methadone has been researched along with Abnormalities, Drug-Induced in 26 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study compared the acoustic cry characteristics of infants born to mothers maintained on methadone during pregnancy with those of infants not exposed to methadone during pregnancy." | 7.75 | Acoustic cry characteristics of infants exposed to methadone during pregnancy. ( Quick, ZL; Robb, MP; Woodward, LJ, 2009) |
| "Moderately strong evidence indicates lower risk of preterm birth, greater birth weight and larger head circumference with buprenorphine treatment of maternal opioid use disorder during pregnancy compared with methadone treatment, and no greater harms." | 4.93 | Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child. ( Amick, HR; Jones, HE; Joyce, AR; Kim, MM; Mann, AL; Murrelle, EL; Zedler, BK, 2016) |
| " This study compared the acoustic cry characteristics of infants born to mothers maintained on methadone during pregnancy with those of infants not exposed to methadone during pregnancy." | 3.75 | Acoustic cry characteristics of infants exposed to methadone during pregnancy. ( Quick, ZL; Robb, MP; Woodward, LJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (69.23) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lind, JN | 1 |
| Interrante, JD | 1 |
| Ailes, EC | 1 |
| Gilboa, SM | 1 |
| Khan, S | 1 |
| Frey, MT | 1 |
| Dawson, AL | 1 |
| Honein, MA | 1 |
| Dowling, NF | 1 |
| Razzaghi, H | 1 |
| Creanga, AA | 1 |
| Broussard, CS | 1 |
| Zedler, BK | 1 |
| Mann, AL | 1 |
| Kim, MM | 1 |
| Amick, HR | 1 |
| Joyce, AR | 1 |
| Murrelle, EL | 1 |
| Jones, HE | 1 |
| Quick, ZL | 1 |
| Robb, MP | 1 |
| Woodward, LJ | 1 |
| Rosen, TS | 2 |
| Johnson, HL | 1 |
| Harris, VJ | 1 |
| Srinivasan, G | 1 |
| Wapner, RJ | 1 |
| Fitzsimmons, J | 1 |
| Ross, RD | 1 |
| Rudrauff, ME | 1 |
| Kurtz, AB | 1 |
| Finnegan, LP | 1 |
| Olofsson, M | 1 |
| Buckley, W | 1 |
| Andersen, GE | 1 |
| Friis-Hansen, B | 1 |
| Joffe, JM | 1 |
| Soyka, LF | 1 |
| Aylward, GP | 1 |
| Chasnoff, IJ | 1 |
| Hatcher, R | 1 |
| Burns, WJ | 1 |
| Erhart, NA | 1 |
| Sinatra, FR | 1 |
| Anyaegbunam, A | 1 |
| Tran, T | 1 |
| Jadali, D | 1 |
| Randolph, G | 1 |
| Mikhail, MS | 1 |
| Cayol, V | 1 |
| Corcos, M | 1 |
| Clervoy, P | 1 |
| Speranza, M | 1 |
| Geber, WF | 1 |
| Schramm, LC | 1 |
| Ghodse, AH | 1 |
| Reed, JL | 1 |
| Mack, JW | 1 |
| Jones, KL | 1 |
| Chernoff, GF | 1 |
| Vargas, GC | 1 |
| Pildes, RS | 1 |
| Vidyasagar, D | 1 |
| Keith, LG | 1 |
| Chandler, JM | 1 |
| Robie, PW | 1 |
| Schoolar, JC | 1 |
| Desmond, MM | 1 |
| Hutchings, DE | 1 |
| Hunt, HF | 1 |
| Towey, JP | 1 |
| Gorinson, HS | 1 |
| Rommelspacher, H | 1 |
| Kattner, E | 1 |
| Vernadakis, A | 1 |
| Gibson, A | 1 |
| Jurand, A | 2 |
| Rothstein, P | 1 |
| Gould, JB | 1 |
| Markham, JK | 1 |
| Emmerson, JL | 1 |
| Owen, NV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Buprenorphine vs Buprenorphine/Naloxone on the Effects of Maternal Symptomatology[NCT03740243] | Phase 4 | 0 participants (Actual) | Interventional | 2018-11-30 | Withdrawn (stopped due to No enrollment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for methadone and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Maternal Use of Opioids During Pregnancy and Congenital Malformations: A Systematic Review.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Female; Humans; Methadone; Morphine Derivatives; Op | 2017 |
Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: a systematic review and meta-analysis of safety in the mother, fetus and child.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Birth Weight; Buprenorphine; Female; Fetal Death; F | 2016 |
Infants of drug-dependent mothers.
Topics: Abnormalities, Drug-Induced; Female; Fetal Alcohol Spectrum Disorders; Fetal Growth Retardation; Her | 1983 |
Paternal drug exposure: effects on reproduction and progeny.
Topics: Abnormalities, Drug-Induced; Animals; Endocrine Glands; Ethanol; Fathers; Gonadal Steroid Hormones; | 1982 |
[Pregnancy and drug abuse: current situation and therapeutic strategies].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Female; Fetal Growth Retardation; Hepatit | 2000 |
The effect of maternal narcotic addiction on the newborn infant.
Topics: Abnormalities, Drug-Induced; Breast Feeding; Female; Fertility; Heroin Dependence; Humans; Infant Mo | 1977 |
Drugs and chemicals associated with intrauterine growth deficiency.
Topics: Abnormalities, Drug-Induced; Adult; Aminopterin; Animals; Disease Models, Animal; Ethanol; Female; F | 1978 |
[The pharmacology of drugs (heroin, L-methadone, cocaine, hashish) and their effects on pregnancy, fetus and neonate].
Topics: Abnormalities, Drug-Induced; Amphetamine; Cannabinoids; Cocaine; Female; Fetus; Heroin; Humans; Infa | 1991 |
[Findings in newborn infants following drug abuse or drug weaning in the mother].
Topics: Abnormalities, Drug-Induced; Adult; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Inf | 1991 |
17 other studies available for methadone and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Acoustic cry characteristics of infants exposed to methadone during pregnancy.
Topics: Abnormalities, Drug-Induced; Acoustics; Analgesics, Opioid; Crying; Female; Humans; Infant Welfare; | 2009 |
Children of methadone-maintained mothers: follow-up to 18 months of age.
Topics: Abnormalities, Drug-Induced; Developmental Disabilities; Female; Follow-Up Studies; Humans; Infant; | 1982 |
A quantitative evaluation of fetal growth failure in a drug-abusing population.
Topics: Abnormalities, Drug-Induced; Female; Fetal Growth Retardation; Gestational Age; Humans; Methadone; P | 1981 |
[Condition of 89 newborn infants of drug-addicted mothers].
Topics: Abnormalities, Drug-Induced; Adult; Apgar Score; Female; Heroin Dependence; Humans; Infant, Low Birt | 1983 |
Methadone outcome studies: is it more than the methadone?
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Met | 1982 |
Polydrug- and methadone-addicted newborns: a continuum of impairment?
Topics: Abnormalities, Drug-Induced; Birth Weight; Child Behavior; Female; Heroin Dependence; Humans; Infant | 1982 |
Biliary atresia, intestinal malrotation, partial abdominal heterotaxia, and craniofacial anomalies in a newborn with intrauterine opiate exposure.
Topics: Abdomen; Abnormalities, Drug-Induced; Biliary Atresia; Cleft Lip; Cleft Palate; Female; Heroin; Huma | 1994 |
Assessment of fetal well-being in methadone-maintained pregnancies: abnormal nonstress tests.
Topics: Abnormalities, Drug-Induced; Adult; Analgesics, Opioid; Case-Control Studies; Exercise Test; Female; | 1997 |
Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster.
Topics: Abnormalities, Drug-Induced; Analgesics, Opioid; Animals; Central Nervous System; Female; Fetal Deat | 1975 |
Effect of maternal heroin addiction on 67 liveborn neonates. Withdrawal symptoms, small body size, and small head circumference were frequent findings.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Birth Weight; Blood Glucose; Cephalomet | 1975 |
The effects of methadone on maternal-fetal interactions in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Dose-Response Relationship, Drug; Female; Fetal D | 1975 |
Methadone during pregnancy in the rat: dose level effects on maternal and perinatal mortality and growth in the offspring.
Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Body Weight; Female; Fetal Death; Fetus; Gestati | 1976 |
Neurotoxicity of opiates during brain development: in vivo and in vitro studies.
Topics: Abnormalities, Drug-Induced; Animals; Binding Sites; Brain; Cells, Cultured; Chick Embryo; Etorphine | 1985 |
The interference of naloxone hydrochloride in the teratogenic activity of opiates.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Central Nervous System; D-Ala(2),MePh | 1985 |
Teratogenic activity of methadone hydrochloride in mouse and chick embryos.
Topics: Abnormalities, Drug-Induced; Anencephaly; Animals; Brain; Chick Embryo; Embryo, Mammalian; Female; G | 1973 |
Born with a habit. Infants of drug-addicted mothers.
Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Barbiturates; Camphor; Chlorpromazine; Codeine; Dia | 1974 |
Teratogenicity studies of methadone HCl in rats and rabbits.
Topics: Abnormalities, Drug-Induced; Animals; Female; Hydrocephalus; Maternal-Fetal Exchange; Methadone; Pre | 1971 |