methadone has been researched along with Astrocytosis in 3 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methadone is a centrally-acting synthetic opioid analgesic widely used in the methadone maintenance therapy (MMT) programs throughout the world." | 1.91 | Chronic exposure to methadone induces activated microglia and astrocyte and cell death in the cerebellum of adult male rats. ( Aliaghaei, A; Hassanian-Moghaddam, H; Osgoei, LT; Zamani, N, 2023) |
| "Methadone is a centrally-acting synthetic opioid analgesic widely used in methadone maintenance therapy (MMT) programs throughout the world." | 1.72 | Chronic exposure to methadone impairs memory, induces microgliosis, astrogliosis and neuroinflammation in the hippocampus of adult male rats. ( Abdollahifar, MA; Aliaghaei, A; Boroujeni, ME; Fathabadi, FF; Fathi, M; Moghaddam, MH; Navaei, F; Norouzian, M; Vakili, K; Zamani, N, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Navaei, F | 1 |
| Fathabadi, FF | 1 |
| Moghaddam, MH | 1 |
| Fathi, M | 1 |
| Vakili, K | 1 |
| Abdollahifar, MA | 1 |
| Boroujeni, ME | 1 |
| Zamani, N | 4 |
| Norouzian, M | 1 |
| Aliaghaei, A | 2 |
| Osgoei, LT | 1 |
| Hassanian-Moghaddam, H | 1 |
| Hutchinson, MR | 1 |
| Lewis, SS | 1 |
| Coats, BD | 1 |
| Rezvani, N | 1 |
| Zhang, Y | 1 |
| Wieseler, JL | 1 |
| Somogyi, AA | 1 |
| Yin, H | 1 |
| Maier, SF | 1 |
| Rice, KC | 1 |
| Watkins, LR | 1 |
3 other studies available for methadone and Astrocytosis
| Article | Year |
|---|---|
Chronic exposure to methadone impairs memory, induces microgliosis, astrogliosis and neuroinflammation in the hippocampus of adult male rats.
Topics: Analgesics, Opioid; Animals; Gliosis; Hippocampus; Male; Methadone; Microglia; Neuroinflammatory Dis | 2022 |
Chronic exposure to methadone induces activated microglia and astrocyte and cell death in the cerebellum of adult male rats.
Topics: Analgesics, Opioid; Animals; Apoptosis; Astrocytes; Cerebellum; Gliosis; Male; Methadone; Microglia; | 2023 |
Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences.
Topics: Analgesics, Opioid; Animals; Gliosis; Hyperalgesia; Immunity, Innate; Inflammation; Inflammation Med | 2010 |