Page last updated: 2024-10-30

methadone and Acute Pain

methadone has been researched along with Acute Pain in 16 studies

Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.

Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.

Research Excerpts

ExcerptRelevanceReference
"Many individuals receiving methadone maintenance treatment (MMT) for opioid addiction also require treatment for acute or chronic pain, and the presence of pain is known to have a negative impact on patient health and function."8.89Chronic and acute pain and pain management for patients in methadone maintenance treatment. ( Eyler, EC, 2013)
"The intensity of postoperative pain can range from mild to severe."7.01Treatment of Acute Pain in Patients on Naltrexone: A Narrative Review. ( Cornett, EM; Edinoff, AN; Flanagan, CJ; Jackson, ED; Kaye, AD; Kaye, AM; Pearl, NZ; Sinnathamby, ES; Wenger, DM, 2023)
"Methadone is a potent opioid exerting an analgesic effect through N-methyl-D-aspartate receptor antagonism and the inhibition of serotonin and noradrenaline reuptake."6.61Intraoperative Methadone Reduces Pain and Opioid Consumption in Acute Postoperative Pain: A Systematic Review and Meta-analysis. ( Ashmawi, HA; de Orange, FA; Machado, FC; Vieira, JE, 2019)
"Many individuals receiving methadone maintenance treatment (MMT) for opioid addiction also require treatment for acute or chronic pain, and the presence of pain is known to have a negative impact on patient health and function."4.89Chronic and acute pain and pain management for patients in methadone maintenance treatment. ( Eyler, EC, 2013)
" Cases were categorized based on adherence to a dosing strategy and LDI indication, including OUD and acute pain, non-prescribed fentanyl exposure, and transition from methadone."4.12Development of an intravenous low-dose buprenorphine initiation protocol. ( Bodnar, AR; Jablonski, LA; Stewart, RW, 2022)
"The intensity of postoperative pain can range from mild to severe."3.01Treatment of Acute Pain in Patients on Naltrexone: A Narrative Review. ( Cornett, EM; Edinoff, AN; Flanagan, CJ; Jackson, ED; Kaye, AD; Kaye, AM; Pearl, NZ; Sinnathamby, ES; Wenger, DM, 2023)
"Treating acute pain among persons with opioid use disorder (OUD) on opioid agonist therapy (OAT) is complex, and the therapeutic benefits of opioids remain unclear when weighted against their abuse potential and respiratory depressant effects."2.72Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies. ( Avila-Quintero, VJ; Compton, P; De Aquino, JP; Flores, J; Gómez, O; Hickey, T; Parida, S; Sofuoglu, M, 2021)
"Methadone is a potent opioid exerting an analgesic effect through N-methyl-D-aspartate receptor antagonism and the inhibition of serotonin and noradrenaline reuptake."2.61Intraoperative Methadone Reduces Pain and Opioid Consumption in Acute Postoperative Pain: A Systematic Review and Meta-analysis. ( Ashmawi, HA; de Orange, FA; Machado, FC; Vieira, JE, 2019)
"Methadone has been recognized as a unique option for treatment of surgical pain due to its multiple mechanisms of analgesia and its potential to decrease tolerance to other opioids."1.48Use of Methadone to Reverse Opioid Escalation in a Patient With Surgical Pain. ( Chandler, M; Cunningham, G; Jaffar, M; Webb, T, 2018)
"Medication assisted treatment for opioid dependence alters the pain experience."1.40Co-morbid pain and opioid addiction: long term effect of opioid maintenance on acute pain. ( Gonzalez, G; Wachholtz, A, 2014)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's11 (68.75)24.3611
2020's5 (31.25)2.80

Authors

AuthorsStudies
De Aquino, JP1
Parida, S1
Avila-Quintero, VJ1
Flores, J1
Compton, P2
Hickey, T1
Gómez, O1
Sofuoglu, M1
Smith, K1
Wang, M1
Abdukalikov, R1
McAullife, A1
Whitesell, D1
Richard, J1
Sauer, W1
Quaye, A1
Jablonski, LA1
Bodnar, AR1
Stewart, RW1
Edinoff, AN1
Flanagan, CJ1
Sinnathamby, ES1
Pearl, NZ1
Jackson, ED1
Wenger, DM1
Cornett, EM1
Kaye, AM1
Kaye, AD1
Murphy, GS1
Wu, CL1
Mascha, EJ1
Machado, FC1
Vieira, JE1
de Orange, FA1
Ashmawi, HA1
Rajput, K1
Vadivelu, N1
Rindom, H1
Højsted, J1
Brünés, N1
Jaffar, M1
Cunningham, G1
Chandler, M1
Webb, T1
Webster, LR1
Wachholtz, A1
Gonzalez, G1
Zinck, L1
Sonne, NM1
Madsen, SL1
Nikolajsen, L1
Redmond, J1
Donroe, JH1
Holt, SR1
Tetrault, JM1
Eyler, EC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effects of Opioid Taper on Opioid-Induced Hyperalgesia[NCT03063905]15 participants (Actual)Observational2017-01-31Terminated (stopped due to funding expired)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for methadone and Acute Pain

ArticleYear
Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies.
    Drug and alcohol dependence, 2021, 11-01, Volume: 228

    Topics: Acute Pain; Analgesia; Analgesics, Opioid; Buprenorphine; Female; Humans; Male; Methadone; Opiate Su

2021
Pain Management Considerations in Patients With Opioid Use Disorder Requiring Critical Care.
    Journal of clinical pharmacology, 2022, Volume: 62, Issue:4

    Topics: Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Critical Care; Humans; Meth

2022
Treatment of Acute Pain in Patients on Naltrexone: A Narrative Review.
    Current pain and headache reports, 2023, Volume: 27, Issue:7

    Topics: Acute Pain; Analgesics, Opioid; Buprenorphine; Humans; Methadone; Naltrexone; Opiate Substitution Tr

2023
Intraoperative Methadone Reduces Pain and Opioid Consumption in Acute Postoperative Pain: A Systematic Review and Meta-analysis.
    Anesthesia and analgesia, 2019, Volume: 129, Issue:6

    Topics: Acute Pain; Analgesics, Opioid; Clinical Trials as Topic; Humans; Intraoperative Care; Methadone; Pa

2019
Acute Pain Management of Chronic Pain Patients in Ambulatory Surgery Centers.
    Current pain and headache reports, 2021, Jan-14, Volume: 25, Issue:1

    Topics: Acute Pain; Analgesics, Opioid; Anesthesia, Conduction; Buprenorphine, Naloxone Drug Combination; Ch

2021
[Treatment of acute pain in opioid addicts].
    Ugeskrift for laeger, 2017, Jun-26, Volume: 179, Issue:26

    Topics: Acute Pain; Analgesics, Opioid; Buprenorphine; Humans; Methadone; Morphine; Opiate Substitution Trea

2017
[Analgesic management of acute pain in patients receiving methadone or buprenorphine].
    Ugeskrift for laeger, 2015, Mar-02, Volume: 177, Issue:10

    Topics: Acute Pain; Analgesics, Opioid; Buprenorphine; Drug Tolerance; Drug Users; Humans; Methadone; Morphi

2015
Caring for patients with opioid use disorder in the hospital.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2016, Dec-06, Volume: 188, Issue:17-18

    Topics: Acute Pain; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Dru

2016
Chronic and acute pain and pain management for patients in methadone maintenance treatment.
    The American journal on addictions, 2013, Volume: 22, Issue:1

    Topics: Acute Pain; Analgesics; Catastrophization; Chronic Pain; Drug Tolerance; Female; Humans; Methadone;

2013

Other Studies

7 other studies available for methadone and Acute Pain

ArticleYear
Development of an intravenous low-dose buprenorphine initiation protocol.
    Drug and alcohol dependence, 2022, 08-01, Volume: 237

    Topics: Acute Pain; Analgesics, Opioid; Buprenorphine; Fentanyl; Humans; Methadone; Opiate Substitution Trea

2022
Methadone: New Indications for an Old Drug?
    Anesthesia and analgesia, 2019, Volume: 129, Issue:6

    Topics: Acute Pain; Analgesics, Opioid; Humans; Methadone; Pain, Postoperative

2019
Acute Pain Management for Patients Receiving Medication-Assisted Therapy.
    AACN advanced critical care, 2019, Dec-15, Volume: 30, Issue:4

    Topics: Acute Pain; Adult; Aged; Aged, 80 and over; Analgesics; Buprenorphine; Female; Humans; Male; Methado

2019
Use of Methadone to Reverse Opioid Escalation in a Patient With Surgical Pain.
    Journal of pain & palliative care pharmacotherapy, 2018, Volume: 32, Issue:1

    Topics: Abdominal Pain; Acute Pain; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Toleran

2018
Eight principles for safer opioid prescribing.
    Pain medicine (Malden, Mass.), 2013, Volume: 14, Issue:7

    Topics: Acute Pain; Analgesics, Opioid; Asthma; Benzodiazepines; Chronic Pain; Delayed-Action Preparations;

2013
Co-morbid pain and opioid addiction: long term effect of opioid maintenance on acute pain.
    Drug and alcohol dependence, 2014, Dec-01, Volume: 145

    Topics: Acute Pain; Adult; Analgesics, Opioid; Behavior, Addictive; Buprenorphine; Comorbidity; Female; Huma

2014
Patients with OUD.
    The American journal of nursing, 2016, Volume: 116, Issue:7

    Topics: Acute Pain; Analgesics, Opioid; Humans; Methadone; Opioid-Related Disorders; United States

2016