Page last updated: 2024-10-30

methadone and Ataxia

methadone has been researched along with Ataxia in 5 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.

Research Excerpts

ExcerptRelevanceReference
"Here, we report a patient who developed acute bilateral hearing loss, ataxia and paraparesis subsequently to intravenous methadone-abuse."4.02Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments. ( Haessner, S; Johnen, A; Landmeyer, NC; Meyer Zu Hörste, G; Pawlitzki, M; Repple, J; Schulte-Mecklenbeck, A; Wiendl, H, 2021)
" In contrast, identical treatment did not alter the potency of the benzodiazepine alprazolam to induce ataxia."3.67Modification of the response to opioid and nonopioid drugs by chronic opioid antagonist treatment. ( Inturrisi, CE; Yoburn, BC, 1988)
"Development of any ataxia and/or sedation was recorded."2.71A comparison of the analgesic effects of caudal epidural methadone and lidocaine in the horse. ( Mosing, M; Olbrich, VH, 2003)
"The fragile X-associated tremor ataxia syndrome (FXTAS) is caused by the premutation in FMR1 gene."1.42Methadone use in a male with the FMRI premutation and FXTAS. ( Adams, PE; Faradz, SM; Hagerman, RJ; Lozano, R; Muzar, Z; Schneider, A; Tassone, F, 2015)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Repple, J1
Haessner, S1
Johnen, A1
Landmeyer, NC1
Schulte-Mecklenbeck, A1
Pawlitzki, M1
Wiendl, H1
Meyer Zu Hörste, G1
Muzar, Z1
Lozano, R1
Schneider, A1
Adams, PE1
Faradz, SM1
Tassone, F1
Hagerman, RJ1
Olbrich, VH1
Mosing, M1
Yong, RL1
Holmes, DT1
Sreenivasan, GM1
Yoburn, BC1
Inturrisi, CE1

Trials

1 trial available for methadone and Ataxia

ArticleYear
A comparison of the analgesic effects of caudal epidural methadone and lidocaine in the horse.
    Veterinary anaesthesia and analgesia, 2003, Volume: 30, Issue:3

    Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Animals; Ataxia; Cross-Over Studies; De

2003

Other Studies

4 other studies available for methadone and Ataxia

ArticleYear
Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments.
    BMC neurology, 2021, Feb-22, Volume: 21, Issue:1

    Topics: Administration, Intravenous; Analgesics, Opioid; Ataxia; Brain; Brain Diseases; Brain Edema; Cogniti

2021
Methadone use in a male with the FMRI premutation and FXTAS.
    American journal of medical genetics. Part A, 2015, Volume: 167, Issue:6

    Topics: Ataxia; Disease Progression; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Expressi

2015
Aluminum toxicity due to intravenous injection of boiled methadone.
    The New England journal of medicine, 2006, Mar-16, Volume: 354, Issue:11

    Topics: Adult; Aluminum; Ataxia; Chelation Therapy; Deferoxamine; Dysarthria; Humans; Male; Methadone; Poiso

2006
Modification of the response to opioid and nonopioid drugs by chronic opioid antagonist treatment.
    Life sciences, 1988, Volume: 42, Issue:18

    Topics: Alprazolam; Analgesia; Animals; Ataxia; Cocaine; Drug Implants; Kinetics; Male; Methadone; Mice; Mor

1988