methadone has been researched along with Adverse Drug Event in 24 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " He was prescribed methadone and then subsequently developed bilateral peripheral oedema." | 8.90 | Methadone and oedema in the palliative care setting: a case report and review of the literature. ( Buchanan, D; Dawson, C; McFatter, F; Paterson, F, 2014) |
| "A hospital-based retrospective case series analysis of admissions related to prescription drug poisonings associated with methadone, opioid analgesics, antidepressants or benzodiazepines for hospitals in Clark County, Nevada between 2009 and 2013 was employed." | 7.85 | Retrospective case series analysis of characteristics and trends in unintentional pharmaceutical drug poisoning by methadone, opioid analgesics, antidepressants and benzodiazepines in Clark County, NV 2009-13. ( Bruno, T; Pharr, JR, 2017) |
| "Per oral methadone maintenance therapy [MMT] was introduced as part of harm reduction strategy to manage rising numbers of HIV infections caused by intravenous use of illicit drugs." | 5.41 | Side Effects of Chronic Methadone Use in Opioid Addiction: A Scoping Review on Hematological Derangements. ( Ang, WC; Anuar, A; Jamaluddin, R; Khalid, K, 2023) |
| " He was prescribed methadone and then subsequently developed bilateral peripheral oedema." | 4.90 | Methadone and oedema in the palliative care setting: a case report and review of the literature. ( Buchanan, D; Dawson, C; McFatter, F; Paterson, F, 2014) |
| "A hospital-based retrospective case series analysis of admissions related to prescription drug poisonings associated with methadone, opioid analgesics, antidepressants or benzodiazepines for hospitals in Clark County, Nevada between 2009 and 2013 was employed." | 3.85 | Retrospective case series analysis of characteristics and trends in unintentional pharmaceutical drug poisoning by methadone, opioid analgesics, antidepressants and benzodiazepines in Clark County, NV 2009-13. ( Bruno, T; Pharr, JR, 2017) |
| " Compared to other opioids, methadone has a longer duration of action, rapid onset, extended dosing intervals, high oral bioavailability, low cost, lack of active metabolites, and action on multiple receptors." | 3.01 | What we know and what we don't know about the perioperative use of methadone in children and adolescents. ( Boisvert-Plante, V; Einhorn, LM; Ingelmo, P; Poulin-Harnois, C, 2023) |
| " This study examined occurrences of serious adverse events (SAEs) reported in multicenter psychosocial trials of the National Institute on Drug Abuse Clinical Trials Network." | 2.73 | Serious adverse events in randomized psychosocial treatment studies: safety or arbitrary edicts? ( Ball, SA; Blaine, J; Carroll, KM; Kirby, KC; McCarty, D; Peirce, JM; Petry, NM; Roll, JM; Rounsaville, BJ; Stitzer, M, 2008) |
| "Methadone was reported to be most frequently associated with the occurrence of ADR (n=82/46." | 1.46 | Drug safety and adverse drug reaction reporting behavior related to outpatient opioid replacement therapy: Results from a survey among physicians. ( Cabanis, M; Connemann, BJ; Eller, J; Freudenmann, RW; Gahr, M; Hiemke, C; Lang, D; Schönfeldt-Lecuona, C, 2017) |
| "Methadone was by far the leading medication implicated in the development of TdP and an independent predictor in both univariate and multivariate analyses despite the fact that it was not the most common QT-prolonging medication in our population." | 1.43 | Drug-induced torsades de pointes in an underserved urban population. Methadone: is there therapeutic equipoise? ( Baldinger, SH; Di Biase, L; Engstrom, K; Ferrick, KJ; Fisher, JD; Garcia, MJ; Golive, A; Goodman-Meza, D; Gross, J; Kim, S; Krumerman, A; Makkiya, M; Medrano, F; Rangasamy, S; Romero, J; Valencia, CR, 2016) |
| "Poisoning is the leading cause of injury death in the United States (1)." | 1.40 | Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011. ( Chen, LH; Hedegaard, H; Warner, M, 2014) |
| "Methadone was used for a total of 925 patient-days." | 1.35 | Methadone analgesia for children with advanced cancer. ( Davies, D; DeVlaming, D; Haines, C, 2008) |
| " It addressed: safe storage of methadone takeaways; knowledge of risk of methadone ingestion by small children; and information provision from health care providers about the safe storage of methadone." | 1.34 | Safe storage of methadone takeaway doses - a survey of patient practice. ( Lea, T; Winstock, AR, 2007) |
| " The information was collectively considered and, using the best available evidence, translated into safe dosing guidelines for methadone induction." | 1.33 | Methadone induction doses: are our current practices safe? ( Kahan, M; Srivastava, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 10 (41.67) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Khalid, K | 1 |
| Anuar, A | 1 |
| Ang, WC | 1 |
| Jamaluddin, R | 1 |
| Boisvert-Plante, V | 1 |
| Poulin-Harnois, C | 1 |
| Ingelmo, P | 1 |
| Einhorn, LM | 1 |
| Konakanchi, JS | 1 |
| Sethi, R | 1 |
| Haber, PS | 1 |
| Elsayed, M | 1 |
| Espinoza, D | 1 |
| Lintzeris, N | 1 |
| Veillard, AS | 1 |
| Hallinan, R | 1 |
| Mueller, EA | 1 |
| Kirch, W | 1 |
| Dawson, C | 1 |
| Paterson, F | 1 |
| McFatter, F | 1 |
| Buchanan, D | 1 |
| Chen, LH | 1 |
| Hedegaard, H | 1 |
| Warner, M | 1 |
| Romero, J | 1 |
| Baldinger, SH | 1 |
| Goodman-Meza, D | 1 |
| Engstrom, K | 1 |
| Valencia, CR | 1 |
| Golive, A | 1 |
| Medrano, F | 1 |
| Rangasamy, S | 1 |
| Makkiya, M | 1 |
| Fisher, JD | 1 |
| Gross, J | 1 |
| Krumerman, A | 1 |
| Kim, S | 1 |
| Garcia, MJ | 1 |
| Di Biase, L | 1 |
| Ferrick, KJ | 1 |
| Bruno, T | 1 |
| Pharr, JR | 1 |
| Gahr, M | 1 |
| Eller, J | 1 |
| Cabanis, M | 1 |
| Hiemke, C | 1 |
| Freudenmann, RW | 1 |
| Connemann, BJ | 1 |
| Lang, D | 1 |
| Schönfeldt-Lecuona, C | 1 |
| Petry, NM | 1 |
| Roll, JM | 1 |
| Rounsaville, BJ | 1 |
| Ball, SA | 1 |
| Stitzer, M | 1 |
| Peirce, JM | 1 |
| Blaine, J | 1 |
| Kirby, KC | 1 |
| McCarty, D | 1 |
| Carroll, KM | 1 |
| Bunn, TL | 1 |
| Yu, L | 1 |
| Spiller, HA | 1 |
| Singleton, M | 1 |
| Matlock, A | 1 |
| Allan, N | 1 |
| Wills, B | 1 |
| Kang, C | 1 |
| Leikin, JB | 1 |
| SCHMIDT, G | 1 |
| Ryle, PR | 1 |
| Srivastava, A | 1 |
| Kahan, M | 1 |
| Winstock, AR | 1 |
| Lea, T | 1 |
| POWERS, BR | 1 |
| Davies, D | 1 |
| DeVlaming, D | 1 |
| Haines, C | 1 |
| Fossati, C | 1 |
| Wilson, D | 1 |
| Lewit, T | 1 |
| Penn, AS | 1 |
| Rowland, LP | 1 |
| Fraser, DW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Test of a Workforce Development Intervention to Expand Buprenorphine Prescribers[NCT02926482] | 76 participants (Actual) | Interventional | 2016-10-26 | Completed | |||
| PRevention Of Methamphetamine Use Among Postpartum Women Trial (PROMPT)[NCT05128071] | Early Phase 1 | 40 participants (Anticipated) | Interventional | 2022-02-04 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for methadone and Adverse Drug Event
| Article | Year |
|---|---|
Side Effects of Chronic Methadone Use in Opioid Addiction: A Scoping Review on Hematological Derangements.
Topics: Drug-Related Side Effects and Adverse Reactions; HIV Infections; Humans; Methadone; Opioid-Related D | 2023 |
What we know and what we don't know about the perioperative use of methadone in children and adolescents.
Topics: Adolescent; Analgesics; Analgesics, Opioid; Child; Drug-Related Side Effects and Adverse Reactions; | 2023 |
The Growing Epidemic of Opioid Use Disorder in the Elderly and Its Treatment: A Review of the Literature.
Topics: Aged; Analgesics, Opioid; Buprenorphine; Drug-Related Side Effects and Adverse Reactions; Humans; Me | 2023 |
[Levamethadone as substitution treatment of opioid-dependent patients].
Topics: Analgesics, Opioid; Comorbidity; Drug-Related Side Effects and Adverse Reactions; Germany; Methadone | 2013 |
Methadone and oedema in the palliative care setting: a case report and review of the literature.
Topics: Adult; Alfentanil; Analgesics, Opioid; Back Pain; Drug Administration Schedule; Drug-Related Side Ef | 2014 |
Justification for routine screening of pharmaceutical products in immune function tests: a review of the recommendations of Putman et al. (2003).
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Buprenorphine; Drug Evaluation, Preclinical; Drug-Rela | 2005 |
[Pulmonary diseases due to drugs. II].
Topics: Amines; Amitriptyline; Beclomethasone; Drug-Related Side Effects and Adverse Reactions; Heroin; Huma | 1974 |
1 trial available for methadone and Adverse Drug Event
| Article | Year |
|---|---|
Serious adverse events in randomized psychosocial treatment studies: safety or arbitrary edicts?
Topics: Adult; Counseling; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Heroi | 2008 |
16 other studies available for methadone and Adverse Drug Event
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Constipation and other common symptoms reported by women and men in methadone and buprenorphine maintenance treatment.
Topics: Adult; Analgesics, Opioid; Australia; Buprenorphine; Case-Control Studies; Constipation; Depression; | 2017 |
Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011.
Topics: Adult; Age Distribution; Analgesics, Opioid; Benzodiazepines; Black or African American; Drug Overdo | 2014 |
Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011.
Topics: Adult; Age Distribution; Analgesics, Opioid; Benzodiazepines; Black or African American; Drug Overdo | 2014 |
Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011.
Topics: Adult; Age Distribution; Analgesics, Opioid; Benzodiazepines; Black or African American; Drug Overdo | 2014 |
Drug-poisoning Deaths Involving Opioid Analgesics: United States, 1999-2011.
Topics: Adult; Age Distribution; Analgesics, Opioid; Benzodiazepines; Black or African American; Drug Overdo | 2014 |
Drug-induced torsades de pointes in an underserved urban population. Methadone: is there therapeutic equipoise?
Topics: Age Distribution; Causality; Comorbidity; Drug-Related Side Effects and Adverse Reactions; Female; H | 2016 |
Retrospective case series analysis of characteristics and trends in unintentional pharmaceutical drug poisoning by methadone, opioid analgesics, antidepressants and benzodiazepines in Clark County, NV 2009-13.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Antidepressive Agents; Benzodiazepin | 2017 |
Drug safety and adverse drug reaction reporting behavior related to outpatient opioid replacement therapy: Results from a survey among physicians.
Topics: Analgesics, Opioid; Buprenorphine; Drug-Related Side Effects and Adverse Reactions; Female; Germany; | 2017 |
Surveillance of methadone-related poisonings in Kentucky using multiple data sources.
Topics: Adult; Adverse Drug Reaction Reporting Systems; Data Collection; Drug-Related Side Effects and Adver | 2010 |
A continuing black hole? The FDA boxed warning: an appeal to improve its clinical utility.
Topics: Antipsychotic Agents; Droperidol; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Hi | 2011 |
[Problem of lethal dose and detection of polamidon, with a fatal case of medicinal poisoning].
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Hypnotics and Sedatives; Methadone; Poisoni | 1955 |
Methadone induction doses: are our current practices safe?
Topics: Age Factors; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Drug-Related Side Eff | 2006 |
Safe storage of methadone takeaway doses - a survey of patient practice.
Topics: Accident Prevention; Adult; Data Collection; Drug Prescriptions; Drug Storage; Drug-Related Side Eff | 2007 |
Use of methadone to combat withdrawal symptoms of dilaudid addiction; case report.
Topics: Behavior, Addictive; Drug-Related Side Effects and Adverse Reactions; Humans; Hydromorphone; Methado | 1949 |
Methadone analgesia for children with advanced cancer.
Topics: Adolescent; Analgesia; Analgesics, Opioid; Child; Child, Preschool; Drug Evaluation; Drug-Related Si | 2008 |
[Drugs and the treatment of drug addiction].
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Methadone; Substance-Related Disorders | 1976 |
Experience with drugs and driving in Queensland, Australia.
Topics: Australia; Automobile Driving; Diazepam; Diphenhydramine; Drug Interactions; Drug-Related Side Effec | 1985 |
Drugs, coma, and myoglobinuria.
Topics: Acute Kidney Injury; Adult; Aspartate Aminotransferases; Barbiturates; Chlorpromazine; Coma; Drug-Re | 1972 |