methadone has been researched along with Abnormalities, Autosome in 10 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The methadone treatment was found to increase the rate of preimplantation deaths consistently in all post-meiotic stages with all doses used." | 1.26 | On the mutagenicity of methadone hydrochloride. Induced dominant lethal mutation and spermatocyte chromosomal aberrations in treated males. ( Badr, FM; Badr, RS; Rabouh, SA, 1979) |
| " In the mothers, no significant differences were found with respect to dosage and duration of methadone treatment and years of heroin abuse." | 1.26 | Cytogenetics of methadone-managed and heroin-addicted pregnant women and their newborn infants. ( Amarose, AP; Norusis, MJ, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Falek, A | 4 |
| Hollingsworth, F | 2 |
| Zimmering, S | 1 |
| Badr, FM | 1 |
| Rabouh, SA | 1 |
| Badr, RS | 1 |
| Amarose, AP | 2 |
| Matsuyama, SS | 1 |
| Charuvastra, VC | 1 |
| Jarvik, LF | 1 |
| Fu, TK | 1 |
| Sanders, K | 1 |
| Yen, FS | 1 |
| Abrams, CA | 1 |
| Norusis, MJ | 1 |
| McFadden, IJ | 1 |
| Jordan, RB | 1 |
| King, BJ | 1 |
| Arnold, PJ | 1 |
| Skelton, WD | 1 |
1 trial available for methadone and Abnormalities, Autosome
| Article | Year |
|---|---|
Chromosomes in patients receiving methadone and methadyl acetate.
Topics: Adult; Chromosome Aberrations; Double-Blind Method; Heroin Dependence; Humans; Leukocytes; Male; Met | 1978 |
9 other studies available for methadone and Abnormalities, Autosome
| Article | Year |
|---|---|
Opiates and human chromosome alterations.
Topics: Adult; Chromosome Aberrations; Cytological Techniques; Female; Heroin; Humans; Leukocytes; Male; Met | 1980 |
Heroin and chromosome damage.
Topics: Adult; Chromosome Aberrations; Female; Heroin; Heroin Dependence; Humans; Male; Methadone; Methadyl | 1980 |
Evidence for the absence of a mutagenic effect of methadone in germ cells of Drosophila melanogaster.
Topics: Animals; Chromosome Aberrations; Drosophila melanogaster; Drug Evaluation, Preclinical; Female; Gene | 1979 |
On the mutagenicity of methadone hydrochloride. Induced dominant lethal mutation and spermatocyte chromosomal aberrations in treated males.
Topics: Animals; Chromosome Aberrations; Dose-Response Relationship, Drug; Female; Fertility; Genes, Dominan | 1979 |
Chromosome aberrations in the mother and the newborn from drug-addiction pregnancies.
Topics: Blood Cells; Chromatids; Chromosome Aberrations; Female; Heroin Dependence; Humans; Infant, Newborn; | 1978 |
Cytogenetic risks to the offspring of pregnant addicts.
Topics: Chromosome Aberrations; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Karyotyping; Male | 1975 |
Cytogenetics of methadone-managed and heroin-addicted pregnant women and their newborn infants.
Topics: Adolescent; Adult; Apgar Score; Chromosome Aberrations; Female; Fetal Blood; Heroin Dependence; Huma | 1976 |
Cytogenetic follow-up of patients in a methadone maintenance program.
Topics: Adult; Chromosome Aberrations; Cytogenetics; Follow-Up Studies; Georgia; Heroin Dependence; Humans; | 1973 |
Human chromosomes and opiates.
Topics: Adult; Cells, Cultured; Chromosome Aberrations; Chromosomes; Dose-Response Relationship, Drug; Femal | 1972 |