methadone has been researched along with Acute Pain in 16 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Many individuals receiving methadone maintenance treatment (MMT) for opioid addiction also require treatment for acute or chronic pain, and the presence of pain is known to have a negative impact on patient health and function." | 8.89 | Chronic and acute pain and pain management for patients in methadone maintenance treatment. ( Eyler, EC, 2013) |
| "The intensity of postoperative pain can range from mild to severe." | 7.01 | Treatment of Acute Pain in Patients on Naltrexone: A Narrative Review. ( Cornett, EM; Edinoff, AN; Flanagan, CJ; Jackson, ED; Kaye, AD; Kaye, AM; Pearl, NZ; Sinnathamby, ES; Wenger, DM, 2023) |
| "Methadone is a potent opioid exerting an analgesic effect through N-methyl-D-aspartate receptor antagonism and the inhibition of serotonin and noradrenaline reuptake." | 6.61 | Intraoperative Methadone Reduces Pain and Opioid Consumption in Acute Postoperative Pain: A Systematic Review and Meta-analysis. ( Ashmawi, HA; de Orange, FA; Machado, FC; Vieira, JE, 2019) |
| "Many individuals receiving methadone maintenance treatment (MMT) for opioid addiction also require treatment for acute or chronic pain, and the presence of pain is known to have a negative impact on patient health and function." | 4.89 | Chronic and acute pain and pain management for patients in methadone maintenance treatment. ( Eyler, EC, 2013) |
| " Cases were categorized based on adherence to a dosing strategy and LDI indication, including OUD and acute pain, non-prescribed fentanyl exposure, and transition from methadone." | 4.12 | Development of an intravenous low-dose buprenorphine initiation protocol. ( Bodnar, AR; Jablonski, LA; Stewart, RW, 2022) |
| "The intensity of postoperative pain can range from mild to severe." | 3.01 | Treatment of Acute Pain in Patients on Naltrexone: A Narrative Review. ( Cornett, EM; Edinoff, AN; Flanagan, CJ; Jackson, ED; Kaye, AD; Kaye, AM; Pearl, NZ; Sinnathamby, ES; Wenger, DM, 2023) |
| "Treating acute pain among persons with opioid use disorder (OUD) on opioid agonist therapy (OAT) is complex, and the therapeutic benefits of opioids remain unclear when weighted against their abuse potential and respiratory depressant effects." | 2.72 | Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies. ( Avila-Quintero, VJ; Compton, P; De Aquino, JP; Flores, J; Gómez, O; Hickey, T; Parida, S; Sofuoglu, M, 2021) |
| "Methadone is a potent opioid exerting an analgesic effect through N-methyl-D-aspartate receptor antagonism and the inhibition of serotonin and noradrenaline reuptake." | 2.61 | Intraoperative Methadone Reduces Pain and Opioid Consumption in Acute Postoperative Pain: A Systematic Review and Meta-analysis. ( Ashmawi, HA; de Orange, FA; Machado, FC; Vieira, JE, 2019) |
| "Methadone has been recognized as a unique option for treatment of surgical pain due to its multiple mechanisms of analgesia and its potential to decrease tolerance to other opioids." | 1.48 | Use of Methadone to Reverse Opioid Escalation in a Patient With Surgical Pain. ( Chandler, M; Cunningham, G; Jaffar, M; Webb, T, 2018) |
| "Medication assisted treatment for opioid dependence alters the pain experience." | 1.40 | Co-morbid pain and opioid addiction: long term effect of opioid maintenance on acute pain. ( Gonzalez, G; Wachholtz, A, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (68.75) | 24.3611 |
| 2020's | 5 (31.25) | 2.80 |
| Authors | Studies |
|---|---|
| De Aquino, JP | 1 |
| Parida, S | 1 |
| Avila-Quintero, VJ | 1 |
| Flores, J | 1 |
| Compton, P | 2 |
| Hickey, T | 1 |
| Gómez, O | 1 |
| Sofuoglu, M | 1 |
| Smith, K | 1 |
| Wang, M | 1 |
| Abdukalikov, R | 1 |
| McAullife, A | 1 |
| Whitesell, D | 1 |
| Richard, J | 1 |
| Sauer, W | 1 |
| Quaye, A | 1 |
| Jablonski, LA | 1 |
| Bodnar, AR | 1 |
| Stewart, RW | 1 |
| Edinoff, AN | 1 |
| Flanagan, CJ | 1 |
| Sinnathamby, ES | 1 |
| Pearl, NZ | 1 |
| Jackson, ED | 1 |
| Wenger, DM | 1 |
| Cornett, EM | 1 |
| Kaye, AM | 1 |
| Kaye, AD | 1 |
| Murphy, GS | 1 |
| Wu, CL | 1 |
| Mascha, EJ | 1 |
| Machado, FC | 1 |
| Vieira, JE | 1 |
| de Orange, FA | 1 |
| Ashmawi, HA | 1 |
| Rajput, K | 1 |
| Vadivelu, N | 1 |
| Rindom, H | 1 |
| Højsted, J | 1 |
| Brünés, N | 1 |
| Jaffar, M | 1 |
| Cunningham, G | 1 |
| Chandler, M | 1 |
| Webb, T | 1 |
| Webster, LR | 1 |
| Wachholtz, A | 1 |
| Gonzalez, G | 1 |
| Zinck, L | 1 |
| Sonne, NM | 1 |
| Madsen, SL | 1 |
| Nikolajsen, L | 1 |
| Redmond, J | 1 |
| Donroe, JH | 1 |
| Holt, SR | 1 |
| Tetrault, JM | 1 |
| Eyler, EC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Opioid Taper on Opioid-Induced Hyperalgesia[NCT03063905] | 15 participants (Actual) | Observational | 2017-01-31 | Terminated (stopped due to funding expired) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for methadone and Acute Pain
| Article | Year |
|---|---|
Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies.
Topics: Acute Pain; Analgesia; Analgesics, Opioid; Buprenorphine; Female; Humans; Male; Methadone; Opiate Su | 2021 |
Pain Management Considerations in Patients With Opioid Use Disorder Requiring Critical Care.
Topics: Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Critical Care; Humans; Meth | 2022 |
Treatment of Acute Pain in Patients on Naltrexone: A Narrative Review.
Topics: Acute Pain; Analgesics, Opioid; Buprenorphine; Humans; Methadone; Naltrexone; Opiate Substitution Tr | 2023 |
Intraoperative Methadone Reduces Pain and Opioid Consumption in Acute Postoperative Pain: A Systematic Review and Meta-analysis.
Topics: Acute Pain; Analgesics, Opioid; Clinical Trials as Topic; Humans; Intraoperative Care; Methadone; Pa | 2019 |
Acute Pain Management of Chronic Pain Patients in Ambulatory Surgery Centers.
Topics: Acute Pain; Analgesics, Opioid; Anesthesia, Conduction; Buprenorphine, Naloxone Drug Combination; Ch | 2021 |
[Treatment of acute pain in opioid addicts].
Topics: Acute Pain; Analgesics, Opioid; Buprenorphine; Humans; Methadone; Morphine; Opiate Substitution Trea | 2017 |
[Analgesic management of acute pain in patients receiving methadone or buprenorphine].
Topics: Acute Pain; Analgesics, Opioid; Buprenorphine; Drug Tolerance; Drug Users; Humans; Methadone; Morphi | 2015 |
Caring for patients with opioid use disorder in the hospital.
Topics: Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Dru | 2016 |
Chronic and acute pain and pain management for patients in methadone maintenance treatment.
Topics: Acute Pain; Analgesics; Catastrophization; Chronic Pain; Drug Tolerance; Female; Humans; Methadone; | 2013 |
7 other studies available for methadone and Acute Pain
| Article | Year |
|---|---|
Development of an intravenous low-dose buprenorphine initiation protocol.
Topics: Acute Pain; Analgesics, Opioid; Buprenorphine; Fentanyl; Humans; Methadone; Opiate Substitution Trea | 2022 |
Methadone: New Indications for an Old Drug?
Topics: Acute Pain; Analgesics, Opioid; Humans; Methadone; Pain, Postoperative | 2019 |
Acute Pain Management for Patients Receiving Medication-Assisted Therapy.
Topics: Acute Pain; Adult; Aged; Aged, 80 and over; Analgesics; Buprenorphine; Female; Humans; Male; Methado | 2019 |
Use of Methadone to Reverse Opioid Escalation in a Patient With Surgical Pain.
Topics: Abdominal Pain; Acute Pain; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Toleran | 2018 |
Eight principles for safer opioid prescribing.
Topics: Acute Pain; Analgesics, Opioid; Asthma; Benzodiazepines; Chronic Pain; Delayed-Action Preparations; | 2013 |
Co-morbid pain and opioid addiction: long term effect of opioid maintenance on acute pain.
Topics: Acute Pain; Adult; Analgesics, Opioid; Behavior, Addictive; Buprenorphine; Comorbidity; Female; Huma | 2014 |
Patients with OUD.
Topics: Acute Pain; Analgesics, Opioid; Humans; Methadone; Opioid-Related Disorders; United States | 2016 |