Page last updated: 2024-10-30

methadone and Brain Edema

methadone has been researched along with Brain Edema in 3 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)

Research Excerpts

ExcerptRelevanceReference
"Here, we report a patient who developed acute bilateral hearing loss, ataxia and paraparesis subsequently to intravenous methadone-abuse."4.02Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments. ( Haessner, S; Johnen, A; Landmeyer, NC; Meyer Zu Hörste, G; Pawlitzki, M; Repple, J; Schulte-Mecklenbeck, A; Wiendl, H, 2021)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Repple, J1
Haessner, S1
Johnen, A1
Landmeyer, NC1
Schulte-Mecklenbeck, A1
Pawlitzki, M1
Wiendl, H1
Meyer Zu Hörste, G1
Winklhofer, S1
Surer, E1
Ampanozi, G1
Ruder, T1
Stolzmann, P1
Elliott, M1
Oestreich, A1
Kraemer, T1
Thali, M1
Alkadhi, H1
Schweitzer, W1
Carson, HJ1
Feickert, BL1

Other Studies

3 other studies available for methadone and Brain Edema

ArticleYear
Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments.
    BMC neurology, 2021, Feb-22, Volume: 21, Issue:1

    Topics: Administration, Intravenous; Analgesics, Opioid; Ataxia; Brain; Brain Diseases; Brain Edema; Cogniti

2021
Post-mortem whole body computed tomography of opioid (heroin and methadone) fatalities: frequent findings and comparison to autopsy.
    European radiology, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Adult; Autopsy; Brain Edema; Cardiomegaly; Cause of Death; Female; Forensic Pathology; H

2014
Identification at autopsy of pulverized pills in lungs of a first-time methadone user.
    Journal of forensic and legal medicine, 2009, Volume: 16, Issue:8

    Topics: Administration, Inhalation; Adult; Brain Edema; Dronabinol; Drug Interactions; Drug Users; Fatal Out

2009