methadone and Aging
methadone has been researched along with Aging in 37 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "People on methadone treatment have increased their life expectancy, aging prematurely with comorbidities." | 7.91 | [Aging in a methadone maintenance program. A perspective from the framework of social determinants of health]. ( Gutiérrez-Cáceres, S; Pedraz-Marcos, A; Serrano-Gallardo, P, 2019) |
| "People on methadone treatment have increased their life expectancy, aging prematurely with comorbidities." | 3.91 | [Aging in a methadone maintenance program. A perspective from the framework of social determinants of health]. ( Gutiérrez-Cáceres, S; Pedraz-Marcos, A; Serrano-Gallardo, P, 2019) |
| "The data for this analysis were derived from a qualitative study of the needs of aging methadone clients." | 3.75 | Mistrust and self-isolation: barriers to social support for older adult methadone clients. ( Rosen, D; Smith, ML, 2009) |
| "The lack of methadone pharmacokinetic data in children and neonates restrains dosing to achieve the target concentration in these populations." | 1.40 | The pharmacokinetics of methadone and its metabolites in neonates, infants, and children. ( Anderson, BJ; Drover, DR; Hammer, GB; Kern, S; Lugo, RA; Satterfield, K; Stemland, CJ; Tristani-Firouzi, M; Ward, RM, 2014) |
| "To compare the use of co-medication, the potential drug-drug interactions (PDDIs) and the effect on antiretroviral therapy (ART) tolerability and efficacy in HIV-infected individuals according to age, ≥ 50 years or <50 years." | 1.37 | Ageing with HIV: medication use and risk for potential drug-drug interactions. ( Back, D; Battegay, M; Bernasconi, E; Calmy, A; Cavassini, M; Elzi, L; Furrer, H; Khoo, S; Marzolini, C; Vernazza, P; Weber, R, 2011) |
| "Recent clinical studies suggest that substance use may be associated with an acceleration of the ageing process, possibly related to a deficit of stem cell number or function." | 1.35 | An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey. ( Reece, AS, 2008) |
| "Methadone was acquired by the perinatal guinea pig both transplacentally and via the milk, more agent being obtained by the former route." | 1.26 | Disposition of maternally-administered methadone and its effects on hepatic drug-metabolizing functions in perinatal guinea pigs. ( Ecobichon, DJ; Pak, RC, 1982) |
| "Methadone-exposed rats were found to be generally less active than controls at 21 days of age and more active than saline-treated pups at the 45 and 60 day test periods." | 1.26 | Development of motor activity in young rats following perinatal methadone exposure. ( McLaughlin, PJ; Thompson, CI; Zagon, IS, 1979) |
| "Methadone was administered daily to pregnant or nursing rats, or directly to neonates, and the effects on brain and heart weights and ornithine decarboxylase (ODC) activities were determined during postnatal development." | 1.26 | Effects of neonatal or maternal methadone administration on ornithine decarboxylase activity in brain and heart of developing rats. ( Bartolomé, M; Lau, C; Slotkin, TA, 1976) |
Research
Studies (37)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (59.46) | 18.7374 |
| 1990's | 1 (2.70) | 18.2507 |
| 2000's | 3 (8.11) | 29.6817 |
| 2010's | 11 (29.73) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Gutiérrez-Cáceres, S | 1 |
| Pedraz-Marcos, A | 1 |
| Serrano-Gallardo, P | 1 |
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
| He, C | 2 |
| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Zhang, X | 6 |
| Xu, N | 1 |
| Wang, R | 1 |
| Liu, S | 1 |
| He, H | 1 |
| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Zhang, C | 3 |
| Chen, L | 2 |
| Yang, X | 1 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
| Gao, K | 1 |
| Zager, RA | 1 |
| Johnson, ACM | 1 |
| Guillem, A | 1 |
| Keyser, J | 1 |
| Singh, B | 1 |
| Steubl, D | 1 |
| Schneider, MP | 1 |
| Meiselbach, H | 1 |
| Nadal, J | 1 |
| Schmid, MC | 1 |
| Saritas, T | 1 |
| Krane, V | 1 |
| Sommerer, C | 1 |
| Baid-Agrawal, S | 1 |
| Voelkl, J | 1 |
| Kotsis, F | 1 |
| Köttgen, A | 1 |
| Eckardt, KU | 1 |
| Scherberich, JE | 1 |
| Li, H | 4 |
| Yao, L | 2 |
| Sun, L | 3 |
| Zhu, Z | 1 |
| Naren, N | 1 |
| Zhang, XX | 2 |
| Gentile, GL | 1 |
| Rupert, AS | 1 |
| Carrasco, LI | 1 |
| Garcia, EM | 1 |
| Kumar, NG | 1 |
| Walsh, SW | 1 |
| Jefferson, KK | 1 |
| Guest, RL | 1 |
| Samé Guerra, D | 1 |
| Wissler, M | 1 |
| Grimm, J | 1 |
| Silhavy, TJ | 1 |
| Lee, JH | 2 |
| Yoo, JS | 1 |
| Kim, Y | 1 |
| Kim, JS | 2 |
| Lee, EJ | 1 |
| Roe, JH | 1 |
| Delorme, M | 1 |
| Bouchard, PA | 1 |
| Simon, M | 1 |
| Simard, S | 1 |
| Lellouche, F | 1 |
| D'Urzo, KA | 1 |
| Mok, F | 1 |
| D'Urzo, AD | 1 |
| Koneru, B | 1 |
| Lopez, G | 1 |
| Farooqi, A | 1 |
| Conkrite, KL | 1 |
| Nguyen, TH | 1 |
| Macha, SJ | 1 |
| Modi, A | 1 |
| Rokita, JL | 1 |
| Urias, E | 1 |
| Hindle, A | 1 |
| Davidson, H | 1 |
| Mccoy, K | 1 |
| Nance, J | 1 |
| Yazdani, V | 1 |
| Irwin, MS | 1 |
| Yang, S | 1 |
| Wheeler, DA | 1 |
| Maris, JM | 1 |
| Diskin, SJ | 1 |
| Reynolds, CP | 1 |
| Abhilash, L | 1 |
| Kalliyil, A | 1 |
| Sheeba, V | 1 |
| Hartley, AM | 2 |
| Meunier, B | 2 |
| Pinotsis, N | 1 |
| Maréchal, A | 2 |
| Xu, JY | 1 |
| Genko, N | 1 |
| Haraux, F | 1 |
| Rich, PR | 1 |
| Kamalanathan, M | 1 |
| Doyle, SM | 1 |
| Xu, C | 1 |
| Achberger, AM | 1 |
| Wade, TL | 1 |
| Schwehr, K | 1 |
| Santschi, PH | 1 |
| Sylvan, JB | 1 |
| Quigg, A | 1 |
| Leong, W | 1 |
| Xu, W | 2 |
| Gao, S | 1 |
| Zhai, X | 1 |
| Wang, C | 2 |
| Gilson, E | 1 |
| Ye, J | 1 |
| Lu, Y | 1 |
| Yan, R | 1 |
| Zhang, Y | 6 |
| Hu, Z | 1 |
| You, Q | 1 |
| Cai, Q | 1 |
| Yang, D | 1 |
| Gu, S | 1 |
| Dai, H | 1 |
| Zhao, X | 1 |
| Gui, C | 1 |
| Gui, J | 1 |
| Wu, PK | 1 |
| Hong, SK | 1 |
| Starenki, D | 1 |
| Oshima, K | 1 |
| Shao, H | 1 |
| Gestwicki, JE | 1 |
| Tsai, S | 1 |
| Park, JI | 1 |
| Wang, Y | 7 |
| Zhao, R | 1 |
| Gu, Z | 1 |
| Dong, C | 2 |
| Guo, G | 1 |
| Li, L | 4 |
| Barrett, HE | 1 |
| Meester, EJ | 1 |
| van Gaalen, K | 1 |
| van der Heiden, K | 1 |
| Krenning, BJ | 1 |
| Beekman, FJ | 1 |
| de Blois, E | 1 |
| de Swart, J | 1 |
| Verhagen, HJ | 1 |
| Maina, T | 1 |
| Nock, BA | 1 |
| Norenberg, JP | 1 |
| de Jong, M | 1 |
| Gijsen, FJH | 1 |
| Bernsen, MR | 1 |
| Martínez-Milla, J | 1 |
| Galán-Arriola, C | 1 |
| Carnero, M | 1 |
| Cobiella, J | 1 |
| Pérez-Camargo, D | 1 |
| Bautista-Hernández, V | 1 |
| Rigol, M | 1 |
| Solanes, N | 1 |
| Villena-Gutierrez, R | 1 |
| Lobo, M | 1 |
| Mateo, J | 1 |
| Vilchez-Tschischke, JP | 1 |
| Salinas, B | 1 |
| Cussó, L | 1 |
| López, GJ | 1 |
| Fuster, V | 1 |
| Desco, M | 1 |
| Sanchez-González, J | 1 |
| Ibanez, B | 1 |
| van den Berg, P | 1 |
| Schweitzer, DH | 1 |
| van Haard, PMM | 1 |
| Geusens, PP | 1 |
| van den Bergh, JP | 1 |
| Zhu, X | 1 |
| Huang, X | 2 |
| Xu, H | 2 |
| Yang, G | 2 |
| Lin, Z | 1 |
| Salem, HF | 1 |
| Nafady, MM | 1 |
| Kharshoum, RM | 1 |
| Abd El-Ghafar, OA | 1 |
| Farouk, HO | 1 |
| Domiciano, D | 1 |
| Nery, FC | 1 |
| de Carvalho, PA | 1 |
| Prudente, DO | 1 |
| de Souza, LB | 1 |
| Chalfun-Júnior, A | 1 |
| Paiva, R | 1 |
| Marchiori, PER | 1 |
| Lu, M | 2 |
| An, Z | 1 |
| Jiang, J | 2 |
| Li, J | 7 |
| Du, S | 1 |
| Zhou, H | 1 |
| Cui, J | 1 |
| Wu, W | 1 |
| Liu, Y | 7 |
| Song, J | 1 |
| Lian, Q | 1 |
| Uddin Ahmad, Z | 1 |
| Gang, DD | 1 |
| Konggidinata, MI | 1 |
| Gallo, AA | 1 |
| Zappi, ME | 1 |
| Yang, TWW | 1 |
| Johari, Y | 1 |
| Burton, PR | 1 |
| Earnest, A | 1 |
| Shaw, K | 1 |
| Hare, JL | 1 |
| Brown, WA | 1 |
| Kim, GA | 1 |
| Han, S | 1 |
| Choi, GH | 1 |
| Choi, J | 1 |
| Lim, YS | 1 |
| Gallo, A | 1 |
| Cancelli, C | 1 |
| Ceron, E | 1 |
| Covino, M | 1 |
| Capoluongo, E | 1 |
| Pocino, K | 1 |
| Ianiro, G | 1 |
| Cammarota, G | 1 |
| Gasbarrini, A | 1 |
| Montalto, M | 1 |
| Somasundar, Y | 1 |
| Lu, IC | 1 |
| Mills, MR | 1 |
| Qian, LY | 1 |
| Olivares, X | 1 |
| Ryabov, AD | 1 |
| Collins, TJ | 1 |
| Zhao, L | 1 |
| Doddipatla, S | 1 |
| Thomas, AM | 1 |
| Nikolayev, AA | 1 |
| Galimova, GR | 1 |
| Azyazov, VN | 1 |
| Mebel, AM | 1 |
| Kaiser, RI | 1 |
| Guo, S | 1 |
| Yang, P | 1 |
| Yu, X | 2 |
| Wu, Y | 2 |
| Zhang, H | 1 |
| Yu, B | 2 |
| Han, B | 1 |
| George, MW | 1 |
| Moor, MB | 1 |
| Bonny, O | 1 |
| Langenberg, E | 1 |
| Paik, H | 1 |
| Smith, EH | 1 |
| Nair, HP | 1 |
| Hanke, I | 1 |
| Ganschow, S | 1 |
| Catalan, G | 1 |
| Domingo, N | 1 |
| Schlom, DG | 1 |
| Assefa, MK | 1 |
| Wu, G | 2 |
| Hayton, TW | 1 |
| Becker, B | 1 |
| Enikeev, D | 1 |
| Netsch, C | 1 |
| Gross, AJ | 1 |
| Laukhtina, E | 1 |
| Glybochko, P | 1 |
| Rapoport, L | 1 |
| Herrmann, TRW | 1 |
| Taratkin, M | 1 |
| Dai, W | 1 |
| Shi, J | 2 |
| Carreno, J | 1 |
| Kloner, RA | 1 |
| Pickersgill, NA | 1 |
| Vetter, JM | 1 |
| Kim, EH | 1 |
| Cope, SJ | 1 |
| Du, K | 1 |
| Venkatesh, R | 1 |
| Giardina, JD | 1 |
| Saad, NES | 1 |
| Bhayani, SB | 1 |
| Figenshau, RS | 1 |
| Eriksson, J | 1 |
| Landfeldt, E | 1 |
| Ireland, S | 1 |
| Jackson, C | 1 |
| Wyatt, E | 1 |
| Gaudig, M | 1 |
| Stancill, JS | 1 |
| Happ, JT | 1 |
| Broniowska, KA | 1 |
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| Corbett, JA | 1 |
| Tang, LF | 1 |
| Bi, YL | 1 |
| Fan, Y | 2 |
| Sun, YB | 1 |
| Wang, AL | 1 |
| Xiao, BH | 1 |
| Wang, LF | 1 |
| Qiu, SW | 1 |
| Guo, SW | 1 |
| Wáng, YXJ | 1 |
| Sun, J | 2 |
| Chu, S | 1 |
| Pan, Q | 1 |
| Li, D | 2 |
| Zheng, S | 2 |
| Ma, L | 1 |
| Wang, L | 3 |
| Hu, T | 1 |
| Wang, F | 1 |
| Han, Z | 1 |
| Yin, Z | 1 |
| Ge, X | 1 |
| Xie, K | 1 |
| Lei, P | 1 |
| Dias-Santagata, D | 1 |
| Lennerz, JK | 1 |
| Sadow, PM | 1 |
| Frazier, RP | 1 |
| Govinda Raju, S | 1 |
| Henry, D | 1 |
| Chung, T | 1 |
| Kherani, J | 1 |
| Rothenberg, SM | 1 |
| Wirth, LJ | 1 |
| Marti, CN | 1 |
| Choi, NG | 1 |
| Bae, SJ | 1 |
| Ni, L | 1 |
| Luo, X | 1 |
| Dai, T | 1 |
| Yang, Y | 3 |
| Lee, R | 1 |
| Fleischer, AS | 1 |
| Wemhoff, AP | 1 |
| Ford, CR | 1 |
| Kleppinger, EL | 1 |
| Helms, K | 1 |
| Bush, AA | 1 |
| Luna-Abanto, J | 1 |
| García Ruiz, L | 1 |
| Laura Martinez, J | 1 |
| Álvarez Larraondo, M | 1 |
| Villoslada Terrones, V | 1 |
| Dukic, L | 1 |
| Maric, N | 1 |
| Simundic, AM | 1 |
| Chogtu, B | 1 |
| Ommurugan, B | 1 |
| Thomson, SR | 1 |
| Kalthur, SG | 1 |
| Benidir, M | 1 |
| El Massoudi, S | 1 |
| El Ghadraoui, L | 1 |
| Lazraq, A | 1 |
| Benjelloun, M | 1 |
| Errachidi, F | 1 |
| Cassar, M | 1 |
| Law, AD | 1 |
| Chow, ES | 1 |
| Giebultowicz, JM | 1 |
| Kretzschmar, D | 1 |
| Salonurmi, T | 1 |
| Nabil, H | 1 |
| Ronkainen, J | 1 |
| Hyötyläinen, T | 1 |
| Hautajärvi, H | 1 |
| Savolainen, MJ | 1 |
| Tolonen, A | 1 |
| Orešič, M | 1 |
| Känsäkoski, P | 1 |
| Rysä, J | 1 |
| Hakkola, J | 1 |
| Hukkanen, J | 1 |
| Zhu, N | 1 |
| Li, Y | 4 |
| Du, Q | 1 |
| Hao, P | 1 |
| Cao, X | 1 |
| Li, CX | 1 |
| Zhao, S | 1 |
| Luo, XM | 1 |
| Feng, JX | 1 |
| Gonzalez-Cotto, M | 1 |
| Guo, L | 1 |
| Karwan, M | 1 |
| Sen, SK | 1 |
| Barb, J | 1 |
| Collado, CJ | 1 |
| Elloumi, F | 1 |
| Palmieri, EM | 1 |
| Boelte, K | 1 |
| Kolodgie, FD | 1 |
| Finn, AV | 1 |
| Biesecker, LG | 1 |
| McVicar, DW | 1 |
| Qu, F | 1 |
| Deng, Z | 1 |
| Xie, Y | 2 |
| Tang, J | 3 |
| Chen, Z | 2 |
| Luo, W | 1 |
| Xiong, D | 1 |
| Zhao, D | 1 |
| Fang, J | 1 |
| Zhou, Z | 1 |
| Niu, PP | 1 |
| Song, B | 1 |
| Xu, YM | 1 |
| Zhang, Z | 2 |
| Qiu, N | 1 |
| Yin, J | 1 |
| Zhang, J | 3 |
| Guo, W | 1 |
| Liu, M | 2 |
| Liu, T | 2 |
| Chen, D | 5 |
| Luo, K | 1 |
| He, Z | 2 |
| Zheng, G | 1 |
| Xu, F | 1 |
| Sun, W | 1 |
| Yin, F | 1 |
| van Hest, JCM | 1 |
| Du, L | 2 |
| Shi, X | 1 |
| Kang, S | 1 |
| Duan, W | 1 |
| Zhang, S | 2 |
| Feng, J | 2 |
| Qi, N | 1 |
| Shen, G | 1 |
| Ren, H | 1 |
| Shang, Q | 1 |
| Zhao, W | 2 |
| Yang, Z | 2 |
| Jiang, X | 2 |
| Alame, M | 1 |
| Cornillot, E | 1 |
| Cacheux, V | 1 |
| Tosato, G | 1 |
| Four, M | 1 |
| De Oliveira, L | 1 |
| Gofflot, S | 1 |
| Delvenne, P | 1 |
| Turtoi, E | 1 |
| Cabello-Aguilar, S | 1 |
| Nishiyama, M | 1 |
| Turtoi, A | 1 |
| Costes-Martineau, V | 1 |
| Colinge, J | 1 |
| Guo, Q | 1 |
| Quan, M | 1 |
| Dong, J | 1 |
| Bai, J | 1 |
| Han, R | 1 |
| Cai, Y | 1 |
| Lv, YQ | 1 |
| Chen, Q | 1 |
| Lyu, HD | 1 |
| Deng, L | 1 |
| Zhou, D | 1 |
| Xiao, X | 1 |
| De Langhe, S | 1 |
| Billadeau, DD | 1 |
| Lou, Z | 1 |
| Zhang, JS | 1 |
| Xue, Z | 1 |
| Shen, XD | 1 |
| Gao, F | 1 |
| Busuttil, RW | 1 |
| Kupiec-Weglinski, JW | 1 |
| Ji, H | 1 |
| Otano, I | 1 |
| Alvarez, M | 1 |
| Minute, L | 1 |
| Ochoa, MC | 1 |
| Migueliz, I | 1 |
| Molina, C | 1 |
| Azpilikueta, A | 1 |
| de Andrea, CE | 1 |
| Etxeberria, I | 1 |
| Sanmamed, MF | 1 |
| Teijeira, Á | 1 |
| Berraondo, P | 1 |
| Melero, I | 1 |
| Zhong, Z | 1 |
| Xie, X | 1 |
| Yu, Q | 1 |
| Zhou, C | 1 |
| Liu, C | 2 |
| Liu, W | 1 |
| Chen, W | 1 |
| Yin, Y | 1 |
| Li, CW | 1 |
| Hsu, JL | 1 |
| Zhou, Q | 1 |
| Hu, B | 1 |
| Fu, P | 1 |
| Atyah, M | 1 |
| Ma, Q | 2 |
| Xu, Y | 1 |
| Dong, Q | 1 |
| Hung, MC | 1 |
| Ren, N | 1 |
| Huang, P | 1 |
| Liao, R | 1 |
| Chen, X | 3 |
| Cao, Q | 1 |
| Yuan, X | 1 |
| Nie, W | 1 |
| Yang, J | 2 |
| Shao, B | 1 |
| Ma, X | 1 |
| Bi, Z | 1 |
| Liang, X | 1 |
| Tie, Y | 1 |
| Mo, F | 1 |
| Xie, D | 1 |
| Wei, Y | 1 |
| Wei, X | 2 |
| Dokla, EME | 1 |
| Fang, CS | 1 |
| Chu, PC | 1 |
| Chang, CS | 1 |
| Abouzid, KAM | 1 |
| Chen, CS | 1 |
| Blaszczyk, R | 1 |
| Brzezinska, J | 1 |
| Dymek, B | 1 |
| Stanczak, PS | 1 |
| Mazurkiewicz, M | 1 |
| Olczak, J | 1 |
| Nowicka, J | 1 |
| Dzwonek, K | 1 |
| Zagozdzon, A | 1 |
| Golab, J | 1 |
| Golebiowski, A | 1 |
| Xin, Z | 1 |
| Himmelbauer, MK | 1 |
| Jones, JH | 1 |
| Enyedy, I | 1 |
| Gilfillan, R | 1 |
| Hesson, T | 1 |
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| Field, E | 1 |
Clinical Trials (5)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blind, Controlled, Multi-site Study of the Pharmacokinetics and Pharmacodynamics of Methadone vs. Morphine During Mechanical Ventilation Following Cardiac Surgery in Neonates, Infants and Children[NCT01094522] | Phase 1/Phase 2 | 47 participants (Actual) | Interventional | 2010-03-31 | Completed | ||
| Methadone for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery[NCT03778372] | 55 participants (Actual) | Observational | 2019-01-01 | Completed | |||
| Safety and Single Dose Population Pharmacokinetics and Bioavailability of Methadone and Its Enantiomers in Newborns and Young Infants At 29-48 Weeks Post Menstrual Age[NCT00715988] | Phase 1 | 7 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| The Effect of Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery: A Randomized, Double-Blinded Controlled Trial[NCT02747875] | 26 participants (Actual) | Interventional | 2016-09-30 | Terminated (stopped due to Drug Shortage) | |||
| Bictegravir in the Elderly Living With HIV: Impact of Polypharmacy and Multimorbidity (BICEP)[NCT05064020] | 162 participants (Anticipated) | Observational | 2020-08-01 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
•Amount of Study Drug Administered During the 24-hour Dosing Period
(NCT01094522)
Timeframe: 24 hours
| Intervention | mg (Mean) |
|---|---|
| Methadone | 8.56 |
| Morphine | 13.77 |
•Pain Scores (FLACC) During the 24 Hours Study Period
"Average of hourly FLACC score for each subject over 24 hours was calculated, followed by median and full range for total subjects in each arm.~FLACC (Face, Leg, Activity, Cry, Consolability) score ranges from 0-10 with 0 representing no pain" (NCT01094522)
Timeframe: 24 hours
| Intervention | units on a scale (Median) |
|---|---|
| Methadone | 1.375 |
| Morphine | 1.917 |
Maximum Concentration of Methadone Including Its Metabolites (EDDP and EMDP)
(NCT01094522)
Timeframe: 0, 15, 30 minutes, 1, 2, 4, 6 hrs, every 6 hrs up to 24 hrs
| Intervention | ng/mL (Median) | ||
|---|---|---|---|
| Methadone | EDDP | EMDP | |
| Methadone | 52.35 | 3.42 | 0.194 |
Maximum Concentration of Morphine Including Its Metabolites (Morphine-3-glucuronide and Morphine-6-glucuronide)
(NCT01094522)
Timeframe: 0, 15, 30 minutes, 1, 2, 4, 6 hrs, every 6 hrs up to 24 hrs
| Intervention | ng/mL (Median) | ||
|---|---|---|---|
| Morphine | M3G | M6G | |
| Morphine | 27.55 | 225 | 22.95 |
Total Opioid Dose, in Morphine Equivalents, in the First 24 Hours After Pediatric Cardiac Bypass Surgery.
The distribution of the total opioid dose in the first 24 hours will be evaluated by randomization group (methadone vs. fentanyl) and differences between groups will be tested. It is hypothesized that compared to fentanyl, methadone administered intraoperative will result in a significantly lower total opioid dose (morphine or oxycodone) during the first 24 hour postoperative period. Assuming no difference between the two treatment strategies in the population, a total sample size of 52 in each group will provide 80% power to detect an effect size of 0.1. Significance will be measured as a 30% reduction in postoperative pain requirement. (NCT02747875)
Timeframe: 24 hours
| Intervention | mg postop morphine equivelant 24hr (Mean) |
|---|---|
| Control - Fentanyl | 0.55 |
| Treatment - Methadone | 0.48 |
Opioid-related Adverse Events Including: Respiratory Failure, Cardiovascular Instability, and Postoperative Nausea and Vomiting
Opioid-related adverse events will be monitored closely and a secondary analysis will compare the incidence of side effects between the two groups during the first 24-hour postoperative period. The Pearson's contingency chi-square test will be used to evaluate any differences between the randomization groups in opioid-related adverse events during the first 24-hour postoperative period. (NCT02747875)
Timeframe: 24 hours
| Intervention | events (Mean) | |||
|---|---|---|---|---|
| Ondansetron Doses | Emesis Episodes | Hypoventilation Episodes | Arrhythmias | |
| Control - Fentanyl | 3.81 | 2.72 | 0 | 0 |
| Treatment - Methadone | 3.43 | 2.08 | 0 | 0 |
Reviews
2 reviews available for methadone and Aging
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone.
Topics: Absorption; Aging; Aspirin; Blood Proteins; Dose-Response Relationship, Drug; Drug Interactions; Fem | 1976 |
Trials
2 trials available for methadone and Aging
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Less impairment on one portion of a driving-relevant psychomotor battery in buprenorphine-maintained than in methadone-maintained patients: results of a randomized clinical trial.
Topics: Adult; Aging; Attention; Automobile Driving; Buprenorphine; Cognition; Female; Humans; Male; Memory, | 2005 |
Other Studies
34 other studies available for methadone and Aging
| Article | Year |
|---|---|
[Aging in a methadone maintenance program. A perspective from the framework of social determinants of health].
Topics: Adult; Age of Onset; Aging; Comorbidity; Female; Hepatitis C; HIV Infections; Humans; Life Expectanc | 2019 |
Methadone Maintenance Treatment for Older Adults: Cost and Logistical Considerations.
Topics: Aged; Aging; Analgesics, Opioid; Humans; Medicare; Methadone; Middle Aged; Opiate Substitution Treat | 2018 |
Inflammatory chemokine eotaxin-1 is correlated with age in heroin dependent patients under methadone maintenance therapy.
Topics: Adult; Aging; Amyloid beta-Peptides; Brain; Case-Control Studies; Chemokine CCL11; Cotinine; Female; | 2018 |
Ageing opioid users' increased risk of methadone-specific death in the UK.
Topics: Adolescent; Adult; Aging; Analgesics, Opioid; Databases, Factual; Female; Heroin; Humans; Male; Meth | 2018 |
An ageing methadone population: A challenge for treating doctors.
Topics: Aging; General Practice; Humans; Medication Reconciliation; Methadone; Opiate Substitution Treatment | 2019 |
Impact of opioid pharmacotherapy on arterial stiffness and vascular ageing: cross-sectional and longitudinal studies.
Topics: Adult; Aging; Blood Vessels; Buprenorphine; Cross-Sectional Studies; Endothelium, Vascular; Female; | 2013 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele | 2014 |
An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey.
Topics: Adolescent; Adult; Aggression; Aging; Alcohol Drinking; Amphetamine-Related Disorders; Anxiety; Atte | 2008 |
Mistrust and self-isolation: barriers to social support for older adult methadone clients.
Topics: Aging; Female; Humans; Interviews as Topic; Male; Methadone; Middle Aged; Midwestern United States; | 2009 |
Differing age related trajectories of dysfunction in several organ systems in opiate dependence.
Topics: Adult; Aged; Aging; Aging, Premature; Analgesics, Opioid; Disease Progression; Female; Hair Color; H | 2012 |
Ageing with HIV: medication use and risk for potential drug-drug interactions.
Topics: Adult; Aged; Aging; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cardiovascular Agents; C | 2011 |
Gender differences in physical and mental health outcomes among an aging cohort of individuals with a history of heroin dependence.
Topics: Adult; Aged; Aging; California; Female; Follow-Up Studies; Health Status; Heroin Dependence; Humans; | 2012 |
Delays in growth and biochemical development of rat brain caused by maternal methadone administration: are the alterations in synaptogenesis and cellular maturation independent of reduced maternal food intake?
Topics: Aging; Animals; Body Weight; Brain; Eating; Female; Methadone; Organ Size; Ornithine Decarboxylase; | 1982 |
Motoric and attentional behavior in infants of methadone-maintained women.
Topics: Aging; Attention; Behavior; Female; Humans; Infant; Male; Methadone; Motor Activity; Opioid-Related | 1983 |
Endocrine effects of methadone in rats; acute effects in adults.
Topics: Aging; Animals; Corticosterone; Dose-Response Relationship, Drug; Female; Growth Hormone; Hormones; | 1983 |
Methadone in brain and its effects on locomotor activity of young and aged mice.
Topics: Aging; Animals; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Male; Methadone; Mice | 1983 |
Age-dependent alterations in the accumulation of l-methadone in the brain synaptosomes and other subcellular fractions.
Topics: Aging; Animals; Brain; Methadone; Rats; Rats, Inbred Strains; Subcellular Fractions; Synaptosomes | 1984 |
Disposition of maternally-administered methadone and its effects on hepatic drug-metabolizing functions in perinatal guinea pigs.
Topics: Aging; Animals; Animals, Newborn; Blood Proteins; Female; Glucuronosyltransferase; Guinea Pigs; Live | 1982 |
Ontogeny of endocrine responses to methadone in rats.
Topics: Aging; Animals; Corticosterone; Growth Hormone; Kinetics; Methadone; Naloxone; Pituitary Hormones; P | 1983 |
Effect of prior narcotic addiction on response to treatment of alcoholism.
Topics: Adolescent; Adult; Aged; Aging; Alcoholism; Female; Heroin Dependence; Humans; Male; Marriage; Metha | 1980 |
Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.
Topics: Aging; Animals; Animals, Newborn; Female; Heart; Methadone; Myocardium; Ornithine Decarboxylase; Pol | 1982 |
Long-term thermoregulatory changes following perinatal methadone exposure in rats.
Topics: Aging; Animals; Body Temperature Regulation; Body Weight; Cold Temperature; Defecation; Eating; Hot | 1981 |
In contrast to cocaine, prenatal exposure to methadone does not produce detectable alterations in the developing mouse brain.
Topics: Aging; Animals; Animals, Newborn; Astrocytes; Brain; Cerebral Cortex; Cocaine; Cocaine-Related Disor | 1998 |
The aging addict: a longitudinal study of known abusers.
Topics: Adult; Age Factors; Aging; Ethnicity; Female; Heroin Dependence; History, 19th Century; History, 20t | 1978 |
Pharmacological effects and metabolic fate of levo-methadone during postnatal development in rat.
Topics: Aging; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Blood Proteins; Brain; Methadone; N | 1979 |
Development of motor activity in young rats following perinatal methadone exposure.
Topics: Aging; Animals; Behavior, Animal; Body Weight; Female; Male; Methadone; Motor Activity; Rats | 1979 |
Methadone exposure in utero: developmental status at one and two years of age.
Topics: Aging; Female; Growth; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intelligence Test | 1979 |
Effects of prenatal methadone on the rest-activity cycle of the pre-weanling rat.
Topics: Aging; Animals; Female; Methadone; Motor Activity; Pregnancy; Rats; Sleep; Time Factors | 1979 |
Behavioral effects of fetal and neonatal exposure to methadone in the rat.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Emotions; Female; Fetus; Growth; Male; Methadone; Pre | 1979 |
Responses of heart ornithine decarboxylase and adrenal catecholamines to methadone and sympathetic stimulants in developing and adults rats.
Topics: Adrenal Medulla; Aging; Animals; Animals, Newborn; Body Weight; Catecholamines; Heart; Male; Methado | 1978 |
Perinatal methadone exposure and its influence on the behavioral ontogeny of rats.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Female; Growth; Male; Methadone; Motor Activity; | 1978 |
Effects of neonatal or maternal methadone administration on ornithine decarboxylase activity in brain and heart of developing rats.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Carboxy-Lyases; Female; Heart; Methadone; Myoc | 1976 |
Kallikrein-kinin system in newborns of the drug addicted.
Topics: Aging; Carboxypeptidases; Female; Humans; Infant, Newborn; Kallikreins; Lysine Carboxypeptidase; Mal | 1989 |
Endocrine consequences of perinatal methadone exposure.
Topics: Aging; Animals; Animals, Newborn; Cyproheptadine; Disease Models, Animal; Hypothalamo-Hypophyseal Sy | 1987 |