methadone and Ache
methadone has been researched along with Ache in 480 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pain in opioid-dependent patients is common but data measuring the course of pain (and its correlates) using validated scales in patients initiating methadone treatment are sparse." | 9.24 | Pain in methadone patients: Time to address undertreatment and suicide risk (ANRS-Methaville trial). ( Bendiane, MK; Carrieri, P; Lions, C; Maradan, G; Michel, L; Mora, M; Morel, A; Nordmann, S; Roux, P; Spire, B; Vilotitch, A, 2017) |
| "This analysis explored the prevalence and correlates of pain in patients enrolled in methadone maintenance treatment (MMT)." | 9.17 | Epidemiology of pain among outpatients in methadone maintenance treatment programs. ( Dhingra, L; Homel, P; Jordan, AE; Katz, J; Masson, C; McKnight, C; Perlman, DC; Portenoy, RK; Seewald, RM; Wald, E; Young, C, 2013) |
| "This study was designed to evaluate the role of epidural methadone-lidocaine in cancer pain combined or not to epidural dexamethasone." | 9.17 | Epidural methadone results in dose-dependent analgesia in cancer pain, further enhanced by epidural dexamethasone. ( Lauretti, GR; Mattos, AL; Rizzo, CC; Rodrigues, SW, 2013) |
| "The objective of the study was to describe the experience of methadone use in 100 consecutive chronic pain patients managed in a single multidisciplinary center." | 9.13 | Experience of methadone therapy in 100 consecutive chronic pain patients in a multidisciplinary pain center. ( Evans, D; Galonski, M; Gordon, A; Gourlay, D; Peng, P; Stafford, M; Tumber, P; Wong, P, 2008) |
| "To compare the effectiveness and side effects of methadone and morphine as first-line treatment with opioids for cancer pain." | 9.11 | Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study. ( Bertolino, M; Bosnjak, S; Bruera, E; Fisch, MJ; Mathias, C; Moyano, J; Palmer, JL; Rico, MA; Spruyt, O; Strasser, F; Sweeney, C; Willey, J, 2004) |
| "Methadone is effective for chronic cancer pain, but its early pharmacodynamic profile and effectiveness for breakthrough pain remain uncertain." | 9.11 | Characterization of the early pharmacodynamic profile of oral methadone for cancer-related breakthrough pain: a pilot study. ( Fisher, K; Hagen, NA; Stiles, C, 2004) |
| "The aim of this study is to characterize patients with chronic pain in methadone maintenance treatment (MMT)." | 9.11 | Significantly higher methadone dose for methadone maintenance treatment (MMT) patients with chronic pain. ( Adelson, M; Gordon, J; Peles, E; Schreiber, S, 2005) |
| "Methadone is a strong opioid analgesic that has been used successfully in cancer pain management." | 9.11 | Intermittent subcutaneous methadone administration in the management of cancer pain. ( Centeno, C; Vara, F, 2005) |
| "This prospective study documents the use of methadone as part of an opioid rotation strategy in patients with uncontrolled pain and severe delirium admitted for terminal care to a tertiary cancer palliative care hospital." | 9.11 | Methadone in the treatment of pain and terminal delirum in advanced cancer patients. ( Comfort, C; Kogan, M; Moryl, N; Obbens, E, 2005) |
| "The successful use of methadone in cancer pain has been supported by numerous case reports and clinical studies." | 9.10 | Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain. ( Derby, S; Fischberg, D; Kornick, C; Manfredi, PL; Moryl, N; Payne, R; Santiago-Palma, J, 2002) |
| "To assess the use of methadone in patients with cancer pain who fail to respond to increasing doses of other opioids or experience intolerable side-effects from them." | 9.09 | Methadone titration in opioid-resistant cancer pain. ( Gonty, N; Scholes, CF; Trotman, IF, 1999) |
| "The use of methadone in the treatment of cancer pain is becoming more attractive mainly because of its known efficacy, lack of active metabolites, and low cost." | 9.09 | Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain. ( Bruera, E; Gagnon, B, 1999) |
| "In a prospective, open study, 37 advanced cancer patients in poor pain control receiving high doses of subcutaneous hydromorphone (mean daily dose: 276 +/- 163 mg) were switched to methadone by use of custom-made capsules (21 patients) or suppositories (16 patients)." | 9.08 | Custom-made capsules and suppositories of methadone for patients on high-dose opioids for cancer pain. ( Bruera, E; Fainsinger, RL; Inturrisi, C; Spachynski, K; Suarez-Almazor, M; Watanabe, S, 1995) |
| "Methadone is a very useful drug in cancer pain because of its low cost, lack of active metabolites, high oral availability, and the rapid onset of its analgesic effect." | 9.08 | Patient-controlled analgesia with oral methadone in cancer pain: preliminary report. ( Caligara, M; Mercadante, S; Sapio, M; Serretta, R, 1996) |
| "To determine the relationship between changes in plasma methadone concentration and pharmacodynamic effects, plasma methadone profiles and pharmacodynamics (analgesia and sedation) were measured during and after the continuous infusion of methadone for 180 to 270 minutes in 15 patients with pain caused by cancer." | 9.06 | Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain. ( Colburn, WA; Foley, KM; Inturrisi, CE; Max, MB; Portenoy, RK, 1990) |
| "Eighteen patients suffering from cancer were entered into a study of the pharmacokinetics and efficacy of methadone and morphine in pain control." | 9.06 | A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer. ( Cherry, DA; Cousins, MJ; Gourlay, GK, 1986) |
| "This study reports the results of a double-blind, parallel-group comparison of intravenous methadone with morphine for the control of postoperative pain." | 9.06 | A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control. ( Gourlay, GK; Lamberty, J; Willis, RJ, 1986) |
| "Methadone, due to its multimechanistic action profile, is possibly among the most effective and most underutilized opioid analgesics in children with severe unrelieved pain at end of life." | 9.01 | From Tramadol to Methadone: Opioids in the Treatment of Pain and Dyspnea in Pediatric Palliative Care. ( Friedrichsdorf, SJ, 2019) |
| "Methadone is a valuable opioid in the management of patients who have cancer with pain." | 8.98 | Methadone: Maximizing Safety and Efficacy for Pain Control in Patients with Cancer. ( Costantino, RC; McPherson, AL; McPherson, ML, 2018) |
| "To determine the effectiveness and tolerability of methadone as an analgesic in adults and children with cancer pain." | 8.95 | Methadone for cancer pain. ( Derry, S; Nicholson, AB; Watson, GR; Wiffen, PJ, 2017) |
| "The proven therapeutic efficacy of methadone in cancer pain is hindered by a challenging pharmacokinetic-pharmacodynamic profile, considerable interpatient variation, and increasing concern about the complexities of dosing." | 8.90 | Therapeutic challenges in cancer pain management: a systematic review of methadone. ( Afsharimani, B; Good, P; Hardy, J; Haywood, A; Khan, S; Movva, R, 2014) |
| "To determine the analgesic efficacy of transdermal fentanyl for relief of cancer pain, and to assess the adverse events associated with the use of transdermal fentanyl for relief of cancer pain." | 8.89 | Transdermal fentanyl for cancer pain. ( Derry, S; Hadley, G; Moore, RA; Wiffen, PJ, 2013) |
| "Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain." | 8.86 | Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010) |
| "Methadone is increasingly prescribed for chronic pain, yet the associated mortality appears to be rising disproportionately relative to other opioid analgesics." | 8.85 | Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation. ( Andrews, CM; Capacchione, JF; Haigney, MC; Krantz, MJ; Marcuson, MJ; Wedam, EF, 2009) |
| "To outline pharmacodynamics, pharmacokinetics, drug interactions, equianalgesic dose ratio with other opioids, dosing rules, adverse effects and methadone clinical studies in patients with cancer pain." | 8.85 | The role of methadone in cancer pain treatment--a review. ( Leppert, W, 2009) |
| "Methadone is an opioid used in the management of cancer pain." | 8.84 | Methadone for cancer pain. ( Nicholson, AB, 2007) |
| "This topical review addresses methadone's pharmacology, its application in malignant and non-malignant pain conditions, practical issues related to methadone for the treatment of pain and its influence on QTc time." | 8.84 | Clinical pharmacology of methadone for pain. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Moksnes, K, 2008) |
| "Once used only as third-line therapy for chronic pain management, methadone is now being used as first- and second-line therapy in palliative care." | 8.84 | Consensus guideline on parenteral methadone use in pain and palliative care. ( Berger, A; Blinderman, CD; Bruera, E; Davis, MP; Derby, S; Inturrisi, C; Kalman, J; Mehta, D; Pappagallo, M; Perlov, E; Shaiova, L, 2008) |
| "Methadone is an opioid used in the management of cancer pain both in opioid naïve patients and in rotation from other opioids." | 8.82 | Methadone for cancer pain. ( Nicholson, AB, 2004) |
| "This article reviews the unique pharmacological properties of methadone and outlines its appropriate clinical application, with focus upon its use in the treatment of chronic pain." | 8.82 | Methadone: applied pharmacology and use as adjunctive treatment in chronic pain. ( Brown, R; Fleming, M; Kraus, C; Reddy, S, 2004) |
| "Methadone, although having been available for approximately half a century, is now receiving increasing attention in the management of chronic pain." | 8.82 | A review of the use of methadone for the treatment of chronic noncancer pain. ( Lynch, ME, 2005) |
| " Several studies have demonstrated that methadone is a valid alternative to morphine, hydromorphone, and fentanyl for the treatment of cancer-related pain, and extensive reviews on the subject have been published in recent years [10,23,25,64,70,71]." | 8.81 | The use of methadone for cancer pain. ( Bianchi, M; Ripamonti, C, 2002) |
| "Methadone, a synthetic opioid, has unique pharmacodynamics and pharmacokinetics, which contribute to its unique ability to relieve pain unresponsive to other potent opiates and its unique dosing and drug interactions." | 8.81 | Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration. ( Davis, MP; Walsh, D, 2001) |
| "In recent years a better understanding of the pharmacologic and pharmacokinetic properties of methadone, including equianalgesic ratios has led to its increased use as a second line opioid for the treatment of pain in patients with cancer." | 8.81 | Methadone use in cancer patients with pain: a review. ( Bruera, E; Sweeney, C, 2002) |
| " While these agents have clinical utility supported by robust literature, we the authors posit that buprenorphine is a superior therapy for both opioid use disorder (OUD) as well as pain." | 8.02 | A history of opioid abuse: Why buprenorphine is superior for the management of opioid use disorder and pain. ( Komrowski, MD; Sekhri, NK, 2021) |
| "One-hundred-and-sixty-four patients receiving methadone maintenance treatment completed a battery of self-report measures related to alexithymia, drug use, and pain experiences." | 8.02 | Alexithymia and pain experience among patients using methadone-maintenance therapy. ( Barry, DT; Beitel, M; Gaeta, M; Morie, KP; Oberleitner, DE; Oberleitner, LM; Potenza, MN; Roos, CR; Yip, SW, 2021) |
| "Many factors make methadone an appealing option for treatment of pain in patients seen by palliative care; however, complex drug-related properties and variable patient response complicate appropriate conversion ratios from other opioids to methadone." | 7.85 | Methadone Dose Selection for Treatment of Pain Compared with Consensus Recommendations. ( Ajayi, TA; Atayee, RS; Edmonds, KP; Karimian, P, 2017) |
| "To date there have been no studies investigating the characteristics of pain in Chinese heroin-dependent patients (HDPs) receiving methadone maintenance treatment (MMT)." | 7.85 | Prevalence of pain and its socio-demographic and clinical correlates among heroin-dependent patients receiving methadone maintenance treatment. ( Chen, WC; Lu, J; Xu, YM; Yang, YJ; Zhong, BL; Zhu, JH, 2017) |
| "Use of the prescription opioid methadone for treatment of pain, as opposed to treatment of opioid use disorder (e." | 7.83 | Trends in Methadone Distribution for Pain Treatment, Methadone Diversion, and Overdose Deaths - United States, 2002-2014. ( Baldwin, GT; Jones, CM; Mack, KA; Manocchio, T; White, JO, 2016) |
| "The use of very-low-dose methadone in conjunction with haloperidol in the acute-care setting resulted in improved pain control after conversion from typical opiates." | 7.81 | The use of very-low-dose methadone and haloperidol for pain control in the hospital setting: a preliminary report. ( Bruera, E; Buckley, JS; Buckley, NS; Salpeter, SR, 2015) |
| "There are few studies that describe cardiac adverse events in patients prescribed methadone for pain management." | 7.80 | Methadone for pain and the risk of adverse cardiac outcomes. ( Delate, T; Kurz, D; Price, LC; Shanahan, R; Wobeter, B, 2014) |
| "Previous research has reported improved pain after adding methadone to another opioid, but did not quantify this benefit using a validated outcome measure." | 7.79 | Addition of methadone to another opioid in the management of moderate to severe cancer pain: a case series. ( Bryson, J; Mak, E; Ridley, J; Wallace, E; Zimmermann, C, 2013) |
| "The success of rehabilitation is not influenced solely by drug abstinence, but also by the state of general health and well-being, which for patients in methadone maintenance treatment (MMT) frequently is compromised by experiencing pain, depression and sleep disorders." | 7.78 | Pain depression and sleep disorders among methadone maintenance treatment patients. ( Lawental, E; Pud, D; Zlotnick, C, 2012) |
| "Vital statistics data suggest that the opioid pain reliever (OPR) methadone is involved in one third of OPR-related overdose deaths, but it accounts for only a few percent of OPR prescriptions." | 7.78 | Vital signs: risk for overdose from methadone used for pain relief - United States, 1999-2010. ( , 2012) |
| "The reports on pain perception among former heroin addicts receiving methadone maintenance treatment (MMT) vary with regard to pain and intolerance threshold, and perception of suprathreshold stimuli has not been previously evaluated." | 7.77 | The differential effect of methadone dose and of chronic pain on pain perception of former heroin addicts receiving methadone maintenance treatment. ( Adelson, M; Defrin, R; Hetzroni, T; Peles, E; Schreiber, S, 2011) |
| "Differences in lifetime trauma exposure and screened symptoms of posttraumatic stress disorder (PTSD) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences." | 7.77 | Exploring relations among traumatic, posttraumatic, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Cutter, CJ; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2011) |
| "The aim of this study was to examine the association of pain catastrophizing and pain coping strategies with characteristic pain intensity (an average of worst, least, and typical pain intensity in the past week) and recent pain-related disability (an average of three measures of past week pain interference) in opioid-dependent patients enrolled in a methadone maintenance treatment program (MMTP) who reported recent pain." | 7.77 | Pain catastrophizing and pain coping among methadone-maintained patients. ( Barry, DT; Beitel, M; Cutter, CJ; Garnet, B; Peters, S; Savant, J; Schottenfeld, RS, 2011) |
| " Our objective was to compare mortality rates among patients who received prescribed methadone or long-acting morphine for pain." | 7.77 | Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain. ( Bair, MJ; Becker, WC; Hui, S; Krebs, EE; McCoy, K; Zerzan, J, 2011) |
| "Methadone is an effective and inexpensive opioid for cancer pain treatment." | 7.76 | Methadone initiation and rotation in the outpatient setting for patients with cancer pain. ( Bruera, E; Calderon, B; de la Cruz, M; El Osta, B; Li, Z; Palmer, JL; Parsons, HA, 2010) |
| "We conducted a feasibility study of sublingual methadone for breakthrough cancer pain, to determine whether a larger, randomized trial was warranted, and to identify a study design that would be likely to succeed." | 7.76 | A formal feasibility study of sublingual methadone for breakthrough cancer pain. ( Biondo, PD; Brasher, PM; Eliasziw, M; Hagen, NA; Moulin, DE; Stiles, CR; Watanabe, SM, 2010) |
| "Methadone is an excellent choice for pain in frail older adults." | 7.75 | Methadone: an effective, safe drug of first choice for pain management in frail older adults. ( Gallagher, R, 2009) |
| "Following the findings of perceived poor sleep and of chronic pain among former heroin addicts, current methadone maintenance treatment (MMT) patients, and its possible relation to methadone dose, we studied these patients' objective sleep parameters." | 7.75 | Documented poor sleep among methadone-maintained patients is associated with chronic pain and benzodiazepine abuse, but not with methadone dose. ( Adelson, M; Peles, E; Schreiber, S, 2009) |
| "Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients." | 7.75 | Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009) |
| "Differences in psychiatric distress and substance use (licit and illicit) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences." | 7.75 | Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2009) |
| "Methadone maintained treatment (MMT) patients may be given less opioid analgesia for acute pain than the general patient, due to requests for analgesia being misinterpreted as craving for drugs." | 7.74 | Management of acute pain in methadone maintenance therapy in-patients. ( Curry, K; Fong, D; Hines, S; Theodorou, S; Williamson, A, 2008) |
| "The use of methadone may be difficult and its use in the treatment of chronic non-malignant pain is only sparsely described in literature, whereas several works have shown the advantage of methadone in the treatment of cancer pain." | 7.74 | [Methadone in the treatment of chronic non-malignant pain]. ( Bendiksen, A; Handberg, G; McGehee, E, 2007) |
| "Methadone treatment in chronic pain patients is still limited owing to misconceptions about addiction, safety, and its unique pharmacokinetic and pharmacodynamic properties." | 7.74 | Nurse case management program of chronic pain patients treated with methadone. ( Lamb, L; Pereira, JX; Shir, Y, 2007) |
| "Iatrogenic opioid addiction among chronic pain patients was the initiative for starting a methadone programme for pain patients at the University Hospital of Uppsala." | 7.73 | Methadone treatment of chronic non-malignant pain and opioid dependence--a long-term follow-up. ( Gordh, T; Grönbladh, L; Nilsson, LH; Rhodin, A, 2006) |
| "Vulnerability to delirium was potentially caused by coadministration of methadone, which can inhibit the CYP2D6 isozyme." | 7.73 | Dextromethorphan-induced delirium and possible methadone interaction. ( Lotrich, FE; Pollock, BG; Rosen, J, 2005) |
| "Both clinicians and researchers have expressed doubt that opiate dependent patients with significant pain can be effectively treated in methadone maintenance treatment (MMT) programs; however, little research exists on this topic." | 7.73 | Response to methadone maintenance treatment of opiate dependent patients with and without significant pain. ( Humphreys, K; Ilgen, MA; Trafton, JA, 2006) |
| "Twelve patients with poor pain control or unacceptable side effects during treatment with morphine were switched to methadone and followed for nine months in this open prospective study." | 7.73 | Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Klepstad, P; Landrø, NI, 2006) |
| "Although studies on the beliefs of persons with chronic nonmalignant pain (CNMP) are still scarce, methadone is increasingly prescribed for the treatment of CNMP." | 7.73 | Response phases in methadone treatment for chronic nonmalignant pain. ( Arnaert, A; Ciccotosto, G, 2006) |
| "Racemic methadone is increasingly used to manage cancer pain." | 7.73 | Pharmacokinetics and pharmacodynamics of methadone enantiomers in hospice patients with cancer pain. ( Auret, K; Boyd, F; Ilett, KF; Oh, TE; Page-Sharp, M; Roger Goucke, C, 2006) |
| "Methadone hydrochloride is an effective, inexpensive, and relatively safe opioid to use in the treatment of patients with chronic pain." | 7.73 | Prescribing methadone for pain management in end-of-life care. ( Manfredonia, JF, 2005) |
| "To estimate the prevalence and to examine the characteristics of chronic severe pain in chemically dependent populations receiving methadone maintenance or inpatient residential treatment." | 7.72 | Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. ( Cleland, C; Fong, C; Joseph, H; Kipnis, S; Portenoy, RK; Rosenblum, A, 2003) |
| "To investigate the relationship between the daily dose of the synthetic opioid methadone and the corrected QT (QTc) interval in a series of methadone-treated patients who developed torsade de pointes." | 7.72 | Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. ( Krantz, MJ; Kutinsky, IB; Mehler, PS; Robertson, AD, 2003) |
| "The objectives of this medico-legal case report were the following: 1) To present an example of a medico-legal problem that developed as a result of a decision to rotate a chronic pain patient (CPP) to methadone in order to taper the CPP from oxycodone; 2) To present both the plaintiff's and defendant's expert witnesses' opinions as to if and where the care of that patient fell below the "standard of medical care;" and 3) Based on these opinions, to develop some recommendations on how, in the future, pain medicine physicians and other physicians should proceed, in order to avoid allegations of breach of "standards of care" when using methadone." | 7.72 | Medico-legal rounds: medico-legal issues and alleged breaches of "standards of medical care" in opioid rotation to methadone: a case report. ( Cole, B; Cutler, RB; Fishbain, DA; Lewis, J; Rosomoff, HL; Rosomoff, RS, 2003) |
| "To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy." | 7.72 | Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004) |
| "Recent studies indicate that severe chronic pain is common among patients in methadone maintenance treatment (MMT), but no qualitative studies have examined such patients' experiences of pain and pain treatment." | 7.72 | The experience of chronic severe pain in patients undergoing methadone maintenance treatment. ( Arnstein, J; Arnsten, JH; Berg, K; Gourevitch, M; Karasz, A; Selwyn, P; Zallman, L, 2004) |
| "To evaluate a series of methadone-treated patients experiencing torsade de pointes." | 7.71 | Torsade de pointes associated with very-high-dose methadone. ( Hays, H; Krantz, MJ; Lewkowiez, L; Mehler, PS; Robertson, AD; Woodroffe, MA, 2002) |
| "An expert working group of the European Association for Palliative Care has revised and updated its guidelines on the use of morphine in the management of cancer pain." | 7.71 | Morphine and alternative opioids in cancer pain: the EAPC recommendations. ( Casas, JR; Cherny, N; Conno, F; Hanks, GW; Hanna, M; Kalso, E; McQuay, HJ; Mercadante, S; Meynadier, J; Poulain, P; Radbruch, L; Ripamonti, C; Sawe, J; Twycross, RG; Ventafridda, V, 2001) |
| "Methadone is still regarded as a second line opioid for patients suffering from severe pain, and is rarely used in hospitalized patients." | 7.71 | Methadone is safe for treating hospitalized patients with severe pain. ( Davidson, EM; Rosen, G; Shir, Y; Zeldin, A, 2001) |
| "In a patient on methadone maintenance treatment, admitted for lung cancer suspicion, a slight decrease in pain dose response to morphine have necessitated adjustments of methadone treatment founded on clinical check-up and methadone assay." | 7.71 | Slow metabolism and long half life of methadone in a patient with lung cancer and cirrhosis. ( Beauverie, P; Edel, YA; Furlan, V, 2001) |
| "Current equianalgesic reference tables, based largely on single dose studies, give dose ratios of 1:1 to 4:1 for oral morphine to oral methadone, which possibly are inaccurate in patients with cancer pain who are exposed to multiple doses of these opioids." | 7.70 | Dose ratio between morphine and methadone in patients with cancer pain: a retrospective study. ( Bruera, ED; Hanson, J; Lawlor, PG; Turner, KS, 1998) |
| "Oral methadone is considered to be a valid opioid analgesic alternative to morphine and hydromorphone in treating cancer pain." | 7.70 | Equianalgesic dose/ratio between methadone and other opioid agonists in cancer pain: comparison of two clinical experiences. ( Belzile, M; Bruera, E; De Conno, F; Groff, L; Hanson, J; Pereira, J; Ripamonti, C, 1998) |
| "To define the dose ratio between morphine and methadone in relation to the previous morphine dose and the number of days needed to achieve the same level of analgesia in a group of patients with advanced cancer with pain who switched from morphine to oral methadone." | 7.70 | Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio? ( Brunelli, C; De Conno, F; Groff, L; Polastri, D; Ripamonti, C; Stavrakis, A, 1998) |
| " In the past 2 years, oral methadone has been used extensively in our institution for treating children with persistent pain from cancer, burns, or trauma who were capable of oral intake and whose pain was not relieved by nonopioid medications." | 7.70 | Oral methadone for the treatment of severe pain in hospitalized children: a report of five cases. ( Davidson, EM; Rosen, G; Shavelson, V; Shenkman, Z; Shir, Y, 1998) |
| "Chronic pain patients who have limited access to opioids may be redirected to methadone maintenance centers for management of their pain." | 7.70 | Characteristics of methadone maintenance patients with chronic pain. ( Jamison, RN; Katz, NP; Kauffman, J, 2000) |
| "We evaluated the analgesia, tolerability and absorption profile of methadone hydrochloride in six opioid-naive cancer patients with pain." | 7.69 | Rectal methadone in cancer patients with pain. A preliminary clinical and pharmacokinetic study. ( Brunelli, C; De Conno, F; Lodi, F; Ripamonti, C; Rizzio, E; Saita, L; Zecca, E, 1995) |
| "Five patients with chronic nonmalignant pain were transferred from other analgesics to oral methadone." | 7.69 | Oral methadone for managing chronic nonmalignant pain. ( Gardner-Nix, JS, 1996) |
| "The aims of this study were to describe the analgesia, side effects, and dosage and the causes of suspension of treatment in a large sample of advanced cancer patients with pain after treatment with oral methadone from 7 to 90 days." | 7.69 | Clinical experience with oral methadone administration in the treatment of pain in 196 advanced cancer patients. ( Brunelli, C; De Conno, F; Groff, L; Ripamonti, C; Ventafridda, V; Zecca, E, 1996) |
| "Methadone is a very effective second-line opioid for treatment of cancer pain." | 7.69 | Intravenous methadone for cancer pain unrelieved by morphine and hydromorphone: clinical observations. ( Borsook, D; Chandler, SW; Manfredi, PL; Payne, R, 1997) |
| "Concentrations of methadone in plasma, estimates of pain relief, and pupillary size were determined after a single intravenous dose (10 to 30 mg) of methadone hydrochloride to eight patients with chronic pain, five of whom had cancer." | 7.67 | Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain. ( Colburn, WA; Foley, KM; Houde, RW; Inturrisi, CE; Kaiko, RF, 1987) |
| "Forty-two cancer patients with pain and/or opioid side effects were assessed in this randomised trial." | 6.77 | Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain. ( Dale, O; Kaasa, S; Moksnes, K; Paulsen, Ø; Rosland, JH; Spigset, O, 2012) |
| "Providing pain management for known opioid abusers is a challenging clinical task, in part because little is known about their pain experience and analgesic requirements." | 6.69 | Pain responses in methadone-maintained opioid abusers. ( Charuvastra, VC; Compton, P; Kintaudi, K; Ling, W, 2000) |
| " The pharmacokinetic parameters of the R- and S-enantiomers of the racemate are reported." | 6.68 | Stereoselective pharmacokinetics of methadone in chronic pain patients. ( Angelo, HR; Blemmer, T; Christrup, LL; Drenck, NE; Kristensen, K; Rasmussen, SN; Sjøgren, P, 1996) |
| "Methadone is a very potent analgesic drug." | 6.68 | Pain perception of intravenous heroin users on maintenance therapy with levomethadone. ( Gastpar, M; Katta, T; Klöppel, A; Pries, E; Schall, U, 1996) |
| " After achieving adequate analgesia with regular dosing of oral methadone (T1), patient-controlled analgesia with methadone was administered for 3 days (T2)." | 6.68 | Opioid-sparing effect of diclofenac in cancer pain. ( Barresi, L; Caligara, M; Dardanoni, G; Mercadante, S; Sapio, M; Serretta, R, 1997) |
| "Up to 44% of patients with cancer-related pain require opioid rotation (OR) because of inadequate analgesia or side effects." | 6.52 | Methods of Rotation From Another Strong Opioid to Methadone for the Management of Cancer Pain: A Systematic Review of the Available Evidence. ( McLean, S; Twomey, F, 2015) |
| "Methadone was used subcutaneously as an analgesic agent in 1 patient." | 6.47 | Review of cancer pain management in patients receiving maintenance methadone therapy. ( McLean, S; McQuillan, R; O'Gorman, A; Rowley, D; Ryan, K, 2011) |
| "Methadone is a synthetic opioid with potent analgesic effects." | 6.43 | Methadone treatment for pain states. ( Kral, LA; Toombs, JD, 2005) |
| "Undertreatment of acute pain is suboptimal medical treatment, and patients receiving long-term OAT are at particular risk." | 6.43 | Acute pain management for patients receiving maintenance methadone or buprenorphine therapy. ( Alford, DP; Compton, P; Samet, JH, 2006) |
| "Ongoing assessment, multiple approaches, and excellent communication among all care management team members are critical." | 6.43 | Difficult cases in pain management: use of methadone in a multifactorial approach. ( Coyle, N; Coyne, P; Griffie, J, 2006) |
| "Methadone is a unique mu opioid agonist, which also has delta receptor affinity and properties of N-methyl-D-aspartate receptor antagonism and monoamine reuptake inhibition." | 6.43 | Methadone for treatment of cancer pain. ( Bryson, J; Seccareccia, D; Tamber, A; Zimmermann, C, 2006) |
| "Methadone is a synthetic opioid, with mu and delta receptor activity, associated with the capacity to inhibit N-methyl-D-aspartate receptors." | 6.41 | Opioid switch to oral methadone in cancer pain. ( Body, JJ; Lossignol, DA; Mancini, I, 2000) |
| "Methadone doses were changed according to the clinical needs to obtain the most favorable balance between analgesia and adverse effects." | 5.72 | Methadone as First-line Opioid for the Management of Cancer Pain. ( Adile, C; Bonanno, G; Casuccio, A; Ferrera, P; Mercadante, S; Pallotti, MC; Ricci, M, 2022) |
| "Methadone is a synthetic opioid with excellent oral bioavailability, variable, but long duration of action and extremely low cost." | 5.29 | Respiratory depression in a patient receiving oral methadone for cancer pain. ( Bruera, E; Hunt, G, 1995) |
| "Pain in opioid-dependent patients is common but data measuring the course of pain (and its correlates) using validated scales in patients initiating methadone treatment are sparse." | 5.24 | Pain in methadone patients: Time to address undertreatment and suicide risk (ANRS-Methaville trial). ( Bendiane, MK; Carrieri, P; Lions, C; Maradan, G; Michel, L; Mora, M; Morel, A; Nordmann, S; Roux, P; Spire, B; Vilotitch, A, 2017) |
| "Methadone is a potent analgesic used to treat refractory cancer pain." | 5.24 | Can Saliva and Plasma Methadone Concentrations Be Used for Enantioselective Pharmacokinetic and Pharmacodynamic Studies in Patients With Advanced Cancer? ( George, R; Good, P; Hardy, J; Haywood, A; Hennig, S; Khan, S; Norris, R, 2017) |
| " There is little information on methadone use for SCD pain." | 5.22 | Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease. ( Deych, E; Frei-Jones, M; Horst, J; Kharasch, ED; Shannon, W, 2016) |
| "Propofol and isoflurane requirements and preoperative pain scores were not different between groups." | 5.17 | Comparison of perioperative analgesic efficacy between methadone and butorphanol in cats. ( Bauquier, SH; Beths, T; Holm, M; Warne, LN, 2013) |
| "This analysis explored the prevalence and correlates of pain in patients enrolled in methadone maintenance treatment (MMT)." | 5.17 | Epidemiology of pain among outpatients in methadone maintenance treatment programs. ( Dhingra, L; Homel, P; Jordan, AE; Katz, J; Masson, C; McKnight, C; Perlman, DC; Portenoy, RK; Seewald, RM; Wald, E; Young, C, 2013) |
| "This study was designed to evaluate the role of epidural methadone-lidocaine in cancer pain combined or not to epidural dexamethasone." | 5.17 | Epidural methadone results in dose-dependent analgesia in cancer pain, further enhanced by epidural dexamethasone. ( Lauretti, GR; Mattos, AL; Rizzo, CC; Rodrigues, SW, 2013) |
| "Data on the treatment of breakthrough cancer pain (BTcP) in patients receiving methadone therapy are lacking." | 5.15 | The use of fentanyl buccal tablets as breakthrough medication in patients receiving chronic methadone therapy: an open label preliminary study. ( Arcuri, E; Ferrera, P; Mercadante, S, 2011) |
| "The SAG patients reported a trend of more pain, had significantly more dropouts and three SAEs, which indicate that the SAG strategy should not replace the 3DS when switching from high doses of morphine or oxycodone to methadone." | 5.15 | How to switch from morphine or oxycodone to methadone in cancer patients? a randomised clinical phase II trial. ( Dale, O; Kaasa, S; Klepstad, P; Moksnes, K; Paulsen, O; Rosland, JH, 2011) |
| "Methadone was administered to 21 opioid-tolerant cancer patients because of pain (numerical rating scale [NRS] > 5) on morphine (ten patients), transdermal fentanyl (TF; four patients), morphine, ketamine, and TF (one patient), tramadol (one patient), pethidine (one patient), pain with drowsiness on morphine with ketamine (three patients), and pain with nausea on morphine (one patient)." | 5.14 | The role of methadone in opioid rotation-a Polish experience. ( Leppert, W, 2009) |
| "This study aims to evaluate the efficacy of methadone as substitute for morphine and to investigate if the addition of acetaminophen could reduce the time to attain an equianalgesic dose of methadone and/or to improve the level of pain control in oncologic patients." | 5.14 | Early switching from morphine to methadone is not improved by acetaminophen in the analgesia of oncologic patients: a prospective, randomized, double-blind, placebo-controlled study. ( Cubero, DI; del Giglio, A, 2010) |
| "The purpose of this study was to determine the effect of initiation of methadone on QTc interval in patients with cancer pain seen at the palliative care setting." | 5.14 | The effect of oral methadone on the QTc interval in advanced cancer patients: a prospective pilot study. ( Bruera, E; de la Cruz, M; El Osta, B; Hui, D; Palmer, JL; Reddy, S; Walker, P, 2010) |
| "The objective of the study was to describe the experience of methadone use in 100 consecutive chronic pain patients managed in a single multidisciplinary center." | 5.13 | Experience of methadone therapy in 100 consecutive chronic pain patients in a multidisciplinary pain center. ( Evans, D; Galonski, M; Gordon, A; Gourlay, D; Peng, P; Stafford, M; Tumber, P; Wong, P, 2008) |
| "The treatment of acute pain in patients maintained on methadone is difficult due to increased pain sensitivity (hyperalgesia) and cross-tolerance to other opioids." | 5.13 | Antinociceptive effects of high-dose remifentanil in male methadone-maintained patients. ( Bochner, F; Hay, JL; Somogyi, AA; White, JM, 2008) |
| "To compare the effectiveness and side effects of methadone and morphine as first-line treatment with opioids for cancer pain." | 5.11 | Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study. ( Bertolino, M; Bosnjak, S; Bruera, E; Fisch, MJ; Mathias, C; Moyano, J; Palmer, JL; Rico, MA; Spruyt, O; Strasser, F; Sweeney, C; Willey, J, 2004) |
| "Methadone is effective for chronic cancer pain, but its early pharmacodynamic profile and effectiveness for breakthrough pain remain uncertain." | 5.11 | Characterization of the early pharmacodynamic profile of oral methadone for cancer-related breakthrough pain: a pilot study. ( Fisher, K; Hagen, NA; Stiles, C, 2004) |
| "The aim of this study is to characterize patients with chronic pain in methadone maintenance treatment (MMT)." | 5.11 | Significantly higher methadone dose for methadone maintenance treatment (MMT) patients with chronic pain. ( Adelson, M; Gordon, J; Peles, E; Schreiber, S, 2005) |
| "Methadone is a strong opioid analgesic that has been used successfully in cancer pain management." | 5.11 | Intermittent subcutaneous methadone administration in the management of cancer pain. ( Centeno, C; Vara, F, 2005) |
| "This prospective study documents the use of methadone as part of an opioid rotation strategy in patients with uncontrolled pain and severe delirium admitted for terminal care to a tertiary cancer palliative care hospital." | 5.11 | Methadone in the treatment of pain and terminal delirum in advanced cancer patients. ( Comfort, C; Kogan, M; Moryl, N; Obbens, E, 2005) |
| "The successful use of methadone in cancer pain has been supported by numerous case reports and clinical studies." | 5.10 | Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain. ( Derby, S; Fischberg, D; Kornick, C; Manfredi, PL; Moryl, N; Payne, R; Santiago-Palma, J, 2002) |
| "To assess the use of methadone in patients with cancer pain who fail to respond to increasing doses of other opioids or experience intolerable side-effects from them." | 5.09 | Methadone titration in opioid-resistant cancer pain. ( Gonty, N; Scholes, CF; Trotman, IF, 1999) |
| "The use of methadone in the treatment of cancer pain is becoming more attractive mainly because of its known efficacy, lack of active metabolites, and low cost." | 5.09 | Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain. ( Bruera, E; Gagnon, B, 1999) |
| "Fifty-two consecutive cancer patients receiving oral morphine but with uncontrolled pain and/or moderate to severe opioid adverse effects were switched to oral methadone administered every 8 hours using different dose ratios." | 5.09 | Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study. ( Boffi, R; Casuccio, A; Fulfaro, F; Gebbia, V; Groff, L; Mercadante, S; Ripamonti, C; Villari, P, 2001) |
| "In a prospective, open study, 37 advanced cancer patients in poor pain control receiving high doses of subcutaneous hydromorphone (mean daily dose: 276 +/- 163 mg) were switched to methadone by use of custom-made capsules (21 patients) or suppositories (16 patients)." | 5.08 | Custom-made capsules and suppositories of methadone for patients on high-dose opioids for cancer pain. ( Bruera, E; Fainsinger, RL; Inturrisi, C; Spachynski, K; Suarez-Almazor, M; Watanabe, S, 1995) |
| "Methadone is a very useful drug in cancer pain because of its low cost, lack of active metabolites, high oral availability, and the rapid onset of its analgesic effect." | 5.08 | Patient-controlled analgesia with oral methadone in cancer pain: preliminary report. ( Caligara, M; Mercadante, S; Sapio, M; Serretta, R, 1996) |
| "To determine the relationship between changes in plasma methadone concentration and pharmacodynamic effects, plasma methadone profiles and pharmacodynamics (analgesia and sedation) were measured during and after the continuous infusion of methadone for 180 to 270 minutes in 15 patients with pain caused by cancer." | 5.06 | Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain. ( Colburn, WA; Foley, KM; Inturrisi, CE; Max, MB; Portenoy, RK, 1990) |
| "Eighteen patients suffering from cancer were entered into a study of the pharmacokinetics and efficacy of methadone and morphine in pain control." | 5.06 | A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer. ( Cherry, DA; Cousins, MJ; Gourlay, GK, 1986) |
| "This study reports the results of a double-blind, parallel-group comparison of intravenous methadone with morphine for the control of postoperative pain." | 5.06 | A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control. ( Gourlay, GK; Lamberty, J; Willis, RJ, 1986) |
| "Methadone, due to its multimechanistic action profile, is possibly among the most effective and most underutilized opioid analgesics in children with severe unrelieved pain at end of life." | 5.01 | From Tramadol to Methadone: Opioids in the Treatment of Pain and Dyspnea in Pediatric Palliative Care. ( Friedrichsdorf, SJ, 2019) |
| "Methadone is a valuable opioid in the management of patients who have cancer with pain." | 4.98 | Methadone: Maximizing Safety and Efficacy for Pain Control in Patients with Cancer. ( Costantino, RC; McPherson, AL; McPherson, ML, 2018) |
| "We included all studies of methadone used to facilitate weaning from continuous opioid infusions in pediatric critical care patients, including medical, cardiac, and surgical patients, excluding case reports and studies treating neonatal abstinence syndrome, or acute or chronic pain." | 4.95 | The use of methadone to facilitate opioid weaning in pediatric critical care patients: a systematic review of the literature and meta-analysis. ( Dervan, LA; Watson, RS; Wolf, FM; Yaghmai, B, 2017) |
| "To determine the effectiveness and tolerability of methadone as an analgesic in adults and children with cancer pain." | 4.95 | Methadone for cancer pain. ( Derry, S; Nicholson, AB; Watson, GR; Wiffen, PJ, 2017) |
| "The proven therapeutic efficacy of methadone in cancer pain is hindered by a challenging pharmacokinetic-pharmacodynamic profile, considerable interpatient variation, and increasing concern about the complexities of dosing." | 4.90 | Therapeutic challenges in cancer pain management: a systematic review of methadone. ( Afsharimani, B; Good, P; Hardy, J; Haywood, A; Khan, S; Movva, R, 2014) |
| "Methadone and buprenorphine are maintenance replacement therapies for opioid dependence; they are also used for pain management." | 4.89 | Metabolic and toxicological considerations of the opioid replacement therapy and analgesic drugs: methadone and buprenorphine. ( Moody, DE, 2013) |
| "To determine the analgesic efficacy of transdermal fentanyl for relief of cancer pain, and to assess the adverse events associated with the use of transdermal fentanyl for relief of cancer pain." | 4.89 | Transdermal fentanyl for cancer pain. ( Derry, S; Hadley, G; Moore, RA; Wiffen, PJ, 2013) |
| "For the past 20 years, methadone has been experiencing resurgence in the palliative care community as a second-line opioid for the treatment of cancer pain." | 4.87 | Morphine to methadone conversion: an interpretation of published data. ( Baumrucker, SJ; Morgan, V; Pollock, AB; Tegeler, ML, 2011) |
| "Methadone was responsible for the most deaths at 10 (50%), and hydrocodone was second at four deaths (20%) The most common risk factors found in the medical records of decedents included prescriber error in initiating, converting or titrating doses, patient nonadherence to medical instruction, presence of comorbid mental disorders, toxicological presence of benzodiazepines, middle age, and unrelieved pain." | 4.87 | A review of forensic implications of opioid prescribing with examples from malpractice cases involving opioid-related overdose. ( Rich, BA; Webster, LR, 2011) |
| "Methadone is highly effective in treating opioid dependence, and it is also used as an analgesic for second-line management of chronic pain." | 4.86 | Methadone deaths: risk factors in pain and addicted populations. ( Brooks, D; Modesto-Lowe, V; Petry, N, 2010) |
| "Methadone is increasingly prescribed for chronic pain, yet the associated mortality appears to be rising disproportionately relative to other opioid analgesics." | 4.85 | Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation. ( Andrews, CM; Capacchione, JF; Haigney, MC; Krantz, MJ; Marcuson, MJ; Wedam, EF, 2009) |
| "To summarize the unique characteristics of methadone and the putative mechanisms of rapid-onset opioid formulations for breakthrough pain; to outline the principles underlying opioid rotation; and to describe elements of risk assessment in opioid therapy." | 4.85 | Clinical approaches to special issues related to opioid therapy. ( Fine, PG, 2009) |
| "To outline pharmacodynamics, pharmacokinetics, drug interactions, equianalgesic dose ratio with other opioids, dosing rules, adverse effects and methadone clinical studies in patients with cancer pain." | 4.85 | The role of methadone in cancer pain treatment--a review. ( Leppert, W, 2009) |
| " Alternative approaches with methadone, ketamine, or local anesthetics should be considered." | 4.84 | Pharmacological approaches to the management of pain in the neonatal intensive care unit. ( Anand, KJ, 2007) |
| "Methadone is an opioid used in the management of cancer pain." | 4.84 | Methadone for cancer pain. ( Nicholson, AB, 2007) |
| "This topical review addresses methadone's pharmacology, its application in malignant and non-malignant pain conditions, practical issues related to methadone for the treatment of pain and its influence on QTc time." | 4.84 | Clinical pharmacology of methadone for pain. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Moksnes, K, 2008) |
| "Methadone, an opioid analgesic, is used clinically in pain therapy as well as for substitution therapy in opioid addiction." | 4.84 | Interindividual variability of methadone response: impact of genetic polymorphism. ( Davani, S; Gerritsen-van Schieveen, P; Kantelip, JP; Li, Y, 2008) |
| "Once used only as third-line therapy for chronic pain management, methadone is now being used as first- and second-line therapy in palliative care." | 4.84 | Consensus guideline on parenteral methadone use in pain and palliative care. ( Berger, A; Blinderman, CD; Bruera, E; Davis, MP; Derby, S; Inturrisi, C; Kalman, J; Mehta, D; Pappagallo, M; Perlov, E; Shaiova, L, 2008) |
| " Evidence presented in this review shows encouraging results following the administration of methadone, fentanyl or ketamine to patients with difficult pain problems." | 4.82 | Morphine is not the only analgesic in palliative care: literature review. ( Wootton, M, 2004) |
| "Methadone is an opioid used in the management of cancer pain both in opioid naïve patients and in rotation from other opioids." | 4.82 | Methadone for cancer pain. ( Nicholson, AB, 2004) |
| "This article reviews the unique pharmacological properties of methadone and outlines its appropriate clinical application, with focus upon its use in the treatment of chronic pain." | 4.82 | Methadone: applied pharmacology and use as adjunctive treatment in chronic pain. ( Brown, R; Fleming, M; Kraus, C; Reddy, S, 2004) |
| "Methadone, although having been available for approximately half a century, is now receiving increasing attention in the management of chronic pain." | 4.82 | A review of the use of methadone for the treatment of chronic noncancer pain. ( Lynch, ME, 2005) |
| "Methadone is a synthetic opioid that is effective for the relief of moderate-to-severe pain and for the treatment of opioid dependence." | 4.82 | Pharmacokinetics of methadone. ( Kern, SE; Lugo, RA; Satterfield, KL, 2005) |
| " Several studies have demonstrated that methadone is a valid alternative to morphine, hydromorphone, and fentanyl for the treatment of cancer-related pain, and extensive reviews on the subject have been published in recent years [10,23,25,64,70,71]." | 4.81 | The use of methadone for cancer pain. ( Bianchi, M; Ripamonti, C, 2002) |
| "Methadone hydrochloride is a mu-opioid agonist that has been used for the treatment of pain and for the management and maintenance of opioid withdrawal for over 50 years." | 4.81 | Clinical use of methadone. ( Goode, JV; Layson-Wolf, C; Small, RE, 2002) |
| "Methadone, a synthetic opioid, has unique pharmacodynamics and pharmacokinetics, which contribute to its unique ability to relieve pain unresponsive to other potent opiates and its unique dosing and drug interactions." | 4.81 | Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration. ( Davis, MP; Walsh, D, 2001) |
| "In recent years a better understanding of the pharmacologic and pharmacokinetic properties of methadone, including equianalgesic ratios has led to its increased use as a second line opioid for the treatment of pain in patients with cancer." | 4.81 | Methadone use in cancer patients with pain: a review. ( Bruera, E; Sweeney, C, 2002) |
| "From August 2021 to March 2022, a pharmacist guided implementation of a pilot sOAT protocol consisting of escalating doses of oxycodone or oral hydromorphone scheduled every four hours, intravenous hydromorphone as needed, and non-opioid adjuvants for withdrawal and pain." | 4.31 | Safety and preliminary outcomes of short-acting opioid agonist treatment (sOAT) for hospitalized patients with opioid use disorder. ( Caputo, A; Christopher, C; Compton, P; Delgado, MK; Lowenstein, M; McFadden, R; Olenik, JM; Perrone, J; Ronning, K; Sigueza, AL; Thakrar, AP; Uritsky, TJ; Winston, A, 2023) |
| " Among those on methadone or buprenorphine (N = 108), multivariable logistic regression models examined the association between socio-demographics, MOUD type; and past-30-day use of heroin/fentanyl; crack; benzodiazepines; and pain medications." | 4.31 | Drug use patterns and factors related to the use and discontinuation of medications for opioid use disorder in the age of fentanyl: findings from a mixed-methods study of people who use drugs. ( Case, P; Green, TC; Hughto, JMW; Moyo, P; Palacios, WR; Rapisarda, SS; Silcox, J; Stopka, TJ; Tapper, A, 2023) |
| "Slow-release oral morphine (SROM) is used to manage pain, and as opioid agonist treatment (OAT)." | 4.31 | Assessing the impact of the slow-release oral morphine drug shortages in Ontario, Canada: A population-based time series analysis. ( Besharah, J; Campbell, T; Gomes, T; Kleinman, RA; Kolla, G; Ledlie, S; Leece, P; McCormack, D; Smoke, A; Sproule, B; Tadrous, M, 2023) |
| " There was a significant decrease in propofol and fentanyl utilization from 24 hours pretracheostomy to 24 hours posttracheostomy in both dose and number of patients receiving these continuous intravenous medications." | 4.12 | Tracheostomy decreases continuous analgesia and sedation requirements. ( Droege, CA; Elson, NC; Goodman, MD; Hayes, HV; Nomellini, V; Pritts, TA; Salvator, A; Singer, KE; Wallen, TE, 2022) |
| " This patient was taking methadone for neoplasm related pain." | 4.12 | Lucid Dreams Associated with Pregabalin: Implications for Clinical Practice. ( Chang, YD; Craig, DS; Guastella, AM; Haas, MF; Latchman, J, 2022) |
| " Opioid exposure during pregnancy included 16 202 pregnancies exposed to codeine, 4540 to oxycodone, 1244 to tramadol, 260 to methadone (dispensed for pain), 90 to hydromorphone, and 63 to morphine compared with 25 710 exposed to hydrocodone." | 4.12 | Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns. ( Bateman, BT; Esposito, DB; Hernández-Díaz, S; Huybrechts, KF; Mogun, H; Straub, L; Werler, MM, 2022) |
| "Methadone is an evidence-based treatment for opioid use disorder (OUD) and pain management." | 4.12 | Pronounced Regional Disparities in United States Methadone Distribution. ( Furst, JA; McCall, KL; Mynarski, NJ; Piper, BJ, 2022) |
| " Of the seven articles, all seven reported some improvement in pain with the addition of low-dose or adjuvant methadone." | 4.12 | Efficacy of low-dose and/or adjuvant methadone in palliative medicine. ( Chalker, C; Cranfield, F; O'Neill, H, 2022) |
| " While these agents have clinical utility supported by robust literature, we the authors posit that buprenorphine is a superior therapy for both opioid use disorder (OUD) as well as pain." | 4.02 | A history of opioid abuse: Why buprenorphine is superior for the management of opioid use disorder and pain. ( Komrowski, MD; Sekhri, NK, 2021) |
| "One-hundred-and-sixty-four patients receiving methadone maintenance treatment completed a battery of self-report measures related to alexithymia, drug use, and pain experiences." | 4.02 | Alexithymia and pain experience among patients using methadone-maintenance therapy. ( Barry, DT; Beitel, M; Gaeta, M; Morie, KP; Oberleitner, DE; Oberleitner, LM; Potenza, MN; Roos, CR; Yip, SW, 2021) |
| "Methadone is an effective medication for treating pain and has unique characteristics that require specialized knowledge to prescribe safely." | 4.02 | Methadone for Palliative Care Providers: A Case-Based Flipped Classroom Module for Faculty and Fellows. ( Biewald, MA; Lindenberger, E; Scarborough, B, 2021) |
| "Methadone is a complex but useful medication for pain management in palliative care." | 3.96 | Comparing Methadone Rotation to Consensus Opinion. ( Quirk, KC; Rodgers, PE; Saul, DC; Silveira, MJ; Smith, MA, 2020) |
| "Methadone has several unique characteristics that make it an attractive option for pain relief in serious illness, but the safety of methadone has been called into question after reports of a disproportionate increase in opioid-induced deaths in recent years." | 3.91 | Safe and Appropriate Use of Methadone in Hospice and Palliative Care: Expert Consensus White Paper. ( Bemben, NM; Bruera, E; Chou, R; Davis, MP; Lapointe, BJ; Lockman, DK; Malotte, K; McPherson, ML; Paice, J; Ray, JB; Reddy, A; Salpeter, S; Walker, KA; Wellman, C, 2019) |
| " In light of the ongoing opioid epidemic, the purpose of the current study was to understand the prevalence and health-related correlates of loss of control (LOC) eating in adults seeking methadone maintenance treatment primarily for addiction to heroin and/or painkillers." | 3.88 | Prevalence and Correlates of Loss of Control Eating among Adults Presenting for Methadone Maintenance Treatment. ( Bond, DS; Bryson, WC; Cotton, BP; Goldschmidt, AB; Laurent, J; Mackey, S, 2018) |
| " Methadone is an opioid prescribed for pain management and is also provided through opioid treatment programs to treat opioid use disorders." | 3.85 | Methadone Prescribing and Overdose and the Association with Medicaid Preferred Drug List Policies - United States, 2007-2014. ( Alexander, C; Bohm, M; Faul, M, 2017) |
| "Methadone use as a second-line agent for severe cancer-related pain is increasing in the field of hospice and palliative care." | 3.85 | Methadone-Induced Neurotoxicity in Advanced Cancer: A Case Report. ( Hartwig, KN; Hoff, AM; Rosielle, DA, 2017) |
| "Many factors make methadone an appealing option for treatment of pain in patients seen by palliative care; however, complex drug-related properties and variable patient response complicate appropriate conversion ratios from other opioids to methadone." | 3.85 | Methadone Dose Selection for Treatment of Pain Compared with Consensus Recommendations. ( Ajayi, TA; Atayee, RS; Edmonds, KP; Karimian, P, 2017) |
| "To date there have been no studies investigating the characteristics of pain in Chinese heroin-dependent patients (HDPs) receiving methadone maintenance treatment (MMT)." | 3.85 | Prevalence of pain and its socio-demographic and clinical correlates among heroin-dependent patients receiving methadone maintenance treatment. ( Chen, WC; Lu, J; Xu, YM; Yang, YJ; Zhong, BL; Zhu, JH, 2017) |
| "Use of the prescription opioid methadone for treatment of pain, as opposed to treatment of opioid use disorder (e." | 3.83 | Trends in Methadone Distribution for Pain Treatment, Methadone Diversion, and Overdose Deaths - United States, 2002-2014. ( Baldwin, GT; Jones, CM; Mack, KA; Manocchio, T; White, JO, 2016) |
| "Methadone offers many advantages for treating cancer pain." | 3.83 | Methadone as a Coanalgesic for Palliative Care Cancer Patients. ( Courtemanche, F; Dao, D; Gagné, F; Néron, A; Tremblay, L, 2016) |
| "The use of very-low-dose methadone in conjunction with haloperidol in the acute-care setting resulted in improved pain control after conversion from typical opiates." | 3.81 | The use of very-low-dose methadone and haloperidol for pain control in the hospital setting: a preliminary report. ( Bruera, E; Buckley, JS; Buckley, NS; Salpeter, SR, 2015) |
| "Pregnant women filling at least one prescription for an opioid analgesic at any time during pregnancy for whom opioid exposure characteristics including duration of therapy: short term (<30 days) or long term (≥ 30 days); timing of use: early use (only in the first two trimesters) or late use (extending into the third trimester); and cumulative dose (in morphine equivalent milligrams) were assessed." | 3.81 | Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study. ( Bateman, BT; Desai, RJ; Hernandez-Diaz, S; Huybrechts, KF; Kaltenbach, K; Kerzner, LS; Mogun, H; Patorno, E, 2015) |
| "Antinociceptive effect of narcotic analgesics, fentanyl, oxycodone and methadone in inflammatory pain state was described in the von Frey filament test using the complete Freund's adjuvant (CFA)-induced mouse inflammatory pain model." | 3.80 | Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state. ( Aoki, Y; Mizoguchi, H; Sakurada, S; Sakurada, T; Watanabe, C, 2014) |
| "There are few studies that describe cardiac adverse events in patients prescribed methadone for pain management." | 3.80 | Methadone for pain and the risk of adverse cardiac outcomes. ( Delate, T; Kurz, D; Price, LC; Shanahan, R; Wobeter, B, 2014) |
| "We describe a child with acute myeloid leukemia (AML) who developed severe central sleep apnea (CSA) on methadone therapy for chronic pain management." | 3.79 | Severe central sleep apnea in a child with leukemia on chronic methadone therapy. ( Amos, LB; D'Andrea, LA, 2013) |
| "The responses pertaining to opioid agreements, urine drug testing, acetaminophen, and treatment for neuropathic pain are reassuring in that they prevent misuse and abuse of opioids, prevent acetaminophen-induced hepatotoxicity, and reflect evidence-based treatments." | 3.79 | Prescription patterns of pain medicine physicians. ( Avram, MJ; Benzon, HA; Benzon, HT; Cox, P; Dean, K; Katz, JA; Kendall, MC; Malik, K, 2013) |
| "Previous research has reported improved pain after adding methadone to another opioid, but did not quantify this benefit using a validated outcome measure." | 3.79 | Addition of methadone to another opioid in the management of moderate to severe cancer pain: a case series. ( Bryson, J; Mak, E; Ridley, J; Wallace, E; Zimmermann, C, 2013) |
| " This study explores the correlates of depression among a sample of methadone maintained treatment (MMT) adults in the Los Angeles area, and is part of a larger study on hepatitis health promotion among MMT clients who use alcohol." | 3.78 | Correlates of depressive symptoms among alcohol-using methadone maintained adults. ( Albarrán, CR; Branson, C; Khalilifard, F; Leake, B; Marfisee, M; Nyamathi, A, 2012) |
| "Opioid switching to methadone is reported frequently to improve pain control in patients with an unacceptable balance between pain control and side effects during treatment with first line opioids, but carries a risk of drug accumulation and respiratory depression." | 3.78 | Opioid switching to methadone: a pharmacoepidemiological study from a national prescription database. ( Borchgrevink, PC; Fredheim, OM; Moksnes, K; Skurtveit, S, 2012) |
| "A retrospective, systematic chart review of levo-methadone conversions for the treatment of pain in inpatient palliative care was performed." | 3.78 | Practicability, safety, and efficacy of a "German model" for opioid conversion to oral levo-methadone. ( Gaertner, J; Klein, C; Nauck, F; Ostgathe, C; Sabatowski, R; Van Aaaken, A; Voltz, R, 2012) |
| "Switching to methadone from different opioids, using an initial fixed ratio followed by a flexible dosing, according to the clinical need, is highly effective and safe when performed in an acute pain relief and palliative care unit." | 3.78 | Switching methadone: a 10-year experience of 345 patients in an acute palliative care unit. ( Mercadante, S, 2012) |
| "The success of rehabilitation is not influenced solely by drug abstinence, but also by the state of general health and well-being, which for patients in methadone maintenance treatment (MMT) frequently is compromised by experiencing pain, depression and sleep disorders." | 3.78 | Pain depression and sleep disorders among methadone maintenance treatment patients. ( Lawental, E; Pud, D; Zlotnick, C, 2012) |
| "Vital statistics data suggest that the opioid pain reliever (OPR) methadone is involved in one third of OPR-related overdose deaths, but it accounts for only a few percent of OPR prescriptions." | 3.78 | Vital signs: risk for overdose from methadone used for pain relief - United States, 1999-2010. ( , 2012) |
| "The reports on pain perception among former heroin addicts receiving methadone maintenance treatment (MMT) vary with regard to pain and intolerance threshold, and perception of suprathreshold stimuli has not been previously evaluated." | 3.77 | The differential effect of methadone dose and of chronic pain on pain perception of former heroin addicts receiving methadone maintenance treatment. ( Adelson, M; Defrin, R; Hetzroni, T; Peles, E; Schreiber, S, 2011) |
| "Differences in lifetime trauma exposure and screened symptoms of posttraumatic stress disorder (PTSD) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences." | 3.77 | Exploring relations among traumatic, posttraumatic, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Cutter, CJ; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2011) |
| "The aim of this study was to examine the association of pain catastrophizing and pain coping strategies with characteristic pain intensity (an average of worst, least, and typical pain intensity in the past week) and recent pain-related disability (an average of three measures of past week pain interference) in opioid-dependent patients enrolled in a methadone maintenance treatment program (MMTP) who reported recent pain." | 3.77 | Pain catastrophizing and pain coping among methadone-maintained patients. ( Barry, DT; Beitel, M; Cutter, CJ; Garnet, B; Peters, S; Savant, J; Schottenfeld, RS, 2011) |
| " Our objective was to compare mortality rates among patients who received prescribed methadone or long-acting morphine for pain." | 3.77 | Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain. ( Bair, MJ; Becker, WC; Hui, S; Krebs, EE; McCoy, K; Zerzan, J, 2011) |
| "A case of severe constipation is described in a 75-year- old cancer patient receiving methadone for pain." | 3.77 | Neostigmine for the treatment of gastrointestinal atony: a report of one case. ( Papa, P; Turconi, L, 2011) |
| "We have demonstrated previously that former opiate-dependent subjects treated and detoxified from methadone maintenance therapy suffer deficits in neuropsychological performance and have abnormal pain thresholds." | 3.77 | The effect of pain on stroop performance in patients with opiate dependence in sustained remission. ( Aniskin, DB; Boda, N; Cohen, LJ; Fink, E; Galynker, II; Prosser, J; Steinfeld, M, 2011) |
| "Methadone is a long-acting opioid used in the treatment of various pain states and substitution therapy in heroin addiction." | 3.77 | Characterization of the antinociceptive effects of the individual isomers of methadone after acute and chronic administrations. ( Morgan, RW; Nicholson, KL, 2011) |
| "This study found no differences in the pain responses of ME infants and non-exposed infants when given sucrose during heel lance procedures." | 3.76 | Efficacy of oral sucrose in infants of methadone-maintained mothers. ( Marceau, JR; Murray, H; Nanan, RK, 2010) |
| "Methadone is an effective and inexpensive opioid for cancer pain treatment." | 3.76 | Methadone initiation and rotation in the outpatient setting for patients with cancer pain. ( Bruera, E; Calderon, B; de la Cruz, M; El Osta, B; Li, Z; Palmer, JL; Parsons, HA, 2010) |
| "We conducted a feasibility study of sublingual methadone for breakthrough cancer pain, to determine whether a larger, randomized trial was warranted, and to identify a study design that would be likely to succeed." | 3.76 | A formal feasibility study of sublingual methadone for breakthrough cancer pain. ( Biondo, PD; Brasher, PM; Eliasziw, M; Hagen, NA; Moulin, DE; Stiles, CR; Watanabe, SM, 2010) |
| "This observational study aimed to determine whether pain sensitivity in patients with noncancer chronic pain, taking either methadone or morphine, is similar to patients maintained on methadone for dependence therapy, compared with a control group." | 3.75 | Hyperalgesia in opioid-managed chronic pain and opioid-dependent patients. ( Bochner, F; Hay, JL; Rounsefell, B; Semple, TJ; Somogyi, AA; White, JM, 2009) |
| " We sought first to explore providers' perceptions of ambiguity, and then to examine their strategies for making diagnostic and treatment decisions to manage chronic pain among patients on methadone maintenance therapy." | 3.75 | Providers' experiences treating chronic pain among opioid-dependent drug users. ( Arnsten, JH; Berg, KM; Karasz, A; Sacajiu, G, 2009) |
| "Methadone is an excellent choice for pain in frail older adults." | 3.75 | Methadone: an effective, safe drug of first choice for pain management in frail older adults. ( Gallagher, R, 2009) |
| "Methadone is often used as an alternative for pain management." | 3.75 | Methadone antinociception is dependent on peripheral opioid receptors. ( He, L; Kim, J; McFadden, W; Ou, C; van Rijn, RM; Whistler, JL, 2009) |
| "Following the findings of perceived poor sleep and of chronic pain among former heroin addicts, current methadone maintenance treatment (MMT) patients, and its possible relation to methadone dose, we studied these patients' objective sleep parameters." | 3.75 | Documented poor sleep among methadone-maintained patients is associated with chronic pain and benzodiazepine abuse, but not with methadone dose. ( Adelson, M; Peles, E; Schreiber, S, 2009) |
| "Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients." | 3.75 | Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009) |
| "Differences in psychiatric distress and substance use (licit and illicit) were examined in methadone maintenance treatment (MMT) patients with a variety of pain experiences." | 3.75 | Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients. ( Barry, DT; Beitel, M; Garnet, B; Joshi, D; Rosenblum, A; Schottenfeld, RS, 2009) |
| "To investigate the possibility of utilizing the ratio of the methadone metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), to urine creatinine to develop a regression model that would predict drug adherence in patients prescribed methadone for either pain management or drug addiction." | 3.75 | Quantification of a methadone metabolite (EDDP) in urine: assessment of compliance. ( Larson, ME; Richards, TM, 2009) |
| " Chronic intrathecal morphine or methadone significantly increased spinal glial activation (toll-like receptor 4 mRNA and protein) and the expression of multiple chemokines and cytokines, combined with development of analgesic tolerance and pain enhancement (hyperalgesia, allodynia)." | 3.74 | Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia. ( Baker, EM; Coats, BD; Hutchinson, MR; Jekich, BM; Judd, CM; Lewis, SS; Maier, SF; Martin, D; Poole, S; Rezvani, N; Somogyi, AA; Sprunger, DB; Watkins, LR; Wieseler, JL; Zhang, Y, 2008) |
| "Methadone maintained treatment (MMT) patients may be given less opioid analgesia for acute pain than the general patient, due to requests for analgesia being misinterpreted as craving for drugs." | 3.74 | Management of acute pain in methadone maintenance therapy in-patients. ( Curry, K; Fong, D; Hines, S; Theodorou, S; Williamson, A, 2008) |
| "The use of methadone may be difficult and its use in the treatment of chronic non-malignant pain is only sparsely described in literature, whereas several works have shown the advantage of methadone in the treatment of cancer pain." | 3.74 | [Methadone in the treatment of chronic non-malignant pain]. ( Bendiksen, A; Handberg, G; McGehee, E, 2007) |
| "Methadone treatment in chronic pain patients is still limited owing to misconceptions about addiction, safety, and its unique pharmacokinetic and pharmacodynamic properties." | 3.74 | Nurse case management program of chronic pain patients treated with methadone. ( Lamb, L; Pereira, JX; Shir, Y, 2007) |
| "Among the many patients served by methadone maintenance treatment programs (MMTPs) is a small population with severe, refractory pain that may be effectively managed using long-term opioid therapy." | 3.74 | MMTP patients with chronic pain switching to pain management clinics. A problem or an acceptable practice? ( Altilio, T; Bookbinder, M; Cruciani, RA; Esteban, S; Portenoy, RK; Seewald, RM; Sheu, R, 2008) |
| "Iatrogenic opioid addiction among chronic pain patients was the initiative for starting a methadone programme for pain patients at the University Hospital of Uppsala." | 3.73 | Methadone treatment of chronic non-malignant pain and opioid dependence--a long-term follow-up. ( Gordh, T; Grönbladh, L; Nilsson, LH; Rhodin, A, 2006) |
| "Vulnerability to delirium was potentially caused by coadministration of methadone, which can inhibit the CYP2D6 isozyme." | 3.73 | Dextromethorphan-induced delirium and possible methadone interaction. ( Lotrich, FE; Pollock, BG; Rosen, J, 2005) |
| "Both clinicians and researchers have expressed doubt that opiate dependent patients with significant pain can be effectively treated in methadone maintenance treatment (MMT) programs; however, little research exists on this topic." | 3.73 | Response to methadone maintenance treatment of opiate dependent patients with and without significant pain. ( Humphreys, K; Ilgen, MA; Trafton, JA, 2006) |
| "Twelve patients with poor pain control or unacceptable side effects during treatment with morphine were switched to methadone and followed for nine months in this open prospective study." | 3.73 | Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study. ( Borchgrevink, PC; Dale, O; Fredheim, OM; Kaasa, S; Klepstad, P; Landrø, NI, 2006) |
| "Although studies on the beliefs of persons with chronic nonmalignant pain (CNMP) are still scarce, methadone is increasingly prescribed for the treatment of CNMP." | 3.73 | Response phases in methadone treatment for chronic nonmalignant pain. ( Arnaert, A; Ciccotosto, G, 2006) |
| "We studied the effects of the commonly used mu-opioid receptor agonists morphine, oxycodone, methadone and the enantiomers of methadone in thermal and mechanical models of acute pain and in the spinal nerve ligation model of neuropathic pain in rats." | 3.73 | Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat. ( Kalso, E; Kontinen, VK; Kylänlahti, I; Lemberg, K; Viljakka, K; Yli-Kauhaluoma, J, 2006) |
| "Racemic methadone is increasingly used to manage cancer pain." | 3.73 | Pharmacokinetics and pharmacodynamics of methadone enantiomers in hospice patients with cancer pain. ( Auret, K; Boyd, F; Ilett, KF; Oh, TE; Page-Sharp, M; Roger Goucke, C, 2006) |
| "Methadone hydrochloride is an effective, inexpensive, and relatively safe opioid to use in the treatment of patients with chronic pain." | 3.73 | Prescribing methadone for pain management in end-of-life care. ( Manfredonia, JF, 2005) |
| "Methadone has been used as an alternative strong opioid to morphine in the management of cancer pain." | 3.72 | An ad libitum schedule for conversion of morphine to methadone in advanced cancer patients: an open uncontrolled prospective study in a Chinese population. ( Ma, HM; Ng, DK; Sham, MM; Tse, DM, 2003) |
| "To estimate the prevalence and to examine the characteristics of chronic severe pain in chemically dependent populations receiving methadone maintenance or inpatient residential treatment." | 3.72 | Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. ( Cleland, C; Fong, C; Joseph, H; Kipnis, S; Portenoy, RK; Rosenblum, A, 2003) |
| "To investigate the relationship between the daily dose of the synthetic opioid methadone and the corrected QT (QTc) interval in a series of methadone-treated patients who developed torsade de pointes." | 3.72 | Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. ( Krantz, MJ; Kutinsky, IB; Mehler, PS; Robertson, AD, 2003) |
| "The objectives of this medico-legal case report were the following: 1) To present an example of a medico-legal problem that developed as a result of a decision to rotate a chronic pain patient (CPP) to methadone in order to taper the CPP from oxycodone; 2) To present both the plaintiff's and defendant's expert witnesses' opinions as to if and where the care of that patient fell below the "standard of medical care;" and 3) Based on these opinions, to develop some recommendations on how, in the future, pain medicine physicians and other physicians should proceed, in order to avoid allegations of breach of "standards of care" when using methadone." | 3.72 | Medico-legal rounds: medico-legal issues and alleged breaches of "standards of medical care" in opioid rotation to methadone: a case report. ( Cole, B; Cutler, RB; Fishbain, DA; Lewis, J; Rosomoff, HL; Rosomoff, RS, 2003) |
| "To assess the outcomes of infants born to mothers receiving methadone for the management of pain in pregnancy." | 3.72 | Outcomes of infants born to mothers receiving methadone for pain management in pregnancy. ( Kuschel, C; Sharpe, C, 2004) |
| "Recent studies indicate that severe chronic pain is common among patients in methadone maintenance treatment (MMT), but no qualitative studies have examined such patients' experiences of pain and pain treatment." | 3.72 | The experience of chronic severe pain in patients undergoing methadone maintenance treatment. ( Arnstein, J; Arnsten, JH; Berg, K; Gourevitch, M; Karasz, A; Selwyn, P; Zallman, L, 2004) |
| "We describe an opioid-tolerant patient with severe acute pain which was unrelieved by morphine and ketamine via intravenous patient-controlled analgesia, but almost totally relieved by methadone." | 3.71 | Successful use of oral methadone after failure of intravenous morphine and ketamine. ( Mitchell, SJ; Sartain, JB, 2002) |
| "To evaluate a series of methadone-treated patients experiencing torsade de pointes." | 3.71 | Torsade de pointes associated with very-high-dose methadone. ( Hays, H; Krantz, MJ; Lewkowiez, L; Mehler, PS; Robertson, AD; Woodroffe, MA, 2002) |
| "An expert working group of the European Association for Palliative Care has revised and updated its guidelines on the use of morphine in the management of cancer pain." | 3.71 | Morphine and alternative opioids in cancer pain: the EAPC recommendations. ( Casas, JR; Cherny, N; Conno, F; Hanks, GW; Hanna, M; Kalso, E; McQuay, HJ; Mercadante, S; Meynadier, J; Poulain, P; Radbruch, L; Ripamonti, C; Sawe, J; Twycross, RG; Ventafridda, V, 2001) |
| "Methadone is still regarded as a second line opioid for patients suffering from severe pain, and is rarely used in hospitalized patients." | 3.71 | Methadone is safe for treating hospitalized patients with severe pain. ( Davidson, EM; Rosen, G; Shir, Y; Zeldin, A, 2001) |
| "The practice included 61 patients who received pain medication through implanted intrathecal catheter pumps, 19 of whom were treated with morphine, either alone or in combination with other medications." | 3.71 | Neurologic complications including paralysis after a medication error involving implanted intrathecal catheters. ( Craig, AS; Feler, CA; Jones, TF; Melton, K; Moore, WL; Schaffner, W; Simmons, BP; Smith, MD, 2002) |
| "In a patient on methadone maintenance treatment, admitted for lung cancer suspicion, a slight decrease in pain dose response to morphine have necessitated adjustments of methadone treatment founded on clinical check-up and methadone assay." | 3.71 | Slow metabolism and long half life of methadone in a patient with lung cancer and cirrhosis. ( Beauverie, P; Edel, YA; Furlan, V, 2001) |
| "Current equianalgesic reference tables, based largely on single dose studies, give dose ratios of 1:1 to 4:1 for oral morphine to oral methadone, which possibly are inaccurate in patients with cancer pain who are exposed to multiple doses of these opioids." | 3.70 | Dose ratio between morphine and methadone in patients with cancer pain: a retrospective study. ( Bruera, ED; Hanson, J; Lawlor, PG; Turner, KS, 1998) |
| "Oral methadone is considered to be a valid opioid analgesic alternative to morphine and hydromorphone in treating cancer pain." | 3.70 | Equianalgesic dose/ratio between methadone and other opioid agonists in cancer pain: comparison of two clinical experiences. ( Belzile, M; Bruera, E; De Conno, F; Groff, L; Hanson, J; Pereira, J; Ripamonti, C, 1998) |
| "To define the dose ratio between morphine and methadone in relation to the previous morphine dose and the number of days needed to achieve the same level of analgesia in a group of patients with advanced cancer with pain who switched from morphine to oral methadone." | 3.70 | Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio? ( Brunelli, C; De Conno, F; Groff, L; Polastri, D; Ripamonti, C; Stavrakis, A, 1998) |
| " In the past 2 years, oral methadone has been used extensively in our institution for treating children with persistent pain from cancer, burns, or trauma who were capable of oral intake and whose pain was not relieved by nonopioid medications." | 3.70 | Oral methadone for the treatment of severe pain in hospitalized children: a report of five cases. ( Davidson, EM; Rosen, G; Shavelson, V; Shenkman, Z; Shir, Y, 1998) |
| "Chronic pain patients who have limited access to opioids may be redirected to methadone maintenance centers for management of their pain." | 3.70 | Characteristics of methadone maintenance patients with chronic pain. ( Jamison, RN; Katz, NP; Kauffman, J, 2000) |
| "Hyperalgesia and allodynia in 4 cancer patients treated with morphine disappeared after discontinuing or substituting morphine with other opioid agonists." | 3.69 | Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists. ( Jensen, NH; Jensen, TS; Sjøgren, P, 1994) |
| "We evaluated the analgesia, tolerability and absorption profile of methadone hydrochloride in six opioid-naive cancer patients with pain." | 3.69 | Rectal methadone in cancer patients with pain. A preliminary clinical and pharmacokinetic study. ( Brunelli, C; De Conno, F; Lodi, F; Ripamonti, C; Rizzio, E; Saita, L; Zecca, E, 1995) |
| "Five patients with chronic nonmalignant pain were transferred from other analgesics to oral methadone." | 3.69 | Oral methadone for managing chronic nonmalignant pain. ( Gardner-Nix, JS, 1996) |
| "The aims of this study were to describe the analgesia, side effects, and dosage and the causes of suspension of treatment in a large sample of advanced cancer patients with pain after treatment with oral methadone from 7 to 90 days." | 3.69 | Clinical experience with oral methadone administration in the treatment of pain in 196 advanced cancer patients. ( Brunelli, C; De Conno, F; Groff, L; Ripamonti, C; Ventafridda, V; Zecca, E, 1996) |
| "Methadone is a very effective second-line opioid for treatment of cancer pain." | 3.69 | Intravenous methadone for cancer pain unrelieved by morphine and hydromorphone: clinical observations. ( Borsook, D; Chandler, SW; Manfredi, PL; Payne, R, 1997) |
| "Determination of methadone (MET) in biological fluids can serve to adjust dosages in patients suffering from cancer pain or participating in methadone maintenance programs." | 3.68 | Rapid determination of methadone in plasma, cerebrospinal fluid, and urine by gas chromatography and its application to routine drug monitoring. ( Brune, K; Geisslinger, G; Schmidt, N; Sittl, R, 1993) |
| "We report a case of high-dose methadone prescribed to a heroin addict for pain control." | 3.68 | High-dose methadone and the need for drug measurements in plasma. ( Hay, A; Raistrick, D; Wolff, K, 1991) |
| "Concentrations of methadone in plasma, estimates of pain relief, and pupillary size were determined after a single intravenous dose (10 to 30 mg) of methadone hydrochloride to eight patients with chronic pain, five of whom had cancer." | 3.67 | Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain. ( Colburn, WA; Foley, KM; Houde, RW; Inturrisi, CE; Kaiko, RF, 1987) |
| "Dipipanone hydrochloride raised the threshold to ischaemic pain in healthy human volunteers." | 3.63 | Analgesic activity of dipipanone hydrochloride in student volunteers. ( CAHAL, DA, 1957) |
| "Pain, drug cravings, and opioid withdrawal symptoms can interfere with substance use disorder or opioid tapering treatment goals." | 3.11 | Hyperbaric Oxygen Therapy for Pain, Opioid Withdrawal, and Related Symptoms: A Pilot Randomized Controlled Trial. ( Bindler, RJ; Layton, ME; Quock, RM; Stanek, K; Wilson, M, 2022) |
| "Pain was not found to be different between the treatment arms." | 2.94 | A single-institution, randomized, pilot study evaluating the efficacy of gabapentin and methadone for patients undergoing chemoradiation for head and neck squamous cell cancer. ( Attwood, K; Bourgeois, DJ; Hermann, GM; Iovoli, AJ; Miller, A; Platek, AJ; Singh, AK; Wang, C, 2020) |
| "To evaluate the antinociceptive effects of intravenous methadone combined with detomidine or acepromazine in adult horses." | 2.82 | Antinociceptive effects of methadone combined with detomidine or acepromazine in horses. ( Crosignani, N; Lopes, C; Luna, SP; Pantoja, JC; Puoli, JN; Quarterone, C; Rosa, AC; Taylor, PM, 2016) |
| "Forty-two cancer patients with pain and/or opioid side effects were assessed in this randomised trial." | 2.77 | Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain. ( Dale, O; Kaasa, S; Moksnes, K; Paulsen, Ø; Rosland, JH; Spigset, O, 2012) |
| "Methadone was administered via IV (0." | 2.76 | Plasma concentrations and behavioral, antinociceptive, and physiologic effects of methadone after intravenous and oral transmucosal administration in cats. ( Aguiar, AJ; Ferreira, TH; Hudachek, SF; Mama, KR; Rezende, ML, 2011) |
| "Providing pain management for known opioid abusers is a challenging clinical task, in part because little is known about their pain experience and analgesic requirements." | 2.69 | Pain responses in methadone-maintained opioid abusers. ( Charuvastra, VC; Compton, P; Kintaudi, K; Ling, W, 2000) |
| " The pharmacokinetic parameters of the R- and S-enantiomers of the racemate are reported." | 2.68 | Stereoselective pharmacokinetics of methadone in chronic pain patients. ( Angelo, HR; Blemmer, T; Christrup, LL; Drenck, NE; Kristensen, K; Rasmussen, SN; Sjøgren, P, 1996) |
| "Methadone is a very potent analgesic drug." | 2.68 | Pain perception of intravenous heroin users on maintenance therapy with levomethadone. ( Gastpar, M; Katta, T; Klöppel, A; Pries, E; Schall, U, 1996) |
| " After achieving adequate analgesia with regular dosing of oral methadone (T1), patient-controlled analgesia with methadone was administered for 3 days (T2)." | 2.68 | Opioid-sparing effect of diclofenac in cancer pain. ( Barresi, L; Caligara, M; Dardanoni, G; Mercadante, S; Sapio, M; Serretta, R, 1997) |
| "01) dipipanone and a dose-response relationship was evident." | 2.66 | Effects of an opiate on cold-induced pain and the CNS in healthy volunteers. ( Crowley, D; Peck, AW; Phillipson, R; Posner, J; Telekes, A, 1985) |
| "Methadone is a synthetic opioid analgesic with potential advantages over other commonly used opioids." | 2.53 | Methadone analgesia in the critically ill. ( Elefritz, JL; Lyaker, MR; Murphy, CV; Papadimos, TJ, 2016) |
| "Up to 44% of patients with cancer-related pain require opioid rotation (OR) because of inadequate analgesia or side effects." | 2.52 | Methods of Rotation From Another Strong Opioid to Methadone for the Management of Cancer Pain: A Systematic Review of the Available Evidence. ( McLean, S; Twomey, F, 2015) |
| "Older patients represent a challenge for physicians, as a further factor may play a role in dosing methadone and possibly on successful switching." | 2.48 | The effect of age on opioid switching to methadone: a systematic review. ( Bruera, E; Mercadante, S, 2012) |
| "Methadone was used subcutaneously as an analgesic agent in 1 patient." | 2.47 | Review of cancer pain management in patients receiving maintenance methadone therapy. ( McLean, S; McQuillan, R; O'Gorman, A; Rowley, D; Ryan, K, 2011) |
| "Methadone is an opioid analgesic that is also commonly used to prevent opioid-withdrawal symptoms in patients undergoing treatment for opioid addiction." | 2.47 | Methadone: marvelous, malevolent, or merely misunderstood? ( Martin, CM, 2011) |
| "Pharmacological approaches incorporate the continuation of usual medications (or equivalent), short-term use of sometimes much higher than average doses of additional opioid, and prescription of non-opioid and adjuvant drugs, aiming to improve pain relief and attenuate opioid tolerance and/or opioid-induced hyperalgesia." | 2.47 | Acute pain management in opioid-tolerant patients: a growing challenge. ( Huxtable, CA; MacIntyre, PE; Roberts, LJ; Somogyi, AA, 2011) |
| "Methadone also has a long elimination half-life (19 [SD 14] hours) and NMDA receptor activity although dose administration is complicated by highly variable morphine equianalgesic equivalence (1 : 2." | 2.45 | Pediatric palliative care: use of opioids for the management of pain. ( Anderson, BJ; Craig, F; Michel, E; Zernikow, B, 2009) |
| "Methadone is a long-acting synthetic opioid with high affinity for various opioid receptors, especially for m-opioid receptors." | 2.45 | [Methadone treatment and its dangers]. ( Jodziūniene, L; Lazauskas, R; Reingardiene, D, 2009) |
| "Up to 80% of people with cancer experience pain at some time during their illness, and most will need opioid analgesics." | 2.44 | Opioids in people with cancer-related pain. ( Quigley, C, 2008) |
| " This article reviews the World Health Organization recommendations for analgesic therapy in this setting, as well as guidelines for opioid therapy in patients with renal failure or hepatic failure, assessment of pain, dosing strategies in both acute and chronic pain, management of opioid overdose, pain associated with dose-limiting side effects, and pain in the actively dying." | 2.44 | Practical guide to opioids and their complications in managing cancer pain. What oncologists need to know. ( Davis, MP; Gamier, P; Lasheen, W, 2007) |
| "Pain is a multidimensional symptom that can overshadow all other experiences of both the child and family." | 2.44 | The management of pain in children with life-limiting illnesses. ( Friedrichsdorf, SJ; Kang, TI, 2007) |
| "Methadone is a synthetic opioid with potent analgesic effects." | 2.43 | Methadone treatment for pain states. ( Kral, LA; Toombs, JD, 2005) |
| "Undertreatment of acute pain is suboptimal medical treatment, and patients receiving long-term OAT are at particular risk." | 2.43 | Acute pain management for patients receiving maintenance methadone or buprenorphine therapy. ( Alford, DP; Compton, P; Samet, JH, 2006) |
| "Ongoing assessment, multiple approaches, and excellent communication among all care management team members are critical." | 2.43 | Difficult cases in pain management: use of methadone in a multifactorial approach. ( Coyle, N; Coyne, P; Griffie, J, 2006) |
| "Methadone is a unique mu opioid agonist, which also has delta receptor affinity and properties of N-methyl-D-aspartate receptor antagonism and monoamine reuptake inhibition." | 2.43 | Methadone for treatment of cancer pain. ( Bryson, J; Seccareccia, D; Tamber, A; Zimmermann, C, 2006) |
| " Regular pain assessments combined with appropriate analgesic administration at regular dosing intervals, adjunctive drug therapy for control of adverse effects and associated symptoms, and nonpharmacological interventions are recommended." | 2.42 | Cancer pain management in children. ( Mercadante, S, 2004) |
| "Methadone is a synthetic opioid, with mu and delta receptor activity, associated with the capacity to inhibit N-methyl-D-aspartate receptors." | 2.41 | Opioid switch to oral methadone in cancer pain. ( Body, JJ; Lossignol, DA; Mancini, I, 2000) |
| " When initiating treatment, controlled-release preparations of opioids are generally favoured, and are combined with immediate release morphine to prevent or treat 'breakthrough' pain and to enable the optimum opioid dosage to be calculated." | 2.41 | [Treatment of pain in cancer with systemically administered opioids]. ( de Wit, R; Enting, RH; Lieverse, PJ; Smitt, PA; van der Rijt, CC; Wilms, EB, 2001) |
| "Tramadol is a centrally acting analgesic drug; it has an agonist effect on mu 1 receptors of opioids and acts also by inhibiting the re-uptake of noradrenaline and serotonine which activates descending monoaminergic inhibitory pathways." | 2.40 | [Treatment of pain in oncology]. ( De Conno, F; Polastri, D, 1997) |
| "When pain is relieved inadequately by opioid analgesics given in a dose that causes intolerable side effects despite routine measures to control them, treatment with the same opioid by an alternative route or with an alternative opioid administered by the same route should be considered." | 2.40 | Opioid rotation for cancer pain: rationale and clinical aspects. ( Mercadante, S, 1999) |
| "Gabapentin exposure in treatment-seeking persons with OUD appears to be quite common, and use, both medically and nonmedically, frequently occurs alongside OAMs." | 1.91 | Understanding motivations and use typologies of gabapentin with opioid agonist medications. ( Buttram, ME; Ellis, MS; Qureshi, R, 2023) |
| "Methadone is an effective analgesic with unique pharmacokinetic and pharmacodynamic variables." | 1.91 | Comparing National Methadone Equianalgesic Tools. ( Atayee, RS; Edmonds, KP; Wen, RY, 2023) |
| ", i) the analgesic agent is identical to the OAT medication, and ii) the opioid agent is dosed above 1/6th morphine equivalent dose of the OAT medication." | 1.91 | Rescue Analgesia for Opioid-Dependent Individuals on Opioid Agonist Treatment during Hospitalization: Adherence to Guideline Treatment. ( Arnet, I; Dürsteler, KM; Grossmann, F; Hersberger, KE; Jaiteh, C, 2023) |
| " We aimed to assess the immediate effects of the methadone reformulation on missed doses, days off methadone, changes in medication dosing and dispensations of opioids for pain, and hospitalizations and mortality among all people receiving treatment at or near the time of the change." | 1.72 | The effect of a methadone reformulation on opioid agonist treatment outcomes: A population-based study in British Columbia, Canada, 2013-14. ( Dale, LM; Hongdilokkul, N; Krebs, E; Min, JE; Nosyk, B; Schnepel, KT; Shigeoka, H, 2022) |
| "Methadone is a long-acting analgesic that targets the N-methyl-D-aspartate (NMDA) receptor in addition to the mu opioid receptor and has benefit in adult burn patients." | 1.72 | Intraoperative Methadone Use in Pediatric Burn Patients. ( Ambardekar, A; Carlson, A; Iskander, I; Pham, D; Price, C; Reisch, J, 2022) |
| "Buprenorphine was initiated by 58% and 42% started methadone." | 1.72 | Factors associated with retention on medications for opioid use disorder among a cohort of adults seeking treatment in the community. ( Biondi, BE; Schlossberg, EF; Shaw, A; Springer, SA; Vander Wyk, B, 2022) |
| "Methadone doses were changed according to the clinical needs to obtain the most favorable balance between analgesia and adverse effects." | 1.72 | Methadone as First-line Opioid for the Management of Cancer Pain. ( Adile, C; Bonanno, G; Casuccio, A; Ferrera, P; Mercadante, S; Pallotti, MC; Ricci, M, 2022) |
| "Standard of care for opioid use disorder (OUD) includes medication and counseling." | 1.62 | A Virtual Reality Meditative Intervention Modulates Pain and the Pain Neuromatrix in Patients with Opioid Use Disorder. ( Bluth, MH; Faraj, MM; Goldberg, E; Greenwald, MK; Lipanski, NM; Marusak, HA; Morales, A, 2021) |
| "Methadone 45 mg per day was effective in alleviating his pain, but he experienced severe drowsiness following trabectedin induced liver injury." | 1.51 | [A Case of Methadone Induced Drowsiness Following Trabectedin Induced Liver Injury]. ( Higuchi, M; Ishiki, H; Kiuchi, D; Satomi, E; Shimizu, M, 2019) |
| "Treating patients with opioid use disorder (OUD) and traumatic brain injury illustrates 6 neurobiological principles about the actions of 2 contrasting opioid analgesics, morphine and fentanyl, as well as pharmacotherapies for OUD, methadone, naltrexone, and buprenorphine." | 1.48 | Neurobiology of Opioid Use Disorder and Comorbid Traumatic Brain Injury. ( Graham, DP; Kosten, TR; Nielsen, DA, 2018) |
| "In methadone-treated OD subjects drawn from a case and control sample, we conducted a genome-wide association study of usual daily methadone dose." | 1.46 | Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. ( Cook-Sather, SD; Farrer, LA; Gelernter, J; Hakonarson, H; Jensen, KP; Kranzler, HR; Li, J; Nunez, Y; Smith, AH, 2017) |
| "The aim of the study was to evaluate the tolerability, sedative and analgesic effects of methadone in combination with medetomidine for premedication prior to neutering in healthy cats." | 1.42 | Methadone in combination with medetomidine as premedication prior to ovariohysterectomy and castration in the cat. ( Bortolami, E; Murrell, JC; Slingsby, LS, 2015) |
| "While opioid dependence is a complex health condition, the treatment of HIV-infected individuals with opioid dependence presents additional challenges." | 1.42 | HIV-gp120 and physical dependence to buprenorphine. ( Abood, ME; Benamar, K; Palma, J, 2015) |
| "In methadone treated cats there was no significant variation in MNT over time, suggesting a possible anti-hyperalgesic action, whereas in the other two groups lower thresholds were recorded at various time points after surgery compared to baseline." | 1.39 | Methadone in combination with acepromazine as premedication prior to neutering in the cat. ( Bortolami, E; Murrell, JC; Slingsby, LS, 2013) |
| " Here, we examined whether moderate doses of methadone carry any benefits over chronic use of equianalgesic morphine, the prototypical opioid." | 1.38 | Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice. ( Enquist, J; Ferwerda, M; Milan-Lobo, L; Whistler, JL, 2012) |
| "The methadone was obtained by illegal diversion (sale, gift, or theft) in 67% of cases." | 1.37 | The methadone epidemic: methadone-related deaths on the rise in Vermont. ( Madden, ME; Shapiro, SL, 2011) |
| " In the switching study DDD indicated a reduction in analgesic dosing and OMEQ an increase when switching from WHO step II to III." | 1.37 | Choosing the unit of measurement counts: the use of oral morphine equivalents in studies of opioid consumption is a useful addition to defined daily doses. ( Borchgrevink, P; Dale, O; Fredheim, O; Hamunen, K; Mellbye, A; Svendsen, K, 2011) |
| "Buprenorphine thus appears to be a more effective analgesic than methadone in the presence of gp120 in the brain, a condition that is associated with HIV-related pain and infection." | 1.37 | Differential antinociceptive effects of buprenorphine and methadone in the presence of HIV-gp120. ( Adler, MW; Benamar, K; Cowan, A; Geller, EB; Palma, J, 2011) |
| "Since this operation a recurrence of the displacement has not been observed and consecutively the filling of the pump could be accomplished without radiological investigations." | 1.36 | [Displaced pain pump because of a pendulous abdomen - dermatolipectomy as solution of the problem]. ( Föhn, M; Oehy, K; Vetter, M; Wedler, V, 2010) |
| "Injection users are at risk for vascular injuries resulting in chronic venous disease (CVD)." | 1.36 | Injection-related venous disease and walking mobility. ( Birk, TJ; Kirsner, RS; Pieper, B; Templin, TN, 2010) |
| "Pain is an important and often under-treated symptom of life-threatening illness." | 1.35 | [Analgesics and palliative care]. ( Mathieu, N; Tuna, T, 2008) |
| "This is a case report of a CPP treated by a pain physician." | 1.35 | Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report. ( Cole, B; Fishbain, DA; Gao, J; Lewis, JE; Rosomoff, RS, 2009) |
| "7), which approximates the bioavailability of the drug administered orally." | 1.35 | Conversion from parenteral to oral methadone. ( Gómez-Batiste, X; González-Barboteo, J; Porta-Sales, J; Sánchez, D; Tuca, A, 2008) |
| "Cancer pain is common, occurring in up to 60% of patients and opioid conversion may be required for effective pain management." | 1.35 | Inconsistencies in opioid equianalgesic ratios: clinical and research implications. ( Kutner, JS; Linnebur, SA; O'Bryant, CL; Yamashita, TE, 2008) |
| "Methadone was used (71." | 1.35 | Prescription opioid use, misuse, and diversion among street drug users in New York City. ( Davis, WR; Johnson, BD, 2008) |
| "Methadone is an interesting analgesic for multiple reasons." | 1.35 | The safety of methadone hydrochloride. ( Swegle, JM; Wensel, DD, 2008) |
| "The challenge is not in treating pain, but identifying true pain from drug-seeking behaviors." | 1.35 | Chronic pain in patients with substance abuse disorder: general guidelines and an approach to treatment. ( Dewey, CM; Mitchell, AM, 2008) |
| "Neuropathic pain is associated with several sensory abnormalities, including allodynia as well as spontaneous pain." | 1.34 | Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. ( Buechler, NL; Eisenach, JC; Kim, SA; Martin, TJ; Porreca, F, 2007) |
| " In addition, methadone dosage requirements were not influenced by CYP2D6 genotypes in these subjects." | 1.34 | Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone. ( Christrup, L; Coller, JK; Foster, DJ; Gillis, D; James, H; Joergensen, C; Somogyi, AA, 2007) |
| "(1) Methadone is an opiate used for replacement therapy of opiate addiction that causes dose-dependent QT prolongation." | 1.33 | Torsades de pointes with methadone. ( , 2005) |
| "Methadone daily dosage was also analyzed during this study." | 1.32 | Methadone and the hospice patient: prescribing trends in the home-care setting. ( Alt, CJ; Gallagher, R; Knowlton, CH; McMath, JA; Weschules, DJ, 2003) |
| "Pain was associated with an increased propensity for misuse of substances with analgesic effects, suggesting that ongoing pain contributes to an altered and more severe pattern of drug-seeking behavior." | 1.32 | Treatment needs associated with pain in substance use disorder patients: implications for concurrent treatment. ( Horst, DA; Humphreys, K; Minkel, JD; Oliva, EM; Trafton, JA, 2004) |
| "In patients with a history of substance abuse, these are often serious developments to which a clinician must know how to react." | 1.32 | Opioid therapy in patients with a history of substance abuse. ( Kirsh, KL; Passik, SD, 2004) |
| "Methadone is a widely used synthetic opioid which is administered as a racemic mixture of (R)-(--)- and (S)-(+)-enantiomers, with only (R)-(--)-methadone possessing mu opioid receptor agonist activity." | 1.32 | (S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone. ( Hutchinson, MR; Somogyi, AA, 2004) |
| "Methadone has been reported to improve pain relief in patients with morphine resistance, and it is lipophilic and exerts a lesser activity on opioid receptors in the gastrointestinal tract." | 1.31 | Methadone in treatment of tenesmus not responding to morphine escalation. ( Dabbene, M; Fulfaro, F; Mercadante, S, 2001) |
| "To assess the effect of opioid substitution (substituting one member of the opioid class for another) on the incidence and severity of adverse effects in palliative care patients who experience unacceptable, refractory adverse effects when taking an opioid drug." | 1.30 | Opioid substitution to reduce adverse effects in cancer pain management. ( Ashby, MA; Jackson, KA; Martin, P, 1999) |
| "Methadone dose was significantly higher in patients who had lower preswitching doses of morphine and vice versa." | 1.30 | Rapid switching from morphine to methadone in cancer patients with poor response to morphine. ( Calderone, L; Casuccio, A; Mercadante, S, 1999) |
| "Twenty patients with end-stage head and neck cancer, unresponsive to either acetaminophen with codeine or oxycodone hydrochloride, were placed on a four-drug analgesic regimen consisting of methadone hydrochloride, Trilisate or acetaminophen, a tricyclic antidepressant, and, in most cases, hydroxyzine." | 1.29 | A four-drug pain regimen for head and neck cancers. ( Carrol, EN; Fine, E; Ruff, RL; Stepnick, D, 1994) |
| "Methadone is a synthetic opioid with excellent oral bioavailability, variable, but long duration of action and extremely low cost." | 1.29 | Respiratory depression in a patient receiving oral methadone for cancer pain. ( Bruera, E; Hunt, G, 1995) |
| " Drug intervention should be on a regular schedule--avoid prn dosage of pain medications." | 1.27 | Dilemmas in managing prostate carcinoma (Part II): Metastatic disease. ( Ahmann, FR, 1985) |
| "Morphine and methadone were found to produce both quantal and graded effects in all experiments." | 1.27 | The graded and quantal nature of opioid analgesia in the rat tailflick assay. ( Cohen, A; Inturrisi, CE; Ling, GS; Umans, JG; Yoburn, BC, 1985) |
| "If pain is in the trigeminal nerve distribution, local nerve block procedures may provide additional relief." | 1.26 | Pain control in advanced and recurrent head and neck cancer. ( McCann, CF; Scott, RM; Shapshay, SM; Stoelting, I, 1980) |
| " Long-term use of analgesic drugs in chronic pain usually produces negative behavioral complications that are more difficult to manage than the pain it was desired to eliminate." | 1.26 | Analgesic drugs in the management of pain. ( Halpern, LM, 1977) |
| " Evidence of tolerance was indicated by the fact that when the antinociceptive response to morphine was assessed by the hot-plate and the tail-flick procedures, a shift in the dose-response curve of morphine to the right occurred after an adequate single priming dose of morphine." | 1.26 | Studies on tolerance development to single doses of morphine in mice. ( Huidobro, F; Huidobro-Toro, JP; Leong Way, E, 1976) |
| "Methadone is an effective analgesic whose pharmacokinetics must be appreciated in order for it to be used safely and effectively." | 1.26 | Important clinical pharmacologic considerations in the use of methadone in cancer patients. ( Ettinger, DS; Trump, DL; Vitale, PJ, 1979) |
| "Xylazine was significantly more effective in obtunding deep pain (P less than 0." | 1.26 | Objective tests of analgesic drugs in ponies. ( Lumb, WV; Pippi, NL, 1979) |
| " Unit dose packaging is used because the oral solid dosage forms (including placebos) are made to look alike." | 1.25 | Drug use and distribution in a pain rehabilitation center. ( Beckner, TF; Idsvoog, P, 1975) |
Research
Studies (480)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 84 (17.50) | 18.7374 |
| 1990's | 47 (9.79) | 18.2507 |
| 2000's | 183 (38.13) | 29.6817 |
| 2010's | 130 (27.08) | 24.3611 |
| 2020's | 36 (7.50) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Galt, RH | 1 |
| Horbury, J | 1 |
| Matusiak, ZS | 1 |
| Pearce, RJ | 1 |
| Shaw, JS | 1 |
| Dufort, A | 1 |
| Samaan, Z | 1 |
| Komrowski, MD | 1 |
| Sekhri, NK | 1 |
| Treillet, E | 1 |
| Giet, O | 1 |
| Picard, S | 1 |
| Laurent, S | 1 |
| Seresse, L | 1 |
| Krebs, E | 1 |
| Hongdilokkul, N | 1 |
| Dale, LM | 1 |
| Min, JE | 1 |
| Schnepel, KT | 1 |
| Shigeoka, H | 1 |
| Nosyk, B | 1 |
| Ozberk, D | 1 |
| Haywood, A | 3 |
| Sutherland, HG | 1 |
| Yu, C | 1 |
| Albury, CL | 1 |
| Zunk, M | 1 |
| George, R | 2 |
| Good, P | 3 |
| Griffiths, LR | 1 |
| Hardy, J | 3 |
| Haupt, LM | 1 |
| Carlson, A | 1 |
| Pham, D | 1 |
| Price, C | 1 |
| Reisch, J | 1 |
| Iskander, I | 1 |
| Ambardekar, A | 1 |
| Biondi, BE | 1 |
| Vander Wyk, B | 1 |
| Schlossberg, EF | 1 |
| Shaw, A | 1 |
| Springer, SA | 1 |
| Mercadante, S | 24 |
| Adile, C | 5 |
| Ferrera, P | 7 |
| Pallotti, MC | 1 |
| Ricci, M | 1 |
| Bonanno, G | 1 |
| Casuccio, A | 9 |
| Wilson, M | 1 |
| Bindler, RJ | 1 |
| Stanek, K | 1 |
| Layton, ME | 1 |
| Quock, RM | 1 |
| Wallen, TE | 1 |
| Elson, NC | 1 |
| Singer, KE | 1 |
| Hayes, HV | 1 |
| Salvator, A | 1 |
| Droege, CA | 1 |
| Nomellini, V | 1 |
| Pritts, TA | 1 |
| Goodman, MD | 1 |
| Haas, MF | 1 |
| Latchman, J | 1 |
| Guastella, AM | 1 |
| Craig, DS | 1 |
| Chang, YD | 1 |
| Esposito, DB | 1 |
| Huybrechts, KF | 2 |
| Werler, MM | 1 |
| Straub, L | 1 |
| Hernández-Díaz, S | 2 |
| Mogun, H | 2 |
| Bateman, BT | 2 |
| Ellis, MS | 3 |
| Qureshi, R | 3 |
| Buttram, ME | 3 |
| Grassi, Y | 1 |
| Cascio, AL | 2 |
| Thakrar, AP | 1 |
| Uritsky, TJ | 1 |
| Christopher, C | 1 |
| Winston, A | 1 |
| Ronning, K | 1 |
| Sigueza, AL | 1 |
| Caputo, A | 1 |
| McFadden, R | 1 |
| Olenik, JM | 1 |
| Perrone, J | 1 |
| Delgado, MK | 1 |
| Lowenstein, M | 1 |
| Compton, P | 4 |
| Wen, RY | 1 |
| Edmonds, KP | 2 |
| Atayee, RS | 3 |
| Reynolds-Wright, JJ | 1 |
| Morroni, C | 1 |
| Woldetsadik, MA | 1 |
| Cameron, ST | 1 |
| Wong, ML | 1 |
| Achu, RA | 1 |
| Spence, NZ | 1 |
| White, KO | 1 |
| Hughto, JMW | 1 |
| Tapper, A | 1 |
| Rapisarda, SS | 1 |
| Stopka, TJ | 1 |
| Palacios, WR | 1 |
| Case, P | 1 |
| Silcox, J | 1 |
| Moyo, P | 1 |
| Green, TC | 1 |
| Arnet, I | 1 |
| Dürsteler, KM | 1 |
| Jaiteh, C | 1 |
| Grossmann, F | 1 |
| Hersberger, KE | 1 |
| Pan, S | 1 |
| Anderson, TA | 1 |
| Ledlie, S | 1 |
| Tadrous, M | 1 |
| McCormack, D | 1 |
| Campbell, T | 1 |
| Leece, P | 1 |
| Kleinman, RA | 1 |
| Kolla, G | 1 |
| Besharah, J | 1 |
| Smoke, A | 1 |
| Sproule, B | 2 |
| Gomes, T | 1 |
| De Aquino, JP | 1 |
| Meyerovich, J | 1 |
| Xie, CZ | 1 |
| Ranganathan, M | 1 |
| Pittman, B | 1 |
| Rogan, M | 1 |
| Sofuoglu, M | 1 |
| Kerr, CL | 1 |
| Swanton, WE | 1 |
| Makunts, T | 1 |
| U, A | 1 |
| Abagyan, R | 1 |
| Smith, MA | 1 |
| Quirk, KC | 1 |
| Saul, DC | 1 |
| Rodgers, PE | 1 |
| Silveira, MJ | 1 |
| Hermann, GM | 1 |
| Iovoli, AJ | 1 |
| Platek, AJ | 1 |
| Wang, C | 1 |
| Miller, A | 1 |
| Attwood, K | 1 |
| Bourgeois, DJ | 1 |
| Singh, AK | 1 |
| McPherson, ML | 3 |
| Wendling, AL | 1 |
| Garvan, C | 1 |
| Roussos-Ross, D | 1 |
| Zhang, L | 1 |
| Zeng, D | 1 |
| Morie, KP | 1 |
| Potenza, MN | 1 |
| Beitel, M | 4 |
| Oberleitner, LM | 1 |
| Roos, CR | 1 |
| Yip, SW | 1 |
| Oberleitner, DE | 1 |
| Gaeta, M | 1 |
| Barry, DT | 4 |
| Amon, T | 1 |
| Kästner, SBR | 1 |
| Kietzmann, M | 1 |
| Tünsmeyer, J | 1 |
| Faraj, MM | 1 |
| Lipanski, NM | 1 |
| Morales, A | 1 |
| Goldberg, E | 1 |
| Bluth, MH | 1 |
| Marusak, HA | 1 |
| Greenwald, MK | 1 |
| Furst, JA | 1 |
| Mynarski, NJ | 1 |
| McCall, KL | 1 |
| Piper, BJ | 1 |
| Biewald, MA | 1 |
| Scarborough, B | 1 |
| Lindenberger, E | 1 |
| Faul, M | 1 |
| Bohm, M | 1 |
| Alexander, C | 1 |
| Hoff, AM | 1 |
| Hartwig, KN | 1 |
| Rosielle, DA | 1 |
| Nordmann, S | 1 |
| Vilotitch, A | 1 |
| Lions, C | 1 |
| Michel, L | 1 |
| Mora, M | 1 |
| Spire, B | 2 |
| Maradan, G | 1 |
| Bendiane, MK | 1 |
| Morel, A | 1 |
| Roux, P | 2 |
| Carrieri, P | 1 |
| Karimian, P | 1 |
| Ajayi, TA | 1 |
| Yang, YJ | 1 |
| Xu, YM | 1 |
| Chen, WC | 1 |
| Zhu, JH | 1 |
| Lu, J | 1 |
| Zhong, BL | 1 |
| Hennig, S | 1 |
| Khan, S | 2 |
| Norris, R | 1 |
| Zhou, K | 1 |
| Jia, P | 1 |
| Bhargava, S | 1 |
| Zhang, Y | 2 |
| Reza, T | 1 |
| Peng, YB | 1 |
| Wang, GG | 1 |
| Adam, VN | 1 |
| Matolić, M | 1 |
| Stojčić, EG | 1 |
| Mršić, V | 1 |
| Rašić, Ž | 1 |
| Cone, K | 1 |
| Lanpher, J | 1 |
| Kinens, A | 1 |
| Richard, P | 1 |
| Couture, S | 1 |
| Brackin, R | 1 |
| Payne, E | 1 |
| Harrington, K | 1 |
| Rice, KC | 2 |
| Stevenson, GW | 1 |
| Nnoli, A | 1 |
| Seligman, NS | 1 |
| Dysart, K | 1 |
| Baxter, JK | 1 |
| Ballas, SK | 1 |
| Kosten, TR | 3 |
| Graham, DP | 1 |
| Nielsen, DA | 1 |
| Costantino, RC | 1 |
| McPherson, AL | 1 |
| Voon, P | 1 |
| Greer, AM | 1 |
| Amlani, A | 1 |
| Newman, C | 1 |
| Burmeister, C | 1 |
| Buxton, JA | 1 |
| Goldschmidt, AB | 1 |
| Cotton, BP | 1 |
| Mackey, S | 1 |
| Laurent, J | 1 |
| Bryson, WC | 1 |
| Bond, DS | 1 |
| Gozalo-Marcilla, M | 1 |
| de Oliveira, AR | 1 |
| Fonseca, MW | 1 |
| Possebon, FS | 1 |
| Pelligand, L | 1 |
| Taylor, PM | 3 |
| Luna, SPL | 1 |
| Walker, KA | 1 |
| Davis, MP | 4 |
| Bruera, E | 20 |
| Reddy, A | 2 |
| Paice, J | 1 |
| Malotte, K | 1 |
| Lockman, DK | 1 |
| Wellman, C | 1 |
| Salpeter, S | 1 |
| Bemben, NM | 1 |
| Ray, JB | 1 |
| Lapointe, BJ | 1 |
| Chou, R | 1 |
| Chalker, C | 1 |
| O'Neill, H | 1 |
| Cranfield, F | 1 |
| Friedrichsdorf, SJ | 2 |
| Shimizu, M | 1 |
| Higuchi, M | 1 |
| Ishiki, H | 1 |
| Kiuchi, D | 1 |
| Satomi, E | 1 |
| Valle, A | 1 |
| Agnelotti, C | 1 |
| Caruselli, A | 1 |
| Moody, DE | 1 |
| Latuga, NM | 1 |
| Wahler, RG | 1 |
| Abadie, JM | 1 |
| Nyamathi, A | 1 |
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Clinical Trials (30)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Descriptive, Prospective Study of the Characteristics of Chronic Pain in Patients With Addiction to at Least One Substance[NCT05976178] | 300 participants (Anticipated) | Observational | 2022-12-10 | Recruiting | |||
| Investigation of Pharmacokinetics and Pharmacodynamics of Epidural Methadone in Healthy Volunteers[NCT03525509] | Early Phase 1 | 13 participants (Actual) | Interventional | 2018-06-04 | Completed | ||
| The Effect of Methadone vs. Fentanyl Administration on Postoperative Pain Control in Pediatric Patients Undergoing Cardiac Surgery: A Randomized, Double-Blinded Controlled Trial[NCT02747875] | 26 participants (Actual) | Interventional | 2016-09-30 | Terminated (stopped due to Drug Shortage) | |||
| Methadone in Pediatric and Adult Sickle Cell Patients[NCT00761085] | 47 participants (Actual) | Interventional | 2008-01-01 | Completed | |||
| Prospective Randomized Simple Blinded Study Comparing Two Conversion Ratios From Parenteral to Oral Methadone in Patients With Cancer Pain.[NCT01836328] | Phase 3 | 44 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Influence of Aging on Perioperative Methadone Dosing[NCT04526236] | Phase 4 | 60 participants (Actual) | Interventional | 2019-09-03 | Completed | ||
| Randomized Double-blind Controlled Study to Assess the Efficacy of Intravenous Acetaminophen Associated With Strong Opioids in the Management of Acute Pain in Adult Cancer Patients[NCT04779567] | Phase 4 | 112 participants (Actual) | Interventional | 2019-06-10 | Completed | ||
| Effect of Opioid Taper on Pain Responses in Patients With Chronic Pain[NCT03912298] | 7 participants (Actual) | Observational | 2019-04-15 | Completed | |||
| The Norwegian Addiction, Pain and Trauma Study[NCT04908410] | 1,500 participants (Anticipated) | Observational | 2021-03-23 | Recruiting | |||
| Evaluation of the Efficacy and Mechanisms of a Novel Intervention for Chronic Pain Tailored to People Living With HIV[NCT03692611] | 280 participants (Actual) | Interventional | 2019-08-14 | Active, not recruiting | |||
| Switching From Morphine to Methadone. A Clinical, Pharmacological and Pharmacogenetic Study[NCT00184496] | Phase 3 | 42 participants (Actual) | Interventional | 2004-08-31 | Completed | ||
| A Double Blind, Randomized Clinical Trial Comparing Postoperative Narcotic Usage in Patients Receiving Periarticular Liposomal Bupivicaine vs. Those Patients Receiving Standard Periarticular Joint Injections[NCT02682498] | Phase 4 | 38 participants (Actual) | Interventional | 2013-10-31 | Completed | ||
| Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone in Human Subjects[NCT00504413] | Phase 1 | 20 participants (Anticipated) | Interventional | 2007-07-31 | Recruiting | ||
| An Open-label, Randomised Pilot Study Comparing the Efficacy, Safety and Tolerability of Raltegravir With Protease Inhibitor-based Therapy in Treatment-naïve, HIV/Hepatitis C Co-infected Injecting Drug Users Receiving Methadone[NCT01105611] | Phase 4 | 40 participants (Anticipated) | Interventional | 2010-08-31 | Recruiting | ||
| Methadone for 'Adenocarcinopathic' Pain Treatment: Methadone vs. Morphine Vanguard RCT[NCT05325164] | Phase 3 | 0 participants (Actual) | Interventional | 2022-09-30 | Withdrawn (stopped due to Trial not started; change in Sponsor and Principal Investigator, trial to be registered again by new Sponsor/Investigator if it is started.) | ||
| Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain: A Randomized, Double-Blind Study[NCT00525967] | Phase 2/Phase 3 | 50 participants (Anticipated) | Interventional | 2006-02-28 | Recruiting | ||
| Pomegranate Juice Consumption by Patients Under Medication for Addiction Treatment as a Regulator of Craving and Blood Redox Status: The Study Protocol of a Randomized Control Trial (the NUTRIDOPE Study)[NCT05861544] | 58 participants (Anticipated) | Interventional | 2023-03-23 | Enrolling by invitation | |||
| Does Intraoperative Methadone Prevent Postoperative Pain in Bariatric Surgery?[NCT02775474] | Phase 4 | 32 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Evaluating the Use of Sublingual Sufentanil in Patients With Suboxone Treatment Who Are Undergoing Ambulatory Surgery- a Case Series[NCT04716413] | Phase 4 | 3 participants (Actual) | Interventional | 2021-09-27 | Terminated (stopped due to Terminated early due to funding, lack of participants) | ||
| Single-dose Intraoperative Methadone for Early Ambulation and Sustained Pain Control in Spinal Fusion Surgery Patients[NCT02989597] | Phase 4 | 10 participants (Actual) | Interventional | 2017-07-29 | Terminated (stopped due to Due to personnel loss and logistical issues the study was unable to be completed as planned.) | ||
| Opioid Switching From Oral Slow Release Morphine to Oral Methadone May Improve Pain Control in Chronic Non-malignant Pain: a Nine-month Follow-up Study.[NCT00356083] | Phase 3 | 12 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| Behavioral Intervention to Improve Insomnia Symptoms in Patients With Opioid Use Disorder[NCT05588726] | 0 participants (Actual) | Interventional | 2022-01-01 | Withdrawn (stopped due to Staff no longer available to continue enrollment and other research activities) | |||
| The Effect of Acute Intravenous Morphine Administration on Sleep Disordered Breathing (SDB) in Patients With Moderate Obstructive Sleep Apnoea (OSA): A Paired Design Trial[NCT03127800] | Phase 3 | 6 participants (Actual) | Interventional | 2016-05-20 | Terminated (stopped due to Difficulties with recruitment) | ||
| A Randomized Blinded Prospective Trial Comparing Single Intraoperative Dose of Methadone Versus Placebo in Pediatric Patients Undergoing Spine Surgery.[NCT02206685] | Phase 4 | 74 participants (Actual) | Interventional | 2014-05-31 | Completed | ||
| Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management[NCT02335398] | Phase 4 | 34 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| IRB-HSR# 14145 R,S Methadone: Analgesia and Pharmacokinetics in Adolescents Undergoing Scoliosis Correction[NCT01205256] | Phase 3 | 11 participants (Actual) | Interventional | 2009-03-31 | Completed | ||
| Study of the Efficiency of the Ketamine With Low Analgesic Doses, in Association With High Opioids, in the Treatment of the Rebels Pains, in Palliative Phase of the Cancerous Disease[NCT01326325] | Phase 3 | 24 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| Effect of Beta Blockade on Opioid-Induced Hyperalgesia in Humans[NCT01222091] | Phase 2 | 10 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| The Effects of Opioid Taper on Opioid-Induced Hyperalgesia[NCT03063905] | 15 participants (Actual) | Observational | 2017-01-31 | Terminated (stopped due to funding expired) | |||
| Intraoperative Methadone Versus Morphine for Postoperative Pain Control in Patients Undergoing Intramedullary Nailing or Open Reduction and Internal Fixation of the Tibia[NCT01430182] | 17 participants (Actual) | Interventional | 2011-09-30 | Terminated (stopped due to Shortages of study drug, difficulty enrolling patients) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Total Opioid Dose, in Morphine Equivalents, in the First 24 Hours After Pediatric Cardiac Bypass Surgery.
The distribution of the total opioid dose in the first 24 hours will be evaluated by randomization group (methadone vs. fentanyl) and differences between groups will be tested. It is hypothesized that compared to fentanyl, methadone administered intraoperative will result in a significantly lower total opioid dose (morphine or oxycodone) during the first 24 hour postoperative period. Assuming no difference between the two treatment strategies in the population, a total sample size of 52 in each group will provide 80% power to detect an effect size of 0.1. Significance will be measured as a 30% reduction in postoperative pain requirement. (NCT02747875)
Timeframe: 24 hours
| Intervention | mg postop morphine equivelant 24hr (Mean) |
|---|---|
| Control - Fentanyl | 0.55 |
| Treatment - Methadone | 0.48 |
Opioid-related Adverse Events Including: Respiratory Failure, Cardiovascular Instability, and Postoperative Nausea and Vomiting
Opioid-related adverse events will be monitored closely and a secondary analysis will compare the incidence of side effects between the two groups during the first 24-hour postoperative period. The Pearson's contingency chi-square test will be used to evaluate any differences between the randomization groups in opioid-related adverse events during the first 24-hour postoperative period. (NCT02747875)
Timeframe: 24 hours
| Intervention | events (Mean) | |||
|---|---|---|---|---|
| Ondansetron Doses | Emesis Episodes | Hypoventilation Episodes | Arrhythmias | |
| Control - Fentanyl | 3.81 | 2.72 | 0 | 0 |
| Treatment - Methadone | 3.43 | 2.08 | 0 | 0 |
Pain Relief
Pain relief score using the 10CM VAS, which has a pain scale of 0-10, with 0=no pain and 10=worst pain experienced (NCT00761085)
Timeframe: 72 hr
| Intervention | units on a scale (Mean) |
|---|---|
| Methadone-Children | 8 |
| Morphine-Children | 4 |
| Methadone-Adults | 5 |
| Morphine-Adults | 5 |
To Determine the Pharmacokinetics of Methadone in Children and Adults With Sickle Cell Disease Experiencing a VOE.
R-Methadone AUC (NCT00761085)
Timeframe: 96 hr
| Intervention | (hr*ng/ml) (Mean) |
|---|---|
| Methadone-Children | 523 |
| Morphine-Children | 0 |
| Methadone-Adults | 637 |
| Morphine-Adults | 0 |
Conditioned Pain Modulation Measured Using the Quantitative Sensory Testing (QST)
Conditioned pain modulation will be measured using the quantitative sensory testing (QST) employing procedures consistent with those described in the literature to capture supra-spinal mechanisms of OIH. To detect conditioned modulation, the subject is asked to verbally report the severity of pain experienced on a visual analogue scale (0- no pain, 10-worst pain ever) to a three-second painful heat stimulus (47○C) delivered at 12-15 second intervals, in the presence or absence of the non-dominant limb being immerged in a cold-water bath (12○C). The reported value is the difference between the average of pain scores reported in the absence of vs. the presence of the counter-stimulation. Reported are changes in the conditioned pain modulation assay both prior to and following taper. Taper is individualized thus length of taper varies between subjects. (NCT03912298)
Timeframe: up to one year (individualized, variable taper length)
| Intervention | units on a visual analogue scale (Mean) | |
|---|---|---|
| pre-taper conditioned pain modulation (baseline) | post taper conditioned pain modulation (individualized taper, thus time length varies) | |
| Chronic Pain Patients Undergoing Opioid Taper | -0.14 | -0.40 |
Pain Perception Measured Using the Cold-pressor Test (CPT)
Pain perception will be measured using the cold-pressor test (CPT) employing procedures consistent with those described in the literature. Order of pain testing will vary, and three aspects of the pain response will be captured at each study session: evoked pain; temporal summation; and conditioned pain modulation, which map on to the hypothesized peripheral, spinal and supra-spinal mechanisms of OIH. Reported are cold-pressor pain tolerance prior to and following taper. (NCT03912298)
Timeframe: up to one year (length of taper individualized and varies)
| Intervention | seconds (Mean) | |
|---|---|---|
| pre taper pain tolerance (baseline) | post-taper pain tolerance (timeframe variable) | |
| Chronic Pain Patients Undergoing Opioid Taper | 24.01 | 42.02 |
48 Hour Post-surgical Opioid Use
A comparison of group means between the control group and study group with regards to 48 hour opioid use. (NCT02682498)
Timeframe: 48 hours
| Intervention | morphine equivalents (Mean) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 5.32 |
| Standard Periarticular Joint Injection | 5.07 |
Average Daily Opioid Use During Admission
Opioid use will be monitored daily from the time of admission in comparison of standard knee injection post-operatively. (NCT02682498)
Timeframe: Up to 48 hours
| Intervention | Total Morphine Equivalents (Mean) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 100 |
| Standard Periarticular Joint Injection | 103 |
Average Daily Patient Pain Score
Examining the average daily patient pain score in comparison of standard knee injection post-operatively. The measure is the Visual-Analog-Scale (VAS) for subjective pain reporting. The minimum 0 (no pain) and the maximum is 10 (worst pain imagineable). There is only one measure in the scale (i.e. there are no subscales). Lower scores on the VAS scale equate to less pain and are therefore desirable. (NCT02682498)
Timeframe: Up to 48 hours
| Intervention | Visual Analog Scale Rating (Mean) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 4.75 |
| Standard Periarticular Joint Injection | 5.75 |
Post-operative Complications
Examining the post-operative complication in comparison of standard knee injection post-operatively. (NCT02682498)
Timeframe: Up to 1 month
| Intervention | complications (Number) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 0 |
| Standard Periarticular Joint Injection | 0 |
Recovery Room Opioid Use
Post anesthesia care unit (recovery room) opioid use in total mg morphine IV equivalent in comparison of standard knee injection post-operatively. (NCT02682498)
Timeframe: Up to 48 hours
| Intervention | Total morphine equivalents (Median) |
|---|---|
| EXPAREL® Bupivacaine Liposome Suspension | 5 |
| Standard Periarticular Joint Injection | 5 |
Opioid Usage
Subjects were given access to Patient-Controlled Intravenous Opioid Administration (PCA) to manage their post-operative pain. The doses of morphine were calculated at at PACU, 24 hours, 48 hours and 72 hours respectively. (NCT02206685)
Timeframe: Admission to PACU to 72 hours post-operative
| Intervention | mg/kg (Median) | |||
|---|---|---|---|---|
| PACU | 24 Hours | 48 Hours | 72 Hours | |
| Control Group | 0.47 | 0.55 | 0.55 | 0.04 |
| Treatment Group | 0.41 | 0.58 | 0.58 | 0.10 |
Pain Scores
The FLACC scale or Face, Legs, Activity, Cry, Consolability scale is a measurement used to assess pain for children between the ages of 2 months and 7 years or individuals that are unable to communicate their pain. The scale is scored in a range of 0-10 with 0 representing no pain. The scale has five criteria, which are each assigned a score of 0, 1 or 2. The data reported here represents the mean difference in FLACC score by treatment group at PACU, 24 hours, 48 hours and 72 hours, respectively. (NCT02206685)
Timeframe: Admission to PACU to 72 hours post-operative
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| PACU | 24 Hours | 48 Hours | 72 Hours | |
| Control Group | 0.65 | 0.42 | 0.36 | 0.29 |
| Treatment Group | 0.53 | 0.14 | 0.24 | 0.16 |
Objective Opioid Withdrawal Scale (OOWS)
OOWS: Is a 13-item instrument of documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score = 13, minimum score = 0. Lower scores correspond to fewer symptoms. (NCT01222091)
Timeframe: Pretreatment [90 min prior to 60-min REM infusion]; 30 min prior to 60-min REM infusion; 15 and 40 min after start of 60-min REM infusion; 5, 15, and 75 minutes after finish of 60-min REM infusion)
| Intervention | units on a scale (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| Pretreatment | 30 min prior to REM infusion | 15 min after start of REM infusion | 40 min after start of REM infusion | 5 minutes after finish of REM infusion | 15 minutes after finish of REM infusion | 75 minutes after finish of REM infusion | |
| Placebo | 1.1 | 1.1 | 0.8 | 0.5 | 1.8 | 2.1 | 1.6 |
| Propranolol | 1.2 | 1.1 | 0.1 | 0.8 | 3 | 2.8 | 1.7 |
Percent Change From Baseline in Size (Area) of Secondary Hyperalgesia After Cessation of Remifentanil Infusion, a Measure of Opioid-induced Hyperalgesia (OIH).
A slightly modified version of a previously described model of secondary hyperalgesia was used. Two copper wires contained in a microdialysis catheter were inserted in parallel over a length of 5 mm into the dermis of the right volar forearm. The wires were connected to a constant current stimulator controlled by a pulse generator to deliver rectangular and monophasic pulses with a duration of 0.5 mg at 2 Hz. Over a period of 15 min, the current was increased by targeting a pain rating of 5 on an 11-point numeric rating scale (0 = no pain and 10 = maximum tolerable pain) until the hyperalgesic area surrounding the stimulation site was fully established. Once the area was established, the current was held constant. Percent change from baseline in size (area) of secondary hyperalgesia after cessation of remifentanil infusion was calculated per group. (NCT01222091)
Timeframe: Baseline; 15 min post remifentanil (REM) infusion; 60 min post REM infusion
| Intervention | percentage of change (Number) | |
|---|---|---|
| 15 min post remifentanil infusion | 60 min post remifentanil infusion | |
| Placebo | -34 | 141.5 |
| Propranolol | -28 | -19 |
Opioid Consumption
Number of morphine equivalents used by subject during first 24 hours after discharge from Post-Anesthesia Care Unit (NCT01430182)
Timeframe: First 24 hours after discharge from Post-Anesthesia Care Unit
| Intervention | mg of morphine IV equivalents (Mean) |
|---|---|
| Methadone 0.2 mg/kg | 50.9 |
| Morphine 0.2 mg/kg | 37.5 |
Reviews
77 reviews available for methadone and Ache
| Article | Year |
|---|---|
Problematic Opioid Use Among Older Adults: Epidemiology, Adverse Outcomes and Treatment Considerations.
Topics: Aged; Analgesics, Opioid; Buprenorphine; Humans; Methadone; Opioid-Related Disorders; Pain | 2021 |
Methadone Switching for Cancer Pain: A New Classification of Initiation Protocols, Based on a Critical Literature Review.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Morphine; Neoplasms; Pain; Randomized Controlled | 2021 |
Opioid-induced Neurotoxicity in Patients with Cancer Pain.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Neoplasms; Pain; Palliative Care | 2023 |
Anesthesia update - Incorporating methadone into companion animal anesthesia and analgesic protocols: A narrative review.
Topics: Analgesics, Opioid; Anesthesia; Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Methadone; Pain; Pe | 2023 |
Why equianalgesic tables are only part of the answer to equianalgesia.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Dosage Calculations; Humans; Methadone; M | 2020 |
Methadone: Maximizing Safety and Efficacy for Pain Control in Patients with Cancer.
Topics: Half-Life; Humans; Inappropriate Prescribing; Methadone; Neoplasms; Pain | 2018 |
From Tramadol to Methadone: Opioids in the Treatment of Pain and Dyspnea in Pediatric Palliative Care.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Dyspnea; Humans; Infant; Infant, Newborn; M | 2019 |
Metabolic and toxicological considerations of the opioid replacement therapy and analgesic drugs: methadone and buprenorphine.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Drug Interactions; Humans; Methadone; Opiate Substitutio | 2013 |
Transdermal fentanyl for cancer pain.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Methadone; Morphine; Neoplasms; Pai | 2013 |
Behavioral effects of perinatal opioid exposure.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Female; Humans; Illicit Drugs; Infant, Ne | 2014 |
Therapeutic challenges in cancer pain management: a systematic review of methadone.
Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain; Pain Management | 2014 |
Methods of Rotation From Another Strong Opioid to Methadone for the Management of Cancer Pain: A Systematic Review of the Available Evidence.
Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain; Pain Management | 2015 |
The US Congressional "Decade on Pain Control and Research" 2001-2011: A Review.
Topics: Analgesics, Opioid; Biomedical Research; Drug and Narcotic Control; Humans; Methadone; Opioid-Relate | 2015 |
Methadone analgesia in the critically ill.
Topics: Adult; Analgesics, Opioid; Child; Critical Illness; Delirium; Humans; Intensive Care Units; Methadon | 2016 |
The use of methadone to facilitate opioid weaning in pediatric critical care patients: a systematic review of the literature and meta-analysis.
Topics: Analgesics, Opioid; Child; Critical Care; Humans; Methadone; Pain; Substance Withdrawal Syndrome | 2017 |
Methadone for cancer pain.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Humans; Methadone; Middle Aged; Morphine; Neopla | 2017 |
Equianalgesia: applying evidence-based practice guidelines.
Topics: Analgesia; Analgesics, Opioid; Codeine; Drug Monitoring; Evidence-Based Medicine; Humans; Hydromorph | 2008 |
Pediatric palliative care: use of opioids for the management of pain.
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Buprenorphine; Child; Delayed-A | 2009 |
Methadone-induced mortality in the treatment of chronic pain: role of QT prolongation.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Chronic Disease; Delayed Rectifier Potassium Channels; ERG | 2009 |
Opioids in people with cancer-related pain.
Topics: Administration, Oral; Analgesics; Analgesics, Opioid; Codeine; Fentanyl; Humans; Methadone; Neoplasm | 2008 |
Clinical approaches to special issues related to opioid therapy.
Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Nurse's Role; Nursing Assessment; Nursing Methodol | 2009 |
[Methadone treatment and its dangers].
Topics: Adult; Analgesics, Opioid; Child, Preschool; Drug Interactions; Drug Overdose; Electrocardiography; | 2009 |
The role of methadone in cancer pain treatment--a review.
Topics: Analgesics, Opioid; Drug Administration Routes; Drug Administration Schedule; Drug Interactions; Hum | 2009 |
Methadone deaths: risk factors in pain and addicted populations.
Topics: Analgesics, Opioid; Chronic Disease; Death, Sudden, Cardiac; Drug Overdose; Humans; Methadone; Opiat | 2010 |
[Treatment of acute pain during drug-assisted rehabilitation].
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents | 2010 |
Morphine to methadone conversion: an interpretation of published data.
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Pain; Palliative Care; Receptors, N-Methyl-D-Aspart | 2011 |
Review of cancer pain management in patients receiving maintenance methadone therapy.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Huma | 2011 |
Methadone: marvelous, malevolent, or merely misunderstood?
Topics: Analgesics, Opioid; Humans; Methadone; Pain; Pain Management | 2011 |
Prescription pain medication dependence.
Topics: Analgesics; Buprenorphine; Humans; Methadone; Naltrexone; Narcotic Antagonists; Opiate Substitution | 2011 |
A review of forensic implications of opioid prescribing with examples from malpractice cases involving opioid-related overdose.
Topics: Analgesics, Opioid; Chronic Disease; Drug Overdose; Drug Prescriptions; Forensic Medicine; Humans; K | 2011 |
Is oral methadone better than placebo or other oral/transdermal opioids in the management of pain?
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Humans; Methadone; Neoplasms; P | 2011 |
Acute pain management in opioid-tolerant patients: a growing challenge.
Topics: Acute Disease; Analgesics; Analgesics, Opioid; Animals; Australia; Buprenorphine; Buprenorphine, Nal | 2011 |
The effect of age on opioid switching to methadone: a systematic review.
Topics: Age Factors; Analgesics, Opioid; Drug Substitution; Humans; Methadone; Pain | 2012 |
Management of opioid substitution therapy during medical intervention.
Topics: Analgesics; Australia; Buprenorphine; Comorbidity; Drug Interactions; Female; Humans; Liver Diseases | 2012 |
The use of methadone for cancer pain.
Topics: Analgesics, Opioid; Attitude of Health Personnel; Biological Availability; Child; Clinical Protocols | 2002 |
Management of the hospitalized injection drug user.
Topics: Chronic Disease; Comorbidity; Female; Hospitalization; Humans; Male; Methadone; Pain; Severity of Il | 2002 |
Intrathecal therapy for chronic pain.
Topics: Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Hum | 2001 |
Clinical use of methadone.
Topics: Analgesics, Opioid; Biological Availability; Dosage Forms; Drug Administration Schedule; Drug Intera | 2002 |
Morphine is not the only analgesic in palliative care: literature review.
Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Ketamine; Methadone; Morphine; Neoplasms; Pain; Pa | 2004 |
Methadone for cancer pain.
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Neoplasms; Pain; Pain Measurement; Randomized Contr | 2004 |
Methadone: applied pharmacology and use as adjunctive treatment in chronic pain.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Opioid-Related Disorders; Pain | 2004 |
Cancer pain management in children.
Topics: Analgesics, Opioid; Anesthesia, Conduction; Child; Chronic Disease; Fentanyl; Humans; Injections, Sp | 2004 |
Pain and terminal delirium research in the elderly.
Topics: Aged; Algorithms; Analgesics, Opioid; Anti-Infective Agents; Constipation; Delirium; Drug Interactio | 2005 |
Methadone treatment for pain states.
Topics: Analgesics, Opioid; Chronic Disease; Drug Costs; Drug Interactions; Humans; Methadone; Pain; Therape | 2005 |
A review of the use of methadone for the treatment of chronic noncancer pain.
Topics: Analgesics, Opioid; Canada; Chronic Disease; Humans; Legislation, Drug; Methadone; Pain | 2005 |
Acute pain management for patients receiving maintenance methadone or buprenorphine therapy.
Topics: Acute Disease; Adult; Analgesics, Opioid; Buprenorphine; Female; Heroin Dependence; Humans; Methadon | 2006 |
Pharmacokinetics of methadone.
Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme | 2005 |
Pharmacokinetics of methadone.
Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme | 2005 |
Pharmacokinetics of methadone.
Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme | 2005 |
Pharmacokinetics of methadone.
Topics: Aged; Analgesics, Opioid; Area Under Curve; Biological Availability; Child; Cytochrome P-450 Enzyme | 2005 |
Difficult cases in pain management: use of methadone in a multifactorial approach.
Topics: Administration, Oral; Aged; Analgesics, Opioid; Communication; Drug Monitoring; Female; Humans; Inte | 2006 |
Difficult pain.
Topics: Acupuncture; Analgesia; Analgesics, Opioid; Forecasting; Humans; Methadone; Nervous System Diseases; | 2006 |
Methadone for treatment of cancer pain.
Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain | 2006 |
Pharmacological approaches to the management of pain in the neonatal intensive care unit.
Topics: Analgesics; Analgesics, Opioid; Female; Humans; Infant, Newborn; Infant, Premature; Intensive Care U | 2007 |
Practical guide to opioids and their complications in managing cancer pain. What oncologists need to know.
Topics: Analgesics, Opioid; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Routes; D | 2007 |
The management of pain in children with life-limiting illnesses.
Topics: Analgesics, Opioid; Child; Chronic Disease; Codeine; Fentanyl; Humans; Hydromorphone; Ketamine; Meth | 2007 |
Methadone for cancer pain.
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Neoplasms; Pain; Pain Measurement; Randomized Contr | 2007 |
Palliative care pharmacotherapy literature summaries and analyses.
Topics: Analgesics, Opioid; Cardiovascular Diseases; Clinical Trials as Topic; Cyclooxygenase 2 Inhibitors; | 2007 |
Treatment of opioid-dependent pregnant women: clinical and research issues.
Topics: Analgesics, Opioid; Buprenorphine; Clinical Trials as Topic; Decision Making; Female; Humans; Infant | 2008 |
Clinical pharmacology of methadone for pain.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Chronic Disease; Clinical Trials as Topic; Drug Interactio | 2008 |
Interindividual variability of methadone response: impact of genetic polymorphism.
Topics: ATP-Binding Cassette Transporters; Cytochrome P-450 Enzyme System; Drug Interactions; Genetic Hetero | 2008 |
Effectiveness of opioids in the treatment of chronic non-cancer pain.
Topics: Analgesics, Opioid; Drug Administration Schedule; Fentanyl; Humans; Methadone; Morphine; Oxycodone; | 2008 |
Consensus guideline on parenteral methadone use in pain and palliative care.
Topics: Hospice Care; Humans; Methadone; Pain; Palliative Care; Practice Guidelines as Topic | 2008 |
Recent advances in acute pain management.
Topics: Acute Disease; Administration, Oral; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; | 1995 |
Should people taking opioids for medical reasons be allowed to work and drive?
Topics: Accidents, Occupational; Accidents, Traffic; Analgesics, Opioid; Heroin Dependence; Humans; Long-Ter | 1996 |
[Treatment of pain in oncology].
Topics: Administration, Cutaneous; Analgesics, Opioid; Anesthetics, Dissociative; Diphosphonates; Fentanyl; | 1997 |
Opioid rotation for cancer pain: rationale and clinical aspects.
Topics: Analgesics, Opioid; Fentanyl; Humans; Hydromorphone; Methadone; Morphine; Narcotics; Neoplasms; Pain | 1999 |
Opioid switch to oral methadone in cancer pain.
Topics: Administration, Oral; Analgesics, Opioid; Combined Modality Therapy; Cross-Sectional Studies; Dose-R | 2000 |
Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration.
Topics: Analgesics, Opioid; Drug Administration Routes; Drug Interactions; Humans; Methadone; Neoplasms; Pai | 2001 |
[Treatment of pain in cancer with systemically administered opioids].
Topics: Analgesics, Opioid; Delayed-Action Preparations; Drug Administration Schedule; Humans; Infusion Pump | 2001 |
Strategies for the treatment of cancer pain in the new millennium.
Topics: Analgesics, Opioid; Cannabinoids; Dose-Response Relationship, Drug; Drug Therapy, Combination; Human | 2001 |
Methadone: the renaissance.
Topics: Analgesics, Opioid; Animals; Consumer Product Safety; Dose-Response Relationship, Drug; Humans; Meth | 2001 |
Methadone use in cancer patients with pain: a review.
Topics: Analgesics, Opioid; Drug Interactions; Humans; Methadone; Neoplasms; Pain | 2002 |
[Delayed-action opioids--limitations and advantages].
Topics: Buprenorphine; Delayed-Action Preparations; Humans; Methadone; Morphine; Pain; Palliative Care | 1990 |
Neuropeptide effects on brain development.
Topics: 5,7-Dihydroxytryptamine; Adrenocorticotropic Hormone; Animals; Animals, Newborn; Behavior, Animal; B | 1985 |
The pharmacologic management of pain in children.
Topics: Analgesia, Epidural; Analgesics; Child; Child, Preschool; Codeine; Fentanyl; Humans; Infant; Meperid | 1989 |
Future trends in regional spinal opioids.
Topics: Analgesics, Opioid; Anesthesia, Epidural; Animals; Humans; Injections, Spinal; Kinetics; Lipids; Met | 1986 |
The opioid-dependent patient with acute pain.
Topics: Acute Disease; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pain; Pain, Postoperative; Su | 1987 |
Drug therapy: analgetic drugs--the potent analgetics.
Topics: Analgesics; Blood Circulation; Fentanyl; Humans; Intestines; Levallorphan; Meperidine; Methadone; Me | 1972 |
Editorial: Analgesia in myocardial infarction.
Topics: Analgesia; Analgesics; Animals; Blood Pressure; Cyclizine; Heart Arrest; Heroin; Humans; Injections, | 1974 |
Trials
55 trials available for methadone and Ache
| Article | Year |
|---|---|
Hyperbaric Oxygen Therapy for Pain, Opioid Withdrawal, and Related Symptoms: A Pilot Randomized Controlled Trial.
Topics: Adult; Analgesics, Opioid; Humans; Hyperbaric Oxygenation; Methadone; Opioid-Related Disorders; Oxyg | 2022 |
Conversion ratios for opioid switching: a pragmatic study.
Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain; Palliative Care | 2022 |
Delta-9-tetrahydrocannabinol modulates pain sensitivity among persons receiving opioid agonist therapy for opioid use disorder: A within-subject, randomized, placebo-controlled laboratory study.
Topics: Analgesics, Opioid; Dronabinol; Female; Humans; Male; Methadone; Opioid-Related Disorders; Pain | 2023 |
A single-institution, randomized, pilot study evaluating the efficacy of gabapentin and methadone for patients undergoing chemoradiation for head and neck squamous cell cancer.
Topics: Adult; Aged; Analgesics; Chemoradiotherapy; Dose-Response Relationship, Drug; Female; Gabapentin; Hu | 2020 |
Pain in methadone patients: Time to address undertreatment and suicide risk (ANRS-Methaville trial).
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Female; Humans; Inappropriate Prescribing; Male; Methad | 2017 |
Can Saliva and Plasma Methadone Concentrations Be Used for Enantioselective Pharmacokinetic and Pharmacodynamic Studies in Patients With Advanced Cancer?
Topics: Aged; Analgesics, Opioid; Chromatography, High Pressure Liquid; Female; Humans; Male; Methadone; Mid | 2017 |
Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses.
Topics: Animals; Conscious Sedation; Drug Therapy, Combination; Female; Horses; Hypnotics and Sedatives; Imi | 2019 |
Comparison of perioperative analgesic efficacy between methadone and butorphanol in cats.
Topics: Analgesics, Opioid; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Butorphanol; Cat Disea | 2013 |
Antinociceptive effects of methadone combined with detomidine or acepromazine in horses.
Topics: Acepromazine; Animals; Drug Therapy, Combination; Electric Stimulation; Horse Diseases; Horses; Hot | 2016 |
Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.
Topics: Adolescent; Analgesics, Opioid; Anemia, Sickle Cell; Child; Female; Humans; Male; Methadone; Pain | 2016 |
[Effects of morphine, butorphanol and levomethadone in different doses on thermal nociceptive thresholds in horses].
Topics: Analgesics; Animals; Butorphanol; Horse Diseases; Horses; Hot Temperature; Methadone; Morphine; Pain | 2017 |
Experience of methadone therapy in 100 consecutive chronic pain patients in a multidisciplinary pain center.
Topics: Ambulatory Care; Analgesics, Opioid; Canada; Chronic Disease; Female; Humans; Male; Methadone; Middl | 2008 |
The role of methadone in opioid rotation-a Polish experience.
Topics: Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Tolerance; Female; Humans; M | 2009 |
Early switching from morphine to methadone is not improved by acetaminophen in the analgesia of oncologic patients: a prospective, randomized, double-blind, placebo-controlled study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opi | 2010 |
The effect of oral methadone on the QTc interval in advanced cancer patients: a prospective pilot study.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relationship, Drug; Electrocardiog | 2010 |
The use of fentanyl buccal tablets as breakthrough medication in patients receiving chronic methadone therapy: an open label preliminary study.
Topics: Administration, Buccal; Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Tole | 2011 |
Plasma concentrations and behavioral, antinociceptive, and physiologic effects of methadone after intravenous and oral transmucosal administration in cats.
Topics: Administration, Buccal; Analgesia; Analgesics, Opioid; Animals; Behavior, Animal; Catheterization, C | 2011 |
How to switch from morphine or oxycodone to methadone in cancer patients? a randomised clinical phase II trial.
Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relationship, Drug; | 2011 |
Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; | 2012 |
Epidemiology of pain among outpatients in methadone maintenance treatment programs.
Topics: Adult; Comorbidity; Female; Humans; Male; Methadone; Middle Aged; Opiate Substitution Treatment; Opi | 2013 |
Epidural methadone results in dose-dependent analgesia in cancer pain, further enhanced by epidural dexamethasone.
Topics: Adult; Aged; Analgesia, Epidural; Dexamethasone; Drug Administration Routes; Female; Humans; Lidocai | 2013 |
Transcutaneous iontophoresis of methadone provokes local flushing and thermal hyperalgesia.
Topics: Administration, Cutaneous; Adolescent; Adult; Female; Flushing; Hot Temperature; Humans; Hyperalgesi | 2003 |
Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Delayed-Action Preparation | 2004 |
Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Delayed-Action Preparation | 2004 |
Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Delayed-Action Preparation | 2004 |
Methadone versus morphine as a first-line strong opioid for cancer pain: a randomized, double-blind study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Delayed-Action Preparation | 2004 |
Characterization of the early pharmacodynamic profile of oral methadone for cancer-related breakthrough pain: a pilot study.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Chronic Disease; Cross-Over Studies; Female; | 2004 |
Significantly higher methadone dose for methadone maintenance treatment (MMT) patients with chronic pain.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Benzodiazepines; Case-Control Studies; Chronic Dise | 2005 |
Measurement of QTc in patients receiving chronic methadone therapy.
Topics: Electrocardiography; Female; Heart Rate; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Pa | 2005 |
Rapid switching between transdermal fentanyl and methadone in cancer patients.
Topics: Administration, Cutaneous; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Methadone; Middle Age | 2005 |
Intermittent subcutaneous methadone administration in the management of cancer pain.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Injec | 2005 |
Opioid rotation to methadone at home.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Home Care Services; Humans; Male; Methad | 2006 |
Brief report: Training internists in shared decision making about chronic opioid treatment for noncancer pain.
Topics: Analgesics, Opioid; Attitude of Health Personnel; Chronic Disease; Decision Making; Humans; Internal | 2006 |
Analgesic effects of subarachnoidally administered hyperbaric opioids in horses.
Topics: Analgesia; Analgesics, Opioid; Animals; Buprenorphine; Cross-Over Studies; Female; Horse Diseases; H | 2006 |
Methadone in the treatment of pain and terminal delirum in advanced cancer patients.
Topics: Aged; Analgesics, Opioid; Delirium; Dose-Response Relationship, Drug; Drug Administration Schedule; | 2005 |
The effect of opioids on sleep architecture.
Topics: Adolescent; Adult; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Admini | 2007 |
The effect of opioids on sleep architecture.
Topics: Adolescent; Adult; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Admini | 2007 |
The effect of opioids on sleep architecture.
Topics: Adolescent; Adult; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Admini | 2007 |
The effect of opioids on sleep architecture.
Topics: Adolescent; Adult; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Drug Admini | 2007 |
Antinociceptive effects of high-dose remifentanil in male methadone-maintained patients.
Topics: Adult; Analgesics, Opioid; Cold Temperature; Drug Interactions; Drug Tolerance; Humans; Infusions, I | 2008 |
Custom-made capsules and suppositories of methadone for patients on high-dose opioids for cancer pain.
Topics: Aged; Analgesics, Opioid; Capsules; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Female; | 1995 |
Stereoselective pharmacokinetics of methadone in chronic pain patients.
Topics: Aged; Analgesics, Opioid; Biological Availability; Chromatography, High Pressure Liquid; Chronic Dis | 1996 |
Patient-controlled analgesia with oral methadone in cancer pain: preliminary report.
Topics: Administration, Oral; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Dose-Response Relatio | 1996 |
Pain perception of intravenous heroin users on maintenance therapy with levomethadone.
Topics: Adult; Female; Heroin Dependence; Humans; Male; Methadone; Narcotics; Pain; Pain Measurement; Single | 1996 |
Opioid-sparing effect of diclofenac in cancer pain.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Di | 1997 |
Methadone titration in opioid-resistant cancer pain.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Drug Administration Schedu | 1999 |
Differences in the ratios of morphine to methadone in patients with neuropathic pain versus non-neuropathic pain.
Topics: Adult; Aged; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methadone; Midd | 1999 |
Pain responses in methadone-maintained opioid abusers.
Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon | 2000 |
Pain responses in methadone-maintained opioid abusers.
Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon | 2000 |
Pain responses in methadone-maintained opioid abusers.
Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon | 2000 |
Pain responses in methadone-maintained opioid abusers.
Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon | 2000 |
Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study.
Topics: Administration, Oral; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methad | 2001 |
Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study.
Topics: Administration, Oral; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methad | 2001 |
Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study.
Topics: Administration, Oral; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methad | 2001 |
Switching from morphine to methadone to improve analgesia and tolerability in cancer patients: a prospective study.
Topics: Administration, Oral; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methad | 2001 |
Pitfalls of opioid rotation: substituting another opioid for methadone in patients with cancer pain.
Topics: Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Hydromorphone; Levorphanol; Male; Methado | 2002 |
Analgesic, central, cardiovascular and endocrine effects of the enkephalin analogue Tyr-D.Arg-Gly-Phe(4NO2)-Pro-NH2 (443C81) in healthy volunteers.
Topics: Adult; Amino Acid Sequence; Analgesics; Analgesics, Opioid; Blood Pressure; Central Nervous System; | 1990 |
Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain.
Topics: Adult; Aged; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; Infusions, | 1990 |
Effects of an opiate on cold-induced pain and the CNS in healthy volunteers.
Topics: Adult; Analgesics, Opioid; Blood Pressure; Central Nervous System; Cold Temperature; Dose-Response R | 1985 |
The effects of naloxone on opiate and placebo analgesia in healthy volunteers.
Topics: Adult; Analgesia; Analgesics, Opioid; Codeine; Endorphins; Female; Humans; Male; Methadone; Middle A | 1985 |
Dipipanone and nifedipine in cold induced pain; analgesia not due to skin warming.
Topics: Adult; Analgesics, Opioid; Blood Pressure; Cold Temperature; Double-Blind Method; Female; Heart Rate | 1987 |
A comparative study of the efficacy and pharmacokinetics of oral methadone and morphine in the treatment of severe pain in patients with cancer.
Topics: Administration, Oral; Aged; Biological Availability; Clinical Trials as Topic; Dose-Response Relatio | 1986 |
A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control.
Topics: Abdomen; Adult; Blood Specimen Collection; Double-Blind Method; Drug Evaluation; Female; Humans; Mal | 1986 |
A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control.
Topics: Abdomen; Adult; Blood Specimen Collection; Double-Blind Method; Drug Evaluation; Female; Humans; Mal | 1986 |
A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control.
Topics: Abdomen; Adult; Blood Specimen Collection; Double-Blind Method; Drug Evaluation; Female; Humans; Mal | 1986 |
A double-blind comparison of the efficacy of methadone and morphine in postoperative pain control.
Topics: Abdomen; Adult; Blood Specimen Collection; Double-Blind Method; Drug Evaluation; Female; Humans; Mal | 1986 |
Effects of diamorphine, methadone, morphine, and pentazocine in patients with suspected acute myocardial infarction.
Topics: Acute Disease; Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Heart Rate; Heroin; Hu | 1969 |
The clinical testing of weak oral analgesics.
Topics: Administration, Oral; Analgesics; Clinical Trials as Topic; Drug Evaluation; Humans; Meperidine; Met | 1974 |
The quantitative measurement of joint changes in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Circadian Rhythm; Clinical Trials as Topic; Finger Joint; Fingers; Humans; Ma | 1968 |
Post-operative pain relief: comparison of methadone and morphine when used concurrently with nitrous-oxide analgesia.
Topics: Humans; Methadone; Morphine; Nitrous Oxide; Pain; Postoperative Care | 1966 |
Other Studies
348 other studies available for methadone and Ache
| Article | Year |
|---|---|
The xanthene-9-spiro-4'-piperidine nucleus as a probe for opiate activity.
Topics: Analgesics, Opioid; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Mice; Molecular Structure; Mus | 1989 |
A history of opioid abuse: Why buprenorphine is superior for the management of opioid use disorder and pain.
Topics: Analgesics, Opioid; Buprenorphine; Humans; Methadone; Naltrexone; Opiate Substitution Treatment; Opi | 2021 |
The effect of a methadone reformulation on opioid agonist treatment outcomes: A population-based study in British Columbia, Canada, 2013-14.
Topics: Analgesics, Opioid; British Columbia; Humans; Methadone; Opiate Substitution Treatment; Opioid-Relat | 2022 |
Association of polymorphisms in
Topics: Analgesics, Opioid; beta-Arrestin 2; Cancer Pain; Humans; Methadone; Neoplasms; Pain; Polymorphism, | 2022 |
Intraoperative Methadone Use in Pediatric Burn Patients.
Topics: Adult; Analgesics, Opioid; Burns; Child; Humans; Methadone; Morphine; Pain; Retrospective Studies | 2022 |
Factors associated with retention on medications for opioid use disorder among a cohort of adults seeking treatment in the community.
Topics: Adult; Analgesics, Opioid; Buprenorphine; Drug Overdose; Female; Humans; Male; Methadone; Naltrexone | 2022 |
Methadone as First-line Opioid for the Management of Cancer Pain.
Topics: Analgesics, Opioid; Cancer Pain; Humans; Methadone; Neoplasms; Pain; Prospective Studies | 2022 |
Tracheostomy decreases continuous analgesia and sedation requirements.
Topics: Adult; Aged; Analgesia; Analgesics; Anti-Anxiety Agents; Endrin; Female; Fentanyl; Humans; Hypnotics | 2022 |
Lucid Dreams Associated with Pregabalin: Implications for Clinical Practice.
Topics: Dreams; Female; Humans; Methadone; Pain; Pregabalin | 2022 |
Characteristics of Prescription Opioid Analgesics in Pregnancy and Risk of Neonatal Opioid Withdrawal Syndrome in Newborns.
Topics: Adult; Analgesics, Opioid; Codeine; Cohort Studies; Female; Humans; Hydrocodone; Hydromorphone; Infa | 2022 |
Understanding motivations and use typologies of gabapentin with opioid agonist medications.
Topics: Analgesics, Opioid; Buprenorphine; Cross-Sectional Studies; Gabapentin; Humans; Methadone; Motivatio | 2023 |
Understanding motivations and use typologies of gabapentin with opioid agonist medications.
Topics: Analgesics, Opioid; Buprenorphine; Cross-Sectional Studies; Gabapentin; Humans; Methadone; Motivatio | 2023 |
Understanding motivations and use typologies of gabapentin with opioid agonist medications.
Topics: Analgesics, Opioid; Buprenorphine; Cross-Sectional Studies; Gabapentin; Humans; Methadone; Motivatio | 2023 |
Understanding motivations and use typologies of gabapentin with opioid agonist medications.
Topics: Analgesics, Opioid; Buprenorphine; Cross-Sectional Studies; Gabapentin; Humans; Methadone; Motivatio | 2023 |
Safety and preliminary outcomes of short-acting opioid agonist treatment (sOAT) for hospitalized patients with opioid use disorder.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Female; Humans; Hydromo | 2023 |
Comparing National Methadone Equianalgesic Tools.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Methadone; Pain; Palliative Care | 2023 |
Feasibility of methadone for pain relief in first trimester abortion.
Topics: Abortion, Induced; Feasibility Studies; Female; Humans; Methadone; Pain; Pain Management; Pregnancy; | 2023 |
Feasibility of methadone for pain relief in first trimester abortion (Boston, Massachusetts 2022).
Topics: Abortion, Induced; Boston; Feasibility Studies; Female; Humans; Massachusetts; Methadone; Pain; Preg | 2023 |
Drug use patterns and factors related to the use and discontinuation of medications for opioid use disorder in the age of fentanyl: findings from a mixed-methods study of people who use drugs.
Topics: Analgesics, Opioid; Benzodiazepines; Buprenorphine; Crack Cocaine; Drug Overdose; Fentanyl; Heroin; | 2023 |
Switching to Intravenous Methadone in Advanced Cancer Patients: A Retrospective Analysis.
Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain; Retrospective Studies | 2023 |
Rescue Analgesia for Opioid-Dependent Individuals on Opioid Agonist Treatment during Hospitalization: Adherence to Guideline Treatment.
Topics: Adult; Analgesics; Analgesics, Opioid; Female; Hospitalization; Humans; Male; Methadone; Middle Aged | 2023 |
Perioperative Methadone: Perilous or Pain Panacea?
Topics: Analgesics, Opioid; Humans; Methadone; Pain; Pain, Postoperative | 2023 |
Assessing the impact of the slow-release oral morphine drug shortages in Ontario, Canada: A population-based time series analysis.
Topics: Administration, Oral; Analgesics, Opioid; Delayed-Action Preparations; Female; Humans; Male; Methado | 2023 |
Retrospective analysis reveals significant association of hypoglycemia with tramadol and methadone in contrast to other opioids.
Topics: Adult; Aged; Analgesics, Opioid; Databases, Factual; Female; Humans; Hypoglycemia; Male; Methadone; | 2019 |
Comparing Methadone Rotation to Consensus Opinion.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Drug Substitution; Female; Humans; Male; Methado | 2020 |
Pain outcomes among patients after cesarean consuming buprenorphine or methadone and opioid-naïve patients.
Topics: Analgesics, Opioid; Buprenorphine; Female; Humans; Methadone; Opioid-Related Disorders; Pain; Pregna | 2020 |
Alexithymia and pain experience among patients using methadone-maintenance therapy.
Topics: Adult; Affective Symptoms; Catastrophization; Emotions; Humans; Male; Methadone; Middle Aged; Opiate | 2021 |
Plasma levels of a methadone constant rate infusion and their corresponding effects on thermal and mechanical nociceptive thresholds in dogs.
Topics: Administration, Intravenous; Analgesics, Opioid; Animals; Bradycardia; Cross-Over Studies; Dogs; Fem | 2021 |
A Virtual Reality Meditative Intervention Modulates Pain and the Pain Neuromatrix in Patients with Opioid Use Disorder.
Topics: Female; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related Disorders; Pain; Prospectiv | 2021 |
Pronounced Regional Disparities in United States Methadone Distribution.
Topics: Analgesics, Opioid; Buprenorphine; Humans; Methadone; Opiate Substitution Treatment; Opioid-Related | 2022 |
Methadone for Palliative Care Providers: A Case-Based Flipped Classroom Module for Faculty and Fellows.
Topics: Faculty; Humans; Methadone; Pain; Pain Management; Palliative Care; United States | 2021 |
Methadone Prescribing and Overdose and the Association with Medicaid Preferred Drug List Policies - United States, 2007-2014.
Topics: Databases, Factual; Drug Overdose; Drug Prescriptions; Health Policy; Humans; Medicaid; Methadone; P | 2017 |
Methadone-Induced Neurotoxicity in Advanced Cancer: A Case Report.
Topics: Analgesics, Opioid; Humans; Male; Methadone; Middle Aged; Neoplasms; Neurotoxicity Syndromes; Pain; | 2017 |
Methadone Dose Selection for Treatment of Pain Compared with Consensus Recommendations.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans | 2017 |
Prevalence of pain and its socio-demographic and clinical correlates among heroin-dependent patients receiving methadone maintenance treatment.
Topics: Adult; Cross-Sectional Studies; Female; Heroin; Heroin Dependence; Humans; Male; Methadone; Middle A | 2017 |
Opioid tapering in patients with prescription opioid use disorder: A retrospective study.
Topics: Analgesics, Opioid; Chronic Pain; Drug Prescriptions; Female; Humans; Male; Methadone; Middle Aged; | 2017 |
[ACUTE PAIN MANAGEMENT IN PATIENT ON OPIOID SUBSTITUTION THERAPY WITH\
METHADONE OR BUPRENORPHINE].
Topics: Acute Disease; Buprenorphine; Humans; Methadone; Opiate Substitution Treatment; Pain; Pain Managemen | 2016 |
Delta/mu opioid receptor interactions in operant conditioning assays of pain-depressed responding and drug-induced rate suppression: assessment of therapeutic index in male Sprague Dawley rats.
Topics: Analgesics, Opioid; Animals; Benzamides; Conditioning, Operant; Dose-Response Relationship, Drug; Ma | 2018 |
Opioid Utilization by Pregnant Women with Sickle Cell Disease and the Risk of Neonatal Abstinence Syndrome.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Case-Control Studies; Female; Humans; Incidence; Met | 2018 |
Neurobiology of Opioid Use Disorder and Comorbid Traumatic Brain Injury.
Topics: Analgesics, Opioid; Brain Injuries, Traumatic; Buprenorphine; Humans; Methadone; Naltrexone; Opioid- | 2018 |
Pain as a risk factor for substance use: a qualitative study of people who use drugs in British Columbia, Canada.
Topics: Adult; Aged; Analgesics, Opioid; British Columbia; Female; Focus Groups; Harm Reduction; Health Serv | 2018 |
Prevalence and Correlates of Loss of Control Eating among Adults Presenting for Methadone Maintenance Treatment.
Topics: Adult; Comorbidity; Eating; Feeding and Eating Disorders; Female; Humans; Male; Methadone; Middle Ag | 2018 |
Safe and Appropriate Use of Methadone in Hospice and Palliative Care: Expert Consensus White Paper.
Topics: Analgesics, Opioid; Hospice Care; Humans; Methadone; Pain; Palliative Care | 2019 |
Efficacy of low-dose and/or adjuvant methadone in palliative medicine.
Topics: Humans; Methadone; Pain; Palliative Medicine; Randomized Controlled Trials as Topic; Retrospective S | 2022 |
[A Case of Methadone Induced Drowsiness Following Trabectedin Induced Liver Injury].
Topics: Aged; Chemical and Drug Induced Liver Injury; Histiocytoma, Malignant Fibrous; Humans; Liver; Male; | 2019 |
The poor use of methadone in Italian hospices.
Topics: Analgesics, Opioid; Attitude of Health Personnel; Data Collection; Home Care Services; Hospice Care; | 2013 |
Very-high-dose methadone with minimal toxicity and inadequate pain control in a hospice patient with cancer.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Hospice Care; Humans; Laryngeal Neoplasms; Mal | 2013 |
How can a methadone and an opiate-positive immunoassay result be reconciled in a patient prescribed only OxyContin and Wellbutrin?
Topics: Adult; Bupropion; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay; Male; Methadone; Molecu | 2013 |
Correlates of depressive symptoms among alcohol-using methadone maintained adults.
Topics: Adult; Alcohol Drinking; Alcohol-Related Disorders; Analgesics, Opioid; Cross-Sectional Studies; Dep | 2012 |
Enhanced antinociceptive efficacy of epidural compared with i.v. methadone in a rat model of thermal nociception.
Topics: Analgesics, Opioid; Animals; Epidural Space; Injections, Intravenous; Male; Methadone; Models, Anima | 2014 |
Pain management discussion forum.
Topics: Analgesics, Opioid; Hemophilia B; Humans; Male; Methadone; Opiate Substitution Treatment; Opioid-Rel | 2013 |
Changes of QTc interval after opioid switching to oral methadone.
Topics: Aged; Analgesics, Opioid; Electrocardiography; Female; Humans; Linear Models; Long QT Syndrome; Male | 2013 |
Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state.
Topics: Animals; Fentanyl; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Methadone; Mice; Narcotics; | 2014 |
Topical methadone: an alternative for pain control in end-of-life management.
Topics: Administration, Topical; Analgesics, Opioid; Drug Compounding; Humans; Methadone; Pain; Pain Managem | 2014 |
Methadone for pain and the risk of adverse cardiac outcomes.
Topics: Age Factors; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Heart Diseases; Humans; M | 2014 |
What is your gut feeling about opioid rotation?
Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Biological Availability; Delaye | 2015 |
Methadone overdose and withdrawal in a tetraplegic patient: a case report.
Topics: Adult; Analgesics, Opioid; Drug Overdose; Female; Humans; Methadone; Pain; Quadriplegia; Spinal Cord | 2014 |
Informed consent abandoned--patient given contraindicated drug.
Topics: Alcoholism; Contraindications; Depressive Disorder; Humans; Informed Consent; Male; Medication Recon | 2014 |
My trauma patient takes methadone: how do I manage his pain?
Topics: Accidents, Traffic; Analgesics, Opioid; Emergency Service, Hospital; Humans; Male; Methadone; Pain; | 2014 |
Methadone in combination with medetomidine as premedication prior to ovariohysterectomy and castration in the cat.
Topics: Analgesia; Analgesics, Opioid; Anesthesia, General; Animals; Cat Diseases; Cats; Drug Therapy, Combi | 2015 |
The use of very-low-dose methadone and haloperidol for pain control in the hospital setting: a preliminary report.
Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesics, Opioid; California; Dose-Response Relatio | 2015 |
HIV-gp120 and physical dependence to buprenorphine.
Topics: Animals; Buprenorphine; HIV Envelope Protein gp120; HIV Infections; Male; Methadone; Opioid-Related | 2015 |
Methadone for Pain: What to Do When the Oral Route Is Not Available.
Topics: Administration, Rectal; Analgesics, Opioid; Fatal Outcome; Female; Humans; Methadone; Middle Aged; P | 2015 |
Exposure to prescription opioid analgesics in utero and risk of neonatal abstinence syndrome: population based cohort study.
Topics: Adolescent; Adult; Analgesics, Opioid; Cohort Studies; Dose-Response Relationship, Drug; Female; Hum | 2015 |
Mediation of opioid analgesia by a truncated 6-transmembrane GPCR.
Topics: Alternative Splicing; Analgesics, Opioid; Animals; Exons; Gene Targeting; Methadone; Mice; Mice, Kno | 2015 |
Use of Very-Low-Dose Methadone and Haloperidol for Pain Control in Palliative Care Patients: Are the Sigma-1 Receptors Involved?
Topics: Analgesics, Opioid; Female; Haloperidol; Humans; Male; Methadone; Morphine; Pain; Pain Management; P | 2015 |
Underestimated and unreported prolonged QTc by automated ECG analysis in patients on methadone: can we rely on computer reading?
Topics: Analgesics, Opioid; Diagnosis, Computer-Assisted; Diagnostic Errors; Electrocardiography; Female; Hu | 2015 |
Methadone Recycling Sustains Drug Reservoir in Tissue.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; H | 2015 |
Methadone for Pain Relief.
Topics: Analgesics, Opioid; Drug Interactions; Humans; Methadone; Pain | 2016 |
Relationship between CYP2B6*6 and cold pressor pain sensitivity in opioid dependent patients on methadone maintenance therapy (MMT).
Topics: Adult; Alleles; Analgesics, Opioid; Cytochrome P-450 CYP2B6; Genotype; Heterozygote; Humans; Male; M | 2016 |
Trends in Methadone Distribution for Pain Treatment, Methadone Diversion, and Overdose Deaths - United States, 2002-2014.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Black or African American; Drug Overdose; Female; Hispa | 2016 |
Methadone as a Coanalgesic for Palliative Care Cancer Patients.
Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain; Palliative Care | 2016 |
Methadone analgesia in the critically ill.
Topics: Analgesia; Critical Illness; Humans; Methadone; Pain; Pain Management | 2016 |
Letter response: Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
Topics: Analgesics, Opioid; Fentanyl; Head and Neck Neoplasms; Humans; Methadone; Neuralgia; Pain; Pain Meas | 2016 |
Methadone is superior to fentanyl in treating neuropathic pain in patients with head-and-neck cancer.
Topics: Analgesics, Opioid; Fentanyl; Head and Neck Neoplasms; Humans; Methadone; Neoplasms; Neuralgia; Pain | 2016 |
Alternative analgesics: New drugs for pain seek to improve on ketamine's benefits.
Topics: Analgesics, Non-Narcotic; Animals; Complex Regional Pain Syndromes; Drug Design; Fractures, Bone; Hu | 2017 |
Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1.
Topics: Adult; Alleles; Analgesics, Opioid; Black or African American; Dose-Response Relationship, Drug; Fem | 2017 |
Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
Topics: Analgesia; Analgesics, Opioid; Animals; Catheters, Indwelling; Chemokine CX3CL1; Cytokines; Hyperalg | 2008 |
Opioid-induced pain.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; | 2008 |
Methadone: a closer look at the controversy.
Topics: Analgesics, Opioid; Humans; Methadone; Opioid-Related Disorders; Pain; Palliative Care | 2008 |
Management of acute pain in methadone maintenance therapy in-patients.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Australia; Dose-Response Relatio | 2008 |
Methadone analgesia for persistent pain: safety and toxicity considerations.
Topics: Analgesics, Opioid; Chronic Disease; Drug Interactions; Humans; Methadone; Pain | 2008 |
Methadone in internal medicine.
Topics: Analgesia; Analgesics; Humans; Internal Medicine; Methadone; Pain; Pain Management | 1948 |
The use of dolophine (dimethylamino heptanone-methadon) in the control of pain in bone and joint disorders.
Topics: Bone Diseases; Humans; Joint Diseases; Methadone; Pain | 1947 |
[Analgesics and palliative care].
Topics: Analgesics; Analgesics, Opioid; Fentanyl; Humans; Methadone; Morphine; Neoplasms; Pain; Palliative C | 2008 |
Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report.
Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Diazepam; Doxepin; | 2009 |
Urine drug testing of chronic pain patients: licit and illicit drug patterns.
Topics: Amphetamines; Analgesics, Opioid; Benzodiazepines; Cannabinoids; Carisoprodol; Chronic Disease; Huma | 2008 |
Treating opioid dependency and coexistent chronic nonmalignant pain.
Topics: Analgesics, Opioid; Buprenorphine; Chronic Disease; Humans; Methadone; Opioid-Related Disorders; Pai | 2008 |
Conversion from parenteral to oral methadone.
Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesics, Opioid; Biological Availability; Dose-Res | 2008 |
European pain management discussion forum.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Europe; Herpes Zoster; Humans; Methadone; Morphine; Neural | 2008 |
Hyperalgesia in opioid-managed chronic pain and opioid-dependent patients.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Drug Tolerance; Female; Humans; Hyperalgesia; Male; Meth | 2009 |
Providers' experiences treating chronic pain among opioid-dependent drug users.
Topics: Chronic Disease; Decision Making; Delivery of Health Care, Integrated; Humans; Methadone; Opioid-Rel | 2009 |
Methadone: an effective, safe drug of first choice for pain management in frail older adults.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Female; Frail Elderly; Homes for the A | 2009 |
Self-efficacy and depression as mediators of the relationship between pain and antiretroviral adherence.
Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Depressive Disorder; Female; HIV Infections; Humans; Male; | 2009 |
Interaction between rifampicin and methadone.
Topics: Drug Interactions; Humans; Methadone; Pain; Rifampin | 2009 |
Methadone for chronic pain in older adults: blast from the past but are we ready for it to return to prime time?
Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain | 2009 |
Methadone antinociception is dependent on peripheral opioid receptors.
Topics: Analgesics, Opioid; Animals; Drug Administration Routes; Injections, Intraventricular; Injections, S | 2009 |
Frequency, indications, outcomes, and predictive factors of opioid switching in an acute palliative care unit.
Topics: Adult; Aged; Analgesics, Opioid; Buprenorphine; Female; Fentanyl; Humans; Male; Methadone; Middle Ag | 2009 |
Documented poor sleep among methadone-maintained patients is associated with chronic pain and benzodiazepine abuse, but not with methadone dose.
Topics: Adult; Benzodiazepines; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; Male; Met | 2009 |
Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Controlled Clinic | 2009 |
Methadone for pain: limited evidence, tenuous guidelines.
Topics: Analgesics, Opioid; Humans; Methadone; Pain; Practice Guidelines as Topic | 2009 |
Use of epidurally derived evoked potentials for quantification of caudal nociception in ponies.
Topics: Analgesics, Opioid; Animals; Electric Stimulation; Electromyography; Evoked Potentials, Somatosensor | 2009 |
Relations among psychopathology, substance use, and physical pain experiences in methadone-maintained patients.
Topics: Adult; Chronic Disease; Comorbidity; Connecticut; Female; Humans; Male; Mental Disorders; Methadone; | 2009 |
Efficacy of oral sucrose in infants of methadone-maintained mothers.
Topics: Administration, Oral; Adult; Analgesia; Analgesics; Blood Specimen Collection; Female; Gestational A | 2010 |
Exploring the relationship between perceived inter-dose opioid withdrawal and patient characteristics in methadone maintenance treatment.
Topics: Adult; Affect; Anxiety; Behavior, Addictive; Female; Humans; Male; Methadone; Opioid-Related Disorde | 2009 |
Chronic pain: levorphanol, methadone, and the N-methyl-D-aspartate receptor.
Topics: Analgesics, Opioid; Chronic Disease; Hospice Care; Humans; Levorphanol; Methadone; N-Methylaspartate | 2009 |
Quantification of a methadone metabolite (EDDP) in urine: assessment of compliance.
Topics: Analgesics, Opioid; Chronic Disease; Creatinine; Female; Follow-Up Studies; Humans; Male; Methadone; | 2009 |
Methadone initiation and rotation in the outpatient setting for patients with cancer pain.
Topics: Ambulatory Care; Analgesics, Opioid; Drug Administration Schedule; Female; Humans; Male; Methadone; | 2010 |
Treatment of acute pain in opioid tolerant patients.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Drug Tolerance; Humans; | 2010 |
[Displaced pain pump because of a pendulous abdomen - dermatolipectomy as solution of the problem].
Topics: Abdominal Fat; Adult; Amides; Analgesics, Opioid; Chronic Disease; Equipment Failure Analysis; Femal | 2010 |
Methadone deaths in pain and addiction populations.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain; Palliative Care; Substance-Related Dis | 2010 |
Post-marketing surveillance of methadone and buprenorphine in the United States.
Topics: Analgesics, Opioid; Buprenorphine; Data Collection; Humans; Marketing; Methadone; Opioid-Related Dis | 2010 |
The differential effect of methadone dose and of chronic pain on pain perception of former heroin addicts receiving methadone maintenance treatment.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Chronic Disease; Dose-Response Relationship, Drug; | 2011 |
Exploring relations among traumatic, posttraumatic, and physical pain experiences in methadone-maintained patients.
Topics: Adult; Analgesics, Opioid; Cross-Sectional Studies; Female; Humans; Life Change Events; Male; Methad | 2011 |
A formal feasibility study of sublingual methadone for breakthrough cancer pain.
Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Alberta; Analgesics, Opioid; Drug Monito | 2010 |
The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Arrestins; beta-Arrestins; Drug Tolerance; Fentan | 2011 |
Self-reported side effects in buprenorphine and methadone patients receiving antiretroviral therapy: results from the MANIF 2000 cohort study.
Topics: Anti-Retroviral Agents; Attitude to Health; Buprenorphine; Cohort Studies; Depression; Female; Franc | 2010 |
Injection-related venous disease and walking mobility.
Topics: Adult; Aged; Chronic Disease; Cross-Sectional Studies; Female; Humans; Illicit Drugs; Leg Injuries; | 2010 |
Use of methadone for uncontrolled pain: an alternative dosing regimen.
Topics: Analgesics, Opioid; Drug Administration Schedule; Humans; Methadone; Pain; Treatment Outcome | 2010 |
The methadone epidemic: methadone-related deaths on the rise in Vermont.
Topics: Accidents; Adolescent; Adult; Age Distribution; Aged; Central Nervous System Depressants; Crime; Dru | 2011 |
Pain catastrophizing and pain coping among methadone-maintained patients.
Topics: Adaptation, Psychological; Adult; Catastrophization; Depression; Disability Evaluation; Employment; | 2011 |
Painkillers fuel growth in drug addiction. Opioid overdoses now kill more people than cocaine or heroin.
Topics: Analgesics, Opioid; Buprenorphine; Cocaine; Drug Overdose; Drug Prescriptions; Health Knowledge, Att | 2011 |
Evaluation of methadone absorption after topical administration to hospice patients.
Topics: Administration, Oral; Administration, Topical; Aged; Aged, 80 and over; Analgesics, Opioid; Female; | 2011 |
Effects of the delta-opioid agonist SNC80 on the abuse liability of methadone in rhesus monkeys: a behavioral economic analysis.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Cocaine; Data Interpretation, Statistic | 2011 |
Choosing the unit of measurement counts: the use of oral morphine equivalents in studies of opioid consumption is a useful addition to defined daily doses.
Topics: Administration, Oral; Analgesics, Opioid; Cooperative Behavior; Databases, Factual; Drug Utilization | 2011 |
Comparative mortality among Department of Veterans Affairs patients prescribed methadone or long-acting morphine for chronic pain.
Topics: Adult; Aged; Analgesics, Opioid; Benzodiazepines; Cohort Studies; Drug Delivery Systems; Female; Hum | 2011 |
Methadone: friend or foe?
Topics: Analgesics, Opioid; Drug Dosage Calculations; Drug Monitoring; Drug Substitution; Humans; Methadone; | 2011 |
Differential antinociceptive effects of buprenorphine and methadone in the presence of HIV-gp120.
Topics: Analgesia; Analgesics, Opioid; Animals; Buprenorphine; HIV Envelope Protein gp120; Hot Temperature; | 2011 |
Neostigmine for the treatment of gastrointestinal atony: a report of one case.
Topics: Aged; Analgesics, Opioid; Constipation; Female; Humans; Injections, Subcutaneous; Methadone; Neoplas | 2011 |
An analysis of the root causes for opioid-related overdose deaths in the United States.
Topics: Analgesics, Opioid; Comorbidity; Databases, Factual; Drug Overdose; Humans; Medication Errors; Metha | 2011 |
Opioid switching to methadone: a pharmacoepidemiological study from a national prescription database.
Topics: Adult; Aged; Analgesics, Opioid; Databases, Factual; Drug Prescriptions; Drug Substitution; Humans; | 2012 |
THC-methadone and THC-naltrexone interactions on discrimination, antinociception, and locomotion in rats.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Discrimination Learning; Disease Models, Anim | 2011 |
The effect of pain on stroop performance in patients with opiate dependence in sustained remission.
Topics: Adult; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Opioid-Related Disorders; Pain; Pain | 2011 |
Use of methadone as a coanalgesic.
Topics: Analgesics, Opioid; Humans; Methadone; Pain | 2011 |
Gabapentin as part of multi-modal analgesia in two cats suffering multiple injuries.
Topics: Amines; Analgesia; Analgesics; Animals; Buprenorphine; Cat Diseases; Cats; Cyclohexanecarboxylic Aci | 2011 |
Characterization of the antinociceptive effects of the individual isomers of methadone after acute and chronic administrations.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administ | 2011 |
Is it time to reformulate racemic methadone?
Topics: Adult; Arrhythmias, Cardiac; Chemistry, Pharmaceutical; Chronic Disease; Death, Sudden, Cardiac; Fem | 2011 |
Switching from oxycodone to methadone in advanced cancer patients.
Topics: Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Humans; Male; Methadone; Middle | 2012 |
Inconsistencies in opioid equianalgesic ratios: clinical and research implications.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Analgesics, Opioid; Delayed-Action Preparati | 2008 |
Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Dose-Response Relationship, Drug; Drug Tolerance; End | 2012 |
Transitioning a cancer patient from high-dose intravenous hydromorphone therapy to intravenous methadone.
Topics: Adult; Analgesics, Opioid; Colorectal Neoplasms; Fatal Outcome; Female; Humans; Hydromorphone; Infus | 2011 |
Practicability, safety, and efficacy of a "German model" for opioid conversion to oral levo-methadone.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Substitut | 2012 |
Stop and go strategy for opioid switching requires flexibility.
Topics: Analgesics, Opioid; Drug Substitution; Female; Humans; Male; Methadone; Morphine; Neoplasms; Oxycodo | 2012 |
Switching methadone: a 10-year experience of 345 patients in an acute palliative care unit.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Ne | 2012 |
Severe central sleep apnea in a child with leukemia on chronic methadone therapy.
Topics: Analgesics, Opioid; Child; Humans; Leukemia, Myeloid, Acute; Male; Methadone; Pain; Severity of Illn | 2013 |
Use of methadone as a coanalgesic: response to McKenna and Nicholson.
Topics: Analgesics, Opioid; Humans; Methadone; Pain | 2012 |
The disparate treatment of medications and opiate pain medications under the law: permitting the proliferation of opiates and limiting access to treatment.
Topics: Analgesics, Opioid; Buprenorphine; Drug and Narcotic Control; Drug Approval; Health Services Accessi | 2012 |
Methadone in combination with acepromazine as premedication prior to neutering in the cat.
Topics: Acepromazine; Analgesics, Opioid; Anesthesia, General; Animals; Behavior, Animal; Buprenorphine; But | 2013 |
Pain depression and sleep disorders among methadone maintenance treatment patients.
Topics: Adult; Analysis of Variance; Depressive Disorder; Female; Health Status; Humans; Male; Mental Health | 2012 |
Vital signs: risk for overdose from methadone used for pain relief - United States, 1999-2010.
Topics: Analgesics, Opioid; Drug Overdose; Guideline Adherence; Humans; Methadone; Pain; Practice Patterns, | 2012 |
Switching from methadone to tapentadol for cancer pain.
Topics: Aged; Analgesics, Opioid; Female; Humans; Methadone; Multiple Myeloma; Neoplasms; Pain; Phenols; Tap | 2012 |
Methadone overdose deaths rise with increased prescribing for pain.
Topics: Analgesics, Opioid; Drug Costs; Drug Overdose; Formularies as Topic; Humans; Medicaid; Methadone; Mo | 2012 |
Prescription patterns of pain medicine physicians.
Topics: Acetaminophen; Analgesics; Analgesics, Opioid; Drug Prescriptions; Humans; Methadone; Opioid-Related | 2013 |
Addition of methadone to another opioid in the management of moderate to severe cancer pain: a case series.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Neoplasms | 2013 |
Successful use of oral methadone after failure of intravenous morphine and ketamine.
Topics: Acute Disease; Administration, Oral; Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, O | 2002 |
Torsade de pointes associated with very-high-dose methadone.
Topics: Adult; Analgesics, Opioid; Canada; Chronic Disease; Electrocardiography; Female; Heroin Dependence; | 2002 |
Summaries for patients. Very high doses of methadone may cause abnormal heart rhythm.
Topics: Adult; Analgesics, Opioid; Canada; Chronic Disease; Female; Heroin Dependence; Humans; Male; Methado | 2002 |
Therapy of chronic non-malignant pain with opioids.
Topics: Analgesics, Opioid; Humans; Methadone; Middle Aged; Pain; Tramadol | 2003 |
An ad libitum schedule for conversion of morphine to methadone in advanced cancer patients: an open uncontrolled prospective study in a Chinese population.
Topics: Administration, Oral; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; China; Drug Ad | 2003 |
Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Multivaria | 2003 |
Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Multivaria | 2003 |
Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Multivaria | 2003 |
Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Multivaria | 2003 |
Ultra-low dose oral naltrexone decreases side effects and potentiates the effect of methadone.
Topics: Administration, Oral; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Interactions; Human | 2003 |
High dose methadone and ventricular arrhythmias: a report of three cases.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Arrhythmias, Cardiac; Drug Interactions; Heart Vent | 2003 |
Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Hypokalemia; Lon | 2003 |
The trend to move palliative care upstream.
Topics: Acetates; Adult; Amines; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; H | 2003 |
Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone.
Topics: Aminopeptidases; Analgesics; Animals; Disease Management; Dose-Response Relationship, Drug; Drug Syn | 2003 |
Medico-legal rounds: medico-legal issues and alleged breaches of "standards of medical care" in opioid rotation to methadone: a case report.
Topics: Adult; Analgesics, Opioid; Autopsy; Chronic Disease; Decision Making; Expert Testimony; Florida; Hum | 2003 |
Parenteral methadone: an essential medication for the treatment of pain.
Topics: Analgesics, Opioid; Humans; Infusions, Parenteral; Methadone; Pain | 2003 |
Methadone and the hospice patient: prescribing trends in the home-care setting.
Topics: Analgesics, Opioid; Drug Prescriptions; Drug Utilization; Female; Home Care Services; Hospice Care; | 2003 |
Drug addiction and other considerations in the management of pain with narcotic drugs.
Topics: Behavior, Addictive; Humans; Meperidine; Methadone; Morphine Dependence; Morphine Derivatives; Narco | 1957 |
Drug addiction and other considerations in the management of pain with narcotic drugs.
Topics: Behavior, Addictive; Humans; Meperidine; Methadone; Morphine Dependence; Morphine Derivatives; Narco | 1957 |
Drug addiction and other considerations in the management of pain with narcotic drugs.
Topics: Behavior, Addictive; Humans; Meperidine; Methadone; Morphine Dependence; Morphine Derivatives; Narco | 1957 |
Drug addiction and other considerations in the management of pain with narcotic drugs.
Topics: Behavior, Addictive; Humans; Meperidine; Methadone; Morphine Dependence; Morphine Derivatives; Narco | 1957 |
Analgesic activity of dipipanone hydrochloride in student volunteers.
Topics: Analgesics; Humans; Methadone; Pain; Pain Threshold; Students; Volunteers | 1957 |
Comparative effects of analgesics on pain threshold, respiratory frequency and gastrointestinal propulsion.
Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Antipyretics; Cell Respiration; C | 1959 |
Analgesia in electromyography.
Topics: Analgesia; Electromyography; Humans; Meperidine; Methadone; Pain; Pain Management; Promethazine | 1963 |
DOUBLE BLIND TRIAL OF DEXTROMORAMIDE, METHADONE AND PETHIDINE IN THE TREATMENT OF SEVERE PAIN.
Topics: Dextromoramide; Double-Blind Method; Humans; Meperidine; Methadone; Pain; Toxicology | 1964 |
ANALGESICS FOR THE RELIEF OF PAIN. I. NARCOTIC ANALGESICS.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Codeine; Humans; Hydromorphone; Meperidine; Meth | 1964 |
A CLINICAL TRIAL OF A MIXTURE OF LEVORPHANOL AND LEVALLORPHAN AS AN ORAL ANALEGESIC.
Topics: Drug Therapy; Humans; Levallorphan; Levorphanol; Methadone; Neoplasms; Osteoarthritis; Pain; Substan | 1964 |
THE IMPORTANCE OF STERIC CONFIGUA. ION IN CERTAIN MORPHINNE-MIMETIC ACTIONS OF SYNTHETIC ANALGETICS.
Topics: Analgesics; Analgesics, Non-Narcotic; Antipyretics; Apnea; Chemical Phenomena; Chemistry; Methadone; | 1964 |
[ANALGESIA FOLLOWING GYNECOLOGICAL OPERATIONS].
Topics: Analgesia; Drug Therapy; Female; Genital Diseases, Female; Humans; Meperidine; Methadone; Pain; Phen | 1965 |
[Analgetic effect of morphine, dolsin and mecodin in various ways of application; a pharmacological study].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Meperidine; Methadone; Morphine; Pain; Pain Managem | 1955 |
QTc interval prolongation associated with intravenous methadone.
Topics: Cell Line; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Infusions, Intrave | 2003 |
Methadone maintenance therapy and chronic pain.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain; Substance Abuse Treatment Centers; Sub | 2003 |
Use of methadone for neuropathic pain.
Topics: Clinical Trials as Topic; Humans; Methadone; Pain | 2003 |
Treatment needs associated with pain in substance use disorder patients: implications for concurrent treatment.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Chronic Disease; Comorbidity; Cross-Sectional Studi | 2004 |
Outcomes of infants born to mothers receiving methadone for pain management in pregnancy.
Topics: Analgesics, Opioid; Chronic Disease; Delivery, Obstetric; Drug Administration Schedule; Female; Gest | 2004 |
Prescription opioid abuse in patients presenting for methadone maintenance treatment.
Topics: Adult; Comorbidity; Drug Prescriptions; Female; Humans; Male; Mental Disorders; Methadone; Narcotics | 2004 |
Opioid therapy in patients with a history of substance abuse.
Topics: Chronic Disease; Drug Administration Schedule; Drug Tolerance; Humans; Medical History Taking; Metha | 2004 |
A comparison of heat and pressure analgesiometric methods in rats.
Topics: Animals; Hot Temperature; Methadone; Morphine; Pain; Pressure; Rats | 1951 |
Switching to methadone: 'ad libitum' or fixed dose ratio?
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Morphine; Neoplasms; Pain; Patient Satisfact | 2004 |
Sleep disturbances among methadone maintained patients.
Topics: Adult; Alcohol Drinking; Female; Humans; Least-Squares Analysis; Male; Methadone; Opioid-Related Dis | 2004 |
Of "blind dosing" and detoxification: justifiable or ill conceived?
Topics: Adult; Analgesics, Opioid; Deception; Disclosure; Heroin Dependence; Humans; Informed Consent; Male; | 2001 |
Methadone for pain: No. 75.
Topics: Administration, Oral; Analgesics, Opioid; Humans; Methadone; Pain; Palliative Care | 2004 |
Methadone: starting dosing information No. 86.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Methadone; Pain; Palliative Care; Prac | 2004 |
(S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone.
Topics: Analgesics, Opioid; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Immunosupp | 2004 |
[Polamidon as a spasmolytic and analgesic].
Topics: Analgesics; Humans; Methadone; Morphine; Pain; Parasympatholytics; Spasm | 1950 |
Oral methadone for cancer pain: no indication of Q-T interval prolongation or torsades de pointes.
Topics: Analgesics, Opioid; Arrhythmias, Cardiac; Electrocardiography; Heart Rate; Humans; Methadone; Neopla | 2004 |
The experience of chronic severe pain in patients undergoing methadone maintenance treatment.
Topics: Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Middle Aged; Pain; Self Care; | 2004 |
Successful treatment of hydromorphone-induced neurotoxicity and hyperalgesia.
Topics: Humans; Hydromorphone; Hyperalgesia; Male; Methadone; Middle Aged; Narcotics; Neurotoxicity Syndrome | 2004 |
Diversion and abuse of methadone prescribed for pain management.
Topics: Analgesics, Opioid; Drug and Narcotic Control; Drug Prescriptions; Humans; Methadone; Opioid-Related | 2005 |
Profound morphine tolerance following high-dose methadone therapy.
Topics: Analgesics; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Male; Methadone; Middle Aged; | 2004 |
Methadone-related Torsades de Pointes in a sickle cell patient treated for chronic pain.
Topics: Adult; Analgesics, Opioid; Anemia, Sickle Cell; Humans; Male; Methadone; Pain; Torsades de Pointes | 2005 |
[Oral pain and loss of teeth in a 36-year-old woman].
Topics: Adult; Anti-Bacterial Agents; Antiretroviral Therapy, Highly Active; Combined Modality Therapy; Debr | 2005 |
Opioid rotation from methadone: fraught with difficulties.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Live | 2005 |
Torsades de pointes with methadone.
Topics: Analgesics, Opioid; Aryl Hydrocarbon Hydroxylases; Drug Interactions; Heroin; Humans; Hypokalemia; L | 2005 |
Methadone treatment of chronic non-malignant pain and opioid dependence--a long-term follow-up.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Drug Administration Schedule; Female; Follow-Up St | 2006 |
Comparative actions of the opioid analgesics morphine, methadone and codeine in rat models of peripheral and central neuropathic pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Codeine; Disease Models, Animal; Male; Methadone; Mor | 2005 |
Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice.
Topics: Analgesia; Analgesics, Opioid; Animals; Central Nervous System; Dose-Response Relationship, Drug; Dr | 2005 |
Dextromethorphan-induced delirium and possible methadone interaction.
Topics: Aged; Analgesics, Opioid; Antitussive Agents; Cough; Delirium; Depressive Disorder; Dextromethorphan | 2005 |
Response to methadone maintenance treatment of opiate dependent patients with and without significant pain.
Topics: Adult; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; P | 2006 |
Methadone for neuropathic pain: a new use for an old drug?
Topics: Analgesics, Opioid; Excitatory Amino Acid Antagonists; Humans; Methadone; Pain; Peripheral Nervous S | 2005 |
Prescribing methadone as an analgesic.
Topics: Analgesics; Chronic Disease; Drug Administration Schedule; Half-Life; Humans; Methadone; Pain | 2005 |
Methadone--an old analgesic with new tricks.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain | 2005 |
Methadone titration: still no gauge on the tank.
Topics: Analgesics, Opioid; Carcinoma, Small Cell; Drug Administration Schedule; Humans; Lung Neoplasms; Mal | 2005 |
Methadone: a double edged sword.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain | 2005 |
Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Chronic Disease; Delayed-Action Preparations; | 2006 |
Response phases in methadone treatment for chronic nonmalignant pain.
Topics: Adaptation, Psychological; Adult; Analgesics, Opioid; Causality; Chronic Disease; Family; Female; He | 2006 |
Prescription drug dependence and evolving beliefs about chronic pain management.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Drug Prescriptions; Drug Tolerance; Drug Utilization; Fe | 2006 |
ME Lynch. A review of the use of methadone for the treatment of chronic noncancer pain. Pain Res Manage 2005;10(3):133-44.
Topics: Analgesics, Opioid; Drug Therapy, Combination; Humans; Methadone; Pain | 2006 |
Rotating methadone to other opioids: a lesson in the mechanisms of opioid tolerance and opioid-induced pain.
Topics: Adult; Drug Tolerance; Humans; Hyperalgesia; Male; Methadone; Narcotics; Pain; Receptors, N-Methyl-D | 2006 |
Morphine, oxycodone, methadone and its enantiomers in different models of nociception in the rat.
Topics: Acute Disease; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Male; Methadone; Morph | 2006 |
Pharmacokinetics and pharmacodynamics of methadone enantiomers in hospice patients with cancer pain.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chromatography, High Pressure Liquid; Female; Ha | 2006 |
Anesthesia and pain management for pediatric patients with dystrophic epidermolysis bullosa.
Topics: Adolescent; Anesthesia, General; Child; Child, Preschool; Conscious Sedation; Epidermolysis Bullosa | 2006 |
Methadone-induced respiratory depression after discontinuing carbamazepine administration.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Carbamazepine; Female; Humans; Methadone; Middle Aged; | 2006 |
[Opioid switching and methadone in pain relief].
Topics: Analgesics, Opioid; Drug Administration Schedule; Drug Tolerance; Humans; Methadone; Pain | 2006 |
Letter to the editor regarding Sullivan et al.
Topics: Analgesics, Opioid; Humans; Internship and Residency; Methadone; Pain | 2006 |
Trends and geographic variation of opiate medication use in state Medicaid fee-for-service programs, 1996 to 2002.
Topics: Analgesics, Opioid; Data Interpretation, Statistical; Drug Prescriptions; Drug Utilization; Fee-for- | 2006 |
Effects of subcutaneous methadone, morphine, buprenorphine or saline on thermal and pressure thresholds in cats.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Cats; Female; Hot Temperature; Injections, Subcutaneous; | 2006 |
Equianalgesic dosing of opioids.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Fentanyl; Humans; Hydromorphone; Methadone; Pa | 2006 |
Herbal product use in a patient with polypharmacy.
Topics: Aged; Analgesics, Opioid; Dizziness; Herb-Drug Interactions; Humans; Hypotension, Orthostatic; Male; | 2006 |
Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics.
Topics: Adenosine; Analgesics, Opioid; Animals; Clonidine; Dose-Response Relationship, Drug; Fentanyl; Heroi | 2007 |
Regarding naltrexone for probationers and parolees.
Topics: Buprenorphine; Heroin Dependence; Humans; Injections; Long-Term Care; Methadone; Naltrexone; Narcoti | 2007 |
Medicating "Margaret".
Topics: Advance Directives; Alzheimer Disease; Analgesics, Opioid; Antipsychotic Agents; Electroconvulsive T | 2006 |
Prescription opioid abuse among enrollees into methadone maintenance treatment.
Topics: Adult; Analgesics, Opioid; Comorbidity; Cross-Sectional Studies; Drug Prescriptions; Female; Health | 2007 |
[Methadone in the treatment of chronic non-malignant pain].
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone | 2007 |
Nurse case management program of chronic pain patients treated with methadone.
Topics: Aged; Ambulatory Care; Analgesics, Opioid; Case Management; Chronic Disease; Drug Monitoring; Feasib | 2007 |
Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone.
Topics: Adult; Alleles; Analgesics, Opioid; Cytochrome P-450 CYP2D6; Female; Genotype; Humans; Male; Methado | 2007 |
Prescription opioid use, misuse, and diversion among street drug users in New York City.
Topics: Administration, Intranasal; Adult; Aged; Analgesics, Opioid; Buprenorphine; Cocaine-Related Disorder | 2008 |
Patient versus therapist alliance: whose perception matters?
Topics: Adult; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; P | 2008 |
Prescribing methadone for pain management in end-of-life care.
Topics: Drug Interactions; Humans; Methadone; Morphine; Pain; Palliative Care; Terminal Care | 2005 |
The safety of methadone hydrochloride.
Topics: Animals; Humans; Methadone; Opioid-Related Disorders; Pain; Respiratory Insufficiency | 2008 |
High dose levo-methadone treatment for cancer pain in a patient with a history of drug addiction.
Topics: Adult; Analgesics, Opioid; Carcinoma, Squamous Cell; Female; Humans; Methadone; Opioid-Related Disor | 2008 |
Managing an acute pain crisis in a patient with advanced cancer: "this is as much of a crisis as a code".
Topics: Acute Disease; Adenocarcinoma, Mucinous; Adjuvants, Anesthesia; Adult; Analgesics, Opioid; Anestheti | 2008 |
MMTP patients with chronic pain switching to pain management clinics. A problem or an acceptable practice?
Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Heroin Dependence; Humans; Male; Methadone; Midd | 2008 |
Actual and potential drug interactions associated with methadone.
Topics: Analgesics, Opioid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Drug Interactions; Humans; Meth | 2008 |
Re: subcutaneous methadone-an issue revisited.
Topics: Analgesics, Opioid; Humans; Infusions, Parenteral; Injections, Subcutaneous; Methadone; Pain | 2008 |
Increased assessment and monitoring needed for patients receiving methadone.
Topics: Analgesics, Opioid; Humans; Methadone; Opioid-Related Disorders; Pain | 2008 |
Chronic pain in patients with substance abuse disorder: general guidelines and an approach to treatment.
Topics: Chronic Disease; Diagnosis, Differential; Humans; Methadone; Pain; Substance-Related Disorders | 2008 |
Substitution-detoxification and its role in the management of chronic benign pain.
Topics: Acute Disease; Analgesics, Opioid; Chronic Disease; Drug Administration Schedule; Humans; Hypnotics | 1982 |
(-)-alpha-Acetylmethadol for treatment of chronic pain patients who abuse opioids.
Topics: Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; Methadyl Acetate; Middl | 1983 |
Should regional anesthesia and pharmacological agents such as beta blockers and opiates be utilized in modulating pain response?
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alfentanil; Analgesia; Analgesics; Anesth | 1984 |
[Peroral analgetic treatment with a methadone mixture in terminal cancer patients].
Topics: Administration, Oral; Aged; Female; Humans; Male; Methadone; Middle Aged; Neoplasms; Pain; Palliativ | 1981 |
[Long-lasting pain relief with rectal methadone therapy].
Topics: Aged; Female; Humans; Male; Methadone; Neoplasms; Pain; Palliative Care; Rectum; Suppositories | 1983 |
A comparison of antinociception induced by foot shock and morphine.
Topics: Animals; Cyclazocine; Electroshock; Foot; Male; Methadone; Morphine; Naloxone; Nociceptors; Pain; Pe | 1983 |
A modified submaximal effort tourniquet test for evaluation of analgesics in healthy volunteers.
Topics: Adult; Analgesics; Arm; Bloodletting; Double-Blind Method; Female; Humans; Male; Methadone; Middle A | 1984 |
Pharmacist intervention in methadone administration to cancer patients with chronic pain.
Topics: Adolescent; Adult; Aged; Chronic Disease; Humans; Methadone; Middle Aged; Neoplasms; Pain; Pharmacis | 1983 |
A study of hospitalized surgical patients on methadone maintenance.
Topics: Adult; Analgesics; Female; Humans; Male; Methadone; Pain; Patient Admission; Surgical Procedures, Op | 1981 |
Cimetidine potentiation of narcotic action.
Topics: Adenocarcinoma; Aged; Cimetidine; Drug Synergism; Guanidines; Humans; Lung Neoplasms; Male; Methadon | 1983 |
[Morphine and methadone in severe cancer pain--new pharmacokinetic bases for optimal therapy].
Topics: Chronic Disease; Humans; Kinetics; Methadone; Morphine; Neoplasms; Pain | 1983 |
How to use methadone. A handbook for patients and families.
Topics: Humans; Methadone; Neoplasms; Pain; Patient Education as Topic; Self Administration | 1981 |
The antinociceptive effects of epidural opiates in the cat: studies of the pharmacology and the effects of lipophilicity in spinal analgesia.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Epidural Space; Female; Fentanyl; Lipids; Male; Mep | 1982 |
Pain control in advanced and recurrent head and neck cancer.
Topics: Dextroamphetamine; Drug Therapy, Combination; Electrocoagulation; Head and Neck Neoplasms; Humans; M | 1980 |
Dantrolene treatment of opioid-induced myoclonus.
Topics: Aged; Analgesics, Opioid; Dantrolene; Humans; Male; Methadone; Middle Aged; Morphine; Muscle Relaxan | 1995 |
A four-drug pain regimen for head and neck cancers.
Topics: Acetaminophen; Adult; Aged; Antidepressive Agents, Tricyclic; Drug Administration Schedule; Drug The | 1994 |
Respiratory depression in a patient receiving oral methadone for cancer pain.
Topics: Administration, Oral; Female; Humans; Methadone; Middle Aged; Neoplasms; Pain; Respiration Disorders | 1995 |
Disappearance of morphine-induced hyperalgesia after discontinuing or substituting morphine with other opioid agonists.
Topics: Adult; Aged; Analgesics, Opioid; Child; Delayed-Action Preparations; Female; Humans; Hyperalgesia; M | 1994 |
Methadone in pain uncontrolled by morphine.
Topics: Adult; Female; Humans; Methadone; Morphine; Pain | 1993 |
Methadone therapy.
Topics: HIV Infections; Humans; Methadone; Opioid-Related Disorders; Pain | 1993 |
CSF neuropeptides in cancer pain: effects of spinal opioid therapy.
Topics: Aged; Bupivacaine; Female; Humans; Injections, Epidural; Injections, Spinal; Male; Methadone; Middle | 1993 |
Rapid determination of methadone in plasma, cerebrospinal fluid, and urine by gas chromatography and its application to routine drug monitoring.
Topics: Chromatography, Gas; Chronic Disease; Drug Monitoring; Heroin Dependence; Humans; Methadone; Pain; Q | 1993 |
Rectal methadone in cancer patients with pain. A preliminary clinical and pharmacokinetic study.
Topics: Administration, Rectal; Adult; Analgesics, Opioid; Colorectal Neoplasms; Female; Head and Neck Neopl | 1995 |
Oral methadone for managing chronic nonmalignant pain.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Chronic Disease; Female; Humans; Male; Methadone; M | 1996 |
Opioid rotation in patients with cancer pain. A retrospective comparison of dose ratios between methadone, hydromorphone, and morphine.
Topics: Administration, Oral; Aged; Aged, 80 and over; Analgesics, Opioid; Cohort Studies; Dose-Response Rel | 1996 |
Clinical experience with oral methadone administration in the treatment of pain in 196 advanced cancer patients.
Topics: Administration, Oral; Aged; Analgesics, Opioid; Female; Humans; Male; Methadone; Middle Aged; Neopla | 1996 |
Individualized use of methadone and opioid rotation in the comprehensive management of cancer pain associated with poor prognostic indicators.
Topics: Carcinoma, Renal Cell; Drug Administration Schedule; Humans; Hydromorphone; Kidney Neoplasms; Male; | 1996 |
International opioid consumption.
Topics: Analgesics, Opioid; Denmark; Drug Utilization; Humans; Meperidine; Methadone; Morphine; Pain | 1997 |
Pharmacologic treatment of cancer pain.
Topics: Analgesics, Opioid; Humans; Methadone; Morphine; Neoplasms; Pain; Therapeutic Equivalency | 1997 |
Intravenous methadone for cancer pain unrelieved by morphine and hydromorphone: clinical observations.
Topics: Adult; Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Hydromorphone; Injections, Intr | 1997 |
[Pain, anesthesia and drug addiction].
Topics: Anesthesia; Comprehensive Health Care; Heroin; Heroin Dependence; Humans; Methadone; Morphine; Narco | 1997 |
Intravenous high-dose methadone administered by patient controlled analgesia and continuous infusion for the treatment of cancer pain refractory to high-dose morphine.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Dose-Response Relationship, Drug; Humans; Infusio | 1997 |
Dose ratio between morphine and methadone in patients with cancer pain: a retrospective study.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; Drug Admini | 1998 |
Equianalgesic dose/ratio between methadone and other opioid agonists in cancer pain: comparison of two clinical experiences.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Dose-Response Relationship, Drug; | 1998 |
Substitution of another opioid for morphine. Methadone can be used to manage neuropathic pain related to cancer.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Humans; Ketamine; Methadone; N-Methylaspartate; Neopl | 1998 |
Drugs for pain.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics | 1998 |
Methadone: opioid, N-methyl-D-aspartate antagonist or both?
Topics: Analgesics, Opioid; Humans; Methadone; N-Methylaspartate; Narcotics; Pain; Receptors, N-Methyl-D-Asp | 1998 |
Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?
Topics: Administration, Oral; Aged; Analgesia; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Re | 1998 |
Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?
Topics: Administration, Oral; Aged; Analgesia; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Re | 1998 |
Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?
Topics: Administration, Oral; Aged; Analgesia; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Re | 1998 |
Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio?
Topics: Administration, Oral; Aged; Analgesia; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Re | 1998 |
Oral methadone for the treatment of severe pain in hospitalized children: a report of five cases.
Topics: Administration, Oral; Analgesia, Patient-Controlled; Analgesics, Opioid; Burns; Child; Child, Presch | 1998 |
Opioid substitution to reduce adverse effects in cancer pain management.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Female; Fentanyl; Hospice Care; Humans; Male; Medical A | 1999 |
Enantioselective high-performance liquid chromatographic method for the determination of methadone and its main metabolite in urine using an AGP and a C8 column coupled serially.
Topics: Chromatography, High Pressure Liquid; Humans; Methadone; Pain; Reproducibility of Results; Sensitivi | 1999 |
The relationship between the visual analog pain intensity and pain relief scale changes during analgesic drug studies in chronic pain patients.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Female; Humans; Hydromorphone; Male; Methadone; Mi | 1999 |
Rapid switching from morphine to methadone in cancer patients with poor response to morphine.
Topics: Aged; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans; | 1999 |
Rapid switching from morphine to methadone in cancer patients with poor response to morphine.
Topics: Aged; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans; | 1999 |
Rapid switching from morphine to methadone in cancer patients with poor response to morphine.
Topics: Aged; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans; | 1999 |
Rapid switching from morphine to methadone in cancer patients with poor response to morphine.
Topics: Aged; Analgesics, Opioid; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Humans; | 1999 |
Methadone treatment.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pain; P | 1999 |
Characteristics of methadone maintenance patients with chronic pain.
Topics: Adult; Aged; Analgesics, Opioid; Chronic Disease; Female; Humans; Interviews as Topic; Male; Methado | 2000 |
Use of methadone.
Topics: Analgesics, Opioid; Drug Interactions; Female; Humans; Infant, Newborn; Methadone; Narcotics; Neonat | 2000 |
Pain management in patients with advanced cancer.
Topics: Analgesics, Opioid; Humans; Methadone; Neoplasms; Pain | 2000 |
Respiratory depression during methadone rotation in a patient with advanced cancer.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Humans; Lung Neoplasms; Male; Methadone; Neoplasms; Pai | 2000 |
Managing constipation that's opioid-induced.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Breast Neoplasms; Chemistry, Pharmaceutical; Consti | 2000 |
The merits of methadone.
Topics: Adult; Analgesics, Opioid; Child; Child, Preschool; Chronic Disease; Humans; Methadone; Morphine; Ne | 2000 |
The N-methyl-D-aspartate antagonistic and opioid components of d-methadone antinociception in the rat spinal cord.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesia; Analgesics, | 2000 |
Morphine and alternative opioids in cancer pain: the EAPC recommendations.
Topics: Administration, Oral; Analgesics, Opioid; Chemistry, Pharmaceutical; Drug Administration Schedule; F | 2001 |
Methadone in treatment of tenesmus not responding to morphine escalation.
Topics: Aged; Analgesics, Opioid; Anus Diseases; Defecation; Humans; Male; Methadone; Morphine; Pain; Rectal | 2001 |
Methadone and cipro interaction.
Topics: Analgesics, Opioid; Anti-Infective Agents; Ciprofloxacin; Confusion; Drug Synergism; Female; Humans; | 2001 |
Opioids in chronic non-malignant pain. Don't forget methadone for chronic pain.
Topics: Analgesics, Opioid; Chronic Disease; Humans; Methadone; Pain | 2001 |
Opioid therapy for chronic painful conditions.
Topics: Analgesics, Opioid; Chronic Disease; Clinical Trials as Topic; Fentanyl; Humans; Karnofsky Performan | 2001 |
Methadone is safe for treating hospitalized patients with severe pain.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Child; Child | 2001 |
Methadone: the question or the answer for US opioid therapy and pharmaco-economics?
Topics: Analgesics, Opioid; Humans; Methadone; Models, Theoretical; Neoplasms; Opioid-Related Disorders; Pai | 2001 |
Neurologic complications including paralysis after a medication error involving implanted intrathecal catheters.
Topics: Adult; Aged; Analgesics, Opioid; Catheters, Indwelling; Cluster Analysis; Cohort Studies; Disease Ou | 2002 |
Methadone for refractory cancer pain.
Topics: Analgesics, Opioid; Carcinoma; Humans; Male; Methadone; Middle Aged; Pain; Rectal Neoplasms | 2002 |
Slow metabolism and long half life of methadone in a patient with lung cancer and cirrhosis.
Topics: Adenocarcinoma; Adult; Analgesics, Opioid; Fibrosis; Half-Life; Humans; Lung Neoplasms; Male; Metabo | 2001 |
Opioid rotation to methadone: proceed with caution.
Topics: Analgesics, Opioid; Brachial Plexus Neuropathies; Humans; Methadone; Pain; Pancoast Syndrome | 2002 |
Differential antinociception by morphine and methadone in two sub-strains of Sprague-Dawley rats and its potentiation by dextromethorphan.
Topics: Analgesics, Opioid; Animals; Catalepsy; Central Nervous System; Dextromethorphan; Dose-Response Rela | 2002 |
Effect of narcotic analgesics on the striatal homovanillic acid content in mice; relation to antinociceptive effect.
Topics: Analgesics, Opioid; Animals; Body Temperature; Corpus Striatum; Cyclazocine; Haloperidol; Homovanill | 1976 |
Analgesic drugs in the management of pain.
Topics: Analgesics; Anti-Anxiety Agents; Aspirin; Carbamazepine; Codeine; Dextropropoxyphene; Humans; Hypnot | 1977 |
Studies on tolerance development to single doses of morphine in mice.
Topics: 5,6-Dihydroxytryptamine; Animals; Brain; Cyclic AMP; Cycloheximide; Drug Tolerance; Female; Humans; | 1976 |
Important clinical pharmacologic considerations in the use of methadone in cancer patients.
Topics: Adult; Aged; Drug Administration Schedule; Female; Humans; Male; Methadone; Middle Aged; Neoplasms; | 1979 |
Pain perception in drug-free and in methadone-maintained human ex-addicts.
Topics: Adult; Blood Pressure; Cold Temperature; Female; Humans; Informed Consent; Male; Methadone; Pain; Su | 1979 |
Objective tests of analgesic drugs in ponies.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Fentanyl; Horse Diseases; Horses; Male; Meperid | 1979 |
Iatrogenic addiction and its treatment.
Topics: Adult; Aged; Behavior Therapy; Denial, Psychological; Female; Humans; Iatrogenic Disease; Life Style | 1978 |
Shattering myths about hospice care.
Topics: Hospices; Humans; Methadone; Morphine; Pain; Terminal Care | 1978 |
Methadone for pain.
Topics: Administration, Oral; Biological Availability; Humans; Methadone; Pain | 1978 |
Morphine: ability to block neuronal activity evoked by a nociceptive stimulus.
Topics: Action Potentials; Animals; Brain Stem; Chlorpromazine; Levorphanol; Male; Methadone; Morphine; Nalo | 1976 |
Drug use and distribution in a pain rehabilitation center.
Topics: Adult; Amitriptyline; Barbiturates; Chronic Disease; Diet; Female; Formularies, Hospital as Topic; H | 1975 |
Synthesis of alpha-1-noracetylmethadol. A facile N-demethylation of alpha-1-acetylmethadol.
Topics: Animals; Dealkylation; Methadone; Methadyl Acetate; Mice; Pain; Reaction Time | 1975 |
Letter: Drug use in a pain rehabilitation center.
Topics: Amitriptyline; Chronic Disease; Drug Combinations; Humans; Methadone; Pain; Phenytoin; Snake Venoms | 1975 |
Custom-made suppositories of methadone for severe cancer pain.
Topics: Administration, Rectal; Aged; Bone Neoplasms; Humans; Male; Methadone; Pain; Prostatic Neoplasms; Su | 1992 |
High-dose methadone and the need for drug measurements in plasma.
Topics: Adult; Chromatography, High Pressure Liquid; Humans; Male; Methadone; Pain; Substance Abuse Treatmen | 1991 |
Treatment of severe cancer pain by continuous infusion of subcutaneous opioids.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Female; Humans; Male; Methadone; Middle A | 1991 |
Exceptionally high narcotic analgesic requirements in a terminally ill cancer patient.
Topics: Adult; Analgesics, Opioid; Combined Modality Therapy; Drug Tolerance; Female; Humans; Hydromorphone; | 1986 |
Epidural methadone for analgesic management of patients with conservatively treated proximal femoral fractures.
Topics: Aged; Aged, 80 and over; Emergencies; Female; Femoral Neck Fractures; Humans; Injections, Epidural; | 1989 |
Medication management in patients with chronic non-malignant pain. A review of the use of a drug withdrawal protocol.
Topics: Analgesics, Opioid; Chronic Disease; Drug Combinations; Humans; Hypnotics and Sedatives; Methadone; | 1986 |
Naltrexone.
Topics: Humans; Methadone; Naltrexone; Opioid-Related Disorders; Pain; Pituitary Gland; Receptors, Opioid; S | 1985 |
[3-step pharmacologic treatment of pain in cancer. Preliminary experience in Chile].
Topics: Acetaminophen; Adult; Analgesics; Chile; Codeine; Drug Administration Schedule; Female; Follow-Up St | 1988 |
The use of methadone in opioid-tolerant patients.
Topics: Adenocarcinoma; Drug Tolerance; Fallopian Tube Neoplasms; Female; Humans; Methadone; Middle Aged; Pa | 1988 |
Methadone: pluses and minuses.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Dose-Response Relationship, Drug; Female; Humans; M | 1987 |
The availability of narcotics and attitudes towards their use.
Topics: Adrenal Gland Neoplasms; Child, Preschool; Female; Humans; Methadone; Morphine; Neuroblastoma; Pain | 1986 |
Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain.
Topics: Adult; Aged; Blood Pressure; Blood Proteins; Chronic Disease; Female; Half-Life; Humans; Kinetics; M | 1987 |
Dilemmas in managing prostate carcinoma (Part II): Metastatic disease.
Topics: Aged; Aminoglutethimide; Aspirin; Bone Neoplasms; Castration; Diethylstilbestrol; Disseminated Intra | 1985 |
The graded and quantal nature of opioid analgesia in the rat tailflick assay.
Topics: Animals; Dose-Response Relationship, Drug; Kinetics; Male; Methadone; Morphine; Pain; Rats; Reaction | 1985 |
[Analgesia in myocardial infarct].
Topics: Analgesics; Diazepam; Heart; Hemodynamics; Heroin; Humans; Hydromorphone; Meperidine; Methadone; Mor | 1974 |
Methadone in the relief of pain--a clinical note.
Topics: Humans; Methadone; Pain; Palliative Care | 1967 |
[Pain in the maxillo-facial region. Diagnosis and therapy].
Topics: Adult; Apicoectomy; Dental Amalgam; Dry Socket; Facial Neuralgia; Humans; Methadone; Middle Aged; Mo | 1972 |
The new methadone regulations.
Topics: Community Pharmacy Services; Heroin; Heroin Dependence; Humans; Legislation, Drug; Methadone; Pain; | 1973 |
Analgesics and other drugs for relief of pain.
Topics: Analgesics; Aspirin; Azepines; Carbamazepine; Codeine; Dextropropoxyphene; Humans; Indomethacin; Met | 1973 |
Surgical management of pain in cancer of the head and neck.
Topics: Alcohols; Autonomic Nerve Block; Carbamazepine; Chlorpromazine; Cranial Nerves; Gastrostomy; Head; H | 1973 |
Methadone maintenance.
Topics: Humans; Methadone; Pain; Substance-Related Disorders | 1973 |
Anti-nociceptive activity of some thiophthalanes with morphine-like properties.
Topics: Analgesia; Analgesics; Animals; Bridged-Ring Compounds; Depression, Chemical; Dextropropoxyphene; Di | 1973 |
Drug injection injuries of the hands and forearms in addicts.
Topics: Adolescent; Adult; Cocaine; Edema; Female; Forearm Injuries; Gangrene; Hand Injuries; Heparin; Heroi | 1974 |
Methadone maintenance therapy for heroin addiction. Some surgical considerations.
Topics: Adult; Cardiac Surgical Procedures; Curettage; Dextropropoxyphene; Dilatation; Female; Fracture Fixa | 1972 |
A gas-liquid chromatographic method for the quantitative determination of methadone in human plasma and urine.
Topics: Chromatography, Gas; Humans; Methadone; Methods; Neoplasms; Pain; Time Factors | 1972 |
A look at narcotic and nonnarcotic analgesics.
Topics: Analgesics; Dextropropoxyphene; Drug Antagonism; Drug Combinations; Drug Prescriptions; Drug Toleran | 1971 |
Narcotics and medical practice. Medical use of morphine and morphine-like drugs and management of persons dependent on them.
Topics: American Medical Association; Female; Health Education; Heroin; Humans; Legislation, Drug; Methadone | 1971 |
[Principles and risks of drug treatment of pain].
Topics: Aminopyrine; Analgesics; Antidepressive Agents; Antipyrine; Aspirin; Codeine; Dibenzazepines; Humans | 1969 |
Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor.
Topics: Analgesia; Animals; Brain; Codeine; Dextropropoxyphene; Electroshock; Male; Methadone; Morphine; Pai | 1968 |
[Research on the placebo effect in postoperative pain].
Topics: Female; Humans; Male; Methadone; Pain; Placebos; Postoperative Complications; Pyrazoles; Sulfonic Ac | 1969 |