Page last updated: 2024-10-30

methadone and Apnea, Sleep

methadone has been researched along with Apnea, Sleep in 10 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Research Excerpts

ExcerptRelevanceReference
"Opioids increase the risk for sleep disordered breathing (SDB), but there are few studies examining the prevalence and risk factors for SDB, specifically central sleep apnea (CSA), and obstructive sleep apnea (OSA) in chronic pain patients on opioids as well as methadone maintained patients (MMPs)."8.93A narrative review: The effects of opioids on sleep disordered breathing in chronic pain patients and methadone maintained patients. ( Hassamal, S; Miotto, K; Saxon, AJ; Wang, T, 2016)
"Opioids increase the risk for sleep disordered breathing (SDB), but there are few studies examining the prevalence and risk factors for SDB, specifically central sleep apnea (CSA), and obstructive sleep apnea (OSA) in chronic pain patients on opioids as well as methadone maintained patients (MMPs)."4.93A narrative review: The effects of opioids on sleep disordered breathing in chronic pain patients and methadone maintained patients. ( Hassamal, S; Miotto, K; Saxon, AJ; Wang, T, 2016)
"Buprenorphine is a semisynthetic opioid, a partial mu-opioid agonist with limited respiratory toxicity preferably used by these patients, as it is accompanied by significantly lower risk factors in the development of obstructive and central sleep apnea."1.62The effect of buprenorphine vs methadone on sleep breathing disorders. ( Adimi Naghan, P; Malekmohammad, M; Setareh, J, 2021)
"Methadone maintenance treatment (MMT) patients have a high prevalence of central sleep apnea and ataxic breathing related to damage to central respiratory rhythm control."1.43Respiratory Variability during Sleep in Methadone Maintenance Treatment Patients. ( Grunstein, RR; Kim, JW; Nguyen, CD; Thamrin, C; Wang, D, 2016)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's1 (10.00)18.2507
2000's2 (20.00)29.6817
2010's5 (50.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Adimi Naghan, P1
Setareh, J1
Malekmohammad, M1
Webster, LR2
Nguyen, CD1
Kim, JW1
Grunstein, RR1
Thamrin, C1
Wang, D1
Hassamal, S1
Miotto, K1
Wang, T1
Saxon, AJ1
Charpentier, A1
Bisac, S1
Poirot, I1
Vignau, J1
Cottencin, O1
Cochella, S1
Dasgupta, N1
Fakata, KL1
Fine, PG1
Fishman, SM1
Grey, T1
Johnson, EM1
Lee, LK1
Passik, SD1
Peppin, J1
Porucznik, CA1
Ray, A1
Schnoll, SH1
Stieg, RL1
Wakeland, W1
Farahmand, N1
Drennan, D1
Junkins, S1
Harrison, P1
Teichtahl, H1
Prodromidis, A1
Miller, B1
Cherry, G1
Kronborg, I1
Ward, SL1
Schuetz, S1
Kirshna, V1
Bean, X1
Wingert, W1
Wachsman, L1
Keens, TG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Efficacy and Mechanisms of a Novel Intervention for Chronic Pain Tailored to People Living With HIV[NCT03692611]280 participants (Actual)Interventional2019-08-14Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for methadone and Apnea, Sleep

ArticleYear
A narrative review: The effects of opioids on sleep disordered breathing in chronic pain patients and methadone maintained patients.
    The American journal on addictions, 2016, Volume: 25, Issue:6

    Topics: Analgesics, Opioid; Chronic Pain; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related D

2016

Other Studies

9 other studies available for methadone and Apnea, Sleep

ArticleYear
The effect of buprenorphine vs methadone on sleep breathing disorders.
    Advances in respiratory medicine, 2021, Volume: 89, Issue:4

    Topics: Adult; Buprenorphine; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Middle Aged

2021
Eight principles for safer opioid prescribing.
    Pain medicine (Malden, Mass.), 2013, Volume: 14, Issue:7

    Topics: Acute Pain; Analgesics, Opioid; Asthma; Benzodiazepines; Chronic Pain; Delayed-Action Preparations;

2013
Respiratory Variability during Sleep in Methadone Maintenance Treatment Patients.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2016, Apr-15, Volume: 12, Issue:4

    Topics: Adult; Analgesics, Opioid; Female; Humans; Male; Methadone; Opiate Substitution Treatment; Polysomno

2016
Sleep quality and apnea in stable methadone maintenance treatment.
    Substance use & misuse, 2010, Volume: 45, Issue:9

    Topics: Adult; Ambulatory Care; Female; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Narcotics;

2010
An analysis of the root causes for opioid-related overdose deaths in the United States.
    Pain medicine (Malden, Mass.), 2011, Volume: 12 Suppl 2

    Topics: Analgesics, Opioid; Comorbidity; Databases, Factual; Drug Overdose; Humans; Medication Errors; Metha

2011
Patient education and self-advocacy: queries and responses on pain management.
    Journal of pain & palliative care pharmacotherapy, 2008, Volume: 22, Issue:4

    Topics: Caffeine; Chronic Pain; Headache; Humans; Methadone; Pain Management; Sleep Apnea Syndromes

2008
Scientific presentations at Royal College meeting take look at medicine's bottom line.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1995, Dec-15, Volume: 153, Issue:12

    Topics: Analgesics, Opioid; Canada; Clinical Medicine; Computers; Hemorrhoids; Humans; Methadone; Misoprosto

1995
Sleep-disordered breathing in stable methadone programme patients: a pilot study.
    Addiction (Abingdon, England), 2001, Volume: 96, Issue:3

    Topics: Adult; Body Mass Index; Case-Control Studies; Depression; Female; Health Status; Heroin Dependence;

2001
Abnormal sleeping ventilatory pattern in infants of substance-abusing mothers.
    American journal of diseases of children (1960), 1986, Volume: 140, Issue:10

    Topics: Age Factors; Cocaine; Female; Heart Rate; Heroin; Humans; Infant; Male; Methadone; Narcotics; Phency

1986