Bailey, PL | 1 |
| McMahill, PC | 1 |
2 reviews available for methadone and Brain Neoplasms
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Against Repurposing Methadone for Glioblastoma Therapy.
Topics: Antineoplastic Agents; Brain Neoplasms; Drug Repositioning; Glioblastoma; Humans; Methadone; Recepto | 2020 |
1 trial available for methadone and Brain Neoplasms
8 other studies available for methadone and Brain Neoplasms
| Article | Year |
|---|---|
Safety aspects of opioid-naïve patients with high-grade glioma treated with D,L-Methadone: an observational case series.
Topics: Adult; Analgesics, Opioid; Brain Neoplasms; Cancer Pain; Female; Glioma; Humans; Male; Methadone; Mi | 2021 |
Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent.
Topics: Analgesics, Opioid; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumo | 2021 |
Safety and Tolerance of D,L-Methadone in Combination with Chemotherapy in Patients with Glioma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Brain Neoplasms; Clinical Trials as To | 2017 |
Efficacy of D,L-methadone in the treatment of glioblastoma in vitro.
Topics: Adult; Analgesics, Opioid; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, | 2018 |
D,L-Methadone does not improve radio- and chemotherapy in glioblastoma in vitro.
Topics: Adult; Aged; Analgesics, Opioid; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Ce | 2019 |
Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cy | 2014 |
[Use of methadone for support of oncological treatment? : Statement of the working group on tumor pain of the German Pain Society].
Topics: Analgesics, Opioid; Antineoplastic Agents; Brain Neoplasms; Cancer Pain; Drug Approval; Drug Resista | 2017 |
Central neurogenic hyperventilation: pharmacologic intervention with morphine sulfate and correlative analysis of respiratory, sleep, and ocular motor dysfunction.
Topics: Adult; Astrocytoma; Brain Neoplasms; Drug Therapy, Combination; Eye Movements; Female; Humans; Hyper | 1990 |