methadone has been researched along with Astrocytoma, Grade IV in 10 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methadone, which is used as maintenance medication for outpatient treatment of opioid dependence or as an analgesic drug, has been suggested by preclinical in vitro and mouse studies to induce cell death and sensitivity to chemo- or radiotherapy in leukemia, glioblastoma, and carcinoma cells." | 9.05 | Against Repurposing Methadone for Glioblastoma Therapy. ( Eckert, F; Ganser, K; Huber, SM; Klumpp, L; Stransky, N; Vatter, T; Zips, D, 2020) |
| "D,L-methadone (MET), an analgesic drug used for pain treatment and opiate addiction, has achieved attention from oncologists and social media as possible chemoensitizing agent in cancer therapy, notably brain cancer (glioblastoma multiforme, GBM)." | 8.02 | Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent. ( Ciftcioglu, J; Eckstein, N; Haas, B; Jermar, S; Kaina, B; Weickhardt, S, 2021) |
| "When only treated with D,L-methadone, 1 µM of the opioid was sufficient to reduce viability of fibroblasts, whereas 10 µM was needed to significantly reduce glioblastoma cell viability." | 7.91 | D,L-Methadone does not improve radio- and chemotherapy in glioblastoma in vitro. ( Baran-Schmidt, R; Dietterle, J; Gaunitz, F; Glasow, A; Matusova, M; Meixensberger, J; Neumann, K; Oppermann, H, 2019) |
| "Although having shown promising clinical outcomes, the effectiveness of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) for squamous cell carcinoma (SCC) and glioblastoma remains to be improved." | 7.91 | Methadone enhances the effectiveness of 5-aminolevulinic acid-based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro. ( Buchner, A; Gederaas, OA; Pohla, H; Pongratz, T; Rühm, A; Shi, L; Sroka, R; Stepp, H; Wang, X; Zhang, L; Zimmermann, W, 2019) |
| "Recently, D,L-methadone has been put forward as adjuvant treatment in glioblastoma (GBM)." | 7.88 | Efficacy of D,L-methadone in the treatment of glioblastoma in vitro. ( Brawanski, A; Brawanski, K; Brockhoff, G; Freyschlag, C; Hau, P; Lohmeier, A; Proescholdt, MA; Riemenschneider, MJ; Thomé, C; Vollmann-Zwerenz, A, 2018) |
| "D,L-methadone can be safely combined with standard glioma chemotherapy without increasing the risk of toxicity or vegetative symptoms such as tachycardia, sweating and restlessness." | 7.85 | Safety and Tolerance of D,L-Methadone in Combination with Chemotherapy in Patients with Glioma. ( Friesen, C; Misch, M; Onken, J; Vajkoczy, P, 2017) |
| "Methadone is an analgesic drug used for pain treatment and heroin substitution." | 5.56 | Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells. ( Beltzig, L; Haas, B; Kaina, B; Piee-Staffa, A, 2020) |
| "Methadone, which is used as maintenance medication for outpatient treatment of opioid dependence or as an analgesic drug, has been suggested by preclinical in vitro and mouse studies to induce cell death and sensitivity to chemo- or radiotherapy in leukemia, glioblastoma, and carcinoma cells." | 5.05 | Against Repurposing Methadone for Glioblastoma Therapy. ( Eckert, F; Ganser, K; Huber, SM; Klumpp, L; Stransky, N; Vatter, T; Zips, D, 2020) |
| "D,L-methadone (MET), an analgesic drug used for pain treatment and opiate addiction, has achieved attention from oncologists and social media as possible chemoensitizing agent in cancer therapy, notably brain cancer (glioblastoma multiforme, GBM)." | 4.02 | Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent. ( Ciftcioglu, J; Eckstein, N; Haas, B; Jermar, S; Kaina, B; Weickhardt, S, 2021) |
| " Thus, in the current study, we aimed to investigate the effects of metformin on the development of morphine and/or methadone-induced tolerance in human glioblastoma (T98G) cell line." | 3.91 | In vitro evaluation of effects of metformin on morphine and methadone tolerance through mammalian target of rapamycin signaling pathway. ( Dehpour, AR; Esmaeili, J; Sahebgharani, M; Shirooie, S, 2019) |
| "When only treated with D,L-methadone, 1 µM of the opioid was sufficient to reduce viability of fibroblasts, whereas 10 µM was needed to significantly reduce glioblastoma cell viability." | 3.91 | D,L-Methadone does not improve radio- and chemotherapy in glioblastoma in vitro. ( Baran-Schmidt, R; Dietterle, J; Gaunitz, F; Glasow, A; Matusova, M; Meixensberger, J; Neumann, K; Oppermann, H, 2019) |
| "Although having shown promising clinical outcomes, the effectiveness of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) for squamous cell carcinoma (SCC) and glioblastoma remains to be improved." | 3.91 | Methadone enhances the effectiveness of 5-aminolevulinic acid-based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro. ( Buchner, A; Gederaas, OA; Pohla, H; Pongratz, T; Rühm, A; Shi, L; Sroka, R; Stepp, H; Wang, X; Zhang, L; Zimmermann, W, 2019) |
| "Recently, D,L-methadone has been put forward as adjuvant treatment in glioblastoma (GBM)." | 3.88 | Efficacy of D,L-methadone in the treatment of glioblastoma in vitro. ( Brawanski, A; Brawanski, K; Brockhoff, G; Freyschlag, C; Hau, P; Lohmeier, A; Proescholdt, MA; Riemenschneider, MJ; Thomé, C; Vollmann-Zwerenz, A, 2018) |
| "D,L-methadone can be safely combined with standard glioma chemotherapy without increasing the risk of toxicity or vegetative symptoms such as tachycardia, sweating and restlessness." | 3.85 | Safety and Tolerance of D,L-Methadone in Combination with Chemotherapy in Patients with Glioma. ( Friesen, C; Misch, M; Onken, J; Vajkoczy, P, 2017) |
| "Methadone is an analgesic drug used for pain treatment and heroin substitution." | 1.56 | Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells. ( Beltzig, L; Haas, B; Kaina, B; Piee-Staffa, A, 2020) |
| "Glioblastoma are the most frequent and malignant human brain tumors, having a very poor prognosis." | 1.40 | Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma. ( Alt, A; Debatin, KM; Fichtner, I; Friesen, C; Hilger, R; Hormann, I; Miltner, E; Roscher, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 4 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vatter, T | 1 |
| Klumpp, L | 1 |
| Ganser, K | 1 |
| Stransky, N | 1 |
| Zips, D | 1 |
| Eckert, F | 1 |
| Huber, SM | 1 |
| Kaina, B | 2 |
| Beltzig, L | 1 |
| Piee-Staffa, A | 1 |
| Haas, B | 2 |
| Ciftcioglu, J | 1 |
| Jermar, S | 1 |
| Weickhardt, S | 1 |
| Eckstein, N | 1 |
| Smit, AM | 1 |
| Kilian, S | 1 |
| Emsley, RA | 1 |
| Luckhoff, HK | 1 |
| Swartz, L | 1 |
| Seedat, S | 1 |
| Asmal, L | 1 |
| Kloppers, JF | 1 |
| de Kock, A | 1 |
| Cronjé, J | 1 |
| van Marle, AC | 1 |
| Aouad, MR | 1 |
| Khan, DJO | 1 |
| Said, MA | 1 |
| Al-Kaff, NS | 1 |
| Rezki, N | 1 |
| Ali, AA | 1 |
| Bouqellah, N | 1 |
| Hagar, M | 1 |
| Sanga, G | 1 |
| Jao, I | 1 |
| Mumba, N | 1 |
| Mwalukore, S | 1 |
| Kamuya, D | 1 |
| Davies, A | 1 |
| McGready, R | 1 |
| Rijken, MJ | 1 |
| Turner, C | 1 |
| Than, HH | 1 |
| Tun, NW | 1 |
| Min, AM | 1 |
| Hla, S | 1 |
| Wai, NS | 1 |
| Proux, K | 1 |
| Min, TH | 1 |
| Gilder, ME | 1 |
| Sneddon, A | 1 |
| Sorbera, M | 1 |
| Fischetti, B | 1 |
| Khaimova, R | 1 |
| Niewinski, M | 1 |
| Wen, K | 1 |
| Tarke, A | 1 |
| Sidney, J | 1 |
| Methot, N | 1 |
| Yu, ED | 1 |
| Zhang, Y | 1 |
| Dan, JM | 1 |
| Goodwin, B | 1 |
| Rubiro, P | 1 |
| Sutherland, A | 1 |
| Wang, E | 1 |
| Frazier, A | 1 |
| Ramirez, SI | 1 |
| Rawlings, SA | 1 |
| Smith, DM | 1 |
| da Silva Antunes, R | 1 |
| Peters, B | 1 |
| Scheuermann, RH | 1 |
| Weiskopf, D | 1 |
| Crotty, S | 1 |
| Grifoni, A | 1 |
| Sette, A | 1 |
| Yan, P | 1 |
| Liang, DY | 1 |
| Xu, WH | 1 |
| Xue, L | 1 |
| Yu, MF | 1 |
| Shen, JH | 1 |
| Liu, QH | 1 |
| Peng, YB | 1 |
| Arenas, M | 1 |
| Algara, M | 1 |
| De Febrer, G | 1 |
| Rubio, C | 1 |
| Sanz, X | 1 |
| de la Casa, MA | 1 |
| Vasco, C | 1 |
| Marín, J | 1 |
| Fernández-Letón, P | 1 |
| Villar, J | 1 |
| Torres-Royo, L | 1 |
| Villares, P | 1 |
| Membrive, I | 1 |
| Acosta, J | 1 |
| López-Cano, M | 1 |
| Araguas, P | 1 |
| Quera, J | 1 |
| Rodríguez-Tomás, F | 1 |
| Montero, A | 1 |
| Buchler, A | 1 |
| Munch, M | 1 |
| Farber, G | 1 |
| Zhao, X | 1 |
| Al-Haddad, R | 1 |
| Farber, E | 1 |
| Rotstein, BH | 1 |
| Hou, J | 1 |
| Long, T | 1 |
| Yang, N | 1 |
| Chen, D | 1 |
| Zeng, S | 1 |
| Zheng, K | 1 |
| Liao, G | 1 |
| Hu, S | 1 |
| De Gregori, S | 1 |
| De Silvestri, A | 1 |
| Molinaro, MD | 1 |
| Monzillo, V | 1 |
| Biscarini, S | 1 |
| Colaneri, M | 1 |
| Gallazzi, I | 1 |
| Bartoli, A | 1 |
| Bruno, R | 1 |
| Seminari, E | 1 |
| Dang, W | 1 |
| Xiao, J | 1 |
| Ma, Q | 1 |
| Miao, J | 1 |
| Cao, M | 1 |
| Chen, L | 1 |
| Shi, Y | 1 |
| Yao, X | 1 |
| Yu, S | 1 |
| Liu, X | 1 |
| Cui, Y | 1 |
| Zhang, X | 1 |
| Bian, X | 1 |
| Norlin, JM | 1 |
| Kellerborg, K | 1 |
| Odin, P | 1 |
| Onken, J | 1 |
| Friesen, C | 2 |
| Vajkoczy, P | 1 |
| Misch, M | 1 |
| Brawanski, K | 1 |
| Brockhoff, G | 1 |
| Hau, P | 1 |
| Vollmann-Zwerenz, A | 1 |
| Freyschlag, C | 1 |
| Lohmeier, A | 1 |
| Riemenschneider, MJ | 1 |
| Thomé, C | 1 |
| Brawanski, A | 1 |
| Proescholdt, MA | 1 |
| Shirooie, S | 1 |
| Sahebgharani, M | 1 |
| Esmaeili, J | 1 |
| Dehpour, AR | 1 |
| Oppermann, H | 1 |
| Matusova, M | 1 |
| Glasow, A | 1 |
| Dietterle, J | 1 |
| Baran-Schmidt, R | 1 |
| Neumann, K | 1 |
| Meixensberger, J | 1 |
| Gaunitz, F | 1 |
| Shi, L | 1 |
| Buchner, A | 1 |
| Pohla, H | 1 |
| Pongratz, T | 1 |
| Rühm, A | 1 |
| Zimmermann, W | 1 |
| Gederaas, OA | 1 |
| Zhang, L | 1 |
| Wang, X | 1 |
| Stepp, H | 1 |
| Sroka, R | 1 |
| Hormann, I | 1 |
| Roscher, M | 1 |
| Fichtner, I | 1 |
| Alt, A | 1 |
| Hilger, R | 1 |
| Debatin, KM | 1 |
| Miltner, E | 1 |
1 review available for methadone and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Against Repurposing Methadone for Glioblastoma Therapy.
Topics: Antineoplastic Agents; Brain Neoplasms; Drug Repositioning; Glioblastoma; Humans; Methadone; Recepto | 2020 |
1 trial available for methadone and Astrocytoma, Grade IV
8 other studies available for methadone and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cellular Senescence; Cytotoxins; D | 2020 |
Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent.
Topics: Analgesics, Opioid; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumo | 2021 |
Safety and Tolerance of D,L-Methadone in Combination with Chemotherapy in Patients with Glioma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Brain Neoplasms; Clinical Trials as To | 2017 |
Efficacy of D,L-methadone in the treatment of glioblastoma in vitro.
Topics: Adult; Analgesics, Opioid; Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, | 2018 |
In vitro evaluation of effects of metformin on morphine and methadone tolerance through mammalian target of rapamycin signaling pathway.
Topics: AMP-Activated Protein Kinase Kinases; Analgesics, Opioid; Animals; Cell Line, Tumor; Cyclic AMP; Dru | 2019 |
D,L-Methadone does not improve radio- and chemotherapy in glioblastoma in vitro.
Topics: Adult; Aged; Analgesics, Opioid; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Ce | 2019 |
Methadone enhances the effectiveness of 5-aminolevulinic acid-based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro.
Topics: Aminolevulinic Acid; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Drug Synergi | 2019 |
Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cy | 2014 |