Page last updated: 2024-10-30

methadone and Anesthesia

methadone has been researched along with Anesthesia in 58 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

ExcerptRelevanceReference
" We compared the hemodynamic effects of an IV bolus of methadone 20 mg with those of fentanyl 10 microg/kg for the induction of anesthesia in combination with etomidate 0."9.11Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate. ( Bowdle, TA; Even, A; Shen, DD; Swardstrom, M, 2004)
"The aim of this study was to evaluate the effect of a single dose of methadone administered at anesthesia induction on postoperative analgesic requirements in ASA I-III patients after moderate-to-severely painful surgery scheduled for ≥90 minutes."5.30A preoperative single dose of methadone for moderate-to-severely painful surgery reduces postoperative morphine consumption. ( Aguirre, J; Bastian, K; Buehler, PK; Hollinger, A; Lecheler, L; Rüst, CA; Siegemund, M; Slizyte, D; Studer, W; Toft, K, 2019)
" We compared the hemodynamic effects of an IV bolus of methadone 20 mg with those of fentanyl 10 microg/kg for the induction of anesthesia in combination with etomidate 0."5.11Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate. ( Bowdle, TA; Even, A; Shen, DD; Swardstrom, M, 2004)
" During general anesthesia lasting about six hours with methohexital or propofol, naloxone was administered with doubling of the dose every 15 minutes with a starting bolus dose of 0."5.08Alternative strategies of opiate detoxification: evaluation of the so-called ultra-rapid detoxification. ( Gastpar, M; Kaube, H; Kienbaum, P; Klein, S; Peters, J; Scherbaum, N, 1998)
"Methadone was injected with the dogs in sternal recumbency; the observer was unaware of the administration route."2.72A comparison of extradural and intravenous methadone on intraoperative isoflurane and postoperative analgesia requirements in dogs. ( Jones, RS; Leibetseder, EN; Mosing, M, 2006)
"Objective and subjective withdrawal symptoms were measured until urine was free of drugs and patients had no withdrawal symptoms."2.69Opiate detoxification under anesthesia: no apparent benefit but suppression of thyroid hormones and risk of pulmonary and renal failure. ( Hirtl, C; Pfab, R; Zilker, T, 1999)
"Opioid misuse is common, as is opioid agonist treatment of opioid dependence."1.72Opioid use disorder in anaesthesia and intensive care: Prevention, diagnosis and management. ( Demirkol, A; Murnion, BP, 2022)
" Equally important perioperative treatment principles are stabilization of physical dependence by substitution with methadone (for heroin addicts) or benzodiazepines/clonidine (for alcohol, sedatives and hypnotics addiction), avoidance of stress and craving, thorough intraoperative and postoperative stress relief by using regional techniques or systematically higher than normal dosages of anesthetics and opioids, strict avoidance of inadequate dosage of analgetics, postoperative optimization of regional or systemic analgesia by non-opioids and coanalgetics and consideration of the complex physical and psychological characteristics and comorbidities."1.33[Anesthesia and analgesia in addicts: basis for establishing a standard operating procedure]. ( Heid, F; Jage, J, 2006)

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-199035 (60.34)18.7374
1990's3 (5.17)18.2507
2000's7 (12.07)29.6817
2010's9 (15.52)24.3611
2020's4 (6.90)2.80

Authors

AuthorsStudies
Murnion, BP1
Demirkol, A1
Giannettoni, G1
Moretti, G1
Menchetti, L1
Pepe, A1
Bellocchi, F1
Bufalari, A2
Nannarone, S1
Kerr, CL1
Swanton, WE1
De Souza, E1
Anderson, TA1
Chan, FJ1
Schwartz, AM1
Wong, J1
Chen, C1
Tiwari, B1
Kim, SJ1
Singhal, R1
Notrica, DM1
Jones, JS1
Maher, DP1
Walia, D1
Heller, NM1
Gozalo-Marcilla, M1
Luna, SP1
Gasthuys, F1
Pollaris, E1
Vlaminck, L1
Martens, A1
Haspeslagh, M1
Schauvliege, S1
Romagnoli, N1
Barbarossa, A1
Cunto, M1
Ballotta, G1
Zambelli, D1
Armorini, S1
Zaghini, A1
Lambertini, C1
Bastian, K1
Buehler, PK1
Slizyte, D1
Rüst, CA1
Toft, K1
Studer, W1
Lecheler, L1
Aguirre, J1
Siegemund, M1
Hollinger, A1
De Monte, V1
Staffieri, F1
Di Meo, A1
Vannucci, J1
Bert, B1
Hartje, I1
Voigt, JP1
Arndt, G1
Ulbrich, HF1
Fink, H1
Hauff, P1
LUND, CJ2
REUTNER, TF1
GRUHZIT, OM1
EVERETT, FG1
THORP, RH1
WALTON, E1
OFNER, P1
KIRCHHOF, AC2
DAVID, NA2
WOODS, LA1
WYNGAARDEN, JB1
SEEVERS, MH1
Bryson, EO1
Van Vynckt, D1
Samoy, Y1
Polis, I1
Bosmans, T1
Verschooten, F1
Van Ryssen, B1
Scherbaum, N2
Kienbaum, P2
HALL, HC1
PRATT, JH1
WELCH, JS1
MASSON, AH1
MILOSEVIC, MP1
SZIRMAI, E1
COLEMAN, DJ1
LEVIN, J1
JONES, PO2
HADICKE, M1
KUNTZE, M1
COLEMEN, DJ1
HARGROVE, RL1
BUCHEL, L1
LEVY, J1
TANGUY, O1
JOHNSTON, CM1
LAMOUREUX, L2
SHOONER, F2
TREMBLAY, L2
KOERNER, M1
NEAL, MJ1
ROBSON, JM1
PESCE, A1
RUGIERO, G1
BERIC, B1
HORAKOVA, Z1
VOTAVA, Z1
LENTZ, W1
EICHLER, J1
PAULSON, JA1
LUNDY, JS1
Freye, E1
Levy, JV1
Partecke, L1
Bowdle, TA1
Even, A1
Shen, DD1
Swardstrom, M1
CRONHEIM, G1
EHRLICH, M1
Digiusto, E1
Lintzeris, N1
Breen, C1
Kimber, J1
Mattick, RP1
Bell, J1
Ali, R1
Saunders, JB1
Leibetseder, EN1
Mosing, M1
Jones, RS1
Jage, J1
Heid, F1
Wangler, MA1
Rosenblatt, RM1
Wiedemann, K1
Bauer, PK1
Schütze, U1
Hanf, K1
Parsons, LE1
Walmsley, JP1
Mannesmann, G1
Müller, B1
Carpentier, M1
Klein, S1
Kaube, H1
Peters, J1
Gastpar, M1
Pfab, R1
Hirtl, C1
Zilker, T1
Wood, M1
Chariot, J1
Appia, F1
Vaille, C1
Rozé, C1
Logara-Kalantzis, A1
Baettig, P1
Bucher, K1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Methadone on Perioperative Analgesia After Posterior Lumbar Fusion - A Randomized, Placebo-controlled, Double-blinded Study[NCT01125059]0 participants (Actual)Interventional2010-05-31Withdrawn (stopped due to Unable to fulfill recruitment)
The Effect of Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery: A Randomized, Double-Blinded Controlled Trial[NCT02747875]26 participants (Actual)Interventional2016-09-30Terminated (stopped due to Drug Shortage)
The Influence of Pharmacogenetics on Methadone Dose, Safety, and Outcomes After Spine Fusion[NCT01677650]Phase 10 participants (Actual)Interventional2014-03-31Withdrawn (stopped due to Investigator moved to new institution)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Total Opioid Dose, in Morphine Equivalents, in the First 24 Hours After Pediatric Cardiac Bypass Surgery.

The distribution of the total opioid dose in the first 24 hours will be evaluated by randomization group (methadone vs. fentanyl) and differences between groups will be tested. It is hypothesized that compared to fentanyl, methadone administered intraoperative will result in a significantly lower total opioid dose (morphine or oxycodone) during the first 24 hour postoperative period. Assuming no difference between the two treatment strategies in the population, a total sample size of 52 in each group will provide 80% power to detect an effect size of 0.1. Significance will be measured as a 30% reduction in postoperative pain requirement. (NCT02747875)
Timeframe: 24 hours

Interventionmg postop morphine equivelant 24hr (Mean)
Control - Fentanyl0.55
Treatment - Methadone0.48

Opioid-related Adverse Events Including: Respiratory Failure, Cardiovascular Instability, and Postoperative Nausea and Vomiting

Opioid-related adverse events will be monitored closely and a secondary analysis will compare the incidence of side effects between the two groups during the first 24-hour postoperative period. The Pearson's contingency chi-square test will be used to evaluate any differences between the randomization groups in opioid-related adverse events during the first 24-hour postoperative period. (NCT02747875)
Timeframe: 24 hours

,
Interventionevents (Mean)
Ondansetron DosesEmesis EpisodesHypoventilation EpisodesArrhythmias
Control - Fentanyl3.812.7200
Treatment - Methadone3.432.0800

Reviews

4 reviews available for methadone and Anesthesia

ArticleYear
Anesthesia update - Incorporating methadone into companion animal anesthesia and analgesic protocols: A narrative review.
    The Canadian veterinary journal = La revue veterinaire canadienne, 2023, Volume: 64, Issue:11

    Topics: Analgesics, Opioid; Anesthesia; Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Methadone; Pain; Pe

2023
The anesthetic implications of illicit opioid abuse.
    International anesthesiology clinics, 2011,Winter, Volume: 49, Issue:1

    Topics: Analgesics, Opioid; Anesthesia; Drug Overdose; Humans; Methadone; Opioid-Related Disorders

2011
[Ultrashort withdrawal from opiate dependence].
    Medizinische Monatsschrift fur Pharmazeuten, 2003, Volume: 26, Issue:8

    Topics: Anesthesia; Humans; Methadone; Narcotics; Opioid-Related Disorders; Substance Withdrawal Syndrome

2003
Plasma drug binding: implications for anesthesiologists.
    Anesthesia and analgesia, 1986, Volume: 65, Issue:7

    Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Ca

1986

Trials

9 trials available for methadone and Anesthesia

ArticleYear
Clinical applicability of detomidine and methadone constant rate infusions for surgery in standing horses.
    Veterinary anaesthesia and analgesia, 2019, Volume: 46, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Anesthesia; Anesthesia, Dental; Anesthetics, Combined; Animals

2019
Evaluation of methadone concentrations in bitches and in umbilical cords after epidural or systemic administration for caesarean section: A randomized trial.
    Veterinary anaesthesia and analgesia, 2019, Volume: 46, Issue:3

    Topics: Analgesics, Opioid; Anesthesia; Anesthesia, Epidural; Animals; Cesarean Section; Dogs; Female; Injec

2019
A preoperative single dose of methadone for moderate-to-severely painful surgery reduces postoperative morphine consumption.
    Minerva anestesiologica, 2019, Volume: 85, Issue:10

    Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia; Double-Blind Method; Female; Fe

2019
Comparison of ketamine-dexmedetomidine-methadone and tiletamine-zolazepam-methadone combinations for short-term anaesthesia in domestic pigs.
    Veterinary journal (London, England : 1997), 2015, Volume: 205, Issue:3

    Topics: Anesthesia; Anesthetics, Combined; Animals; Dexmedetomidine; Female; Ketamine; Male; Methadone; Moni

2015
Use of gabapentin for attenuation of symptoms following rapid opiate detoxification (ROD)--correlation with neurophysiological parameters--.
    Neurophysiologie clinique = Clinical neurophysiology, 2004, Volume: 34, Issue:2

    Topics: Acetates; Adult; Amines; Anesthesia; Anesthetics, Intravenous; Cyclohexanecarboxylic Acids; Electric

2004
Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Anesthesia; Blood Pressure; Double-Blind Method; Female; Fentanyl

2004
Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Anesthesia; Blood Pressure; Double-Blind Method; Female; Fentanyl

2004
Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Anesthesia; Blood Pressure; Double-Blind Method; Female; Fentanyl

2004
Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Anesthesia; Blood Pressure; Double-Blind Method; Female; Fentanyl

2004
Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Anesthesia; Blood Pressure; Double-Blind Method; Female; Fentanyl

2004
Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Anesthesia; Blood Pressure; Double-Blind Method; Female; Fentanyl

2004
Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Anesthesia; Blood Pressure; Double-Blind Method; Female; Fentanyl

2004
Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Anesthesia; Blood Pressure; Double-Blind Method; Female; Fentanyl

2004
Methadone for the induction of anesthesia: plasma histamine concentration, arterial blood pressure, and heart rate.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:6

    Topics: Adult; Aged; Analysis of Variance; Anesthesia; Blood Pressure; Double-Blind Method; Female; Fentanyl

2004
A comparison of extradural and intravenous methadone on intraoperative isoflurane and postoperative analgesia requirements in dogs.
    Veterinary anaesthesia and analgesia, 2006, Volume: 33, Issue:2

    Topics: Analgesics, Opioid; Anesthesia; Anesthetics, Inhalation; Animals; Dogs; Dose-Response Relationship,

2006
Alternative strategies of opiate detoxification: evaluation of the so-called ultra-rapid detoxification.
    Pharmacopsychiatry, 1998, Volume: 31, Issue:6

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Anesthesia; Clonidine; Female; Humans; Male; Methadone

1998
Opiate detoxification under anesthesia: no apparent benefit but suppression of thyroid hormones and risk of pulmonary and renal failure.
    Journal of toxicology. Clinical toxicology, 1999, Volume: 37, Issue:1

    Topics: Acute Kidney Injury; Adult; Anesthesia; Codeine; Female; Heroin Dependence; Humans; Male; Methadone;

1999

Other Studies

45 other studies available for methadone and Anesthesia

ArticleYear
Opioid use disorder in anaesthesia and intensive care: Prevention, diagnosis and management.
    Anaesthesia and intensive care, 2022, Volume: 50, Issue:1-2

    Topics: Analgesics, Opioid; Anesthesia; Australia; Buprenorphine; Critical Care; Drug Tolerance; Humans; Met

2022
Sedation quality of alfaxalone associated with butorphanol, methadone or pethidine in cats injected into the supraspinatus or the quadriceps muscle.
    Journal of feline medicine and surgery, 2022, Volume: 24, Issue:8

    Topics: Anesthesia; Animals; Butorphanol; Cat Diseases; Cats; Hypnotics and Sedatives; Injections, Intramusc

2022
Pediatric Perioperative Methadone Dosing Trial: An Illustration of the Challenges in Conducting High-Quality Pediatric Anesthesia Research.
    Anesthesia and analgesia, 2021, 08-01, Volume: 133, Issue:2

    Topics: Analgesics, Opioid; Anesthesia; Child; Humans; Methadone

2021
Use of Chronic Methadone Before Total Knee Arthroplasty.
    The Journal of arthroplasty, 2017, Volume: 32, Issue:7

    Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia; Arthroplasty, Replacemen

2017
Reply to Letter to the Editor.
    Journal of pediatric surgery, 2018, Volume: 53, Issue:5

    Topics: Analgesia, Epidural; Anesthesia; Anesthetics; Child; Humans; Methadone; Pain Management; Retrospecti

2018
Suppression of Human Natural Killer Cells by Different Classes of Opioids.
    Anesthesia and analgesia, 2019, Volume: 128, Issue:5

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics

2019
Repeated anaesthesia with isoflurane and xylazine/levomethadone/fenpipramide premedication in female Beagle dogs: influence on general health and wellbeing.
    Laboratory animals, 2008, Volume: 42, Issue:4

    Topics: Anesthesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Animal Welfare; Animals; Animals, L

2008
Newer obstetric analgesics; preliminary evaluation of compounds No. 10720 and No. 10820 (dolophine).
    American journal of obstetrics and gynecology, 1948, Volume: 55, Issue:6

    Topics: Analgesia; Analgesics; Anesthesia; Anesthesiology; Female; Humans; Methadone; Obstetrics; Pregnancy

1948
Methadon, a new analgesic; study in combination with thiobarbiturate anesthesia in dogs.
    Journal of the American Veterinary Medical Association, 1948, Volume: 113, Issue:860

    Topics: Analgesics; Anesthesia; Animals; Dogs; Methadone; Thiobarbiturates

1948
The local anesthetic properties of amidone (dolophine).
    Anesthesiology, 1948, Volume: 9, Issue:2

    Topics: Anesthesia; Anesthesia, Local; Anesthesiology; Anesthetics, Local; Methadone

1948
Analgesic activity in compounds related to amidone.
    Nature, 1947, May-17, Volume: 159, Issue:4046

    Topics: Analgesics; Anesthesia; Anesthesiology; Methadone

1947
Clinical trial of a new synthetic heptanone analgesic (dolophine); preliminary report.
    Western journal of surgery, obstetrics, and gynecology, 1947, Volume: 55, Issue:3

    Topics: Analgesics; Anesthesia; Anesthesiology; Humans; Ketones; Methadone

1947
Newer obstetric analgesics; compounds No. 10720 and No. 10820, dolophine.
    Bulletin of the University of Minnesota Hospitals and Minnesota Medical Foundation. University of Minnesota. Hospitals, 1947, Apr-18, Volume: 18, Issue:23

    Topics: Analgesics; Anesthesia; Anesthesia, Obstetrical; Anesthesiology; Female; Gynecology; Methadone; Obst

1947
The addiction potentialities of 1,1,-(dimethylaminoisopropyl)-butanone-2 (amidone) in the monkey.
    Federation proceedings, 1947, Volume: 6, Issue:1

    Topics: Anesthesia; Anesthesiology; Animals; Barbital; Butanones; Haplorhini; Methadone

1947
Evaluation of two sedation protocols for use before diagnostic intra-articular anaesthesia in lame dogs.
    The Journal of small animal practice, 2011, Volume: 52, Issue:12

    Topics: Acepromazine; Anesthesia; Animals; Conscious Sedation; Dog Diseases; Dogs; Female; Hypnotics and Sed

2011
Methadone, scopolamine, and nembutal anesthesia in 15 dogs.
    Journal of the American Veterinary Medical Association, 1953, Volume: 122, Issue:913

    Topics: Anesthesia; Anesthesia, Intravenous; Animals; Barbiturates; Dogs; Methadone; Pentobarbital; Scopolam

1953
Hyatrobal and methadone hydrochloride in preoperative preparation of patients.
    Journal of the American Medical Association, 1955, Jan-15, Volume: 157, Issue:3

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Barbiturates; Humans; Methadone; Pain Man

1955
A trial of a new synthetic analgesic.
    Anaesthesia, 1956, Volume: 11, Issue:1

    Topics: Analgesia; Analgesics; Anesthesia; Anesthesia and Analgesia; Methadone; Nitrous Oxide; Pain Manageme

1956
Effect of adrenaline on the analgesic response of mice to morphine and related drugs.
    Archives internationales de pharmacodynamie et de therapie, 1955, Nov-01, Volume: 104, Issue:1

    Topics: Analgesia; Analgesics; Anesthesia; Anesthesia and Analgesia; Animals; Epinephrine; Meperidine; Metha

1955
[Coagulation effect of methadon during labor; comparative biological, biochemical and biophysical studies].
    Therapie der Gegenwart, 1956, Volume: 95, Issue:3

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Female; Humans; Labor, Obstetric; Methadone; Pain M

1956
Dipipanone hydrochloride as an adjunct to anaesthesia in obstetrics and surgery.
    British medical journal, 1957, May-11, Volume: 1, Issue:5027

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Female; Humans; Labor, Obstetric; Methadone; Obstet

1957
[Action of various synthetic analgesics in comparison with morphine & its derivatives].
    Pharmazeutische Zentralhalle fur Deutschland, 1957, Volume: 96, Issue:4

    Topics: Analgesia; Analgesics; Anesthesia; Anesthesia and Analgesia; Ephedrine; Meperidine; Methadone; Morph

1957
Controlled respiration by central depression.
    Anaesthesia, 1958, Volume: 13, Issue:1

    Topics: Anesthesia; Anesthesiology; Depression; Humans; Methadone; Respiration, Artificial

1958
[Potentiation of the analgesic action of methadon by 5-hydroxytryptamine (serotonin)].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences, 1958, May-19, Volume: 246, Issue:20

    Topics: Analgesia; Analgesics; Anesthesia; Anesthesia and Analgesia; Methadone; Serotonin; Serotonin Agents

1958
Dipipanone hydrochloride (pipadone) as a pre-delivery sedative and analgesic.
    Canadian Medical Association journal, 1958, Sep-15, Volume: 79, Issue:6

    Topics: Analgesia; Analgesics; Anesthesia; Anesthesia and Analgesia; Female; Humans; Hypnotics and Sedatives

1958
Preliminary clinical study of dipipanone hydrochloride (pipadone) in anaesthesia.
    Canadian Medical Association journal, 1959, Jun-15, Volume: 80, Issue:12

    Topics: Anesthesia; Anesthesiology; Humans; Liver Cirrhosis; Methadone

1959
[Preliminary clinical study of pipadone in anesthesia].
    L'union medicale du Canada, 1959, Volume: 88, Issue:7

    Topics: Anesthesia; Anesthesiology; Cardiovascular System; Humans; Methadone; Respiration

1959
[RE-ANESTHESIA].
    Der Anaesthesist, 1964, Volume: 13

    Topics: Adjuvants, Anesthesia; Anesthesia; Anesthesia, General; Anesthesiology; Atropa belladonna; Atropine;

1964
THE ANALGESIC PROPERTIES OF SUB-ANAESTHETIC DOSES OF ANAESTHETICS IN THE MOUSE.
    British journal of pharmacology and chemotherapy, 1964, Volume: 22

    Topics: Analgesia; Analgesics; Anesthesia; Anesthesia, Inhalation; Anesthetics; Animals; Cyclopropanes; Elec

1964
[CONTROLLABLE APNEA IN ANESTHESIA BY MEANS OF CENTRAL DEPRESSION DUE TO ANALGESICS].
    Gazzetta internazionale di medicina e chirurgia, 1964, Nov-30, Volume: 68

    Topics: Analgesics; Anesthesia; Apnea; Central Nervous System Agents; Depression; Dextromoramide; Humans; Me

1964
[Painless labor with polamidone S..].
    Medicinski glasnik, 1954, Volume: 8, Issue:9

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Female; Humans; Labor, Obstetric; Methadone; Pain M

1954
[Analgetic effect of morphine, dolsin and mecodin in various ways of application; a pharmacological study].
    Ceskoslovenska farmacie, 1955, Volume: 4, Issue:3

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Meperidine; Methadone; Morphine; Pain; Pain Managem

1955
[Premedication in pediatric anesthesia with Polamidon "C"].
    Bruns' Beitrage zur klinischen Chirurgie, 1961, Volume: 203

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesiology; Child; Humans; Methadone; Pediatric

1961
Anesthesia.
    Annual review of medicine, 1950, Volume: 1

    Topics: Anesthesia; Bis-Trimethylammonium Compounds; Blood Transfusion; Curare; Gallamine Triethiodide; Huma

1950
The combined use of pentobarbital sodium and methadone hydrochloride for anesthesia in dogs.
    Journal of the American Veterinary Medical Association, 1950, Volume: 116, Issue:880

    Topics: Anesthesia; Animals; Dogs; Methadone; Pentobarbital

1950
Short-term outcomes of five heroin detoxification methods in the Australian NEPOD Project.
    Addictive behaviors, 2005, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Ambulatory Care; Analgesics, Opioid; Anesthesia; Buprenorphine; Female; Heroin De

2005
[Anesthesia and analgesia in addicts: basis for establishing a standard operating procedure].
    Der Anaesthesist, 2006, Volume: 55, Issue:6

    Topics: Analgesics; Analgesics, Opioid; Anesthesia; Diagnosis, Dual (Psychiatry); Drug Tolerance; Humans; Hy

2006
Clinical experience with methadon.
    Anesthesiology, 1948, Volume: 9, Issue:6

    Topics: Anesthesia; Anesthesiology; Methadone

1948
Methadone titration to avoid excessive respiratory depression.
    Anesthesiology, 1983, Volume: 59, Issue:4

    Topics: Anesthesia; Humans; Methadone; Respiration

1983
[Influence of pancuronium bromide on spontaneous intestinal motility in the dog (author's transl)].
    Der Anaesthesist, 1982, Volume: 31, Issue:1

    Topics: Anesthesia; Animals; Colon; Dogs; Female; Gastrointestinal Motility; Ileum; Methadone; Muscle, Smoot

1982
Field use of an acetylpromazine/methadone/ketamine combination for anaesthesia in the horse and donkey.
    The Veterinary record, 1982, Oct-23, Volume: 111, Issue:17

    Topics: Acepromazine; Anesthesia; Animals; Horses; Ketamine; Methadone; Perissodactyla

1982
Measurement of cardiac output by the thermodilution method in rats: the effect of different volumes and temperatures of the indicator solution on cardiac output measurements and on cardiodynamics and hemodynamics of the anesthetized rat.
    Journal of pharmacological methods, 1980, Volume: 4, Issue:1

    Topics: Anesthesia; Animals; Cardiac Catheterization; Cardiac Output; Heart Rate; Hemodynamics; Indicators a

1980
[Pain, anesthesia and drug addiction].
    Revue de stomatologie et de chirurgie maxillo-faciale, 1997, Volume: 98, Issue:2

    Topics: Anesthesia; Comprehensive Health Care; Heroin; Heroin Dependence; Humans; Methadone; Morphine; Narco

1997
Etorphine inhibition of pancreatic exocrine secretion in rats: comparison with methadone.
    European journal of pharmacology, 1986, Feb-11, Volume: 121, Issue:1

    Topics: Anesthesia; Animals; Deoxyglucose; Diprenorphine; Electric Stimulation; Etorphine; Male; Methadone;

1986
Inspiratory versus expiratory efforts in pigeons: a search for selective drug influence.
    Agents and actions, 1973, Volume: 3, Issue:4

    Topics: Anesthesia; Animals; Atropine; Barbiturates; Benzoates; Chloralose; Chlorpromazine; Codeine; Columbi

1973