Page last updated: 2024-10-30

methadone and Anxiety

methadone has been researched along with Anxiety in 75 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
"This research evaluated the efficacy of an Anxiety Reduction program designed to reduce anxiety early in methadone detoxification and thereby facilitate dose reduction."9.05Methadone dose decreases and anxiety reduction. ( Hall, SM; Kushner, M; Loeb, PC, 1984)
" The objective of this study was to examine the prevalence and correlates of suicide attempt in Chinese individuals receiving methadone maintenance treatment for heroin dependence."7.91Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence. ( Chen, H; Lu, J; Xie, WX; Zhong, BL; Zhu, JH, 2019)
"This study was designed to examine whether treadmill exercise would attenuate the severity of physical dependence, methadone-induced anxiety, depression and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment (MMT)."7.88Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment. ( Alizadeh, M; Miladi-Gorji, H; Zahedi-Khorasani, M, 2018)
"A considerable proportion of methadone maintenance treatment clients in China have experienced depression and anxiety during treatment."7.81Factors associated with depression and anxiety among patients attending community-based methadone maintenance treatment in China. ( Cao, X; Li, J; Li, Z; Liu, M; McGoogan, JM; Pang, L; Rou, K; Yin, W; Zhang, C, 2015)
"Methadone Maintenance Treatment (MMT) can be associated with severe stress and mild to moderate depressive symptoms."7.30The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. ( Bateni, A; Goli, R; Lagzi, N; Talebiazar, N, 2023)
"Methadone patients had lower baseline MHPG levels."6.70Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients. ( Charney, DS; Kosten, TR; Krystal, JH; Petrakis, IL; Southwick, SM; Stine, SM, 2002)
"Substance addiction is damaging to the health of persons, families, and society."6.49Spirituality, religiosity, depression, anxiety, and drug-use consequences during methadone maintenance therapy. ( Piacentine, LB, 2013)
"After 8-week intervention, crocin significantly decreased Beck Depression Inventory (b - 6."5.30The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial. ( Asemi, Z; Banafshe, HR; Ghaderi, A; Khalatbari-Mohseni, A; Mirhosseini, N; Omidi, A, 2019)
"According to this clinical trial, Olanzapine and Sertraline are effective in ameliorating symptoms of depression, anxiety and aggression, reducing sensitivity in interpersonal relationships and alleviating obsessive symptoms, pessimistic behaviors and somatization disorders in patients with personality disorders on methadone maintenance therapy."5.14The effect of Olanzapine and Sertraline on personality disorder in patients with methadone maintenance therapy. ( Birjandi, M; Jariani, M; Nazari, H; Saaki, M, 2010)
"Clonidine's actions and efficacy in mental disorders are reviewed and examined."5.06Psychiatric indications for clonidine: the neuropharmacologic and clinical basis. ( Bond, WS, 1986)
"This research evaluated the efficacy of an Anxiety Reduction program designed to reduce anxiety early in methadone detoxification and thereby facilitate dose reduction."5.05Methadone dose decreases and anxiety reduction. ( Hall, SM; Kushner, M; Loeb, PC, 1984)
"Prior studies indicate that subjects undergoing methadone maintenance therapy (MMT) may experience anxiety, depression and cravings."4.31Impact of combination of intermittent theta burst stimulation and methadone maintenance treatment in individuals with opioid use disorder: A comparative study. ( Cai, Z; Gong, H; Huang, J; Huang, Y; Jin, Y; Lu, W; Sun, X; Zhu, N; Zhu, X, 2023)
"Anxiety, an important factor that affects the therapeutic effect and preservation rate of methadone maintenance treatment, has a high prevalence among MMT patients."4.02Effects of treatment status and life quality on anxiety in MMT patients. ( Cao, P; Fan, N; Huang, Q; Xu, S; Zhang, Z; Zhong, J, 2021)
" The objective of this study was to examine the prevalence and correlates of suicide attempt in Chinese individuals receiving methadone maintenance treatment for heroin dependence."3.91Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence. ( Chen, H; Lu, J; Xie, WX; Zhong, BL; Zhu, JH, 2019)
"This study was designed to examine whether treadmill exercise would attenuate the severity of physical dependence, methadone-induced anxiety, depression and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment (MMT)."3.88Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment. ( Alizadeh, M; Miladi-Gorji, H; Zahedi-Khorasani, M, 2018)
"A considerable proportion of methadone maintenance treatment clients in China have experienced depression and anxiety during treatment."3.81Factors associated with depression and anxiety among patients attending community-based methadone maintenance treatment in China. ( Cao, X; Li, J; Li, Z; Liu, M; McGoogan, JM; Pang, L; Rou, K; Yin, W; Zhang, C, 2015)
"The depression score, the anxiety score and the level of interpersonal relationship sensitivity in 272 methadone maintenance treatment (1."3.81[Association between negative emotion and interpersonal sensitivity among patients in methadone maintenance treatment]. ( Deng, H; Li, J; Lu, Z; Xu, G; Yang, J, 2015)
"Benzodiazepines (BZD) misuse is a serious public health problem, especially among opiate-dependent patients with anxiety enrolled in methadone program because it puts patients at higher risk of life-threatening multiple drug overdoses."3.77Benzodiazepine use and misuse among patients in a methadone program. ( Berger, CC; Chen, KW; D'Adamo, C; Forde, DP; Gandhi, D; Weintraub, E, 2011)
" The current study assessed anxiety, depression, hostility and alexithymia levels in 70 methadone maintenance treatment patients."3.74Self-medication hypothesis of substance use: testing Khantzian's updated theory. ( Hall, DH; Queener, JE, 2007)
"Biofeedback was used as a means to relieve stress and anxiety for methadone patients."3.66Biofeedback application to drug addiction in the University of Colorado drug rehabilitation program. ( Brinkman, DN, 1978)
"Methadone Maintenance Treatment (MMT) can be associated with severe stress and mild to moderate depressive symptoms."3.30The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. ( Bateni, A; Goli, R; Lagzi, N; Talebiazar, N, 2023)
"Methadone patients had lower baseline MHPG levels."2.70Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients. ( Charney, DS; Kosten, TR; Krystal, JH; Petrakis, IL; Southwick, SM; Stine, SM, 2002)
"Withdrawal symptoms were the highest during the first assessment of the day, at the time of BUP administration."2.68A protocol to switch high-dose, methadone-maintained subjects to buprenorphine. ( Connerney, I; Fischman, MW; Foltin, RW; Levin, FR, 1997)
"Substance addiction is damaging to the health of persons, families, and society."2.49Spirituality, religiosity, depression, anxiety, and drug-use consequences during methadone maintenance therapy. ( Piacentine, LB, 2013)
"Personality is associated with substance use patterns and may be an appropriate target for intervention for those undergoing MMT to reduce opioid use, and potentially dangerous concurrent use of other drugs, while receiving methadone."1.51Specificity of personality relationships to particular forms of concurrent substance use among methadone maintenance therapy clients. ( Barrett, SP; Chinneck, A; Conrod, PJ; Laroque, F; Lawrence, M; Mahu, IT; Morin, JF; Nogueira-Arjona, R; Sako, A; Stewart, SH; Swansburg, J, 2019)
"The rate of opioid addiction, in particular, has been rising steadily in recent years, which necessitates deeper understanding of risk factors in order to develop effective prevention and treatment methods."1.46Intolerance of uncertainty in opioid dependency - Relationship with trait anxiety and impulsivity. ( Allen, MT; Frydecka, D; Garami, J; Haber, P; Misiak, B; Moustafa, AA; Myers, CE, 2017)
"Data analysis from observatory for pharmacodependency in ambulatory medicine survey (observation des pharmacodépendances en médecine ambulatoire [OPEMA]) program in 2013 of the subjects under high dosage buprenorphine (HDB) and methadone prescribed or obtained illegally reported by GPs in France."1.43[Characteristics of subjects under opiate maintenance treatment in primary care using the OPEMA data 2013]. ( Amaslidou, D; Frauger, E; Gentile, G; Giocanti, A; Micallef, J; Orleans, V; Pauly, V; Thirion, X, 2016)
"Recent clinical studies suggest that substance use may be associated with an acceleration of the ageing process, possibly related to a deficit of stem cell number or function."1.35An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey. ( Reece, AS, 2008)
"The SOWS measures withdrawal symptoms at the time of assessment."1.34Psychometric evaluation of the Dutch version of the Subjective Opiate Withdrawal Scale (SOWS). ( De Jong, CA; Dijkstra, BA; Krabbe, PF; Riezebos, TG; van der Staak, CP, 2007)
" In the unblocked condition, patients initially experienced an increase in positive mood, but with chronic administration there was a significant rise in psychopathology and the development of a generalized dysphoric state."1.26Psychopathology, craving, and mood during heroin acquisition: an experimental study. ( McDougle, M; McNamee, HB; Meyer, RE; Mirin, SM, 1976)

Research

Studies (75)

TimeframeStudies, this research(%)All Research%
pre-199033 (44.00)18.7374
1990's2 (2.67)18.2507
2000's9 (12.00)29.6817
2010's25 (33.33)24.3611
2020's6 (8.00)2.80

Authors

AuthorsStudies
Lagzi, N1
Bateni, A1
Goli, R1
Talebiazar, N1
Gong, H1
Huang, Y1
Zhu, X1
Lu, W1
Cai, Z1
Zhu, N1
Huang, J1
Jin, Y1
Sun, X1
Le, TA1
Le, MQT1
Dang, AD1
Dang, AK1
Nguyen, CT1
Pham, HQ1
Vu, GT1
Hoang, CL1
Tran, TT1
Vuong, QH1
Tran, TH1
Tran, BX1
Latkin, CA1
Ho, CSH1
Ho, RCM1
Zhong, BL2
Xie, WX1
Zhu, JH2
Lu, J1
Chen, H1
Gholami, M1
Saboory, E1
Ahmadi, AA1
Asouri, M1
Nasirikenari, M1
Rostamnezhad, M1
Jiang, H1
Su, H1
Zhang, C2
Liu, X1
Li, R1
Zhong, N1
Zhao, M1
Cao, P1
Zhang, Z1
Zhong, J1
Xu, S1
Huang, Q1
Fan, N1
Oliveira, C1
Filipe, R1
Meira, J1
Sampaio, L1
Teixeira, L1
Rodrigues, J1
Nunes, I1
Tavares, J1
Garami, J1
Haber, P2
Myers, CE1
Allen, MT1
Misiak, B1
Frydecka, D1
Moustafa, AA1
Yu, KC1
Wei, HT1
Yeh, YH1
Hsu, CH1
El Hage, C1
Ghabrash, MF1
Dubreucq, S1
Brissette, S1
Lespérance, F1
Lespérance, P1
Ouellet-Plamondon, C1
Bruneau, J1
Jutras-Aswad, D1
Alizadeh, M1
Zahedi-Khorasani, M1
Miladi-Gorji, H1
Ghaderi, A2
Banafshe, HR2
Mirhosseini, N2
Motmaen, M1
Mehrzad, F1
Bahmani, F1
Aghadavod, E1
Mansournia, MA1
Reiter, RJ1
Karimi, MA1
Asemi, Z2
Xu, YM1
Liu, XJ1
Taremian, F1
Nazari, S1
Moradveisi, L1
Moloodi, R1
Khalatbari-Mohseni, A1
Omidi, A1
Hallinan, R1
Elsayed, M1
Espinoza, D1
Veillard, AS1
Morley, KC1
Lintzeris, N1
Mahu, IT1
Conrod, PJ1
Barrett, SP1
Sako, A1
Swansburg, J1
Lawrence, M1
Laroque, F1
Morin, JF1
Chinneck, A1
Nogueira-Arjona, R1
Stewart, SH1
Piacentine, LB1
Sarfi, M1
Sundet, JM1
Waal, H1
Yin, W1
Pang, L1
Cao, X1
McGoogan, JM1
Liu, M1
Li, Z1
Li, J2
Rou, K1
Lee, CH1
Wang, TJ1
Tang, HP1
Liu, YH1
Bell, J1
Stevenson, E1
Cole, J1
Yang, J1
Xu, G1
Deng, H1
Lu, Z1
Smyth, BP1
Ducray, K1
Cullen, W1
Gentile, G1
Frauger, E1
Giocanti, A1
Pauly, V1
Orleans, V1
Amaslidou, D1
Thirion, X1
Micallef, J1
Jiao, M1
Gu, J1
Xu, H1
Hao, C1
Lau, JT1
Mo, P1
Liu, D1
Zhao, Y1
Zhang, X1
Babbitt, A1
Hao, Y1
Gao, Q1
Cheng, H1
Feng, JY1
Wang, B1
Reece, AS1
Elkader, AK1
Brands, B1
Callaghan, R1
Sproule, BA1
Jariani, M1
Saaki, M1
Nazari, H1
Birjandi, M1
Chen, KW1
Berger, CC1
Forde, DP1
D'Adamo, C1
Weintraub, E1
Gandhi, D1
Daly, FM1
Hughes, RN1
Woodward, LJ1
Benningfield, MM1
Dietrich, MS1
Jones, HE1
Kaltenbach, K1
Heil, SH1
Stine, SM2
Coyle, MG1
Arria, AM1
O'Grady, KE1
Fischer, G1
Martin, PR1
Howe, EG1
Dijkstra, BA1
Krabbe, PF1
Riezebos, TG1
van der Staak, CP1
De Jong, CA1
Hall, DH1
Queener, JE1
Shi, J1
Zhao, LY1
Copersino, ML1
Fang, YX1
Chen, Y1
Tian, J1
Deng, Y1
Shuai, Y1
Jin, J1
Lu, L1
Hall, SM2
Loeb, PC1
Kushner, M1
Hyndman, J1
Levin, FR1
Fischman, MW1
Connerney, I1
Foltin, RW1
Kolarzyk, E1
Targosz, D1
Pach, D1
Southwick, SM1
Petrakis, IL1
Kosten, TR1
Charney, DS1
Krystal, JH1
Watts, RJ1
Brinkman, DN1
Gold, MS1
Pottash, AL1
Sweeney, DR1
Kleber, HD1
Redmond, DE1
Steer, RA1
Gomez, E1
Mikhail, AR1
Ferris, GN1
Mirin, SM1
Meyer, RE1
McNamee, HB1
McDougle, M1
Lett, CR1
Wilson, JO1
Gambrell, A1
Woody, GE1
O'Brien, CP1
Rickels, K1
Spensley, J1
Peachey, JE1
Bond, WS1
Millman, RB1
Camí, J1
de Torres, S1
San, L1
Solé, A1
Guerra, D1
Ugena, B1
Haddox, VG1
Weissman, S1
Wallace, D1
Hiner, D1
Droppa, DC1
Khantzian, EJ1
Goldstein, A1
Berger, H1
Seljan, BJ1
Fisch, A1
Patch, VD1
Greenfield, A1
Raynes, AE1
McKenna, G1
Levine, M1
Jackman, JM1
Howe, LP1
Whitehead, CC1
Bralove, R1
Kelly, N1
Renteria, R1
Stein, A1
Blake, DA1
Distasio, C1
Robbins, PR1
Levine, DG1
Levin, DB1
Sloan, IH1
Chappel, JN1
Van Sloten, M1
Kinohi, RG1
Irwin, S1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Acceptability/Feasibility Testing of an Intervention Targeting Intolerance of Uncertainty[NCT05172427]45 participants (Anticipated)Interventional2021-09-15Recruiting
An Open-Label Pilot Study of Desvenlafaxine for Opioid-Dependent Patients With Comorbid Depression[NCT02200406]Phase 418 participants (Actual)Interventional2014-07-31Completed
Behavioral Intervention to Improve Insomnia Symptoms in Patients With Opioid Use Disorder[NCT05588726]0 participants (Actual)Interventional2022-01-01Withdrawn (stopped due to Staff no longer available to continue enrollment and other research activities)
Exploring the Utility and Safety of Benzodiazepine Prescribing Among People Receiving Opiate Replacement Therapy in Scotland (the BENZORT Study).[NCT04622995]46,899 participants (Actual)Observational2021-08-01Completed
Maternal Opioid Treatment: Human Experimental Research[NCT00271219]Phase 3175 participants (Actual)Interventional2005-07-31Completed
MOms in REcovery (MORE): Defining Optimal Care for Pregnant Women and Infants[NCT04251208]444 participants (Actual)Observational2019-07-30Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Child's Head Circumference Measurement (Measured at Birth)

(NCT00271219)
Timeframe: birth

Interventioncm (Mean)
A Methadone33.0
B Buprenorphine33.8

Child's Length of Hospital Stay

(NCT00271219)
Timeframe: delivery until hospital discharge (min=2 days, max=79 days)

Interventiondays (Mean)
A Methadone17.5
B Buprenorphine10.0

Child's Peak Daily Total NAS Score

NAS was measured with the MOTHER NAS scale, which includes 28 items, 19 of which are used for scoring and medication decisions. Scores can range from 0 to 42, with higher scores indicating more severe withdrawal. (NCT00271219)
Timeframe: minimum twice daily from birth until NAS no longer measured (min=10 days)

InterventionScore on the scale (Mean)
A Methadone12.8
B Buprenorphine11.0

Mother's HIV Risk Behaviors (Measured Monthly by Risk Behavior Assessment)

(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)

Interventionpercentage of HIV risk behaviors (Number)
A MethadoneNA
B BuprenorphineNA

Mother's Measures of Dose Adequacy and Acceptance Over Time (Measured Weekly by Dose Adequacy Measure)

Pregnant women maintained on an opioid agonist medication may require upward adjustment to their medication during the course of pregnant. The Dose Adequacy Measure represented a recordation of dosing adjustments during the course of the study. (NCT00271219)
Timeframe: from study entry until discontinuation or delivery (min=29 days, max=239 days)

Interventiondose increase per trimester (Number)
A MethadoneNA
B BuprenorphineNA

Mother's Psychosocial Functioning at Delivery as Measured by the Addiction Severity Index Psychosocial Index Score

The Addiction Severity Index is a structured clinical interview that assesses problem severity in 7 areas of functioning: alcohol use, drug use, medical, legal, employment, psychosocial, and psychiatric status. Each area of functioning yields a composite scale score between 0 and 1, with higher scores indicating greater problem severity in that area. Only the psychosocial index was examined in this study. (NCT00271219)
Timeframe: at delivery

InterventionScore on the scale (Mean)
Methadone.014
Buprenorphine.088

Mother's Self-report of Drug Use (Measured Monthly by Time Line Follow Back)

(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)

Interventionpercentage of drug use (Number)
A MethadoneNA
B BuprenorphineNA

Number of Children Requiring Treatment for Neonatal Abstinence Signs (NAS)

Neonatal abstinence syndrome (NAS) characterized by hyperirritability of the central nervous system and dysfunction in the autonomic nervous system, gastrointestinal tract, and respiratory system.11 When left untreated, NAS can result in serious illness (e.g., diarrhea, feeding difficulties, weight loss, and seizures) and death. (NCT00271219)
Timeframe: From birth until hospital discharge (min=4 days, max=10, depending on site)

Interventionparticipants (Number)
A Methadone41
B Buprenorphine27

Total Amount of Morphine Sulfate That a Neonate Receives to Treat NAS

Total amount in mg (NCT00271219)
Timeframe: Start of NAS treatment until discontinuation of NAS treatment (min=0 days, max=76 days)

Interventionmg (Mean)
A Methadone10.4
B Buprenorphine1.1

Reviews

3 reviews available for methadone and Anxiety

ArticleYear
Spirituality, religiosity, depression, anxiety, and drug-use consequences during methadone maintenance therapy.
    Western journal of nursing research, 2013, Volume: 35, Issue:6

    Topics: Anxiety; Depression; Evidence-Based Nursing; Humans; Methadone; Spirituality; Substance-Related Diso

2013
Behavioral treatment of drug addiction: a review and analysis.
    The International journal of the addictions, 1973, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Anxiety; Aversive Therapy; Behavior Therapy; Conditioning, Classical; Conditionin

1973
Opiate addiction: a critique of theory and some implications for treatment.
    American journal of psychotherapy, 1974, Volume: 28, Issue:1

    Topics: Aggression; Anger; Anxiety; Conditioning, Psychological; Depression; Euphoria; Humans; Methadone; Mo

1974

Trials

14 trials available for methadone and Anxiety

ArticleYear
The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial.
    International journal of psychiatry in medicine, 2023, Volume: 58, Issue:6

    Topics: Adult; Anxiety; Depression; Folic Acid; Humans; Male; Methadone; Middle Aged; Vitamins

2023
A pilot, open-label, 8-week study evaluating desvenlafaxine for treatment of major depression in methadone-maintained individuals with opioid use disorder.
    International clinical psychopharmacology, 2018, Volume: 33, Issue:5

    Topics: Adult; Antidepressive Agents; Anxiety; Craving; Depressive Disorder, Major; Desvenlafaxine Succinate

2018
The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment.
    Addiction biology, 2019, Volume: 24, Issue:4

    Topics: Adult; Analgesics, Opioid; Antioxidants; Anxiety; Blood Glucose; C-Reactive Protein; Cholesterol, HD

2019
Transcranial Direct Current Stimulation on Opium Craving, Depression, and Anxiety: A Preliminary Study.
    The journal of ECT, 2019, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Anxiety; Combined Modality Therapy; Craving; Depression; Humans; Male; Methadone;

2019
The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial.
    Substance abuse treatment, prevention, and policy, 2019, 02-22, Volume: 14, Issue:1

    Topics: Adult; Anxiety; Carotenoids; Depression; Double-Blind Method; Drug Therapy, Combination; Humans; Met

2019
The effect of Olanzapine and Sertraline on personality disorder in patients with methadone maintenance therapy.
    Psychiatria Danubina, 2010, Volume: 22, Issue:4

    Topics: Adult; Aggression; Analgesics, Opioid; Anxiety; Benzodiazepines; Borderline Personality Disorder; De

2010
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind

2012
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind

2012
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind

2012
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
    Addiction (Abingdon, England), 2012, Volume: 107 Suppl 1

    Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind

2012
PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users.
    European journal of pharmacology, 2008, Jan-28, Volume: 579, Issue:1-3

    Topics: Adult; Anxiety; Caudate Nucleus; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Hero

2008
Methadone dose decreases and anxiety reduction.
    Addictive behaviors, 1984, Volume: 9, Issue:1

    Topics: Adult; Anxiety; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Male; Methadone; Opioi

1984
A protocol to switch high-dose, methadone-maintained subjects to buprenorphine.
    The American journal on addictions, 1997,Spring, Volume: 6, Issue:2

    Topics: Adult; Anti-Anxiety Agents; Anxiety; Buprenorphine; Clonidine; Cocaine; Drug Administration Schedule

1997
An evaluation of breathing nervous regulation of opiate dependent patients during in 6 months' methadone maintenance treatment programme.
    Przeglad lekarski, 2001, Volume: 58, Issue:4

    Topics: Adult; Anxiety; Female; Humans; Lung; Male; Methadone; Middle Aged; Opioid-Related Disorders; Respir

2001
Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients.
    Biological psychiatry, 2002, Apr-15, Volume: 51, Issue:8

    Topics: Adrenergic alpha-Antagonists; Adult; Analgesics, Opioid; Anxiety; Blood Pressure; Double-Blind Metho

2002
Depression and anxiety in heroin addicts: a placebo-controlled study of doxepin in combination with methadone.
    The American journal of psychiatry, 1975, Volume: 132, Issue:4

    Topics: Administration, Oral; Adult; Alcoholic Intoxication; Amphetamine; Anxiety; Barbiturates; Capsules; C

1975
Psychiatric indications for clonidine: the neuropharmacologic and clinical basis.
    Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:2

    Topics: Animals; Anxiety; Bipolar Disorder; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug T

1986

Other Studies

58 other studies available for methadone and Anxiety

ArticleYear
Impact of combination of intermittent theta burst stimulation and methadone maintenance treatment in individuals with opioid use disorder: A comparative study.
    Psychiatry research, 2023, Volume: 327

    Topics: Anxiety; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Transcranial Ma

2023
Multi-level predictors of psychological problems among methadone maintenance treatment patients in difference types of settings in Vietnam.
    Substance abuse treatment, prevention, and policy, 2019, 09-18, Volume: 14, Issue:1

    Topics: Adult; Anxiety; Comorbidity; Cross-Sectional Studies; Depression; Humans; Male; Methadone; Middle Ag

2019
Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence.
    Scientific reports, 2019, 10-30, Volume: 9, Issue:1

    Topics: Adult; Antisocial Personality Disorder; Anxiety; China; Depressive Disorder, Major; Female; Heroin;

2019
Long-time effects of prenatal morphine, tramadol, methadone, and buprenorphine exposure on seizure and anxiety in immature rats.
    The International journal of neuroscience, 2020, Volume: 130, Issue:9

    Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Buprenorphine; Female; Locomotion; Male; Maze

2020
Challenges of methadone maintenance treatment during the COVID-19 epidemic in China: Policy and service recommendations.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2020, Volume: 35

    Topics: Ambulatory Care; Analgesics, Opioid; Anxiety; China; Coronavirus Infections; COVID-19; Delivery of H

2020
Effects of treatment status and life quality on anxiety in MMT patients.
    Substance abuse treatment, prevention, and policy, 2021, 01-13, Volume: 16, Issue:1

    Topics: Anxiety; China; Depression; Humans; Methadone; Opiate Substitution Treatment; Quality of Life

2021
Benzodiazepine Use in Opioid Maintenance Treatment Programme: Risks and Clinical Outcomes.
    Acta medica portuguesa, 2021, Mar-01, Volume: 34, Issue:3

    Topics: Adult; Analgesics, Opioid; Anxiety; Benzodiazepines; Buprenorphine; Cross-Sectional Studies; Diazepa

2021
Intolerance of uncertainty in opioid dependency - Relationship with trait anxiety and impulsivity.
    PloS one, 2017, Volume: 12, Issue:7

    Topics: Adult; Analgesics, Opioid; Anxiety; Case-Control Studies; Decision Making; Female; Heroin; Humans; I

2017
Traditional Chinese medicine-facilitated treatments may relieve anxiety symptoms during drug switching from methadone to buprenorphine/naloxone for treating opioid dependence.
    BMJ case reports, 2017, Nov-09, Volume: 2017

    Topics: Anxiety; Buprenorphine, Naloxone Drug Combination; Drug Substitution; Drugs, Chinese Herbal; Humans;

2017
Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment.
    Neuroscience letters, 2018, 08-10, Volume: 681

    Topics: Animals; Anxiety; Depression; Exercise Test; Male; Maze Learning; Methadone; Morphine; Morphine Depe

2018
Non-suicidal self-injury in Chinese heroin-dependent patients receiving methadone maintenance treatment: Prevalence and associated factors.
    Drug and alcohol dependence, 2018, 08-01, Volume: 189

    Topics: Adult; Anxiety; China; Cross-Sectional Studies; Depression; Female; Heroin Dependence; Humans; Lonel

2018
Insomnia and excessive daytime sleepiness in women and men receiving methadone and buprenorphine maintenance treatment.
    Substance use & misuse, 2019, Volume: 54, Issue:10

    Topics: Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Cross-Sectional Studies; Depression;

2019
Specificity of personality relationships to particular forms of concurrent substance use among methadone maintenance therapy clients.
    Addictive behaviors, 2019, Volume: 98

    Topics: Adult; Anxiety; Arousal; Comorbidity; Correlation of Data; Female; Hope; Humans; Male; Methadone; Mi

2019
Maternal stress and behavioral adaptation in methadone- or buprenorphine-exposed toddlers.
    Infant behavior & development, 2013, Volume: 36, Issue:4

    Topics: Adult; Anxiety; Buprenorphine; Child; Child, Preschool; Depression; Family; Female; Humans; Longitud

2013
Factors associated with depression and anxiety among patients attending community-based methadone maintenance treatment in China.
    Addiction (Abingdon, England), 2015, Volume: 110 Suppl 1

    Topics: Adult; Analgesics, Opioid; Anxiety; China; Comorbidity; Cross-Sectional Studies; Depression; Drug Us

2015
Familial expressed emotion among heroin addicts in methadone maintenance treatment: does it matter?
    Addictive behaviors, 2015, Volume: 45

    Topics: Adult; Anxiety; Depression; Expressed Emotion; Family; Female; Heroin Dependence; Humans; Male; Medi

2015
Associations between chronic non-cancer pain and medication assisted treatment outcomes for opiate addiction.
    The American journal on addictions, 2015, Volume: 24, Issue:2

    Topics: Adult; Anxiety; Chronic Pain; Comorbidity; Depression; Female; Humans; Kentucky; Male; Methadone; Op

2015
[Association between negative emotion and interpersonal sensitivity among patients in methadone maintenance treatment].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2015, Volume: 49, Issue:8

    Topics: Adult; Anxiety; Depression; Female; Humans; Interpersonal Relations; Male; Methadone; Middle Aged; O

2015
Changes in psychological well-being among heroin-dependent adolescents during psychologically supported opiate substitution treatment.
    Early intervention in psychiatry, 2018, Volume: 12, Issue:3

    Topics: Adolescent; Adolescent Behavior; Anger; Anxiety; Buprenorphine; Combined Modality Therapy; Depressio

2018
[Characteristics of subjects under opiate maintenance treatment in primary care using the OPEMA data 2013].
    Therapie, 2016, Volume: 71, Issue:3

    Topics: Adolescent; Adult; Alcohol Drinking; Anxiety; Benzodiazepines; Buprenorphine; Depressive Disorder; D

2016
Resilience associated with mental health problems among methadone maintenance treatment patients in Guangzhou, China.
    AIDS care, 2017, Volume: 29, Issue:5

    Topics: Adult; Anxiety; China; Depression; Female; Humans; Male; Mental Health; Methadone; Middle Aged; Opia

2017
[Study on anxiety and depression status among the methadone maintenance treatment patients in Wuxi, Jiangsu].
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2008, Volume: 29, Issue:3

    Topics: Anxiety; China; Depression; Female; Heroin Dependence; Humans; Male; Methadone

2008
An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey.
    British dental journal, 2008, Dec-13, Volume: 205, Issue:11

    Topics: Adolescent; Adult; Aggression; Aging; Alcohol Drinking; Amphetamine-Related Disorders; Anxiety; Atte

2008
Exploring the relationship between perceived inter-dose opioid withdrawal and patient characteristics in methadone maintenance treatment.
    Drug and alcohol dependence, 2009, Dec-01, Volume: 105, Issue:3

    Topics: Adult; Affect; Anxiety; Behavior, Addictive; Female; Humans; Male; Methadone; Opioid-Related Disorde

2009
Benzodiazepine use and misuse among patients in a methadone program.
    BMC psychiatry, 2011, May-19, Volume: 11

    Topics: Anxiety; Baltimore; Benzodiazepines; Female; Health Surveys; Humans; Male; Methadone; Middle Aged; O

2011
Subsequent anxiety-related behavior in rats exposed to low-dose methadone during gestation, lactation or both periods consecutively.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 102, Issue:2

    Topics: Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Female; Growth; Lactation; Met

2012
Do we undervalue feelings in patients who are cognitively impaired?
    The Journal of clinical ethics, 2006,Winter, Volume: 17, Issue:4

    Topics: Aggression; Alzheimer Disease; Analgesics, Opioid; Anger; Anxiety; Brain Injuries; Cognition; Cognit

2006
Psychometric evaluation of the Dutch version of the Subjective Opiate Withdrawal Scale (SOWS).
    European addiction research, 2007, Volume: 13, Issue:2

    Topics: Adult; Anxiety; Body Temperature; Body Temperature Regulation; Facial Expression; Heroin Dependence;

2007
Self-medication hypothesis of substance use: testing Khantzian's updated theory.
    Journal of psychoactive drugs, 2007, Volume: 39, Issue:2

    Topics: Adult; Affect; Affective Symptoms; Anxiety; Behavior, Addictive; Depression; Female; Hostility; Huma

2007
Oral premedication with methadone, promethazine and diclofenac.
    Anaesthesia and intensive care, 1993, Volume: 21, Issue:2

    Topics: Administration, Oral; Anxiety; Diclofenac; Female; Humans; Male; Methadone; Pain, Postoperative; Pre

1993
The physiological interrelationships between depression, drugs, and sexuality.
    Nursing forum, 1978, Volume: 17, Issue:2

    Topics: Antihypertensive Agents; Anxiety; Cannabis; Contraceptives, Oral; Depression; Ethanol; Female; Genit

1978
The abstinence phobia.
    NIDA research monograph, 1979, Issue:25

    Topics: Adaptation, Psychological; Anxiety; Heroin; Heroin Dependence; Humans; Methadone; Phobic Disorders;

1979
Biofeedback application to drug addiction in the University of Colorado drug rehabilitation program.
    The International journal of the addictions, 1978, Volume: 13, Issue:5

    Topics: Anxiety; Biofeedback, Psychology; Colorado; Costs and Cost Analysis; Electromyography; Heroin Depend

1978
Rapid opiate detoxification: clinical evidence of antidepressant and antipanic effects of opiates.
    The American journal of psychiatry, 1979, Volume: 136, Issue:7

    Topics: Adult; Anxiety; Clonidine; Depression; Drug Therapy, Combination; Fear; Humans; Imipramine; Male; Me

1979
Differences in heroin addicts seeking inpatient detoxification, ambulatory detoxification, or methadone maintenance.
    Drug and alcohol dependence, 1979, Volume: 4, Issue:5

    Topics: Adult; Ambulatory Care; Anxiety; Community Mental Health Services; Female; Heroin Dependence; Humans

1979
Treatment of methadone withdrawal with cerebral electrotherapy (electrosleep).
    The British journal of psychiatry : the journal of mental science, 1979, Volume: 134

    Topics: Adolescent; Adult; Anxiety; Electronarcosis; Evaluation Studies as Topic; Heroin Dependence; Humans;

1979
Psychotropic drugs in opioid addicts on methadone treatment.
    Diseases of the nervous system, 1976, Volume: 37, Issue:7

    Topics: Adult; Anxiety; Depression; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Male; Meth

1976
Psychopathology, craving, and mood during heroin acquisition: an experimental study.
    The International journal of the addictions, 1976, Volume: 11, Issue:3

    Topics: Adult; Aggression; Anxiety; Depression; Drive; Emotions; Heroin; Heroin Dependence; Hostility; Human

1976
Effect of neurotone therapy during methadone detoxification.
    The International journal of the addictions, 1976, Volume: 11, Issue:1

    Topics: Adult; Anxiety; Electric Stimulation Therapy; Female; Heroin Dependence; Humans; Male; Methadone; Mi

1976
Doxepin: a useful adjunct in the treatment of heroin addicts in a methadone program.
    The International journal of the addictions, 1976, Volume: 11, Issue:1

    Topics: Adult; Aged; Anxiety; California; Doxepin; Female; Heroin Dependence; Humans; Male; Methadone; Middl

1976
The role of drugs in the treatment of opioid addicts.
    The Medical journal of Australia, 1986, Oct-20, Volume: 145, Issue:8

    Topics: Alcoholism; Anxiety; Clonidine; Dextropropoxyphene; Heroin; Humans; Inactivation, Metabolic; Kinetic

1986
Considerations on the psychotherapy of the substance abuser.
    Journal of substance abuse treatment, 1986, Volume: 3, Issue:2

    Topics: Adult; Alcoholics Anonymous; Alcoholism; Anxiety; Cocaine; Female; Humans; Male; Methadone; Middle A

1986
Efficacy of clonidine and of methadone in the rapid detoxification of patients dependent on heroin.
    Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:3

    Topics: Adolescent; Adult; Analysis of Variance; Anxiety; Blood Pressure; Clonidine; Double-Blind Method; Dr

1985
Psychological adjustment--mood and personality fluctuations of long-term methadone maintenance patients.
    The International journal of the addictions, 1972, Volume: 7, Issue:4

    Topics: Adult; Anxiety; Counseling; Depression; Evaluation Studies as Topic; Female; Hawaii; Heroin; Hostili

1972
The significance of diagnosis in the treatment of narcotics addicts.
    The International journal of the addictions, 1970, Volume: 5, Issue:4

    Topics: Adult; Anxiety; Community Health Services; Depression; Evaluation Studies as Topic; Heroin; Humans;

1970
Some descriptive measures on 100 consecutive VA hospital drug abuse admissions.
    The International journal of the addictions, 1974, Volume: 9, Issue:3

    Topics: Adolescent; Adult; Amphetamine; Antisocial Personality Disorder; Anxiety; Barbiturates; Depression;

1974
Heroin addiction and the role of methadone in its treatment.
    Archives of general psychiatry, 1972, Volume: 26, Issue:4

    Topics: Animals; Anxiety; Compulsive Behavior; Conditioning, Classical; Conditioning, Operant; Dogs; Drug To

1972
Methadone maintenance programs.
    Postgraduate medicine, 1973, Volume: 54, Issue:4

    Topics: Anxiety; Crime; Heroin; Heroin Dependence; Humans; Legislation as Topic; Methadone; Motivation; Subs

1973
The transfer of administration and operation of an ongoing methadone maintenance program.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 1

    Topics: Anxiety; Attitude of Health Personnel; California; Community Mental Health Services; Heroin Dependen

1973
Internal indicators for the management and prognosis of patients in a methadone maintenance program (internal states self-report scale).
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 1

    Topics: Adult; Anxiety; Depression; Female; Heroin Dependence; Humans; Male; Methadone; Personality Assessme

1973
A hypothesis concerning the difficulty of withdrawal from maintenance on methadone.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 1

    Topics: Anxiety; California; Community Health Services; Female; Heroin Dependence; Humans; Male; Methadone;

1973
Methadone and mortality: toward a sociology of addiction.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 1

    Topics: Anxiety; Heroin Dependence; Humans; Methadone; Morals; Sociology

1973
Methadone pseudowithdrawal: etiological considerations.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 1

    Topics: Anxiety; Depression; Diagnosis, Differential; Heroin Dependence; Humans; Methadone; Substance Withdr

1973
The effect of a change in milieu on patient progress in methadone maintainance.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Anxiety; Environment; Frustration; Heroin Dependence; Humans; Methadone; Milieu Therapy; New York Ci

1973
A comparison of level of anxiety, depression and hostility with methadone plasma concentration in opioid-dependent patients receiving methadone on a maintenance dosage schedule.
    Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2

    Topics: Anxiety; Community Health Services; Depression; Female; Heroin Dependence; Hostility; Humans; Male;

1973
Methadone dose and emotional states in drug-addicted patients.
    Journal of clinical psychology, 1974, Volume: 30, Issue:3

    Topics: Adult; Affective Symptoms; Anxiety; Depression; Dose-Response Relationship, Drug; Heroin Dependence;

1974
Personality correlates of success in a methadone maintenance program.
    The American journal of psychiatry, 1972, Volume: 129, Issue:4

    Topics: Adult; Anxiety; Black or African American; Community Health Services; Cooperative Behavior; Counseli

1972
Drug effects on the foot shock-induced behavior of paired mice.
    Proceedings of the Western Pharmacology Society, 1968, Volume: 11

    Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Electroshock; Foot; Hostility; Humans; Hy

1968