methadone has been researched along with Acute Liver Injury, Drug-Induced in 16 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Among 42 active heroin users or former heroin addicts maintained on methadone, 79% were heavy alcohol abusers." | 3.65 | The spectrum and causes of liver diseases in narcotic addicts. ( Gelb, AM; Mildvan, D; Stenger, RJ, 1977) |
| "Immediate attention must be given to the respiratory system of the heroin abuser; then he should be given naloxone HCl." | 3.65 | Treating heroin overdose. ( Calabro, JJ; Neaderthal, RL, 1975) |
| "Etravirine (ETR) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with a potent and broad in vitro spectrum of activity against HIV-1 and viruses with NNRTI resistances, allowing sequential use of drugs of this family." | 2.45 | [Etravirine in first-line therapy]. ( Garcés, PA; Tena, EV, 2009) |
| "Methadone 45 mg per day was effective in alleviating his pain, but he experienced severe drowsiness following trabectedin induced liver injury." | 1.51 | [A Case of Methadone Induced Drowsiness Following Trabectedin Induced Liver Injury]. ( Higuchi, M; Ishiki, H; Kiuchi, D; Satomi, E; Shimizu, M, 2019) |
| "Several sessions at the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) described interactions, toxicities, and dosing options of new anti-HIV drugs." | 1.30 | New anti-HIV drug interactions, toxicities, and dosing options. ( Bartnof, HS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (43.75) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Shimizu, M | 1 |
| Higuchi, M | 1 |
| Ishiki, H | 1 |
| Kiuchi, D | 1 |
| Satomi, E | 1 |
| Soyka, M | 1 |
| Garcés, PA | 1 |
| Tena, EV | 1 |
| Saxon, AJ | 1 |
| Ling, W | 1 |
| Hillhouse, M | 1 |
| Thomas, C | 1 |
| Hasson, A | 1 |
| Ang, A | 1 |
| Doraimani, G | 1 |
| Tasissa, G | 1 |
| Lokhnygina, Y | 1 |
| Leimberger, J | 1 |
| Bruce, RD | 1 |
| McCarthy, J | 1 |
| Wiest, K | 1 |
| McLaughlin, P | 1 |
| Bilangi, R | 1 |
| Cohen, A | 1 |
| Woody, G | 1 |
| Jacobs, P | 1 |
| GAENSLER, EA | 1 |
| McGOWAN, JM | 1 |
| Bartnof, HS | 1 |
| Bartoloni Saint Omer, F | 1 |
| Montalto, B | 1 |
| Chibaro, G | 1 |
| Manfredini, F | 1 |
| Gelb, AM | 1 |
| Mildvan, D | 1 |
| Stenger, RJ | 1 |
| Neaderthal, RL | 1 |
| Calabro, JJ | 1 |
| Drummer, OH | 1 |
| Opeskin, K | 1 |
| Syrjanen, M | 1 |
| Cordner, SM | 1 |
| Thornton, WE | 2 |
| Thornton, BP | 2 |
| Lapierre, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Starting Treatment With Agonist Replacement Therapies (START)[NCT00315341] | Phase 4 | 1,269 participants (Actual) | Interventional | 2006-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Participants were categorized according liver transaminase (ALT, AST) levels in blood comparing the baseline sample to any and all subsequent samples in the following manner:~A: both ALT and AST started at less than or equal to two times the ULN and remained at two times or less ULN throughout the study~B: either ALT or AST started at less than or equal to 2 x ULN and at any point in study exceeded 2 x ULN~C: Either ALT or AST started > 2 x ULN, decreased (both ALT and AST) to < 2 x ULN, and remained < 2 x ULN~D: Either ALT or AST started > 2 x ULN and remained above 2 x ULN throughout the study" (NCT00315341)
Timeframe: 24 Weeks
| Intervention | participants (Number) | |||||||
|---|---|---|---|---|---|---|---|---|
| ALT - A (low, stays low) | ALT - B (low, goes high) | ALT - C (high, goes low, stays low) | ALT - D (high, stays high) | AST - A (low, stay low) | AST - B (low, goes high) | AST - C (high, goes low, stays low) | AST - D (high, stays high) | |
| Buprenorphine/Nx | 278 | 41 | 4 | 17 | 291 | 37 | 3 | 9 |
| Methadone | 318 | 62 | 1 | 10 | 328 | 54 | 1 | 8 |
4 reviews available for methadone and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Alcohol use disorders in opioid maintenance therapy: prevalence, clinical correlates and treatment.
Topics: Alcohol Drinking; Alcohol-Related Disorders; Brain; Buprenorphine; Chemical and Drug Induced Liver I | 2015 |
[Etravirine in first-line therapy].
Topics: Anti-HIV Agents; Chemical and Drug Induced Liver Injury; Drug Eruptions; Drug Interactions; Drug Res | 2009 |
Narcotic poisoning: a review of the literature.
Topics: Chemical and Drug Induced Liver Injury; Drug Contamination; Endocarditis; Heroin Dependence; Humans; | 1974 |
1 trial available for methadone and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Buprenorphine/Naloxone and methadone effects on laboratory indices of liver health: a randomized trial.
Topics: Adolescent; Adult; Buprenorphine; Chemical and Drug Induced Liver Injury; Drug Combinations; Female; | 2013 |
11 other studies available for methadone and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
[A Case of Methadone Induced Drowsiness Following Trabectedin Induced Liver Injury].
Topics: Aged; Chemical and Drug Induced Liver Injury; Histiocytoma, Malignant Fibrous; Humans; Liver; Male; | 2019 |
Biliary and small intestinal spasm due to synthetic analgesics methadone and methyldihydromorphinone (metopon).
Topics: Analgesics; Biliary Tract; Chemical and Drug Induced Liver Injury; Humans; Intestines; Liver; Methad | 1950 |
New anti-HIV drug interactions, toxicities, and dosing options.
Topics: Anti-HIV Agents; Antidepressive Agents; Chemical and Drug Induced Liver Injury; Clinical Trials as T | 1999 |
[Hepatic histopathological aspects and humoral findings in drug addicts: critical considerations on 37 cases].
Topics: Adolescent; Adult; Alanine Transaminase; Alcoholism; Amphetamines; Aspartate Aminotransferases; Benz | 1979 |
The spectrum and causes of liver diseases in narcotic addicts.
Topics: Acute Disease; Alcoholism; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Chronic Disease; | 1977 |
Treating heroin overdose.
Topics: Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Emer | 1975 |
Methadone toxicity causing death in ten subjects starting on a methadone maintenance program.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Female; Half-Life; Hero | 1992 |
Adverse reactions to heroin use.
Topics: Abscess; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Chromosomes; Endocarditis; Femal | 1974 |
Possible hepatotoxic effect of methadone.
Topics: Chemical and Drug Induced Liver Injury; Hematopoiesis; Humans; Infectious Mononucleosis; Male; Metha | 1969 |