methadone has been researched along with AIDS Dementia Complex in 4 studies
Methadone: A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
methadone : A racemate comprising equimolar amounts of dextromethadone and levomethadone. It is a opioid analgesic which is used as a painkiller and as a substitute for heroin in the treatment of heroin addiction.
6-(dimethylamino)-4,4-diphenylheptan-3-one : A ketone that is heptan-3-one substituted by a dimethylamino group at position 6 and two phenyl groups at position 4.
AIDS Dementia Complex: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intravenous drug abuse is a major risk factor for HIV-1 infection, and opioids have been shown to alter the progression and severity of HAND." | 2.53 | Opioids and Opioid Maintenance Therapies: Their Impact on Monocyte-Mediated HIV Neuropathogenesis. ( Berman, JW; Carvallo, L; Jaureguiberry-Bravo, M; Wilson, R, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jaureguiberry-Bravo, M | 1 |
| Wilson, R | 1 |
| Carvallo, L | 1 |
| Berman, JW | 1 |
| Silberstein, CH | 1 |
| O'Dowd, MA | 1 |
| Chartock, P | 1 |
| Schoenbaum, EE | 1 |
| Friedland, G | 1 |
| Hartel, D | 1 |
| McKegney, FP | 1 |
| Handelsman, L | 2 |
| Song, IS | 1 |
| Losonczy, M | 1 |
| Park, S | 1 |
| Jacobson, J | 2 |
| Wiener, J | 2 |
| Aronson, M | 2 |
| Horvath, T | 1 |
| Schroeder, M | 1 |
| Peterson, A | 1 |
| Holloway, K | 1 |
| Ness, R | 1 |
| Herman, S | 1 |
1 review available for methadone and AIDS Dementia Complex
| Article | Year |
|---|---|
Opioids and Opioid Maintenance Therapies: Their Impact on Monocyte-Mediated HIV Neuropathogenesis.
Topics: AIDS Dementia Complex; Analgesics, Opioid; Blood-Brain Barrier; Buprenorphine; Cell Movement; HIV In | 2016 |
3 other studies available for methadone and AIDS Dementia Complex
| Article | Year |
|---|---|
A prospective four-year follow-up of neuropsychological function in HIV seropositive and seronegative methadone-maintained patients.
Topics: Adult; AIDS Dementia Complex; Ambulatory Care; Female; Follow-Up Studies; HIV Seronegativity; HIV Se | 1993 |
Magnetic resonance abnormalities in HIV infection: a study in the drug-user risk group.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; Brain; Brain Diseases; Cognition D | 1993 |
Auditory event-related potentials in HIV-1 infection: a study in the drug-user risk group.
Topics: Adult; AIDS Dementia Complex; Brain Stem; Evoked Potentials, Auditory, Brain Stem; HIV Seropositivit | 1992 |