Page last updated: 2024-10-30

methadone and Acute Post-Traumatic Stress Disorder

methadone has been researched along with Acute Post-Traumatic Stress Disorder in 15 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Research Excerpts

ExcerptRelevanceReference
"Differences in lifetime trauma exposure and screened symptoms of posttraumatic stress disorder (PTSD) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences."7.77Exploring relations among traumatic, posttraumatic, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Cutter, CJ; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2011)
" Factors associated with recent suicide attempts were: being an RR entrant, female gender, younger age, less education, more extensive polydrug use, benzodiazepine use, recent heroin overdose, Major Depression, current suicidal ideation, Borderline Personality Disorder (BPD)and Post-Traumatic Stress Disorder."7.72Attempted suicide among entrants to three treatment modalities for heroin dependence in the Australian Treatment Outcome Study (ATOS): prevalence and risk factors. ( Darke, S; Lynskey, M; Ross, J; Teesson, M, 2004)
"The aims of this pilot study were: (a) to test the feasibility of prolonged exposure (PE) therapy conducted by a social worker staff on female patients in methadone program clinics who were survivors of child sexual abuse or rape and (b) to examine preliminary outcomes of PE on posttraumatic stress disorder (PTSD), depression, and illicit drug use at pre- and posttreatment, and up to 12-month follow-ups."5.20Prolonged Exposure for Treating PTSD Among Female Methadone Patients Who Were Survivors of Sexual Abuse in Israel. ( Foa, EB; Katz, N; Levit, S; Nacasch, N; Schiff, M, 2015)
"Following our finding of high rates of obsessive compulsive disorder (OCD) among methadone maintained (MMT) former opiate addict women with a history of childhood sexual abuse, we compared 68 MMT sexually abused women to 48 women from a Sexual Abuse Treatment Center (SATC) without a history of opiate addiction, for clinical-OCD (Yale-Brown Obsessive Compulsive Scale), dissociation (Dissociative Experiences Scale (DES), complex-post-traumatic stress disorder (PTSD) (Structured Interview for Disorders of Extreme Stress - Non-Other Specify), sexual PTSD (the Clinician-Administered PTSD Scale) and trauma events history (Life Event Inventory)."3.80Psychiatric comorbidity differences between women with history of childhood sexual abuse who are methadone-maintained former opiate addicts and non-addicts. ( Adelson, M; Bloch, M; Peles, E; Potik, D; Schreiber, S; Seligman, Z, 2014)
"Differences in lifetime trauma exposure and screened symptoms of posttraumatic stress disorder (PTSD) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences."3.77Exploring relations among traumatic, posttraumatic, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Cutter, CJ; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2011)
" Factors associated with recent suicide attempts were: being an RR entrant, female gender, younger age, less education, more extensive polydrug use, benzodiazepine use, recent heroin overdose, Major Depression, current suicidal ideation, Borderline Personality Disorder (BPD)and Post-Traumatic Stress Disorder."3.72Attempted suicide among entrants to three treatment modalities for heroin dependence in the Australian Treatment Outcome Study (ATOS): prevalence and risk factors. ( Darke, S; Lynskey, M; Ross, J; Teesson, M, 2004)
"The occurrence of PTSD-related symptoms was associated with greater drug abuse severity after controlling for gender, depression, and lifetime diagnosis of PTSD."2.70Violent traumatic events and drug abuse severity. ( Clark, HW; Delucchi, KL; Hall, SM; Masson, CL; Sees, KL, 2001)
"Patients with PTSD had higher proportion of chronic pain and high-perceived stress, and lower pain threshold, with similar supra-threshold ratings."1.62Post-traumatic stress disorder due to sexual abuse and its relation to pain sensitivity among patients in methadone maintenance treatment. ( Adelson, M; Lamhoot, T; Peles, E; Sason, A; Schreiber, S, 2021)
"Utility of the session, knowledge of PTSD, and barriers of care were evaluated through a pre- and post- session questionnaire."1.51Integrated Brief Intervention for PTSD and Substance Use in an Antepartum Unit. ( Glance, J; Gopalan, P; Shenai, N, 2019)
"Traumatic events and PTSD symptoms were tested for association with drug use, treatment interruption, and counseling adherence in the same month, one month later, and two months later."1.43Effect of traumatic event reexposure and PTSD on substance use disorder treatment response. ( Brooner, RK; Kidorf, MS; King, VL; Peirce, JM, 2016)
"For women with substance use problems, childhood sexual abuse (CSA), intimate partner violence exposure (IPV), posttraumatic stress disorder (PTSD), and overall psychological distress are often co-occurring concerns."1.38Childhood sexual abuse characteristics, intimate partner violence exposure, and psychological distress among women in methadone treatment. ( El-Bassel, N; Engstrom, M; Gilbert, L, 2012)
"Occurrence of trauma or PTSD did not predict drop-out rates."1.31Posttraumatic stress disorder and short-term outcome in early methadone treatment. ( Fraser, D; Hien, DA; Levin, FR; Nunes, E, 2000)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (33.33)29.6817
2010's9 (60.00)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Lamhoot, T1
Adelson, M2
Sason, A1
Schreiber, S2
Peles, E2
Stock, EM1
Zeber, JE1
McNeal, CJ1
Banchs, JE1
Copeland, LA1
Shenai, N1
Gopalan, P1
Glance, J1
Beitel, M2
Savant, JD1
Cutter, CJ2
Peters, S1
Belisle, N1
Barry, DT2
Seligman, Z1
Bloch, M1
Potik, D1
Schiff, M2
Nacasch, N1
Levit, S2
Katz, N1
Foa, EB1
Peirce, JM1
Brooner, RK1
King, VL1
Kidorf, MS1
Garnet, B1
Joshi, D1
Rosenblum, A1
Schottenfeld, RS1
Cohen-Moreno, R1
Engstrom, M1
El-Bassel, N1
Gilbert, L1
Macleod, AD1
Duffy, SG1
Darke, S2
Ross, J2
Lynskey, M2
Teesson, M2
Ali, R1
Ritter, A1
Cooke, R1
Hien, DA1
Nunes, E1
Levin, FR1
Fraser, D1
Clark, HW1
Masson, CL1
Delucchi, KL1
Hall, SM1
Sees, KL1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluating the Impact of Trauma, Trauma-Focused Therapy Services, and COVID-19 Among Patients in the University of Kentucky SMART Clinic[NCT04760418]21 participants (Actual)Interventional2021-05-26Completed
The Norwegian Addiction, Pain and Trauma Study[NCT04908410]1,500 participants (Anticipated)Observational2021-03-23Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for methadone and Acute Post-Traumatic Stress Disorder

ArticleYear
Prolonged Exposure for Treating PTSD Among Female Methadone Patients Who Were Survivors of Sexual Abuse in Israel.
    Social work in health care, 2015, Volume: 54, Issue:8

    Topics: Adult; Adult Survivors of Child Abuse; Child; Child Abuse, Sexual; Depression; Female; Humans; Implo

2015
Violent traumatic events and drug abuse severity.
    Journal of substance abuse treatment, 2001, Volume: 20, Issue:2

    Topics: Adult; Combined Modality Therapy; Comorbidity; Diagnosis, Dual (Psychiatry); Female; Heroin Dependen

2001

Other Studies

13 other studies available for methadone and Acute Post-Traumatic Stress Disorder

ArticleYear
Post-traumatic stress disorder due to sexual abuse and its relation to pain sensitivity among patients in methadone maintenance treatment.
    Psychiatry research, 2021, Volume: 298

    Topics: Chronic Pain; Humans; Methadone; Pain Threshold; Sex Offenses; Stress Disorders, Post-Traumatic

2021
Psychotropic Pharmacotherapy Associated With QT Prolongation Among Veterans With Posttraumatic Stress Disorder.
    The Annals of pharmacotherapy, 2018, Volume: 52, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Arrhythmias, Cardiac; Buspirone; Female; Humans; Male

2018
Integrated Brief Intervention for PTSD and Substance Use in an Antepartum Unit.
    Maternal and child health journal, 2019, Volume: 23, Issue:5

    Topics: Adaptation, Psychological; Adult; Alcoholism; Benzodiazepines; Buprenorphine; Female; Humans; Matern

2019
Psychopathology and pain correlates of dispositional optimism in methadone-maintained patients.
    The American journal on addictions, 2012, Volume: 21 Suppl 1

    Topics: Adult; Analgesics, Opioid; Attitude; Chronic Pain; Depressive Disorder; Female; Health Status; Human

2012
Psychiatric comorbidity differences between women with history of childhood sexual abuse who are methadone-maintained former opiate addicts and non-addicts.
    Psychiatry research, 2014, Sep-30, Volume: 219, Issue:1

    Topics: Adult; Comorbidity; Dissociative Disorders; Female; Humans; Methadone; Middle Aged; Obsessive-Compul

2014
Effect of traumatic event reexposure and PTSD on substance use disorder treatment response.
    Drug and alcohol dependence, 2016, Jan-01, Volume: 158

    Topics: Adult; Cohort Studies; Counseling; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Me

2016
Exploring relations among traumatic, posttraumatic, and physical pain experiences in methadone-maintained patients.
    The journal of pain, 2011, Volume: 12, Issue:1

    Topics: Adult; Analgesics, Opioid; Cross-Sectional Studies; Female; Humans; Life Change Events; Male; Methad

2011
Childhood sexual abuse, post-traumatic stress disorder, and use of heroin among female clients in Israeli methadone maintenance treatment programs (MMTPS).
    Social work in health care, 2010, Volume: 49, Issue:9

    Topics: Adult; Adult Survivors of Child Abuse; Age Factors; Emigrants and Immigrants; Female; Heroin Depende

2010
Childhood sexual abuse characteristics, intimate partner violence exposure, and psychological distress among women in methadone treatment.
    Journal of substance abuse treatment, 2012, Volume: 43, Issue:3

    Topics: Adult; Child; Child Abuse, Sexual; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Longi

2012
Methadone, morphine and PTSD.
    The Australian and New Zealand journal of psychiatry, 2002, Volume: 36, Issue:6

    Topics: Adult; Analgesics, Opioid; Female; Humans; Methadone; Morphine; Stress Disorders, Post-Traumatic; Su

2002
Attempted suicide among entrants to three treatment modalities for heroin dependence in the Australian Treatment Outcome Study (ATOS): prevalence and risk factors.
    Drug and alcohol dependence, 2004, Jan-07, Volume: 73, Issue:1

    Topics: Adolescent; Adult; Age Factors; Ambulatory Care; Antisocial Personality Disorder; Borderline Persona

2004
The characteristics of heroin users entering treatment: findings from the Australian treatment outcome study (ATOS).
    Drug and alcohol review, 2005, Volume: 24, Issue:5

    Topics: Adult; Australia; Buprenorphine; Comorbidity; Crime; Demography; Depressive Disorder, Major; Diagnos

2005
Posttraumatic stress disorder and short-term outcome in early methadone treatment.
    Journal of substance abuse treatment, 2000, Volume: 19, Issue:1

    Topics: Adult; Analysis of Variance; Cocaine-Related Disorders; Diagnosis, Differential; Diagnosis, Dual (Ps

2000