methadone has been researched along with Arrhythmia in 52 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The number of deaths associated with methadone use increased dramatically in parallel with marked increases in its use, particularly for treatment of chronic pain." | 8.90 | Methadone overdose and cardiac arrhythmia potential: findings from a review of the evidence for an American Pain Society and College on Problems of Drug Dependence clinical practice guideline. ( Chou, R; Dana, T; Weimer, MB, 2014) |
| "Methadone is increasingly prescribed for chronic pain, yet the associated mortality appears to be rising disproportionately relative to other opioid analgesics." | 8.85 | Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation. ( Andrews, CM; Capacchione, JF; Haigney, MC; Krantz, MJ; Marcuson, MJ; Wedam, EF, 2009) |
| "In spite of challenges related to the variable pharmacokinetics and concerns regarding increase in QTc time, current evidence indicates that opioid switching to methadone improves pain control in a substantial proportion of patients who are candidates for opioid switching." | 8.84 | Clinical pharmacology of methadone for pain. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Moksnes, K, 2008) |
| "Methadone has been associated with QTc prolongation and ventricular arrhythmias but the prevalence of QTc prolongation and association with ventricular arrhythmias remains unclear." | 7.81 | Methadone Therapy in Underserved Urban Community: QTc Prolongation and Life-Threatening Ventricular Arrhythmias. ( Cheng, A; Chowdhury, M; Khilkin, M; Palma, E; Wong, J, 2015) |
| "To assess the relative frequency of reporting of adverse events involving ventricular arrhythmia, cardiac arrest, corrected QT interval (QTc) prolongation or torsade de pointes to the US Food and Drug Administration (FDA) between buprenorphine and methadone." | 7.81 | Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration. ( Haigney, MC; Kao, DP; Krantz, MJ; Mehler, PS, 2015) |
| "To estimate risk of death due to cardiac arrhythmia during methadone maintenance treatment." | 7.77 | Estimating the risk of fatal arrhythmia in patients in methadone maintenance treatment for heroin addiction. ( Batey, R; Bell, J; Butler, B; Lawrance, A; Rubin, G, 2011) |
| "In November, 2006, the United States Food and Drug Administration issued a Health Alert for health professionals on risks of death, cardiac arrhythmias, and narcotic overdose associated with methadone." | 7.74 | Death, narcotic overdose, and serious cardiac arrhythmias: information for healthcare professionals on methadone. ( , 2007) |
| " Use of the developed PBK model to convert concentration-response curves for the effect of methadone on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) in the so-called multi electrode array (MEA) assay resulted in predictions for in vivo dose-response curves for methadone-induced cardiotoxicity that matched the available in vivo data." | 5.56 | Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone. ( Bouwmeester, H; Rietjens, IMCM; Shi, M; Strikwold, M, 2020) |
| " Methadone has a higher capability to induce long QT interval and dangerous arrhythmias in conventional doses than others." | 4.98 | Opioids and Cardiac Arrhythmia: A Literature Review. ( Behzadi, M; Beik, A; Joukar, S, 2018) |
| "The number of deaths associated with methadone use increased dramatically in parallel with marked increases in its use, particularly for treatment of chronic pain." | 4.90 | Methadone overdose and cardiac arrhythmia potential: findings from a review of the evidence for an American Pain Society and College on Problems of Drug Dependence clinical practice guideline. ( Chou, R; Dana, T; Weimer, MB, 2014) |
| "Methadone is increasingly prescribed for chronic pain, yet the associated mortality appears to be rising disproportionately relative to other opioid analgesics." | 4.85 | Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation. ( Andrews, CM; Capacchione, JF; Haigney, MC; Krantz, MJ; Marcuson, MJ; Wedam, EF, 2009) |
| "In spite of challenges related to the variable pharmacokinetics and concerns regarding increase in QTc time, current evidence indicates that opioid switching to methadone improves pain control in a substantial proportion of patients who are candidates for opioid switching." | 4.84 | Clinical pharmacology of methadone for pain. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Moksnes, K, 2008) |
| "The nonprescription drugs loperamide and mitragynine are associated with disproportionate reports of life-threatening ventricular arrhythmia in North America." | 4.31 | Ventricular Arrhythmias Associated With Over-the-Counter and Recreational Opioids. ( Haigney, MCP; Kao, DP; Kleiman, RB; Klein, M; Krantz, MJ; Rudo, TJ; Stockbridge, N, 2023) |
| "Electrocardiogram changes due to acute opioid toxicity in children are not common, although in the case of methadone poisoning, long QT interval and associated arrhythmias should be anticipated." | 4.02 | Electrocardiographic Changes in Children With Acute Opioid Poisoning: A Cross-Sectional Study. ( Arzanin, F; Chahkandi, T; Kafian Atary, S; Rabiee, N; Riasi, H; Salehi, F, 2021) |
| "Methadone, a widely prescribed medication for chronic pain and opioid addiction, is associated with respiratory depression and increased predisposition for torsades de pointes, a potentially fatal arrhythmia." | 4.02 | Methadone Destabilizes Cardiac Repolarization During Sleep. ( Buckenmaier, C; Crainiceanu, C; Gaynanova, I; Haigney, MC; Ivanescu, AE; Punjabi, NM; Solhjoo, S; Wicken, C, 2021) |
| "Methadone has been associated with QTc prolongation and ventricular arrhythmias but the prevalence of QTc prolongation and association with ventricular arrhythmias remains unclear." | 3.81 | Methadone Therapy in Underserved Urban Community: QTc Prolongation and Life-Threatening Ventricular Arrhythmias. ( Cheng, A; Chowdhury, M; Khilkin, M; Palma, E; Wong, J, 2015) |
| "To assess the relative frequency of reporting of adverse events involving ventricular arrhythmia, cardiac arrest, corrected QT interval (QTc) prolongation or torsade de pointes to the US Food and Drug Administration (FDA) between buprenorphine and methadone." | 3.81 | Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration. ( Haigney, MC; Kao, DP; Krantz, MJ; Mehler, PS, 2015) |
| "Several studies have reported prolonged QTc intervals in patients under methadone maintenance treatment, including development of torsade-de-pointes arrhythmia and death." | 3.79 | QTc prolongation in methadone maintenance--the role of HCV infection. ( Boesch, L; Bruggmann, P; Falcato, L; Gholami, N; Stohler, R, 2013) |
| "To estimate risk of death due to cardiac arrhythmia during methadone maintenance treatment." | 3.77 | Estimating the risk of fatal arrhythmia in patients in methadone maintenance treatment for heroin addiction. ( Batey, R; Bell, J; Butler, B; Lawrance, A; Rubin, G, 2011) |
| "Physicians should be aware of the potential interaction between voriconazole, esomeprazole and methadone leading to arrhythmia." | 3.77 | Ventricular bigeminy associated with voriconazole, methadone and esomeprazole. ( Herbrecht, R; Kemmel, V; Levêque, D; Nivoix, Y; Scholler, J, 2011) |
| "In November, 2006, the United States Food and Drug Administration issued a Health Alert for health professionals on risks of death, cardiac arrhythmias, and narcotic overdose associated with methadone." | 3.74 | Death, narcotic overdose, and serious cardiac arrhythmias: information for healthcare professionals on methadone. ( , 2007) |
| "Immediate attention must be given to the respiratory system of the heroin abuser; then he should be given naloxone HCl." | 3.65 | Treating heroin overdose. ( Calabro, JJ; Neaderthal, RL, 1975) |
| "To reduce the risk of cardiac arrhythmias and to improve patient outcomes, consideration of accurate patient selection, concomitant medications, electrolyte monitoring, and vigilant ECG monitoring should be considered." | 2.82 | Effects of opioid receptor agonist and antagonist medications on electrocardiogram changes and presentation of cardiac arrhythmia: review article. ( Catanzaro, JN; Delisle, BP; Di Biase, L; Elayi, CS; Etaee, F; Komaki, A; Natale, A; Tobin, M; Vuppala, S, 2022) |
| " We systematically searched for studies of acute toxicity of quetiapine or other antipsychotics combined with morphine or methadone." | 2.72 | Quetiapine and other antipsychotics combined with opioids in legal autopsy cases: A random finding or cause of fatal outcome? ( Andersen, CU; Andersen, FD; Simonsen, U, 2021) |
| "Mainstreaming opioid addiction treatment has many advantages; its success will depend on resolution of ethical and delivery system issues as well as improved and expanded training of physicians in addiction medicine." | 2.42 | Treating opioid dependence. Growing implications for primary care. ( Krantz, MJ; Mehler, PS, 2004) |
| "A review of the literature of multiple drug abuse involving two or more drug categories where at least one is a nonopiate, nonalcoholic substance (MDA NONA) suggested the possibility that sedative-hypnotics were the culpable agent for neuropsychological deficits in this group." | 2.36 | Multiple drug abuse involving nonopiate, nonalcoholic substances. II. Physical damage, long-term psychological effects and treatment approaches and success. ( Kornblith, AB, 1981) |
| "Only 14." | 1.72 | Association of Medication-Assisted Therapy with New Onset of Cardiac Arrhythmia in Patients Diagnosed with Opioid Use Disorders. ( Digbeu, B; Kuo, YF; Priyadarshni, S; Raji, MA; Yu, X, 2022) |
| " Use of the developed PBK model to convert concentration-response curves for the effect of methadone on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) in the so-called multi electrode array (MEA) assay resulted in predictions for in vivo dose-response curves for methadone-induced cardiotoxicity that matched the available in vivo data." | 1.56 | Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone. ( Bouwmeester, H; Rietjens, IMCM; Shi, M; Strikwold, M, 2020) |
| "A clinically significant arrhythmia occurred in one dog at 1 mg kg(-1) that required reversal with butorphanol." | 1.40 | Electrocardiographic evaluation and degree of sedation with three doses of methadone in healthy dogs [corrected]. ( Abimussi, CJ; de Souza Oliva, VN; dos Santos, PP; Menegheti, TM; Pacheco, AD; Pacheco, CM; Perez, B; Wagatsuma, JT, 2014) |
| " Clinically significant MDIs included withdrawal symptoms, which were found among MMTP patients co-administered with buprenorphine or tramadol; severe QTc prolongation effect, which might be associated with use of haloperidol or droperidol; and additive CNS and respiratory depression, which could result from use of methadone in combination with chlorpromazine or thioridazine." | 1.38 | Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan. ( Lee, HY; Li, JH; Tang, HP; Wu, JS; Wu, LT; Yen, CF, 2012) |
| "Methadone is a synthetic opioid, an analgesic and an antiaddictive." | 1.35 | The effects of chiral isolates of methadone on the cardiac potassium channel IKr. ( Lin, C; Molnar, J; Somberg, J; Somberg, T, 2009) |
| "Methadone was subsequently shown to prolong the QT interval as well." | 1.34 | Physician awareness of the cardiac effects of methadone: results of a national survey. ( Bucher Bartelson, B; Krantz, MJ; Rowan, SB; Schmittner, J, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (13.46) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 16 (30.77) | 29.6817 |
| 2010's | 20 (38.46) | 24.3611 |
| 2020's | 9 (17.31) | 2.80 |
| Authors | Studies |
|---|---|
| Etaee, F | 1 |
| Tobin, M | 1 |
| Vuppala, S | 1 |
| Komaki, A | 1 |
| Delisle, BP | 1 |
| Di Biase, L | 1 |
| Catanzaro, JN | 1 |
| Natale, A | 1 |
| Elayi, CS | 1 |
| Raji, MA | 1 |
| Priyadarshni, S | 1 |
| Yu, X | 1 |
| Digbeu, B | 1 |
| Kuo, YF | 1 |
| Ryan, K | 1 |
| Benz, P | 1 |
| Zosel, A | 1 |
| Farkas, A | 1 |
| Theobald, J | 1 |
| Krantz, MJ | 8 |
| Rudo, TJ | 1 |
| Haigney, MCP | 1 |
| Stockbridge, N | 1 |
| Kleiman, RB | 1 |
| Klein, M | 1 |
| Kao, DP | 2 |
| Riasi, H | 1 |
| Rabiee, N | 1 |
| Chahkandi, T | 1 |
| Arzanin, F | 1 |
| Kafian Atary, S | 1 |
| Salehi, F | 1 |
| Shi, M | 1 |
| Bouwmeester, H | 1 |
| Rietjens, IMCM | 1 |
| Strikwold, M | 1 |
| Schimmel, J | 1 |
| Manini, AF | 1 |
| Andersen, FD | 1 |
| Simonsen, U | 1 |
| Andersen, CU | 1 |
| Solhjoo, S | 1 |
| Punjabi, NM | 1 |
| Ivanescu, AE | 1 |
| Crainiceanu, C | 1 |
| Gaynanova, I | 1 |
| Wicken, C | 1 |
| Buckenmaier, C | 1 |
| Haigney, MC | 4 |
| Stock, EM | 1 |
| Zeber, JE | 1 |
| McNeal, CJ | 1 |
| Banchs, JE | 1 |
| Copeland, LA | 1 |
| Sheibani, M | 1 |
| Zamani, N | 1 |
| Hassanian-Moghaddam, H | 1 |
| Behzadi, M | 1 |
| Joukar, S | 1 |
| Beik, A | 1 |
| Katz, DF | 2 |
| Sun, J | 1 |
| Khatri, V | 1 |
| Kao, D | 2 |
| Bucher-Bartelson, B | 1 |
| Traut, C | 1 |
| Lundin-Martinez, J | 1 |
| Goodman, M | 1 |
| Mehler, PS | 4 |
| Tanner, JC | 1 |
| Lake-Bakaar, GA | 1 |
| Kittleson, MD | 1 |
| Gholami, N | 1 |
| Boesch, L | 1 |
| Falcato, L | 1 |
| Stohler, R | 1 |
| Bruggmann, P | 1 |
| Menegheti, TM | 1 |
| Wagatsuma, JT | 1 |
| Pacheco, AD | 1 |
| Perez, B | 1 |
| Pacheco, CM | 1 |
| Abimussi, CJ | 1 |
| dos Santos, PP | 1 |
| de Souza Oliva, VN | 1 |
| Albright, K | 1 |
| Chou, R | 1 |
| Weimer, MB | 1 |
| Dana, T | 1 |
| Chowdhury, M | 1 |
| Wong, J | 1 |
| Cheng, A | 1 |
| Khilkin, M | 1 |
| Palma, E | 1 |
| Carlquist, JF | 1 |
| Moody, DE | 1 |
| Knight, S | 1 |
| Johnson, EG | 1 |
| Fang, WB | 1 |
| Huntinghouse, JA | 1 |
| Rollo, JS | 1 |
| Webster, LR | 1 |
| Anderson, JL | 1 |
| Cataldo, M | 1 |
| Krantz, M | 1 |
| Fonseca, F | 1 |
| Marti-Almor, J | 1 |
| Pastor, A | 1 |
| Cladellas, M | 1 |
| Farré, M | 1 |
| de la Torre, R | 1 |
| Torrens, M | 1 |
| Lin, C | 1 |
| Somberg, T | 1 |
| Molnar, J | 1 |
| Somberg, J | 1 |
| Eisenberg, E | 1 |
| Andrews, CM | 1 |
| Wedam, EF | 1 |
| Marcuson, MJ | 1 |
| Capacchione, JF | 1 |
| Wallner, C | 1 |
| Stöllberger, C | 1 |
| Hlavin, A | 1 |
| Finsterer, J | 1 |
| Hager, I | 1 |
| Hermann, P | 1 |
| McCance-Katz, EF | 2 |
| Butler, B | 1 |
| Rubin, G | 1 |
| Lawrance, A | 1 |
| Batey, R | 1 |
| Bell, J | 1 |
| Karch, SB | 1 |
| Scholler, J | 1 |
| Nivoix, Y | 1 |
| Herbrecht, R | 1 |
| Kemmel, V | 1 |
| Levêque, D | 1 |
| Lee, HY | 1 |
| Li, JH | 1 |
| Wu, LT | 1 |
| Wu, JS | 1 |
| Yen, CF | 1 |
| Tang, HP | 1 |
| Stallvik, M | 1 |
| Nordstrand, B | 1 |
| Kristensen, Ø | 1 |
| Bathen, J | 1 |
| Skogvoll, E | 1 |
| Spigset, O | 1 |
| Walker, PW | 1 |
| Klein, D | 1 |
| Kasza, L | 1 |
| Reddy, S | 1 |
| Fisch, M | 1 |
| Bruera, E | 1 |
| Martell, BA | 1 |
| Arnsten, JH | 1 |
| Gourevitch, MN | 1 |
| Bernard, JP | 1 |
| Mørland, J | 1 |
| Khiabani, HZ | 1 |
| Rowan, SB | 1 |
| Schmittner, J | 1 |
| Bucher Bartelson, B | 1 |
| Fredheim, OM | 1 |
| Moksnes, K | 1 |
| Borchgrevink, PC | 1 |
| Kaasa, S | 1 |
| Dale, O | 1 |
| Moryl, N | 1 |
| Coyle, N | 1 |
| Foley, KM | 1 |
| Kornblith, AB | 1 |
| Shannon, DC | 1 |
| Kelly, DH | 1 |
| Hays, H | 1 |
| Gibson, TC | 1 |
| Neaderthal, RL | 1 |
| Calabro, JJ | 1 |
| Reidenberg, MM | 1 |
| Affrime, M | 1 |
| Stimmel, B | 1 |
| Lipski, J | 1 |
| Swartz, M | 1 |
| Donoso, E | 1 |
| Neal, MJ | 1 |
| Robson, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| ECG Device for Long QT Syndrome Screening in Newborns[NCT02412709] | Phase 2 | 4,000 participants (Anticipated) | Interventional | 2015-06-30 | Recruiting | ||
| Methadone Monitoring for Insights Into Adverse Events[NCT01191242] | 31 participants (Actual) | Observational | 2010-08-31 | Completed | |||
| Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit[NCT02025855] | Phase 4 | 46 participants (Anticipated) | Interventional | 2014-01-31 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01191242)
Timeframe: Day 1, Day 7, Day 21
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| Day 1 | Day 7 | Day 21 | |
| Methadone Maintenance Observation Group | 3.4 | 13.5 | 18.2 |
(NCT01191242)
Timeframe: Day 1, Day 7, Day 21
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| Day 1 | Day 7 | Day 21 | |
| Methadone Maintenance Observation Group | 1.2 | 6.6 | 10.5 |
(NCT01191242)
Timeframe: Day 1, Day 7, Day 21
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| Day 1 | Day 7 | Day 21 | |
| Methadone Maintenance Observation Group | 41.8 | 136.6 | 178.6 |
(NCT01191242)
Timeframe: Day 1, Day 7, Day 21
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| Day 1 | Day 7 | Day 21 | |
| Methadone Maintenance Observation Group | 23.0 | 78.4 | 105.0 |
(NCT01191242)
Timeframe: Day 1, Day 7, Day 21
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| Day 1 | Day 7 | Day 21 | |
| Methadone Maintenance Observation Group | 65.6 | 178.8 | 215.1 |
(NCT01191242)
Timeframe: Day 1, Day 7, Day 21
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| Day 1 | Day 7 | Day 21 | |
| Methadone Maintenance Observation Group | 32.2 | 84.2 | 106.1 |
(NCT01191242)
Timeframe: Day 1, Day 7, Day 21
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| Day 1 | Day 7 | Day 21 | |
| Methadone Maintenance Observation Group | 5.8 | 20.6 | 30.3 |
(NCT01191242)
Timeframe: Day 1, Day 7, Day 21
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| Day 1 | Day 7 | Day 21 | |
| Methadone Maintenance Observation Group | 3.8 | 9.1 | 13.7 |
(NCT01191242)
Timeframe: Day 1, Day 7, Day 21
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| Day 1 | Day 7 | Day 21 | |
| Methadone Maintenance Observation Group | 11.0 | 39.8 | 45.3 |
(NCT01191242)
Timeframe: Day 1, Day 7, Day 21
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| Day 1 | Day 7 | Day 21 | |
| Methadone Maintenance Observation Group | 4.8 | 17.7 | 26.6 |
(NCT01191242)
Timeframe: Day 1, Day 7, Day 21
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| Day 1 | Day 7 | Day 21 | |
| Methadone Maintenance Observation Group | 107.3 | 315.4 | 362.2 |
(NCT01191242)
Timeframe: Day 1, Day 7, Day 21
| Intervention | ng/mL (Mean) | ||
|---|---|---|---|
| Day 1 | Day 7 | Day 21 | |
| Methadone Maintenance Observation Group | 53.0 | 162.6 | 211.1 |
10 reviews available for methadone and Arrhythmia
| Article | Year |
|---|---|
Effects of opioid receptor agonist and antagonist medications on electrocardiogram changes and presentation of cardiac arrhythmia: review article.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Electrocardiography; Humans; Long QT Syndrome; Methadone; | 2022 |
Quetiapine and other antipsychotics combined with opioids in legal autopsy cases: A random finding or cause of fatal outcome?
Topics: Adolescent; Adult; Analgesics, Opioid; Animals; Antipsychotic Agents; Arrhythmias, Cardiac; Autopsy; | 2021 |
Opioids and Cardiac Arrhythmia: A Literature Review.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Electrocardiography; Humans; Methadone; Oxycodone; Tramado | 2018 |
Methadone overdose and cardiac arrhythmia potential: findings from a review of the evidence for an American Pain Society and College on Problems of Drug Dependence clinical practice guideline.
Topics: Arrhythmias, Cardiac; Chronic Pain; Drug Overdose; Humans; Methadone; Opioid-Related Disorders; Prac | 2014 |
Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Chronic Disease; Delayed Rectifier Potassium Channels; ERG | 2009 |
Treating opioid dependence. Growing implications for primary care.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Buprenorphine; Europe; Humans; Methadone; Methadyl Acetate | 2004 |
Clinical pharmacology of methadone for pain.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Chronic Disease; Clinical Trials as Topic; Drug Interactio | 2008 |
Multiple drug abuse involving nonopiate, nonalcoholic substances. II. Physical damage, long-term psychological effects and treatment approaches and success.
Topics: Amphetamines; Arrhythmias, Cardiac; Attention; Brain Damage, Chronic; Follow-Up Studies; Humans; Hyp | 1981 |
SIDS and near-sids (first of two parts).
Topics: ABO Blood-Group System; Adult; Arrhythmias, Cardiac; Autonomic Nervous System; Birth Order; Brain; C | 1982 |
The heart in myasthenia gravis.
Topics: Arrhythmias, Cardiac; Cholinesterase Inhibitors; Drug Synergism; Electrocardiography; Heart; Humans; | 1975 |
42 other studies available for methadone and Arrhythmia
| Article | Year |
|---|---|
Association of Medication-Assisted Therapy with New Onset of Cardiac Arrhythmia in Patients Diagnosed with Opioid Use Disorders.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Buprenorphine; Humans; Methadone; Naltrexone; Opiate Subst | 2022 |
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long | 2022 |
Ventricular Arrhythmias Associated With Over-the-Counter and Recreational Opioids.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Buprenorphine; Diphenoxylate; Humans; Loperamide; Methadon | 2023 |
Electrocardiographic Changes in Children With Acute Opioid Poisoning: A Cross-Sectional Study.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Child; Child, Preschool; Cross-Sectional Studies; Electroc | 2021 |
Integrating in vitro data and physiologically based kinetic modeling-facilitated reverse dosimetry to predict human cardiotoxicity of methadone.
Topics: Action Potentials; Analgesics, Opioid; Arrhythmias, Cardiac; Cardiotoxicity; Cell Line; Computer Sim | 2020 |
Opioid Use Disorder and COVID-19: Biological Plausibility for Worsened Outcomes.
Topics: Adaptive Immunity; Analgesics, Opioid; Arrhythmias, Cardiac; Betacoronavirus; Coronavirus Infections | 2020 |
Methadone Destabilizes Cardiac Repolarization During Sleep.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Arrhythmias, Cardiac; Electrocardiography; Femal | 2021 |
Psychotropic Pharmacotherapy Associated With QT Prolongation Among Veterans With Posttraumatic Stress Disorder.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Arrhythmias, Cardiac; Buspirone; Female; Humans; Male | 2018 |
Electrocardiographic Findings in Mortalities Due to Pure Methadone Toxicity.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Arrhythmias, Cardiac; Cardiotoxicity; Cause of Death; C | 2019 |
QTc interval screening in an opioid treatment program.
Topics: Adult; Analgesics, Opioid; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Male; Mass Scr | 2013 |
ECG of the Month. Arrhythmia.
Topics: Animals; Arrhythmias, Cardiac; Atropine; Dog Diseases; Dogs; Electrocardiography; Ethylene Glycol; F | 2013 |
QTc prolongation in methadone maintenance--the role of HCV infection.
Topics: Adult; Analgesics, Opioid; Arrhythmias, Cardiac; Cross-Sectional Studies; Dose-Response Relationship | 2013 |
Electrocardiographic evaluation and degree of sedation with three doses of methadone in healthy dogs [corrected].
Topics: Analgesics, Opioid; Animals; Arrhythmias, Cardiac; Conscious Sedation; Dogs; Dose-Response Relations | 2014 |
An ECG-based cardiac safety initiative is well received by opioid treatment program staff: results from a qualitative assessment.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Attitude of Health Personnel; Electrocardiography; Humans; | 2013 |
Methadone Therapy in Underserved Urban Community: QTc Prolongation and Life-Threatening Ventricular Arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Interactions; Electrocardi | 2015 |
A Possible Mechanistic Link Between the CYP2C19 Genotype, the Methadone Metabolite Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidene (EDDP), and Methadone-Induced Corrected QT Interval Prolongation in a Pilot Study.
Topics: Adult; Alleles; Arrhythmias, Cardiac; Cytochrome P-450 CYP2C19; Electrocardiography; Female; Gene Fr | 2015 |
Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration.
Topics: Adult; Arrhythmias, Cardiac; Buprenorphine; Female; Heart Arrest; Humans; Long QT Syndrome; Male; Me | 2015 |
Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Buprenorphine; Dose-Response Relationship, Drug; Humans; L | 2016 |
Reply to Cataldo (2016): Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration.
Topics: Arrhythmias, Cardiac; Buprenorphine; Electrocardiography; Humans; Long QT Syndrome; Methadone; Torsa | 2016 |
Prevalence of long QTc interval in methadone maintenance patients.
Topics: Adolescent; Adult; Arrhythmias, Cardiac; Electrocardiography; Female; Heart Rate; Humans; Logistic M | 2009 |
The effects of chiral isolates of methadone on the cardiac potassium channel IKr.
Topics: Analgesics, Opioid; Animals; Arrhythmias, Cardiac; ERG1 Potassium Channel; Ether-A-Go-Go Potassium C | 2009 |
European pain management discussion forum.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Europe; Herpes Zoster; Humans; Methadone; Morphine; Neural | 2008 |
Electrocardiographic abnormalities in opiate addicts.
Topics: Adolescent; Adult; Arrhythmias, Cardiac; Cross-Sectional Studies; Electrocardiography; Female; Human | 2008 |
[Commentary] Opioids and cardiogram abnormalities: providing treatment based on understanding the risks and benefits.
Topics: Arrhythmias, Cardiac; Electrocardiography; Humans; Methadone; Narcotics; Opioid-Related Disorders | 2008 |
Estimating the risk of fatal arrhythmia in patients in methadone maintenance treatment for heroin addiction.
Topics: Adult; Arrhythmias, Cardiac; Cohort Studies; Databases, Factual; Heroin Dependence; Humans; Methadon | 2011 |
(R)-methadone versus racemic methadone: what is best for patient care?
Topics: Arrhythmias, Cardiac; Humans; Methadone; Narcotics; Opioid-Related Disorders | 2011 |
Is it time to reformulate racemic methadone?
Topics: Adult; Arrhythmias, Cardiac; Chemistry, Pharmaceutical; Chronic Disease; Death, Sudden, Cardiac; Fem | 2011 |
Ventricular bigeminy associated with voriconazole, methadone and esomeprazole.
Topics: Adult; Analgesics, Opioid; Antifungal Agents; Arrhythmias, Cardiac; Drug Interactions; Esomeprazole; | 2011 |
Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Arrhythmias, Cardiac; Drug Interactions; Female; | 2012 |
Corrected QT interval during treatment with methadone and buprenorphine--relation to doses and serum concentrations.
Topics: Adult; Arrhythmias, Cardiac; Buprenorphine; Electrocardiography; Female; Humans; International Class | 2013 |
High dose methadone and ventricular arrhythmias: a report of three cases.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Arrhythmias, Cardiac; Drug Interactions; Heart Vent | 2003 |
Oral methadone for cancer pain: no indication of Q-T interval prolongation or torsades de pointes.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Electrocardiography; Heart Rate; Humans; Methadone; Neopla | 2004 |
Impact of methadone treatment on cardiac repolarization and conduction in opioid users.
Topics: Administration, Oral; Adult; Arrhythmias, Cardiac; Electrocardiography; Female; Humans; Male; Methad | 2005 |
[Methadone treatment and heart arrhythmia].
Topics: Arrhythmias, Cardiac; Cause of Death; Humans; Methadone; Narcotics; Risk Factors | 2007 |
Death, narcotic overdose, and serious cardiac arrhythmias: information for healthcare professionals on methadone.
Topics: Arrhythmias, Cardiac; Drug Overdose; Humans; Methadone; Patient Education as Topic; United States; U | 2007 |
Physician awareness of the cardiac effects of methadone: results of a national survey.
Topics: Arrhythmias, Cardiac; Awareness; Heroin Dependence; Humans; Long QT Syndrome; Methadone; Narcotics; | 2007 |
Managing an acute pain crisis in a patient with advanced cancer: "this is as much of a crisis as a code".
Topics: Acute Disease; Adenocarcinoma, Mucinous; Adjuvants, Anesthesia; Adult; Analgesics, Opioid; Anestheti | 2008 |
High dosing methadone and a possible relationship to serious cardia arrhythmias.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Humans; Methadone | 2001 |
Treating heroin overdose.
Topics: Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Emer | 1975 |
Influence of disease on binding of drugs to plasma proteins.
Topics: Arrhythmias, Cardiac; Arteriosclerosis; Blood Proteins; Blood Urea Nitrogen; Carbon Radioisotopes; C | 1973 |
Electrocardiographic changes in heroins, methadone and multiple drug abuse: a postulated mechanism of sudden death in narcotic addicts.
Topics: Adult; Alcoholism; Arrhythmias, Cardiac; Death, Sudden; Electrocardiography; Female; Heart; Heroin D | 1973 |
The analgesic and anaesthetic actions of tetrafluorobenzene.
Topics: Analgesics; Anesthesia, Inhalation; Anesthetics; Animals; Arrhythmias, Cardiac; Benzene; Blood Press | 1966 |