Page last updated: 2024-10-30

methadone and Bradycardia

methadone has been researched along with Bradycardia in 11 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.

Research Excerpts

ExcerptRelevanceReference
"To report the occurrence of bradycardia associated with the use of methadone administered to prevent withdrawal in an infant with physical tolerance following long-term opioid therapy in the pediatric intensive care unit setting."7.73Bradycardia during methadone therapy in an infant. ( Tobias, JD; Wheeler, AD, 2006)
"A 43-year-old man with acute respiratory distress syndrome experienced bradycardia while receiving a continuous infusion of methadone for sedation and mechanical ventilation management."5.31Bradycardia associated with intravenous methadone administered for sedation in a patient with acute respiratory distress syndrome. ( Karir, V, 2002)
"To report the occurrence of bradycardia associated with the use of methadone administered to prevent withdrawal in an infant with physical tolerance following long-term opioid therapy in the pediatric intensive care unit setting."3.73Bradycardia during methadone therapy in an infant. ( Tobias, JD; Wheeler, AD, 2006)
"Where hypotension was present, the method of and response to treatment was recorded."1.36A comparison of anesthetic complications between diabetic and nondiabetic dogs undergoing phacoemulsification cataract surgery: a retrospective study. ( Clark, L; Corletto, F; Gould, DJ; Oliver, JA, 2010)
"A 43-year-old man with acute respiratory distress syndrome experienced bradycardia while receiving a continuous infusion of methadone for sedation and mechanical ventilation management."1.31Bradycardia associated with intravenous methadone administered for sedation in a patient with acute respiratory distress syndrome. ( Karir, V, 2002)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19902 (18.18)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's3 (27.27)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Amon, T1
Kästner, SBR1
Kietzmann, M1
Tünsmeyer, J1
Katz, DF1
Varosy, PD1
Masoudi, FA1
Swenson, O1
Oliver, JA1
Clark, L1
Corletto, F1
Gould, DJ1
Karir, V1
Stoermer, R1
Drewe, J1
Dursteler-Mac Farland, KM1
Hock, C1
Mueller-Spahn, F1
Ladewig, D1
Stohler, R1
Mager, R1
Ashwath, ML1
Ajjan, M1
Culclasure, T1
Wheeler, AD1
Tobias, JD1
Le Page, L1
Lion-Daolio, S1
Guillaumont, MP1
Grignon, P1
Smail, A1
Ducroix, JP1
Eikenburg, DC1
Stickney, JL1
Lipski, J1
Stimmel, B1
Donoso, E1

Trials

1 trial available for methadone and Bradycardia

ArticleYear
Safety of injectable opioid maintenance treatment for heroin dependence.
    Biological psychiatry, 2003, Oct-15, Volume: 54, Issue:8

    Topics: Adult; Bradycardia; Electroencephalography; Female; Heroin Dependence; Humans; Hypoxia; Injections,

2003

Other Studies

10 other studies available for methadone and Bradycardia

ArticleYear
Plasma levels of a methadone constant rate infusion and their corresponding effects on thermal and mechanical nociceptive thresholds in dogs.
    BMC veterinary research, 2021, Jan-18, Volume: 17, Issue:1

    Topics: Administration, Intravenous; Analgesics, Opioid; Animals; Bradycardia; Cross-Over Studies; Dogs; Fem

2021
Syncope: a tale of two triggers.
    JAMA internal medicine, 2013, Sep-09, Volume: 173, Issue:16

    Topics: Bradycardia; Dose-Response Relationship, Drug; Electrocardiography; Humans; Male; Methadone; Middle

2013
Accidental methadone intoxication masquerading as asthma exacerbation with respiratory arrest in a six-year-old boy.
    Delaware medical journal, 2015, Volume: 87, Issue:5

    Topics: Asthma; Bradycardia; Child; Diagnosis, Differential; Drug Overdose; Humans; Male; Methadone; Naloxon

2015
A comparison of anesthetic complications between diabetic and nondiabetic dogs undergoing phacoemulsification cataract surgery: a retrospective study.
    Veterinary ophthalmology, 2010, Volume: 13, Issue:4

    Topics: Acepromazine; Anesthesia, Intravenous; Animals; Bradycardia; Cataract; Diabetes Mellitus; Dog Diseas

2010
Bradycardia associated with intravenous methadone administered for sedation in a patient with acute respiratory distress syndrome.
    Pharmacotherapy, 2002, Volume: 22, Issue:9

    Topics: Adult; Bradycardia; Humans; Infusions, Intravenous; Male; Methadone; Narcotics; Respiration, Artific

2002
Methadone-induced bradycardia.
    The Journal of emergency medicine, 2005, Volume: 29, Issue:1

    Topics: Administration, Oral; Adult; Bradycardia; Diagnosis, Differential; Electrocardiography; Headache; Hu

2005
Bradycardia during methadone therapy in an infant.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2006, Volume: 7, Issue:1

    Topics: Analgesics, Opioid; Anesthetics, Intravenous; Bradycardia; Fentanyl; Humans; Infant; Male; Methadone

2006
[An abnormal electrocardiogram in a drug addict patient].
    La Revue de medecine interne, 2007, Volume: 28, Issue:10

    Topics: Bradycardia; Diagnosis, Differential; Electrocardiography; Humans; Long QT Syndrome; Male; Methadone

2007
Anti-cholinesterase activity of 1-alpha-acetylmethadol: relationship to bradycardia.
    General pharmacology, 1979, Volume: 10, Issue:3

    Topics: Acetylcholinesterase; Animals; Bethanechol Compounds; Bradycardia; Butyrylcholinesterase; Cholineste

1979
The effect of heroin and multiple drug abuse on the electrocardiogram.
    American heart journal, 1973, Volume: 86, Issue:5

    Topics: Adolescent; Adult; Alcoholism; Barbiturates; Bradycardia; Cocaine; Death, Sudden; Electrocardiograph

1973