Page last updated: 2024-10-30

methadone and Aging

methadone has been researched along with Aging in 37 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"People on methadone treatment have increased their life expectancy, aging prematurely with comorbidities."7.91[Aging in a methadone maintenance program. A perspective from the framework of social determinants of health]. ( Gutiérrez-Cáceres, S; Pedraz-Marcos, A; Serrano-Gallardo, P, 2019)
"People on methadone treatment have increased their life expectancy, aging prematurely with comorbidities."3.91[Aging in a methadone maintenance program. A perspective from the framework of social determinants of health]. ( Gutiérrez-Cáceres, S; Pedraz-Marcos, A; Serrano-Gallardo, P, 2019)
"The data for this analysis were derived from a qualitative study of the needs of aging methadone clients."3.75Mistrust and self-isolation: barriers to social support for older adult methadone clients. ( Rosen, D; Smith, ML, 2009)
"The lack of methadone pharmacokinetic data in children and neonates restrains dosing to achieve the target concentration in these populations."1.40The pharmacokinetics of methadone and its metabolites in neonates, infants, and children. ( Anderson, BJ; Drover, DR; Hammer, GB; Kern, S; Lugo, RA; Satterfield, K; Stemland, CJ; Tristani-Firouzi, M; Ward, RM, 2014)
"To compare the use of co-medication, the potential drug-drug interactions (PDDIs) and the effect on antiretroviral therapy (ART) tolerability and efficacy in HIV-infected individuals according to age, ≥ 50 years or <50 years."1.37Ageing with HIV: medication use and risk for potential drug-drug interactions. ( Back, D; Battegay, M; Bernasconi, E; Calmy, A; Cavassini, M; Elzi, L; Furrer, H; Khoo, S; Marzolini, C; Vernazza, P; Weber, R, 2011)
"Recent clinical studies suggest that substance use may be associated with an acceleration of the ageing process, possibly related to a deficit of stem cell number or function."1.35An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey. ( Reece, AS, 2008)
"Methadone was acquired by the perinatal guinea pig both transplacentally and via the milk, more agent being obtained by the former route."1.26Disposition of maternally-administered methadone and its effects on hepatic drug-metabolizing functions in perinatal guinea pigs. ( Ecobichon, DJ; Pak, RC, 1982)
"Methadone-exposed rats were found to be generally less active than controls at 21 days of age and more active than saline-treated pups at the 45 and 60 day test periods."1.26Development of motor activity in young rats following perinatal methadone exposure. ( McLaughlin, PJ; Thompson, CI; Zagon, IS, 1979)
"Methadone was administered daily to pregnant or nursing rats, or directly to neonates, and the effects on brain and heart weights and ornithine decarboxylase (ODC) activities were determined during postnatal development."1.26Effects of neonatal or maternal methadone administration on ornithine decarboxylase activity in brain and heart of developing rats. ( Bartolomé, M; Lau, C; Slotkin, TA, 1976)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199022 (59.46)18.7374
1990's1 (2.70)18.2507
2000's3 (8.11)29.6817
2010's11 (29.73)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gutiérrez-Cáceres, S1
Pedraz-Marcos, A1
Serrano-Gallardo, P1
Halim, AA1
Alsayed, B1
Embarak, S1
Yaseen, T1
Dabbous, S1
Fontaine, O1
Dueluzeau, R1
Raibaud, P1
Chabanet, C1
Popoff, MR1
Badoual, J1
Gabilan, JC1
Andremont, A1
Gómez, L1
Andrés, S1
Sánchez, J1
Alonso, JM1
Rey, J1
López, F1
Jiménez, A1
Yan, Z1
Zhou, L1
Zhao, Y3
Wang, J6
Huang, L2
Hu, K1
Liu, H4
Wang, H3
Guo, Z1
Song, Y1
Huang, H4
Yang, R1
Owen, TW1
Al-Kaysi, RO1
Bardeen, CJ1
Cheng, Q1
Wu, S1
Cheng, T1
Zhou, X1
Wang, B4
Zhang, Q4
Wu, X2
Yao, Y3
Ochiai, T1
Ishiguro, H2
Nakano, R2
Kubota, Y2
Hara, M1
Sunada, K1
Hashimoto, K1
Kajioka, J1
Fujishima, A1
Jiao, J3
Gai, QY3
Wang, W2
Zang, YP2
Niu, LL2
Fu, YJ3
Wang, X4
Yao, LP1
Qin, QP1
Wang, ZY1
Liu, J4
Aleksic Sabo, V1
Knezevic, P1
Borges-Argáez, R1
Chan-Balan, R1
Cetina-Montejo, L1
Ayora-Talavera, G1
Sansores-Peraza, P1
Gómez-Carballo, J1
Cáceres-Farfán, M1
Jang, J1
Akin, D1
Bashir, R1
Yu, Z1
Zhu, J2
Jiang, H1
He, C2
Xiao, Z1
Xu, J2
Sun, Q1
Han, D1
Lei, H1
Zhao, K2
Zhu, L1
Li, X4
Fu, H2
Wilson, BK1
Step, DL1
Maxwell, CL1
Gifford, CA1
Richards, CJ1
Krehbiel, CR1
Warner, JM1
Doerr, AJ1
Erickson, GE1
Guretzky, JA1
Rasby, RJ1
Watson, AK1
Klopfenstein, TJ1
Sun, Y4
Liu, Z3
Pham, TD1
Lee, BK1
Yang, FC1
Wu, KH1
Lin, WP1
Hu, MK1
Lin, L3
Shao, J1
Sun, M1
Xu, G1
Zhang, X6
Xu, N1
Wang, R1
Liu, S1
He, H1
Dong, X2
Yang, M2
Yang, Q1
Duan, S1
Yu, Y2
Han, J2
Zhang, C3
Chen, L2
Yang, X1
Li, W3
Wang, T2
Campbell, DA1
Gao, K1
Zager, RA1
Johnson, ACM1
Guillem, A1
Keyser, J1
Singh, B1
Steubl, D1
Schneider, MP1
Meiselbach, H1
Nadal, J1
Schmid, MC1
Saritas, T1
Krane, V1
Sommerer, C1
Baid-Agrawal, S1
Voelkl, J1
Kotsis, F1
Köttgen, A1
Eckardt, KU1
Scherberich, JE1
Li, H4
Yao, L2
Sun, L3
Zhu, Z1
Naren, N1
Zhang, XX2
Gentile, GL1
Rupert, AS1
Carrasco, LI1
Garcia, EM1
Kumar, NG1
Walsh, SW1
Jefferson, KK1
Guest, RL1
Samé Guerra, D1
Wissler, M1
Grimm, J1
Silhavy, TJ1
Lee, JH2
Yoo, JS1
Kim, Y1
Kim, JS2
Lee, EJ1
Roe, JH1
Delorme, M1
Bouchard, PA1
Simon, M1
Simard, S1
Lellouche, F1
D'Urzo, KA1
Mok, F1
D'Urzo, AD1
Koneru, B1
Lopez, G1
Farooqi, A1
Conkrite, KL1
Nguyen, TH1
Macha, SJ1
Modi, A1
Rokita, JL1
Urias, E1
Hindle, A1
Davidson, H1
Mccoy, K1
Nance, J1
Yazdani, V1
Irwin, MS1
Yang, S1
Wheeler, DA1
Maris, JM1
Diskin, SJ1
Reynolds, CP1
Abhilash, L1
Kalliyil, A1
Sheeba, V1
Hartley, AM2
Meunier, B2
Pinotsis, N1
Maréchal, A2
Xu, JY1
Genko, N1
Haraux, F1
Rich, PR1
Kamalanathan, M1
Doyle, SM1
Xu, C1
Achberger, AM1
Wade, TL1
Schwehr, K1
Santschi, PH1
Sylvan, JB1
Quigg, A1
Leong, W1
Xu, W2
Gao, S1
Zhai, X1
Wang, C2
Gilson, E1
Ye, J1
Lu, Y1
Yan, R1
Zhang, Y6
Hu, Z1
You, Q1
Cai, Q1
Yang, D1
Gu, S1
Dai, H1
Zhao, X1
Gui, C1
Gui, J1
Wu, PK1
Hong, SK1
Starenki, D1
Oshima, K1
Shao, H1
Gestwicki, JE1
Tsai, S1
Park, JI1
Wang, Y7
Zhao, R1
Gu, Z1
Dong, C2
Guo, G1
Li, L4
Barrett, HE1
Meester, EJ1
van Gaalen, K1
van der Heiden, K1
Krenning, BJ1
Beekman, FJ1
de Blois, E1
de Swart, J1
Verhagen, HJ1
Maina, T1
Nock, BA1
Norenberg, JP1
de Jong, M1
Gijsen, FJH1
Bernsen, MR1
Martínez-Milla, J1
Galán-Arriola, C1
Carnero, M1
Cobiella, J1
Pérez-Camargo, D1
Bautista-Hernández, V1
Rigol, M1
Solanes, N1
Villena-Gutierrez, R1
Lobo, M1
Mateo, J1
Vilchez-Tschischke, JP1
Salinas, B1
Cussó, L1
López, GJ1
Fuster, V1
Desco, M1
Sanchez-González, J1
Ibanez, B1
van den Berg, P1
Schweitzer, DH1
van Haard, PMM1
Geusens, PP1
van den Bergh, JP1
Zhu, X1
Huang, X2
Xu, H2
Yang, G2
Lin, Z1
Salem, HF1
Nafady, MM1
Kharshoum, RM1
Abd El-Ghafar, OA1
Farouk, HO1
Domiciano, D1
Nery, FC1
de Carvalho, PA1
Prudente, DO1
de Souza, LB1
Chalfun-Júnior, A1
Paiva, R1
Marchiori, PER1
Lu, M2
An, Z1
Jiang, J2
Li, J7
Du, S1
Zhou, H1
Cui, J1
Wu, W1
Liu, Y7
Song, J1
Lian, Q1
Uddin Ahmad, Z1
Gang, DD1
Konggidinata, MI1
Gallo, AA1
Zappi, ME1
Yang, TWW1
Johari, Y1
Burton, PR1
Earnest, A1
Shaw, K1
Hare, JL1
Brown, WA1
Kim, GA1
Han, S1
Choi, GH1
Choi, J1
Lim, YS1
Gallo, A1
Cancelli, C1
Ceron, E1
Covino, M1
Capoluongo, E1
Pocino, K1
Ianiro, G1
Cammarota, G1
Gasbarrini, A1
Montalto, M1
Somasundar, Y1
Lu, IC1
Mills, MR1
Qian, LY1
Olivares, X1
Ryabov, AD1
Collins, TJ1
Zhao, L1
Doddipatla, S1
Thomas, AM1
Nikolayev, AA1
Galimova, GR1
Azyazov, VN1
Mebel, AM1
Kaiser, RI1
Guo, S1
Yang, P1
Yu, X2
Wu, Y2
Zhang, H1
Yu, B2
Han, B1
George, MW1
Moor, MB1
Bonny, O1
Langenberg, E1
Paik, H1
Smith, EH1
Nair, HP1
Hanke, I1
Ganschow, S1
Catalan, G1
Domingo, N1
Schlom, DG1
Assefa, MK1
Wu, G2
Hayton, TW1
Becker, B1
Enikeev, D1
Netsch, C1
Gross, AJ1
Laukhtina, E1
Glybochko, P1
Rapoport, L1
Herrmann, TRW1
Taratkin, M1
Dai, W1
Shi, J2
Carreno, J1
Kloner, RA1
Pickersgill, NA1
Vetter, JM1
Kim, EH1
Cope, SJ1
Du, K1
Venkatesh, R1
Giardina, JD1
Saad, NES1
Bhayani, SB1
Figenshau, RS1
Eriksson, J1
Landfeldt, E1
Ireland, S1
Jackson, C1
Wyatt, E1
Gaudig, M1
Stancill, JS1
Happ, JT1
Broniowska, KA1
Hogg, N1
Corbett, JA1
Tang, LF1
Bi, YL1
Fan, Y2
Sun, YB1
Wang, AL1
Xiao, BH1
Wang, LF1
Qiu, SW1
Guo, SW1
Wáng, YXJ1
Sun, J2
Chu, S1
Pan, Q1
Li, D2
Zheng, S2
Ma, L1
Wang, L3
Hu, T1
Wang, F1
Han, Z1
Yin, Z1
Ge, X1
Xie, K1
Lei, P1
Dias-Santagata, D1
Lennerz, JK1
Sadow, PM1
Frazier, RP1
Govinda Raju, S1
Henry, D1
Chung, T1
Kherani, J1
Rothenberg, SM1
Wirth, LJ1
Marti, CN1
Choi, NG1
Bae, SJ1
Ni, L1
Luo, X1
Dai, T1
Yang, Y3
Lee, R1
Fleischer, AS1
Wemhoff, AP1
Ford, CR1
Kleppinger, EL1
Helms, K1
Bush, AA1
Luna-Abanto, J1
García Ruiz, L1
Laura Martinez, J1
Álvarez Larraondo, M1
Villoslada Terrones, V1
Dukic, L1
Maric, N1
Simundic, AM1
Chogtu, B1
Ommurugan, B1
Thomson, SR1
Kalthur, SG1
Benidir, M1
El Massoudi, S1
El Ghadraoui, L1
Lazraq, A1
Benjelloun, M1
Errachidi, F1
Cassar, M1
Law, AD1
Chow, ES1
Giebultowicz, JM1
Kretzschmar, D1
Salonurmi, T1
Nabil, H1
Ronkainen, J1
Hyötyläinen, T1
Hautajärvi, H1
Savolainen, MJ1
Tolonen, A1
Orešič, M1
Känsäkoski, P1
Rysä, J1
Hakkola, J1
Hukkanen, J1
Zhu, N1
Li, Y4
Du, Q1
Hao, P1
Cao, X1
Li, CX1
Zhao, S1
Luo, XM1
Feng, JX1
Gonzalez-Cotto, M1
Guo, L1
Karwan, M1
Sen, SK1
Barb, J1
Collado, CJ1
Elloumi, F1
Palmieri, EM1
Boelte, K1
Kolodgie, FD1
Finn, AV1
Biesecker, LG1
McVicar, DW1
Qu, F1
Deng, Z1
Xie, Y2
Tang, J3
Chen, Z2
Luo, W1
Xiong, D1
Zhao, D1
Fang, J1
Zhou, Z1
Niu, PP1
Song, B1
Xu, YM1
Zhang, Z2
Qiu, N1
Yin, J1
Zhang, J3
Guo, W1
Liu, M2
Liu, T2
Chen, D5
Luo, K1
He, Z2
Zheng, G1
Xu, F1
Sun, W1
Yin, F1
van Hest, JCM1
Du, L2
Shi, X1
Kang, S1
Duan, W1
Zhang, S2
Feng, J2
Qi, N1
Shen, G1
Ren, H1
Shang, Q1
Zhao, W2
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Jiang, X2
Alame, M1
Cornillot, E1
Cacheux, V1
Tosato, G1
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Chen, CS1
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Yu, J1
Tian, J1
Zhao, M1
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Yao, C1
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Tzou, DT1
Washington, SL1
Hu, W1
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Bailey, MR1
Hsi, RS1
Cunitz, BW1
Simon, J1
Wang, YN1
Dunmire, BL1
Paun, M1
Starr, F1
Lu, W1
Evan, AP1
Harper, JD1
Han, G1
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Fouladvand, F1
Falahi, E1
Asbaghi, O1
Abbasnezhad, A1
Anigboro, AA1
Avwioroko, OJ1
Cholu, CO1
Sonei, A1
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Kanaani, L1
Jahromy, MH1
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Hong, KB1
Suh, HJ1
Park, JH1
Shin, E1
Park, E1
Kouakou-Kouamé, CA1
N'guessan, FK1
Montet, D1
Djè, MK1
Kim, GD1
González-Fernández, D1
Pons, EDC1
Rueda, D1
Sinisterra, OT1
Murillo, E1
Scott, ME1
Koski, KG1
Shete, PB1
Gonzales, R1
Ackerman, S1
Cattamanchi, A1
Handley, MA1
Li, XX1
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Gu, FF1
He, WP1
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Heffernan, JK1
Valgepea, K1
de Souza Pinto Lemgruber, R1
Casini, I1
Plan, M1
Tappel, R1
Simpson, SD1
Köpke, M1
Nielsen, LK1
Marcellin, E1
Cen, YK1
Lin, JG1
Wang, YL1
Wang, JY1
Liu, ZQ1
Zheng, YG1
Spirk, D1
Noll, S1
Burnier, M1
Rimoldi, S1
Noll, G1
Sudano, I1
Penzhorn, BL1
Oosthuizen, MC1
Kobos, LM1
Alqatani, S1
Ferreira, CR1
Aryal, UK1
Hedrick, V1
Sobreira, TJP1
Shannahan, JH1
Gale, P1
Singhroy, DN1
MacLean, E1
Kohli, M1
Lessem, E1
Branigan, D1
England, K1
Suleiman, K1
Drain, PK1
Ruhwald, M1
Schumacher, S1
Denkinger, CM1
Waning, B1
Van Gemert, W1
Pai, M1
Myers, RK1
Bonsu, JM1
Carey, ME1
Yerys, BE1
Mollen, CJ1
Curry, AE1
Douglas, TA1
Alinezhadbalalami, N1
Balani, N1
Schmelz, EM1
Davalos, RV1
Kamaldinov, T1
Erndt-Marino, J1
Levin, M1
Kaplan, DL1
Hahn, MS1
Heidarimoghadam, R1
Farmany, A1
Lee, JJ1
Kang, J1
Park, S1
Cho, JH1
Oh, S1
Park, DJ1
Perez-Maldonado, R1
Cho, JY1
Park, IH1
Kim, HB1
Song, M1
Mfarrej, B1
Jofra, T1
Morsiani, C1
Gagliani, N1
Fousteri, G1
Battaglia, M1
Giuliano, C1
Levinger, I1
Vogrin, S1
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Allen, JD1
Lv, Y1
Yuan, R1
Cai, B1
Bahrami, B1
Chowdhury, AH1
Yang, C2
Qiao, Q1
Liu, SF1
Zhang, WH1
Kolano, L1
Knappe, D1
Volke, D1
Sträter, N1
Hoffmann, R1
Coussens, M1
Calders, P1
Lapauw, B1
Celie, B1
Banica, T1
De Wandele, I1
Pacey, V1
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Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-blind, Controlled, Multi-site Study of the Pharmacokinetics and Pharmacodynamics of Methadone vs. Morphine During Mechanical Ventilation Following Cardiac Surgery in Neonates, Infants and Children[NCT01094522]Phase 1/Phase 247 participants (Actual)Interventional2010-03-31Completed
Methadone for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery[NCT03778372]55 participants (Actual)Observational2019-01-01Completed
Safety and Single Dose Population Pharmacokinetics and Bioavailability of Methadone and Its Enantiomers in Newborns and Young Infants At 29-48 Weeks Post Menstrual Age[NCT00715988]Phase 17 participants (Actual)Interventional2007-10-31Completed
The Effect of Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery: A Randomized, Double-Blinded Controlled Trial[NCT02747875]26 participants (Actual)Interventional2016-09-30Terminated (stopped due to Drug Shortage)
Bictegravir in the Elderly Living With HIV: Impact of Polypharmacy and Multimorbidity (BICEP)[NCT05064020]162 participants (Anticipated)Observational2020-08-01Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

•Amount of Study Drug Administered During the 24-hour Dosing Period

(NCT01094522)
Timeframe: 24 hours

Interventionmg (Mean)
Methadone8.56
Morphine13.77

•Pain Scores (FLACC) During the 24 Hours Study Period

"Average of hourly FLACC score for each subject over 24 hours was calculated, followed by median and full range for total subjects in each arm.~FLACC (Face, Leg, Activity, Cry, Consolability) score ranges from 0-10 with 0 representing no pain" (NCT01094522)
Timeframe: 24 hours

Interventionunits on a scale (Median)
Methadone1.375
Morphine1.917

Maximum Concentration of Methadone Including Its Metabolites (EDDP and EMDP)

(NCT01094522)
Timeframe: 0, 15, 30 minutes, 1, 2, 4, 6 hrs, every 6 hrs up to 24 hrs

Interventionng/mL (Median)
MethadoneEDDPEMDP
Methadone52.353.420.194

Maximum Concentration of Morphine Including Its Metabolites (Morphine-3-glucuronide and Morphine-6-glucuronide)

(NCT01094522)
Timeframe: 0, 15, 30 minutes, 1, 2, 4, 6 hrs, every 6 hrs up to 24 hrs

Interventionng/mL (Median)
MorphineM3GM6G
Morphine27.5522522.95

Total Opioid Dose, in Morphine Equivalents, in the First 24 Hours After Pediatric Cardiac Bypass Surgery.

The distribution of the total opioid dose in the first 24 hours will be evaluated by randomization group (methadone vs. fentanyl) and differences between groups will be tested. It is hypothesized that compared to fentanyl, methadone administered intraoperative will result in a significantly lower total opioid dose (morphine or oxycodone) during the first 24 hour postoperative period. Assuming no difference between the two treatment strategies in the population, a total sample size of 52 in each group will provide 80% power to detect an effect size of 0.1. Significance will be measured as a 30% reduction in postoperative pain requirement. (NCT02747875)
Timeframe: 24 hours

Interventionmg postop morphine equivelant 24hr (Mean)
Control - Fentanyl0.55
Treatment - Methadone0.48

Opioid-related Adverse Events Including: Respiratory Failure, Cardiovascular Instability, and Postoperative Nausea and Vomiting

Opioid-related adverse events will be monitored closely and a secondary analysis will compare the incidence of side effects between the two groups during the first 24-hour postoperative period. The Pearson's contingency chi-square test will be used to evaluate any differences between the randomization groups in opioid-related adverse events during the first 24-hour postoperative period. (NCT02747875)
Timeframe: 24 hours

,
Interventionevents (Mean)
Ondansetron DosesEmesis EpisodesHypoventilation EpisodesArrhythmias
Control - Fentanyl3.812.7200
Treatment - Methadone3.432.0800

Reviews

2 reviews available for methadone and Aging

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
The relationship of pharmacokinetics to pharmacological activity: morphine, methadone and naloxone.
    Clinical pharmacokinetics, 1976, Volume: 1, Issue:3

    Topics: Absorption; Aging; Aspirin; Blood Proteins; Dose-Response Relationship, Drug; Drug Interactions; Fem

1976

Trials

2 trials available for methadone and Aging

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
Less impairment on one portion of a driving-relevant psychomotor battery in buprenorphine-maintained than in methadone-maintained patients: results of a randomized clinical trial.
    Journal of clinical psychopharmacology, 2005, Volume: 25, Issue:5

    Topics: Adult; Aging; Attention; Automobile Driving; Buprenorphine; Cognition; Female; Humans; Male; Memory,

2005

Other Studies

34 other studies available for methadone and Aging

ArticleYear
[Aging in a methadone maintenance program. A perspective from the framework of social determinants of health].
    Revista espanola de salud publica, 2019, Aug-26, Volume: 93

    Topics: Adult; Age of Onset; Aging; Comorbidity; Female; Hepatitis C; HIV Infections; Humans; Life Expectanc

2019
Methadone Maintenance Treatment for Older Adults: Cost and Logistical Considerations.
    Psychiatric services (Washington, D.C.), 2018, 03-01, Volume: 69, Issue:3

    Topics: Aged; Aging; Analgesics, Opioid; Humans; Medicare; Methadone; Middle Aged; Opiate Substitution Treat

2018
Inflammatory chemokine eotaxin-1 is correlated with age in heroin dependent patients under methadone maintenance therapy.
    Drug and alcohol dependence, 2018, 02-01, Volume: 183

    Topics: Adult; Aging; Amyloid beta-Peptides; Brain; Case-Control Studies; Chemokine CCL11; Cotinine; Female;

2018
Ageing opioid users' increased risk of methadone-specific death in the UK.
    The International journal on drug policy, 2018, Volume: 55

    Topics: Adolescent; Adult; Aging; Analgesics, Opioid; Databases, Factual; Female; Heroin; Humans; Male; Meth

2018
An ageing methadone population: A challenge for treating doctors.
    Australian journal of general practice, 2019, Volume: 48, Issue:3

    Topics: Aging; General Practice; Humans; Medication Reconciliation; Methadone; Opiate Substitution Treatment

2019
Impact of opioid pharmacotherapy on arterial stiffness and vascular ageing: cross-sectional and longitudinal studies.
    Cardiovascular toxicology, 2013, Volume: 13, Issue:3

    Topics: Adult; Aging; Blood Vessels; Buprenorphine; Cross-Sectional Studies; Endothelium, Vascular; Female;

2013
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
The pharmacokinetics of methadone and its metabolites in neonates, infants, and children.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:6

    Topics: Adolescent; Aging; Algorithms; Analgesics, Opioid; Child; Child, Preschool; Computer Simulation; Ele

2014
An intriguing association between dental and mental pathology in addicted and control subjects: a cross-sectional survey.
    British dental journal, 2008, Dec-13, Volume: 205, Issue:11

    Topics: Adolescent; Adult; Aggression; Aging; Alcohol Drinking; Amphetamine-Related Disorders; Anxiety; Atte

2008
Mistrust and self-isolation: barriers to social support for older adult methadone clients.
    Journal of gerontological social work, 2009, Volume: 52, Issue:7

    Topics: Aging; Female; Humans; Interviews as Topic; Male; Methadone; Middle Aged; Midwestern United States;

2009
Differing age related trajectories of dysfunction in several organ systems in opiate dependence.
    Aging clinical and experimental research, 2012, Volume: 24, Issue:1

    Topics: Adult; Aged; Aging; Aging, Premature; Analgesics, Opioid; Disease Progression; Female; Hair Color; H

2012
Ageing with HIV: medication use and risk for potential drug-drug interactions.
    The Journal of antimicrobial chemotherapy, 2011, Volume: 66, Issue:9

    Topics: Adult; Aged; Aging; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cardiovascular Agents; C

2011
Gender differences in physical and mental health outcomes among an aging cohort of individuals with a history of heroin dependence.
    Addictive behaviors, 2012, Volume: 37, Issue:3

    Topics: Adult; Aged; Aging; California; Female; Follow-Up Studies; Health Status; Heroin Dependence; Humans;

2012
Delays in growth and biochemical development of rat brain caused by maternal methadone administration: are the alterations in synaptogenesis and cellular maturation independent of reduced maternal food intake?
    Developmental neuroscience, 1982, Volume: 5, Issue:1

    Topics: Aging; Animals; Body Weight; Brain; Eating; Female; Methadone; Organ Size; Ornithine Decarboxylase;

1982
Motoric and attentional behavior in infants of methadone-maintained women.
    NIDA research monograph, 1983, Volume: 43

    Topics: Aging; Attention; Behavior; Female; Humans; Infant; Male; Methadone; Motor Activity; Opioid-Related

1983
Endocrine effects of methadone in rats; acute effects in adults.
    European journal of pharmacology, 1983, Nov-25, Volume: 95, Issue:3-4

    Topics: Aging; Animals; Corticosterone; Dose-Response Relationship, Drug; Female; Growth Hormone; Hormones;

1983
Methadone in brain and its effects on locomotor activity of young and aged mice.
    Neurobiology of aging, 1983,Winter, Volume: 4, Issue:4

    Topics: Aging; Animals; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Male; Methadone; Mice

1983
Age-dependent alterations in the accumulation of l-methadone in the brain synaptosomes and other subcellular fractions.
    Developmental pharmacology and therapeutics, 1984, Volume: 7, Issue:2

    Topics: Aging; Animals; Brain; Methadone; Rats; Rats, Inbred Strains; Subcellular Fractions; Synaptosomes

1984
Disposition of maternally-administered methadone and its effects on hepatic drug-metabolizing functions in perinatal guinea pigs.
    Biochemical pharmacology, 1982, Sep-15, Volume: 31, Issue:18

    Topics: Aging; Animals; Animals, Newborn; Blood Proteins; Female; Glucuronosyltransferase; Guinea Pigs; Live

1982
Ontogeny of endocrine responses to methadone in rats.
    Life sciences, 1983, Apr-25, Volume: 32, Issue:17

    Topics: Aging; Animals; Corticosterone; Growth Hormone; Kinetics; Methadone; Naloxone; Pituitary Hormones; P

1983
Effect of prior narcotic addiction on response to treatment of alcoholism.
    Alcoholism, clinical and experimental research, 1980, Volume: 4, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Alcoholism; Female; Heroin Dependence; Humans; Male; Marriage; Metha

1980
Toxic effects of maternal methadone administration on cardiac development in the neonatal rat: potential participation of altered polyamine levels in growth impairment.
    Toxicology letters, 1982, Volume: 14, Issue:3-4

    Topics: Aging; Animals; Animals, Newborn; Female; Heart; Methadone; Myocardium; Ornithine Decarboxylase; Pol

1982
Long-term thermoregulatory changes following perinatal methadone exposure in rats.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 14, Issue:5

    Topics: Aging; Animals; Body Temperature Regulation; Body Weight; Cold Temperature; Defecation; Eating; Hot

1981
In contrast to cocaine, prenatal exposure to methadone does not produce detectable alterations in the developing mouse brain.
    Brain research. Developmental brain research, 1998, Sep-10, Volume: 110, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Astrocytes; Brain; Cerebral Cortex; Cocaine; Cocaine-Related Disor

1998
The aging addict: a longitudinal study of known abusers.
    Addictive diseases, 1978, Volume: 3, Issue:3

    Topics: Adult; Age Factors; Aging; Ethnicity; Female; Heroin Dependence; History, 19th Century; History, 20t

1978
Pharmacological effects and metabolic fate of levo-methadone during postnatal development in rat.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 208, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Apomorphine; Behavior, Animal; Blood Proteins; Brain; Methadone; N

1979
Development of motor activity in young rats following perinatal methadone exposure.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 10, Issue:5

    Topics: Aging; Animals; Behavior, Animal; Body Weight; Female; Male; Methadone; Motor Activity; Rats

1979
Methadone exposure in utero: developmental status at one and two years of age.
    Pharmacology, biochemistry, and behavior, 1979, Volume: 11 Suppl

    Topics: Aging; Female; Growth; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Intelligence Test

1979
Effects of prenatal methadone on the rest-activity cycle of the pre-weanling rat.
    Neurobehavioral toxicology, 1979,Spring, Volume: 1, Issue:1

    Topics: Aging; Animals; Female; Methadone; Motor Activity; Pregnancy; Rats; Sleep; Time Factors

1979
Behavioral effects of fetal and neonatal exposure to methadone in the rat.
    Neurobehavioral toxicology, 1979,Spring, Volume: 1, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Emotions; Female; Fetus; Growth; Male; Methadone; Pre

1979
Responses of heart ornithine decarboxylase and adrenal catecholamines to methadone and sympathetic stimulants in developing and adults rats.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 205, Issue:1

    Topics: Adrenal Medulla; Aging; Animals; Animals, Newborn; Body Weight; Catecholamines; Heart; Male; Methado

1978
Perinatal methadone exposure and its influence on the behavioral ontogeny of rats.
    Pharmacology, biochemistry, and behavior, 1978, Volume: 9, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Female; Growth; Male; Methadone; Motor Activity;

1978
Effects of neonatal or maternal methadone administration on ornithine decarboxylase activity in brain and heart of developing rats.
    The Journal of pharmacology and experimental therapeutics, 1976, Volume: 199, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Carboxy-Lyases; Female; Heart; Methadone; Myoc

1976
Kallikrein-kinin system in newborns of the drug addicted.
    Advances in experimental medicine and biology, 1989, Volume: 247B

    Topics: Aging; Carboxypeptidases; Female; Humans; Infant, Newborn; Kallikreins; Lysine Carboxypeptidase; Mal

1989
Endocrine consequences of perinatal methadone exposure.
    NIDA research monograph, 1987, Volume: 78

    Topics: Aging; Animals; Animals, Newborn; Cyproheptadine; Disease Models, Animal; Hypothalamo-Hypophyseal Sy

1987