Page last updated: 2024-10-30

methadone and Amphetamine Abuse

methadone has been researched along with Amphetamine Abuse in 31 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Research Excerpts

ExcerptRelevanceReference
" In a double-blind, randomly stratified clinical trial investigating whether add-on dextromethorphan (60-120 mg/day) attenuated inflammation and the combined use of opioids in heroin-dependent patients undergoing methadone maintenance treatment, we evaluated whether inflammation is related to the progression of opioid dependence."9.16Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment. ( Chang, YH; Chen, PS; Chen, SH; Chen, SL; Chu, CH; Hong, JS; Lee, IH; Lee, SY; Lu, RB; Tao, PL; Yang, YK; Yeh, TL, 2012)
" In a double-blind, randomly stratified clinical trial investigating whether add-on dextromethorphan (60-120 mg/day) attenuated inflammation and the combined use of opioids in heroin-dependent patients undergoing methadone maintenance treatment, we evaluated whether inflammation is related to the progression of opioid dependence."5.16Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment. ( Chang, YH; Chen, PS; Chen, SH; Chen, SL; Chu, CH; Hong, JS; Lee, IH; Lee, SY; Lu, RB; Tao, PL; Yang, YK; Yeh, TL, 2012)
" They were assessed using the amphetamine abuse questionnaire (AAQ), addiction severity index (ASI) and Barratt impulsiveness scale (BIS)."4.02The Abuse Characteristics of Amphetamine-Type Stimulants in Patients Receiving Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment. ( Li, L; Liu, N; Liu, Y; Shen, W; Xu, L; Zhou, W, 2021)
"Available evidence indicated that methamphetamine dependence increased from 3."2.58Methamphetamine dependence in methadone treatment services in Iran: the first literature review of a new health concern. ( Alammehrjerdi, Z; Dolan, K; Ezard, N, 2018)
"To test if polysubstance use profiles and drug-related outcomes differ between those receiving and not receiving opioid substitution therapies (OST) among people who inject drugs (PWID)."1.43Differences in polysubstance use patterns and drug-related outcomes between people who inject drugs receiving and not receiving opioid substitution therapies. ( Alati, R; Betts, KS; Burns, L; Chan, G; Dietze, P; McIlwraith, F; Whittaker, E, 2016)
"Methadone maintenance treatment (MMT) was introduced to China in 2004 to reduce the harm of injecting drug users (IDUs)."1.42Illicit Heroin and Methamphetamine Use among Methadone Maintenance Treatment Patients in Dehong Prefecture of Yunnan Province, China. ( Bai, H; Ding, Y; Duan, S; Gao, M; He, N; Tang, R; Wang, J; Wang, R; Yang, Y; Ye, R, 2015)
"Recent clinical studies suggest that substance use may be associated with an acceleration of the ageing process, possibly related to a deficit of stem cell number or function."1.35An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey. ( Reece, AS, 2008)
"In a cohort of 501 drug abusers admitted to treatment in the period 1981-1991, mortality has been calculated as incidence rates."1.34Fatal overdoses and deaths by other causes in a cohort of Norwegian drug abusers--a competing risk approach. ( Amundsen, EJ; Kielland, KB; Ødegård, E, 2007)
"Methadone adherence was calculated as the fraction of days methadone was administered."1.34The impact of ongoing illicit drug use on methadone adherence in illicit drug users receiving treatment for HIV in a directly observed therapy program. ( Conway, B; DeVlaming, S; Duncan, F; Grebely, J; Khara, M; McLean, M; Mead, A; Petkau, AJ; Raffa, JD; Tossonian, H; Viljoen, M; Wong, T, 2007)
"Although it is said that drug addiction is associated with poor dental health, there is little research in this area."1.34Dentition of addiction in Queensland: poor dental status and major contributing drugs. ( Reece, AS, 2007)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (38.71)29.6817
2010's15 (48.39)24.3611
2020's4 (12.90)2.80

Authors

AuthorsStudies
Giang, LM1
Trang, NT1
Diep, NB1
Thuy, DTD1
Thuy, DT1
Hoe, HD1
Van, HTH1
Truc, TT1
Nguyen, HH1
Lai, NL1
Linh, PTD1
Vi, VTT1
Reback, CJ1
Leibowitz, A1
Li, L2
Lin, C1
Li, M1
Shoptaw, S1
Ordak, M2
Nasierowski, T2
Muszynska, E2
Bujalska-Zadrozny, M2
Rabiey, A1
Hassani-Abharian, P1
Farhad, M1
Moravveji, AR1
Akasheh, G1
Banafshe, HR2
Pawlik, K1
Liu, Y1
Liu, N1
Shen, W1
Zhou, W1
Xu, L1
Ahmadi, J1
Razeghian Jahromi, L1
Liu, CC1
Fang, CP1
Liu, TH1
Kuo, HW1
Liu, SC1
Wang, SC1
Chen, ACH1
Liu, YL1
Alammehrjerdi, Z1
Ezard, N1
Dolan, K1
Javdan, NS1
Ghoreishi, FS1
Sehat, M1
Ghaderi, A1
Zhang, L1
Bao, J1
Harrington, A1
Fan, X1
Ning, Z1
Zhang, J1
Shi, D1
Hu, M1
Zhou, Z1
Cai, Z1
Zhao, M1
Du, J1
Shariatirad, S1
Maarefvand, M1
Ekhtiari, H1
Wang, R1
Ding, Y1
Bai, H1
Duan, S1
Ye, R1
Yang, Y1
Wang, J1
Tang, R1
Gao, M1
He, N1
Dahlman, D1
Håkansson, A1
Björkman, P1
Blomé, MA1
Kral, AH1
Betts, KS1
Chan, G1
McIlwraith, F1
Dietze, P1
Whittaker, E1
Burns, L1
Alati, R1
Eksborg, S1
Rajs, J1
Reece, AS2
Suntharasamai, P1
Martin, M1
Vanichseni, S1
van Griensven, F1
Mock, PA1
Pitisuttithum, P1
Tappero, JW1
Sangkum, U1
Kitayaporn, D1
Gurwith, M1
Choopanya, K1
Stitzer, ML2
Petry, NM2
Peirce, J1
van Holst, RJ1
Schilt, T1
Yeh, TL2
Chen, KC1
Lin, SH1
Lee, IH2
Chen, PS2
Yao, WJ1
Lee, SY2
Yang, YK2
Lu, RB2
Liao, MH1
Chiu, NT1
Musshoff, F1
Madea, B1
Chen, SL1
Tao, PL1
Chang, YH1
Chen, SH1
Chu, CH1
Hong, JS1
Mulder, R1
Kolodner, KB1
Li, R1
Peirce, JM1
Roll, JM1
Hamilton, JA1
Grella, CE1
Hser, YI1
Huang, YC1
Stoové, M1
Ødegård, E1
Amundsen, EJ1
Kielland, KB1
Inciardi, JA1
Surratt, HL1
Kurtz, SP1
Cicero, TJ1
Raffa, JD1
Grebely, J1
Tossonian, H1
Wong, T1
Viljoen, M1
Khara, M1
Mead, A1
McLean, M1
Duncan, F1
Petkau, AJ1
DeVlaming, S1
Conway, B1
Miller, CL1
Strathdee, SA1
Li, K1
Kerr, T1
Wood, E1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics[NCT04706624]640 participants (Anticipated)Interventional2020-11-02Active, not recruiting
A Phase III Trial to Determine the Efficacy of AIDSVAX B/E Vaccine in Intravenous Drug Users in Bangkok, Thailand[NCT00006327]Phase 32,500 participants Interventional1999-03-31Completed
Pomegranate Juice Consumption by Patients Under Medication for Addiction Treatment as a Regulator of Craving and Blood Redox Status: The Study Protocol of a Randomized Control Trial (the NUTRIDOPE Study)[NCT05861544]58 participants (Anticipated)Interventional2023-03-23Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for methadone and Amphetamine Abuse

ArticleYear
Methamphetamine dependence in methadone treatment services in Iran: the first literature review of a new health concern.
    Asian journal of psychiatry, 2018, Volume: 31

    Topics: Adult; Amphetamine-Related Disorders; Central Nervous System Stimulants; Female; Humans; Iran; Male;

2018
Drug-related decrease in neuropsychological functions of abstinent drug users.
    Current drug abuse reviews, 2011, Volume: 4, Issue:1

    Topics: Alcoholism; Amphetamine-Related Disorders; Cannabis; Central Nervous System Stimulants; Cocaine; Coc

2011

Trials

6 trials available for methadone and Amphetamine Abuse

ArticleYear
An adaptive design to screen, treat, and retain people with opioid use disorders who use methamphetamine in methadone clinics (STAR-OM): study protocol of a clinical trial.
    Trials, 2022, Apr-23, Volume: 23, Issue:1

    Topics: Adolescent; Amphetamine-Related Disorders; COVID-19; HIV Infections; Humans; Methadone; Methamphetam

2022
Atomoxetine Efficacy in Methamphetamine Dependence during Methadone Maintenance Therapy.
    Archives of Iranian medicine, 2019, 12-01, Volume: 22, Issue:12

    Topics: Adrenergic Uptake Inhibitors; Adult; Amphetamine-Related Disorders; Analgesics, Opioid; Atomoxetine

2019
Comparing the effect of buprenorphine and methadone in the reduction of methamphetamine craving: a randomized clinical trial.
    Trials, 2017, 06-06, Volume: 18, Issue:1

    Topics: Adult; Amphetamine-Related Disorders; Analgesics, Opioid; Behavior, Addictive; Buprenorphine; Centra

2017
Factors associated with incarceration and incident human immunodeficiency virus (HIV) infection among injection drug users participating in an HIV vaccine trial in Bangkok, Thailand, 1999-2003.
    Addiction (Abingdon, England), 2009, Volume: 104, Issue:2

    Topics: Adult; AIDS Vaccines; Amphetamine-Related Disorders; Double-Blind Method; Female; HIV; HIV Infection

2009
Dextromethorphan attenuated inflammation and combined opioid use in humans undergoing methadone maintenance treatment.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2012, Volume: 7, Issue:4

    Topics: Adult; Amphetamine; Amphetamine-Related Disorders; Analgesics, Opioid; Central Nervous System Stimul

2012
Prize-based contingency management does not increase gambling.
    Drug and alcohol dependence, 2006, Jul-27, Volume: 83, Issue:3

    Topics: Adult; Alcoholism; Ambulatory Care; Amphetamine-Related Disorders; Central Nervous System Stimulants

2006

Other Studies

23 other studies available for methadone and Amphetamine Abuse

ArticleYear
Optimisation of methadone treatment in a group of patients on a mephedrone binge and dependent on many psychoactive substances.
    International journal of psychiatry in clinical practice, 2020, Volume: 24, Issue:1

    Topics: Adult; Amphetamine-Related Disorders; Central Nervous System Stimulants; Drug Therapy, Combination;

2020
Effectiveness of the methadone programme in the treatment of patients on a mephedrone binge and dependent on heroin: a retrospective study, 2010-19.
    International journal of psychiatry in clinical practice, 2020, Volume: 24, Issue:3

    Topics: Adult; Amphetamine-Related Disorders; Comorbidity; Cross-Sectional Studies; Female; Hepatitis C; Her

2020
The Abuse Characteristics of Amphetamine-Type Stimulants in Patients Receiving Methadone Maintenance Treatment and Buprenorphine Maintenance Treatment.
    Drug design, development and therapy, 2021, Volume: 15

    Topics: Adult; Amphetamine; Amphetamine-Related Disorders; Buprenorphine; Female; Humans; Male; Methadone; R

2021
APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment.
    Progress in neuro-psychopharmacology & biological psychiatry, 2018, 04-20, Volume: 83

    Topics: Adaptor Proteins, Signal Transducing; Adult; Amphetamine-Related Disorders; Amyloid beta-Peptides; B

2018
Mental health and cognitive function responses to quetiapine in patients with methamphetamine abuse under methadone maintenance treatment.
    Journal of affective disorders, 2019, 05-15, Volume: 251

    Topics: Adolescent; Adult; Aged; Amphetamine-Related Disorders; Antidepressive Agents; Cognition; Depression

2019
Mixed methods to explore factors associated with the decline of patients in the methadone maintenance treatment program in Shanghai, China.
    Harm reduction journal, 2019, 05-27, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Aged; Amphetamine-Related Disorders; Analgesics, Opioid; China; Female; Focus Gro

2019
Methamphetamine use and methadone maintenance treatment: an emerging problem in the drug addiction treatment network in Iran.
    The International journal on drug policy, 2013, Volume: 24, Issue:6

    Topics: Amphetamine-Related Disorders; Analgesics, Opioid; Behavior, Addictive; Central Nervous System Stimu

2013
Illicit Heroin and Methamphetamine Use among Methadone Maintenance Treatment Patients in Dehong Prefecture of Yunnan Province, China.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Adolescent; Adult; Aged; Amphetamine-Related Disorders; Analgesics, Opioid; China; Cross-Sectional S

2015
Correlates of Skin and Soft Tissue Infections in Injection Drug Users in a Syringe-Exchange Program in Malmö, Sweden.
    Substance use & misuse, 2015, Volume: 50, Issue:12

    Topics: Adult; Amphetamine-Related Disorders; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug

2015
Differences in polysubstance use patterns and drug-related outcomes between people who inject drugs receiving and not receiving opioid substitution therapies.
    Addiction (Abingdon, England), 2016, Volume: 111, Issue:7

    Topics: Abscess; Adolescent; Adult; Alcoholism; Amphetamine-Related Disorders; Analgesics, Opioid; Australia

2016
Causes and manners of death among users of heroin, methadone, amphetamine, and cannabis in relation to postmortem chemical tests for illegal drugs.
    Substance use & misuse, 2008, Volume: 43, Issue:10

    Topics: Adolescent; Adult; Aged; Amphetamine; Amphetamine-Related Disorders; Cause of Death; Diagnosis; Fema

2008
An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey.
    British dental journal, 2008, Dec-13, Volume: 205, Issue:11

    Topics: Adolescent; Adult; Aggression; Aging; Alcohol Drinking; Amphetamine-Related Disorders; Anxiety; Atte

2008
Motivational incentives research in the National Drug Abuse Treatment Clinical Trials Network.
    Journal of substance abuse treatment, 2010, Volume: 38 Suppl 1

    Topics: Adult; Amphetamine-Related Disorders; Cocaine-Related Disorders; Counseling; Female; Follow-Up Studi

2010
Availability of dopamine and serotonin transporters in opioid-dependent users--a two-isotope SPECT study.
    Psychopharmacology, 2012, Volume: 220, Issue:1

    Topics: Adult; Amphetamine-Related Disorders; Case-Control Studies; Corpus Striatum; Cross-Sectional Studies

2012
Driving under the influence of amphetamine-like drugs.
    Journal of forensic sciences, 2012, Volume: 57, Issue:2

    Topics: Adult; Amphetamine-Related Disorders; Amphetamines; Automobile Driving; Benzodiazepines; Cannabinoid

2012
Is it time for treatment trials in addiction?
    The New Zealand medical journal, 2004, Mar-12, Volume: 117, Issue:1190

    Topics: Alcohol Drinking; Amphetamine-Related Disorders; Crime; Data Collection; Humans; Methadone; New Zeal

2004
Mothers in substance abuse treatment: differences in characteristics based on involvement with child welfare services.
    Child abuse & neglect, 2006, Volume: 30, Issue:1

    Topics: Adolescent; Adult; Alcoholism; Ambulatory Care; Amphetamine-Related Disorders; California; Child; Ch

2006
Mortality in a cohort of opiate and amphetamine users in Perth, Western australia: Comment on Bartu et al. (2006).
    Addiction (Abingdon, England), 2006, Volume: 101, Issue:10

    Topics: Amphetamine-Related Disorders; Follow-Up Studies; Humans; Methadone; Narcotics; Opioid-Related Disor

2006
Fatal overdoses and deaths by other causes in a cohort of Norwegian drug abusers--a competing risk approach.
    Drug and alcohol dependence, 2007, Jul-10, Volume: 89, Issue:2-3

    Topics: Adult; Age Factors; Amphetamine-Related Disorders; Buprenorphine; Cause of Death; Cohort Studies; Co

2007
Mechanisms of prescription drug diversion among drug-involved club- and street-based populations.
    Pain medicine (Malden, Mass.), 2007, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Analgesics, Opioid; Antiretroviral Therapy, Highly

2007
The impact of ongoing illicit drug use on methadone adherence in illicit drug users receiving treatment for HIV in a directly observed therapy program.
    Drug and alcohol dependence, 2007, Jul-10, Volume: 89, Issue:2-3

    Topics: Amphetamine-Related Disorders; Antiretroviral Therapy, Highly Active; Benzodiazepines; Cocaine-Relat

2007
A longitudinal investigation into excess risk for blood-borne infection among young injection drug users (IUDs).
    The American journal of drug and alcohol abuse, 2007, Volume: 33, Issue:4

    Topics: Adult; Age Factors; Amphetamine-Related Disorders; British Columbia; Cocaine-Related Disorders; Comm

2007
Dentition of addiction in Queensland: poor dental status and major contributing drugs.
    Australian dental journal, 2007, Volume: 52, Issue:2

    Topics: Adult; Age Factors; Alcohol-Related Disorders; Amphetamine-Related Disorders; Cross-Sectional Studie

2007