methadone has been researched along with Anxiety in 75 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This research evaluated the efficacy of an Anxiety Reduction program designed to reduce anxiety early in methadone detoxification and thereby facilitate dose reduction." | 9.05 | Methadone dose decreases and anxiety reduction. ( Hall, SM; Kushner, M; Loeb, PC, 1984) |
| " The objective of this study was to examine the prevalence and correlates of suicide attempt in Chinese individuals receiving methadone maintenance treatment for heroin dependence." | 7.91 | Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence. ( Chen, H; Lu, J; Xie, WX; Zhong, BL; Zhu, JH, 2019) |
| "This study was designed to examine whether treadmill exercise would attenuate the severity of physical dependence, methadone-induced anxiety, depression and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment (MMT)." | 7.88 | Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment. ( Alizadeh, M; Miladi-Gorji, H; Zahedi-Khorasani, M, 2018) |
| "A considerable proportion of methadone maintenance treatment clients in China have experienced depression and anxiety during treatment." | 7.81 | Factors associated with depression and anxiety among patients attending community-based methadone maintenance treatment in China. ( Cao, X; Li, J; Li, Z; Liu, M; McGoogan, JM; Pang, L; Rou, K; Yin, W; Zhang, C, 2015) |
| "Methadone Maintenance Treatment (MMT) can be associated with severe stress and mild to moderate depressive symptoms." | 7.30 | The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. ( Bateni, A; Goli, R; Lagzi, N; Talebiazar, N, 2023) |
| "Methadone patients had lower baseline MHPG levels." | 6.70 | Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients. ( Charney, DS; Kosten, TR; Krystal, JH; Petrakis, IL; Southwick, SM; Stine, SM, 2002) |
| "Substance addiction is damaging to the health of persons, families, and society." | 6.49 | Spirituality, religiosity, depression, anxiety, and drug-use consequences during methadone maintenance therapy. ( Piacentine, LB, 2013) |
| "After 8-week intervention, crocin significantly decreased Beck Depression Inventory (b - 6." | 5.30 | The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial. ( Asemi, Z; Banafshe, HR; Ghaderi, A; Khalatbari-Mohseni, A; Mirhosseini, N; Omidi, A, 2019) |
| "According to this clinical trial, Olanzapine and Sertraline are effective in ameliorating symptoms of depression, anxiety and aggression, reducing sensitivity in interpersonal relationships and alleviating obsessive symptoms, pessimistic behaviors and somatization disorders in patients with personality disorders on methadone maintenance therapy." | 5.14 | The effect of Olanzapine and Sertraline on personality disorder in patients with methadone maintenance therapy. ( Birjandi, M; Jariani, M; Nazari, H; Saaki, M, 2010) |
| "Clonidine's actions and efficacy in mental disorders are reviewed and examined." | 5.06 | Psychiatric indications for clonidine: the neuropharmacologic and clinical basis. ( Bond, WS, 1986) |
| "This research evaluated the efficacy of an Anxiety Reduction program designed to reduce anxiety early in methadone detoxification and thereby facilitate dose reduction." | 5.05 | Methadone dose decreases and anxiety reduction. ( Hall, SM; Kushner, M; Loeb, PC, 1984) |
| "Prior studies indicate that subjects undergoing methadone maintenance therapy (MMT) may experience anxiety, depression and cravings." | 4.31 | Impact of combination of intermittent theta burst stimulation and methadone maintenance treatment in individuals with opioid use disorder: A comparative study. ( Cai, Z; Gong, H; Huang, J; Huang, Y; Jin, Y; Lu, W; Sun, X; Zhu, N; Zhu, X, 2023) |
| "Anxiety, an important factor that affects the therapeutic effect and preservation rate of methadone maintenance treatment, has a high prevalence among MMT patients." | 4.02 | Effects of treatment status and life quality on anxiety in MMT patients. ( Cao, P; Fan, N; Huang, Q; Xu, S; Zhang, Z; Zhong, J, 2021) |
| " The objective of this study was to examine the prevalence and correlates of suicide attempt in Chinese individuals receiving methadone maintenance treatment for heroin dependence." | 3.91 | Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence. ( Chen, H; Lu, J; Xie, WX; Zhong, BL; Zhu, JH, 2019) |
| "This study was designed to examine whether treadmill exercise would attenuate the severity of physical dependence, methadone-induced anxiety, depression and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment (MMT)." | 3.88 | Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment. ( Alizadeh, M; Miladi-Gorji, H; Zahedi-Khorasani, M, 2018) |
| "A considerable proportion of methadone maintenance treatment clients in China have experienced depression and anxiety during treatment." | 3.81 | Factors associated with depression and anxiety among patients attending community-based methadone maintenance treatment in China. ( Cao, X; Li, J; Li, Z; Liu, M; McGoogan, JM; Pang, L; Rou, K; Yin, W; Zhang, C, 2015) |
| "The depression score, the anxiety score and the level of interpersonal relationship sensitivity in 272 methadone maintenance treatment (1." | 3.81 | [Association between negative emotion and interpersonal sensitivity among patients in methadone maintenance treatment]. ( Deng, H; Li, J; Lu, Z; Xu, G; Yang, J, 2015) |
| "Benzodiazepines (BZD) misuse is a serious public health problem, especially among opiate-dependent patients with anxiety enrolled in methadone program because it puts patients at higher risk of life-threatening multiple drug overdoses." | 3.77 | Benzodiazepine use and misuse among patients in a methadone program. ( Berger, CC; Chen, KW; D'Adamo, C; Forde, DP; Gandhi, D; Weintraub, E, 2011) |
| " The current study assessed anxiety, depression, hostility and alexithymia levels in 70 methadone maintenance treatment patients." | 3.74 | Self-medication hypothesis of substance use: testing Khantzian's updated theory. ( Hall, DH; Queener, JE, 2007) |
| "Biofeedback was used as a means to relieve stress and anxiety for methadone patients." | 3.66 | Biofeedback application to drug addiction in the University of Colorado drug rehabilitation program. ( Brinkman, DN, 1978) |
| "Methadone Maintenance Treatment (MMT) can be associated with severe stress and mild to moderate depressive symptoms." | 3.30 | The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. ( Bateni, A; Goli, R; Lagzi, N; Talebiazar, N, 2023) |
| "Methadone patients had lower baseline MHPG levels." | 2.70 | Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients. ( Charney, DS; Kosten, TR; Krystal, JH; Petrakis, IL; Southwick, SM; Stine, SM, 2002) |
| "Withdrawal symptoms were the highest during the first assessment of the day, at the time of BUP administration." | 2.68 | A protocol to switch high-dose, methadone-maintained subjects to buprenorphine. ( Connerney, I; Fischman, MW; Foltin, RW; Levin, FR, 1997) |
| "Substance addiction is damaging to the health of persons, families, and society." | 2.49 | Spirituality, religiosity, depression, anxiety, and drug-use consequences during methadone maintenance therapy. ( Piacentine, LB, 2013) |
| "Personality is associated with substance use patterns and may be an appropriate target for intervention for those undergoing MMT to reduce opioid use, and potentially dangerous concurrent use of other drugs, while receiving methadone." | 1.51 | Specificity of personality relationships to particular forms of concurrent substance use among methadone maintenance therapy clients. ( Barrett, SP; Chinneck, A; Conrod, PJ; Laroque, F; Lawrence, M; Mahu, IT; Morin, JF; Nogueira-Arjona, R; Sako, A; Stewart, SH; Swansburg, J, 2019) |
| "The rate of opioid addiction, in particular, has been rising steadily in recent years, which necessitates deeper understanding of risk factors in order to develop effective prevention and treatment methods." | 1.46 | Intolerance of uncertainty in opioid dependency - Relationship with trait anxiety and impulsivity. ( Allen, MT; Frydecka, D; Garami, J; Haber, P; Misiak, B; Moustafa, AA; Myers, CE, 2017) |
| "Data analysis from observatory for pharmacodependency in ambulatory medicine survey (observation des pharmacodépendances en médecine ambulatoire [OPEMA]) program in 2013 of the subjects under high dosage buprenorphine (HDB) and methadone prescribed or obtained illegally reported by GPs in France." | 1.43 | [Characteristics of subjects under opiate maintenance treatment in primary care using the OPEMA data 2013]. ( Amaslidou, D; Frauger, E; Gentile, G; Giocanti, A; Micallef, J; Orleans, V; Pauly, V; Thirion, X, 2016) |
| "Recent clinical studies suggest that substance use may be associated with an acceleration of the ageing process, possibly related to a deficit of stem cell number or function." | 1.35 | An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey. ( Reece, AS, 2008) |
| "The SOWS measures withdrawal symptoms at the time of assessment." | 1.34 | Psychometric evaluation of the Dutch version of the Subjective Opiate Withdrawal Scale (SOWS). ( De Jong, CA; Dijkstra, BA; Krabbe, PF; Riezebos, TG; van der Staak, CP, 2007) |
| " In the unblocked condition, patients initially experienced an increase in positive mood, but with chronic administration there was a significant rise in psychopathology and the development of a generalized dysphoric state." | 1.26 | Psychopathology, craving, and mood during heroin acquisition: an experimental study. ( McDougle, M; McNamee, HB; Meyer, RE; Mirin, SM, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (44.00) | 18.7374 |
| 1990's | 2 (2.67) | 18.2507 |
| 2000's | 9 (12.00) | 29.6817 |
| 2010's | 25 (33.33) | 24.3611 |
| 2020's | 6 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lagzi, N | 1 |
| Bateni, A | 1 |
| Goli, R | 1 |
| Talebiazar, N | 1 |
| Gong, H | 1 |
| Huang, Y | 1 |
| Zhu, X | 1 |
| Lu, W | 1 |
| Cai, Z | 1 |
| Zhu, N | 1 |
| Huang, J | 1 |
| Jin, Y | 1 |
| Sun, X | 1 |
| Le, TA | 1 |
| Le, MQT | 1 |
| Dang, AD | 1 |
| Dang, AK | 1 |
| Nguyen, CT | 1 |
| Pham, HQ | 1 |
| Vu, GT | 1 |
| Hoang, CL | 1 |
| Tran, TT | 1 |
| Vuong, QH | 1 |
| Tran, TH | 1 |
| Tran, BX | 1 |
| Latkin, CA | 1 |
| Ho, CSH | 1 |
| Ho, RCM | 1 |
| Zhong, BL | 2 |
| Xie, WX | 1 |
| Zhu, JH | 2 |
| Lu, J | 1 |
| Chen, H | 1 |
| Gholami, M | 1 |
| Saboory, E | 1 |
| Ahmadi, AA | 1 |
| Asouri, M | 1 |
| Nasirikenari, M | 1 |
| Rostamnezhad, M | 1 |
| Jiang, H | 1 |
| Su, H | 1 |
| Zhang, C | 2 |
| Liu, X | 1 |
| Li, R | 1 |
| Zhong, N | 1 |
| Zhao, M | 1 |
| Cao, P | 1 |
| Zhang, Z | 1 |
| Zhong, J | 1 |
| Xu, S | 1 |
| Huang, Q | 1 |
| Fan, N | 1 |
| Oliveira, C | 1 |
| Filipe, R | 1 |
| Meira, J | 1 |
| Sampaio, L | 1 |
| Teixeira, L | 1 |
| Rodrigues, J | 1 |
| Nunes, I | 1 |
| Tavares, J | 1 |
| Garami, J | 1 |
| Haber, P | 2 |
| Myers, CE | 1 |
| Allen, MT | 1 |
| Misiak, B | 1 |
| Frydecka, D | 1 |
| Moustafa, AA | 1 |
| Yu, KC | 1 |
| Wei, HT | 1 |
| Yeh, YH | 1 |
| Hsu, CH | 1 |
| El Hage, C | 1 |
| Ghabrash, MF | 1 |
| Dubreucq, S | 1 |
| Brissette, S | 1 |
| Lespérance, F | 1 |
| Lespérance, P | 1 |
| Ouellet-Plamondon, C | 1 |
| Bruneau, J | 1 |
| Jutras-Aswad, D | 1 |
| Alizadeh, M | 1 |
| Zahedi-Khorasani, M | 1 |
| Miladi-Gorji, H | 1 |
| Ghaderi, A | 2 |
| Banafshe, HR | 2 |
| Mirhosseini, N | 2 |
| Motmaen, M | 1 |
| Mehrzad, F | 1 |
| Bahmani, F | 1 |
| Aghadavod, E | 1 |
| Mansournia, MA | 1 |
| Reiter, RJ | 1 |
| Karimi, MA | 1 |
| Asemi, Z | 2 |
| Xu, YM | 1 |
| Liu, XJ | 1 |
| Taremian, F | 1 |
| Nazari, S | 1 |
| Moradveisi, L | 1 |
| Moloodi, R | 1 |
| Khalatbari-Mohseni, A | 1 |
| Omidi, A | 1 |
| Hallinan, R | 1 |
| Elsayed, M | 1 |
| Espinoza, D | 1 |
| Veillard, AS | 1 |
| Morley, KC | 1 |
| Lintzeris, N | 1 |
| Mahu, IT | 1 |
| Conrod, PJ | 1 |
| Barrett, SP | 1 |
| Sako, A | 1 |
| Swansburg, J | 1 |
| Lawrence, M | 1 |
| Laroque, F | 1 |
| Morin, JF | 1 |
| Chinneck, A | 1 |
| Nogueira-Arjona, R | 1 |
| Stewart, SH | 1 |
| Piacentine, LB | 1 |
| Sarfi, M | 1 |
| Sundet, JM | 1 |
| Waal, H | 1 |
| Yin, W | 1 |
| Pang, L | 1 |
| Cao, X | 1 |
| McGoogan, JM | 1 |
| Liu, M | 1 |
| Li, Z | 1 |
| Li, J | 2 |
| Rou, K | 1 |
| Lee, CH | 1 |
| Wang, TJ | 1 |
| Tang, HP | 1 |
| Liu, YH | 1 |
| Bell, J | 1 |
| Stevenson, E | 1 |
| Cole, J | 1 |
| Yang, J | 1 |
| Xu, G | 1 |
| Deng, H | 1 |
| Lu, Z | 1 |
| Smyth, BP | 1 |
| Ducray, K | 1 |
| Cullen, W | 1 |
| Gentile, G | 1 |
| Frauger, E | 1 |
| Giocanti, A | 1 |
| Pauly, V | 1 |
| Orleans, V | 1 |
| Amaslidou, D | 1 |
| Thirion, X | 1 |
| Micallef, J | 1 |
| Jiao, M | 1 |
| Gu, J | 1 |
| Xu, H | 1 |
| Hao, C | 1 |
| Lau, JT | 1 |
| Mo, P | 1 |
| Liu, D | 1 |
| Zhao, Y | 1 |
| Zhang, X | 1 |
| Babbitt, A | 1 |
| Hao, Y | 1 |
| Gao, Q | 1 |
| Cheng, H | 1 |
| Feng, JY | 1 |
| Wang, B | 1 |
| Reece, AS | 1 |
| Elkader, AK | 1 |
| Brands, B | 1 |
| Callaghan, R | 1 |
| Sproule, BA | 1 |
| Jariani, M | 1 |
| Saaki, M | 1 |
| Nazari, H | 1 |
| Birjandi, M | 1 |
| Chen, KW | 1 |
| Berger, CC | 1 |
| Forde, DP | 1 |
| D'Adamo, C | 1 |
| Weintraub, E | 1 |
| Gandhi, D | 1 |
| Daly, FM | 1 |
| Hughes, RN | 1 |
| Woodward, LJ | 1 |
| Benningfield, MM | 1 |
| Dietrich, MS | 1 |
| Jones, HE | 1 |
| Kaltenbach, K | 1 |
| Heil, SH | 1 |
| Stine, SM | 2 |
| Coyle, MG | 1 |
| Arria, AM | 1 |
| O'Grady, KE | 1 |
| Fischer, G | 1 |
| Martin, PR | 1 |
| Howe, EG | 1 |
| Dijkstra, BA | 1 |
| Krabbe, PF | 1 |
| Riezebos, TG | 1 |
| van der Staak, CP | 1 |
| De Jong, CA | 1 |
| Hall, DH | 1 |
| Queener, JE | 1 |
| Shi, J | 1 |
| Zhao, LY | 1 |
| Copersino, ML | 1 |
| Fang, YX | 1 |
| Chen, Y | 1 |
| Tian, J | 1 |
| Deng, Y | 1 |
| Shuai, Y | 1 |
| Jin, J | 1 |
| Lu, L | 1 |
| Hall, SM | 2 |
| Loeb, PC | 1 |
| Kushner, M | 1 |
| Hyndman, J | 1 |
| Levin, FR | 1 |
| Fischman, MW | 1 |
| Connerney, I | 1 |
| Foltin, RW | 1 |
| Kolarzyk, E | 1 |
| Targosz, D | 1 |
| Pach, D | 1 |
| Southwick, SM | 1 |
| Petrakis, IL | 1 |
| Kosten, TR | 1 |
| Charney, DS | 1 |
| Krystal, JH | 1 |
| Watts, RJ | 1 |
| Brinkman, DN | 1 |
| Gold, MS | 1 |
| Pottash, AL | 1 |
| Sweeney, DR | 1 |
| Kleber, HD | 1 |
| Redmond, DE | 1 |
| Steer, RA | 1 |
| Gomez, E | 1 |
| Mikhail, AR | 1 |
| Ferris, GN | 1 |
| Mirin, SM | 1 |
| Meyer, RE | 1 |
| McNamee, HB | 1 |
| McDougle, M | 1 |
| Lett, CR | 1 |
| Wilson, JO | 1 |
| Gambrell, A | 1 |
| Woody, GE | 1 |
| O'Brien, CP | 1 |
| Rickels, K | 1 |
| Spensley, J | 1 |
| Peachey, JE | 1 |
| Bond, WS | 1 |
| Millman, RB | 1 |
| Camí, J | 1 |
| de Torres, S | 1 |
| San, L | 1 |
| Solé, A | 1 |
| Guerra, D | 1 |
| Ugena, B | 1 |
| Haddox, VG | 1 |
| Weissman, S | 1 |
| Wallace, D | 1 |
| Hiner, D | 1 |
| Droppa, DC | 1 |
| Khantzian, EJ | 1 |
| Goldstein, A | 1 |
| Berger, H | 1 |
| Seljan, BJ | 1 |
| Fisch, A | 1 |
| Patch, VD | 1 |
| Greenfield, A | 1 |
| Raynes, AE | 1 |
| McKenna, G | 1 |
| Levine, M | 1 |
| Jackman, JM | 1 |
| Howe, LP | 1 |
| Whitehead, CC | 1 |
| Bralove, R | 1 |
| Kelly, N | 1 |
| Renteria, R | 1 |
| Stein, A | 1 |
| Blake, DA | 1 |
| Distasio, C | 1 |
| Robbins, PR | 1 |
| Levine, DG | 1 |
| Levin, DB | 1 |
| Sloan, IH | 1 |
| Chappel, JN | 1 |
| Van Sloten, M | 1 |
| Kinohi, RG | 1 |
| Irwin, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acceptability/Feasibility Testing of an Intervention Targeting Intolerance of Uncertainty[NCT05172427] | 45 participants (Anticipated) | Interventional | 2021-09-15 | Recruiting | |||
| An Open-Label Pilot Study of Desvenlafaxine for Opioid-Dependent Patients With Comorbid Depression[NCT02200406] | Phase 4 | 18 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Behavioral Intervention to Improve Insomnia Symptoms in Patients With Opioid Use Disorder[NCT05588726] | 0 participants (Actual) | Interventional | 2022-01-01 | Withdrawn (stopped due to Staff no longer available to continue enrollment and other research activities) | |||
| Exploring the Utility and Safety of Benzodiazepine Prescribing Among People Receiving Opiate Replacement Therapy in Scotland (the BENZORT Study).[NCT04622995] | 46,899 participants (Actual) | Observational | 2021-08-01 | Completed | |||
| Maternal Opioid Treatment: Human Experimental Research[NCT00271219] | Phase 3 | 175 participants (Actual) | Interventional | 2005-07-31 | Completed | ||
| MOms in REcovery (MORE): Defining Optimal Care for Pregnant Women and Infants[NCT04251208] | 444 participants (Actual) | Observational | 2019-07-30 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00271219)
Timeframe: birth
| Intervention | cm (Mean) |
|---|---|
| A Methadone | 33.0 |
| B Buprenorphine | 33.8 |
(NCT00271219)
Timeframe: delivery until hospital discharge (min=2 days, max=79 days)
| Intervention | days (Mean) |
|---|---|
| A Methadone | 17.5 |
| B Buprenorphine | 10.0 |
NAS was measured with the MOTHER NAS scale, which includes 28 items, 19 of which are used for scoring and medication decisions. Scores can range from 0 to 42, with higher scores indicating more severe withdrawal. (NCT00271219)
Timeframe: minimum twice daily from birth until NAS no longer measured (min=10 days)
| Intervention | Score on the scale (Mean) |
|---|---|
| A Methadone | 12.8 |
| B Buprenorphine | 11.0 |
(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | percentage of HIV risk behaviors (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
Pregnant women maintained on an opioid agonist medication may require upward adjustment to their medication during the course of pregnant. The Dose Adequacy Measure represented a recordation of dosing adjustments during the course of the study. (NCT00271219)
Timeframe: from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | dose increase per trimester (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
The Addiction Severity Index is a structured clinical interview that assesses problem severity in 7 areas of functioning: alcohol use, drug use, medical, legal, employment, psychosocial, and psychiatric status. Each area of functioning yields a composite scale score between 0 and 1, with higher scores indicating greater problem severity in that area. Only the psychosocial index was examined in this study. (NCT00271219)
Timeframe: at delivery
| Intervention | Score on the scale (Mean) |
|---|---|
| Methadone | .014 |
| Buprenorphine | .088 |
(NCT00271219)
Timeframe: monthly from study entry until discontinuation or delivery (min=29 days, max=239 days)
| Intervention | percentage of drug use (Number) |
|---|---|
| A Methadone | NA |
| B Buprenorphine | NA |
Neonatal abstinence syndrome (NAS) characterized by hyperirritability of the central nervous system and dysfunction in the autonomic nervous system, gastrointestinal tract, and respiratory system.11 When left untreated, NAS can result in serious illness (e.g., diarrhea, feeding difficulties, weight loss, and seizures) and death. (NCT00271219)
Timeframe: From birth until hospital discharge (min=4 days, max=10, depending on site)
| Intervention | participants (Number) |
|---|---|
| A Methadone | 41 |
| B Buprenorphine | 27 |
Total amount in mg (NCT00271219)
Timeframe: Start of NAS treatment until discontinuation of NAS treatment (min=0 days, max=76 days)
| Intervention | mg (Mean) |
|---|---|
| A Methadone | 10.4 |
| B Buprenorphine | 1.1 |
3 reviews available for methadone and Anxiety
| Article | Year |
|---|---|
Spirituality, religiosity, depression, anxiety, and drug-use consequences during methadone maintenance therapy.
Topics: Anxiety; Depression; Evidence-Based Nursing; Humans; Methadone; Spirituality; Substance-Related Diso | 2013 |
Behavioral treatment of drug addiction: a review and analysis.
Topics: Adolescent; Adult; Anxiety; Aversive Therapy; Behavior Therapy; Conditioning, Classical; Conditionin | 1973 |
Opiate addiction: a critique of theory and some implications for treatment.
Topics: Aggression; Anger; Anxiety; Conditioning, Psychological; Depression; Euphoria; Humans; Methadone; Mo | 1974 |
14 trials available for methadone and Anxiety
| Article | Year |
|---|---|
The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial.
Topics: Adult; Anxiety; Depression; Folic Acid; Humans; Male; Methadone; Middle Aged; Vitamins | 2023 |
A pilot, open-label, 8-week study evaluating desvenlafaxine for treatment of major depression in methadone-maintained individuals with opioid use disorder.
Topics: Adult; Antidepressive Agents; Anxiety; Craving; Depressive Disorder, Major; Desvenlafaxine Succinate | 2018 |
The effects of melatonin supplementation on mental health, metabolic and genetic profiles in patients under methadone maintenance treatment.
Topics: Adult; Analgesics, Opioid; Antioxidants; Anxiety; Blood Glucose; C-Reactive Protein; Cholesterol, HD | 2019 |
Transcranial Direct Current Stimulation on Opium Craving, Depression, and Anxiety: A Preliminary Study.
Topics: Adolescent; Adult; Anxiety; Combined Modality Therapy; Craving; Depression; Humans; Male; Methadone; | 2019 |
The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial.
Topics: Adult; Anxiety; Carotenoids; Depression; Double-Blind Method; Drug Therapy, Combination; Humans; Met | 2019 |
The effect of Olanzapine and Sertraline on personality disorder in patients with methadone maintenance therapy.
Topics: Adult; Aggression; Analgesics, Opioid; Anxiety; Benzodiazepines; Borderline Personality Disorder; De | 2010 |
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind | 2012 |
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind | 2012 |
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind | 2012 |
Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes.
Topics: Adolescent; Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Depression; Double-Blind | 2012 |
PET imaging of dopamine transporter and drug craving during methadone maintenance treatment and after prolonged abstinence in heroin users.
Topics: Adult; Anxiety; Caudate Nucleus; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Hero | 2008 |
Methadone dose decreases and anxiety reduction.
Topics: Adult; Anxiety; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Male; Methadone; Opioi | 1984 |
A protocol to switch high-dose, methadone-maintained subjects to buprenorphine.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Buprenorphine; Clonidine; Cocaine; Drug Administration Schedule | 1997 |
An evaluation of breathing nervous regulation of opiate dependent patients during in 6 months' methadone maintenance treatment programme.
Topics: Adult; Anxiety; Female; Humans; Lung; Male; Methadone; Middle Aged; Opioid-Related Disorders; Respir | 2001 |
Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients.
Topics: Adrenergic alpha-Antagonists; Adult; Analgesics, Opioid; Anxiety; Blood Pressure; Double-Blind Metho | 2002 |
Depression and anxiety in heroin addicts: a placebo-controlled study of doxepin in combination with methadone.
Topics: Administration, Oral; Adult; Alcoholic Intoxication; Amphetamine; Anxiety; Barbiturates; Capsules; C | 1975 |
Psychiatric indications for clonidine: the neuropharmacologic and clinical basis.
Topics: Animals; Anxiety; Bipolar Disorder; Clinical Trials as Topic; Clonidine; Double-Blind Method; Drug T | 1986 |
58 other studies available for methadone and Anxiety
| Article | Year |
|---|---|
Impact of combination of intermittent theta burst stimulation and methadone maintenance treatment in individuals with opioid use disorder: A comparative study.
Topics: Anxiety; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Transcranial Ma | 2023 |
Multi-level predictors of psychological problems among methadone maintenance treatment patients in difference types of settings in Vietnam.
Topics: Adult; Anxiety; Comorbidity; Cross-Sectional Studies; Depression; Humans; Male; Methadone; Middle Ag | 2019 |
Prevalence and correlates of suicide attempt among Chinese individuals receiving methadone maintenance treatment for heroin dependence.
Topics: Adult; Antisocial Personality Disorder; Anxiety; China; Depressive Disorder, Major; Female; Heroin; | 2019 |
Long-time effects of prenatal morphine, tramadol, methadone, and buprenorphine exposure on seizure and anxiety in immature rats.
Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Buprenorphine; Female; Locomotion; Male; Maze | 2020 |
Challenges of methadone maintenance treatment during the COVID-19 epidemic in China: Policy and service recommendations.
Topics: Ambulatory Care; Analgesics, Opioid; Anxiety; China; Coronavirus Infections; COVID-19; Delivery of H | 2020 |
Effects of treatment status and life quality on anxiety in MMT patients.
Topics: Anxiety; China; Depression; Humans; Methadone; Opiate Substitution Treatment; Quality of Life | 2021 |
Benzodiazepine Use in Opioid Maintenance Treatment Programme: Risks and Clinical Outcomes.
Topics: Adult; Analgesics, Opioid; Anxiety; Benzodiazepines; Buprenorphine; Cross-Sectional Studies; Diazepa | 2021 |
Intolerance of uncertainty in opioid dependency - Relationship with trait anxiety and impulsivity.
Topics: Adult; Analgesics, Opioid; Anxiety; Case-Control Studies; Decision Making; Female; Heroin; Humans; I | 2017 |
Traditional Chinese medicine-facilitated treatments may relieve anxiety symptoms during drug switching from methadone to buprenorphine/naloxone for treating opioid dependence.
Topics: Anxiety; Buprenorphine, Naloxone Drug Combination; Drug Substitution; Drugs, Chinese Herbal; Humans; | 2017 |
Treadmill exercise attenuates the severity of physical dependence, anxiety, depressive-like behavior and voluntary morphine consumption in morphine withdrawn rats receiving methadone maintenance treatment.
Topics: Animals; Anxiety; Depression; Exercise Test; Male; Maze Learning; Methadone; Morphine; Morphine Depe | 2018 |
Non-suicidal self-injury in Chinese heroin-dependent patients receiving methadone maintenance treatment: Prevalence and associated factors.
Topics: Adult; Anxiety; China; Cross-Sectional Studies; Depression; Female; Heroin Dependence; Humans; Lonel | 2018 |
Insomnia and excessive daytime sleepiness in women and men receiving methadone and buprenorphine maintenance treatment.
Topics: Adult; Analgesics, Opioid; Anxiety; Buprenorphine; Comorbidity; Cross-Sectional Studies; Depression; | 2019 |
Specificity of personality relationships to particular forms of concurrent substance use among methadone maintenance therapy clients.
Topics: Adult; Anxiety; Arousal; Comorbidity; Correlation of Data; Female; Hope; Humans; Male; Methadone; Mi | 2019 |
Maternal stress and behavioral adaptation in methadone- or buprenorphine-exposed toddlers.
Topics: Adult; Anxiety; Buprenorphine; Child; Child, Preschool; Depression; Family; Female; Humans; Longitud | 2013 |
Factors associated with depression and anxiety among patients attending community-based methadone maintenance treatment in China.
Topics: Adult; Analgesics, Opioid; Anxiety; China; Comorbidity; Cross-Sectional Studies; Depression; Drug Us | 2015 |
Familial expressed emotion among heroin addicts in methadone maintenance treatment: does it matter?
Topics: Adult; Anxiety; Depression; Expressed Emotion; Family; Female; Heroin Dependence; Humans; Male; Medi | 2015 |
Associations between chronic non-cancer pain and medication assisted treatment outcomes for opiate addiction.
Topics: Adult; Anxiety; Chronic Pain; Comorbidity; Depression; Female; Humans; Kentucky; Male; Methadone; Op | 2015 |
[Association between negative emotion and interpersonal sensitivity among patients in methadone maintenance treatment].
Topics: Adult; Anxiety; Depression; Female; Humans; Interpersonal Relations; Male; Methadone; Middle Aged; O | 2015 |
Changes in psychological well-being among heroin-dependent adolescents during psychologically supported opiate substitution treatment.
Topics: Adolescent; Adolescent Behavior; Anger; Anxiety; Buprenorphine; Combined Modality Therapy; Depressio | 2018 |
[Characteristics of subjects under opiate maintenance treatment in primary care using the OPEMA data 2013].
Topics: Adolescent; Adult; Alcohol Drinking; Anxiety; Benzodiazepines; Buprenorphine; Depressive Disorder; D | 2016 |
Resilience associated with mental health problems among methadone maintenance treatment patients in Guangzhou, China.
Topics: Adult; Anxiety; China; Depression; Female; Humans; Male; Mental Health; Methadone; Middle Aged; Opia | 2017 |
[Study on anxiety and depression status among the methadone maintenance treatment patients in Wuxi, Jiangsu].
Topics: Anxiety; China; Depression; Female; Heroin Dependence; Humans; Male; Methadone | 2008 |
An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey.
Topics: Adolescent; Adult; Aggression; Aging; Alcohol Drinking; Amphetamine-Related Disorders; Anxiety; Atte | 2008 |
Exploring the relationship between perceived inter-dose opioid withdrawal and patient characteristics in methadone maintenance treatment.
Topics: Adult; Affect; Anxiety; Behavior, Addictive; Female; Humans; Male; Methadone; Opioid-Related Disorde | 2009 |
Benzodiazepine use and misuse among patients in a methadone program.
Topics: Anxiety; Baltimore; Benzodiazepines; Female; Health Surveys; Humans; Male; Methadone; Middle Aged; O | 2011 |
Subsequent anxiety-related behavior in rats exposed to low-dose methadone during gestation, lactation or both periods consecutively.
Topics: Animals; Anxiety; Behavior, Animal; Dose-Response Relationship, Drug; Female; Growth; Lactation; Met | 2012 |
Do we undervalue feelings in patients who are cognitively impaired?
Topics: Aggression; Alzheimer Disease; Analgesics, Opioid; Anger; Anxiety; Brain Injuries; Cognition; Cognit | 2006 |
Psychometric evaluation of the Dutch version of the Subjective Opiate Withdrawal Scale (SOWS).
Topics: Adult; Anxiety; Body Temperature; Body Temperature Regulation; Facial Expression; Heroin Dependence; | 2007 |
Self-medication hypothesis of substance use: testing Khantzian's updated theory.
Topics: Adult; Affect; Affective Symptoms; Anxiety; Behavior, Addictive; Depression; Female; Hostility; Huma | 2007 |
Oral premedication with methadone, promethazine and diclofenac.
Topics: Administration, Oral; Anxiety; Diclofenac; Female; Humans; Male; Methadone; Pain, Postoperative; Pre | 1993 |
The physiological interrelationships between depression, drugs, and sexuality.
Topics: Antihypertensive Agents; Anxiety; Cannabis; Contraceptives, Oral; Depression; Ethanol; Female; Genit | 1978 |
The abstinence phobia.
Topics: Adaptation, Psychological; Anxiety; Heroin; Heroin Dependence; Humans; Methadone; Phobic Disorders; | 1979 |
Biofeedback application to drug addiction in the University of Colorado drug rehabilitation program.
Topics: Anxiety; Biofeedback, Psychology; Colorado; Costs and Cost Analysis; Electromyography; Heroin Depend | 1978 |
Rapid opiate detoxification: clinical evidence of antidepressant and antipanic effects of opiates.
Topics: Adult; Anxiety; Clonidine; Depression; Drug Therapy, Combination; Fear; Humans; Imipramine; Male; Me | 1979 |
Differences in heroin addicts seeking inpatient detoxification, ambulatory detoxification, or methadone maintenance.
Topics: Adult; Ambulatory Care; Anxiety; Community Mental Health Services; Female; Heroin Dependence; Humans | 1979 |
Treatment of methadone withdrawal with cerebral electrotherapy (electrosleep).
Topics: Adolescent; Adult; Anxiety; Electronarcosis; Evaluation Studies as Topic; Heroin Dependence; Humans; | 1979 |
Psychotropic drugs in opioid addicts on methadone treatment.
Topics: Adult; Anxiety; Depression; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Male; Meth | 1976 |
Psychopathology, craving, and mood during heroin acquisition: an experimental study.
Topics: Adult; Aggression; Anxiety; Depression; Drive; Emotions; Heroin; Heroin Dependence; Hostility; Human | 1976 |
Effect of neurotone therapy during methadone detoxification.
Topics: Adult; Anxiety; Electric Stimulation Therapy; Female; Heroin Dependence; Humans; Male; Methadone; Mi | 1976 |
Doxepin: a useful adjunct in the treatment of heroin addicts in a methadone program.
Topics: Adult; Aged; Anxiety; California; Doxepin; Female; Heroin Dependence; Humans; Male; Methadone; Middl | 1976 |
The role of drugs in the treatment of opioid addicts.
Topics: Alcoholism; Anxiety; Clonidine; Dextropropoxyphene; Heroin; Humans; Inactivation, Metabolic; Kinetic | 1986 |
Considerations on the psychotherapy of the substance abuser.
Topics: Adult; Alcoholics Anonymous; Alcoholism; Anxiety; Cocaine; Female; Humans; Male; Methadone; Middle A | 1986 |
Efficacy of clonidine and of methadone in the rapid detoxification of patients dependent on heroin.
Topics: Adolescent; Adult; Analysis of Variance; Anxiety; Blood Pressure; Clonidine; Double-Blind Method; Dr | 1985 |
Psychological adjustment--mood and personality fluctuations of long-term methadone maintenance patients.
Topics: Adult; Anxiety; Counseling; Depression; Evaluation Studies as Topic; Female; Hawaii; Heroin; Hostili | 1972 |
The significance of diagnosis in the treatment of narcotics addicts.
Topics: Adult; Anxiety; Community Health Services; Depression; Evaluation Studies as Topic; Heroin; Humans; | 1970 |
Some descriptive measures on 100 consecutive VA hospital drug abuse admissions.
Topics: Adolescent; Adult; Amphetamine; Antisocial Personality Disorder; Anxiety; Barbiturates; Depression; | 1974 |
Heroin addiction and the role of methadone in its treatment.
Topics: Animals; Anxiety; Compulsive Behavior; Conditioning, Classical; Conditioning, Operant; Dogs; Drug To | 1972 |
Methadone maintenance programs.
Topics: Anxiety; Crime; Heroin; Heroin Dependence; Humans; Legislation as Topic; Methadone; Motivation; Subs | 1973 |
The transfer of administration and operation of an ongoing methadone maintenance program.
Topics: Anxiety; Attitude of Health Personnel; California; Community Mental Health Services; Heroin Dependen | 1973 |
Internal indicators for the management and prognosis of patients in a methadone maintenance program (internal states self-report scale).
Topics: Adult; Anxiety; Depression; Female; Heroin Dependence; Humans; Male; Methadone; Personality Assessme | 1973 |
A hypothesis concerning the difficulty of withdrawal from maintenance on methadone.
Topics: Anxiety; California; Community Health Services; Female; Heroin Dependence; Humans; Male; Methadone; | 1973 |
Methadone and mortality: toward a sociology of addiction.
Topics: Anxiety; Heroin Dependence; Humans; Methadone; Morals; Sociology | 1973 |
Methadone pseudowithdrawal: etiological considerations.
Topics: Anxiety; Depression; Diagnosis, Differential; Heroin Dependence; Humans; Methadone; Substance Withdr | 1973 |
The effect of a change in milieu on patient progress in methadone maintainance.
Topics: Anxiety; Environment; Frustration; Heroin Dependence; Humans; Methadone; Milieu Therapy; New York Ci | 1973 |
A comparison of level of anxiety, depression and hostility with methadone plasma concentration in opioid-dependent patients receiving methadone on a maintenance dosage schedule.
Topics: Anxiety; Community Health Services; Depression; Female; Heroin Dependence; Hostility; Humans; Male; | 1973 |
Methadone dose and emotional states in drug-addicted patients.
Topics: Adult; Affective Symptoms; Anxiety; Depression; Dose-Response Relationship, Drug; Heroin Dependence; | 1974 |
Personality correlates of success in a methadone maintenance program.
Topics: Adult; Anxiety; Black or African American; Community Health Services; Cooperative Behavior; Counseli | 1972 |
Drug effects on the foot shock-induced behavior of paired mice.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Electroshock; Foot; Hostility; Humans; Hy | 1968 |