methadone and Ataxia
methadone has been researched along with Ataxia in 5 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we report a patient who developed acute bilateral hearing loss, ataxia and paraparesis subsequently to intravenous methadone-abuse." | 4.02 | Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments. ( Haessner, S; Johnen, A; Landmeyer, NC; Meyer Zu Hörste, G; Pawlitzki, M; Repple, J; Schulte-Mecklenbeck, A; Wiendl, H, 2021) |
| " In contrast, identical treatment did not alter the potency of the benzodiazepine alprazolam to induce ataxia." | 3.67 | Modification of the response to opioid and nonopioid drugs by chronic opioid antagonist treatment. ( Inturrisi, CE; Yoburn, BC, 1988) |
| "Development of any ataxia and/or sedation was recorded." | 2.71 | A comparison of the analgesic effects of caudal epidural methadone and lidocaine in the horse. ( Mosing, M; Olbrich, VH, 2003) |
| "The fragile X-associated tremor ataxia syndrome (FXTAS) is caused by the premutation in FMR1 gene." | 1.42 | Methadone use in a male with the FMRI premutation and FXTAS. ( Adams, PE; Faradz, SM; Hagerman, RJ; Lozano, R; Muzar, Z; Schneider, A; Tassone, F, 2015) |
Research
Studies (5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Repple, J | 1 |
| Haessner, S | 1 |
| Johnen, A | 1 |
| Landmeyer, NC | 1 |
| Schulte-Mecklenbeck, A | 1 |
| Pawlitzki, M | 1 |
| Wiendl, H | 1 |
| Meyer Zu Hörste, G | 1 |
| Muzar, Z | 1 |
| Lozano, R | 1 |
| Schneider, A | 1 |
| Adams, PE | 1 |
| Faradz, SM | 1 |
| Tassone, F | 1 |
| Hagerman, RJ | 1 |
| Olbrich, VH | 1 |
| Mosing, M | 1 |
| Yong, RL | 1 |
| Holmes, DT | 1 |
| Sreenivasan, GM | 1 |
| Yoburn, BC | 1 |
| Inturrisi, CE | 1 |
Trials
1 trial available for methadone and Ataxia
| Article | Year |
|---|---|
A comparison of the analgesic effects of caudal epidural methadone and lidocaine in the horse.
Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Animals; Ataxia; Cross-Over Studies; De | 2003 |
Other Studies
4 other studies available for methadone and Ataxia
| Article | Year |
|---|---|
Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments.
Topics: Administration, Intravenous; Analgesics, Opioid; Ataxia; Brain; Brain Diseases; Brain Edema; Cogniti | 2021 |
Methadone use in a male with the FMRI premutation and FXTAS.
Topics: Ataxia; Disease Progression; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Expressi | 2015 |
Aluminum toxicity due to intravenous injection of boiled methadone.
Topics: Adult; Aluminum; Ataxia; Chelation Therapy; Deferoxamine; Dysarthria; Humans; Male; Methadone; Poiso | 2006 |
Modification of the response to opioid and nonopioid drugs by chronic opioid antagonist treatment.
Topics: Alprazolam; Analgesia; Animals; Ataxia; Cocaine; Drug Implants; Kinetics; Male; Methadone; Mice; Mor | 1988 |