methadone and Behavior Disorders studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Research Excerpts

Excerpt	Relevance	Reference
" This study investigates HIV, drug use, and mental health stigmas in three dimensions (social, internalized, and professional) around PWH on methadone maintenance treatment (MMT) who have common mental disorders (CMDs) including depression, anxiety, and stress-related disorders in Hanoi, Vietnam."	9.51	Stigma experienced by people living with HIV who are on methadone maintenance treatment and have symptoms of common mental disorders in Hanoi, Vietnam: a qualitative study. ( Chibanda, D; Filipowicz, TR; Gaynes, BN; Go, VF; Ho, HT; Landrum, KR; Le, GM; Nguyen, MX; Nong, HTT; Pence, BW; Tran, HV; Tran, TTT; Verhey, R, 2022)
"Physical activity may improve chronic pain, anxiety, and depression, which are prevalent among patients in methadone maintenance treatment (MMT), but relatively little is known about the physical activity levels or interest in exercise of patients in MMT."	7.83	Physical activity, psychiatric distress, and interest in exercise group participation among individuals seeking methadone maintenance treatment with and without chronic pain. ( Barry, DT; Beitel, M; Cutter, CJ; Eggert, K; Ginn, J; Kerns, RD; Liong, C; Madden, LM; Schottenfeld, RS; Stults-Kolehmainen, M, 2016)
"Differences in psychiatric distress and substance use (licit and illicit) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences."	7.75	Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2009)
" This study investigates HIV, drug use, and mental health stigmas in three dimensions (social, internalized, and professional) around PWH on methadone maintenance treatment (MMT) who have common mental disorders (CMDs) including depression, anxiety, and stress-related disorders in Hanoi, Vietnam."	5.51	Stigma experienced by people living with HIV who are on methadone maintenance treatment and have symptoms of common mental disorders in Hanoi, Vietnam: a qualitative study. ( Chibanda, D; Filipowicz, TR; Gaynes, BN; Go, VF; Ho, HT; Landrum, KR; Le, GM; Nguyen, MX; Nong, HTT; Pence, BW; Tran, HV; Tran, TTT; Verhey, R, 2022)
"Clonidine's actions and efficacy in mental disorders are reviewed and examined."	5.06	Psychiatric indications for clonidine: the neuropharmacologic and clinical basis. ( Bond, WS, 1986)
"Physical activity may improve chronic pain, anxiety, and depression, which are prevalent among patients in methadone maintenance treatment (MMT), but relatively little is known about the physical activity levels or interest in exercise of patients in MMT."	3.83	Physical activity, psychiatric distress, and interest in exercise group participation among individuals seeking methadone maintenance treatment with and without chronic pain. ( Barry, DT; Beitel, M; Cutter, CJ; Eggert, K; Ginn, J; Kerns, RD; Liong, C; Madden, LM; Schottenfeld, RS; Stults-Kolehmainen, M, 2016)
"Methadone is largely used as the primary opioid substitution therapy for the treatment of heroin addiction; the objective of the study was to describe the clinical characteristics of heroin abusers admitted into a methadone maintenance program (MMP) in metropolitan Barcelona."	3.80	[Characteristics of heroin dependent patients admitted to a methadone treatment program]. ( Faure, E; Fuster, D; Muga, R; Muñoz, T; Rivas, I; Rubio, M; Sanvisens, A; Tor, J, 2014)
" Methadone patients will likely experience little harm and a great deal of benefit from treatment with varenicline for smoking cessation."	3.79	Low incidence of adverse events following varenicline initiation among opioid dependent smokers with comorbid psychiatric illness. ( Arnsten, JH; Bernstein, SL; Nahvi, S; Richter, KP; Wu, B, 2013)
" Data on HIV and hepatitis C virus (HCV) infections, methadone dosage, and morphine in the urine were retrieved from patient files on the clinical premises, with permission of the participants."	3.77	Clinical characteristics and risk behavior as a function of HIV status among heroin users enrolled in methadone treatment in northern Taiwan. ( Chou, YC; Chuang, P; Huang, CW; Lee, TS; Liu, YL; Shen, HC; Shih, CY; Wang, BE; Wu, WH; Yen, MY, 2011)
"Comorbid medical illness is common in patients with chronic hepatitis C (HCV) infection and in methadone treatment (MMT) patients, yet little is known about the impact of medical illness on HCV treatment eligibility."	3.76	Hepatitis C treatment eligibility and comorbid medical illness in methadone maintenance (MMT) and non-MMT patients: a case-control study. ( Batki, SL; Canfield, KM; Levine, RA; Ploutz-Snyder, R; Smyth, E, 2010)
"Differences in psychiatric distress and substance use (licit and illicit) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences."	3.75	Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2009)
"Alcohol and cocaine abuse result in unsatisfactory treatment outcomes for heroin and illicit opioid addicts engaged in Methadone Maintenance Treatment Programs (MMTPs)."	3.74	Alcohol and cocaine use and abuse among opioid addicts engaged in a methadone maintenance treatment program. ( Lovrecic, M; Maremmani, I; Marini, G; Mellini, A; Pacini, M; Pani, PP; Perugi, G; Shinderman, M, 2007)
"In 189 opioid-dependent subjects on methadone maintenance treatment in Barcelona (Spain), we assessed the prevalence of co-occurrence substance use and non-substance-use disorders (dual diagnosis) by the Psychiatric Research Interview for Substance and Mental Disorders [PRISM], and the impact on quality of life (HRQoL) by the SF-12 (PCS-12 and MCS-12 scales)."	3.74	Impact of substance dependence and dual diagnosis on the quality of life of heroin users seeking treatment. ( Astals, M; Buenaventura, CC; Domingo-Salvany, A; Martín-Santos, R; Tato, J; Torrens, M; Vazquez, JM, 2008)
" Severity of psychological distress was related to current substance-related diagnoses, benzodiazepine abuse, higher methadone dosage, risk-taking behavior and the presence of hepatitis C."	3.73	Does psychiatric comorbidity affect drug abuse treatment outcome? A prospective assessment of drug abuse, treatment tenure and infectious diseases in an Israeli methadone maintenance clinic. ( Adelson, M; Bleich, A; Gelkopf, M; Melamed, Y; Weizman, T, 2006)
"Methadone maintenance treatment (MMT) may prevent overdose and death among homeless people with opioid dependence, but suboptimal medication adherence is a common limitation."	2.87	The effect of Housing First on adherence to methadone maintenance treatment. ( Moniruzzaman, A; Parpouchi, M; Rezansoff, SN; Russolillo, A; Somers, JM, 2018)
" Accuracy in MEMS caps openings was customized to each participant's unique required dosing schedule."	2.82	Comparison of methods to assess psychiatric medication adherence in methadone-maintained patients with co-occurring psychiatric disorder. ( Brooner, RK; Dunn, KE; King, VL, 2016)
"Referral of patients with co-occurring psychiatric disorders receiving methadone maintenance to a community psychiatry program is often ineffective, even after reducing common barriers to care."	2.79	Challenges and outcomes of parallel care for patients with co-occurring psychiatric disorder in methadone maintenance treatment. ( Brooner, RK; Kidorf, M; King, VL; Kolodner, K; Peirce, J, 2014)
"Comorbid psychiatric disorders among opioid-dependent patients are associated with several negative outcome factors."	2.75	Effects of psychiatric comorbidity on treatment outcome in patients undergoing diamorphine or methadone maintenance treatment. ( Dilg, C; Eiroa-Orosa, FJ; Haasen, C; Reimer, J; Schäfer, I; Verthein, U, 2010)
"Twelve-week HIV and substance abuse treatment outcomes are reported as a sub-study for those selecting BPN/NLX."	2.75	Improved HIV and substance abuse treatment outcomes for released HIV-infected prisoners: the impact of buprenorphine treatment. ( Altice, FL; Chen, S; Springer, SA, 2010)
"Buprenorphine patients were also less likely than methadone patients to withdraw voluntarily from medication while in jail (3% vs."	2.74	Buprenorphine and methadone maintenance in jail and post-release: a randomized clinical trial. ( Hershberger, J; Joseph, H; Lee, JD; Magura, S; Marsch, L; Rosenblum, A; Shropshire, C, 2009)
"Axis I and II psychiatric diagnosis was assessed and methadone dosage and history of abuse was recorded."	2.71	Treatment of benzodiazepine dependence in methadone maintenance treatment patients: a comparison of two therapeutic modalities and the role of psychiatric comorbidity. ( Adelson, M; Bleich, A; Gelkopf, M; Melamed, Y; Weizman, T, 2003)
"Psychiatric disorders have become an increasing concern in the treatment of substance abusers."	2.67	Psychiatric disorders of opioid addicts entering treatment: preliminary data. ( Abbott, PJ; Walker, SR; Weller, SB, 1994)
"Four groups were compared: those with opiate dependence alone (N = 16); opiate dependence plus depression (N = 16); opiate dependence plus depression plus antisocial personality disorder (N = 17); and opiate dependence plus antisocial personality disorder (N = 13)."	2.66	Sociopathy and psychotherapy outcome. ( Luborsky, L; McLellan, AT; O'Brien, CP; Woody, GE, 1985)
"Management of patients with opioid use disorder (OUD) commonly includes opioid agonist therapy (OAT) as a part of an integrated treatment plan."	2.55	Recommendations for buprenorphine and methadone therapy in opioid use disorder: a European consensus. ( Alam, F; Alho, H; Auriacombe, M; Benyamina, A; Bobes, J; D'Agnone, O; Daulouede, JP; Dematteis, M; Leonardi, C; Littlewood, R; Maremmani, I; Somaini, L; Soyka, M; Szerman, N; Torrens, M; Walcher, S, 2017)
"Etravirine (ETR) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with a potent and broad in vitro spectrum of activity against HIV-1 and viruses with NNRTI resistances, allowing sequential use of drugs of this family."	2.45	[Etravirine in first-line therapy]. ( Garcés, PA; Tena, EV, 2009)
"Methadone maintenance treatment (MMT) has been the 'gold standard' pharmacotherapy treatment for illicit opioid dependence for over 30 years."	2.43	Eyes wide shut?--A conceptual and empirical critique of methadone maintenance treatment. ( Fischer, B; Kim, G; Kirst, M; Rehm, J, 2005)
"Treatment of cocaine addiction includes anti-craving agents, dopamine agonists or blocking agents, antidepressants, and treatment of co-morbid psychiatric disorders, but all with mixed results."	2.42	Pharmacologic treatments for heroin and cocaine dependence. ( Kleber, HD, 2003)
"Methadone maintenance treatment programs have been shown to decrease criminal behavior, improve psychosocial functioning, and decrease injecting narcotic use, thus reducing the spread of AIDS."	2.39	Methadone maintenance treatment. When and how to refer patients. ( DeMaria, PA; Weinstein, SP, 1995)
"A total of 246 (52."	1.56	Comparison of psychiatric comorbidity in treatment-seeking, opioid-dependent patients with versus without chronic pain. ( Higgins, C; Matthews, K; Smith, BH, 2020)
"Although homelessness and opioid use disorder (OUD) are important public health issues, few studies have examined their cooccurrence."	1.56	Correlates of Homelessness Among Patients in Methadone Maintenance Treatment. ( Barry, DT; Beitel, M; Gaeta, M; Madden, LM; Oberleitner, DE; Oberleitner, LMS; Tamberelli, JF, 2020)
"Methadone Maintenance Treatment (MMT) is utilized by an increasingly broad age-range of individuals with opioid use disorders."	1.48	Characteristics of Medicaid recipients in Methadone Maintenance Treatment: A comparison across the lifespan. ( Brooks, JM; Bruce, ML; Bryson, WC; Cotton, BP; Lohman, MC, 2018)
"Methadone dosages were recorded among heroin-dependent patients on maintenance treatment."	1.43	Sexual Dysfunction in Men Receiving Methadone Maintenance Treatment: Clinical History and Psychobiological Correlates. ( Donnini, C; Gerra, G; Leonardi, C; Manfredini, M; Maremmani, I; Somaini, L, 2016)
"The detection of psychiatric disorders and provision of appropriate treatment is needed to improve the quality of life of patients on MMT."	1.43	Psychiatric comorbidity among patients on methadone maintenance therapy and its influence on quality of life. ( Habil, MH; Teoh Bing Fei, J; Yee, A, 2016)
"We found a rise in possible mental illness in both subpopulations in the study period."	1.43	Psychiatric disorders are overlooked in patients with drug abuse. ( Banner, J; Kruckow, L; Linnet, K, 2016)
"The effectiveness of methadone maintenance treatment is beyond any doubt, but there remains some incertitude about the appropriate and effective dosage and the objectives that should be achieved by this therapy."	1.43	Methadone dosage and its relationship to quality of life, satisfaction, psychopathology, cognitive performance and additional consumption of non-prescribed drugs. ( MethaQoL, G; Pedrero-Pérez, EJ, 2016)
"Compared to patients without serious mental illness, patients with serious mental illness in methadone maintenance treatment were more likely to have been homeless, to have had a recent psychiatric hospitalization, to be over 50% disabled, and to have had more fills for more classes of psychotropic drugs."	1.42	Psychiatric services and prescription fills among veterans with serious mental illness in methadone maintenance treatment. ( Marienfeld, C; Rosenheck, RA, 2015)
"Lifetime psychiatric diagnosis was assessed according to DSM-IV-TR (Axis I, II, I & II, or none)."	1.40	Impact of lifetime psychiatric diagnosis on long-term retention and survival of former opiate addicts in methadone maintenance treatment. ( Adelson, M; Domany, Y; Peles, E; Schreiber, S, 2014)
"Sudden cardiac death was recorded in five patients, and torsade de pointes was recorded in seven other patients."	1.39	Drug-induced long QT in adult psychiatric inpatients: the 5-year cross-sectional ECG Screening Outcome in Psychiatry study. ( Berney, P; Dayer, P; Gaspoz, JM; Gex-Fabry, M; Girardin, FR; Shah, D, 2013)
" Patients with additional heroin intake over the past 30 days had been treated with a significantly lower L-methadone dosage (P<0."	1.36	Psychiatric comorbidity and additional abuse of drugs in maintenance treatment with L- and D,L-methadone. ( Baumann, P; Cimander, K; Havemann-Reinecke, U; Jacobs, S; Karg, I; Luedecke, C; Poser, W; Ruether, E; Schneider, U; Wedekind, D, 2010)
"We assess the influence of co-occurring psychiatric disorders on retention in 189 opioid dependent patients in a methadone maintenance treatment (MMT) and determine the incidence of psychiatric co-morbidity during an 18-month follow-up period."	1.35	Impact of co-occurring psychiatric disorders on retention in a methadone maintenance program: an 18-month follow-up study. ( Astals, M; Bulbena, A; Díaz, L; Domingo-Salvany, A; Martín-Santos, R; Torrens, M, 2009)
"Recent clinical studies suggest that substance use may be associated with an acceleration of the ageing process, possibly related to a deficit of stem cell number or function."	1.35	An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey. ( Reece, AS, 2008)
"The causes of death were blunt trauma (n = 206) and electrocution (n = 5)."	1.35	Subway train-related fatalities in New York City: accident versus suicide. ( Gill, JR; Lin, PT, 2009)
"Engagement in substance abuse treatment was not associated with a decrease in hospital use by HIV-infected individuals with a history of alcohol problems."	1.33	Substance abuse treatment and hospitalization among a cohort of HIV-infected individuals with alcohol problems. ( Horton, NJ; Meli, S; Palepu, A; Samet, JH; Tibbetts, N, 2005)
"The methadone patients were followed up to 1998 with respect to being expelled from treatment."	1.32	Leaving methadone maintenance treatment: the role of personality traits and psychiatric status. ( Brandt, L; Lettholm, L; Stenbacka, M, 2004)
"Preexisting psychiatric disorders or present methadone substitution should no longer be regarded as contraindications to treatment of chronic hepatitis C with IFN-alpha and ribavirin in an interdisciplinary setting."	1.32	Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups. ( Folwaczny, C; Grunze, H; Heldwein, W; Koenig, A; Loeschke, K; Lorenz, R; Martin, G; Schaefer, M; Schindlbeck, N; Schmidt, F; Soyka, M, 2003)
" The effects of this compound are probably more favorable when combined with a psychosocial intervention such as the Community Reinforcement Approach (CRA)."	1.32	Experiences with an outpatient relapse program (community reinforcement approach) combined with naltrexone in the treatment of opioid-dependence: effect on addictive behaviors and the predictive value of psychiatric comorbidity. ( Kerkhof, AJ; Roozen, HG; van den Brink, W, 2003)
"Comorbid psychiatric disorders did not appear to influence methadone effectiveness, but psychopharmacological treatment associated with methadone was associated with a lower rate of urine samples positive for drug use."	1.32	Long-term methadone maintenance effectiveness: psychosocial and pharmacological variables. ( Ferri, M; Gerra, G; Polidori, E; Santoro, G; Sternieri, E; Zaimovic, A, 2003)
"Participants were opioid abusers entering methadone treatment."	1.31	Influence of psychiatric comorbidity on HIV risk behaviors: changes during drug abuse treatment. ( Brooner, RK; Kidorf, MS; King, VL; Stoller, KB, 2000)
"Across substance use and psychosocial domains, participants showed significant and comparable levels of improvement regardless of comorbidity."	1.31	The relationship of psychiatric comorbidity to treatment outcomes in methadone maintained patients. ( Alterman, AI; Cacciola, JS; McKay, JR; Mulvaney, FD; Rutherford, MJ, 2001)
"In 71% of the group who had a comorbid psychiatric illness, the onset of psychiatric symptomatology was reported to predate the use of heroin."	1.31	Prevalence of psychiatric disorder in a methadone maintenance population. ( Callaly, T; Munro, L; Trauer, T; Whelan, G, 2001)
"Psychiatric and substance use comorbidity was assessed in 716 opioid abusers seeking methadone maintenance."	1.30	Psychiatric and substance use comorbidity among treatment-seeking opioid abusers. ( Bigelow, GE; Brooner, RK; Kidorf, M; King, VL; Schmidt, CW, 1997)
"Women with ASPD were unlikely to have alcohol use disorder, but likely to have opioid use disorder."	1.30	Gender differences in psychiatric comorbidity among cocaine-using opiate addicts. ( Foote, J; Handelsman, L; Kang, SY; Magura, S; Rosenblum, A, 1998)
"Diagnosing comorbid psychiatric disorders in methadone maintained patients may help to identify subgroups with different outcomes and needs for treatment."	1.30	Psychiatric comorbidity in methadone maintained patients. ( Borg, L; Khuri, ET; Kocsis, JH; Kreek, MJ; Mason, BJ; Melia, D; Millman, RB; Sweeney, J; Wells, A, 1998)
"Providing health services to drug abuse treatment clients improves their outcomes."	1.30	On-site primary care and mental health services in outpatient drug abuse treatment units. ( Alexander, JA; D'Aunno, TA; Friedmann, PD; Jin, L, 1999)
"The implications of study findings for AIDS prevention programming are discussed."	1.29	Psychological dysfunction and HIV/AIDS risk behavior. ( Brown, BS; Camacho, LM; Simpson, DD, 1996)
"Axis I nonsubstance use disorder was associated with benzodiazepine use, while Axis II disorder was associated with both benzodiazepine and cocaine use early in treatment (P < 0."	1.29	Concurrent validity of cocaine and sedative dependence diagnoses in opioid-dependent outpatients. ( Brooner, RK; Chutuape, MA; Kidorf, M; King, VL; Stitzer, ML, 1996)
"Many substance abusers present with elevated scores on self-report measures of psychopathological symptoms."	1.29	Psychiatric symptomatology in crack cocaine abusers. ( Gottheil, E; Shannon, DM; Sterling, RC; Weinstein, SP, 1994)
"Multiple substance use disorders were found in these patients, and more substance use disorders were found in those patients with, versus without, a non-substance use psychiatric diagnosis."	1.28	Clustering of multiple substance use and psychiatric diagnoses in opiate addicts. ( Bigelow, GE; Brooner, RK; Strain, EC, 1991)
"The origin of the psychiatric illnesses observed in drug abusers is often unclear."	1.26	Development of psychiatric illness in drug abusers. Possible role of drug preference. ( Mc Lellan, AT; O'Brien, CP; Woody, GE, 1979)
"Commonly diagnosed conditions included drug abuse, psychiatric disorder, trauma, and alcohol abuse."	1.26	Health status of the New York City prison population. ( Loewenstein, R; Novick, LF; Penna, RD; Remmlinger, E; Schwartz, MS, 1977)

Research

Studies (180)

Authors

Clinical Trials (9)

Trial Overview

Trial Outcomes

Number of Opioid-negative Urine Toxicology Tests

Timeframe	Studies, this research(%)	All Research%
pre-1990	29 (16.11)	18.7374
1990's	31 (17.22)	18.2507
2000's	57 (31.67)	29.6817
2010's	54 (30.00)	24.3611
2020's	9 (5.00)	2.80

Authors	Studies
Kalin, NH	1
Peterkin, A	1
Laks, J	1
Weinstein, ZM	1
Tran, HV	2
Filipowicz, TR	2
Landrum, KR	2
Nong, HTT	2
Tran, TTT	2
Pence, BW	2
Go, VF	2
Le, GM	2
Nguyen, MX	2
Verhey, R	2
Chibanda, D	2
Ho, HT	2
Gaynes, BN	2
Alam, F	2
Wright, N	1
Roberts, P	1
Dhadley, S	1
Townley, J	1
Webster, R	1
Wupperman, P	1
Burns, N	1
Pugach, CP	1
Edwards, E	1
Pro, G	1
Utter, J	1
Haberstroh, S	1
Baldwin, JA	1
Andrade, G	1
Simões do Couto, F	1
Câmara-Pestana, L	1
Gaeta, M	1
Beitel, M	5
Oberleitner, LMS	1
Oberleitner, DE	1
Madden, LM	2
Tamberelli, JF	1
Barry, DT	5
Haffajee, RL	1
Andraka-Christou, B	1
Attermann, J	1
Cupito, A	1
Buche, J	1
Beck, AJ	1
Oliveira, C	1
Filipe, R	1
Meira, J	1
Sampaio, L	1
Teixeira, L	1
Rodrigues, J	1
Nunes, I	1
Tavares, J	1
Leone, B	1
Di Nicola, M	1
Moccia, L	1
Pettorruso, M	1
De Risio, L	1
Nucara, G	1
Zamboni, L	2
Callea, A	1
Janiri, L	1
Cibin, M	1
Lugoboni, F	2
Levin, FR	1
Pieri, MC	1
Manfredini, M	3
Somaini, L	4
Gerra, G	5
Sadeghi, S	1
Ekhtiari, H	1
Bahrami, B	1
Ahmadabadi, MN	1
Dematteis, M	1
Auriacombe, M	1
D'Agnone, O	1
Szerman, N	1
Littlewood, R	1
Alho, H	1
Benyamina, A	1
Bobes, J	2
Daulouede, JP	1
Leonardi, C	2
Maremmani, I	8
Torrens, M	4
Walcher, S	1
Soyka, M	3
Parpouchi, M	1
Moniruzzaman, A	1
Rezansoff, SN	1
Russolillo, A	1
Somers, JM	1
Cotton, BP	1
Bryson, WC	1
Lohman, MC	1
Brooks, JM	1
Bruce, ML	1
Lister, JJ	1
Brown, S	1
Greenwald, MK	1
Ledgerwood, DM	1
Higgins, C	1
Smith, BH	1
Matthews, K	1
Taplin, S	1
Mattick, RP	2
Brooner, RK	10
Kidorf, MS	3
King, VL	8
Peirce, J	3
Neufeld, K	1
Stoller, K	1
Kolodner, K	2
Savant, JD	1
Cutter, CJ	3
Peters, S	1
Belisle, N	1
Webster, LR	1
Ling, W	1
Jones, HE	1
Deppen, K	1
Hudak, ML	1
Leffert, L	1
McClelland, C	1
Sahin, L	1
Starer, J	1
Terplan, M	1
Thorp, JM	1
Walsh, J	1
Creanga, AA	1
Specka, M	1
Lopez Gonzales, K	1
Scherbaum, N	2
Girardin, FR	1
Gex-Fabry, M	1
Berney, P	1
Shah, D	1
Gaspoz, JM	1
Dayer, P	1
Fodor, A	1
Tímár, J	1
Zelena, D	1
Kidorf, M	4
Peles, E	4
Schreiber, S	4
Domany, Y	1
Adelson, M	6
Gandotra, N	1
Ghazarian, S	1
Linzy, S	1
Domani, Y	1
Arends, MT	1
De Haan, HA	1
Van 't Hoff, GI	1
Marienfeld, C	1
Rosenheck, RA	1
Roncero, C	2
Domínguez-Hernández, R	1
Díaz, T	1
Fernández, JM	1
Forcada, R	1
Martínez, JM	1
Seijo, P	1
Terán, A	1
Oyagüez, I	1
Donnini, C	2
Cernovsky, Z	1
Sadek, G	1
Chiu, S	1
Teoh Bing Fei, J	1
Yee, A	1
Habil, MH	1
Stults-Kolehmainen, M	1
Schottenfeld, RS	3
Eggert, K	1
Kerns, RD	2
Liong, C	2
Ginn, J	1
Dunn, KE	1
Kruckow, L	1
Linnet, K	1
Banner, J	1
Krebs, E	1
Kerr, T	1
Wood, E	1
Nosyk, B	1
Pedrero-Pérez, EJ	1
MethaQoL, G	1
Barral, C	1
Rodríguez-Cintas, L	1
Pérez-Pazos, J	1
Martinez-Luna, N	1
Casas, M	1
Grau-López, L	1
Pacini, M	4
Lubrano, S	1
Perugi, G	3
Tagliamonte, A	2
Pani, PP	4
Shinderman, M	3
Morgenstern, J	1
Hogue, A	1
Dasaro, C	1
Kuerbis, A	1
Dauber, S	1
Winklbaur, B	1
Kopf, N	1
Ebner, N	1
Jung, E	1
Thau, K	1
Fischer, G	1
Magura, S	3
Lee, JD	1
Hershberger, J	1
Joseph, H	2
Marsch, L	1
Shropshire, C	1
Rosenblum, A	3
Reece, AS	2
Davstad, I	1
Stenbacka, M	2
Leifman, A	1
Romelsjö, A	1
Garnet, B	1
Joshi, D	1
Chast, F	1
Lin, PT	1
Gill, JR	1
Astals, M	2
Díaz, L	1
Domingo-Salvany, A	2
Martín-Santos, R	2
Bulbena, A	1
Schäfer, I	1
Eiroa-Orosa, FJ	1
Verthein, U	2
Dilg, C	1
Haasen, C	1
Reimer, J	2
Garcés, PA	1
Tena, EV	1
Springer, SA	1
Chen, S	1
Altice, FL	1
Wedekind, D	1
Jacobs, S	1
Karg, I	1
Luedecke, C	1
Schneider, U	1
Cimander, K	1
Baumann, P	1
Ruether, E	1
Poser, W	1
Havemann-Reinecke, U	1
Ngo, HT	1
Tait, RJ	1
Hulse, GK	1
Batki, SL	1
Canfield, KM	1
Smyth, E	1
Ploutz-Snyder, R	1
Levine, RA	1
Carpentier, PJ	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407]		55 participants (Actual)	Interventional	2017-04-20	Completed
Services Research: Psychiatric Comorbidity in Drug Abuse[NCT00787735]		380 participants (Actual)	Interventional	2004-01-31	Completed
Chronic Pain and Opioid Dependence Assessment and Treatment[NCT00727675]		15 participants (Actual)	Interventional	2008-08-31	Completed
Clinical Trial of Integrated Treatment for Pain and Opioid Dependence[NCT00634803]	Phase 1/Phase 2	90 participants (Actual)	Interventional	2009-09-30	Completed
Directly Observed Therapy for Community-Released HIV+ Prisoners[NCT00786396]		151 participants (Actual)	Interventional	2004-07-31	Completed
Treatment of Chronic Hepatitis c With Interferon-Alpha 2a and Ribavirin: a Comparison of Patients With Psychiatric Disorders and Controls[NCT00751426]		81 participants (Actual)	Observational	1999-08-31	Completed
Amantadine for Neuroenhancement in Acute Patients Study - A Prospective Pilot Proof of Concept Phase IIb Study in Intensive and Intermediate Care Unit Patients[NCT05479032]	Phase 2	50 participants (Anticipated)	Interventional	2022-09-30	Not yet recruiting
A Prospective Cohort Study Comparing the Effectiveness of Zepatier for the Treatment of Hepatitis C in an Academic Center Population to People Who Inject Drugs (PWIDs) in a Safety Net Clinic Setting Engaged in Either a Medication Assisted Therapy (MAT) or[NCT03093415]	Phase 4	100 participants (Actual)	Interventional	2017-05-30	Completed
A Randomized Community Intervention Trial on Reducing HIV Infection Among Drug Users Attending Methadone Maintenance Treatment(MMT) and Preventing Secondary Transmission From HIV Positive Clients to Their Sexual Partners in China[NCT01108614]	Phase 3	12,000 participants (Anticipated)	Interventional	2009-06-30	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Reduced illicit opioid use is defined as the number of documented opioid negative urine tests in each of the time periods.This measures the reduction in illicit opioid use - more opioid-negative tests means greater reductions in illicit opioid use. The highest possible score is 4- which would indicate 4 negative urine tests during the assessment period. Originally titled Reduced illicit opioid use and the timeframe was listed as 16 weeks." (NCT00634803)
Timeframe: 3 Months

Pain Intensity

Intervention	opioid negative urine tests (Mean)
	Intake/Induction	Month 1	Month 2	Month 3
CBT for POD	0.67	2.67	2.96	2.80
Educational Counseling for POD	0.67	2.80	3.30	3.25
Physician Management	0.55	2.48	2.56	2.04

Pain intensity comprises the average of 4 items related to current pain and past-week average pain, pain at its worst, and pain at its least. Pain intensity is scored on 0-10 scale (average score ranges from 0-10), where higher scores indicate higher pain intensity.Originally labeled as Pain Reduction at 16 weeks- 3 months was the correct timeframe. (NCT00634803)
Timeframe: 3 months

Pain Interference

Intervention	units on a scale (Mean)
	Intake/Induction	Month 1	Month 2	Month 3
CBT for POD	5.43	4.75	4.79	4.41
Educational Counseling for POD	5.92	5.02	4.98	4.62
Physician Management	5.28	4.53	4.72	4.84

Pain interference comprises the average of 7 items related to past-week pain-related interference in general activity, walking, work, mood, enjoyment of life, relations with others, and sleep. Each item is scored on a 0-10 scale (averaged 0-10), where higher scores indicate higher pain interference. (NCT00634803)
Timeframe: 3 Months

Intervention	units on a scale (Mean)
	Intake/Induction	Month 1	Month 2	Month 3
CBT for POD	5.75	4.15	4.08	3.22
Educational Counseling for POD	5.48	3.74	3.61	3.23
Physician Management	5.01	3.32	3.45	3.87

Article	Year
Current Best Practices for Acute and Chronic Management of Patients with Opioid Use Disorder. The Medical clinics of North America, 2022, Volume: 106, Issue:1 Topics: Adult; Analgesics, Opioid; Buprenorphine; Comorbidity; Disease Management; Drug Overdose; Female; Fe	2022
[Recommendations about the Use of Psychotropic Medications during the COVID-19 Pandemic]. Acta medica portuguesa, 2020, Oct-01, Volume: 33, Issue:10 Topics: Antiviral Agents; Benzodiazepines; Betacoronavirus; Bipolar Disorder; Body Temperature Regulation; B	2020
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Behavioral effects of perinatal opioid exposure. Life sciences, 2014, May-28, Volume: 104, Issue:1-2 Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Female; Humans; Illicit Drugs; Infant, Ne	2014
Treating pregnant women dependent on opioids is not the same as treating pregnancy and opioid dependence: a knowledge synthesis for better treatment for women and neonates. Addiction (Abingdon, England), 2008, Volume: 103, Issue:9 Topics: Buprenorphine; Diagnosis, Dual (Psychiatry); Female; GABA Modulators; Humans; Infant, Newborn; Menta	2008
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[Etravirine in first-line therapy]. Enfermedades infecciosas y microbiologia clinica, 2009, Volume: 27 Suppl 2 Topics: Anti-HIV Agents; Chemical and Drug Induced Liver Injury; Drug Eruptions; Drug Interactions; Drug Res	2009
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Management of opioid substitution therapy during medical intervention. Internal medicine journal, 2012, Volume: 42, Issue:3 Topics: Analgesics; Australia; Buprenorphine; Comorbidity; Drug Interactions; Female; Humans; Liver Diseases	2012
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Eyes wide shut?--A conceptual and empirical critique of methadone maintenance treatment. European addiction research, 2005, Volume: 11, Issue:1 Topics: Comorbidity; Humans; Illicit Drugs; Long-Term Care; Mental Disorders; Methadone; Opioid-Related Diso	2005
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Hepatitis C virus infection and injection drug users: prevention, risk factors, and treatment. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2005, Apr-15, Volume: 40 Suppl 5 Topics: Adult; Delivery of Health Care; Female; Genotype; Germany; Health Planning Guidelines; Hepatitis C;	2005
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Stigma experienced by people living with HIV who are on methadone maintenance treatment and have symptoms of common mental disorders in Hanoi, Vietnam: a qualitative study. AIDS research and therapy, 2022, 12-14, Volume: 19, Issue:1 Topics: HIV Infections; Humans; Mental Disorders; Methadone; Qualitative Research; Social Stigma; Substance-	2022
Stigma experienced by people living with HIV who are on methadone maintenance treatment and have symptoms of common mental disorders in Hanoi, Vietnam: a qualitative study. AIDS research and therapy, 2022, 12-14, Volume: 19, Issue:1 Topics: HIV Infections; Humans; Mental Disorders; Methadone; Qualitative Research; Social Stigma; Substance-	2022
Stigma experienced by people living with HIV who are on methadone maintenance treatment and have symptoms of common mental disorders in Hanoi, Vietnam: a qualitative study. AIDS research and therapy, 2022, 12-14, Volume: 19, Issue:1 Topics: HIV Infections; Humans; Mental Disorders; Methadone; Qualitative Research; Social Stigma; Substance-	2022
Stigma experienced by people living with HIV who are on methadone maintenance treatment and have symptoms of common mental disorders in Hanoi, Vietnam: a qualitative study. AIDS research and therapy, 2022, 12-14, Volume: 19, Issue:1 Topics: HIV Infections; Humans; Mental Disorders; Methadone; Qualitative Research; Social Stigma; Substance-	2022
The effect of Housing First on adherence to methadone maintenance treatment. The International journal on drug policy, 2018, Volume: 56 Topics: Adult; Community Mental Health Services; Drug Overdose; Female; Housing; Humans; Ill-Housed Persons;	2018
Managing psychiatric comorbidity within versus outside of methadone treatment settings: a randomized and controlled evaluation. Addiction (Abingdon, England), 2013, Volume: 108, Issue:11 Topics: Adult; Ambulatory Care; Baltimore; Comorbidity; Delivery of Health Care, Integrated; Female; Humans;	2013
Challenges and outcomes of parallel care for patients with co-occurring psychiatric disorder in methadone maintenance treatment. Journal of dual diagnosis, 2014, Volume: 10, Issue:2 Topics: Adult; Community Health Services; Female; Humans; Male; Mental Disorders; Methadone; Opiate Substitu	2014
Substance use and response to psychiatric treatment in methadone-treated outpatients with comorbid psychiatric disorder. Journal of substance abuse treatment, 2015, Volume: 51 Topics: Adult; Diagnosis, Dual (Psychiatry); Female; Humans; Male; Mental Disorders; Methadone; Middle Aged;	2015
Comparison of methods to assess psychiatric medication adherence in methadone-maintained patients with co-occurring psychiatric disorder. Drug and alcohol dependence, 2016, Mar-01, Volume: 160 Topics: Adult; Analgesics, Opioid; Comorbidity; Diagnosis, Dual (Psychiatry); Drug Monitoring; Female; Human	2016
Buprenorphine and methadone maintenance in jail and post-release: a randomized clinical trial. Drug and alcohol dependence, 2009, Jan-01, Volume: 99, Issue:1-3 Topics: Adolescent; Adult; Aged; Buprenorphine; Diagnosis, Dual (Psychiatry); Female; Follow-Up Studies; HIV	2009
Effects of psychiatric comorbidity on treatment outcome in patients undergoing diamorphine or methadone maintenance treatment. Psychopathology, 2010, Volume: 43, Issue:2 Topics: Adult; Case Management; Combined Modality Therapy; Comorbidity; Diagnosis, Dual (Psychiatry); Female	2010
Improved HIV and substance abuse treatment outcomes for released HIV-infected prisoners: the impact of buprenorphine treatment. Journal of urban health : bulletin of the New York Academy of Medicine, 2010, Volume: 87, Issue:4 Topics: Anti-Retroviral Agents; Buprenorphine; Buprenorphine, Naloxone Drug Combination; CD4 Lymphocyte Coun	2010
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A stage I pilot study of acceptance and commitment therapy for methadone detoxification. Drug and alcohol dependence, 2012, Oct-01, Volume: 125, Issue:3 Topics: Adult; Counseling; Diagnostic and Statistical Manual of Mental Disorders; Fear; Female; Humans; Inac	2012
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Insights Into Improving Clinical Outcomes Across Psychiatric Disorders and Medical Comorbidities. The American journal of psychiatry, 2021, 09-01, Volume: 178, Issue:9 Topics: Alcoholism; Anorexia Nervosa; Attention Deficit Disorder with Hyperactivity; Comorbidity; Humans; Me	2021
Optimising opioid substitution therapy in the prison environment. International journal of prisoner health, 2019, 12-05, Volume: 15, Issue:4 Topics: Age Factors; Buprenorphine; Comorbidity; Continuity of Patient Care; Delayed-Action Preparations; Dr	2019
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Sexual Dysfunction in Men Receiving Methadone Maintenance Treatment: Clinical History and Psychobiological Correlates. European addiction research, 2016, Volume: 22, Issue:3 Topics: Adult; Adult Survivors of Child Abuse; Case-Control Studies; Comorbidity; Diagnosis, Dual (Psychiatr	2016
SELF-REPORTS OF ILLEGAL ACTIVITY, SCL-90-R PERSONALITY SCALES, AND URINE TESTS IN METHADONE PATIENTS. Psychological reports, 2015, Volume: 117, Issue:3 Topics: Adult; Canada; Checklist; Cocaine; Crime; Female; Humans; Male; Mental Disorders; Methadone; Middle	2015
Psychiatric comorbidity among patients on methadone maintenance therapy and its influence on quality of life. The American journal on addictions, 2016, Volume: 25, Issue:1 Topics: Adult; Analgesics, Opioid; Antisocial Personality Disorder; Comorbidity; Humans; Malaysia; Male; Men	2016
Physical activity, psychiatric distress, and interest in exercise group participation among individuals seeking methadone maintenance treatment with and without chronic pain. The American journal on addictions, 2016, Volume: 25, Issue:2 Topics: Adult; Chronic Pain; Exercise; Female; Humans; Male; Mental Disorders; Methadone; Middle Aged; Opiat	2016
Psychiatric disorders are overlooked in patients with drug abuse. Danish medical journal, 2016, Volume: 63, Issue:3 Topics: Adult; Analgesics, Opioid; Cause of Death; Denmark; Diagnosis, Dual (Psychiatry); Drug Users; Female	2016
Characterizing Long-Term Health Related Quality of Life Trajectories of Individuals With Opioid Use Disorder. Journal of substance abuse treatment, 2016, Volume: 67 Topics: Adult; Cohort Studies; Disabled Persons; Female; Follow-Up Studies; Humans; Longitudinal Studies; Ma	2016
Methadone dosage and its relationship to quality of life, satisfaction, psychopathology, cognitive performance and additional consumption of non-prescribed drugs. Adicciones, 2016, Jun-14, Volume: 29, Issue:1 Topics: Cognition; Female; Humans; Male; Mental Disorders; Methadone; Middle Aged; Narcotics; Nonprescriptio	2016
Psychiatric comorbidities in opioid-dependent patients undergoing a replacement therapy programme in Spain: The PROTEUS study. Psychiatry research, 2016, Sep-30, Volume: 243 Topics: Adult; Comorbidity; Diagnosis, Dual (Psychiatry); Female; Humans; Male; Mental Disorders; Methadone;	2016
Psychiatric Disorders Among Patients Seeking Treatment for Co-Occurring Chronic Pain and Opioid Use Disorder. The Journal of clinical psychiatry, 2016, Volume: 77, Issue:10 Topics: Adult; Buprenorphine; Chronic Pain; Comorbidity; Cross-Sectional Studies; Disability Evaluation; Fem	2016
Psychiatric Disorders Among Patients Seeking Treatment for Co-Occurring Chronic Pain and Opioid Use Disorder. The Journal of clinical psychiatry, 2016, Volume: 77, Issue:10 Topics: Adult; Buprenorphine; Chronic Pain; Comorbidity; Cross-Sectional Studies; Disability Evaluation; Fem	2016
Psychiatric Disorders Among Patients Seeking Treatment for Co-Occurring Chronic Pain and Opioid Use Disorder. The Journal of clinical psychiatry, 2016, Volume: 77, Issue:10 Topics: Adult; Buprenorphine; Chronic Pain; Comorbidity; Cross-Sectional Studies; Disability Evaluation; Fem	2016
Psychiatric Disorders Among Patients Seeking Treatment for Co-Occurring Chronic Pain and Opioid Use Disorder. The Journal of clinical psychiatry, 2016, Volume: 77, Issue:10 Topics: Adult; Buprenorphine; Chronic Pain; Comorbidity; Cross-Sectional Studies; Disability Evaluation; Fem	2016
Long-term outcomes of treatment-resistant heroin addicts with and without DSM-IV axis I psychiatric comorbidity (dual diagnosis). European addiction research, 2008, Volume: 14, Issue:3 Topics: Adult; Catchment Area, Health; Cohort Studies; Comorbidity; Demography; Diagnosis, Dual (Psychiatry)	2008
Characteristics of individuals screening positive for substance use in a welfare setting: implications for welfare and substance-use disorders treatment systems. Journal of studies on alcohol and drugs, 2008, Volume: 69, Issue:4 Topics: Adult; Child; Child Welfare; Comorbidity; Disability Evaluation; Educational Status; Female; Health	2008
An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey. British dental journal, 2008, Dec-13, Volume: 205, Issue:11 Topics: Adolescent; Adult; Aggression; Aging; Alcohol Drinking; Amphetamine-Related Disorders; Anxiety; Atte	2008
An 18-year follow-up of patients admitted to methadone treatment for the first time. Journal of addictive diseases, 2009, Volume: 28, Issue:1 Topics: Adolescent; Adult; Cause of Death; Criminology; Diagnosis, Dual (Psychiatry); Female; Follow-Up Stud	2009
Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients. The Journal of clinical psychiatry, 2009, Volume: 70, Issue:9 Topics: Adult; Chronic Disease; Comorbidity; Connecticut; Female; Humans; Male; Mental Disorders; Methadone;	2009
Subway train-related fatalities in New York City: accident versus suicide. Journal of forensic sciences, 2009, Volume: 54, Issue:6 Topics: Accidents; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Antidepressive Agents; Benz	2009
Impact of co-occurring psychiatric disorders on retention in a methadone maintenance program: an 18-month follow-up study. International journal of environmental research and public health, 2009, Volume: 6, Issue:11 Topics: Adult; Analgesics, Opioid; Antisocial Personality Disorder; Borderline Personality Disorder; Confide	2009
Psychiatric comorbidity and additional abuse of drugs in maintenance treatment with L- and D,L-methadone. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2010, Volume: 11, Issue:2 Pt 2 Topics: Adult; Analgesics, Opioid; Female; Heroin Dependence; Humans; Male; Mental Disorders; Methadone; Mid	2010
Hospital psychiatric comorbidity and its role in heroin dependence treatment outcomes using naltrexone implant or methadone maintenance. Journal of psychopharmacology (Oxford, England), 2011, Volume: 25, Issue:6 Topics: Adult; Australia; Diagnosis, Dual (Psychiatry); Drug Implants; Female; Heroin Dependence; Hospitaliz	2011
Hepatitis C treatment eligibility and comorbid medical illness in methadone maintenance (MMT) and non-MMT patients: a case-control study. Journal of addictive diseases, 2010, Volume: 29, Issue:3 Topics: Adult; Case-Control Studies; Comorbidity; Cross-Sectional Studies; Eligibility Determination; Female	2010
Influence of attention deficit hyperactivity disorder and conduct disorder on opioid dependence severity and psychiatric comorbidity in chronic methadone-maintained patients. European addiction research, 2011, Volume: 17, Issue:1 Topics: Adult; Attention Deficit Disorder with Hyperactivity; Comorbidity; Conduct Disorder; Female; Humans;	2011
Main reasons for hospital admissions by women with a history of methadone maintenance. Drug and alcohol review, 2010, Volume: 29, Issue:6 Topics: Adolescent; Adult; Comorbidity; Female; Hospitalization; Humans; Mental Disorders; Methadone; Middle	2010
Effect of psychiatric severity on the outcome of methadone maintenance treatment. European addiction research, 2011, Volume: 17, Issue:2 Topics: Adult; Cocaine; Cohort Studies; Female; Heroin; Humans; Male; Mental Disorders; Methadone; Opiate Su	2011
Differing age related trajectories of dysfunction in several organ systems in opiate dependence. Aging clinical and experimental research, 2012, Volume: 24, Issue:1 Topics: Adult; Aged; Aging; Aging, Premature; Analgesics, Opioid; Disease Progression; Female; Hair Color; H	2012
Clinical characteristics and risk behavior as a function of HIV status among heroin users enrolled in methadone treatment in northern Taiwan. Substance abuse treatment, prevention, and policy, 2011, Apr-08, Volume: 6 Topics: Adult; Dose-Response Relationship, Drug; Female; Hepatitis C; Heroin Dependence; HIV Seronegativity;	2011
Gender differences in physical and mental health outcomes among an aging cohort of individuals with a history of heroin dependence. Addictive behaviors, 2012, Volume: 37, Issue:3 Topics: Adult; Aged; Aging; California; Female; Follow-Up Studies; Health Status; Heroin Dependence; Humans;	2012
Housing First for severely mentally ill homeless methadone patients. Journal of addictive diseases, 2012, Volume: 31, Issue:3 Topics: Adult; Analgesics, Opioid; Community Mental Health Services; Diagnosis, Dual (Psychiatry); Female; H	2012
Low incidence of adverse events following varenicline initiation among opioid dependent smokers with comorbid psychiatric illness. Drug and alcohol dependence, 2013, Sep-01, Volume: 132, Issue:1-2 Topics: Benzazepines; Cardiovascular Diseases; Comorbidity; Data Interpretation, Statistical; Female; Humans	2013
[Characteristics of heroin dependent patients admitted to a methadone treatment program]. Medicina clinica, 2014, Jan-21, Volume: 142, Issue:2 Topics: Adolescent; Adult; Comorbidity; Cross-Sectional Studies; Educational Status; Female; Hepatitis B, Ch	2014
Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups. Hepatology (Baltimore, Md.), 2003, Volume: 37, Issue:2 Topics: Adult; Alcohol Drinking; Antidepressive Agents; Antiviral Agents; Depression; Female; Hepatitis C, C	2003
Experiences with an outpatient relapse program (community reinforcement approach) combined with naltrexone in the treatment of opioid-dependence: effect on addictive behaviors and the predictive value of psychiatric comorbidity. European addiction research, 2003, Volume: 9, Issue:2 Topics: Adult; Combined Modality Therapy; Community Mental Health Services; Comorbidity; Diagnosis, Dual (Ps	2003
Managing opioid dependence. Comparing buprenorphine with methadone. Canadian family physician Medecin de famille canadien, 2003, Volume: 49 Topics: Buprenorphine; Clinical Trials as Topic; Comorbidity; Humans; Mental Disorders; Meta-Analysis as Top	2003
Long-term methadone maintenance effectiveness: psychosocial and pharmacological variables. Journal of substance abuse treatment, 2003, Volume: 25, Issue:1 Topics: Adult; Comorbidity; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Heroin D	2003
Specialized drug liaison midwife services for pregnant opioid dependent women in Dublin, Ireland. Journal of substance abuse treatment, 2004, Volume: 26, Issue:1 Topics: Adult; Crime; Female; Humans; Infant, Newborn; Ireland; Mental Disorders; Methadone; Midwifery; Narc	2004
Prescription opioid abuse in patients presenting for methadone maintenance treatment. Drug and alcohol dependence, 2004, Feb-07, Volume: 73, Issue:2 Topics: Adult; Comorbidity; Drug Prescriptions; Female; Humans; Male; Mental Disorders; Methadone; Narcotics	2004
Psychiatric and social barriers to HIV medication adherence in a triply diagnosed methadone population. AIDS patient care and STDs, 2003, Volume: 17, Issue:12 Topics: Adult; Anti-HIV Agents; Female; HIV Infections; Humans; Male; Mental Disorders; Methadone; New York	2003
Does pregnancy affect outcome of methadone maintenance treatment? Journal of substance abuse treatment, 2004, Volume: 26, Issue:4 Topics: Adult; Case-Control Studies; Comorbidity; Female; Heroin Dependence; Humans; Mental Disorders; Metha	2004
Comparative drug use and psychosocial profiles of opioid dependents applying for medication versus medication-free treatment. The American journal of drug and alcohol abuse, 2004, Volume: 30, Issue:2 Topics: Adult; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Inactivation, Metaboli	2004
Leaving methadone maintenance treatment: the role of personality traits and psychiatric status. Journal of psychoactive drugs, 2004, Volume: 36, Issue:2 Topics: Adult; Female; Humans; Male; Mental Disorders; Methadone; Opioid-Related Disorders; Patient Dropouts	2004
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Substance abuse treatment and hospitalization among a cohort of HIV-infected individuals with alcohol problems. Alcoholism, clinical and experimental research, 2005, Volume: 29, Issue:3 Topics: Adult; Alcoholism; CD4 Lymphocyte Count; Cohort Studies; Female; Halfway Houses; HIV Infections; Hos	2005
The impact of barriers to hepatitis C virus treatment in recovering heroin users maintained on methadone. Journal of substance abuse treatment, 2005, Volume: 29, Issue:3 Topics: Delivery of Health Care; Female; Hepatitis C; Heroin Dependence; Humans; Male; Mental Disorders; Met	2005
Psychiatric diagnoses in a sample of HIV-infected people of color in methadone treatment. Community mental health journal, 2005, Volume: 41, Issue:4 Topics: Adult; Black or African American; Comorbidity; Diagnostic and Statistical Manual of Mental Disorders	2005
Determinants of health-related quality of life of opiate users at entry to low-threshold methadone programs. European addiction research, 2006, Volume: 12, Issue:2 Topics: Adolescent; Adult; Child Abuse; Child Abuse, Sexual; Cocaine-Related Disorders; Comorbidity; Female;	2006
Neuropsychological impairment among asymptomatic HIV-positive former intravenous drug users. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 2006, Volume: 19, Issue:2 Topics: Adult; Chi-Square Distribution; Heterosexuality; HIV Infections; HIV Seropositivity; Humans; Male; M	2006
Does psychiatric comorbidity affect drug abuse treatment outcome? A prospective assessment of drug abuse, treatment tenure and infectious diseases in an Israeli methadone maintenance clinic. The Israel journal of psychiatry and related sciences, 2006, Volume: 43, Issue:2 Topics: Ambulatory Care; Female; Hepatitis C; HIV Infections; Humans; Israel; Male; Mental Disorders; Methad	2006
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Depression in methadone maintenance treatment patients: rate and risk factors. Journal of affective disorders, 2007, Volume: 99, Issue:1-3 Topics: Adult; Benzodiazepines; Brief Psychiatric Rating Scale; Cocaine; Cocaine-Related Disorders; Comorbid	2007
Remission of psychiatric symptoms among drug misusers after drug dependence treatment. The Journal of nervous and mental disease, 2006, Volume: 194, Issue:11 Topics: Adolescent; Adult; Ambulatory Care; Cohort Studies; Comorbidity; Diagnosis, Dual (Psychiatry); Femal	2006
On-site medical care in methadone maintenance: associations with health care use and expenditures. Journal of substance abuse treatment, 2007, Volume: 32, Issue:2 Topics: Ambulatory Care; Cluster Analysis; Comorbidity; Cost Savings; Delivery of Health Care, Integrated; H	2007
Screening for alcohol use patterns among methadone maintenance patients. The American journal of drug and alcohol abuse, 2007, Volume: 33, Issue:1 Topics: Adult; Alcoholism; Female; Heroin Dependence; Humans; Male; Mass Screening; Mental Disorders; Methad	2007
Alcohol and cocaine use and abuse among opioid addicts engaged in a methadone maintenance treatment program. Journal of addictive diseases, 2007, Volume: 26, Issue:1 Topics: Adolescent; Adult; Alcoholism; Catchment Area, Health; Cocaine-Related Disorders; Demography; Female	2007
Substance use and quality of life over 12 months among buprenorphine maintenance-treated and methadone maintenance-treated heroin-addicted patients. Journal of substance abuse treatment, 2007, Volume: 33, Issue:1 Topics: Adult; Buprenorphine; Cohort Studies; Comorbidity; Diagnosis, Dual (Psychiatry); Female; Follow-Up S	2007
Impact of substance dependence and dual diagnosis on the quality of life of heroin users seeking treatment. Substance use & misuse, 2008, Volume: 43, Issue:5 Topics: Adult; Antisocial Personality Disorder; Borderline Personality Disorder; Comorbidity; Diagnosis, Dua	2008
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Heterogeneity of psychiatric diagnosis in treated opiate addicts. Archives of general psychiatry, 1982, Volume: 39, Issue:2 Topics: Adult; Alcoholism; Anxiety Disorders; Depressive Disorder; Female; Humans; Male; Mental Disorders; M	1982
The significance of alcoholism in treated opiate addicts. The Journal of nervous and mental disease, 1982, Volume: 170, Issue:8 Topics: Adult; Age Factors; Alcoholism; Female; Heroin Dependence; Humans; Life Change Events; Longitudinal	1982
Sustained attention in methadone patients. The International journal of the addictions, 1982, Volume: 17, Issue:8 Topics: Adult; Attention; Employment; Heroin Dependence; Humans; Male; Mental Disorders; Methadone; Reaction	1982
Effects of psychiatric care for dual diagnosis patients treated in a drug dependence clinic. The American journal of drug and alcohol abuse, 1995, Volume: 21, Issue:3 Topics: Adult; Cocaine; Combined Modality Therapy; Diagnosis, Dual (Psychiatry); Humans; Illicit Drugs; Male	1995
Psychological problems and client engagement in methadone treatment. The Journal of nervous and mental disease, 1995, Volume: 183, Issue:11 Topics: Adult; Alcohol Drinking; Comorbidity; Counseling; Female; Humans; Male; Mental Disorders; Methadone;	1995
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[Value and limitations of substitution treatments in the care of drug addicts]. Annales de medecine interne, 1994, Volume: 145 Suppl 3 Topics: Acquired Immunodeficiency Syndrome; Adult; Buprenorphine; France; HIV Infections; HIV Seropositivity	1994
Psychiatric symptomatology in crack cocaine abusers. The Journal of nervous and mental disease, 1994, Volume: 182, Issue:10 Topics: Adult; Ambulatory Care; Comorbidity; Crack Cocaine; Diagnosis, Dual (Psychiatry); Female; Hospitaliz	1994
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Psychological dysfunction and HIV/AIDS risk behavior. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1996, Feb-01, Volume: 11, Issue:2 Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Female; HIV Infections; Humans; Male; Mental	1996
Evidence for response set effects in structured research interviews. The Journal of nervous and mental disease, 1996, Volume: 184, Issue:7 Topics: Adult; Defense Mechanisms; Depressive Disorder; Female; Heroin Dependence; Humans; Male; Malingering	1996
Assessment of object relations and reality testing in methadone patients. The American journal of psychiatry, 1996, Volume: 153, Issue:9 Topics: Adult; Anxiety Disorders; Comorbidity; Depressive Disorder; Female; Heroin Dependence; Humans; Male;	1996
Concurrent validity of cocaine and sedative dependence diagnoses in opioid-dependent outpatients. Drug and alcohol dependence, 1996, Volume: 42, Issue:2 Topics: Adult; Ambulatory Care; Anti-Anxiety Agents; Benzodiazepines; Cocaine; Comorbidity; Diagnosis, Dual	1996
Psychopathology and HIV risk behaviors among injection drug users in and out of treatment. Drug and alcohol dependence, 1996, Dec-02, Volume: 43, Issue:1-2 Topics: Adolescent; Adult; Antisocial Personality Disorder; Comorbidity; Female; Health Knowledge, Attitudes	1996
Psychiatric and substance use comorbidity among treatment-seeking opioid abusers. Archives of general psychiatry, 1997, Volume: 54, Issue:1 Topics: Adolescent; Adult; Antisocial Personality Disorder; Comorbidity; Diagnosis, Dual (Psychiatry); Discr	1997
Validity of the psychopathy checklist-revised in male methadone patients. Drug and alcohol dependence, 1997, Mar-14, Volume: 44, Issue:2-3 Topics: Adolescent; Adult; Antisocial Personality Disorder; Comorbidity; Humans; Male; Mental Disorders; Met	1997
A county survey of mental health services in drug treatment programs. Psychiatric services (Washington, D.C.), 1997, Volume: 48, Issue:7 Topics: Adult; Ambulatory Care; Cross-Sectional Studies; Diagnosis, Dual (Psychiatry); Female; Health Care S	1997
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Gender differences in psychiatric comorbidity among cocaine-using opiate addicts. Journal of addictive diseases, 1998, Volume: 17, Issue:3 Topics: Adult; Alcoholism; Anxiety Disorders; Cocaine-Related Disorders; Comorbidity; Female; Humans; Male;	1998
Psychiatric comorbidity in methadone maintained patients. Journal of addictive diseases, 1998, Volume: 17, Issue:3 Topics: Adolescent; Adult; Combined Modality Therapy; Comorbidity; Diagnosis, Dual (Psychiatry); Female; Her	1998
A pilot study comparing severely and persistently mentally ill opiate-addicted patients in dual-diagnosis treatment with patients in methadone maintenance. The American journal on addictions, 1998,Fall, Volume: 7, Issue:4 Topics: Adult; Comorbidity; Demography; Diagnosis, Dual (Psychiatry); Female; Humans; Male; Mental Disorders	1998
On-site primary care and mental health services in outpatient drug abuse treatment units. The journal of behavioral health services & research, 1999, Volume: 26, Issue:1 Topics: Adolescent; Adult; Aged; Ambulatory Care; Child; Combined Modality Therapy; Cross-Sectional Studies;	1999
Gender differences at admission and follow-up in a sample of methadone maintenance clients. Substance use & misuse, 1999, Volume: 34, Issue:8 Topics: Acquired Immunodeficiency Syndrome; Adult; Comorbidity; Crime; Educational Status; Family Relations;	1999
Attention deficit hyperactivity disorder and treatment outcome in opioid abusers entering treatment. The Journal of nervous and mental disease, 1999, Volume: 187, Issue:8 Topics: Adult; Ambulatory Care; Attention; Attention Deficit Disorder with Hyperactivity; Clonidine; Cogniti	1999
Methadone dose and retention during treatment of heroin addicts with Axis I psychiatric comorbidity. Journal of addictive diseases, 2000, Volume: 19, Issue:2 Topics: Adult; Comorbidity; Diagnosis, Dual (Psychiatry); Female; Heroin Dependence; Humans; Male; Mental Di	2000
Changes in Millon Clinical Multiaxial Inventory scores among opiate addicts as a function of retention in methadone maintenance treatment and recent drug use. The American journal of drug and alcohol abuse, 2000, Volume: 26, Issue:2 Topics: Adult; Antisocial Personality Disorder; Anxiety Disorders; Female; Follow-Up Studies; Humans; Male;	2000
Women in treatment: within-gender differences in the clinical presentation of opioid-dependent women. The Journal of nervous and mental disease, 2000, Volume: 188, Issue:10 Topics: Adult; Cluster Analysis; Cohort Studies; Comorbidity; Ethnicity; Female; Health Status; Humans; Lang	2000
Influence of psychiatric comorbidity on HIV risk behaviors: changes during drug abuse treatment. Journal of addictive diseases, 2000, Volume: 19, Issue:4 Topics: Adult; Comorbidity; Female; HIV Infections; Humans; Male; Maryland; Mental Disorders; Methadone; Nar	2000
The relationship of psychiatric comorbidity to treatment outcomes in methadone maintained patients. Drug and alcohol dependence, 2001, Feb-01, Volume: 61, Issue:3 Topics: Adult; Analysis of Variance; Diagnosis, Dual (Psychiatry); Female; Follow-Up Studies; Humans; Male;	2001
Prevalence of psychiatric disorder in a methadone maintenance population. The Australian and New Zealand journal of psychiatry, 2001, Volume: 35, Issue:5 Topics: Adolescent; Adult; Comorbidity; Diagnosis, Dual (Psychiatry); Female; Humans; Male; Mental Disorders	2001
Optimizing long-term response to methadone maintenance treatment: a 152-week follow-up using higher-dose methadone. Journal of addictive diseases, 2002, Volume: 21, Issue:3 Topics: Adult; Comorbidity; Critical Pathways; Dose-Response Relationship, Drug; Female; Follow-Up Studies;	2002
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methadone and Behavior Disorders